Edad avanzada y Rejuvenecimiento

Las consecuencias del envejecimiento reproductivo se observan a diario en las clínicas de reproducción. Por esto, los investigadores de IVIRMA Global están trabajando para identificar los mecanismos que producen dicho envejecimiento.

Entre los proyectos, destacan:

cambios en el epigenoma relacionado con la edad
dinámicas de telómeros en gametos y sangre periférica
función mitocondrial en la preimplantación de embriones

El equipo científico también ha centrado sus investigaciones en identificar nuevas estrategias de tratamiento que puedan activar los folículos primordiales en pacientes que presenten un estado avanzado de envejecimiento reproductivo. Gracias a estas técnicas, se han conseguido embarazos en varios pacientes a los que previamente se les había diagnosticado un fallo ovárico prematuro

Investigadores trabajando en este área

Antonio Pellicer , M.D., Ph.D.

Founding Partner IVIRMA Global

Emre Seli, M.D.

Research Director at IVIRMA Global

Juan García Velasco, M.D., Ph.D.

Director of IVI Madrid

Sonia Herraiz, Ph.D.

Ovarian Rejuvenation and Fertility Preservation Research Group Leader at FIVI.

Irene Cervelló, Ph.D.

Laboratory Manager & Endometrial Stem Cell and Bioengineering Research Group Leader at the IVI Foundation Research Department

Elisa Varela, Ph.D

Principal Investigator of the Telomeres in Reproduction at FIVI-IVIRMA

Carmina Vidal, M.D., Ph.D.

Gynecologist and Reproductive Medicine Specialist at IVI Valencia

Evelin Lara, M.D.

Director of the Egg Donation Unit at IVI Barcelona

Roberto Matorras, M.D., Ph.D.

Coordinator for Research and Education at IVI Bilbao

Scott Morin, M.D.

Reproductive Endocrinologist at RMA of Northern California

RMA Northen California

José Remohí, Ph.D

Founding Partner IVI-RMA Global

Human Fatemi, M.D., Ph.D.

Medical Director of the IVI Middle East

IVI Middle East

Richard T Scott, M.D.,H.C.L.D.

Chief Executive Officer for IVIRMA Global

Reproductive Medicine Specialist

Pilar Alamá, M.D., Ph.D.

Director of the Egg Donation Unit

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Públicaciones en este área

Diminished Ovarian Reserve Chemotherapy-Induced Mouse Model: A Tool for the Preclinical Assessment of New Therapies for Ovarian Damage.
Buigues A Marchante M Herraiz S Pellicer A
Reprod Sci. 2019 Feb 21:1933719119831784. doi: 10.1177/1933719119831784. [Epub ahead of print]
Diminished ovarian reserve versus ovarian aging: overlaps and differences.
Ata B Seyhan A Seli E
Curr Opin Obstet Gynecol. 2019 Feb 18. doi: 10.1097/GCO.0000000000000536. [Epub ahead of print]
Mitochondria as a tool for oocyte rejuvenation.
Labarta E de Los Santos MJ Escribá MJ Pellicer A Herraiz S
Fertil Steril. 2019 Jan 2. pii: S0015-0282(18)32162-9. doi: 10.1016/j.fertnstert.2018.10.036. [Epub ahead of print] Review.
Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance.
Morin SJ Patounakis G Juneau CR Neal SA Scott RT Seli E
Hum Reprod, 33(8):1489-1498, 2018.
Mathematical model to study the aging of the human follicle according to the telomerase activity.
Portillo AM Varela E García-Velasco JA
J Theor Biol, 462:446-454, 2018.
DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation.
Morin SJ Tao X Marin D Zhan Y Landis J Bedard J Scott RT Seli E
Aging (Albany NY), 10(12):3761-3773, 2018.
Autologous stem cell ovarian transplantation to increase reproductive potential in patients who are poor responders.
Herraiz S Romeu M Buigues A Martínez J Díaz-García C Gómez-Seguí I Pellicer N Pellicer A
Fertil Steril, 110(3):496-505, 2018.
Fertility, IVF and reproductive genetics.
Varela E Sánchez-de-Puerta I García-Velasco JA
Curr Opin Obstet Gynecol, 30(3):203-208, 2018.
Should we consider telomere length and telomerase activity in male factor infertility?
Balmori C Varela E
Curr Opin Obstet Gynecol, 30(3):197-202, 2018.
The dilemma of aneuploidy screening on low responders.
Morin SJ Kaser DJ Franasiak JM
Curr Opin Obstet Gynecol, 30(3):179-184, 2018.

Selection of preimplantation embryos using time-lapse microscopy in in vitro fertilization: State of the technology and future directions.
Aparicio-Ruiz B Romany L Meseguer M
Birth Defects Res, 110(8):648-653, 2018.
Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos.
Wang T Babayev E, Jiang Z Li G Zhang M Esencan E Horvath T Seli E
Aging Cell, 30:e12784. doi: 10.1111/acel.12784, 2018.
Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion.
Herraiz S Buigues A Díaz-García C Romeu M Martínez S Gómez-Seguí I Simón C Hsueh AJ Pellicer A
Fertil Steril, 109(5):908-918, 2018.
Human Endometrial Reconstitution From Somatic Stem Cells: The Importance of Niche-Like Cells.
Lopez-Perez N Gil-Sanchis C Ferrero H Faus A Diaz A Pellicer A Cervelló I Simón C
Reprod Sci, NA:NA-NA, 2018.
Impact of vitamin D levels on ovarian reserve and ovarian response to ovarian stimulation in oocyte donors.
Fabris AM Cruz M Iglesias C Pacheco A Patel A Patel J Fatemi HM García-Velasco JA
Reprod Biomed Online. 2017 May 19. pii: S1472-6483(17)30235-3. doi: 10.1016/j.rbmo.2017.05.009.
DHEA supplementation can result in assay changes which may impact decision in IVF
Franasiak JM Forman E Scott RT
J Assist Reprod Genet, 34:959, 2017.
Telomeres in aging and reproduction.
Varela E Sánchez de Puerta I García-Velasco JA
Current Opinion in Obstetrics and Gynecology (in preparation).
Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality.
Cariati F Jaroudi S Alfarawati S Raberi A Alviggi C Pivonello R Wells D
Reprod Biomed Online, 33:404–411, 2016.
Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations
Varela E Muñoz M Tejera M Ortega I Blasco M
Nature Communications, 7: 11739-11755.2016.
Aging is associated with changes in mitochondrial dynamics, function and mtDNA quantity.
Babayev E Wang T Szigeti-Buck K Lowther K Taylor HS Horvath T Seli E
Maturitas, 93:121-130, 2016.
Mitochondrial DNA as a biomarker for in vitro fertilization (IVF) outcome
Seli E
Curr Opin Obstet Gynecol, 28:158-63, 2016.
Using donor gametes, embryos.
Iglesias C Ortega I García-Velasco JA
Excessive Age-Related Decline in Functional Ovarian Reserve in Infertile Women: Prospective Cohort of 15,500 Women.
Iliodromiti S Iglesias C Messow CM Cruz M García-Velasco JA Nelson SM
J Clin Endocrinol Metab, 101(9):3548-54, 2016.
Effect of surgery on ovarian reserve in women with endometriomas, endometriosis and controls.
Goodman L Goldberg J Flyckt RL Gupta M Harwalkar J Falcone T
Am J Obstet Gynecol. 2016 Nov;215(5):589.e1-589.e6.
A new more detailed stratification of low responders to ovarian stimulation: from a poor ovarian response to a low prognosis concept.
Alviggi C Andersen CY Buehler K Conforti A De Placido G
Fertil Steril; 105 (6): 1452-1453, 2016.
Exccesive age-related decline in functional ovarian reserve in infertile women: prospective cohort of 15500 women.
Iliodromiti S Iglesias C Messow CM Cruz M García-Velasco JA Nelson SM
J Clin Endocrinol Metab, 10:3548-3554, 2016
Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential.
Fragouli E Spath K Alfarawati S Kaper F Craig A Michel CE Kokocinski F Cohen J Munné S Wells D
PLOS Genet, 11, 2015.
Oocyte mitochondrial function and reproduction.
Babayev E Seli E
Curr Opin Obstet Gynecol, 27:175-81, 2015.
Strategies for controlled ovarian stimulation in the setting of ovarian ageing.
Ata B Seli E
Semin Reprod Med, 33:436-48, 2015.
Oocyte cryopreservation as a preventive measure for age-related fertility loss.
Cil AP Turkgeldi L Seli E
Semin Reprod Med, 33:429-35, 2015.
Ovarian ageing
Seli E
Semin Reprod Med, 33:375-6, 2015.
Role of oocyte vitrification for fertility preservation programs.
Herrero J Rubio I
Curr Trends Clin Embryol, 2 (5): 167-176, 2015.
Contribution of different bone marrow-derived cell types in endometrial regeneration using an irradiated murine model.
Gil-Sanchis C Cervelló I Khurana S Faus A Verfaillie C Simón C
Fertil Steril, 103(6):1596-605, 2015
Genetic associations with diminished ovarian reserve: a systematic review of the literature.
Greene AD Patounakis G Segars JH
J Assist Reprod Genet, 31:935-46. 2014.
Aneuploidy across individual chromosomes at the embryonic level in trophectoderm biopsies: changes with patient age and chromosome structure.
Franasiak JM Forman EJ Hong KH Werner MD Upham KM Treff NR
Assist Reprod Genet 2014.
The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening.
Franasiak JM Forman EJ Hong KH Werner MD Upham KM Treff NR
Fertil Steril 2014;101(3):656–663.e1.
Diminished Effect of Maternal Age on Implantation After Preimplantation Genetic Diagnosis With Array Comparative Genomic Hybridization.
Harton GL Munné S Surrey M Grifo J Kaplan B McCulloh DH Griffin DK Wells D PGD Practitioners Group.
Obstet Gynecol Surv, 69:744–745, 2014.
Ehtnicity as a determinant of the ovarian reserve: differences in ovarian aging between Spanish and Indian women.
Iglesias C Banker M Mahajan N Herrero L García-Velasco JA
Fertil Steril 102(1):244-9, 2014
Response: poor responders and androgen adjuvant treatment: "still haven't found what I'm looking for…".
García-Velasco JA
Reprod Biomed Online. 29:653-4, 2014.
Poor responders and androgen adjuvant treatment: "Still haven't found what I'm looking for...".
García-Velasco JA
Reprod Biomed Online.28:661-2, 2014.
The Nature of Aneuploidy with Increasing Age of the Female Partner: A Review of 15,169 Trophectoderm Biopsies Undergoing Comprehensive Chromosomal Screening.
Franasiak JM Forman EJ Hong KH Werner MD Upham K Treff NR Scott RT
Fertil Steril, 101:656-663, 2014.
Is vitrification of oocytes useful for fertility preservation for age-related fertility decline and in cancer patients?
Cobo A García-Velasco JA Domingo J Pellicer A
Fertil Steril, 99:1485-1495, 2013
Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials.
Rubio C Bellver J Rodrigo L Bosch E Mercader A Vidal C De Los Santos MJ Giles J
Fertil Steril, 99(5):1400-7, 2013
Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes.
Munné S Held KR Magli CM Ata B Wells D Fragouli E Baukloh V Fischer R Gianaroli L
Fertil Steril, 97:935–942, 2012.
Different telomere-length dynamics at the Inner Cell Mass versus Established Embryonic Stem (ES) cells.
Varela E Schneider RP Ortega S Blasco MA
Proc Nat Acad USA, 108:15207-15212. 2011.
Fertility after age 45: From natural conception to assisted reproductive technology and beyond.
Forman EJ Treff NR Scott RT
Maturitas, 70:216-221, 2011.
2009 Nobel prize in phisyiology or medicine: telomeres and telomerase.
Varela E Blasco MA
Oncogene, 11: 1561-1565.2010.
Swim-up procedure selects spermatozoa with longer telomere length.
Santiso R Tamayo M Gosálvez J Meseguer M Garrido N Fernández JL
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 688:88-90, 2010.
Third party reproduction and the aging couple.
Luk J Greenfeld D
Maturitas, 66:389-96, 2010.
Redefining advanced maternal age as an indication for implantation genetic screening.
Milán M Cobo A Rodrigo L Mateu E Mercader A Buendía P Peinado V Delagado A MIr P Simón C Remohí J
Reprod Biomed Online, 21(5); 649-57, 2010.
Influence of paternal age on assisted reproduction outcome.
Bellver J Garrido N Remohí J Pellicer A Meseguer M
Reprod Biomed Online, 17:595-604, 2008.
Male age negatively impacts embryo development and reproductive outcome in donor oocyte ART cycles.
Scott RT Elkind-Hirsch KE Miller BT Miller KA Frattarelli JL
Fertil Steril, 90: 97- 103, 2008.
Maternal age-related differential global expression profiles observed in human oocytes.
Steuerwald NM Bermúdez MG Wells D Munné S Cohen J
Reprod Biomed Online, 14:700–708, 2007.
Age and uterine receptiveness: predicting the outcome of oocyte donation cycles.
Soares SR Troncoso C Bosch E Serra V Simón C Remohí J Pellicer A
J Clin Endocrinol Metab, 90(7):4399-404, 2005.
Diminished ovarian reserve and access to care.
Scott RT
Fertil Steril, 81:1489-92;discussion 496-7, 2004.
Infertility after age 35: Diagnostic strategies.
Seifer DB Scott RT Buyalos RP
Ob Gyn Management, 55-61. 1996.
Age related decline in Female fertility is not due to diminished capacity of the uterus to sustain embryo implantation.
Navot D Drews MR Bergh PA Guzman I Karstaedt A Scott RT Garrisi GJ Hofmann GE
Fertil Steril, 61:97-101, 1994.
Incidence of endometrial hyperplasia in postmenopausal women taking conjugated estrogens (Premarin) with medroxyprogesterone acetate or conjugated estrogens alone.
Woodruff JD Pickar JH Menopause Study Group
Am J Obstet Gynecol, 170:1213-23, 1994.
Bleeding patterns in postmenopausal women taking continuous combined or sequential regimens of conjugated estrogens with medroxyprogesterone acetate
Archer DF Pickar JH Bottiglioni F Menopause Study Group
Obstet Gynecol, 83:686-92, 1994.
Pituitary luteinizing hormone (LH) secretion: Effect of different concentrations of serum 17ß-estradiol in postmenopausal women.
Karande VC Scott RT Archer DF
Ann NYAS, 592:405-8, 1990.
The relationship between serum estradiol-17ß concentrations and induced pituitary luteinizing hormone (LH) surges in post- menopausal women.
Karande VC Scott RT Archer DF
Fertil Steril, 54:217, 1990

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