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The Distribution of High and Low-Level Mosaicism and Maternal Age: Lessons and Hesitations

Stephanie Willson, Thomas Molinaro

F&S Reports Available online 15 June 2023 In press. 2023 doi:

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Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis. Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, Poli M, Hynes J, Gemmell L, Vaiarelli A, Alviggi C, Ubaldi FM, Capalbo A Hum Reprod Update. 2023 May 16:dmad010. doi: 10.1093/humupd/dmad010. Online ahead of print.. 2023 doi:	2023
Antimüllerian hormone (AMH) and age as predictors of preimplantation genetic testing for aneuploidies (PGT-A) cycle outcomes and blastocyst quality on day 5 in women undergoing in vitro fertilization (IVF). Arnanz A, Bayram A, Elkhatib I, Abdala A, El-Damen A, Patel R, Lawrenz B, Melado L, Fatemi H, De Munck N J Assist Reprod Genet. 2023 May 5. doi: 10.1007/s10815-023-02805-z. Online ahead of print.. 2023 doi:	2023
BOLOGNA VS POSEIDON CRITERIA AS PREDICTORS OF THE LIKELIHOOD OF OBTAINING AT LEAST ONE EUPLOID EMBRYO IN POOR OVARIAN RESPONSE: AN ANALYSIS OF 6,889 CYCLES Reig A, Garcia-Velasco JA, Seli E Fertility and SterilityAvailable online 13 May 2023 In press. 2023 doi:	2023
Deep learning system for classification of ploidy status using time-lapse videos. Paya E, Pulgarín C, Bori L, Colomer A, Naranjo V, Meseguer M F S Sci. 2023 Jun 30:S2666-335X(23)00035-6. doi: 10.1016/j.xfss.2023.06.002. Online ahead of print.. 2023 doi:	2023
Discard or not discard, that is the question: an international survey across 117 embryologists on the clinical management of borderline quality blastocysts. Chiappetta V, Innocenti F, Coticchio G, Ahlström A, Albricci L, Badajoz V, Hebles M, Gallardo M, Benini F, Canosa S, Kumpošt J, Milton K, Montanino Oliva D, Maggiulli R, Rienzi L, Cimadomo D Hum Reprod. 2023 Aug 30:dead174. doi: 10.1093/humrep/dead174. Online ahead of print.. 2023 doi:	2023
ESHRE PGT Consortium data collection XXI: PGT analyses in 2018. Spinella F, Bronet F, Carvalho F, Coonen E, De Rycke M, Rubio C, Goossens V, Van Montfoort A Hum Reprod Open. 2023 Apr 19;2023(2):hoad010. doi: 10.1093/hropen/hoad010. eCollection 2023.. 2023 doi:	2023
Healthy live birth following embryo transfer of a blastocyst of tetrapronuclear (4PN) origin: a case report. Bredbacka P, Capalbo A, Kananen K, Picchetta L, Tomás C Hum Reprod. 2023 Aug 1:dead151. doi: 10.1093/humrep/dead151. Online ahead of print.. 2023 doi:	2023
Investigating the significance of segmental aneuploidy findings in preimplantation embryos Ludovica Picchetta, Christian S Ottolini, Helen C O'Neill, Antonio Capalbo F S Sci. 2023 Mar 20:S2666-335X(23)00015-0. doi: 10.1016/j.xfss.2023.03.004. Online ahead of print.. 2023 doi:	2023
Mosaic results after preimplantation genetic testing for aneuploidy may be accompanied by changes in global gene expression. Martin A, Mercader A, Dominguez F, Quiñonero A, Perez M, Gonzalez-Martin R, Delgado A, Mifsud A, Pellicer A, De Los Santos MJ Front Mol Biosci. 2023 Apr 14;10:1180689. doi: 10.3389/fmolb.2023.1180689. eCollection 2023.. 2023 doi:	2023
PGT-HLA programmes for the cure of a sick sibling: clinical strategies for this challenging search Cinzia Caligara, Esther Santamaría-López, María José Hernáez, Ana Ortiz-Vallecillo, Myriam Ruíz, Nicolás Prados, Cristina Gonzalez-Ravina, Manuel Fernández-Sánchez Reproductive BioMedicine OnlineAvailable online 12 September 2023 In press. 2023 doi:	2023
Preimplantation genetic testing for aneuploidy is not related to adverse obstetric and neonatal outcomes in singleton pregnancies. Cozzolino M, Nardini Cecchino G, Garcia Velasco JA, Pellicer N, Galliano D, Pellicer A Hum Reprod. 2023 Jun 19:dead123. doi: 10.1093/humrep/dead123. Online ahead of print.. 2023 doi:	2023
Reply of the Authors: Recurrent implantation failure: reality or a statistical mirage? Paul Pirtea MD a, Marcelle I Cedars MD b, Kate Devine MD c, Baris Ata MD, PhD d e, Jason Franasiak MD f, Catherine Racowsky PhD a, Jim Toner MD, PhD g, Richard T Scott MD f, Dominique de Ziegler MD a, Kurt T Barnhart Fertility and SterilityAvailable online 14 April 2023 In press. 2023 doi:	2023
Should embryo rebiopsy be considered a regular strategy to increase the number of embryos available for transfer? Nohales M, Coello A, Martin A, Insua F, Meseguer M, de Los Santos MJ J Assist Reprod Genet. 2023 Jul 11. doi: 10.1007/s10815-023-02875-z. Online ahead of print.. 2023 doi:	2023
The first mitotic division: a perilous bridge connecting the zygote and the early embryo Giovanni Coticchio, Danilo Cimadomo, Greta Chiara Cermisoni, Laura Rienzi, Enrico Papaleo, Filippo Maria Ubaldi, Andrea Borini, Lucia De Santis Human Reproduction, Volume 38, Issue 6, June 2023, Pages 1019–1027, https://doi.org/10.1093/humrep/dead067. 2023 doi:	2023
The Ratio of Serum Progesterone (P4) to the Number of Follicles (P4/follicle) is a More Objective Parameter for Euploidy Rate as Compared to Systemic Progesterone Levels. Ali KIA, Lawrenz B, Shanker U, Ruiz F, El-Damen A, ElKhatib I, Fatemi H, De Munck N Reprod Sci. 2023 May 16. doi: 10.1007/s43032-023-01258-0. Online ahead of print.. 2023 doi:	2023
A randomized, non-inferiority trial on the DuoStim strategy in PGT-A cycles María Cerrillo, Gustavo N Cecchino, MónicaToribio, María JGarcía-Rubio, Juan AGarcía-Velasco Reproductive BioMedicine Online Available online 25 November 2022 In press. 2022 doi:	2022
Correction: Embryos of Robertsonian Translocation Carriers Exhibit a Mitotic Interchromosomal Effect That Enhances Genetic Instability during Early Development. Alfarawati S, Fragouli E, Colls P, Wells D PLoS Genet. 2022 Aug 29;18(8):e1010377. doi: 10.1371/journal.pgen.1010377. eCollection 2022 Aug.. 2022 doi:	2022
Impact of parental chromosomal polymorphisms on the incidence of congenital anomalies and perinatal complications in a cohort of newborns conceived after ICSI + PGT-A. Rodriguez F, Cruz M, Requena A Reprod Biol Endocrinol.. 2022 Sep. doi: 10.1186/s12958-022-01012-2.	2022
Limits imposed by the experimental design of a large prospective non-inferiority study on PGT-A invalidate many of the conclusions. Scott RT, de Ziegler D, Pirtea P, Jalas C Hum Reprod. 2022 Oct 26:deac224. doi: 10.1093/humrep/deac224. Online ahead of print.. 2022 doi:	2022
Mosaic Embryo Transfer: A cautionary tale Jason M Franasiak F&S Reports. 2022 doi:	2022
On the reproductive capabilities of aneuploid human preimplantation embryos. Capalbo A, Poli M, Jalas C, Forman EJ, Treff NR Am J Hum Genet. 2022 Sep 1;109(9):1572-1581. doi: 10.1016/j.ajhg.2022.07.009.. 2022 doi:	2022
Predicting embryonic aneuploidy rate in IVF patients using whole-exome sequencing. Sun S, Miller M, Wang Y, Tyc KM, Cao X, Scott RT Jr, Tao X, Bromberg Y, Schindler K, Xing J Hum Genet. 2022 doi: 10.1007/s00439-022-02450-z	2022
Switching to testicular sperm after a previous ICSI failure with ejaculated sperm significantly improves blastocyst quality without increasing aneuploidy risk. Hervas I, Gil Julia M, Rivera-Egea R, Navarro-Gomezlechon A, Mossetti L, Garrido N J Assist Reprod Genet.. 2022 Aug. doi: 10.1007/s10815-022-02595-w. Online ahead of print.	2022
The chances of obtaining a euploid embryo and subsequent live birth remain consistent with national age-based rates after an in vitro fertilization cycle that produced only aneuploid embryos. Herlihy NS, Klimczak AM, Cheung JKW, Seli E, Scott RT Jr Fertil Steril. 2022 Jun 9:S0015-0282(22)00335-1. Online ahead of print. 2022 doi: 10.1016/j.fertnstert.2022.05.026	2022
Update on preimplantation genetic testing for aneuploidy and outcomes of embryos with mosaic results. Dahdouh EM, Mourad AM, Balayla J, Sylvestre C, Brezina PR, Kutteh WH, Picchetta L, Capalbo A, Garcia-Velasco JA Minerva Obstet Gynecol. 2022 Oct 18. doi: 10.23736/S2724-606X.22.05166-1. Online ahead of print.. 2022 doi:	2022
We know to err (meiotically) is human, but do paternal factors impact paternal aneuploidy? Andres Reig, Jason M Franasiak Fertility and Sterility. Available online 30 June 2022 In Press, Corrected Proof. 2022 doi:	2022
Clinical application of sequencing-based methods for parallel preimplantation genetic testing for mitochondrial DNA disease and aneuploidy Spath, K, Babariya, D, Konstantinidis, M, Lowndes, J, Child, T, Grifo, JA, Poulton, J, Wells, D Fertil Steril. 2021 Mar. doi: 10.1016/j.fertnstert.2021.01.026	2021
Noninvasive preimplantation genetic testing for aneuploidy exhibits high rates of deoxyribonucleic acid amplification failure and poor correlation with results obtained using trophectoderm biopsy Hanson, BM, Tao, X, Hong, KH, Comito, CE, Pangasnan, R, Seli, E, Jalas, C, Scott, RT Fertil Steril. 2021 Mar. doi: 10.1016/j.fertnstert.2021.01.028	2021
Noninvasive preimplantation genetic testing for aneuploidy in spent culture medium as a substitute for trophectoderm biopsy Rubio, C, Racowsky, C, Barad, DH, Scott, RT, Simon, C Fertil Steril. 2021 Mar. doi: 10.1016/j.fertnstert.2021.02.045	2021
Preimplantation genetic testing to evaluate for mitochondrial deoxyribonucleic acid disease and aneuploidy: a two-birds-with-one-stone approach Hanson, BM, Seli, E Fertil Steril. 2021 Apr. doi: 10.1016/j.fertnstert.2021.03.006	2021
A Natural Xenogeneic Endometrial Extracellular Matrix Hydrogel Toward Improving Current Human in vitro Models and Future in vivo Applications Lopez-Martinez, S, Campo, H, de Miguel-Gomez, L, Faus, A, Navarro, A T, Diaz, A, Pellicer, A, Ferrero, H, Cervello, I, Front Bioeng Biotechnol. 2021 Mar. doi: 10.3389/fbioe.2021.639688	2021
Association between clinical and IVF laboratory parameters and miscarriage after single euploid embryo transfers. Del Carmen Nogales M, Cruz M, de Frutos S, Martínez EM, Gaytán M, Ariza M, Bronet F, Garcia-Velasco JA Reprod Biol Endocrinol. 2021 doi:	2021
Avoiding Asherman’s syndrome: refining our approach to uterine evacuation Martin FFreedman, William DSchlaff Fertility and Sterility . 2021 doi:	2021
Consistency in rates of diagnosis of embryonic mosaicism, segmental abnormalities, and "no call" results among experienced embryologists performing preimplantation genetic testing for aneuploidy. Osman EK, Neal SA, Tiegs AW, Hanson BM, Kim JG, Franasiak JM, Scott RT Jr F S Rep. 2021 doi:	2021
Early Pregnancy Outcomes in Fresh Versus Deferred Embryo Transfer Cycles for Endometriosis-Associated Infertility: A Retrospective Cohort Study Tan, J, Cerrillo, M, Cruz, M, Cecchino, G N, Garcia-Velasco, J A, J Clin Med. 2021 Jan. doi: 10.3390/jcm10020344	2021
Elevated serum progesterone does not impact euploidy rates in PGT-A patients. Pardiñas, ML, Nohales, M, Labarta, E, De Los Santos, JM, Mercader, A, Remohi, J, Bosch, E, De Los Santos, MJ J Assist Reprod Genet. 2021 May. doi: 10.1007/s10815-021-02197-y	2021
Embryos with mosaic results: busting the myth! Dahdouh, EM, Garcia-Velasco, JA Reprod BioMed Online. 2021 Apr. doi: 10.1016/j.rbmo.2021.04.015	2021
Endometrial scratching can be offered outside clinical research setting: let us show you why Vitagliano, A, Di Spiezio Sardo, A, Noventa, M, Carugno, J, Cicinelli, E, Pacheco, A, Vitale, S G, Campo, R, Lagana, A S, Haimovich, S, Cozzolino, M, Greco, P, Hum Reprod. 2021 Apr. doi: 10.1093/humrep/deab060	2021
Evaluation of genome-wide DNA methylation profile of human embryos with different developmental competences. Yang, M, Tao, X, Scott, K, Zhan, Y, Scott, RT, Seli, E Hum Reprod. 2021 Apr. doi: 10.1093/humrep/deab074	2021
Fetal nondiabetic-macrosomia: risk factors for pregnancy adverse outcome and comparison of two growth curves in the prediction of cesarean section Simeone, S, Vannuccini, S, Proietto, R, Serena, C, Ottanelli, S, Rambaldi, M P, Lisi, F, Clemenza, S, Comito, C, Cozzolino, M, Petraglia, F, Mecacci, F, J Matern Fetal Neonatal Med. 2021 24-Feb. doi: 10.1080/14767058.2021.1888918	2021
Frequent loss of heterozygosity in CRISPR-Cas9-edited early human embryos. Alanis-Lobato, G, Zohren, J, McCarthy, A, Fogarty, NME, Kubikova, N, Hardman, E, Greco, M, Wells, D, Turner, JMA, Niakan, KK Proc. Natl. Acad. Sci. USA. 2021 Apr. doi: 10.1073/pnas.2004832117	2021
Mosaic embryos: hiding in plain sight. Scott, R T Fertil Steril. 2021 Jul. doi: 10.1016/j.fertnstert.2021.04.039	2021
Non-invasive PGT Vendrell, X, Escriba, MJ Med Reprod y Embr Clínica. 2021 May. doi: 10.1016/j.medre.2021.100101	2021
Noninvasive prenatal testing in women undergoing in vitro fertilization with preimplantation genetic testing. Klimczak, AM, Seli, E, Scott, RT Curr Opin Obstet Gynecol. 2021 Mar. doi: 10.1097/GCO.0000000000000707	2021
Parameters of poor prognosis in preimplantation genetic testing for monogenic disorders. Van, Der, Kelen, A, Santos-Ribeiro, S, De, Vos, A, Verdyck, P, De, Rycke, M, Berckmoes, V, Tournaye, H, Blockeel, C, De, Vos, M, Hes, FJ, Keymolen, K, Verpoest, W Hum Reprod. 2021 Jun. doi: 10.1093/humrep/deab136	2021
PGT-A for recurrent pregnancy loss: evidence is growing but the issue is not resolved. Dahdouh EM, Balayla J, Garcia-Velasco JA, Kutteh WH Hum Reprod. 2021 doi:	2021
Rescuing monopronucleated-derived human blastocysts: a model to study chromosomal topography and fingerprinting. Soler, N, Bautista-Llacer, R, Escrich, L, Oller, A, Grau, N, Tena, R, Insua, MF, Ferrer, P, Escriba, MJ, Vendrell, X Fertil Steril. 2021 Apr. doi: 10.1016/j.fertnstert.2021.03.038	2021
Serum anti-Müllerian hormone levels are not associated with aneuploidy rates in human blastocysts. Pipari, A, Guillen, A, Cruz, M, Pacheco, A, Garcia-Velasco, JA Reprod BioMed Online. 2021 Apr. doi: 10.1016/j.rbmo.2021.03.006	2021
The concordance rates of an initial trophectoderm biopsy with the rest of the embryo using PGTseq, a targeted next-generation sequencing platform for preimplantation genetic testing-aneuploidy Julia Kim, Xin Tao Julia Kim MD, MPHab Xin Tao PhDc, Michael Cheng MSa Ayesha Steward MSa, Vanessa Guo BAc, Yiping Zhan PhDc, Richard T Scott Jr MD, HCLDab, Chaim Jalas c Fertility and Sterility. 2021 doi:	2021
The cyto-protective effects of LH on ovarian reserve and female fertility during exposure to gonadotoxic alkylating agents in an adult mouse model. Del Castillo LM, Buigues A, Rossi V, Soriano MJ, Martinez J, De Felici M, Lamsira HK, Di Rella F, Klinger FG, Pellicer A, Herraiz S Hum Reprod. 2021 doi:	2021
Uterine natural killer cells: from foe to friend in reproduction Diaz-Hernandez, I, Alecsandru, D, Garcia-Velasco, J A, Dominguez, F, Hum Reprod Update. 2021 2-Feb. doi: 10.1093/humupd/dmaa062	2021
Current Controversies in Prenatal Diagnosis 3: Gene editing should replace embryo selection following PGD Wells, D, Vermeesch, J R, Simpson, J L, Prenat Diagn. 2019 Apr. doi: 10.1002/pd.5442	2019
Three-Dimensional Angiogenic Evaluation of the Effect of Mifepristone in early gestation: pilot study Pellicer-Iborra, B, Herraiz, S, Morales, A, Martinez, S, Garrido, N, Pellicer, A, Gynecol Obstet. 2018 doi:	2018
Detection of segmental aneuploidy and mosaicism in the human preimplantation embryo: technical considerations and limitations. Treff, N, Franasiak, J M, Fertil Steril. 2017 doi:	2017
Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the in vitro fertilization population Juneau, C, Kraus, E, Werner, M D, Franasiak, J M, Morin, S J, Patounakis, G, Molinaro, T A, de Ziegler, D, Scott, R T, Fertil Steril. 2017 Aug. doi: 10.1016/j.fertnstert.2017.05.038	2017
Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe. J Glob Oncol. 4, pp. 1 - 16. 28/06/2017. Rashedi, AS, de, Roo, SF, Ataman, LM, Edmonds, ME, Silva, AA, Scarella, A, Horbaczewska, A, Anazodo, A, Arvas, A, Ramalho, de, Carvalho, B, Sartorio, C, Beerendonk, CCM, Diaz-Garcia, C, Anazodo, A, 2017 doi:	2017
A randomized and blinded comparison of qpcr and NGS based detection of aneuploidy in a cell line mixture model of blastocyst biopsy mosaicism. Goodrich, D, Tao, X, Bohrer, C, Lonczak, A, Xing, T, Zimmerman, R, Zhan, Y, Scott, R T, Treff, NR, Scott, R T, Hum Reprod. 2016 doi:	2016
Aneuploidy screening by array comparative genomic hybridization improves success rates of in vitro fertilization: A multicenter Indian study. Kotdawala, A, Patel, D, Herrero, J, Khajuria, R, Mahajan, N, Banker, M, J Hum Reprod Sci. 2016 doi:	2016
Automatic time-lapse instrument is superior to single-point morphology observation for selecting viable embryos: retrospective study in oocyte donation Aparicio-Ruiz, B, Basile, N, Perez Albala, S, Bronet, F, Remohi, J, Meseguer, M, Fertil Steril. 2016 Nov. doi: 10.1016/j.fertnstert.2016.07.1117	2016
Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy. Ravichandran, K, Guzman, L, Escudero, T, Zheng, X, Colls, P, Jordan, A, Cohen, J, Wells, D, Munne, S, Wells, D, RBM Online. 2016 doi:	2016
Challenges facing contemporary preimplantation genetic screening. Juneau, C, Franasiak, J M, Treff, N, Curr Opin Obstet Gynecol. 2016 doi:	2016
Current controversies in prenatal diagnosis 4: preimplantation genetic screening should be routinely offered to all preimplantation genetic diagnosis cases. Harper, J, Wells, D, Simpson, JL, Prenat Diagn. 2016 doi:	2016
Development and validation of concurrent preimplantation genetic diagnosis for single gene disorders and comprehensive chromosomal aneuploidy screening without whole-genome amplification. Zimmerman, RS, Jalas, C, Tao, X, Fedick, AM, Kim, J, Pepe, RJ, Northrop, LE, Scott, R T, Treff, NR, , Scott, R T, Fertil Steril. 2016 doi:	2016
Embryonic aneuploidy does not differ among genetic ancestry according to continental origin as determined by ancestry informative markers. Franasiak, J M, Olcha, M, Shastri, S, Molinaro, T A, Congdon, H, Treff, NR, Scott, R T, Hum Reprod. 2016 doi:	2016
Embryonic aneuploidy does not differ amongst major ethnicities as determined by genotyping. Franasiak, J M, Olcha, M, Treff, N, Scott, R T, Hum Reprod. 2016 doi:	2016
Kinetics of the early development of uniparental human haploid embryos Escriba, M J, Escrich, L, Galiana, Y, Grau, N, Galan, A, Pellicer, A, Fertil Steril. 2016 May. doi: 10.1016/j.fertnstert.2015.12.139	2016
Mosaicism: “survival of the fittest” versus “no embryo left behind”. Munne, S, Grifo, J, Wells, D, Fertil Steril. 2016 doi:	2016
Next Generation Sequencing Based Comprehensive Chromosome Screening in Mouse Polar Bodies, Oocytes, and Embryos. Treff, NR, Krisher, R, Tao, X, Garnsey, H, Bohrer, C, Silva, E, Landis, J, Taylor, D, Scott, R T, Woodruff, TK, Duncan, FE, Taylor, D, Biol Reprod. 2016 doi:	2016
Pathophysiologic processes have an impact on the plasma metabolomic signature of endometriosis patients Vicente-Munoz, S, Morcillo, I, Puchades-Carrasco, L, Paya, V, Pellicer, A, Pineda-Lucena, A, Fertil Steril. 2016 Dec. doi: 10.1016/j.fertnstert.2016.09.014	2016
Preimplantation genetic diagnosis for infertility. Wells, D, Lewin, J, Textbook of Assisted Reproductive technologies. 2016 doi:	2016
Preimplantation genetic diagnosis: an overview and recent advances. Ben-Nagi, J, Serhal, P, SenGupta, S, Doye, K, Wells, D, Obstet Gynaecol. 2016 doi:	2016
SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts. Treff, NR, Thompson, K, Rafizadeh, M, Chow, M, Morrison, L, Tao, X, Garnsey, H, Reda, CV, Metzgar, TL, Neal, S, Jalas, C, Scott, R T, Forman, E, Reda, CV, J Assist Reprod Genet. 2016 doi:	2016
Técnicas invasivas y no invasivas en el diagnóstico de embriones humanos. Calomarde, C, Carmona, L, Guerra, I, Gutierrez, D, Santana, A, Domingo, J, Rev Iberoam Fert Rep Hum. 2016 doi:	2016
The challenge of embryonic mosaicism in preimplantation genetic screening Scott, R T, Galliano, D, Fertil Steril. 2016 May. doi: 10.1016/j.fertnstert.2016.01.007	2016
The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists Sermon, K, Capalbo, A, Cohen, J, Coonen, E, De Rycke, M, De Vos, A, Delhanty, J, Fiorentino, F, Gleicher, N, Griesinger, G, Grifo, J, Handyside, A, Harper, J, Kokkali, G, Mastenbroek, S, Meldrum, D, Meseguer, M, Montag, M, Munne, S, Rienzi, L, Rubio, C, Scott, K, Scott, R T, Simon, C, Swain, J, Treff, N, Ubaldi, F, Vassena, R, Vermeesch, J R, Verpoest, W, Wells, D, Geraedts, J, Mol Hum Reprod. 2016 Aug. doi: 10.1093/molehr/gaw034	2016
Why do euploid embryos miscarry? A case-control study comparing the rate of aneuploidy within presumed euploid embryos that resulted in miscarriage or live birth using next-generation sequencing. Maxwell, SM, Colls, P, Hodes-Wertz, B, McCulloh, DH, McCaffrey, C, Wells, D, Munne, S, Grifo, J, Fertil Steril. 2016 doi:	2016
24-chromosome PCR for aneuploidy screening. Werner, M D, Scott, R T, Curr Opin Obstet Gynecol. 2015 doi:	2015
Comprehensive chromosome screening improves embryo selection: a meta-analysis. Dahdouh, EM, Balayla, J, Garcia-Velasco, J A, Fertil Steril. 2015 doi:	2015
Deep impact: sequencing embryo biopsy specimens at increasing depth. Spath, K, Wells, D, RBM Online. 2015 doi:	2015
Discordant embryonic aneuploidy testing and prenatal ultrasonography prompting androgen insensitivity syndrome diagnosis. Franasiak, J M, Yao, X, Ashkindaze, E, Rosen, T, Scott, R T, Obstet Gynecol. 2015 doi:	2015
Karyomapping - a comprehensive means of simultaneous monogenic and cytogenetic PGD: comparison with standard approaches in real time for Marfan syndrome. Thornhill, AR, Handyside, AH, Ottolini, C, Natesan, SA, Taylor, J, Sage, K, Harton, G, Cliffe, K, Affara, N, Konstantinidis, M, Wells, D, Griffin, DK, J Assist Reprod Genet. 2015 doi:	2015
Karyomapping allows preimplantation genetic diagnosis of a de-novo deletion undetectable using conventional PGD technology. Gimenez, C, Sarasa, J, Arjona, C, Vilamajo, E, Martinez-Pasarell, O, Wheeler, K, Valls, G, Garcia-Guixe, E, Wells, D, Garcia-Guixe, E, RBM Online. 2015 doi:	2015
Live births following Karyomapping of human blastocysts: experience from clinical application of the method. Konstantinidis, M, Prates, R, Goodall, N, Fischer, J, Tecson, V, Lemma, T, Chua, B, Jordan, A, Armenti, E, Wells, D, Munne, S, Jordan, A, RBM Online. 2015 doi:	2015
Preimplantation genetic screening using comprehensive chromosome screening: evidence and remaining challenges Dahdouh, E M, Balayla, J, Garcia-Velasco, J A, Hum Reprod. 2015 Jun. doi: 10.1093/humrep/dev079	2015
Routine use of next-generation sequencing for preimplantation genetic diagnosis of blastomeres obtained from embryos on day 3 in fresh in~vitro fertilization cycles. Ukaszuk K, Pukszta, S, Wells, D, Cybulska, C, Liss, J, P?ociennik, ?, Kuczy?ski, W, Zabielska, J, Fertil Steril. 2015 doi:	2015
Systematic review on clinical outcomes following selection of human preimplantation embryos with time-lapse monitoring Freour, T, Basile, N, Barriere, P, Meseguer, M, Hum Reprod Update. 2015 Jan-Feb. doi: 10.1093/humupd/dmu054	2015
The time to prevent mendelian genetic diseases from donated or own gametes has come Garrido, N, Bosch, E, Alama, P, Ruiz, A, Fertil Steril. 2015 Oct. doi: 10.1016/j.fertnstert.2015.06.047	2015
The time to prevent mendelian genetic diseases from donated or own gametes has come. Garrido, N, Bosch, E, Alama, P, Ruiz, A, Fertil Steril. 2015 doi:	2015
The use of morphokinetics as a predictor of implantation: a multicentric study to define and validate an algorithm for embryo selection Basile, N, Vime, P, Florensa, M, Aparicio Ruiz, B, Garcia-Velasco, J A, Remohi, J, Meseguer, M, Hum Reprod. 2015 Feb. doi: 10.1093/humrep/deu331	2015
Clinical genetic testing for male factor infertility: current applications and future directions. Hotaling, J M, Carrell, DT, Andrology. 2014 doi:	2014
Clinical utilization of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation. Wells, D, Kaur, K, Grifo, J, Glassner, M, Taylor, JC, Fragouli, E, Munne, S, J Med Genet. 2014 doi:	2014
Embryo aneuploidy screening with CGH arrays in the absence of implantation. Garcia-Herrero, S, Garcia-Herrero, S, Rodrigo, L, Mateu, E, Peinado, V, Milan, M, Campos-Galindo, I, Vera, M, Mercader, A, Bronet, F, Requena, A, Simon, C, Rubio, C, Vera, M, Médecine de la Reproduction. 2014 doi:	2014
Embryo biopsy for aneuploidy detection in the general infertility population. Kaser, D J, Ginsburg, ES, Semin Reprod Med. 2014 doi:	2014
Embryonic aneuploidy: overcoming molecular genetics challenges improves outcomes and changes practice patterns. Franasiak, J M, Scott, R T, Trends Mol Med. 2014 doi:	2014
Human embryonic aneuploidy. Fragouli, E, Wells, D, Encyclopedia of Life Sciences. 2014 doi:	2014
Improved sensitivity to detect recombination using qPCR for Dyskeratosis Congenita PGD. Gueye, N, Jalas, C, Tao, X, Taylor, D, Scott, R T, Treff, NR, J Assist Reprod Genet. 2014 doi:	2014
Increasing the probability of selecting chromosomally normal embryos by time-lapse morphokinetic analysis. Basile, N, Bronet, F, Nogales, MC, Martinez, E, Ariza, M, Agudo, D, Florensa, M, Riqueros, M, Meseguer, M, Riqueros, M, Fertil Steril. 2014 doi:	2014
Increasing the probability of selecting chromosomally normal embryos by time-lapse morphokinetics analysis Basile, N, Nogales Mdel, C, Bronet, F, Florensa, M, Riqueiros, M, Rodrigo, L, Garcia-Velasco, J A, Meseguer, M, Fertil Steril. 2014 Mar. doi: 10.1016/j.fertnstert.2013.12.005	2014
Live birth after embryo transfer in an unresponsive thin endometrium Cruz, F, Bellver, J, Gynecol Endocrinol. 2014 Jul. doi: 10.3109/09513590.2014.900747	2014
Live birth after PGD with confirmation by a comprehensive approach (karyomapping) for simultaneous detection of monogenic and chromosomal disorders. Natesan, SA, Handyside, AH, Thornhill, AR, Ottolini, CS, Sage, K, Summers, MC, Konstantinidis, M, Wells, D, Griffin, DK, RBM Online. 2014 doi:	2014
Next-generation sequencing: the dawn of a new era for preimplantation genetic diagnostics. Wells, D, Fertil Steril. 2014 doi:	2014
Obstetrical and neonatal outcomes from the BEST Trial: Single embryo transfer with aneuploidy screening improves outcomes after in vitro fertilization without compromising delivery rates. Forman, EJ, Hong, KH, Franasiak, J M, Scott, R T, Am J Obstet Gynecol. 2014 doi:	2014
Polar body based aneuploidy screening is poorly predictive of embryo ploidy and reproductive potential. Salvaggio, C, Forman, E, Garnsey, H, Treff, N, Scott, R T, Gueye, I, J Assist Reprod Genet. 2014 doi:	2014
Role of statins in PCOS management Ortega, I, Duleba, AJ, 2014 doi:	2014
Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform. Konstantinidis, M, Alfarawati, S, Hurd, D, Paolucci, M, Shovelton, J, Fragouli, E, Wells, D, Fertil Steril. 2014 doi:	2014
Telomere length and aneuploidy: clinical and biological insights into human preimplantation embryos. Simpson, JL, Wells, D, RBM Online. 2014 doi:	2014
The ethical implications of preimplantation genetic diagnosis. Gronowski, AM, Scott, R T, Caplan, AL, Nelson, LJ, Clin Chem. 2014 doi:	2014
The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening. Franasiak, J M, Forman, EJ, Hong, KH, Werner, M D, Upham, KM, Treff, NR, Fertil Steril. 2014 doi:	2014
Uniparental disomy in the human blastocyst is exceedingly rare. Gueye, N, Devkota, B, Taylor, D, Pfundt, R, Scott, R T, Tref, N, Fertil Steril. 2014 doi:	2014
Additive effect of factors related to assisted conception on the reduction of maternal serum pregnancy-associated plasma protein A concentrations and the increased false-positive rates in first-trimester Down syndrome screening. Bellver, J, Casanova, C, Garrido, N, Lara, C, Remohi, J, Pellicer, A, Serra, V, Fertil Steril. 2013 doi:	2013
Alterations in the gene expression of aneuploid oocytes and associated cumulus cells. Wells, D, Biology and Pathology of the Oocyte. 2013 doi:	2013
Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis. Sokalska, A, Anderson, M, Villanueva, JA, Ortega, I, Bruner-Tran, KL, Osteen, KV, Duleba, AJ, J Clin Endocrinol Metab. 2013 doi:	2013
Embryos whose polar bodies contain isolated reciprocal chromosome aneuploidy are almost always euploid. Forman, EJ, Treff, NR, Stevens, JM, Garnsey, HM, Katz-Jaffe, MG, Scott, R T, Schoolcraft, WB, Hum Reprod. 2013 doi:	2013
Evaluation of targeted next-generation sequencing based preimplantation genetic diagnosis of monogenic disease. Treff, NR, Fedick, A, Tao, X, Devkota, B, Taylor, D, Scott, R T, Fertil Steril. 2013 doi:	2013
False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3 Mir, P, Rodrigo, L, Mercader, A, Buendia, P, Mateu, E, Milan-Sanchez, M, Peinado, V, Pellicer, A, Remohi, J, Simon, C, Rubio, C, J Assist Reprod Genet. 2013 Jan. doi: 10.1007/s10815-012-9918-4	2013
Four-hour quantitative real-time polymerase chain reaction– based comprehensive chromosome screening and accumulating evidence of accuracy, safety predictive values and clinical efficacy. Treff, NR, Scott, R T, Fertil Steril. 2013 doi:	2013
High-density SNP arrays and next generation sequencing for pre-implantation genetic diagnosis. Handyside, A, Wells, D, Gamete and embryo assessment in assisted reproduction: emerging technologies. 2013 doi:	2013
Incidental identification of balanced translocation carrier patients through comprehensive chromosome screening of IVF-derived blastocysts. Treff, NR, Forman, EJ, Katz-Jaffe, MG, Schoolcraft, WB, Levy, B, Scott, R T, J Assist Reprod Genet. 2013 doi:	2013
Metabolomic profiling of oocytes and embryos using spectroscopy: potential clinical use and pitfalls. Sakkas, D, Seli, E, 2013 doi:	2013
Next-generation sequencing for preimplantation genetic diagnosis. Letter to the Editor. Treff, NR, Forman, EJ, Scott, R T, Fertil Steril. 2013 doi:	2013
Obstetric and neonatal outcomes from the BEST Trial: Single embryo transfer with aneuploidy screening improves outcomes after IVF without compromising delivery rates. Forman, EJ, Hong, KH, Franasiak, J M, Scott, R T, Am J Obstet Gynecol. 2013 doi:	2013
Preimplantation genetic diagnosis. Wells, D, Fragouli, E, The Textbook of Clinical Embryology. 2013 doi:	2013
Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials Rubio, C, Bellver, J, Rodrigo, L, Bosch, E, Mercader, A, Vidal, C, De los Santos, M J, Giles, J, Labarta, E, Domingo, J, Crespo, J, Remohi, J, Pellicer, A, Simon, C, Fertil Steril. 2013 Apr. doi: 10.1016/j.fertnstert.2012.11.041	2013
Preimplantation genetic screening. Wells, D, The Textbook of Clinical Embryology. 2013 doi:	2013
Questions about the accuracy of polar body analysis for preimplantation genetic screening. Fragouli, E, Wells, D, Hum Reprod. 2013 doi:	2013
Selecting the optimal time to perform biopsy for preimplantation genetics Scott, KL, Hong, KH, Scott, R T, Fertil Steril. 2013 doi:	2013
The origin and impact of embryonic aneuploidy. Fragouli, E, Alfarawati, S, Spath, K, Jaroudi, S, Sarasa, J, Enciso, M, Wells, D, Hum Genet. 2013 doi:	2013
Treatment of Luteal Phase Defects in Assisted Reproduction. Muñoz, E, Taboas, E, Portela, S, Aguilar, J, Fernandez, I, Muñoz, L, Bosch, E, Curr Drug Targets. 2013 doi:	2013
Alteration of gene expression in human cumulus cells as a potential indicator of oocyte aneuploidy. Fragouli, E, Wells, D, Iager, AE, Kayisli, UA, Patrizio, P, Hum Reprod. 2012 doi:	2012
Aneuploidy Screening for Embryo Selection. Fragouli, E, Wells, D, Semin Reprod Med. 2012 doi:	2012
Blastocyst preimplantation genetic diagnosis of a mitochondrial DNA disorder. Treff, NR, Tao, X, Campos, J, Su, J, Ferry, KM, Levy, B, Scott, R T, Fertil Steril. 2012 doi:	2012
Characteristics of chromosomal abnormalities diagnosed after spontaneous abortions in an infertile population. Werner, M D, Reh, A, Grifo, J, Perle, MA, J Assist Reprod Genet. 2012 doi:	2012
Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLC?) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells. Kashir, J, Konstantinidis, M, Jones, C, Heindryckx, B, Sutter, P, De, Parrington, J, Wells, D, Coward, K, Fertil Steril. 2012 doi:	2012
Chromosomal abnormalities in embryos from couples with a previous aneuploid miscarriage Al-Asmar, N, Peinado, V, Vera, M, Remohi, J, Pellicer, A, Simon, C, Hassold, T, Rubio, C, Fertil Steril. 2012 Jul. doi: 10.1016/j.fertnstert.2012.03.035	2012
Comprehensive chromosome screening and embryo selection: moving toward single euploid blastocyst transfer. Forman, EJ, Hong, KH, Treff, NR, Scott, R T, Semin Reprod Med. 2012 doi:	2012
Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study. Scott, R T, Ferry, KM, Su, J, Tao, X, Scott, KL, Treff, NR, Fertil Steril. 2012 doi:	2012
Delivery of a chromosomally normal child from an oocyte with reciprocal aneuploid polar bodies. Scott, R T, Treff, NR, Stevens, J, Forman, EJ, Hong, KH, Katz-Jaffe, MG, Schoolcraft, WB, J Assist Reprod Genet. 2012 doi:	2012
Development and validation of an accurate quantitative real-time polymerase chain reaction – based assay for human blastocyst comprehensive chromosomal aneuploidy screening. Seminal Contribution. Treff, NR, Tao, X, Ferry, KM, Su, J, Taylor, D, Scott, R T, Fertil Steril. 2012 doi:	2012
Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS Castillo, J C, Garcia-Velasco, J A, Humaidan, P, J Assist Reprod Genet. 2012 Mar. doi: 10.1007/s10815-011-9704-8	2012
Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS. Castillo, JC, Garcia-Velasco, J A, Humaidan, P, J Assist Reprod Genet. 2012 doi:	2012
Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes. Munne, S, Held, KR, Magli, CM, Ata, B, Wells, D, Fragouli, E, Baukloh, V, Fischer, R, Gianaroli, L, Fischer, R, Fertil Steril. 2012 doi:	2012
Methods for comprehensive chromosome screening of oocytes and embryos: capabilities, limitations, and evidence of validity. Scott, R T, J Assist Reprod Genet. 2012 doi:	2012
Preimplantation genetic diagnosis (PGD), preimplantation genetic screening (PGS) and the transfer of in vitro fertilized embryos. Wells, D, Brenner’s Online Encyclopedia of Genetics. 2012 doi:	2012
Single embryo transfer with comprehensive chromosome screening results in improved ongoing pregnancy rates and decreased miscarriage rates. Forman, EJ, Tao, X, Ferry, KM, Taylor, D, Treff, NR, Scott, R T, Hum Reprod. 2012 doi:	2012
Sperm DNA fragmentation index does not correlate with the sperm or embryo aneuploidy rate in recurrent miscarriage or implantation failure patients Bronet, F, Martinez, E, Gaytan, M, Linan, A, Cernuda, D, Ariza, M, Nogales, M, Pacheco, A, San Celestino, M, Garcia-Velasco, J A, Hum Reprod. 2012 Jul. doi: 10.1093/humrep/des148	2012
Successful Live Birth following Preimplantation Genetic Diagnosis for Phenylketonuria in Day 3 Embryos by Specific Mutation Analysis and Elective Single Embryo Transfer. Lavery, S, Abdo, D, JIMD, Reports, Kotrotsou, M, Trew, G, Konstantinidis, M, Wells, D, JIMD Reports. 2012 doi:	2012
Transcriptomic analysis of follicular cells provides information on the chromosomal status and competence of unfertilized oocytes. Fragouli, E, Wells, D, Expert Rev Mol Diagn. 2012 doi:	2012
A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC?) leads to male infertility. Kashir, J, Konstantinidis, M, Jones, C, Lemmon, B, Lee, HC, Hamer, R, Heindryckx, B, Deane, CM, De, Sutter, P, Fissore, RA, Parrington, J, Wells, D, Coward, K, Deane, CM, Hum Reprod. 2011 doi:	2011
Aneuploidy in the Human Blastocyst Fragouli, E, Wells, D, Cytogenet Genome Res. 2011 doi:	2011
Chromosome Abnormalities in the Human Oocyte. Fragouli, E, Wells, D, Delhanty, J, Cytogenet Genome Res. 2011 doi:	2011
Cumulative live-birth rates per total number of embryos needed to reach newborn in consecutive in vitro fertilization (IVF) cycles: a new approach to measuring the likelihood of IVF success Garrido, N, Bellver, J, Remohi, J, Simon, C, Pellicer, A, Fertil Steril. 2011 Jul. doi: 10.1016/j.fertnstert.2011.05.008	2011
Effect of sperm DNA fragmentation on pregnancy outcome depends on oocyte quality Meseguer, M, Santiso, R, Garrido, N, Garcia-Herrero, S, Remohi, J, Fernandez, JL, Fertil Steril. 2011 doi:	2011
Fertility after age 45: From natural conception to assisted reproductive technology and beyond. Forman, EJ, Treff, NR, Scott, R T, Maturitas. 2011 doi:	2011
First births after preimplantation genetic diagnosis of structural chromosome abnormalities using comparative genomic hybridization and microarray analysis. Alfarawati, S, Fragouli, E, Colls, P, Wells, D, Hum Reprod. 2011 doi:	2011
SNP Microarray Based Concurrent Screening of 24 Chromosome Aneuploidy and Unbalanced Translocations in Preimplantation Human Embryos. Treff, NR, Northrop, L, Kasabwala, K, Su, J, Levy, B, Scott, R T, Fertil Steril. 2011 doi:	2011
Telomere DNA deficiency is associated with development of human embryonic aneuploidy. Treff, NR, Su, J, Taylor, D, Scott, R T, PLoS Genet. 2011 doi:	2011
The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy. Fragouli, E, Alfarawati, S, Goodall, N, Sanchez-Garcia, JF, Colls, P, Wells, D, Mol Hum Reprod. 2011 doi:	2011
Therapeutic treatments of mtDNA diseases at the earliest stages of human development. Chiaratti, MR, Meirelles, FV, Wells, D, Poulton, J, Mitochondrion. 2011 doi:	2011
Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos. Gutierrez-Mateo, C, Colls, P, Sanchez-Garcia, J, Escudero, T, Prates, R, Ketterson, K, Wells, D, Munne, S, Fertil Steril. 2011 doi:	2011
Accurate single cell 24 chromosome aneuploidy screening using whole genome amplification and single nucleotide polymorphism microarrays. Treff, NR, Su, J, Tao, X, Levy, B, Scott, R T, Fertil Steril. 2010 doi:	2010
Aneploidies in embryos and spermatozoa from patients with Y chromosome microdelections. Mateu, E, Rodrigo, L, Martinez, MC, Peinedo, V, Delagado, A, MIr, P, Simon, C, Remohi, J, RBM Online. 2010 doi:	2010
Assessing the reproductive competence of individual embryos: a proposal for the validation of new "-omics" technologies. Scott, R T, Treff, NR, Fertil Steril. 2010 doi:	2010
Cytogenetic analysis of human blastocysts with the use of FISH, CGH and aCGH: scientific data and technical evaluation. Fragouli, E, Alfarawati, S, Daphnis, D, Goodall, N, Mania, A, Griffiths, T, Gordon, T, Wells, D, Hum Reprod. 2010 doi:	2010
Embryo aneuploidy and the role of morphological and genetic screening. Wells, D, RBM Online. 2010 doi:	2010
GnRH agonist administration at the time of implantation does not improve pregnancy outcome in intrauterine insemination cycles: a randomized controlled tria Bellver, J, E, Labarta, Bosch, E, Melo, MAB, Vidal, C, Remohi, J, Pellicer, A, Fertil Steril. 2010 doi:	2010
Impacto de un complejo de antioxidantes sobre la fragmentación del ADN espermático en varones infértiles Balmori, C, Areces, C, Pacheco, A, San, Celestino, M, Garcia-Velasco, J A, Rev Int Androl. 2010 doi:	2010
Improved detection of aneuploid blastocysts using a new 12-chromosome FISH test. Munne, S, Fragouli, E, Colls, P, Katz-Jaffe, MG, Schoolcraft, WB, Wells, D, RBM Online. 2010 doi:	2010
Improving FISH diagnosis for preimplantation genetic aneploidy screening Mir, P, Rodrigo, L, Mateu, E, Milan, M, Mercader, A, Buendia, P, Delgado, A, Pellicer, A, Remohi, J, Rubio, C, Hum Reprod. 2010 doi:	2010
Microarrays and CGH for PGD of chromosome abnormalities and gene defects. Munne, S, Harton, G, Held, K, Wells, D, Journal of Reproductive Medicine and Endocrinology. 2010 doi:	2010
Robust embryo identification using polar body single nucleotide polymorphism microarray based DNA fingerprinting. Treff, NR, Su, J, Kasabwala, N, Tao, X, Miller, KA, Scott, R T, Fertil Steril. 2010 doi:	2010
Severe Refractory Hidradenitis Suppurativa in HIV-Positive Patient Successfully Treated with Infliximab. Alecsandru, D, Padilla, B, Aviles, Izquierdo, JA, Fernandez-, Cruz, E, Sanchez-Ramon, S, Archives of Dermatology. 2010 doi:	2010
Single Cell Whole Genome Amplification Technique Impacts the Accuracy of SNP Microarray Based Genotyping and Copy Number Analyses. Treff, NR, Su, J, Tao, X, Northrop, L, Scott, R T, Mol Hum Reprod. 2010 doi:	2010
SNP microarray based 24 chromosome aneuploidy screening demonstrates that cleavage stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts. Northrop, L, Treff, NR, Levy, B, Scott, R T, Mol Hum Reprod. 2010 doi:	2010
SNP microarray based 24 chromosome aneuploidy screening is significantly more consistent than FISH. Treff, NR, Levy, B, Su, J, Northrop, L, Tao, X, Scott, R T, Mol Hum Reprod. 2010 doi:	2010
Surgical management of tubal disease and infertility Coughlan, C, TC, Li, Obstetrics. 2010 doi:	2010
Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes. Munne, S, Wells, D, Cohen, J, Fertil Steril. 2010 doi:	2010
Transcriptomic profiling of human oocytes: association of meiotic aneuploidy and altered oocyte gene expression. Fragouli, E, Bianchi, V, Patrizio, P, Obradors, A, Huang, Z, Borini, A, Delhanty, J, Wells, D, Mol Hum Reprod. 2010 doi:	2010
Transmission of Mitochondrial DNA Diseases and Ways to Prevent Them. Poulton, J, Chiaratti, MR, Meirelles, FV, Kennedy, S, Wells, D, Holt, IJ, PLoS Genet. 2010 doi:	2010
Y chromosome microdeletions, sperm DNA fragmentation and sperm oxidative stress as causes of recurrent spontaneous abortion of unknown etiology. Bellver, J, Meseguer, M, Muriel, L, Garcia-Herrero, S, Barreto, MAM, Garda, AL, Remohi, J, Pellicer, A, Garrido, N, Pellicer, A, Hum Reprod. 2010 doi:	2010
Comparative genomic hybridization of oocytes and first polar bodies from young donors. Fragouli, E, Escalona, A, Gutierrez-Mateo, C, Tormasi, S, Alfarawati, S, Sepulveda, S, Wells, D, Munne, S, RBM Online. 2009 doi:	2009
Birth of a healthy boy after a double factor PGD in a couple carrying a genetic disease and at risk for aneuploidy. Obradors, A, Fernandez, E, Oliver-Bonet, M, Rius, M, de, la, Fuente, A, Wells, D, Benet, J, Navarro, J, Hum Reprod. 2008 doi:	2008
Evaluation of embryo quality by Metabolomics: A new strategy to aid single embryo transfer. Sakkas, D, Morita, H, Yamashita, N, Kato, LO, Botros, L, Roos, P, Seli, E, J Mammal Ova Res. 2008 doi:	2008
Soluble vascular endothelial-cadherin levels correlate with clinical and biological aspects of severe ovarian hyperstimulation syndrome Villasante, A, Pacheco, A, Pau, E, Ruiz, A, Pellicer, A, Garcia-Velasco, J A, Hum Reprod. 2008 Mar. doi: 10.1093/humrep/dem429	2008
Técnica de B-Lynch en el control de la hemorragia posparto Progresos de Obstetricia Blanco, M, Gomez, E, Manosalvas, P, Izquierdo, A, Puente, J M, Hernandez, Garcia, JM, Ginecología. 2008 doi:	2008
Artículo de revisión "Diagnóstico por imagen” Puente, J M, Grañeras, A, Requena, A, Cuadernos de Medicina Reproductiva. 2007 doi:	2007
Single cell diagnosis using comparative genomic hybridization after preliminary DNA amplification still needs more tweaking: too many miscalls. Fragouli, E, Delhanty, JD, Wells, D, Fertil Steril. 2007 doi:	2007
Sperm selection by swim-up in terms of deoxyribonucleic acid fragmentation as measured by the sperm chromatin dispersion test is altered in heavy smokers Viloria, T, Garrido, N, Fernandez, J L, Remohi, J, Pellicer, A, Meseguer, M, Fertil Steril. 2007 Aug. doi: 10.1016/j.fertnstert.2006.11.135	2007
A successful strategy for Preimplantation Genetic Diagnosis of betathalassemia and simultaneous detection of Down's syndrome using multiplex fluorescent PCR. Piyamongkol, W, Vutyavanich, T, Piyamongkol, S, Wells, D, Kunaviktikul, C, Tongsong, T, Chaovisitsaree, S, Saetung, R, Sanguansermsri, T, Saetung, R, J Med Assoc Thai. 2006 doi:	2006
Estudio comparativo de dos medios de cultivo HTF e ISM-1: implicaciones en el fenotipo embrionario y resultados clínicos. Gimeno, L, Lopez, MA, Meseguer, M, Santos, JM, Pellicer, A, Remohi, J, Santos, MJ, Revista Iberoamericana de Fertilidad y Reproducción Humana. 2006 doi:	2006
Heteroparental blastocyst production from microsurgically corrected tripronucleated human embryos Escriba, M J, Martin, J, Rubio, C, Valbuena, D, Remohi, J, Pellicer, A, Simon, C, Fertil Steril. 2006 Dec. doi: 10.1016/j.fertnstert.2006.04.047	2006
Heteroparental blastocyst production from microsurgically corrected tripronucleated human embryos. Escriba, M J, Martin, J, Rubio, C, Valbuena, D, Remohi, J, Pellicer, A, Simon, C, Fertil Steril. 2006 doi:	2006
J.Ultrastructure of preimplantation genetic diagnosis-derived human blastocysts grown in a coculture system after vitrification. Escriba, M J, Escobedo-Lucea, C, Mercader, A, De, Los, Santos, MJ, Pellicer, A, Remohi, J, Fertil Steril. 2006 doi:	2006
Prenatal management of placental chorioangioma: value of the middle cerebral artery peak systolic velocity. Escribano, D, Galindo, A, Arbues, J, Puente, J M, De, la, Fuente, P, Fetal Diagn Ther. 2006 doi:	2006
Use of Real-Time Polymerase Chain Reaction to Measure Gene Expression in Single Cells. Wells, D, Single Cell Diagnostics: Methods and Protocols. 2006 doi:	2006
Association of abnormal morphology and altered gene expression in human preimplantation embryos. Wells, D, Bermúdez, MG, Steuerwald, N, Malter, HE, Thornhill, AR, Cohen, J, Fertil Steril. 2005 doi:	2005
Etiologia, diagnostico y manejo del hidrops fetal: revision de 140 casos Arbues, J, Galindo, A, Puente, J M, Grañeras, A, De, la, Fuente, P, Prog Obstet Ginecol. 2005 doi:	2005
Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation development. Wells, D, Bermudez, MG, Steuerwald, N, Thornhill, AR, Walker, DL, Malter, H, Delhanty, JDA, Cohen, J, Hum Reprod. 2005 doi:	2005
Isolated unilateral pulmonary agenesis. Early prenatal diagnosis and long-term follow up. Arbues, J, Galindo, A, Rasero, M, Orbea, C, Puente, J M, De, la, Fuente, P, J Ultrasound Med. 2005 doi:	2005
Near Speed-of-Light On-Chip Interconnects Using Pulsed Current-Mode Signaling. Jose, AP, Patounakis, G, Shepard, KL, 2005 Symposium on VLSI Circuits. 2005 doi:	2005
The singleton, term gestation, and live birth rate per cycle initiated: a 1-year experience in in vitro fertilization cycles with native and donated oocytes Bellver, J, Albert, C, Soares, S R, Alvarez, C, Pellicer, A, Fertil Steril. 2005 May. doi: 10.1016/j.fertnstert.2004.11.047	2005
Advances in preimplantation genetic diagnosis. Wells, D, Eur J Obstet Gynecol Reprod Biol. 2004 doi:	2004
Reliability of comparative genomic hybridization to detect chromosome abnormalities in first polar bodies and metaphase II oocytes. Gutierrez-Mateo, C, Wells, D, Benet, J, Sanchez-Garcia, JF, Bermúdez, MG, Belil, I, Egozcue, J, Munne, S, Navarro, J, Munne, S, Hum Reprod. 2004 doi:	2004
Detailed investigation of factors influencing amplification efficiency and allele drop-out in single cell PCR: implications for preimplantation genetic diagnosis. Piyamongkol, W, Bermudez, MG, Harper, JC, Wells, D, Mol Hum Reprod. 2003 doi:	2003
Rabbit and pig ear skin sample cryobanking: effects of storage time and temperature of the whole ear extirpated immediately after death. Silvestre, MA, Saeed, AM, Cervera, RP, Escriba, M J, Garcia-Ximenez, F, Theriogenology. 2003 doi:	2003
Single-cell sequencing and mini-sequencing for preimplantation genetic diagnosis. Bermudez, MG, Piyamongkol, W, Tomaz, S, Dudman, E, Sherlock, JK, Wells, D, Prenat Diagn. 2003 doi:	2003
First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy. Wells, D, Escudero, T, Levy, B, Hirschhorn, K, Delhanty, JDA, Munne, S, Fertil Steril. 2002 doi:	2002
New techniques on embryo manipulation. Escriba, M J, Valbuena, D, Remohi, J, Pellicer, A, Simon, C, J Reprod Immunol. 2002 doi:	2002
Preimplantation genetic diagnosis for single gene disorders: experience with five single gene disorders. Harper, JC, Wells, D, Piyamongkol, W, Abou-Sleiman, P, Apessos, A, Ioulianos, A, Davis, M, Doshi, A, Serhal, P, Ranieri, M, Rodeck, C, Delhanty, JDA, Prenat Diagn. 2002 doi:	2002
Preimplantation genetic diagnosis: an alternative to prenatal diagnosis. Delhanty, JDA, Wells, D, Expert Rev Mol Diagn. 2002 doi:	2002
The "vanishing embryo" phenomenon in an oocyte donation programme Rodriguez-Gonzalez, M, Serra, V, Garcia-Velasco, J A, Pellicer, A, Remohi, J, Hum Reprod. 2002 Mar. doi: 10.1093/humrep/17.3.798	2002
The "vanishing embryo" phenomenon in an oocyte donation programme. Rodriguez-Gonzalez, M, Serra, V, Garcia-Velasco, J A, Pellicer, A, Remohi, J, Fertil Steril. 2002 doi:	2002
Towards a comprehensive analysis of chromosomes and DNA sequences in human embryos. Wells, D, Advances in Infertility Treatment (Monduzzi Editore. 2002 doi:	2002
Viable offspring derived from cryopreserved haploid rabbit parthenotes Garcia-Ximenez, F, Escriba, M J, Theriogenology. 2002 doi:	2002
Vitrification and rapid freezing of rabbit fetal tissues and skin samples from rabbits and pigs. Silvestre, MA, Saeed, AM, Escriba, M J, Garcia-Ximenez, F, Theriogenology. 2002 doi:	2002
A successful strategy for preimplantation genetic diagnosis of myotonic dystrophy using multiplex fluorescent PCR. Piyamongkol, W, Harper, JC, Sherlock, JK, Doshi, A, Serhal, PF, Delhanty, JDA, Wells, D, Prenat Diagn. 2001 doi:	2001
Acrocentric chromosome disomy is increased in spermatozoa from fathers of Turner syndrome patients Soares, S R, Vidal, F, Bosch, M, Martinez-Pasarell, O, Nogues, C, Egozcue, J, Templado, C, Hum Genet. 2001 doi:	2001
Comparison of the effect of two different handling media on rabbit zygote developmental ability Escriba, M J, Silvestre, MA, Saeed, AM, Garcia-Ximenez, F, Reprod Nutr Dev. 2001 doi:	2001
Future developments in preimplantation genetic diagnosis. Harper, J, Wells, D, Preimplantation Genetic Diagnosis. 2001 doi:	2001
Genetic alterations in gastric cancers from British patients. Sud, R, Wells, D, Talbot, IC, Delhanty, JDA, Cancer Genet Cytogenet. 2001 doi:	2001
Numerical chromosome abnormalities in the spermatozoa of the fathers of children with trisomy 21 of paternal origin: generalised tendency to meiotic non-disjunction. Soares, S R, Templado, C, Blanco, J, Egozcue, J, Vidal, F, Hum Genet. 2001 doi:	2001
PGD protocols using multiplex fluorescent PCR. Piyamongkol, W, Harper, CJ, Delhanty, JDA, Wells, D, RBM Online. 2001 doi:	2001
Preimplantation genetic diagnosis: applications for molecular medicine. Wells, D, Delhanty, JDA, Trends Mol Med. 2001 doi:	2001
Preimplantation genetic diagnostic protocols for alpha- and beta-thalassaemias using multiplex fluorescent PCR. Piyamongkol, W, Harper, JC, Delhanty, JDA, Wells, D, Prenat Diagn. 2001 doi:	2001
A successful strategy for preimplantation diagnosis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency. Ioulianos, A, Wells, D, Harper, JC, Delhanty, JDA, Prenat Diagn. 2000 doi:	2000
Comparative Genomic Hybridization Reveals Extensive Variation Among Different MCF-7 Cell Stocks. Jones, C, Payne, J, Wells, D, Delhanty, JDA, Lakhani, SR, Kortenkamp, A, Cancer Genet Cytogenet. 2000 doi:	2000
Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization. Wells, D, Delhanty, JDA, Mol Hum Reprod. 2000 doi:	2000
Deletion and duplication of the adenomatous polyposis coli gene resulting from an interchromosomal insertion involving 5 (q22q23.3) in the father. Hastings, RJ, Svennevik, EC, Setterfield, B, Wells, D, Delhanty, JDA, Mackinnon, H, J Med Genet. 2000 doi:	2000
Vitrification and rapid-freezing of cumulus cells from rabbits and pigs. Saeed, AM, Escriba, M J, Silvestre, MA, Garcia-Ximenez, F, Theriogenology. 2000 doi:	2000
Positive outcome after preimplantation diagnosis of aneuploidy in human embryos. Munne, S, Magli, C, Cohen, J, Morton, P, Sadowy, S, Gianaroli, L, Tucker, M, Marquez, C, Sable, D, Ferraretti, AP, Massey, JB, Scott, R T, Hum Reprod. 1999 doi:	1999
Preimplantation genetic diagnosis of cancer: familial adenomatous polyposis coli (FAPC). Ao, A, Wells, D, Handyside, AH, Winston, RML, Delhanty, JDA, J Assist Reprod Genet. 1998 doi:	1998
Strategies for preimplantation genetic diagnosis of single gene disorders by DNA amplification. Wells, D, Sherlock, JK, Prenat Diagn. 1998 doi:	1998
Detection of haemoglobinopathies and chromosome aneuploidy from minute DNA samples using multiplex PCR. Sherlock, J, Cirigliano, V, Petrou, M, Wells, D, Adinolfi, M, Infertility and Assisted Reproductive Technology - From Research to Therapy. 1997 doi:	1997
Genetic diagnosis before implantation. Delhanty, JDA, Wells, D, Harper, JC, BMJ. 1997 doi:	1997
APC gene mutation and DNA microsatellite instability in pancreatic cancers of UK origin. See, CG, Sud, R, Wells, D, Bowles, L, Ding, S, Habib, N, Delhanty, JDA, GI Cancer 2. 1996 doi:	1996
Preimplantation genetic diagnosis of beta-thalassaemia. El-Hashemite, N, Wells, D, Delhanty, JDA, Lancet. 1996 doi:	1996
Correlation of loss of heterozygosity with cytogenetic analysis using g-banding and fluorescence in situ hybridization in aneuploid cultures from two human testicular germ-cell tumors. Al-Jehani, RMA, Wells, D, Fox, M, Parrington, JM, Cancer Genet Cytogenet. 1995 doi:	1995
Rapid detection of rare variants and common polymorphisms in the APC gene by PCR-SSCP for presymptomatic diagnosis and showing allele loss. Gayther, SA, Sud, R, Wells, D, Tsioupra, K, Delhanty, JD, J Med Genet. 1995 doi:	1995

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