Marcos Meseguer, Ph.D.

Biografía

Dr. Marcos Meseguer received his B.Sc. degree in Biological Sciences from the University of Valencia in Spain. He then performed a pre-doctoral fellowship in St Mary´s Hospital, Manchester University, United Kingdom, and received his Ph.D. Degree in Obstetrics and Gynecoloy and the European Doctor Degree in 2002 from the University of Valencia, Spain. He has also a master degree in Research Methods; Design and Statistics from Universidad Autónoma de Barcelona, Spain.
Dr.Meseguer is currently the Scientific Supervisor and Senior Embryologist at the IVI Valencia IVF unit. Previously, he was co-Director of the Andrology Laboratory at the Instituto Valenciano de Infertilidad (IVI).

Dr. Meseguer has received the Prize Paper Award of the American Society of Reproductive Medicine, three times the Lalor Foundation International Award from the American Society of Andrology, three times the research award from the Spanish Society of Fertility and four times the research award from the Spanish Society of Embrology. He received the Robert Edwards prize paper award from RBM online and is ASRM star award winner. The primary areas of his research are embryology and male infertility.
As Principal Investigator, his work has been funded through 16 projects sponsored by the Spanish Government, including five EUREKA projects (granted to high quality technological projects) supported by the European Community. He has one international patent.
He has published over 145 scientific articles, with 5400 citations and h-index of 43, including the most cited paper in Human Reproduction during 2013. Additionally published 50 reviews or book chapters, edited the first time-lapse book and made more than 500 presentations at national and international congresses. He has been the Director of 13 Doctoral Thesis all qualified with «Cum Laude», and currently is directing 6 PhD candidates. In addition, he is also Statistics Advisor of Equipo IVI and Associate Professor of the Master’s in Biotechnology at University of Valencia.

Formación

BS	University of Valencia (1998)
PhD in Obstetrics and Gynecology	University of Valencia (2002)
European Doctor Degree in Biological Sciences	University of Valencia (2002)
Master Statistics and Research Methods	University of Barcelona (2009)

Honores y reconocimientos

Honorable Member Spanish Society of Embryology	2017
ASRM star award winner	2017
Research award from the Spanish Society of Embryology	2015
Robert Edwards prize paper award from RBM online	2014
Spanish Society of Fertility Research Award	2014
Research award from the Spanish Society of Embryology	2013
Spanish Society of Fertility Research Award	2012
Research award from the Spanish Society of Embryology	2011
Research award from the Spanish Society of Embryology	2009
Lalor Foundation International Award from the American Society of Andrology	2008
Lalor Foundation International Award from the American Society of Andrology	2005
Lalor Foundation International Award from the American Society of Andrology	2003
Prize paper Journal of Spanish Society of Fertility	2002

Publicaciones

A Randomized Controlled Intervention Trial with Danazol to Improve Telomeric and Fertility Parameters in Women with Diminished Ovarian Reserve: A Pilot Study.
Córdova-Oriz I, Kohls G, Iglesias C, Polonio AM, Chico-Sordo L, Toribio M, Meseguer M, Varela E, Pellicer A, García-Velasco JA

Womens Health Rep (New Rochelle). 2023 Jul 4;4(1):305-318. doi: 10.1089/whr.2023.0013. eCollection 2023. . 2023 doi:

Better late than never: the clinical value of Day 7 blastocysts.
Fraire-Zamora JJ, Serdarogullari M, Sharma K, Ammar OF, Mincheva M, Macklon N, Pujol A, Capalbo A, Meseguer M, Liperis G

Hum Reprod. 2023 Jan 4:deac269. doi: 10.1093/humrep/deac269. Online ahead of print.. 2023 doi:

Clinical validation of an automatic classification algorithm applied on cleavage stage embryos: analysis for blastulation, euploidy, implantation, and live-birth potential.
Valera MA, Aparicio-Ruiz B, Pérez-Albalá S, Romany L, Remohí J, Meseguer M

Hum Reprod. 2023 Apr 5:dead058. doi: 10.1093/humrep/dead058. Online ahead of print.. 2023 doi:

Deep learning system for classification of ploidy status using time-lapse videos.
Paya E, Pulgarín C, Bori L, Colomer A, Naranjo V, Meseguer M

F S Sci. 2023 Jun 30:S2666-335X(23)00035-6. doi: 10.1016/j.xfss.2023.06.002. Online ahead of print.. 2023 doi:

Should embryo rebiopsy be considered a regular strategy to increase the number of embryos available for transfer?
Nohales M, Coello A, Martin A, Insua F, Meseguer M, de Los Santos MJ

J Assist Reprod Genet. 2023 Jul 11. doi: 10.1007/s10815-023-02875-z. Online ahead of print.. 2023 doi:

Using Unlabeled Information of Embryo Siblings from the Same Cohort Cycle to Enhance In Vitro Fertilization Implantation Prediction.
Tzukerman N, Rotem O, Shapiro MT, Maor R, Meseguer M, Gilboa D, Seidman DS, Zaritsky A

Adv Sci (Weinh). 2023 Jul 28:e2207711. doi: 10.1002/advs.202207711. Online ahead of print.. 2023 doi:

#ESHREjc report: seeing is believing! How time lapse imaging can improve IVF practice and take it to the future clinic.
Serdarogullari M, Ammar OF, Sharma K, Kohlhepp F, Montjean D, Meseguer M, Fraire-Zamora JJ

Hum Reprod. 2022 Apr 11:deac072. Online ahead of print. 2022 doi: 10.1093/humrep/deac072

A non-invasive artificial intelligence approach for the prediction of human blastocyst ploidy: a retrospective model development and validation study.
Barnes J, Brendel M, Gao VR, Rajendran S, Kim J, Li Q, Malmsten JE, Sierra JT, Zisimopoulos P, Sigaras A, Khosravi P, Meseguer M, Zhan Q, Rosenwaks Z, Elemento O, Zaninovic N, Hajirasouliha I

Lancet Digit Health. 2023 Jan;5(1):e28-e40. doi: 10.1016/S2589-7500(22)00213-8.. 2022 doi:

A propensity score-based, comparative study assessing humid and dry time-lapse incubation, with single-step medium, on embryo development and clinical outcomes.
Valera MÁ, Albert C, Marcos J, Larreategui Z, Bori L, Meseguer M

Hum Reprod.. 2022 doi: 10.1093/humrep/deac165

The higher the score, the better the clinical outcome: retrospective evaluation of automatic embryo grading as a support tool for embryo selection in IVF laboratories.
Bori L, Meseguer F, Valera MA, Galan A, Remohi J, Meseguer M

Hum Reprod. 2022 Apr 18:deac066. Online ahead of print. 2022 doi: 10.1093/humrep/deac066

Fertility technologies and how to optimize laboratory performance to support the shortening of time to birth of a healthy singleton: a Delphi consensus.
Coticchio G, Behr B, Campbell A, Meseguer M, Morbeck DE, Pisaturo V, Plancha CE, Sakkas D, Xu Y, D'Hooghe T, Cottell E, Lundin K

J Assist Reprod Genet. 2021 May;38(5):1021-1043. doi: 10.1007/s10815-021-02077-5. Epub 2021 Feb 18.. 2021 doi:

In vitro fertilization and andrology laboratories in 2030.
Simon C, Campbell A, Gardner DK, Meseguer M, Miller KA, Montag M, Palermo GD, Cheung S, Keating D, Xie P, Rosenwaks Z, Rienzi L, Innocenti F, Cimadomo D, Ubaldi FM, Sakkas D, Tucker MJ, Nel-Themaat L

Fertil Steril. 2021 Jul;116(1):2-3. doi: 10.1016/j.fertnstert.2021.05.089.. 2021 doi:

"Quality is not an act, it is a habit." Reflection on the role of the fertilization rate in the quality control strategies of assisted reproduction treatments.
Valera MÁ, Meseguer M

Fertil Steril. 2021 doi:

Blastocyst formation is similar in obese and normal weight women: a morphokinetic study.
Bellver J, Brandão P, Alegre L, Meseguer M

Hum Reprod. 2021 doi:

In vitro fertilization and andrology laboratory in 2030: expert visions.
Campbell A, Gardner DK, Meseguer M, Miller KA, Montag M, Palermo GD, Cheung S, Keating D, Xie P, Rosenwaks Z, Rienzi L, Innocenti F, Cimadomo D, Ubaldi FM, Sakkas D, Tucker MJ, Nel-Themaat L, Simon C

Fertil Steril. 2021 Jul;116(1):4-12. doi: 10.1016/j.fertnstert.2021.05.088.. 2021 doi:

Good practice recommendations for the use of time-lapse technology†.
ESHRE Working group on Time-lapse technology, Apter S, Ebner T, Freour T, Guns Y, Kovacic B, Le Clef N, Marques M, Meseguer M, Montjean D, Sfontouris I, Sturmey R, Coticchio G

Hum Reprod Open. 2020 Mar 19;2020(2):hoaa008. doi: 10.1093/hropen/hoaa008. eCollection 2020.. 2020 doi:

Time of morulation and trophectoderm quality are predictors of a live birth after euploid blastocyst transfer: a multicenter study.
Rienzi L, Cimadomo D, Delgado A, Minasi MG, Fabozzi G, Gallego RD, Stoppa M, Bellver J, Giancani A, Esbert M, Capalbo A, Remohì J, Greco E, Ubaldi FM, Meseguer M

Fertil Steril. 2019 Dec;112(6):1080-1093.e1. doi: 10.1016/j.fertnstert.2019.07.1322.. 2019 doi:

The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.
Sermon K, Capalbo A, Cohen J, Coonen E, De Rycke M, De Vos A, Delhanty J, Fiorentino F, Gleicher N, Griesinger G, Grifo J, Handyside A, Harper J, Kokkali G, Mastenbroek S, Meldrum D, Meseguer M, Montag M, Munné S, Rienzi L, Rubio C, Scott K, Scott R, Simon C, Swain J, Treff N, Ubaldi F, Vassena R, Vermeesch JR, Verpoest W, Wells D, Geraedts J

Mol Hum Reprod. 2016 Aug;22(8):845-57. doi: 10.1093/molehr/gaw034. Epub 2016 Jun 2. . 2016 doi:

Presentaciones

Tejera A Alegre L Mifsud A De los Santos JM Esbert M Meseguer M P-21 ASSISTED HATCHING (AH) IN COLLAPSED BLASTOCYSTS IS ABLE TO RESTORE THE IMPLANTATION RATES: A RETROSPECTIVE STUDY. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Bori L Paya E Valera MA Remohi JA Valery Naranjo Meseguer M P-79 ARTIFICIAL NEURAL NETWORKS APPLIED FOR PREDICTION OF THE IMPLANTATION POTENTIAL BY USING EMBRYO MORPHOLOGY DYNAMICS. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Alegre L Bori L Valera MA Gouveia Nogueira MF André Satoshi Ferreira Celso Rocha J Meseguer M P-83 FIRST APPLICATION OF ARTIFICIAL NEURONAL NETWORKS FOR HUMAN LIVE BIRTH PREDICTION ON GERI TIME-LAPSE MONITORING SYSTEM BLASTOCYST IMAGES.. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Cozzolino M Garcia-Velasco JA Meseguer M Pellicer A Bellver J O-153 OBESE WOMEN PRESENT AN INCREASED RISK OF MISCARRIAGE AFTER EUPLOID EMBRYO TRANSFER. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Romany L Viloria T Aparicio-Ruiz B Diana Beltrán Remohi JA Meseguer M P-81 MACS TECHNOLOGY APPLIED FOR SPERM SELECTION IMPROVES BLASTOCYST QUALITY; A CONTINIOUS EMBRYO MONITORING STUDY.. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Perez-Albala S Aparicio-Ruiz B Bori L Remohi JA Viloria T Meseguer M P-99 EMBRYO AUTOMATIC DIAGNOSTIC TEST; BLASTULATION,ANEUPLOIDY AND IMPLANTATION RATE PREDICTION. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Valera MA Albert C Bori L Alegre L Viloria T Meseguer M P-12 HUMID VS DRY CULTURE: DOES RELATIVE HUMIDITY AFFECT THE MORPHOKINETICS OF IN VITRO CULTURED EMBRYOS?. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Labarta E Rodriguez-Varela C Meseguer M Bori L Delgado A Mercader A Aparicio-Ruiz B Bosch E P-1015 COMPARISON OF THE EMBRYO QUALITY OBTAINED AFTER AN UNSTIMULATED AND STIMULATED CYCLE IN THE SAME INFERTILE PATIENT UNDERGOING IN VITRO FERTILIZATION.. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Meseguer M 0-164 The application of artificial oocyte activation (AOA) in patients with previous unsuccessful attempt increases the ongoing pregnancy per treatment but not per transfer,a multivariable study.. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology, Copenhagen,Denmark, July 5-8,2020

Valera MA García C Bori L Meseguer M Ferrando M Pellicer A Mol BW Valbuena D Comparison of clinical results of embryo culturing using last generation incubators: is there a better option?. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology, Copenhagen,Denmark, July 5-8,2020