Emre Seli, M.D.

Biography

Emre Seli, MD, is Research Director at IVI RMA Global and Professor of Obstetrics, Gynecology, and Reproductive Sciences at Yale School of Medicine. Dr. Seli received his medical degree from the University of Istanbul and completed his Residency in Obstetrics and Gynecology at Yale University. His postdoctoral training included a fellowship in Reproductive Endocrinology and Infertility as well as a research fellowship in molecular biology, both at Yale University.

The primary focus of his research program is to understand and treat infertility. His laboratory characterized mechanisms regulating translational activation of gene expression in the oocyte. Dr. Seli and his colleagues also made seminal contributions to our understanding of oocyte and embryo competence in IVF and the potential role of non-invasive diagnostic technologies in this context. Dr. Seli is the recipient of many National Institutes of Health (NIH) and pharmaceutical industry-sponsored research grants. He has trained more than 50 pre- and post-doctoral fellows, published more than 100 scientific articles, and received numerous research awards, including the Ira and Ester Rosenwaks New Investigator Award from the American Society for Reproductive Medicine (ASRM), and the President’s Achievement Award from the Society for Reproductive Investigation (SRI). Dr. Seli’s current research focuses on determinants of oocyte and embryo health, and mechanisms of ovarian ageing.

Dr. Seli is actively involved in professional societies and scientific journals. He served as the Program Director for SRI 2016, where he is now the Program Committee Chair (2016-2021). He has also been a member of the ASRM Research Committee for the past 5 years, and served as the member of the SSR Program Committee, where he organized the Ovarian Workshop in 2016 and 2018. He is/was associate editor for Molecular Human Reproduction, Reproductive Sciences, Journal of Assisted Reproduction and Genetics, and Reproductive Biomedicine Online and is currently co-editor of Current Opinion in Obstetrics and Gynecology.

As an educator, Dr. Seli delivered more than 150 invited lectures nationally and internationally, and he is the recipient of the “Association of Professors of Gynecology and Obstetrics (APGO) Excellence in Teaching Award” based on evaluations of his lectures by Yale Medical Students. Dr. Seli edited four books (Non-invasive Management of Gynecologic Disorders, Infertility, Fertility Preservation, and Human Gametes and Pre-implantation Embryos: Assessment and Diagnosis), and is currently co-authoring the 9th edition of the most acclaimed book in the field, “Speroff’s Clinical Gynecologic Endocrinology and Infertility“.


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Education and Training

M.D. Istanbul Medical School, Istanbul, Turkey (M.D.) (1992)
Residency Obstetrics, Gynecology, and Reproductive Sci. Yale School of Medicine (2001)
Fellowship Reproductive Endocrinology and Infertility Yale School of Medicine (2004)

Honors and recognition

SRI/Pfizer President’s Presenter Award, Society for Reproductive Investigation (SRI) to Scott Morin (mentor) 2018
SRI/Pfizer President’s Presenter Award, Society for Reproductive Investigation (SRI) to Man Zhang (mentor) 2018
Best Doctors in America 2017
Star Award, American Society for Reproductive Medicine (ASRM) 2017
SRI/Pfizer President’s Presenter Award, Society for Reproductive Investigation (SRI) to Tianren Wang (mentor) 2017
ASRM In-Training Award for Research. American Society for Reproductive Medicine (ASRM) to Tianren Wang (mentor) 2016
Best Doctors in America 2016
Star Award, American Society for Reproductive Medicine (ASRM) 2016
President’s Achievement Award, Society for Reproductive Investigation (SRI) 2016
SRI/Pfizer President’s Presenter Award, Society for Reproductive Investigation (SRI) to Katie Lowther (mentor) 2016
SRI/Pfizer President’s Presenter Award, Society for Reproductive Investigation (SRI) to Elnur Babayev (mentor) 2016
Best Doctors in America 2015
Star Award, American Society for Reproductive Medicine (ASRM) 2015
Best New Investigator Poster Award, Society for Reproductive Investigation (SRI) to Katie Lowther (mentor) 2015
Master of Arts, Privatim. Yale University, New Haven, CT, USA 2015
Excellence in Teaching Award, Association of Professors of Gynecology and Obstetrics (APGO) and Department of Obstetrics and Gynecology, Yale School of Medicine 2013
Ira and Ester Rosenwaks New Investigator Award, American Society for Reproductive Medicine (ASRM) 2009
Co-investigator for Basic Science Award, European Society of Human Reproduction and Embryology (ESHRE) 2008
Faculty Teaching Award for Medical Student Education, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine. 2007
Lee Buxton Award for Medical Student Education, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine 2006
Mentored Clinical Scientist Development (K08) Award, National Institute of Health (NIH) 2003
President’s Presenter Award, Society for Reproductive Investigation (formerly Society for Gynecologic Investigation) (SRI) 2002
John J. Meehan-Clifford R. Miller Award for academic excellence, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine 2001
Residents of Excellence Award for outstanding resident research by a graduating resident, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine 2001
The Society of Laparoendoscopic Surgeons “Outstanding Laparo-endoscopic Resident Surgeon Award” 2001
President’s Presenter Award, Society for Reproductive Investigation (formerly Society for Gynecologic Investigation) (SRI) 2000
ACOG/Novartis Fellowship Award for Research in Endocrinology of Postreproductive Woman 1999-2000
NAMS/Solvay Pharmaceuticals Corporation Fellowship Grant Award. 1999
Ranked top 1% in the national residency entrance examination (among 14,000 medical school graduates) in Turkey 1993
MISC European scholarship award for visiting student at Free University, Amsterdam, Holland. 1990
Sabanci scholarship for outstanding first year medical student. 1985
Ranked top 1% in nationwide university entrance examination (among 600,000) in Turkey 1984

Publications


  • Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos.
    Wang T,Babayev E, Jiang Z,Li G, Zhang M, Esencan E, Horvath T, Seli E.
    Aging Cell. 2018 May 30:e12784. doi: 10.1111/acel.12784.

  • Translational Regulation of Gene Expression During Oogenesis and Pre-Implantation Embryo Development.
    Esencan E, Seli E.
    In P.C.K. Leung and J. Qiao eds. Human Reproductive and Prenatal Genetics, Elsevier San Diego, CA, 2018.

  • Embryonic poly(A)-binding protein (EPAB) is important at the preantral stage of mouse folliculogenesis for oocyte-somatic communication.
    Lowther KM, Favero F, Yang C, Taylor HS, Seli E.
    Biol Reprod, 96:341-51, 2017.

  • Endocrine causes of implantation failure.
    Morin S, Ata B, Seli E.
    In: J Franasiak, R.T. Scott eds. Recurrent implantation failure. Springer/Humana Press, Berlin, Germany, 2017.

  • Mitochondrial dysfunction and ovarian senescence.
    Wang T, Zhang M, Jiang Z, Seli E.
    Am J Reprod Immunol, 77(5), 2017.

  • Freeze all strategy in assisted reproduction: why it is not warranted?
    Ata B, Seli E.
    Curr Opin Obstet Gynecol, 28:149-50, 2017.

  • Cross-talk between FSH and endoplasmic reticulum stress: a mutually suppressive relationship.
    Babayev E, Favero, F, Lalioti MD, Seli E.
    Reprod Sci, 23:352-64, 2016.

  • Aging is associated with changes in mitochondrial dynamics, function and mtDNA quantity.
    Babayev E, Wang T, Szigeti-Buck K, Lowther K, Taylor HS, Horvath T, Seli E.
    Maturitas, 93:121-130, 2016.

  • Mitochondrial DNA as a biomarker for in vitro fertilization (IVF) outcome.
    Seli E.
    Curr Opin Obstet Gynecol, 28:158-63, 2016.

  • Same-sex reproduction: Medical treatment options and psychosocial considerations.
    Greenfeld D, Seli E.


  • IVF: progress through technology development.
    Garcia-Velasco J, Seli E.
    Curr Opin Obstet Gynecol, 28:149-50, 2016.

  • Poor ovarian response in women undergoing in vitro fertilization (IVF) is associated with altered micro RNA expression in cumulus cells.
    Karakaya C, Guzeloglu-Kayisli O, Uyar A, Kallen AN, Babayev E, Bozkurt N, Unsal E, Karabacak O, Seli E.
    Fertil Steril, 103:1469-76, 2015.

  • Embryonic poly(A)-binding protein (EPAB) is required for EGF signaling and cumulus expansion in female mice.
    Yang C, Lowther KM, Lalioti MD, Seli E.
    Endocrinology, 157:405-16, 2015.

  • Oocyte mitochondrial function and reproduction.
    Babayev E, Seli E.
    Curr Opin Obstet Gynecol, 27:175-81, 2015.

  • IVF: a short but exciting story.
    Garcia-Velasco J, Seli E.
    Curr Opin Obstet Gynecol, 27:165-6, 2015.

  • Strategies for controlled ovarian stimulation in the setting of ovarian ageing.
    Ata B, Seli E.
    Semin Reprod Med, 33:436-48, 2015.

  • Oocyte cryopreservation as a preventive measure for age-related fertility loss.
    Cil AP, Turkgeldi L, Seli E.
    Semin Reprod Med, 33:429-35, 2015.

  • Ovarian ageing.
    Seli E.
    Semin Reprod Med, 33:375-6, 2015.

  • Human embryonic poly(A) binding protein (EPAB) alternative splicing is differentially regulated in human oocytes and embryos.
    Guzeloglu-Kayisli O, Lalioti MD, Babayev E, Torrealday S, Karakaya C, Seli E.
    Mol Hum Reprod, 20(1):59-65, 2014.

  • Epab is dispensable for Spermatogenesis and Male Fertility in Mice.
    Ozturk S*, Guzeloglu-Kayisli O*, Lowther K, Lalioti MD, Sakkas D, Seli E.
    Mol Reprod Dev, 81:390, 2014. *equal first authors.

  • Non-invasive prediction of embryonic sex in cattle by metabolomic analysis of in vitro culture medium with Fourier transfrom infrared spectroscopy.
    Muñoz M*, Uyar A*, Correia E, Díez C, Fernandez A, Caamaño JN, Trigal B, Carrocera S, Seli E, Gomez E.
    Metabolomics, 10:443-51, 2014. *equal first authors.

  • Metabolomic prediction of pregnancy viability in superovulated cattle embryos and recipients with fourier transform infrared spectroscopy.
    Muñoz M*, Uyar A*, Correia E, Ponsart C, Guyader-Joly C, Martínez-Bello D, Marquant-Le Guienne B, Fernandez-Gonzalez A, Díez C, Caamaño JN, Trigal B, Humblot P, Carrocera S, Martin D, Seli E, Gomez E.
    Biomed Res Int, 2014:608579, 2014. *equal first authors.

  • Prediction of pregnancy viability in bovine in vitro-produced embryos and recipient plasma with Fourier transform infrared spectroscopy.
    Muñoz M*, Uyar A*, Correia E, Díez C, Fernandez-Gonzalez A, Caamaño JN, Martínez-Bello D, Trigal B, Humblot P, Ponsart C, Guyader-Joly C, Carrocera S, Martin D, Le Guienne BM, Seli E, Gomez E.
    J Dairy Sci, 97:5497-507, 2014. *equal first authors.

  • Follicle stimulating hormone receptor (FSHR) alternative skipping of exon 2 or 3 affects ovarian response to FSH.
    Karakaya C, Guzeloglu-Kayisli O, Hobbs R, Gerasimova T, Uyar A, Erdem M, Oktem M, Erdem A, Gumuslu S, Ercan D, Sakkas D, Comizzoli P, Seli E, Lalioti MD.
    Mol Hum Reprod, 20:630-43 2014.

  • The expression of mRNA-binding protein TIA-1 is down-regulated in ectopic endometrium.
    Karalok HM, Aydin E, Saglam O, Torun A, Guzeloglu-Kayisli O, Lalioti MD, Kristansson H, Duke CMP, Choe G, Flannery C, Kallen CB, Seli E.
    J Clin Endocrinol Metab, 99:E2610-9, 2014.

  • Metabolomic assessment of embryo viability.
    Uyar A, Seli E.
    Semin Reprod Med, 32:141-52, 2014.

  • Non-invasive techniques: Embryo selection by transcriptomics, proteomics and metabolomics.
    Uyar A, Seli E.
    In: Montag M, Ed. A practical guide to select gametes and embryos. Springer/Humana Press, Berlin, German, pp 191-208, 2014.

  • The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders.
    Uyar A, Seli E.
    Curr Opin Obstet Gynecol, 26:210-21, 2014.

  • Metabolism of female reproduction: Regulatory mechanisms and clinical implications.
    Seli E, Babayev E, Collins SC, Nemeth G, Horvath TL.
    Mol Endo, 28:790-804, 2014.

  • mRNA-binding protein ZFP36 is expressed in atherosclerotic lesions and reduces inflammation in human aortic endothelial cells.
    Zhang H, Taylor WR, Joseph G, Sidell N, Seli E, Kallen CB.
    Arterioscl Thromb Vasc Biol, 33:1212-20 2013.

  • Characterization of the Gonadotropin Releasing Hormone Receptor (GnRHR) expression and activity in the Female Mouse Ovary.
    Torrealday S, Lalioti MD, Guzeloglu-Kayisli O, Seli E.
    Endocrinology, 154:3877-87, 2013.

  • Assisted reproduction in same sex couples.
    Greenfeld D, Seli E.
    In: M. Sauer ed. Principles of Oocyte and Embryo Donation. 2nd ed. Springer/Humana Press, Berlin, Germany, pp 289-301, 2013.

  • Cumulus and granulosa cell markers of oocyte and embryo quality.
    Uyar A, Torrealday S, Seli E.
    Fertil Steril, 99:979-997, 2013.

  • Current trends and progress in clinical applications of oocyte cryopreservation.
    Cil AP, Seli E.
    Curr Opin Obstet Gynecol, 25:247-54, 2013.

  • Current practices and regulations for embryo transfer worldwide: implications on ART outcome.
    Ata B, Seli E.
    In: D. Gardner, D. Sakkas, E. Seli, D. Wells eds. Emerging technologies for the assessment and diagnosis of gametes and embryos. Springer/Humana Press, Berlin, Germany, pp 1-7, 2013.

  • Regulation of gene expression in the oocyte and early embryo: implications for transcriptomic and proteomic embryo assessment.
    Kristiansson H, Seli E.
    In: D. Gardner, D. Sakkas, E. Seli, D. Wells eds. Emerging technologies for the assessment and diagnosis of gametes and embryos. Springer/Humana Press, Berlin, Germany, pp 163-172, 2013.

  • Metabolomic profiling of oocytes and embryos using spectroscopy: potential clinical use and pitfalls.
    Sakkas D, Seli E.
    In: D. Gardner, D. Sakkas, E. Seli, D. Wells eds. Emerging technologies for the assessment and diagnosis of gametes and embryos. Springer/Humana Press, Berlin, Germany, pp 275-280, 2013.

  • Genetics of the germ line formation.
    Ilbay O, Seli E.
    In: C. Simon, A. Pellicer and R. Reijo-Pera, eds. Stem Cells in Reproductive Medicine. 3nd ed. Cambridge, UK, Cambridge University Press, pp 1-14, 2013.

  • Natural Birth-induced UCP2 in Brain Development.
    Seli E, Horvath T.
    Rev Endocr Metab Disord, 14(4):347-50, 2013.

  • The mRNA-binding protein Zfp36 is up-regulated by b-adrenergic stimulation and represses IL-6 production in 3T3-L1 adipocytes.
    Brahma PK, Murray BS, Shu F, Sidell N, Seli E, Kallen CB.
    Obesity, 20:40-7, 2012.

  • The association between fertility clinic performance and patient volume: implications for patients’ response to physician performance.
    Gong D, Seli E.
    Fertil Steril, 98:55-62, 2012.

  • Dynamic phosphorylation of embryonic poly(A)-binding protein (ePAB) is required for Xenopus oocyte maturation.
    Friend JK, Brook ML, Bezirci FB, Sheets MD, Gray NR, Seli E.
    Biochem J, 445:93-100, 2012.

  • Epab and Pabpc1 are differentially expressed during male germ cell development.
    Ozturk S, Guzeloglu-Kayisli O, Demir N, Lalioti MD, Seli E.
    Reprod Sci,19:911-22, 2012.

  • Embryonic poly(A) binding protein (EPAB) is required for oocyte maturation and female fertility in mouse.
    Guzeloglu-Kayisli O, Lalioti MD, Sasson I, Aydiner F, Sakkas D, Seli E.
    Biochem J, 446:47-58, 2012.

  • Epidemiology of fertility preservation.
    Murk W, Seli E.
    In: A. Agarwal and E. Seli, eds. Fertility preservation: Emerging technologies and clinical applications. Springer/Humana Press, Berlin, Germany, pp 3-18, 2012.

  • Use of gonadotropin releasing hormone agonists in fertility preservation.
    Cakmak H, Seli E.
    In: A. Agarwal and E. Seli, eds. Fertility preservation: Emerging technologies and clinical applications. Springer/Humana Press, Berlin, Germany. pp 145-158, 2012.

  • Embryo assessment strategies and their validation for clinical use: a critical analysis of methodology.
    Uyar A, Seli E.
    Curr Opin Obstet Gynecol, 24:141-50, 2012.

  • Gay men choosing parenthood through assisted reproduction: medical and psychological considerations.
    Greenfeld D, Seli E.
    Fertil Steril, 95:225-9, 2011.

  • The mRNA-binding protein HuR is regulated in the menstrual cycle and repressed in ectopic endometrium.
    Karipcin S, Altun T, Kayisli UA, Guzel E, Kallen CB, Seli E.
    Reprod Sci, 18:145-55, 2011.

  • Receiver Operating Characteristic (ROC) analysis of Day 5 morphology grading and metabolomic Viability Scores on predicting implantation outcome.
    Seli E, Bruce C, Botros L, Henson M, Roos P, Judge K, Sakkas D and the Metabolomics Study Group.
    J Assist Reprod Genet, 28:137-44, 2011.

  • Assisted reproduction in a patient with Klippel-Trenaunay Syndrome: Management of thrombophilia and consumptive coagulopathy.
    Martin JR, Pels S, Paidas M, Seli E.
    J Assist Reprod Genet, 28:217-9, 2011.

  • The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis.
    Schober CS, Aydiner F, Booth CJ, Seli E, Reinke V.
    Mech Dev, 128:178-90, 2011.

  • Fertility preservation.
    Seli E.
    In: E. Seli, ed. Infertility; A. Arici series ed. Gynecology in Practice, Wiley-Blackwell, New Jersey, USA pp 164-174, 2011.

  • Epidemiology of fertility preservation.
    Murk W, Seli E.
    In Curr Opin Obstet Gynecol, 23:143-50, 2011.

  • Preterm deliveries that result from ART-associated multiple pregnancies in the United States: A cost analysis.
    Bromer JG, Ata B, Seli M, Lockwood CJ, Seli E.
    Curr Opin Obstet Gynecol, 23:168-73, 2011.

  • Metabolomic profiling as an adjunct to morphology for non-invasive embryo assessment in women undergoing single embryo transfer.
    Seli E, Vergouw CG, Kato O, Botros L, Roos P, Morita H, Lambalk CB, Yamashita N, Sakkas D.
    Fertil Steril, 94:535-42, 2010.

  • Identification and in vitro characterization of Follicle Stimulating Hormone (FSH) Receptor variants associated with abnormal ovarian response to FSH.
    Gerasimova T, Thanasoula M, Zattas D, Seli E, Sakkas D, Lalioti MD.
    J Clin Endocrinol Metab, 95:529-36, 2010.

  • The genetic and epigenetic contributions of sperm to early embryogenesis.
    Sakkas D, Lalioti MD, El-Fakahany HM, Seli E.
    In: D. Carrell and C.M. Peterson eds. Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice. Springer, New York, USA. pp 591-600, 2010.

  • Economics of assisted reproductive technologies.
    Ata B, Seli E.
    Curr Opin Obstet Gynecol, 22:183-8, 2010.

  • Perspectives on emerging biomarkers for non-invasive assessment of embryo viability in assisted reproduction.
    Aydiner F, Yetkin CE, Seli E.
    Curr Mol Med,10:206-15, 2010.

  • OMICS in assisted reproduction: possibilities and pitfalls.
    Seli E, Robert C, and Sirard M-A.
    Mol Hum Reprod, 16:513-30, 2010.

  • Third party reproduction and the aging couple.
    Luk J, Greenfeld D, Seli E.
    Maturitas, 66:389-96, 2010.

  • Ovulation Induction with clomiphene citrate.
    Seli E, Arici A.
    In: UpToDate, Rose, BD (Ed), UpToDate, Waltham, MA, 2010.

  • Should sperm parameters be considered in patient selection for SET?
    Sakkas D, El-Fakahany HM, Seli E.
    In: J. Gerris, D. Adamson, C. Rackowsky, P. De Suttter, eds. Single embryo transfer. Cambridge, UK: Cambridge University Press, pp 241-7, 2009.

  • Molecular biology of the gamete.
    Friend JK, Seli E.
    In: A. Pellicer and C. Simon, eds. Stem Cells in Reproductive Medicine. 2nd ed. London, UK: Taylor and Francis, pp 22-34, 2009.

  • Fertility preservation in cancer survivors.
    Bromer JG, Seli E.
    In: K. D. Miller, Ed. Medical and Psychosocial Care of the Cancer Survivor. Jones & Bartlett Publishers, Sudbury, MA, pp 413-26, 2009.

  • Non-Invasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: A prospective blinded pilot study.
    Scott R, Seli E, Miller K, Sakkas D, Scott K, Burns DH.
    Fertil Steril 90:77-83, 2008.

  • Alternative splicing of the mouse embryonic poly(A) binding protein (ePAB) RNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte.
    Seli E, Yaba A, Guzeloglu-Kayisli O, Lalioti MD.
    Mol Hum Reprod 14:393-8, 2008.

  • Non-invasive metabolomic profiling of embryo culture media using proton NMR correlates with reproductive potential of embryos in women undergoing in vitro fertilization.
    Seli E, Botros L, Sakkas D, Burns DH.
    Fertil Steril 90:2183-9, 2008.

  • Identification and characterization of human embryonic poly(A) binding protein (ePAB).
    Guzeloglu-Kayisli O, Pauli SA, Demir H, Lalioti MD, Sakkas D, Seli E.
    Mol Hum Reprod 14:581-8, 2008.

  • Metabolomics and its application for non-invasive embryo assessment in IVF.
    Botros L, Sakkas D, Seli E.
    Mol Hum Reprod 14:679-90, 2008.

  • Infertility.
    Rackow B, Seli E.
    In: A. Arici and E. Seli, eds. Non-invasive management of gynecologic disorders. London, UK: Informa healthcare pp 125-144, 2008.

  • Fertility preservation options for women with non-gynecologic cancers.
    Bianchi V, Johnson J, Seli E.
    In: A. Arici and E. Seli, eds. Non-invasive management of gynecologic disorders. London, UK: Taylor and Francis pp 145-158, 2008.

  • Assessment of embryo viability in ART: shortcomings of current approaches and the emerging role of metabolomics.
    Bromer J, Seli E.
    Curr Opin Obstet Gynecol, 20:234-41, 2008.

  • Metabolomic profiling of embryo culture media to predict IVF outcome.
    Bromer J, Sakkas D, Seli E.
    Expert Rev Obstet Gynecol. 3:441-447, 2008.

  • Evaluation of embryo quality by Metabolomics: A new strategy to aid single embryo transfer.
    Sakkas D, Morita H, Yamashita N, Kato LO, L. Botros L, Roos P, Seli E.
    J Mammal Ova Res. 25:26-31, 2008.

  • Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx.
    Daftary GS, Kayisli UA, Seli E, Bukulmez O, Arici A, Taylor HS.
    Fertil Steril 87:367-72, 2007.

  • Estrogen increases apoptosis in a murine atherosclerosis model.
    Seli E, Guzeloglu-Kayisli O, Kayisli UA, Kizilay G, Arici A.
    Fertil Steril 88:1190-6, 2007.

  • Non-Invasive metabolomic profiling of human embryo culture media using Raman and near infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization.
    Seli E, Sakkas D, Scott R, Kwok JS, Rosendahl S, Burns DH.
    Fertil Steril 88:1350-7, 2007.

  • Safety of sperm for use in ICSI.
    Sakkas D, Seli E, Bizzaro D, Manicardi GC, Jakab A, Huszar G.
    In: Diana Anderson and Martin H. Brinkworth eds. Male-Mediated Development Toxicology. Cambridge,UK: The Royal Society of Chemistry Publishing, pp. 85-93, 2007.

  • Molecular biology of the gamete.
    Vitiello D, Seli E.
    In: A. Pellicer and C. Simon, eds. Stem Cells in Reproductive Medicine. London, UK: Taylor and Francis pp 1-19, 2007.

  • Sperm DNA and embryo development.
    Sakkas D, Seli E.
    In: J. Cohen and K. Elder eds. Human preimplantation embryo selection. London, UK: Taylor and Francis pp 325-336, 2007.

  • Selection of viable embryos and gametes by rapid, non-invasive metabolomic profiling of oxidative stress biomarkers.
    Posilico JT and the Metabolomics Study Group for Reproductive Technologies.
    In: J. Cohen and K. Elder eds. Human preimplantation embryo selection. London, UK: Taylor and Francis pp 325-336, 2007.

  • Estradiol increases apoptosis in cultured human coronary artery endothelial cells (HCAEC) by up-regulating Fas expression.
    Seli E, Guzeloglu-Kayisli O, Cakmak H, Kayisli UA, Selam FB, Arici A.
    J Clin Endocrinol Metab 91(12):4995-5001, 2006.

  • Stem cells and fertility: what does the future hold?
    Kayisli UA, Seli E.
    Curr Opin Obstet Gynecol 18(3):338-43, 2006.

  • Metazoan oocyte and early embryo development program: a progression through translation regulatory cascades.
    *Vasudevan S, *Seli E, Steitz JA.
    Genes Dev 20:138-46, 2006. *These authors contributed equally to this work.

  • An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos.
    Seli E, Lalioti MD, Flaherty SM, Sakkas D, Terzi N, Steitz JA.
    Proc Natl Acad Sci USA 102:367-72, 2005.

  • Removal of hydrosalpinges increases endometrial leukemia inhibitory factor (LIF) expression at the time of implantation window.
    Seli E, Kayisli UA, Cakmak H, Bukulmez O, Bildirici I, Guzeloglu-Kayisli O, Arici A.
    Hum Reprod 20(11):3012-7, 2005.

  • The significance of sperm nuclear DNA strand breaks on reproductive outcome.
    Spano M, Seli E, Bizarro D, Manicardi GC, Sakkas D.
    Curr Opin Obstet Gynecol 17(3):255-60, 2005.

  • Fertility preservation options for female patients with malignancies.
    Seli E, Tangir J.
    Curr Opin Obstet Gynecol 17(3):299-308, 2005.

  • Spermatozoal nuclear determinants of reproductive outcome: implications on ART.
    Seli E, Sakkas D.
    Hum Reprod Update, 11:337-49, 2005.

  • The extent of nuclear DNA damage in ejaculated spermatozoa impacts on blastocyst development after IVF.
    Seli E, Gardner DK, Schoolcraft WB, Moffatt O, Sakkas D.

  • Fertil Steril 82:378-83, 2004.
    Treatment of PCOS with metformin and other insulin sensitizing agents.
    Seli E, Duleba A.
    Curr Diab Reports 4:69-75, 2004.

  • Immunology of endometriosis and immunotherapy.
    Seli E, Mahutte NG, Berkkanoglu M, Arici A.
    In: T. Tulandi and D. Redwine, eds. Endometriosis: advances and controversies. New York, NY: Marcel Dekker, Inc. pp 99-122, 2004.

  • Evidence based diagnosis and treatment of tubal factor infertility.
    Kodaman P, Arici A, Seli E.
    Curr Opin Obstet Gynecol 16: 221-9, 2004.

  • The presence of abnormal spermatozoa in the ejaculate: Did apoptosis fail?
    Sakkas D, Seli E, Manicardi GC, Nijs M, Ombelet W, Bizzaro D.
    Hum Fertil 7:99-103, 2004.

  • Pathogenesis of endometriosis.
    Seli E, Berkkanoglu M, Arici A.
    Obstet Gynecol Clin N Am 30(1): 41-61, 2003.

  • Endometriosis: Interaction of immune and endocrine systems.
    Seli E, Arici A.
    Semin Reprod Med 21(2): 135-44, 2003.

  • Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodeling during spermatogenesis.
    Sakkas D, Seli E, Bizzaro D, Tarozzi N, Manicardi GC.
    Reprod Biomed Online 7:35-9, 2003.

  • Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells.
    Seli E, Pehlivan T, Selam B, Mor G, Garcia-Velasco JA, Arici A.
    Fertil Steril 77: 542-7, 2002.

  • Estrogen suppresses vascular monocyte chemotactic protein-1 expression during early atherogenesis.
    Seli E, Kayisli UA, Selam B, Seli M, Arici A.
    Am J Obstet Gynecol 187:1544-9, 2002.

  • Modulation of the immune system by sex steroids.
    Seli E, Arici A.
    Inf Reprod Med Clin N Am 13:19-48, 2002.

  • Modulation of vascular immune function and atherosclerosis by reproductive hormones.
    Seli E.
    Inf Reprod Med Clin N Am 13: 233-248, 2002.

  • Optimizing ovulation induction in women with polycystic ovarian syndrome.
    Seli E, Duleba A.
    Curr Opin Obstet Gynecol 14 (3): 245-54, 2002.

  • The reproductive system from an immunological perspective.
    Seli E, Mahutte NG, Arici A.
    Immunol Allergy Clin N Am 22(3): 383-405, 2002.

  • Sex steroids and the immune system.
    Seli E, Arici A.
    Immunol Allergy Clin N Am 22(3): 407-433, 2002.

  • Proven and potential benefits of metformin in women with polycystic ovarian syndrome.
    Seli E, Duleba A.
    Hum Reprod 17(9): 2230-6, 2002.

  • Aminopeptidase N activity in human endometrium.
    Seli E, Senturk LM, Bahtiyar OM, Kayisli UA, Arici A.
    Fertil Steril 75:1172-6, 2001.

  • Estrogen inhibits monocyte chemotactic protein-1 production in human coronary artery smooth muscle cells: A mechanism for its anti-atherogenic effect.
    Seli E, Selam B, Mor G, Kayisli UA, Pehlivan T, Arici A.
    Menopause 8:296-301, 2001.

  • Cytokines in the peritoneal environment.
    Seli E, Arici A.
    In: J. Hill, ed. Cytokines in human reproduction. New York, NY: Wiley-Liss pp.239-258, 2000.

  • Growth-regulated gene a expression in human peritoneal environment with endometriosis.
    Oral E, Seli E, Bahtiyar MO, Olive DL, Arici A.
    Obstet Gynecol 88:1050-56, 1996.

  • Regulation of monocyte chemotactic protein-1 expression in human endometrial stromal cells by estrogen and progesterone.
    Arici A, Senturk LM, Seli E, Bahtiyar MO, Kim G.
    Biol Reprod 61:85-90, 1999.

  • Regulation of monocyte chemotactic protein-1 expression in human endometrial cells by integrin-dependent cell adhesion.
    Garcia-Velasco JA, Seli E, Arici A.
    Biol Reprod 61:548-52, 1999.

  • Monocyte chemotactic protein-1 expression in human corpus luteum.
    Senturk LM, Seli E, Gutierrez LS, Mor G, Zeyneloglu HB, Arici A.
    Mol Hum Reprod 5:697-702, 1999.

  • Basic fibroblast growth factor: peritoneal and follicular fluid levels and its effect on the early embryonic development.
    Seli E, Zeyneloglu HB, Senturk ML, Bahtiyar OM, Olive DL, Arici A.
    Fertil Steril 69:1145-8, 1998.

  • Interleukin-8 induces proliferation of endometrial stromal cells: A potential autocrine growth factor.
    Arici A, Seli E, Zeyneloglu HB, Senturk LM, Oral E, Olive DL.
    J Clin Endocrinol Metab 83:1201-5, 1998.

  • Interleukin-8 in the human endometrium.
    Arici A, Seli E, Senturk LM, Gutierrez LS, Oral E, Taylor HS.
    J Clin Endocrinol Metab 83:1783-7, 1998.

  • The peritoneal fluid levels of Interleukin-12 in women with endometriosis.
    Zeyneloglu HB, Senturk ML, Seli E, Bahtiyar OM, Olive DL, Arici A.
    American J Reprod Immunol 39:152-6, 1998.

  • The effect of monocyte chemotactic protein-1 in intraperitoneal adhesion formation in a mice model.
    Zeyneloglu HB, Seli E, Senturk LM, Gutierrez LS, Olive DL, Arici A.
    Am J Obstet Gynecol 179:438-43, 1998.

  • The role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation.
    Zeyneloglu HB, Senturk LM, Seli E, Oral E, Olive DL, Arici A.
    Hum Reprod 13:1194-9, 1998.

  • Midtrimester urine human chorionic gonadotropin b-subunit core fragment levels and the subsequent development of preeclampsia.
    Bahado-Singh RO, Oz U, Isozaki T, Seli E, Kovanci E, Hsu CD, Cole L.
    Am J Obstet Gynecol 179:738-41, 1998.

  • Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells.
    Bahtiyar OM, Seli E, Oral E, Senturk LM, Zreik T, Arici A.
    Hum Reprod 13:3492-5, 1998.

  • Leukemia inhibitory factor expression in human follicular fluid and ovarian cells.
    Arici A, Oral E, Bahtiyar MO, Engin O, Seli E, Jones EE.
    Hum Reprod 12:1233-9, 1997.

  • Growth-regulated a expression in human preovulatory follicles and ovarian cells.
    Oral E, Seli E, Bahtiyar MO, Jones EE, Arici A.
    Am J Reprod Immunol 38:19-25, 1997.


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