José Bellver, M.D.

Gynecologist at IVI Valencia and Clinical Researcher at the IVI Foundation

IVI Valencia

José Bellver, M.D.

Biography

Dr. José Bellver is an attending gynecologist at IVI Valencia, clinical researcher at the IVI Foundation, Assistant Professor in the Department of Pediatrics, Obstetrics and Gynecology, University of Valencia School of Medicine, and Associate Professor accredited by ANECA (National Agency for the Accreditation and Evaluation of Quality of Spanish Universities).

He obtained his Bachelor’s degree in Medicine & Surgery with a Special distinction (“Premio Extraordinario de Licenciatura”) at the University of Valencia in 1993. He completed his residency in Obstetrics and Gynecology at the Hospital Universitario La Fe, Valencia, from January 1995 to December 1998, and was visiting fellow in the High Risk Pregnancy Unit of the John Radcliffe Maternity Hospital, Oxford, UK, in 1998. He is specialist in Obstetrics & Gynaecology from January 1999. He obtained the Level III of ultrasonography in Obstetrics & Gynaecology by the Sociedad Española de Obstetricia y Ginecología (SEGO) in 1998, being re-accredited in 2015, and the European Certificate of Gynaecological Endoscopic Surgery in Clermnont Ferrand, during 1998-1999. He initially worked as specialist in Human Reproduction and Obstetrics in Instituto Bernabeu, Alicante, for a year, and then started his clinical and research activities in the Instituto Valenciano de Infertilidad, Valencia, from February 2000 until now. He received Doctor in Medicine and Surgery (MD) degree with Cum Laude (2001) and a Special distinction (“Premio Extraordinario de Doctorado”, 2004) by the University of Valencia. He obtained the Certificate of Competence in Prenatal Diagnosis (”Ultrasound examination at 11-13+6 weeks”) by the Fetal Medicine Foundation, King´s College, London, and a Master’s in Advanced Gynaecological Endoscopic Surgery, in Valencia, 2004-2005.

He has published 208 original articles or book chapters, including 77 papers in international journals with impact factor. He is editor/co-editor of 8 books on human reproduction. He has been invited to 80 international and national lectures and has participated in 155 oral/poster presentations in international and national congresses. Dr. Bellver is Member of the Editorial Board of “Cuadernos de Medicina Reproductiva”, “Open Autoimmunity Journal”, “Open Obesity Journal” and “Case Reports in Obstetrics and Gynecology”. He has been past Member of the “Grupo Latinoamericano de Interés en Reproducción Humana” and the “Global Fertility Academy”. Dr. Bellver is Assessor of “McMaster Online Rating of Evidence (MORE) System”, Mc Master University, Ontario, Canada, and reviewer of 22 international journals about human reproduction.

Dr. Bellver has been director or co-director of 6 doctoral thesis, is Member of the Research Committee of the Instituto Valenciano de Infertilidad and Board member of the Ethical Committee of the Instituto Valenciano de Infertilidad. He is now Coordinator of the Group of Interest in Reproductive Endocrinology and Member of the Task Force on Reproductive Failure of the Spanish Fertility Society (SEF).


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Education and Training

BS University of Valencia (1993)
Residency University Hospital La Fe, University of Valencia (1998)
MD University of Valencia (2001)
Training Instituto Valenciano de Infertilidad, University of Valencia

Honors and recognition

Human Reproduction Top Reviewer 2013 & 2015
Generalitat Valenciana Special Prize in the field of scientific research in biomedicine and health sciences 2010
Doctor in Medicine & Surgery (MD) with Special distinction 2004
Licentiate in Medicine & Surgery with a Special distinction 1993

Publications


  • Does an increased body mass index affect endometrial gene expression patterns in infertile patients? A functional genomics analysis.
    Comstock IA, Diaz-Gimeno P, Cabanillas S, Bellver J, Sebastian-Leon P, Shah M, Schutt A, Valdes CT, Ruiz-Alonso M, Valbuena D, Simon C, Lathi RB.
    Fertil Steril, 107:740-748.e2, 2017.



  • Response: in reference to 'Strategies to manage refractory endometrium: state of the art 2016'.
    Garcia-Velasco JA, Acevedo B, Alvarez C, Alvarez M, Bellver J, Fontes J, Landeras J, Manau D, Martinez F, Muñoz E, Robles A, Rodriguez-Tabernero L.
    Reprod Biomed Online, 33:605, 2016.

  • Strategies to manage refractory endometrium: state of the art in 2016.
    Garcia-Velasco JA, Acevedo B, Alvarez C, Alvarez M, Bellver J, Fontes J, Landeras J, Manau D, Martinez F, Muñoz E, Robles A, Rodriguez-Tabernero L.
    Reprod Biomed Online, 32: 474-89, 2016.

  • The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies.
    Martínez-Varea A, Pellicer B, Serra V, Hervás-Marín D, Martínez-Romero A, Bellver J, Perales-Marín A, Pellicer A.
    J Immunol Res, 2015:128616, 2015.

  • Doubtful association between progesterone therapy and fetal nuchal translucency.
    Serra V, Bellver J, Garrido N.
    Am J Obstet Gynecol, 213:437, 2015.

  • Day-3 embryo metabolomics in the spent culture media is altered in obese women undergoing in vitro fertilization.
    Bellver J, De Los Santos MJ, Alamá P, Castelló D, Privitera L, Galliano D, Labarta E, Vidal C, Pellicer A, Domínguez F.
    Fertil Steril,103:1407-15.e1, 2015.

  • ART and uterine pathology: how relevant is the maternal side for implantation?
    Galliano D, Bellver J, Díaz-García C, Simón C, Pellicer A.
    Hum Reprod Update, 21:13-38, 2015.


  • Is ovarian reserve related to blood type?
    Bellver J.
    Fertil Steril,102:1563-4, 2014.

  • Reply: Endometrial scratching for women with repeated implantation failure.
    Simón C, Bosch E, Bellver J.
    Hum Reprod, 29: 2856-7, 2014.

  • Clinical validation of embryo culture and selection by morphokinetic analysis: a randomized, controlled trial of the EmbryoScope.
    Rubio I, Galán A, Larreategui Z, Ayerdi F, Bellver J, Herrero J, Meseguer M.
    Fertil Steril, 102:1287-1294, 2014.

  • Deciphering the proteomic signature of human endometrial receptivity.
    Garrido-Gómez T, Quiñonero A, Antúnez O, Díaz-Gimeno P, Bellver J, Simón C, Domínguez F.
    Hum Reprod, 29:1957-67, 2014.

  • Scratching beneath 'The Scratching Case': systematic reviews and meta-analyses, the back door for evidence-based medicine.
    Simón C, Bellver J.
    Hum Reprod, 29:1618-21, 2014.

  • Live birth after embryo transfer in an unresponsive thin endometrium.
    Cruz F, Bellver J.
    Gynecol Endocrinol, 30:481-4, 2014.

  • Additive effect of factors related to assisted conception on the reduction of maternal serum pregnancy-associated plasma protein A concentrations and the increased false-positive rates in first-trimester Down syndrome screening.
    Bellver J, Casanova C, Garrido N, Lara C, Remohí J, Pellicer A, Serra V.
    Fertil Steril,100:1314-20, 2013.

  • Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors.
    Bellver J, Pellicer A, García-Velasco JA, Ballesteros A, Remohí J, Meseguer M.
    Fertil Steril, 100:1050-8, 2013.

  • GnRH analogues in the prevention of ovarian hyperstimulation syndrome.
    Alama P, Bellver J, Vidal C, Giles J.
    Int J Endocrinol Metab, 11:107-16, 2013.

  • Female obesity: short- and long-term consequences on the offspring.
    Galliano D, Bellver J.
    Gynecol Endocrinol, 29:626-31, 2013.

  • Obesity and poor reproductive outcome: female and male body weight matter.
    Bellver J.
    Fertil Steril, 99:1558-9, 2013.

  • Similar morphokinetic patterns in embryos derived from obese and normoweight infertile women: a time-lapse study.
    Bellver J, Mifsud A, Grau N, Privitera L, Meseguer M.
    Hum Reprod, 28:794-800, 2013.

  • Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials.
    Rubio C, Bellver J, Rodrigo L, Bosch E, Mercader A, Vidal C, De los Santos MJ, Giles J, Labarta E, Domingo J, Crespo J, Remohí J, Pellicer A, Simón C.
    Fertil Steril, 99:1400-7, 2013.

  • Limited implantation success of direct-cleaved human zygotes: a time-lapse study.
    Rubio I, Kuhlmann R, Agerholm I, Kirk J, Herrero J, Escribá MJ, Bellver J, Meseguer M.
    Fertil Steril, 98:1458-63, 2012.

  • Increased doses of vaginal progesterone for the prevention of preterm birth in twin pregnancies: a randomised controlled double-blind multicentre trial.
    Serra V, Perales A, Meseguer J, Parrilla JJ, Lara C, Bellver J, Grifol R, Alcover I, Sala M, Martínez-Escoriza JC, Pellicer A.
    BJOG, 120:50-7, 2013.

  • Cumulative newborn rates increase with the total number of transferred embryos according to an analysis of 15,792 ovum donation cycles.
    Garrido N, Bellver J, Remohí J, Alamá P, Pellicer A.
    Fertil Steril, 98:341-6.e1-2, 2012.

  • Hepatitis B virus in human oocytes and embryos.
    Garrido N, Bellver J, Rubio C, Pellicer A.
    Hum Reprod, 27:1227-8, 2012.

  • Viral screening of spent culture media and liquid nitrogen samples of oocytes and embryos from hepatitis B, hepatitis C, and human immunodeficiency virus chronically infected women undergoing in vitro fertilization cycles.
    Cobo A, Bellver J, de los Santos MJ, Remohí J.
    Fertil Steril, 97:74-8, 2012.

  • Female overweight is not associated with a higher embryo euploidy rate in first trimester miscarriages karyotyped by hysteroembryoscopy.
    Bellver J, Cruz F, Martínez MC, Ferro J, Ramírez JF, Pellicer A, Garrido N.
    Fertil Steril, 96:931-3, 2011.

  • Cumulative live-birth rates per total number of embryos needed to reach newborn in consecutive in vitro fertilization (IVF) cycles: a new approach to measuring the likelihood of IVF success.
    Garrido N, Bellver J, Remohí J, Simón C, Pellicer A.
    Fertil Steril, 96:40-6, 2011.

  • Endometrial gene expression in the window of implantation is altered in obese women especially in association with polycystic ovary syndrome.
    Bellver J, Martínez-Conejero JA, Labarta E, Alamá P, Melo MA, Remohí J, Pellicer A, Horcajadas JA.
    Fertil Steril, 95:2335-41, 2011.

  • Y chromosome microdeletions, sperm DNA fragmentation and sperm oxidative stress as causes of recurrent spontaneous abortion of unknown etiology.
    Bellver J, Meseguer M, Muriel L, García-Herrero S, Barreto MA, Garda AL, Remohí J, Pellicer A, Garrido N.
    Hum Reprod, 25:1713-21, 2010.

  • A prospective, randomized, controlled trial comparing three different gonadotropin regimens in oocyte donors: ovarian response, in vitro fertilization outcome, and analysis of cost minimization.
    Melo M, Bellver J, Garrido N, Meseguer M, Pellicer A, Remohí J.
    Fertil Steril, 94:958-64, 2010.

  • Blood group and ovarian hyperstimulation syndrome.
    Bellver J, Ferrando M, Garrido N, Pellicer A.
    Fertil Steril, 93:270-1, 2010.

  • GnRH agonist administration at the time of implantation does not improve pregnancy outcome in intrauterine insemination cycles: a randomized controlled trial.
    Bellver J, Labarta E, Bosch E, Melo MA, Vidal C, Remohí J, Pellicer A.
    Fertil Steril, 94:1065-71, 2010.

  • Female obesity impairs in vitro fertilization outcome without affecting embryo quality.
    Bellver J, Ayllón Y, Ferrando M, Melo M, Goyri E, Pellicer A, Remohí J, Meseguer M.
    Fertil Steril, 93:447-54, 2010.

  • GnRH agonist versus recombinant HCG in an oocyte donation programme: a randomized, prospective, controlled, assessor-blind study.
    Melo M, Busso CE, Bellver J, Alama P, Garrido N, Meseguer M, Pellicer A, Remohí J.
    Reprod Biomed Online, 19:486-92, 2009.

  • Ovarian stimulation for ovulation induction and in vitro fertilization in patients with systemic lupus erythematosus and antiphospholipid syndrome.
    Bellver J, Pellicer A.
    Fertil Steril, 92:1803-10, 2009.

  • Computerized analysis of normal fetal heart rate pattern throughout gestation.
    Serra V, Bellver J, Moulden M, Redman CW.
    Ultrasound Obstet Gynecol, 34:74-9, 2009.

  • Antral follicle count (AFC) can be used in the prediction of ovarian response but cannot predict the oocyte/embryo quality or the in vitro fertilization outcome in an egg donation program.
    Melo MA, Garrido N, Alvarez C, Bellver J, Meseguer M, Pellicer A, Remohí J.
    Fertil Steril, 91:148-56, 2009.

  • Influence of paternal age on assisted reproduction outcome.
    Bellver J, Garrido N, Remohí J, Pellicer A, Meseguer M.
    Reprod Biomed Online, 17:595-604, 2008.

  • The value of the short-term fetal heart rate variation for timing the delivery of growth-retarded fetuses.
    Serra V, Moulden M, Bellver J, Redman CW.
    BJOG, 115:1101-7, 2008.

  • New options in assisted reproduction technology: the Cryotop method of oocyte vitrification.
    Cobo A, Bellver J, Domingo J, Pérez S, Crespo J, Pellicer A, Remohí J.
    Reprod Biomed Online, 17:68-72, 2008.

  • The role of thrombophilia and thyroid autoimmunity in unexplained infertility, implantation failure and recurrent spontaneous abortion.
    Bellver J, Soares SR, Alvarez C, Muñoz E, Ramírez A, Rubio C, Serra V, Remohí J, Pellicer A.
    Hum Reprod, 23:278-84, 2008.

  • Human immunodeficiency type-1 virus (HIV-1) infection in serodiscordant couples (SDCs) does not have an impact on embryo quality or intracytoplasmic sperm injection (ICSI) outcome.
    Melo MA, Meseguer M, Bellver J, Remohí J, Pellicer A, Garrido N.
    Fertil Steril, 89:141-50, 2008.

  • Implantation is apparently unaffected by the dopamine agonist Cabergoline when administered to prevent ovarian hyperstimulation syndrome in women undergoing assisted reproduction treatment: a pilot study.
    Alvarez C, Alonso-Muriel I, García G, Crespo J, Bellver J, Simón C, Pellicer A.
    Hum Reprod, 22:3210-4, 2007.

  • Clinical factors associated with the outcome of oocyte donation.
    Vernaeve V, Reis Soares S, Budak E, Bellver J, Remohi J, Pellicer A.
    Gynecol Obstet Fertil, 35:1015-23, 2007.

  • Obesity and poor reproductive outcome: the potential role of the endometrium.
    Bellver J, Melo MA, Bosch E, Serra V, Remohí J, Pellicer A.
    Fertil Steril, 88:446-51, 2007.

  • Early pregnancy loss in women stimulated with gonadotropin-releasing hormone antagonist protocols according to oral contraceptive pill pretreatment.
    Bellver J, Albert C, Labarta E, Pellicer A.
    Fertil Steril, 87:1098-101, 2007.

  • Delaying the initiation of progesterone supplementation until the day of fertilization does not compromise cycle outcome in patients receiving donated oocytes: a randomized study.
    Escribá MJ, Bellver J, Bosch E, Sánchez M, Pellicer A, Remohí J.
    Fertil Steril, 86:92-7, 2006.

  • Obesity and assisted reproductive technology outcomes.
    Bellver J, Busso C, Pellicer A, Remohí J, Simón C.
    Reprod Biomed Online , 12:562-8, 2006.

  • Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system.
    Budak E, Fernández Sánchez M, Bellver J, Cerveró A, Simón C, Pellicer A.
    Fertil Steril, 85:1563-81, 2006.

  • Examination of the fetal brain by transabdominal three-dimensional ultrasound: potential for routine neurosonographic studies.
    Correa FF, Lara C, Bellver J, Remohí J, Pellicer A, Serra V.
    Ultrasound Obstet Gynecol, 27: 503-8, 2006.

  • Doubtful association between TAR syndrome and increased nuchal translucency in the first trimester of pregnancy.
    Bellver J, Lara C, Correa FF, Serra V.
    Prenat Diagn, 26:382-3, 2006.

  • Potential pitfalls in fetal neurosonography.
    Correa FF, Lara C, Bellver J, Remohí J, Pellicer A, Serra V.
    Prenat Diagn, 26:52-6, 2006.

  • Evidence-based medicine is gaining momentum.
    Bellver J, Bosch E, Remohí J, Pellicer A.
    Fertil Steril, 84:1555-6, 2005.

  • Similar endometrial development in oocyte donors treated with either high- or standard-dose GnRH antagonist compared to treatment with a GnRH agonist or in natural cycles.
    Simon C, Oberyé J, Bellver J, Vidal C, Bosch E, Horcajadas JA, Murphy C, Adams S, Riesewijk A, Mannaerts B, Pellicer A.
    Hum Reprod, 20:3318-27, 2005.

  • First trimester biochemical screening for Down's syndrome in singleton pregnancies conceived by assisted reproduction.
    Bellver J, Lara C, Soares SR, Ramírez A, Pellicer A, Remohí J, Serra V.
    Hum Reprod, 20:2623-7, 2005.

  • The singleton, term gestation, and live birth rate per cycle initiated: a 1-year experience in in vitro fertilization cycles with native and donated oocytes.
    Bellver J, Albert C, Soares SR, Alvarez C, Pellicer A.
    Fertil Steril, 83:1404-9, 2005.

  • First-trimester diagnosis of thrombocytopenia-absent radius (TAR) syndrome in a triplet pregnancy.
    Bellver J, Lara C, Pérez-Aytés A, Pellicer A, Remohí J, Serra V.
    Prenat Diagn, 25:332-4, 2005.

  • Can antenatal steroids be considered a fetal "stress" test in cases of severe placental insufficiency?
    Serra V, Bellver J, Redman CW.
    Am J Obstet Gynecol, 191:1839, 2004.

  • An anatomical fetal brain structure and a normal variant mimicking anomalies on routine neurosonographic imaging: report of two cases.
    Correa FF, Lara C, Bellver J, Remohí J, Pellicer A, Serra V.
    Ultrasound Obstet Gynecol; 24:672-4, 2004.

  • Report of the results of a 2 year programme of sperm wash and ICSI treatment for human immunodeficiency virus and hepatitis C virus serodiscordant couples.
    Garrido N, Meseguer M, Bellver J, Remohí J, Simón C, Pellicer A.
    Hum Reprod, 19:2581-6, 2004.

  • Reproductive issues for persons with HIV.
    Garrido N, Meseguer M, Bellver J.
    Am J Obstet Gynecol; 190:1489, 2004.

  • BMI--the fragility of fertility.
    Bellver J, Bosch E, Pellicer A.
    Fertil Steril, 81:727, 2004.

  • Can antepartum computerized cardiotocography predict the evolution of intrapartum acid-base status in normal fetuses?
    Bellver J, Perales A, Maiques V, Serra V.
    Acta Obstet Gynecol Scand, 83:267-71, 2004.

  • Impact of obesity on spontaneous abortion.
    Bellver J, Pellicer A.
    Am J Obstet Gynecol, 190:293-4, 2004.

  • First-trimester reversed end-diastolic flow in the umbilical artery is not always an ominous sign.
    Bellver J, Lara C, Rossal LP, Remohí J, Pellicer A, Serra V.
    Ultrasound Obstet Gynecol, 22:652-5, 2003.

  • Intravenous albumin does not prevent moderate-severe ovarian hyperstimulation syndrome in high-risk IVF patients: a randomized controlled study.
    Bellver J, Muñoz EA, Ballesteros A, Soares SR, Bosch E, Simón C, Pellicer A, Remohí
    J. Hum Reprod; 18:2283-8, 2003.

  • Bilateral partial oophorectomy in the management of severe ovarian hyperstimulation syndrome (OHSS): ovarian mutilating surgery is not an option in the management of severe OHSS.
    Bellver J, Escudero E, Pellicer A.
    Hum Reprod, 18:1363-7, 2003.

  • Obesity and the risk of spontaneous abortion after oocyte donation.
    Bellver J, Rossal LP, Bosch E, Zúñiga A, Corona JT, Meléndez F, Gómez E, Simón C, Remohí J, Pellicer A.
    Fertil Steril, 79:1136-40, 2003.

  • In vitro fertilization with intracytoplasmic sperm injection for human immunodeficiency virus-1 serodiscordant couples.
    Garrido N, Meseguer M, Bellver J.
    Am J Obstet Gynecol, 187:1121, 2002.

  • Estrogen levels and thrombophilia--an intervening variable or a confounder?
    Bellver J, Simón C, Pellicer A.
    Fertil Steril, 78:887-8, 2002.

  • Silver-Russell syndrome associated to Mayer-Rokitansky-Kuster-Hauser syndrome, diabetes and hirsutism.
    Bellver-Pradas J, Cervera-Sánchez J, Boldó-Roda A, Martín-Cortés A, Ferreres-Gómez L, Serra-Serra V, Romeu-Sarrió A.
    Arch Gynecol Obstet, 265:155-7, 2001.

  • Obstetric significance of anti-Jr(a) antibody.
    Bellver-Pradas J, Arriaga-Chafer F, Perales-Marín A, Maiques-Montesinos V, Serra-Serra V.
    Am J Obstet Gynecol, 184:75-6, 2001.

  • Effects of prandial glycemic changes on objective fetal heart rate parameters.
    Serra-Serra V, Camara R, Sarrión P, Jareño M, Cervera J, Bellver J, Perales A.
    Acta Obstet Gynecol Scand, 79:953-7, 2001.

  • Post-cesarean section morbidity in HIV-positive women.
    Maiques-Montesinos V, Cervera-Sanchez J, Bellver-Pradas J, Abad-Carrascosa A, Serra-Serra V.
    Acta Obstet Gynecol Scand, 78:789-92, 1999.

  • Myoadenylate deaminase deficiency myopathy in pregnancy.
    Bellver J, Cervera J, Boldó A, Abad A, Perales A, Garcia Domenech R, Román JA, Monleón J.
    Arch Gynecol Obstet, 259:157-9, 1997.


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