José Serna, M.D., Ph.D.

Biography

Dr. José Serna is the Medical Director of IVI Zaragoza where he combines his management duties with his medical practice. He obtained his M.D. degree in 1993 at the Hospital Militar Universitario del Ejercito del Aire, Universidad Complutense de Madrid. During his last year at school, he pursued his enthusiasm in biology and basic research and was enrolled in the Growth Factor Laboratory at the Developmental Biology Department at Centro de Investigaciones Biológicas (CSIC) in Madrid. After competing medical school, he gained a predoctoral fellowship to investigate the role of insulin family of growth factors in embryo development. He then obtained his Ph.D. in Molecular Biology and Biochemistry and moved forward in basic research obtaining a Marie Curie Post-doctoral Fellowship fulfilling simultaneously clinical training and basic research in the Pediatrics Department at St. Bartholomew Hospital in London.

In 2000, he started his residency training in Obstetrics and Gynecology in Fundación Jiménez Díaz with a special interest in Gynecological Endocrinology and Reproduction. He also worked as an Assistant Professor at Universidad Autónoma de Madrid Medical School and Nursing School. After his specialization, he joined IVI group as an attending physician at IVI Madrid for four years. Then he moved to IVI Bilbao as Chief Medical Officer and afterwards, in 2009, to IVI Zaragoza. He has been certified with the ESHRE Certification for Reproductive Endoscopic Surgeons.

Dr. Serna teaches in several University Degree Programs and collaborates actively as lecturer and instructor in Experimental Surgery at Instituto Aragonés de Ciencias de la Salud (IACS). He is the director of several Master’s Theses in the field of gynecology and embryology. He acts as advisor in translational research in the Reproduction Medicine Group of the IACS. He belongs to the IVI Foundation where he conducts several research projects and he has received public and private funding for his research.

Dr. Serna had numerous presentations in national and international meetings and has written and contributed to more than 100 publications, book chapters and conference proceedings. He is an Ad Hoc reviewer for leading reproductive journals including Fertility and Sterility, Human Reproduction, Human Fertility and Reproductive Biomedicine Online.

Education and Training

MD	Universidad Complutense de Madrid (1993)
Fellowship	Centro de Investigaciones Biológicas. Consejo Superior de Investigaciones Científicas (CSIC) Madrid. (1998)
PhD	Department of Biochemistry and Molecular Biology. Universidad Complutense de Madrid (1998)
Postdoctoral	Dpt. Pediatrics. Saint Bartholomew Hospital. London (1999)
SUD	Reproductive Medicine. Universidad Nacional de Educación a Distancia (2003)
Residency	Fundación Jiménez Díaz. Madrid (2006)

Publications

Pancreatic autoimmunity: An unknown etiology on patients with assisted reproductive techniques (ART)-recurrent reproductive failure
Alecsandru D, Barrio A, Andia V, Cruz E, Aparicio P, Serna J, Cruz M, Pellicer A, Garcia-Velasco J A,

PLoS One. 2018 doi: 10.1371/journal.pone.0203446

Pros and cons of implementing a carrier genetic test in an infertility practice
Gil-Arribas E, Herrer R, Serna J,

Curr Opin Obstet Gynecol. 2016 doi:

Effects of adipocyte-secreted factors on decidualized endometrial cells: modulation of endometrial receptivity in vitro
Gamundi-Segura S, Serna J, Oehninger S, Horcajadas J A, Arbones-Mainar J M,

J Physiol Biochem. Sep. 2015 doi: 10.1007/s13105-015-0393-0

An engaging example of translational medicine: the Wnt/beta-catenin cellular pathway and pharmacological research in fibroid treatment
Serna J,

Fertil Steril. May. 2014 doi: 10.1016/j.fertnstert.2014.02.010

Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature.
Fauser B, Devroey P, Diedrich K, Balaban B, Bonduelle M, de Waal HAD, Estella C, Ezcurra D, Geraedts JP, Howles CM, Lerner-Geva L, Serna J, Wells D, Ezcurra D,

RBM Online. 2014 doi:

Manejo expectante de las gestaciones de localización desconocida después de una técnica de reproducción asistida: Manejo clínico, pronóstico y complicaciones asociadas.
Puente J M, Serna J, Martinez M, Muñoz J, Pacheco A, Garcia-Velasco J A,

Reproducción. 2012 doi:

Estradiol supplementation during the luteal phase of IVF-ICSI patients: a randomized, controlled trial
Serna J, Cholquevilque J L, Cela V, Martinez-Salazar J, Requena A, Garcia-Velasco J A,

Fertil Steril. Dec. 2008 doi: 10.1016/j.fertnstert.2007.10.021

Systemic methotrexate to treat ectopic pregnancy does not affect ovarian reserve
Oriol B, Barrio A, Pacheco A, Serna J, Zuzuarregui J L, Garcia-Velasco J A,

Fertil Steril. Nov. 2008 doi: 10.1016/j.fertnstert.2007.08.032

Effect of repeated assisted reproduction techniques on the ovarian response
Serna J, Garcia-Velasco J A,

Curr Opin Obstet Gynecol. Jun. 2005 doi: 10.1097/01.gco.0000169098.90966.50

New trends in IVF. Is there any evidence?
Serna J, Pellicer A,

Controversies in Obstetrics Gynecology and Infertility. 2005 doi:

Unprocessed proinsulin promotes cell survival during neurulation in the chick embryo.
Hernandez-Sanchez C, Rubio E, Serna J, de la Rosa EJ, de Pablo F,

Diabetes. 2002 doi:

In vivo regulation of cell death by embryonic (pro)insulin and the insulin receptor during early retinal neurogenesi
Diaz B, Serna J, De Pablo F, De la Rosa EJ,

Development. 2000 doi:

Flow cytometric analysis of whole organs and embryos.
Serna J, Pimentel B, De la Rosa EJ,

Curr Top Dev Biol. 1998 doi:

Modulation of the chaperone heat shock cognate 70 by embryonic (pro)insulin correlates with prevention of apoptosis.
De la Rosa EJ, Vega-Nunez E, Morales AV, Serna J, Rubio E, De Pablo F,

Proc Natl Acad Sci USA. 1998 doi:

Proinsulin and insulin-like growth factor I complementary expression and roles in early development.
Alarcon C, Morales AV, Pimentel B, Serna J, De Pablo F,

Comp Biochem Physiol B Biochem Mol Biol. 1998 doi:

Synthesis and differentially regulated processing of proinsulin in developing chick pancreas, liver and neuroretina.
Alarcon C, Serna J, Perez-Villamil B, De Pablo F,

FEBS Lett. 1998 doi:

Complementary roles of the insulin family of factors and receptors in early development and neurogenesis.
De Pablo F, Alarcon C, Diaz B, Garcia-De Lacoba M, Lopez-Carranza A, Morales AV, Pimentel B, Serna J, De la Rosa EJ, Serna J,

Int J Dev Biol. 1996 doi:

Differential and tissue-specific regulation of (pro)insulin and insulin-like growth factor-I mRNAs and levels of thyroid hormones in growth-retarded embryos.
Serna J, Gonzalez-Guerrero PR, Scanes CG, Prati M, Morreale G, De Pablo F,

Growth Regul. 1996 doi:

Et al. IGF-I and the IGF-I receptor in development of nonmammalian vertebrates.
De Pablo F, Perez-Villamil B, Serna J, Gonzalez-Guerrero PR, Lopez-Carranza A, De la Rosa EJ,

Mol Reprod Dev. 1993 doi:

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