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Fertility Researchers

OUR INVESTIGATORS

María Cruz, Ph.D.

Clinical Embryologist at IVI Madrid

IVI Madrid

Biography

Dr. María Cruz, is a clinical embryologist at IVI Madrid and a faculty for the Master’s Degree in Biology and Technology Applied to Assisted Human Reproduction at the European University of Madrid. She obtained her B.S.c in in Biological Sciences at the Complutense University of Madrid and received her Ph.D. from University of Valencia. Dra. Cruz also obtained a Master’s Degree in Biotechnology of Assisted Human Reproduction and a course of Research Methodology applied to Design and Statistics in Health sciences from the Autonoma University of Barcelona. Her research interests include Endocrinology, time-lapse analysis and genetic polymorphisms.

Education and Training

B.S.c in in Biological Sciences	Complutense University of Madrid
Ph. D	University of Valencia
Master’s Degree in Biotechnology of Assisted Human Reproduction Autonoma	University of Barcelona

Publications

The type of SARS-CoV-2 vaccine does not affect ovarian function in assisted reproduction cycle.
Requena A, Vergara V, González-Ravina C, Ruiz ME, Cruz M

Fertil Steril. 2022 Dec 17:S0015-0282(22)02109-4. doi: 10.1016/j.fertnstert.2022.12.022. Online ahead of print.. 2022 doi:

Impact of parental chromosomal polymorphisms on the incidence of congenital anomalies and perinatal complications in a cohort of newborns conceived after ICSI + PGT-A.
Rodriguez F, Cruz M, Requena A

Reprod Biol Endocrinol.. Sep. 2022 doi: 10.1186/s12958-022-01012-2.

Adenomyosis decreases the live birth rate but may not affect perinatal outcomes in assisted reproductive cycles.
Trinchant R, Cruz M, Requena A

Int J Gynaecol Obstet. 2022 May 6. Online ahead of print. 2022 doi: 10.1002/ijgo.14256

Association between clinical and IVF laboratory parameters and miscarriage after single euploid embryo transfers.
Del Carmen Nogales M, Cruz M, de Frutos S, Martínez EM, Gaytán M, Ariza M, Bronet F, Garcia-Velasco JA

Reprod Biol Endocrinol. 2021 doi:

How to provide fertility treatment during COVID-19 pandemic.
Cruz M, Requena A

Curr Opin Obstet Gynecol. Mar. 2021 doi: 10.1097/GCO.0000000000000705

Serum anti-Müllerian hormone levels are not associated with aneuploidy rates in human blastocysts.
Pipari A, Guillen A, Cruz M, Pacheco A, Garcia-Velasco JA

Reprod BioMed Online. Apr. 2021 doi: 10.1016/j.rbmo.2021.03.006

Early Pregnancy Outcomes in Fresh Versus Deferred Embryo Transfer Cycles for Endometriosis-Associated Infertility: A Retrospective Cohort Study.
Tan J, Cerrillo M, Cruz M, Cecchino GN, Garcia-Velasco J A

J Clin Med. Jan. 2021 doi: 10.3390/jcm10020344

Serum anti-Mullerian hormone levels are not associated with aneuploidy rates in human blastocysts
Pipari A, Guillen A, Cruz M, Pacheco A, Garcia-Velasco J A,

Reprod Biomed Online. Mar. 2021 doi: 10.1016/j.rbmo.2021.03.006

How to provide fertility treatment during COVID-19 pandemic
Cruz M, Requena A,

Curr Opin Obstet Gynecol. Jun. 2021 doi: 10.1097/GCO.0000000000000705

Early Pregnancy Outcomes in Fresh Versus Deferred Embryo Transfer Cycles for Endometriosis-Associated Infertility: A Retrospective Cohort Study
Tan J, Cerrillo M, Cruz M, Cecchino G N, Garcia-Velasco J A,

J Clin Med. Jan. 2021 doi: 10.3390/jcm10020344

Magnetic-Activated Cell Sorting (MACS): A Useful Sperm-Selection Technique in Cases of High Levels of Sperm DNA Fragmentation
Pacheco A, Blanco A, Bronet F, Cruz M, Garcia-Fernandez J, Garcia-Velasco J A,

J Clin Med. 2020 Dec. doi: 10.3390/jcm9123976

Infertility and reproductive rights after the COVID-19 pandemic
Trinchant R M, Cruz M, Marqueta J, Requena A,

Reprod Biomed Online. 2020 Aug. doi: 10.1016/j.rbmo.2020.05.007

A picture of the covid-19 impact on IVIRMA fertility treatment clinics in Spain and Italy
Requena A, Cruz M, Vergara V, Prados N, Galliano D, Pellicer A,

Reprod Biomed Online. 2020 Jul. doi: 10.1016/j.rbmo.2020.04.015

Frozen embryo transfer after pgt-a cycles: To wait or not to wait?
Cerrillo M, Cruz M, Basile N, Guillen A, Bronet F, Garcia-Velasco J A,

Medicina Reproductiva y Embriología Clínica. 2020 doi: 10.1016/j.medre.2020.09.003

Donor IUI is equally effective for heterosexual couples, single women and lesbians, but autologous IUI does worse
Soares S R, Cruz M, Vergara V, Requena A, Garcia-Velasco J A,

Hum Reprod. 2019 1-Nov. doi: 10.1093/humrep/dez179

Use of granulocyte colony-stimulating factor in ART treatment does not increase the risk of adverse perinatal outcomes
Cruz M, Alecsandru D, Garcia-Velasco J A, Requena A,

Reprod Biomed Online. 2019 Dec. doi: 10.1016/j.rbmo.2019.09.008

Impact of hypogonadotropic hypogonadism on ovarian reserve and response
Cecchino G N, Canillas G M, Cruz M, Garcia-Velasco J A,

J Assist Reprod Genet. 2019 Nov. doi: 10.1007/s10815-019-01587-7

Is the transport of frozen embryos a good option to improve results in a transnational oocyte donation program?
Requena A, Cruz M, Pellicer A,

Hum Reprod. 2019 8-Jul. doi: 10.1093/humrep/dez093

Serum and follicular fluid Stem Cell Factor assay in IVF poor responder and normal responder patients: a predictive biomarker of oocyte retrieval
Cozzolino M, Cruz M, Patel A, Patel J, Pacheco A, Garcia-Velasco J A,

Arch Gynecol Obstet. 2019 Aug. doi: 10.1007/s00404-019-05172-2

Small-sized follicles could contribute to high-order multiple pregnancies: outcomes of 6552 intrauterine insemination cycles
Giles J, Cruz M, Gonzalez-Ravina C, Caligara C, Prados N, Martinez J C, Vergara V, Requena A,

Reprod Biomed Online. 2018 Nov. doi: 10.1016/j.rbmo.2018.08.019

Pancreatic autoimmunity: An unknown etiology on patients with assisted reproductive techniques (ART)-recurrent reproductive failure
Alecsandru D, Barrio A, Andia V, Cruz E, Aparicio P, Serna J, Cruz M, Pellicer A, Garcia-Velasco J A,

PLoS One. 2018 doi: 10.1371/journal.pone.0203446

Very low anti-mullerian hormone concentrations are not an independent predictor of embryo quality and pregnancy rate
Pacheco A, Cruz M, Iglesias C, Garcia-Velasco J A,

Reprod Biomed Online. 2018 Jul. doi: 10.1016/j.rbmo.2018.03.015

Impact of vitamin D levels on ovarian reserve and ovarian response to ovarian stimulation in oocyte donors
Fabris A M, Cruz M, Iglesias C, Pacheco A, Patel A, Patel J, Fatemi H, Garcia-Velasco J A,

Reprod Biomed Online. 2017 Aug. doi: 10.1016/j.rbmo.2017.05.009

Type of gonadotropin used during controlled ovarian stimulation induces differential gene expression in human cumulus cells: A randomized study
Cruz M, Requena A, Agudo D, Garcia-Velasco J A,

Eur J Obstet Gynecol Reprod Biol. 2017 Aug. doi: 10.1016/j.ejogrb.2017.06.014

Economic impact of ovarian stimulation with corifollitropin alfa versus conventional daily gonadotropins in oocyte donors: a randomized study
Cruz M, Alama P, Muñoz M, Collado D, Blanes C, Solbes E, Requena A,

Reprod Biomed Online. 2017 Jun. doi: 10.1016/j.rbmo.2017.03.003

Impact of very low anti-Mullerian hormone on pregnancy success
Pacheco A, Cruz M, Garcia-Velasco J A,

Curr Opin Obstet Gynecol. 2017 Jun. doi: 10.1097/GCO.0000000000000354

Ethnicity is an independent predictor of IVF-ICSI outcome: a study of 5,549 cycles in Spain and India
Patel A P, Patel J A, Cruz M, Gupte-Shah A, Garcia-Velasco J A, Banker M R,

Gynecol Endocrinol. 2016 Oct. doi: 10.1080/09513590.2016.1188377

Assisted reproductive techniques after fertility-sparing treatments in gynaecological cancers
Zapardiel I, Cruz M, Diestro M D, Requena A, Garcia-Velasco J A,

Hum Reprod Update. 2016 Apr. doi: 10.1093/humupd/dmv066

Type of gonadotropin during controlled ovarian stimulation affects the endocrine profile in follicular fluid and apoptosis rate in cumulus cells
Requena A, Cruz M, Agudo D, Pacheco A, Garcia-Velasco J A,

Eur J Obstet Gynecol Reprod Biol. 2016 Feb. doi: 10.1016/j.ejogrb.2015.12.018

Dual Triggering with Gonadotropin-Releasing Hormone Agonist and Standard Dose Human Chorionic Gonadotropin in Patients with a high Immature Oocyte Rate.
Fabris A, Cruz M, Legidos V, Iglesias C, Muñoz M, Garcia-Velasco J A,

Reprod Sci. 2016 doi:

Exccesive age-related decline in functional ovarian reserve in infertile women: prospective cohort of 15500 women.
Iliodromiti S, Iglesias C, Messow CM, Cruz M, Garcia-Velasco J A, Nelson SM,

J Clin Endocrinol Metab. 2016 doi:

Excessive Age-Related Decline in Functional Ovarian Reserve in Infertile Women: Prospective Cohort of 15,500 Women.
Iliodromiti S, Iglesias C, Messow CM, Cruz M, Garcia-Velasco J A, Nelson SM,

J Clin Endocrinol Metab. 2016 doi:

Type of gonadotropin during controlled ovarian stimulation affects the endocrine profile in follicular fluid and apoptosis rate in cumulus cells.
Requena A, Cruz M, Agudo D, Pacheco A, Garcia-Velasco J A,

Eur J Obstet Gynecol Reprod Biol. 2016 doi:

Ongoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels
Requena A, Cruz M, Pacheco A, Garcia-Velasco J A,

Fertil Steril. 2015 Oct. doi: 10.1016/j.fertnstert.2015.06.026

Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients
Fabris A, Pacheco A, Cruz M, Puente J M, Fatemi H, Garcia-Velasco J A,

Fertil Steril. 2014 Dec. doi: 10.1016/j.fertnstert.2014.08.030

High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study
Requena A, Cruz M, Bosch E, Meseguer M, Garcia-Velasco J A,

Reprod Biol Endocrinol. 2014 26-Jul. doi: 10.1186/1477-7827-12-69

Endocrine profile following stimulation with recombinant follicle stimulating hormone and luteinizing hormone versus highly purified human menopausal gonadotropin
Requena A, Cruz M, Ruiz F J, Garcia-Velasco J A,

Reprod Biol Endocrinol. 2014 Jan 29. doi: 10.1186/1477-7827-12-10

High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study.
Requena A, Cruz M, Bosch E, Meseguer M, Garcia-Velasco J A,

Reprod Biol Endocrinol 2014; 26:69. 2014 doi:

Succesful twin delivery following transmyometrial embryo transfer in a patient with a false uterine cavity.
Muñoz M, Galindo N, Perez I-Cano, Cruz M, Garcia-Velasco J A,

RBM Online. 2014 doi:

Successful twin delivery following transmyometrial embryo transfer in a patient with a false uterine cavity.
Muñoz M, Galindo N, Perez-Cano I, Cruz M, Garcia-Velasco J A,

RBM Online. 2014 doi:

Evaluation of the degree of satisfaction in oocyte donors using sustained-release FSH corifollitropin ?.
Requena A, Cruz M, Collado D, Izquierdo A, Ballesteros A, Muñoz M, Garcia-Velasco J A,

RBM Online. 2013 doi:

Is morphokinetic analysis the answer?
Aparicio B, Cruz M, Meseguer M,

RBM Online. 2013 doi:

Oocyte insemination techniques are related to alterations of embryo developmental timing in an oocyte donation model.
Cruz M, Garrido N, Gadea B, Muñoz M, Perez-Cano I, Meseguer M,

RBM Online. 2013 doi:

The type of GnRH analogue used during controlled ovarian stimulation influences early embryo developmental kinetics: a time-lapse study.
Muñoz M, Cruz M, Humaidan P, Garrido N, Perez-Cano I, Meseguer M,

Eur J Obstet Gynecol Reprod Biol. 2013 doi:

Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: a retrospective cohort study
Meseguer M, Rubio I, Cruz M, Basile N, Marcos J, Requena A,

Fertil Steril. 2012 Dec. doi: 10.1016/j.fertnstert.2012.08.016

Dose of recombinant FSH and oestradiol concentration on day of HCG affect embryo development kinetics
Muñoz M, Cruz M, Humaidan P, Garrido N, Perez-Cano I, Meseguer M,

Reprod Biomed Online. 2012 Oct. doi: 10.1016/j.rbmo.2012.06.016

Timing of cell division in human cleavage-stage embryos is linked with blastocyst formation and quality
Cruz M, Garrido N, Herrero J, Perez-Cano I, Muñoz M, Meseguer M,

Reprod Biomed Online. 2012 Oct. doi: 10.1016/j.rbmo.2012.06.017

Dose of recombinant FSH and estradiol concentration on day of HCG affect embryo development kinetics.
Muñoz M, Cruz M, Humaidan P, Garrido N, Perez-Cano I, Meseguer M,

RBM Online. 2012 doi:

Timing of cell divisions in human cleavage stage embryos correlate with blastocyst formation and quality.
Cruz M, Garrido N, Herrero J, Perez-Cano I, Muñoz M, Meseguer M,

RBM Online. 2012 doi:

Embryo quality, blastocyst and ongoing pregnancy rates in oocyte donation patients whose embryos were monitored by time-lapse imaging
Cruz M, Gadea B, Garrido N, Pedersen K S, Martinez M, Perez-Cano I, Muñoz M, Meseguer M,

J Assist Reprod Genet. 2011 Jul. doi: 10.1007/s10815-011-9549-1

Aplicación de la tecnología del embryoscope para la cuentificación de la calidad ovocitaria mediante el análisis de los patrones de respiración.
Herrero J, Tejera A, Cruz M, Meseguer M,

ASEBIR. 2011 doi:

Cinematografía para el estudio de la calidad embrionaria. Embryoscope
Herrero J, Tejera A, Cruz M, Meseguer M,

ASEBIR. 2011 doi:

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Presentations

Giles J Cruz M Alamá P Laura Caracena Vidal C Bosch E P-863 PROGNOSTIC FACTORS OF OVARIAN RESPONSE AFTER FOLLICULAR PROTOCOL WITH MPA TRIGGER WITH GnRH AGONIST.. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Agudo D Castro E Pacheco A Irene Martín Patón Cruz M Bronet F O-107 DOES TOBACCO AFFECT FOLLICULAR AND EMBRYO HEALTH?. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Prados N González-Ravina C Vergara V Javier Herrero Cruz M Requena A P-980 RISK FACTOR ANALYSIS FOR SARS-COV-2 SEROPOSITIVITY WITHIN ASSISTED REPRODUCTIVE. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Cruz M Ruiz ME P-1011 HP-HMG IN MONOTHERAPY IMPROVES CLINICAL OUTCOMES IN YOUNG WOMEN. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Ortega I Alvarez de la Fuente A Sonia Matey Elizabet Henzenn Cruz M Pacheco A Antoni Duleba Garcia-Velasco JA P-854 RESVERATROL FOR PREVENTING OVARIAN HYPERSTIMULATION SYNDROME IN WOMEN AT RISK UNDERGOING EGG DONATION: A RANDOMIZED CONTROLLED STUDY. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Cruz M Vergara V Requena A P-857 TYPE OF FOLLITROPIN ALFA FOR OVARIAN STIMULATION WITH MEDROXYPROGESTERONE ACETATE DOES NOT AFFECT CLINICAL OUTCOMES IN A DONOR-RECIPIENT PROGRAM. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

González-Ravina Vergara V Cruz M Prados N Requena A O-146 Is COVID-19 symptomatic triage enough? The limited value of serological testing. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology, Copenhagen,Denmark, July 5-8, 2020

Cecchino G Cerrillo M Cruz M Garcia Velasco J Retrospective analysis of DuoStim cycles shows similar overall performance and oocyte quality between follicular and luteal phase stimulation. Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology, Geneva,Switerland, July 1-4,2018

Cruz M Alecsandru D Garcia Velasco J Requena A Use of granulocyte colony-stimulating factor during an assisted reproductive treatment does not increase the risk of birth defects. Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology, Geneva,Switerland, July 1-4,2018

Cerrillo M Cruz M Ferrando R García Velasco JA Freeze-all strategy in endometriosis patients - a new indication?. , , July 2-5 ,2017

González-Ravina C Cruz M Rubio C Fernández-Sánchez M Oquiñena E Ferrando R Requena A Polymorphic chromosome variants, human inversions, and their functional consequences in male infertility 2017

Rubio Lluesa C Cruz M González-Ravina C Fernández-Sánchez M Oquiñena E Requena A Polymorphism on chromosome 21 does not affect ovarian reserve but clinical outcomes after in vitro fertilization treatments 2017

Sánchez M Pacheco A Cruz M Requena A Assessment of sperm ploidy status by flow cytommetry correlates to embryo quality 2017

Vergara Bravo V Cruz M Goyri E Requena A Pituitary suppression protocol does affect clinical outcomes in egg donation cycles 2017

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