Patricia Diaz_FIVI_c

Patricia Díaz Gimeno, Ph.D.

Research group leader in Genomics & Systems Reproductive Medicine

FIVI Valencia

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Patricia Díaz Gimeno, Ph.D.

Biography

Dr. Diaz-Gimeno is a full-time researcher at FIVI-INCLIVA, leading the Genomic & Systems Reproductive Medicine research line. She is also the Bioinformatics Director of IVI Foundation Research Department. She obtained her Bachelor’s degree in Biological Sciences with a focus on Genetics (2006) with Excellence Award (2007) and Ph.D. in Biomedicine “cum laude” in the Department of Pediatrics, Obstetrics and Gynaecology at University of Valencia School of Medicine (2011).

Her Ph.D. research was on the transcriptomic signature of endometrial receptivity as a biomarker and its clinical application. She developed further expertise in high throughput technologies (microarrays and next generation sequencing) and their related functional genomics analyses during her post-doctoral training at the Genomics and Bioinformatics department of CIPF (Principe Felipe Research Center) (2011-2013). Since 2013, Dr. Diaz-Gimeno established the Bioinformatics Laboratory at FIVI and worked intensively for the translation of endometrial transcriptomics as a diagnostic method for endometrial evaluation.

As a researcher, her main focus is to apply genomic approaches for precision reproductive medicine in ARTs and to understand the molecular basis of human infertility using functional genomics approaches from a systems biology perspective. Dr. Diaz-Gimeno has worked intensively for the implantation failure patient stratification using transcriptomics predictors and for understanding the molecular basis of the menstrual cycle and comorbidities of endometrial subfertility.

Dr. Diaz-Gimeno authored or co-authored seventeen original articles published in high impact international journals in the field of reproduction (Fertil & Steril, Hum Reprod, PLos One, JCEM, etc.). She also wrote 5 book chapters on transcriptomics of endometrial factor, and had more than 20 presentations at scientific meetings.

Dr. Diaz-Gimeno has been involved in teaching since her early career, participating as a Faculty in postgraduate courses since 2007. Currently, she is the coordinator of the “genomic reproductive medicine” course in the Master’s Program in Biotechnology of Assisted Human Reproduction at ADEIT (University of Valencia). She is also teaching in the Master’s Degree in Genetic & Genomic Medicine (Rey Juan Carlos University) and the Master’s Degree in Bioinformatics (University of Valencia) programs, and is supervising M.Sc. projects and Ph.D. theses.


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Education and Training

B.Sc. University of Valencia, Valencia Spain (2006)
Predoctoral Stay NIRRH Molecular and Cellular reproductive biology, Bombay, India (2010)
Ph.D University of Valencia, Valencia Spain (2011)
Postdoctoral training CIPF Genomics & Bioinformatics department, Valencia, Spain (2013)

Publications


  • Does an increased body mass index affect endometrial gene expression patterns in infertile patients? A functional genomics analysis.
    Comstock IA, Diaz-Gimeno P, Cabanillas S, Bellver J, Sebastian-Leon P, Shah M, Schutt A, Valdes CT, Ruiz-Alonso M, Valbuena D, Simon C, Lathi RB.
    Fertil Steril, 107:740-48. e2, 2017.

  • Leucine-rich repeat-containing G-protein-coupled receptor 5-positive cells in the endometrial stem cell niche.
    Cervelló I, Gil-Sanchis C, Santamaría X, Faus A, Vallvé-Juanico J, Díaz-Gimeno P, Genolet O, Pellicer A, Simón C.
    Fertil Steril, 107:510-19. e3, 2017.

  • Intrauterine human chorionic gonadotropin infusion in oocyte donors promotes endometrial synchrony and induction of early decidual markers for stromal survival: a randomized clinical trial.
    Strug MR, Su R, Young JE, Dodds WG, Shavell VI, Díaz-Gimeno P, Ruíz-Alonso M, Simón C, Lessey BA, Leach RE, Fazleabas AT.
    Hum Reprod, 31:1552-61, 2016.


  • Human somatic cells subjected to genetic induction with six germ line-related factors display meiotic germ cell-like features.
    Medrano JV, Martínez-Arroyo AM, Míguez JM, Moreno I, Martínez S, Quiñonero A, Díaz-Gimeno P, Marqués-Marí AI, Pellicer A, Remohí J, Simón C.
    Sci Rep, 6:24956, 2016.

  • Mitochondrial DNA content as a viability score in human euploid embryos: less is better.
    Diez-Juan A, Rubio C, Marin C, Martinez S, Al-Asmar N, Riboldi M, Díaz-Gimeno P, Valbuena D, Simón C.
    Fertil Steril, 104:534-41. e1, 2015.

  • Deciphering the proteomic signature of human endometrial receptivity.
    Garrido-Gómez T, Quiñonero A, Antúnez O, Díaz-Gimeno P, Bellver J, Simón C, Domínguez F.
    Hum Reprod, 29:1957-67, 2014.

  • Transcriptomics of the human endometrium.
    Díaz-Gimeno P, Ruíz-Alonso M, Blesa D, Simón C.
    Int J Dev Biol, 58:127-37, 2014.

  • The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.
    Ruiz-Alonso M, Blesa D, Díaz-Gimeno P, Gómez E, Fernández-Sánchez M, Carranza F, Carrera J, Vilella F, Pellicer A, Simón C.
    Fertil Steril, 100:818-24, 2013.

  • Defining the genomic signature of totipotency and pluripotency during early human development.
    Galan A, Diaz-Gimeno P, Poo ME, Valbuena D, Sanchez E, Ruiz V, Dopazo J, Montaner D, Conesa A, Simon C.
    PLoS One, 8: e62135, 2013.

  • Profiling the gene signature of endometrial receptivity: clinical results.
    Garrido-Gómez T, Ruiz-Alonso M, Blesa D, Diaz-Gimeno P, Vilella F, Simón C. Fertil Steril, 99:1078-85, 2013.

  • The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity.
    Díaz-Gimeno P, Ruiz-Alonso M, Blesa D, Bosch N, Martínez-Conejero JA, Alamá P, Garrido N, Pellicer A, Simón C.
    Fertil Steril, 99:508-17, 2013.

  • A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature.
    Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Alamá P, Pellicer A, Simón C.
    Fertil Steril, 95:50-60, 60. e1-15, 2011.

  • Uterine receptivity and the ramifications of ovarian stimulation on endometrial function.
    Horcajadas JA, Díaz-Gimeno P, Pellicer A, Simón C.
    Semin Reprod Med, 25:454-60, 2007.

  • Genetic markers of endometrial receptivity.
    Diaz-Gimeno P*, García-Velasco JA.
    In: How to Improve the Endometrium to Maximize IVF Success edited by Dr. Gabor Kovacs and Dr. Lois Salamonsen. Cambridge University press, In press. 2017. *Correspondence author

  • Psychological Aspects of Female Reproductive Medicine.
    Dolz del Castellar P, Nohales-Córcoles M, Diaz-Gimeno P.
    In: Biomedical Research. Encyclopedia of Reproduction, 2nd Edition. In press, 2017.

  • Endometrial Development and Gene Expression.
    Rincón A, Ruiz-Alonso M, Diaz-Gimeno P, Vilella F, Simon C.
    In: Early Pregnancy edited by Roy G. Farquharson and Mary D. Stephenson, 2nd Edition. Cambridge University press, 2017.

  • El Paso de la Medicina Anatómica a la Medicina Molecular: ¿Qué es un microarray?
    Díaz-Gimeno P, Horcajadas JA.
    In: Simon C; Horcajadas JA; Garcia-Velasco JA; Pellicer A. El Endometrio Humano: De La Investigación A La Clínica. Médica Panamericana. Buenos Aires, Madrid, 2009.

  • Estudio Genómico Del Endometrio Humano En Ciclos Naturales Y Estimulados Díaz-Gimeno P, Loro F, Valbuena D, Horcajadas JA.
    In: Simon C; Horcajadas JA; Garcia-Velasco JA; Pellicer A. El Endometrio Humano: De La Investigación A La Clínica. Médica Panamericana. Buenos Aires, Madrid, 2009.


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