Coasting for the prevention of ovarian hyperstimulation syndrome: much ado about nothing?

Garcia-Velasco, J A, Isaza, V, Quea, G, Pellicer, A,
Fertil Steril. Mar. 2006 doi: 10.1016/j.fertnstert.2005.07.1335


OBJECTIVE: To review and critique the literature and our own experience regarding coasting as a strategy to prevent ovarian hyperstimulation syndrome (OHSS). DESIGN: Identification of relevant clinical literature through PubMed and EMBASE databases, as well as the experience of our institution with this approach. CONCLUSION(S): Coasting is a rescue procedure that can be avoided by carefully adjusting the gonadotropin dosage. It is a good alternative that can be used to avoid cycle cancellation in extremely high responders to controlled ovarian hyperstimulation, who have a high risk of developing severe OHSS. Even if OHSS develops after coasting, both its incidence and severity will be diminished. Each case should be individually counseled to determine whether the patient should be coasted, and her hypothetical risks and benefits should be evaluated. Until the multifactorial etiopathogenesis of OHSS is completely understood, absolute prevention will not be possible, but coasting is definitely of great benefit.