José Serna, M.D., Ph.D.

Director of IVI Zaragoza

IVI Zaragoza

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José Serna, M.D., Ph.D.


Dr. José Serna is the Medical Director of IVI Zaragoza where he combines his management duties with his medical practice. He obtained his M.D. degree in 1993 at the Hospital Militar Universitario del Ejercito del Aire, Universidad Complutense de Madrid. During his last year at school, he pursued his enthusiasm in biology and basic research and was enrolled in the Growth Factor Laboratory at the Developmental Biology Department at Centro de Investigaciones Biológicas (CSIC) in Madrid. After competing medical school, he gained a predoctoral fellowship to investigate the role of insulin family of growth factors in embryo development. He then obtained his Ph.D. in Molecular Biology and Biochemistry and moved forward in basic research obtaining a Marie Curie Post-doctoral Fellowship fulfilling simultaneously clinical training and basic research in the Pediatrics Department at St. Bartholomew Hospital in London.

In 2000, he started his residency training in Obstetrics and Gynecology in Fundación Jiménez Díaz with a special interest in Gynecological Endocrinology and Reproduction. He also worked as an Assistant Professor at Universidad Autónoma de Madrid Medical School and Nursing School. After his specialization, he joined IVI group as an attending physician at IVI Madrid for four years. Then he moved to IVI Bilbao as Chief Medical Officer and afterwards, in 2009, to IVI Zaragoza. He has been certified with the ESHRE Certification for Reproductive Endoscopic Surgeons.

Dr. Serna teaches in several University Degree Programs and collaborates actively as lecturer and instructor in Experimental Surgery at Instituto Aragonés de Ciencias de la Salud (IACS). He is the director of several Master’s Theses in the field of gynecology and embryology. He acts as advisor in translational research in the Reproduction Medicine Group of the IACS. He belongs to the IVI Foundation where he conducts several research projects and he has received public and private funding for his research.

Dr. Serna had numerous presentations in national and international meetings and has written and contributed to more than 100 publications, book chapters and conference proceedings. He is an Ad Hoc reviewer for leading reproductive journals including Fertility and Sterility, Human Reproduction, Human Fertility and Reproductive Biomedicine Online.

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MD Universidad Complutense de Madrid (1993)
Fellowship Centro de Investigaciones Biológicas. Consejo Superior de Investigaciones Científicas (CSIC) Madrid. (1998)
PhD Department of Biochemistry and Molecular Biology. Universidad Complutense de Madrid (1998)
Postdoctoral Dpt. Pediatrics. Saint Bartholomew Hospital. London (1999)
SUD Reproductive Medicine. Universidad Nacional de Educación a Distancia (2003)
Residency Fundación Jiménez Díaz. Madrid (2006)


  • Pros and cons of implementing a carrier genetic test in an infertility practice.
    Gil-Arribas E, Herrer R, Serna J.
    Curr Opin Obstet Gynecol, 28(3):172–7, 2016.

  • Effects of adipocyte-secreted factors on decidualized endometrial cells: modulation of endometrial receptivity in vitro.
    Gamundi-Segura S, Serna J, Oehninger S, Horcajadas JA, Arbones-Mainar JM.
    J Physiol Biochem 71(3):537–46, 2015.

  • Health outcomes of children born after IVF/ICSI: A review of current expert opinion and literature.
    Fauser BCJM, Devroey P, Diedrich K, Balaban B, Bonduelle M, Delemarre-Van De Waal HA, Estella C, Ezcurra D, Geraedts JPM, Howles CM, Lerner-Geva L, Serna J, Wells D.
    Reproductive BioMedicine Online, (18):162–82, 2014.

  • An engaging example of translational medicine: the Wnt/β-catenin cellular pathway and pharmacological research in fibroid treatment.
    Serna J.
    Fertil Steril, 101(5):1254, 2014.

  • Systemic methotrexate to treat ectopic pregnancy does not affect ovarian reserve.
    Oriol B, Barrio A, Pacheco A, Serna J, Zuzuarregui JL, Garcia-Velasco JA.
    Fertil Steril, 90(5):1579–82, 2008.

  • Estradiol supplementation during the luteal phase of IVF-ICSI patients: a randomized, controlled trial.
    Serna J, Cholquevilque JL, Cela V, Martinez-Salazar J, Requena A, Garcia-Velasco JA.
    Fertil Steril, 90(6):2190–5, 2008.

  • Effect of repeated assisted reproduction techniques on the ovarian response.
    Serna J, Garcia-Velasco JA.
    Curr Opin Obs Gynecol. 17(3):233–6, 2005.

  • New trends in IVF. Is there any evidence?
    Serna J, Pellicer A.
    In: Controversies in Obstetrics Gynecology and Infertility, 141–4, 2005.

  • Unprocessed proinsulin promotes cell survival during neurulation in the chick embryo.
    Hernandez-Sanchez C, Rubio E, Serna J, de la Rosa EJ, de Pablo F. Diabetes, 51(3):770–7, 2002.

  • In vivo regulation of cell death by embryonic (pro)insulin and the insulin receptor during early retinal neurogenesis.
    Diaz B, Serna J, De Pablo F, de la Rosa EJ.
    Development, 127(8):1641–9, 2000.

  • (Pro)insulin and insulin-like growth factor I complementary expression and roles in early development.
    Alarcon C, Morales A V, Pimentel B, Serna J, de Pablo F.
    Comp Biochem Physiol B Biochem Mol Biol. 121(1):13–7, 1998.

  • Synthesis and differentially regulated processing of proinsulin in developing chick pancreas, liver and neuroretina.
    Alarcón C, Serna J, Pérez-Villamil B, de Pablo F.
    FEBS Lett, 436(3):361–6, 1998.

  • Modulation of the chaperone heat shock cognate 70 by embryonic (pro)insulin correlates with prevention of apoptosis.
    De la Rosa EJ, Vega-Nunez E, Morales AV, Serna J, Rubio E, de Pablo F.
    Proc Natl Acad Sci USA, 95(17):9950–5, 1998.

  • Flow cytometric analysis of whole organs and embryos.
    Serna J, Pimentel B, de la Rosa EJ.
    Curr Top Dev Biol, 36:211–22, 1998.

  • Role of prepancreatic (pro)insulin and the insulin receptor in prevention of embryonic apoptosis.
    Morales A V, Serna J, Alarcon C, de la Rosa EJ, de Pablo F. Endocrinology, 138(9):3967–75, 1997.

  • Complementary roles of the insulin family of factors and receptors in early development and neurogenesis.
    De Pablo F, Alarcon C, Diaz B, Garcia-De Lacoba M, Lopez-Carranza A, Morales AV, Pimentel B, Serna J, De la Rosa EJ.
    Int J Dev Biol, Suppl 1:109S–110S, 1996.

  • Differential and tissue-specific regulation of (pro)insulin and insulin-like growth factor-I mRNAs and levels of thyroid hormones in growth-retarded embryos.
    Serna J, Gonzalez-Guerrero PR, Scanes CG, Prati M, Morreale G, de Pablo F.
    Growth Regul, 6(2):73–82, 1996.

  • Et al. IGF-I and the IGF-I receptor in development of nonmammalian vertebrates.
    De Pablo F, Perez-Villamil B, Serna J, Gonzalez-Guerrero PR, Lopez-Carranza A, de la Rosa EJ,
    Mol Reprod Dev, 35(4):423–7, 1993.

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