Células madre
La capacidad regenerativa de las células madre hace que sean una opción fascinante para tratar diversas patologías asociadas con la infertilidad.
El equipo científico de IVIRMA Global ha lanzado varios estudios en diferentes campos de la reproducción gracias al uso de células madre. Los primeros datos obtenidos en un estudio prospectivo con pacientes con síndrome de Asherman (o con una cavidad uterina muy dañada) o que presentan atrofia endometrial (problemas durante el crecimiento del endometrio) sugieren que se puede mejorar el crecimiento endometrial y reducir el daño en el tejido mediante el trasplante de células madre procedentes de la médula ósea. Otros estudios han utilizado la inyección de células madre para vascularizar el tejido del ovario e intentar revertir el efecto que el envejecimiento prematuro del ovario pueda producir.
Por otra parte, nuestros investigadores están estudiando formas para el aislamiento y cultivo in vitro de células madre espermatogénicas con el objetivo de mejorar la producción de semen para aquellos pacientes con azoospermia.
Investigadores trabajando en este área
Públicaciones en este área
- Stem cell paracrine actions in tissue regeneration and potential therapeutic effect in human endometrium: a retrospective study.
De Miguel-Gómez L Ferrero H López-Pérez N Faus A Hervás D Santamaria X Pellicer A Cervelló I
BJOG. 2019 Dec 25. doi: 10.1111/1471-0528.16078. [Epub ahead of print]
- Happy Birthday to ASRM from Fertility and Sterility.
Niederberger C Pellicer A Simon C
Fertil Steril. 2019 Oct;112(4S1):e1. doi: 10.1016/j.fertnstert.2019.08.098. No abstract available.
- Endometrial Stromal Cells Circulate in the Bloodstream of Women with Endometriosis: A Pilot Study.
Vallvé-Juanico J López-Gil C Ballesteros A Santamaria X
Int J Mol Sci. 2019 Jul 31;20(15). pii: E3740. doi: 10.3390/ijms20153740.
- New Frontiers in IVF: mtDNA and autologous germline mitochondrial energy transfer.
Cozzolino M Marin D Sisti G
Reprod Biol Endocrinol. 2019 Jul 12;17(1):55. doi: 10.1186/s12958-019-0501-z. Review.
- Treatment potential of bone marrow-derived stem cells in women with diminished ovarian reserves and premature ovarian failure.
Herraiz S Pellicer N Romeu M Pellicer A
Curr Opin Obstet Gynecol. 2019 Feb 21. doi: 10.1097/GCO.0000000000000531. [Epub ahead of print]
- Reply: Bone marrow-derived endometrial cells: what you see is what you get.
Santamaria X Mas A Cervelló I Taylor HS Simon C
Hum Reprod Update. 2018 Dec 21. doi: 10.1093/humupd/dmy042. [Epub ahead of print] No abstract available.
- Human Endometrial Reconstitution From Somatic Stem Cells: The Importance of Niche-Like Cells.
Lopez-Perez N Gil-Sanchis C Ferrero H Faus A Diaz A Pellicer A Cervelló I Simón C
Reprod Sci, NA:NA-NA, 2018.
- Role of Stro1+/CD44+ stem cells in myometrial physiology and uterine remodeling during pregnancy.
Mas A Prusinski L Yang Q Díaz-Gimeno P Stone L Diamond MP Simón C Al-Hendy A
Biol Reprod. 2017 Jan 1;96(1):70-80. doi: 10.1095/biolreprod.116.14346
- Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study.
Santamaria X Cabanillas S Cervelló I Arbona C Raga F Ferro J Palmero J Remohí J Pellicer A Simón C
Hum Reprod, 31(5):1087-96, 2016
- Translating Regenerative Medicine to the Clinic. Advances in Translational Medicine. Regenerative Medicine and Tissue Engineering in Reproductive Medicine: Future Clinical Applications in Human Infert
Cervelló I Medrano JV Simón C
Elsevier Inc. 2016
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Presentaciones en esta área
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Simon C Gómez C Cabanillas S Vladimirov IK Castillón G Giles J Boynukalin FK Findikli N Ortega I Vidal C Izquierdo A Portela S Frantz N Taguchi S Labarta E Colucci F Mackens S Santamaría X Muñoz E Barrera SG Fernandez-Sanchez M Ferrando MPellicer A Mol BW Valbuena D O-134 IN VITRO FERTILIZATION WITH PERSONALIZED BLASTOCYST TRANSFER VERSUS FROZEN OR FRESH BLASTOCYST TRANSFER: A MULTICENTER, RANDOMIZED CLINICAL TRIAL Presented at 75th American Society of Reproductive Medicine Scientific Congress
ASRM 2019
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Pellicer N Buigues A Dominguez F Susana Martinez-cuenca Pellicer A Herraiz S
P-787 Autologous stem cell ovarian transplantation (ASCOT) revitalized the aged blood-borne secretome in Poor responder (PR) women
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Hanson BM Kim G Osman EK Tiegs AW Neal SA Lathi RB Scott RT Franasiak JM
P-264 THE IMPACT OF PATERNAL AGE ON REPRODUCTIVE OUTCOMES IN THE SETTING OF A EUPLOID SINGLE EMBRYO TRANSFER ACHIEVED WITH SURGICALLY EXTRACTED SPERM
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Grau Gonzalez-Picazo A Soler N Escribá MJ Vendrell X Viloria T
P-417 Effect of different 6-dimethylaminopurine (6-DMAP) treatments on reversible arresting of mono and tripronuclear embryos at the pronuclear stage
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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López Martínez S Campo H De Miguel-Gómez L Faus A Ferrero H Cervelló I O-121: Improving three-dimensional in vitro culture methods of human endometrial stem cells: bioengineering tissue-specific hydrogels Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology
ESHRE 2019
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De Miguel Gómez L López Martínez S Faus A Hervás D Ferrero H Cervelló I
P-790: Stem cell therapy induces a shift from an inflammatory environment towards an immune tolerant scenario promoting endometrial tissue regeneration
Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology
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Campo H García-Domínguez X López-Martínez S Antón J Marco-jiménez F Cervelló I Biomimetic Coatings from Decellularized Rabbit Endometrium Inuence the In Vitro In Vitro Development of PreImplantation Embryos. Presented at the 66th Annual Meeting of the Society for Reproductive Investigation
SRI 2019
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Pellegrini L Buigues A Sebastián-León P Diaz-Gimeno P Pellicer A Herraiz S
Transcriptomic Changes and Paracrine Factors Involved in Ovarian Rejuvenation Induced by Stem Cell_
Presented at the 66th Annual Meeting of the Society for Reproductive Investigation
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López-Pérez N Santamaría X Díaz-Gimeno P Sebastian-Leon P Faus A Remohí J Pellicer A Simón C Cervelló I Stem Cell-Secreted Paracrine Factors in Human Endometrial Regeneration Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
SRI 2018
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Herraiz S Romeu M Martínez S Solves P Gómez I Martínez J Buigues A Galliano D Simón C Díaz-García C Pellicer A Two live birth after Stem cell ovarian auto-transplantation in Poor Responder women Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017
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Santamaría Costa X Cabanillas S Arbona C Cervelló I Raga F Ferro J Palmero J Remohí J Pellicer A Simon C
Stem cell treatment for endometrial pathologies
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Santamaría X Cervelló I Cabanillas S Arbona C Raga F Ferro J Palmero J Remohí J Pellicer A Simon C
Human Reproduction keynote lecture - Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Herraiz S Buigues A Romeu M Díaz-García C Hsueh A Pellicer A Infusion Of Human Bone Marrow-Derived Stem Cells Improved Ovarian Function In Chemotherapy-Damaged Ovaries In Mice Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
SRI 2017
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Herraiz S Romeu M Martínez S Díaz-García C Solves P Gómez I Martínez J Anna Buigues Simón C Galliano D Pellicer A
Two Live Birth After Stem Cell Ovarian Auto-Transplantation In PR Women
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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López-Pérez N Gil-Sanchis C Faus A Diaz A Campo H Pellicer A Cervelló I Carlos Simón
Human endometrial reconstitution using W5C5, ICAM1 cells and side population cell lines in a xenograft model
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation