Células madre
La capacidad regenerativa de las células madre hace que sean una opción fascinante para tratar diversas patologías asociadas con la infertilidad.
El equipo científico de IVIRMA Global ha lanzado varios estudios en diferentes campos de la reproducción gracias al uso de células madre. Los primeros datos obtenidos en un estudio prospectivo con pacientes con síndrome de Asherman (o con una cavidad uterina muy dañada) o que presentan atrofia endometrial (problemas durante el crecimiento del endometrio) sugieren que se puede mejorar el crecimiento endometrial y reducir el daño en el tejido mediante el trasplante de células madre procedentes de la médula ósea. Otros estudios han utilizado la inyección de células madre para vascularizar el tejido del ovario e intentar revertir el efecto que el envejecimiento prematuro del ovario pueda producir.
Por otra parte, nuestros investigadores están estudiando formas para el aislamiento y cultivo in vitro de células madre espermatogénicas con el objetivo de mejorar la producción de semen para aquellos pacientes con azoospermia.
Investigadores trabajando en este área
Públicaciones en este área
- Timing of spermatogonial stem cell transplantation affects the spermatogenic recovery outcome in mice.
Medrano JV Acimovic I Navarro-Gomezlechon A Noguera I Pellicer A Andrés MM Novella-Maestre E
In Vitro Cell Dev Biol Anim. 2021 Jan 8. doi: 10.1007/s11626-020-00531-9. Online ahead of print.
- Stem cell secreted factor therapy regenerates the ovarian niche and rescues follicles
Buigues A Marchante M Lucia de Miguel-Gómez Jessica Martinez Cervelló I Pellicer A Herraiz S
American Journal of Obstetrics and Gynecology Available online 1 February 2021 In Press, Journal Pre-proof
- Stem Cell Paracrine Signaling for Treatment of Premature Ovarian Insufficiency
Polonio AM Garcia Velasco J Herraiz S
Front. Endocrinol., 24 February 2021 | https://doi.org/10.3389/fendo.2020.626322
- (Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability
Gianzo M Urizar-Arenaza I Muñoa-Hoyos I Larreategui Z Garrido N Irazusta J Subirán N
Int. J. Mol. Sci. 2021, 22, 3215. https://doi.org/10.3390/ijms22063215
- Recurrent implantation failure might be overestimated without PGT-A.
Cozzolino M
Arch Gynecol Obstet. 2020 Sep 1. doi: 10.1007/s00404-020-05775-0. Online ahead of print.
- Stem cell paracrine actions in tissue regeneration and potential therapeutic effect in human endometrium: a retrospective study.
Miguel-Gómez L Ferrero H López-Martínez S Campo H López-Pérez N Faus A Hervás D Santamaría X Pellicer A Cervelló I
BJOG. 2020 Apr;127(5):551-560. doi: 10.1111/1471-0528.16078. Epub 2020 Jan 19.
- Estrategias de mejora de la fertilidad: preservación rejuvenecimiento y células madre.
Acosta-Bueno C Antonio Cejudo-Román Salazar-Vera A Quiroga-Gil R
Medicina Reproductiva y Embriología Clínica, Volume 7, Issue 1, JanuaryApril 2020, Pages 33-49
- Endometrial Stromal Cells Circulate in the Bloodstream of Women with Endometriosis: A Pilot Study.
Vallvé-Juanico J López-Gil C Ballesteros A Santamaria X
Int J Mol Sci. 2019 Jul 31;20(15). pii: E3740. doi: 10.3390/ijms20153740.
- New Frontiers in IVF: mtDNA and autologous germline mitochondrial energy transfer.
Cozzolino M Marin D Sisti G
Reprod Biol Endocrinol. 2019 Jul 12;17(1):55. doi: 10.1186/s12958-019-0501-z. Review.
- Treatment potential of bone marrow-derived stem cells in women with diminished ovarian reserves and premature ovarian failure.
Herraiz S Pellicer N Romeu M Pellicer A
Curr Opin Obstet Gynecol. 2019 Feb 21. doi: 10.1097/GCO.0000000000000531. [Epub ahead of print]
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Presentaciones en esta área
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Myriam M Armendariz E Herrera L Rodriguez C Roig N Garcia-Quevedo L Vidal F Diaz-Nuñez M Prieto M Matorras R Lopez-Almaraz R Solorzano E Chuva de Sousa Lopes SM A. van Pelt8 Future stem cell therapies in fertility preservation of prepuberal children with cancer or genetic syndromes. Improvements in the characterization of human Spermatogonial Stem Cells. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2020
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Marchante M Buigues A Pellicer A Herraiz S T-208 Stem Cell Secreted Factors-Enriched Plasma Promotes DNA Repair and Protects Against Chemotherapy-Induced Cell Death in Ovarian Tissue Presented at the 67th Annual Meeting of the Society for Reproductive Investigation
SRI 2020
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Ángel Martin Vidal C Rodrigo L Mercader A Rubio C Giles J Remohí J De los Santos MJ P-310 Impact of different degrees of genetic mosaicism in the kinetic profile of the human embryo Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2019
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Cozzolino M Cecchino G Garrido N
P-302 CONVENTIONAL PROTOCOL VERSUS MINIMAL OVARIAN STIMULATION IN PATIENTS WITH POOR REPRODUCTIVE PROGNOSIS ACCORDING TO THE POSEIDON CRITERIA
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Tiegs AW Tao X Whitehead CR Neal SA Osman EK Kim G Hanson BM Seli E Patounakis G Gutmann J Castlebaum A
O-74 DOES PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A) HARM EMBRYOS? NO—A MULTI-CENTER, PROSPECTIVE, BLINDED, NON-SELECTION STUDY EVALUATING THE PREDICTIVE VALUE OF AN ANEUPLOID DIAGNOSIS AND IMPACT OF BIOPSY
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Grau Gonzalez-Picazo A Soler N Escribá MJ Vendrell X Viloria T
P-417 Effect of different 6-dimethylaminopurine (6-DMAP) treatments on reversible arresting of mono and tripronuclear embryos at the pronuclear stage
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Pirtea P Marin D Sun L Hong K Zhan Y Tao X Scott RT Gonadotrophin receptor polymorphisms (fshr n680s and lhcgr n312s) are not of clinical outcome and live birth in ivf cycles Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
ASRM 2018
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López-Pérez N Santamaría X Díaz-Gimeno P Sebastian-Leon P Faus A Remohí J Pellicer A Simón C Cervelló I Stem Cell-Secreted Paracrine Factors in Human Endometrial Regeneration Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2018
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Cobo A Meseguer M Coello A Sanchez E Garcia Velasco J Remohí J Pellicer A Estimation of reproductive success according to age, number of oocytes and etiology in elective or oncological fertility preservation (FP) patients Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2017
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Coello A Sanchez E Campos P Vallejo B Meseguer M Cobo A
Oocyte dysmorphisms are not associated with post warming survival, fertilization and embryo development in own oocytes vitrification cycles
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Garnsey HM Eccles JM Iturriaga A Scott RT Zimmerman RS
Incidental diagnosis of a parental balanced reciprocal rearrangement in couples undergoing routine aneuploidy screening by targeted next generation sequencing (TNGS)
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Goodman L Khan Z Franasiak JM Juneau CR Morin SJ Neal SA Scott RT Goldberg JM
Current surgical experience and deficits in reproductive endocrinology and infertility training across fellowships in the United States
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Goodman L Yoo N Pfeifer S Scott RT Shah D
Efficacy of an intensive "surgical boot camp" on laparoscopic suturing performance among reproductive endocrinology and infertility (REI) fellows
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation