Infertilidad masculina
El factor masculino es uno de los responsables de los problemas de fertilidad en un 20% de las parejas y contribuye en el 30-40% de casos. Desde hace décadas, el espermiograma ha sido la herramienta clave para determinar la infertilidad masculina, sin embargo, la variabilidad en el recuento de espermatozoides, su movilidad y su morfología forman parte del enigma a la hora de decidir cómo optimizar los tratamientos de reproducción, entre los que se incluye la inseminación artificial y la fecundación in vitro, con o sin el uso de la inyección intracitoplasmática de espermatozoides.
Recientemente, los avances en el campo de la fragmentación de ADN han dado un empuje al estudio de otros parámetros para el análisis de la calidad del semen. Han surgido diversas cuestiones sobre el uso de dispositivos microfluídicos para aislar espermatozoides, así como otros factores epigenéticos que influyen en la calidad del semen y en la descendencia.
Investigadores trabajando en este área
Leer Mas
Públicaciones en este área
- Tachykinins and Kisspeptins in the Regulation of Human Male Fertility.
Blasco V Pinto FM González-Ravina C Santamaría-López E Candenas L Fernández-Sánchez M
J Clin Med. 2019 Dec 31;9(1). pii: E113. doi: 10.3390/jcm9010113. Review.
- Sperm DNA fragmentation on the day of fertilization is not associated with embryologic or clinical outcomes after IVF/ICSI.
Green KA Patounakis G Dougherty MP Werner MD Scott RT Franasiak JM
J Assist Reprod Genet. 2019 Nov 21. doi: 10.1007/s10815-019-01632-5. [Epub ahead of print]
- Effects of lifestyle and certain toxic compounds on the male fertillity
María Jesús Sancho-Velasco Marga Esbert
Medicina Reproductiva y Embriología Clínica, in press, corrected proof, Available online 16 November 2019
- Another step forward toward the identification of sperm function biomarkers with a novel approach evaluating microRNA related pairs.
Garrido N
Fertil Steril. 2019 Nov;112(5):806-807. doi: 10.1016/j.fertnstert.2019.07.1348. No abstract available.
- Donor IUI is equally effective for heterosexual couples, single women and lesbians, but autologous IUI does worse.
Soares SR Cruz M Vergara V Requena A García-Velasco JA
Hum Reprod. 2019 Nov 6. pii: dez179. doi: 10.1093/humrep/dez179. [Epub ahead of print]
- The seminal microbiome in health and disease.
Altmae S Franasiak JM Mandar R
Nat Rev Urol. 2019 Nov 15. doi: 10.1038/s41585-019-0250-y. [Epub ahead of print] Review.
- AUTHOR REPLY.
Tiegs AW
Urology. 2019 Oct;132:116. doi: 10.1016/j.urology.2019.06.040. No abstract available.
- Correction to: ICSI does not offer any benefit over conventional IVF across different ovarian response categories in non-male factor infertility: a European multicenter analysis.
Drakopoulos P Garcia-Velasco JA Bosch E Blockeel C De Vos M Santos-Ribeiro S Makrigiannakis A Tournaye H Polyzos NP
J Assist Reprod Genet. 2019 Oct;36(10):2077-2078. doi: 10.1007/s10815-019-01586-8.
- Total Motile Sperm Count Trend Over Time: Evaluation of Semen Analyses From 119,972 Men From Subfertile Couples.
Tiegs AW Landis J Garrido N Scott RT Jr Hotaling J
Urology. 2019 Jul 18. pii: S0090-4295(19)30642-9. doi: 10.1016/j.urology.2019.06.038. [Epub ahead of print]
- Sperm chromosomal abnormalities and their contribution to human embryo aneuploidy.
Rodrigo L Meseguer M Mateu E Mercader A Peinado V Bori L Campos-Galindo I Milán M García-Herrero S Simón C Rubio C
Biol Reprod. 2019 Jul 18. pii: ioz125. doi: 10.1093/biolre/ioz125. [Epub ahead of print]
Leer Mas
Presentaciones en esta área
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Alegre L Hervas I Viloria T Remohí J Meseguer M P-439 Sperm selection with hyaluronic acid (PICSI) improves efficiency of IVF cycles. Presented at 75th American Society of Reproductive Medicine Scientific Congress
ASRM 2019
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Coello A De los Santos MJ Nohales Corcoles M Meseguer M Remohí J Cobo A
P-107 Impact of fresh blastocyst parameters on survival and implantation in vitrified blastocyst cycles: analysis of 11936 warmed blastocysts.
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Romany L Alegre L Meseguer M
O-12 Effect of sperm selection using MACS technology in the PGT-A program compared with standard sperm preparation
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Bellés M Florensa Bargallo M Esbert M
P-245 DOES MALE AGE AFFECT THE SPERM PARAMETERS AND IVF OUTCOMES?
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Kim G Hanson BM Reig A Neal SA Tiegs AW Osman EK Bergh PA Seli E Scott RT
P-481 THE IMPACT OF IVF ON NEONATAL BIRTHWEIGHT FROM 2000 TO 2017: A DRAMATIC REDUCTION OF LOW BIRTHWEIGHT INFANTS
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Hanson BM Kim G Osman EK Tiegs AW Neal SA Lathi RB Scott RT Franasiak JM
P-264 THE IMPACT OF PATERNAL AGE ON REPRODUCTIVE OUTCOMES IN THE SETTING OF A EUPLOID SINGLE EMBRYO TRANSFER ACHIEVED WITH SURGICALLY EXTRACTED SPERM
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Marin D Zhan Y Scott RT Tao X
P-675 KARYOTYPING SINGLE SPERM: TARGETED NEXT GENERATION SEQUENCING ALLOWS FOR ACCURATE CHROMOSOME COPY NUMBER ANALYSIS OF HAPLOID GENOMES
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Reig A Scott RT Seli E
O-213 THE IMPACT OF AGE BEYOND PLOIDY: OUTCOME DATA FROM 9,101 EUPLOID SINGLE EMBRYO TRANSFERS.
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Pool G Rogers S Mania A Everett G Doshi AM Srikantharajah S Joshi HN Wilding M Bishop S Muriel L Maalouf W Hickman C
P-455 Multi-site, blind prospective trial assessing whether semen oxidation reduction potential (SORP) assessment can be used to predict low fertilisation with conventional IVF: interim analysis
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Soriano MJ Castillo LM Lozoya V Molina I Díaz García C P-056: Post-wash total motile sperm count as the most accurate predictor for live birth after intrauterine insemination Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology
ESHRE 2019
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Margarida E Rodriguez J Wells D Bassas L Loiudice I Casas A Joumady M Guerin A Ballesteros A Fragouli E
P-743: Lack of consistency in the execution and reporting of sperm FISH poses potential problems for clinical interpretation and patient counselling
Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology
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Garrido N
O-223: Finding the best sperm
Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology
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Garrido N Hotaling J Landis J Scott RT Tiegs AW Total motile sperm count trend over time across two continents: evaluation of semen analyses from 119,972 infertile men Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ASRM 2018
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Tiegs W Tao X Landis J Rajchel J Bedard JL Seli E Wells D Fragouli E Scott RT
Evaluation of sperm mitochondrial dna copy number as a predictor of in vitro fertilization/intracytoplasmic sperm injection (ivf/icsi) cycle outcomes in a large infertile population
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Esbert M Soares SR Pacheco A Ballesteros A Florensa M Meseguer M
Human zygotes respond to sperm dna damage by delaying embryonic development
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Selles E Hernandez-Vargas P Garrido N Vilella F Perez-Cano I Muñoz M
Looking for molecular biomarkers of cryodamage in donors semen
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Agudo D
Sperm quality can affect the embryo kinetic and the embryo development
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Staicu FD Martinez-Soto JC Matas C Protein kinase A modulation by nitric oxide during human sperm capacitation Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
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Rivera R Sota N Meseguer M Dominguez F Remohí J Garrido N
Differential sperm proteomic profile between sperm samples achieving pregnancy or not in intracytoplasmic sperm injection (ICSI) cycles in oocyte donation program
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Gianzo M Urizar-Arenaza I Muñoa-Hoyos I Larreategui Z Irazusta J Subiran N
Human sperm aminopeptidase N is related to embryo development and viability during ART
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Rivera Egea R Sota N Meseguer M Dominguez F Remohí J Garrido N
Differential sperm proteomic profile between sperm samples achieving pregnancy or not in intracytoplasmic sperm injection (ICSI) cycles in oocyte donation program
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Esbert M Garrido N Ballesteros A Giménez Sanz A Florensa M
Predictors of positive sperm retrieval in azoospermic
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Alegre L Garrido N Munoz M De los Santos M Remohí J Meseguer M Sperm selection with hyaluronic acid (PICSI) improves LBR in IVF treatments Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2017
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Garcia-Laez V Castello D Gabrielsen A Meseguer M
Clinical validation of a home test kit for semen quality analysis; comparison with gold standard i.e. conventional sperm counting
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Martinez Morales M Meseguer M Perez-Cano I Leon G Gadea B Roldan M Hernandez-Vargas P Galindo N Legidos V Munoz M
Does the seminal cryopreservation influence in embryonic kinetics and clinical results?
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Morin SJ Juneau CR Neal SA Scott RT Hotaling J
Total motile sperm count is negatively correlated with fertilization rate but not blastulation euploidy or implantation in ICSI cycles
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Rivera Egea R Sota N Meseguer M Dominguez F Remohí J Garrido N
Differential sperm proteomic profile between sperm samples achieving pregnancy or not in intracytoplasmic sperm injection (ICSI) cycles in oocyte donation program
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Romany L Rivera Egea R Meseguer M Aparicio-Ruiz B Remohí J Garrido N
Magnetic activated sorting selection (MACS) of non-apoptotic sperm (NAS) improves ongoing pregnancy rates in homologous intrauterine insemination (IUI)
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Dahiya M Bhatia M Egbert S A systematic review and narrative report of the profound psycho-socio-cultural consequences of the growing burden of infertility in developing countries Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017
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Gianzo M Larreategui Z Muñoa-Hoyos I Urizar-Arenaza I Irazusta J Subiran N
The (Pro)renin receptor is expressed in human sperm cells and is related to sperm quality and embryo development
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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González-Ravina C Cruz M Rubio C Fernández-Sánchez M Oquiñena E Ferrando R Requena A
Polymorphic chromosome variants, human inversions, and their functional consequences in male infertility
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Sánchez M Pacheco A Cruz M Requena A
Assessment of sperm ploidy status by flow cytommetry correlates to embryo quality
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology