Desarrollo tecnológico
La tecnología en reproducción asistida ha evolucionado desde el primer recién nacido tras el primer tratamiento de FIV hace ya casi 3 décadas. Mientras que la endocrinología reproductiva y la infertilidad son campos relativamente nuevos, la tecnología en esta área de la medicina ha evolucionado a un ritmo acelerado y lo ha hecho en todas las fases del proceso. En el aspecto clínico, hemos mejorado los sistemas de monitorización de ciclos de FIV, evaluado los índices de masa corporal de las pacientes y analizado el impacto del microbioma, la dieta de los pacientes y su configuración genética. Dentro de los laboratorios de embriología, hemos observado un avance tecnológico que ha mejorado el cultivo embrionario y ha reducido la discrepancia de datos y ha ayudado a eliminar obstáculos para descubrir nuevas patologías.
El análisis de embriones mediante nuevas técnicas que estudian el ADN, el RNA, las proteínas, así como la epigenética, ha contribuido a lograr un mejor conocimiento sobre los mecanismos biológicos del desarrollo embrionario. Estos descubrimientos han originado multitud de cuestiones que se deben resolver.
Investigadores trabajando en este área
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Públicaciones en este área
- When Regenerative Medicine Faces the Challenges of Reproductive Medicine: A Review Study on Recent Advances in the Strategies for Derivation of Gametes from Stem Cells
María Gil Juliá José V Medrano
EMJ Reproductive Health, August 2020
- Novel and conventional embryo parameters as input data for artificial neural networks: an artificial intelligence model applied for prediction of the implantation potential
Bori L Elena Paya Lucia Alegre Thamara Alexandra Viloria Jose Alejandro Remohi Valery Naranjo Meseguer M
Fertility and SterilityIn press, corrected proofAvailable online 8 September 2020
- Registro Nacional de Actividad-Registro de la Sociedad Española de Fertilidad de fecundación in vitro e inyección espermática intracitoplasmática. Años 2016 y 2017.
Cuevas I Prados F Pons I Montserrat de Andrés Sánchez-Castro L Lafuente R de los Santos MJ Herrero J Cabello Y Muñoz P Castel AB Canales M Castilla JA
Medicina Reproductiva y Embriología ClínicaIn press, corrected proofAvailable online 11 March 2020
- Bioengineering strategies of the uterus towards improving current investigative models and female reproductive health.
Campo H Cervelló I pellicer A
Facts Views Vis Obgyn. 2019 Mar;11(1):87-99.
- Influence of Caesarean sectionpregnancy interval on uterine rupture risk and IVF pregnancy rates: systematic review and mathematical modelling
Roberto Matorras Leire Berreteaga Lucía Laínz Antonia Exposito Luis Martinez
Asian J Androl. 2019 Jul 2. doi: 10.4103/aja.aja_58_19. [Epub ahead of print]
- Metabolic imaging with the use of fluorescence lifetime imaging microscopy (FLIM) accurately detects mitochondrial dysfunction in mouse oocytes
Sanchez T Wang T Pedro MV Zhang M Esencan E Sakkas D Needleman D Seli E
Fertil Steril, 110(7):1387-1397. 2018.
- Inter-assay variation and reproducibility of progesterone measurements during ovarian stimulation for IVF.
Lawrenz B Sibal J Garrido N Abu E Jean A Melado L Fatemi HM
PLoS One, 13(11):NA-NA, 2018.
- Pores for thought: preimplantation genetic testing using a nanopore-based DNA sequencer.
Fragouli E Wells D
Fertil Steril, 110(5):853-855, 2018.
- Pancreatic autoimmunity: An unknown etiology on patients with assisted reproductive techniques (ART)-recurrent reproductive failure.
Alecsandru D Barrio A Andia V Cruz E Aparicio P Serna J Cruz M Pellicer A García-Velasco JA
PLoS One, 13(10):NA-NA, 2018.
- Clinical trial registry alone is not adequate: on the perception of possible endpoint switching and P-hacking.
Hill MJ Connell MT Patounakis G
Hum Reprod, 33(2):341-342, 2018.
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Presentaciones en esta área
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Leaver M Kubikova N Tao X Jalas C Wells D O-270 A nobel long-range DNA sequencing approach improves the design of new protocols for preimplantation genetic testing of monogenic disease (PGT-M). Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2020
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Tiegs AW Tao X Whitehead CR Neal SA Osman EK Kim G Hanson BM Seli E Patounakis G Gutmann J Castlebaum A O-74 DOES PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A) HARM EMBRYOS? NO—A MULTI-CENTER, PROSPECTIVE, BLINDED, NON-SELECTION STUDY EVALUATING THE PREDICTIVE VALUE OF AN ANEUPLOID DIAGNOSIS AND IMPACT OF BIOPSY Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2019
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Bayram A De Munck N ElKhatib I Arnanz A El Damen A Abdala A Melado L Lawrenz B Fatemi H P-166: Impact of embryo replacement position (ERP) on euploid frozen embryo transfer (FET) outcomes Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ESHRE 2019
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Supramaniam P Granne I Becker C Lim L.M Venkatakrishnan R Mittal M
O-234: Is ICSI ethically supported by evidence as the method of fertilisation in donor oocyte cycles, in the absence of a medical indication?
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Ferrero H Corachán A Quiñonero A Carbajo-García C Alamá P Tejera A Taboas E Muñoz E Pellicer A Domínguez F NGS of Oocytes from Endometriosis Patients Reveals a Differential Transcriptomic Pattern Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2019
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Gonzalez-Martin R Quiñonero A Pérez S Salsano S Domínguez F
Acute DEHP Exposure in Endometrial Epithelial Cells Does Not Phenocopy the Alterations Described in Endometriosis.
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Gonzalez-Martin R Telez-Plaza M Domínguez F
Association of Blood Cadmium and Lead Levels with Reproductive Lifespan Among Postmenopausal Women: NHANES 2005-2014.
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Sánchez-de-Puerta I González-García M Varela E Mor A
Implications of Telomere Biology in Female Reproductive Aging Using the SAMP8 Mouse Model
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Salsano S Quiñonero A Yañez-Mo Gómez A Pérez S Dominguez F
Novel Non-Classic Progesterone P4 Receptor PGRMC1 Interactions and Functionality Reveal a Key Role
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Duan J Jiang Z Seli E Tian X Wang T Zhang M Evaluating mitochondrial stress response gene clpp-regulated dna methylome dynamics in female reproductive aging Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2018
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Rajchel J Vega C Garnsey HM Scott I Jalas C Tao X Scott RT
Validation of simultaneous diagnosis of single gene disorder (sgd) and next generation sequencing (ngs) - based comprehensive chromosomal aneuploidy screening (ccs) from a single trophectoderm (te) biopsy
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Morin SJ Wang T Tao X Earnhardt M Seli E Scott RT
Ultra-low oxygen (o2) tension after day 3 of in vitro development does not alter blastocyst transcriptome: a comparison of 2% versus 5% o2 tension in extended culture
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Kim G Morin SJ Patounakis G Juneau C Neal SA
Abc trial: appraisal of body content. Frozen embryo cycles are not impacted by the negative effects of obesity seen in fresh cycles
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
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Tiegs W Tao X Landis J Rajchel J Bedard JL Seli E Wells D Fragouli E Scott RT
Evaluation of sperm mitochondrial dna copy number as a predictor of in vitro fertilization/intracytoplasmic sperm injection (ivf/icsi) cycle outcomes in a large infertile population
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
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Castillo LM Buigues A Pellegrini L Rossi V Klinger F Pellicer A Herraiz S LH gonadoprotection against ovarian damage induced by alkytaing drugs in adult mouse ovaries. Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ESHRE 2018
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Devesa A Sebastian-Leon P Garcia-Garcia F Arnau V Pellicer A Diaz-Gimeno P
Functional genomic meta-analysis identifies similarities between endometrial-related subfertilities
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Staicu FD Martinez-Soto JC Matas C
Protein kinase A modulation by nitric oxide during human sperm capacitation
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Salsano S Quiñonero A Pérez S González-Ravina C Simón C Dominguez F
Non-classical progesterone signaling may be sufficient to induce decidualization in Human Endometrial Stromal Cells (ESC)
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Cecchino G Cerrillo M Cruz M Garcia Velasco J
Retrospective analysis of DuoStim cycles shows similar overall performance and oocyte quality between follicular and luteal phase stimulation
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Fatemi H Griesinger G Teal V Polyzos N Bosch E Johnson B Dos Santos S Garcia Velasco J Stoop D
FSH exposure between day 8 and day of Hcg administration is an independent predictor of serum progesterone rise
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Perez S Salsano S Quiñonero A Dominguez F Phytoestrogens (Soy-Derived Metabolites) May Act Like Endometrial Disruptors Altering Decidualization of Human Endometrial Stromal Cells Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2018
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Colombo S Franasiak JM Kaser DJ Molinaro T Bergh PA Significance of endometrial lining decrease after progesterone start in synthetic frozen embryo transfer (FET) cycles Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2017