Desarrollo tecnológico

Áreas de Investigación

La tecnología en reproducción asistida ha evolucionado desde el primer recién nacido tras el primer tratamiento de FIV hace ya casi 3 décadas. Mientras que la endocrinología reproductiva y la infertilidad son campos relativamente nuevos, la tecnología en esta área de la medicina ha evolucionado a un ritmo acelerado y lo ha hecho en todas las fases del proceso. En el aspecto clínico, hemos mejorado los sistemas de monitorización de ciclos de FIV, evaluado los índices de masa corporal de las pacientes y analizado el impacto del microbioma, la dieta de los pacientes y su configuración genética. Dentro de los laboratorios de embriología, hemos observado un avance tecnológico que ha mejorado el cultivo embrionario y ha reducido la discrepancia de datos y ha ayudado a eliminar obstáculos para descubrir nuevas patologías.

El análisis de embriones mediante nuevas técnicas que estudian el ADN, el RNA, las proteínas, así como la epigenética, ha contribuido a lograr un mejor conocimiento sobre los mecanismos biológicos del desarrollo embrionario. Estos descubrimientos han originado multitud de cuestiones que se deben resolver.

Investigadores
trabajando en este área

Cargando datos

Nombre
Richard T Scott, M.D.,H.C.L.D. Founding Partner IVIRMA Global RMA New Jersey
Antonio Pellicer , M.D., Ph.D. Chief Executive Officer for IVIRMA IVI Rome
Emre Seli, M.D. US Research Director RMA New Jersey
Dagan Wells, Ph.D. Oxford Research Director Oxford Basic Research Centre
Elpida Fragouli, MSc, Ph.D. Research Laboratory Director Oxford Basic Research Centre
Jason Franasiak, MD, FACOG, HCLD/ALD (ABB) Chief Medical Officer of IVIRMA America RMA New Jersey
David Agudo Garcillán, Ph.D. Assistant Manager of the IVF Laboratory at the IVI Madrid IVI Madrid
María José De los Santos, Ph.D Director of the Clinical Embryology Laboratory at IVI Valencia IVI Valencia
Evelin Lara, M.D. Director of the Egg Donation Unit at IVI Barcelona IVI Barcelona
Roberto Matorras, M.D., Ph.D. Coordinator for Research and Education at IVI Bilbao IVI Bilbao
Fernando Bronet, Ph.D. Director of the IVF and PGD Laboratories at IVI Madrid IVI Madrid
Marcos Meseguer, Ph.D. Scientific Supervisor and Senior Embryologist at the IVI Valencia IVF unit IVI Valencia
Javier Herrero, MsC. Clinical Embryologist and Project Manager in Medical Affairs IVI Madrid
Irene Rubio Palacios, Ph.D. Clinical Embryologist and Project Manager in Medical Affairs IVI Madrid
José Remohí, Ph.D Founding Partner IVI-RMA Global IVI Valencia

Publicaciones
de esta área

Cargando datos

Nombre
Usability, accuracy, and cost-effectiveness of a medical software for early pregnancies: a retrospective study. Blavier F, Grobet D, Duflos C, Rayssiguier R, Ranisavljevic N, Duport Percier M, Rodriguez A, Blockeel C, Santos-Ribeiro S, Faron G, Gucciardo L, Fuchs F Hum Reprod. 2023 Feb 10:dead025. doi: 10.1093/humrep/dead025. Online ahead of print.. 2023 doi:
Optimization of human semen analysis using CASA-Mot technology. García-Molina A, Navarro N, Valverde A, Sadeghi S, Garrido N, Soler C Syst Biol Reprod Med. 2023 Feb 20:1-9. doi: 10.1080/19396368.2023.2170297. Online ahead of print.. 2023 doi:
Automatic characterization of human embryos at day 4 post-insemination from time-lapse imaging using supervised contrastive learning and inductive transfer learning techniques Elena Payá, Lorena Bori, Adrián Colomer, Marcos Meseguer, Valery Naranjo Computer Methods and Programs in Biomedicine Available online 16 May 2022, 106895. In Press, Journal Pre-proof. 2022 doi:
Fertility technologies and how to optimize laboratory performance to support the shortening of time to birth of a healthy singleton: a Delphi consensus. Coticchio G, Behr B, Campbell A, Meseguer M, Morbeck DE, Pisaturo V, Plancha CE, Sakkas D, Xu Y, D'Hooghe T, Cottell E, Lundin K J Assist Reprod Genet. Feb. 2021 doi: 10.1007/s00192-021-04706-0
vNOTES for adnexal procedures Brandao P, Almeida A, Ramoa P, J Obstet Gynaecol. Apr. 2021 doi: 10.1080/01443615.2020.1841124
When Regenerative Medicine Faces the Challenges of Reproductive Medicine: A Review Study on Recent Advances in the Strategies for Derivation of Gametes from Stem Cells Maria Gil Julia, Jose V Medrano, EMJ Reproductive Health. 2020 doi:
Current Controversies in Prenatal Diagnosis 3: Gene editing should replace embryo selection following PGD Wells D, Vermeesch J R, Simpson J L, Prenat Diagn. Apr. 2019 doi: 10.1002/pd.5442
Detection of segmental aneuploidy and mosaicism in the human preimplantation embryo: technical considerations and limitations. Treff N, Franasiak J M, Fertil Steril. 2017 doi:
Genome editing reveals a role for OCT4 in human embryogenesis. Fogarty N, McCarthy A, Snijders KE, Powell BE, Kubikova N, Blakeley P, Lea R, Elder K, Wamaitha S, Daesik K, Maciulyte V, Kleinjung J, Kim J, Wells D, Vallier L, Bertero A, Turner J, Elder K, Nature. 2017 doi:
Mitochondrial DNA quantification as a tool for embryo viability assessment: retrospective analysis of data from single euploid blastocyst transfers. Ravichandran K, McCaffrey C, Grifo J, Morales A, Perloe M, Munne S, Wells D, Fragouli E, Hum Reprod. 2017 doi:
Detection of Missing Proteins Using the PRIDE Database as a Source of Mass Spectrometry Evidence Garin-Muga A, Odriozola L, Martinez-Val A, Del Toro N, Martinez R, Molina M, Cantero L, Rivera R, Garrido N, Dominguez F, Sanchez Del Pino M M, Vizcaino J A, Corrales F J, Segura V, J Proteome Res. 4-Nov. 2016 doi: 10.1021/acs.jproteome.6b00437
Pathophysiologic processes have an impact on the plasma metabolomic signature of endometriosis patients Vicente-Munoz S, Morcillo I, Puchades-Carrasco L, Paya V, Pellicer A, Pineda-Lucena A, Fertil Steril. Dec. 2016 doi: 10.1016/j.fertnstert.2016.09.014
Spermatozoa from infertile patients exhibit differences of DNA methylation associated with spermatogenesis-related processes: an array-based analysis Camprubi C, Salas-Huetos A, Aiese-Cigliano R, Godo A, Pons M C, Castellano G, Grossmann M, Sanseverino W, Martin-Subero J I, Garrido N, Blanco J, Reprod Biomed Online. Dec. 2016 doi: 10.1016/j.rbmo.2016.09.001
The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists Sermon K, Capalbo A, Cohen J, Coonen E, De Rycke M, De Vos A, Delhanty J, Fiorentino F, Gleicher N, Griesinger G, Grifo J, Handyside A, Harper J, Kokkali G, Mastenbroek S, Meldrum D, Meseguer M, Montag M, Munne S, Rienzi L, Rubio C, Scott K, Scott R T, Simon C, Swain J, Treff N, Ubaldi F, Vassena R, Vermeesch J R, Verpoest W, Wells D, Geraedts J, Mol Hum Reprod. Aug. 2016 doi: 10.1093/molehr/gaw034
Ovarian stimulation, insemination, and contraception Galliano D, Fertil Steril. Mar. 2016 doi: 10.1016/j.fertnstert.2015.12.025
Evaluation of the antiproliferative, proapoptotic, and antiangiogenic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of leiomyoma Garcia-Pascual C M, Ferrero H, Juarez I, Martinez J, Villanueva A, Pozuelo-Rubio M, Soengas M, Tormo D, Simon C, Gomez R, Pellicer A, Fertil Steril. Feb. 2016 doi: 10.1016/j.fertnstert.2015.10.037
A randomized and blinded comparison of qpcr and NGS based detection of aneuploidy in a cell line mixture model of blastocyst biopsy mosaicism. Goodrich D, Tao X, Bohrer C, Lonczak A, Xing T, Zimmerman R, Zhan Y, Scott R T, Treff NR, Scott R T, Hum Reprod. 2016 doi:
Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy. Ravichandran K, Guzman L, Escudero T, Zheng X, Colls P, Jordan A, Cohen J, Wells D, Munne S, Wells D, RBM Online. 2016 doi:
Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios. Agarwal A, Majzoub A, Esteves SC, Ko E, Ramasamy R, Zini A, Transl Androl Urol. 2016 doi:
Current controversies in prenatal diagnosis 4: preimplantation genetic screening should be routinely offered to all preimplantation genetic diagnosis cases. Harper J, Wells D, Simpson JL, Prenat Diagn. 2016 doi:
Decreased fecundity and sperm DNA methylation patterns. Jenkins TG, Aston KI, Meyer TD, Hotaling J M, Shamsi MB, Johnstone EB, Cox KJ, Stanford JB, Porucznik CA, Carrell DT, Fertil Steril. 2016 doi:
Development and validation of concurrent preimplantation genetic diagnosis for single gene disorders and comprehensive chromosomal aneuploidy screening without whole-genome amplification. Zimmerman RS, Jalas C, Tao X, Fedick AM, Kim J, Pepe RJ, Northrop LE, Scott R T, Treff NR , Scott R T, Fertil Steril. 2016 doi:
Drug gastrointestinal absorption in rat: Strain and gender differences. Oltra D, Mangas-Sanjuan V, Gonzalez-Alvarez I, Colon-Useche S, Gonzalez-Alvarez M, Bermejo M, Eur J Pharm Sci. 2016 doi:
Effect of surgery on ovarian reserve in women with endometriomas, endometriosis and controls. Goodman L, Goldberg J, Flyckt RL, Gupta M, Harwalkar J, Falcone T, Am J Obstet Gynecol. 2016 doi:
Expanded carrier screening in an infertile population: how often is clinical decision making affected? Franasiak J M, Olcha M, Bergh PA, Hong KH, Forman EJ, Werner M D, Genet Med Off J Am Coll Med Genet. 2016 doi:
First validated clinical test selects best embryos for IVF and viable pregnancies. Fragouli E, MLO Med Lab Obs. 2016 doi:
Frozen-thawed embryo transfers in natural cycles with spontaneous or induced ovulation: the search for the best protocol continues Montagut M, Santos-Ribeiro S, De Vos M, Polyzos NP, Drakopoulos P, Mackens S, van de Vijver A, Verheyen G, Tournaye H, Blockeel C, Hum Reprod. 2016 doi:
Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations Varela E, Muñoz M, Tejera M, Ortega I, Blasco M, Nature Communications. 2016 doi:
Hormone-Based Treatments in Subfertile Males. Review. Patel DP, Chandrapal JC, Hotaling J M, Curr Urol Rep. 2016 doi:
Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality. Cariati F, Jaroudi S, Alfarawati S, Raberi A, Alviggi C, Pivonello R, Wells D, RBM Online. 2016 doi:
IVF: progress through Technology development . Garcia-Velasco J A, Seli E, Curr Opin Obstet Gynecol. 2016 doi:
Microfluidics: The future of microdissection TESE? Samuel R, Badamjav O, Murphy KE, Patel DP, Son J, Gale BK, Carrell DT, Hotaling J M, Syst Biol Reprod Med. 2016 doi:
Mitochondrial DNA as a biomarker for in vitro fertilization (IVF) outcome Seli E, Curr Opin Obstet Gynecol. 2016 doi:
Mosaicism: “survival of the fittest” versus “no embryo left behind”. Munne S, Grifo J, Wells D, Fertil Steril. 2016 doi:
Multiple thrombophilic single nucleotide polymorphisms lack a significant effect on outcomes in fresh IVF cycles: an analysis of 1717 patients. Patounakis G, Bergh E, Forman E, Tao X, Lonczak A, Franasiak J M, Treff N, Scott R T, J Assist Reprod Genet. 2016 doi:
Next Generation Sequencing Based Comprehensive Chromosome Screening in Mouse Polar Bodies, Oocytes, and Embryos. Treff NR, Krisher R, Tao X, Garnsey H, Bohrer C, Silva E, Landis J, Taylor D, Scott R T, Woodruff TK, Duncan FE, Taylor D, Biol Reprod. 2016 doi:
Optimization of microelectrophoresis to select highly negatively charged sperm. Simon L, Murphy K, Aston KI, Emery BR, Hotaling J M, Carrell DT, J Assist Reprod Genet. 2016 doi:
Predictors of sperm recovery after cryopreservation in testicular cancer. Hotaling J M, Patel DP, Vendryes C, Lopushnyan NA, Presson AP, Zhang C, Muller CH, Walsh TJ, Asian J Androl. 2016 doi:
Preimplantation genetic diagnosis for infertility. Wells D, Lewin J, Textbook of Assisted Reproductive technologies. 2016 doi:
Preimplantation genetic diagnosis: an overview and recent advances. Ben-Nagi J, Serhal P, SenGupta S, Doye K, Wells D, Obstet Gynaecol. 2016 doi:
Same-sex reproduction:Medical treatment options and psychosocial considerations. Greenfeld D, Seli E, 2016 doi:
SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts. Treff NR, Thompson K, Rafizadeh M, Chow M, Morrison L, Tao X, Garnsey H, Reda CV, Metzgar TL, Neal S, Jalas C, Scott R T, Forman E, Reda CV, J Assist Reprod Genet. 2016 doi:
Técnicas invasivas y no invasivas en el diagnóstico de embriones humanos. Calomarde C, Carmona L, Guerra I, Gutierrez D, Santana A, Domingo J, Rev Iberoam Fert Rep Hum. 2016 doi:
Teratozoospermia and asthenozoospermia are associated with specific epigenetic signatures. Jenkins TG, Aston KI, Hotaling J M, Shamsi MB, Simon L, Carrell DT, Andrology. 2016 doi:
Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease. Hyslop LA, Blakeley P, Craven L, Richardson J, Fogarty NM, Fragouli E, Lamb M, Wamaitha SE, Prathalingam N, Zhang Q, O'Keefe H, Takeda Y, Arizzi L, Alfarawati S, Tuppen HA, Irving L, Kalleas D, Wamaitha SE, Wells D, Murdoch AP, Turnbull DM, Niakan KK, Herbert M, Nature. 2016 doi:
Why do euploid embryos miscarry? A case-control study comparing the rate of aneuploidy within presumed euploid embryos that resulted in miscarriage or live birth using next-generation sequencing. Maxwell SM, Colls P, Hodes-Wertz B, McCulloh DH, McCaffrey C, Wells D, Munne S, Grifo J, Fertil Steril. 2016 doi:
New strategy for diagnosing embryo implantation potential by combining proteomics and time-lapse technologies Dominguez F, Meseguer M, Aparicio-Ruiz B, Piqueras P, Quinonero A, Simon C, Fertil Steril. Oct. 2015 doi: 10.1016/j.fertnstert.2015.06.032
Ongoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels Requena A, Cruz M, Pacheco A, Garcia-Velasco J A, Fertil Steril. Oct. 2015 doi: 10.1016/j.fertnstert.2015.06.026
What does morphokinetics add to embryo selection and in-vitro fertilization outcomes? Basile N, Caiazzo M, Meseguer M, Curr Opin Obstet Gynecol. Jun. 2015 doi: 10.1097/GCO.0000000000000166
The use of morphokinetics as a predictor of implantation: a multicentric study to define and validate an algorithm for embryo selection Basile N, Vime P, Florensa M, Aparicio Ruiz B, Garcia-Velasco J A, Remohi J, Meseguer M, Hum Reprod. Feb. 2015 doi: 10.1093/humrep/deu331
24-chromosome PCR for aneuploidy screening. Werner M D, Scott R T, Curr Opin Obstet Gynecol. 2015 doi:
Endometriosis and ascites, a strategy to achieve pregnancy. Sidiropoulou Z, Setúbal A, Barbosa C, Soares S R, J Min Inv Gynecol. 2015 doi:
Introducing Larger Equipment: A Novel Method in Laparoscopic Surgery with Smaller Port Sites. Kim S, Goodman L, Goldberg J, J Minim Invasive Gynecol. 2015 doi:
Karyomapping allows preimplantation genetic diagnosis of a de-novo deletion undetectable using conventional PGD technology. Gimenez C, Sarasa J, Arjona C, Vilamajo E, Martinez-Pasarell O, Wheeler K, Valls G, Garcia-Guixe E, Wells D, Garcia-Guixe E, RBM Online. 2015 doi:
La tecnología del Time-lapse y su aplicación en las clínicas de reproducción asistida. Meseguer M, Motato M, ASEBIR. 2015 doi:
Micro-electrophoresis: a noninvasive method of sperm selection based on membrane charge. Simon L, Murphy K, Aston K, Emery B, Hotaling J M, Carrell D, Fertil Steril. 2015 doi:
Ovarian ageing Seli E, Semin Reprod Med. 2015 doi:
Routine use of next-generation sequencing for preimplantation genetic diagnosis of blastomeres obtained from embryos on day 3 in fresh in~vitro fertilization cycles. Ukaszuk K, Pukszta S, Wells D, Cybulska C, Liss J, P?ociennik ?, Kuczy?ski W, Zabielska J, Fertil Steril. 2015 doi:
s endometrial receptivity transcriptomics affected in women with endometriosis? A pilot study. Garcia-Velasco J A, Fassbender A, Ruiz Alonso M, Blesa D, D'Hooghe T, Simon C, RBM Online. 2015 doi:
Targeted Germline Modifications in Rats Using CRISPR/Cas9 and Spermatogonial Stem Cells. Chapman K, Medrano G, Jaichander P, Chaudhary, Waits A, Nobrega M, Hotaling J M, Ober C, Hamra F, Ober C, Cell Rep. 2015 doi:
The use of morphokinetics as a predictor of implantation: a multicentric study to define and validate an algorithm for embryo selection. Basile N, Vime P, Florensa M, Aparicio Ruiz B, Garcia-Velasco J A, Remohi J, Meseguer M, Hum Reprod. 2015 doi:
Time-Lapse in the IVL lab: how should we assess potential benefit Basile N, Barrière P, Meseguer M, Freour T, Hum Reprod. 2015 doi:
Validation of next-generation sequencing for comprehensive chromosome screening of embryos. Kung A, Munne S, Bankowski B, Coates A, Wells D, RBM Online. 2015 doi:
Variability of permeability estimation from different protocols of subculture and transport experiments in cell monolayers. Oltra D, Mangas-Sanjuan V, Centelles-Sangüesa A, Gonzalez-Garcia I, Sanchez-Castaño G, Gonzalez-Alvarez M, Casabo VG, Merino V, Gonzalez-Alvarez I, Bermejo M, J Pharmacol Toxicol Methods. 2015 doi:
Analysis of embryo morphokinetics, multinucleation and cleavage anomalies using continuous time-lapse monitoring in blastocyst transfer cycles. Desai N, Ploskonka S, Goodman L, Austin C, Goldberg JM, Falcone T, Reprod Biol Endocrinol 2014 Jun 20;12(1):54. 2014 doi:
Clinical genetic testing for male factor infertility: current applications and future directions. Hotaling J M, Carrell DT, Andrology. 2014 doi:
Clinical utilization of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation. Wells D, Kaur K, Grifo J, Glassner M, Taylor JC, Fragouli E, Munne S, J Med Genet. 2014 doi:
Comparison of array comparative genomic hybridization and quantitative real-time PCR-based aneuploidy screening of blastocyst biopsies. Capalbo A, Treff N, Cimadomo D, Tao X, Upham K, Ubaldi F, Rienzi L, Scott R T, Eur J Hum Genet. 2014 doi:
Comprehensive chromosome screening (CCS) with synchronous blastocyst transfer: Time for a paradigm shift. Scott R T, Franasiak J M, Forman E, Fertil Steril. 2014 doi:
Genome-wide karyomapping accurately identifies the inheritance of single-gene defects in human preimplantation embryos in vitro. Natesan SA, Bladon AJ, Coskun S, Qubbaj W, Prates R, Munne S, Coonen E, Dreesen JC, Stevens SJ, Paulussen AD, Stock-Myer SE, Wilton LJ, Jaroudi S, Wells D, Brown AP, Handyside AH Dreesen JC, Genet Med. 2014 doi:
Live birth after PGD with confirmation by a comprehensive approach (karyomapping) for simultaneous detection of monogenic and chromosomal disorders. Natesan SA, Handyside AH, Thornhill AR, Ottolini CS, Sage K, Summers MC, Konstantinidis M, Wells D, Griffin DK, RBM Online. 2014 doi:
Metabolomic prediction of pregnancy viability in superovulated cattle embryos and recipients with fourier transform infrared spectroscopy Muñoz M, Uyar A, Correia E, Ponsart C, Guyader-Joly C, Martinez-Bello D, Marquant-Le Guienne B, Fernandez-Gonzalez A, Diez C, Caamaño JN, Trigal B, Humblot P, Carrocera S, Martin D, Seli E, Gomez E, Biomed Res Int. 2014 doi:
Next-generation sequencing: the dawn of a new era for preimplantation genetic diagnostics. Wells D, Fertil Steril. 2014 doi:
Non-invasive prediction of embryonic sex in cattle by metabolomic analysis of in vitro culture medium with Fourier transfrom infrared spectroscopy. Muñoz M, Uyar A, Correia E, Diez C, Fernandez A, Caamaño JN, Trigal B, Carrocera S, Seli E, Gomez E, Metabolomics. 2014 doi:
Non-invasive techniques: Embryo selection by transcriptomics, proteomics and metabolomics. Uyar A, Seli E, 2014 doi:
OMICS- current and future perspectives in reproductive medicine and technology. Rivera R, Garrido N, Sota N, Varghese A, Journal of Human Reproductive Sciences. 2014 doi:
Simple circumcision device: proof of concept for a single-visit, adjustable device to facilitate safe adult male circumcision. Kadlec AO, Ohlander S, Hotaling J M, Hannick J, Niederberger C, Turk TM, Urolithiasis. 2014 doi:
Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform. Konstantinidis M, Alfarawati S, Hurd D, Paolucci M, Shovelton J, Fragouli E, Wells D, Fertil Steril. 2014 doi:
False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3 Mir P, Rodrigo L, Mercader A, Buendia P, Mateu E, Milan-Sanchez M, Peinado V, Pellicer A, Remohi J, Simon C, Rubio C, J Assist Reprod Genet. Jan. 2013 doi: 10.1007/s10815-012-9918-4
Assessment of sperm using mRNA microarray technology. Garrido N, Garcia-Herrero S, Meseguer M, Fertil Steril. 2013 doi:
Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases IVF implantation and delivery rates: a randomized controlled trial. Scott R T, Ferry KM, Forman EJ, Hong KH, Scott KL, Taylor D, Tao X, Treff NR, Fertil Steril. 2013 doi:
Cleavage stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial. Scott R T, Ferry KM, Forman EJ, Zhao T, Treff NR, Fertil Steril. 2013 doi:
Comprehensive chromosome screening alters traditional morphology-based embryo selection: a prospective study of 100 consecutive cycles of planned fresh euploid blastocyst transfer. Forman EJ, Upham KM, Cheng MZ, Zhao T, Hong KH, Treff NR, Scott R T, Fertil Steril. 2013 doi:
Ergonomic deficits in robotic gynecologic oncology surgery: A need for intervention. Craven R, Franasiak J M, Mosaly P, Gehrig PA, J Minim Invasive Gynecol. 2013 doi:
Evaluation of targeted next-generation sequencing based preimplantation genetic diagnosis of monogenic disease. Treff NR, Fedick A, Tao X, Devkota B, Taylor D, Scott R T, Fertil Steril. 2013 doi:
Four-hour quantitative real-time polymerase chain reaction– based comprehensive chromosome screening and accumulating evidence of accuracy, safety predictive values and clinical efficacy. Treff NR, Scott R T, Fertil Steril. 2013 doi:
Gamete and embryo assessment in assisted reproduction: emerging technologies Gardner D, Sakkas D, Seli E, Wells D, 2013 doi:
High-density SNP arrays and next generation sequencing for pre-implantation genetic diagnosis. Handyside A, Wells D, Gamete and embryo assessment in assisted reproduction: emerging technologies. 2013 doi:
Incidental identification of balanced translocation carrier patients through comprehensive chromosome screening of IVF-derived blastocysts. Treff NR, Forman EJ, Katz-Jaffe MG, Schoolcraft WB, Levy B, Scott R T, J Assist Reprod Genet. 2013 doi:
Metabolomic profiling of oocytes and embryos using spectroscopy: potential clinical use and pitfalls. Sakkas D, Seli E, 2013 doi:
mRNA-binding protein ZFP36 is expressed in atherosclerotic lesions and reduces inflammation in human aortic endothelial cells. Zhang H, Taylor WR, Joseph G, Sidell N, Seli E, Kallen CB, Arterioscl Thromb Vasc Biol. 2013 doi:
Next-generation sequencing for preimplantation genetic diagnosis. Letter to the Editor. Treff NR, Forman EJ, Scott R T, Fertil Steril. 2013 doi:
Regulation of gene expression in the oocyte and early embryo: implications for transcriptomic and proteomic embryo assessment. Kristiansson H, Seli E, 2013 doi:
Selection of high potential embryos using time-lapse imaging: the era of morphokinetics. Herrero J, Meseguer M, Fertil Steril. 2013 doi:
The Paradigm of Clinical IVF is shifting: The Time to Incorporate Validated Technologies and an Enhanced Understanding of Physiology is now. Hong KH, Scott R T, J Clin Embryology. 2013 doi:
The Textbook of Clinical Embryology Coward, Wells D, 2013 doi:
Transcriptomic analysis of cumulus and granulosa cells as a marker of embryo viability. Fragouli E, Wells D, Gamete and embryo assessment in assisted reproduction: emerging technologies. 2013 doi:
Validity and reliability of a smartphone application for the assessment of penile deformity in Peyronie's disease. Hsi RS, Hotaling J M, Hartzler AL, Holt SK, Walsh TJ, J Sex Med. 2013 doi:
Hepatitis B virus in human oocytes and embryos Garrido N, Bellver J, Rubio C, Pellicer A, Hum Reprod. Apr. 2012 doi: 10.1093/humrep/des024
Advances in ovarian hyperstimulation in cancer patients. Domingo J, Guillen V, Martinez M, Rabadan S, Pellicer A, Garcia-Velasco J A, US Obstetrics & Gynecology. 2012 doi:
Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study. Scott R T, Ferry KM, Su J, Tao X, Scott KL, Treff NR, Fertil Steril. 2012 doi:
Development and validation of an accurate quantitative real-time polymerase chain reaction – based assay for human blastocyst comprehensive chromosomal aneuploidy screening. Seminal Contribution. Treff NR, Tao X, Ferry KM, Su J, Taylor D, Scott R T, Fertil Steril. 2012 doi:
Development of a novel synthetic oligopeptide for the detection of DNA damage in human spermatozoa. Enciso M, Pieczenik G, Cohen J, Wells D, Hum Reprod. 2012 doi:
Efficient Use of Early Obstetric Sonography in the Emergency Department Setting. Goodman L, Eichelberger KY, Wolfe H, Steiner AZ, J Ultrasound Med. 2012 doi:
El futuro de la reproducción son los incubadores con un sistema de time-lapse? Tejera A, Meseguer M, ASEBIR. 2012 doi:
Hepatitis B virus in human oocytes and embryos. Garrido N, Bellver J, Rubio C, Pellicer A, Hum Reprod. 2012 doi:
Methods for comprehensive chromosome screening of oocytes and embryos: capabilities, limitations, and evidence of validity. Scott R T, J Assist Reprod Genet. 2012 doi:
Microarray-CGH for the Assessment of Aneuploidy in Human Polar Bodies and Oocytes. Jaroudi S, Wells D, Methods in Molecular Biology. 2012 doi:
PGD and aneuploidy screening for 24 chromosomes by genome-wide SNP analysis: a responsible path towards greater utility. Bisignano A, Wells D, Harton G, Munne S, RBM Online. 2012 doi:
The mRNA-binding protein Zfp36 is up-regulated by b-adrenergic stimulation and represses IL-6 production in 3T3-L1 adipocytes. Brahma PK, Murray BS, Shu F, Sidell N, Seli E, Kallen CB, Obesity. 2012 doi:
Time-lapse technology: evaluation of embryo quality and new markers for embryo selection. Basile N, Meseguer M, Expert Rev Obstet Gynecol. 2012 doi:
Female overweight is not associated with a higher embryo euploidy rate in first trimester miscarriages karyotyped by hysteroembryoscopy Bellver J, Cruz F, Martinez M C, Ferro J, Ramirez J F, Pellicer A, Garrido N, Fertil Steril. Oct. 2011 doi: 10.1016/j.fertnstert.2011.07.003
Aplicación de la tecnología del embryoscope para la cuentificación de la calidad ovocitaria mediante el análisis de los patrones de respiración. Herrero J, Tejera A, Cruz M, Meseguer M, ASEBIR. 2011 doi:
Cinematografía para el estudio de la calidad embrionaria. Embryoscope Herrero J, Tejera A, Cruz M, Meseguer M, ASEBIR. 2011 doi:
How to improve IVF success rates and increase access to treatment: back to basics or more technology? Wells D, Expert Rev Obstet Gynecol. 2011 doi:
Therapeutic treatments of mtDNA diseases at the earliest stages of human development. Chiaratti MR, Meirelles FV, Wells D, Poulton J, Mitochondrion. 2011 doi:
Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos. Gutierrez-Mateo C, Colls P, Sanchez-Garcia J, Escudero T, Prates R, Ketterson K, Wells D, Munne S, Fertil Steril. 2011 doi:
Accurate single cell 24 chromosome aneuploidy screening using whole genome amplification and single nucleotide polymorphism microarrays. Treff NR, Su J, Tao X, Levy B, Scott R T, Fertil Steril. 2010 doi:
Assessing the reproductive competence of individual embryos: a proposal for the validation of new "-omics" technologies. Scott R T, Treff NR, Fertil Steril. 2010 doi:
Improved detection of aneuploid blastocysts using a new 12-chromosome FISH test. Munne S, Fragouli E, Colls P, Katz-Jaffe MG, Schoolcraft WB, Wells D, RBM Online. 2010 doi:
Improving FISH diagnosis for preimplantation genetic aneploidy screening Mir P, Rodrigo L, Mateu E, Milan M, Mercader A, Buendia P, Delgado A, Pellicer A, Remohi J, Rubio C, Hum Reprod. 2010 doi:
Mitotic expression of Spo13 alters M-phase progression and nucleolar localization of Cdc14 in budding yeast. Varela E, Schlecht U, Moina A, Fackenthal JD, Washburn BK, Niederhauser-Wiederkehr C, Tsai-Pflugfelder M, Primig M, Gasser SM, Esposito RE, Genetics. 2010 doi:
OMICS in assisted reproduction: possibilities and pitfalls. Seli E, Robert C, Sirard M-A, Mol Hum Reprod. 2010 doi:
Pregnancy rates alter incubation in new time-lapse incubator (embryoscope) providing detailed information about embryo development compared to incubation in a standard incubator Meseguer M, Hilligsøe KM, Pedersen KS, Herrero J, Tejera A, Garrido N, Fertil Steril. 2010 doi:
Robust embryo identification using polar body single nucleotide polymorphism microarray based DNA fingerprinting. Treff NR, Su J, Kasabwala N, Tao X, Miller KA, Scott R T, Fertil Steril. 2010 doi:
Single Cell Whole Genome Amplification Technique Impacts the Accuracy of SNP Microarray Based Genotyping and Copy Number Analyses. Treff NR, Su J, Tao X, Northrop L, Scott R T, Mol Hum Reprod. 2010 doi:
SNP microarray based 24 chromosome aneuploidy screening demonstrates that cleavage stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts. Northrop L, Treff NR, Levy B, Scott R T, Mol Hum Reprod. 2010 doi:
SNP microarray based 24 chromosome aneuploidy screening is significantly more consistent than FISH. Treff NR, Levy B, Su J, Northrop L, Tao X, Scott R T, Mol Hum Reprod. 2010 doi:
Surgical management of tubal disease and infertility Coughlan C, TC Li, Obstetrics. 2010 doi:
Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes. Munne S, Wells D, Cohen J, Fertil Steril. 2010 doi:
Visualizing yeast chromosomes and nuclear architecture. Meister P, Gehlen LR, Varela E, Kalck V, Gasser SM, Methods in Enzymology. 2010 doi:
14-gauge angiocatheter: the assist port. Hotaling J M, Shear S, Lendvay TS, J Laparoendosc Adv Surg Tech A. 2009 doi:
Computerized analysis of normal fetal heart rate pattern throughout gestation. Serra V, Bellver J, Moulden M, Redman CW, Ultrasound Obstet Gynecol. 2009 doi:
Lte1, Cdc14 and MEN-controlled Cdk inactivation in yeast coordinate rDNA decompaction with late telophase progression. Varela E, Shimada K, Laroche T, Leroy D, Gasser SM, EMBO J. 2009 doi:
Nuevos métodos de selección embrionaria: una nueva tendencia para transferencias únicas. Herrero J, Tejera A, De Los Santos MJ, Garrido N, Ramsing N, Meseguer M, Revista Iberoamericana de Fertilidad y Reproducción Humana. 2009 doi:
Situación Actual de las técnicas de preservación de la Fertilidad. Guillen V, Domingo S, Ayllon Y, Domingo J, Garcia JA, Cuadernos de Medicina Reproductiva. 2009 doi:
TGF-beta regulates expression of transcription factor KLF6 and its splice variants, and promotes co-operative transactivation of common target genes through a Smad3/Sp1/KLF6 interaction. Botella LM, Sanz-Rodriguez F, Komi Y, Fernandez-L A, Varela E, Garrido-Martin EM, Narla G, Friedman SL, Kojima S, Friedman SL, Biochem J. 2009 doi:
Human immunodeficiency type-1 virus (HIV-1) infection in serodiscordant couples (SDCs) does not have an impact on embryo quality or intracytoplasmic sperm injection (ICSI) outcome Melo M A, Meseguer M, Bellver J, Remohi J, Pellicer A, Garrido N, Fertil Steril. Jan. 2008 doi: 10.1016/j.fertnstert.2007.02.004
Alternative splicing of the mouse embryonic poly(A) binding protein (ePAB) RNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte. Seli E, Yaba A, Guzeloglu-Kayisli O, Lalioti MD, Mol Hum Reprod. 2008 doi:
Evaluation of embryo quality by Metabolomics: A new strategy to aid single embryo transfer. Sakkas D, Morita H, Yamashita N, Kato LO, Botros L, Roos P, Seli E, J Mammal Ova Res. 2008 doi:
Functional localization of DNA damage to pore complex bound to Slx5/8 SUMO-dependent E3 ligase Nagai S, Dubrana K, Tsai-Pflufelder M, Davidson M, Roberts T, Brown G, Varela E, Hediger F, Gasser SM, Krogan NJHediger F, Science. 2008 doi:
Identification and characterization of human embryonic poly(A) binding protein (ePAB). Guzeloglu-Kayisli O, Pauli SA, Demir H, Lalioti MD, Sakkas D, Seli E, Mol Hum Reprod. 2008 doi:
Non-invasive metabolomic profiling of embryo culture media using proton NMR correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Seli E, Botros L, Sakkas D, Burns DH, Fertil Steril. 2008 doi:
Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot Scott R T, Seli E, Miller K, Sakkas D, Scott K, Burns DH, Fertil Steril. 2008 doi:
Unique pharmacology of KAR-2, a potential anti-cancer agent: absorption modeling and selective mitotic spindle targeting. Gonzalez-Alvarez I, Gonzalez-Alvarez M, Oltra D, Merino V, Tõkesi N, Ovadi J, Bermejo M, Eur J Pharm Sci. 2008 doi:
Use of comprehensive chromosomal screening for embryo assessment: microarrays and CGH. Wells D, Alfarawati S, Fragouli E, Mol Hum Reprod. 2008 doi:
Future genetic and other technologies for assessing embryos. Wells D, Handbook of Embryo Evaluation. 2007 doi:
Non-Invasive metabolomic profiling of human embryo culture media using Raman and near infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Seli E, Sakkas D, Scott R T, Kwok JS, Rosendahl S, Burns DH, Fertil Steril. 2007 doi:
Examination of the fetal brain by transabdominal three-dimensional ultrasound: potential for routine neurosonographic studies Correa F F, Lara C, Bellver J, Remohi J, Pellicer A, Serra V, Ultrasound Obstet Gynecol. May. 2006 doi: 10.1002/uog.2750
Active CMOS array sensor for time-resolved fluorescence detection. Patounakis G, Shepard KL, Levicky R, IEEE J Solid-State Circuits. 2006 doi:
Crossmodal audio-visual interactions in the primary visual cortex of the visually deprived cat: a physiological and anatomical study. Sanchez-Vives MV, Nowak LG, Descalzo VF, Garcia-Velasco J A, Gallego R, Berbel P, Prog Brain Res. 2006 doi:
Pulse current-mode signalling for nearly speed-of-light intrachip communcations Jose AP, Patounakis G, Shepard KL, IEEE J Solid-State Circuits. 2006 doi:
Use of Real-Time Polymerase Chain Reaction to Measure Gene Expression in Single Cells. Wells D, Single Cell Diagnostics: Methods and Protocols. 2006 doi:
An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos. Seli E, Lalioti MD, Flaherty SM, Sakkas D, Terzi N, Steitz JA, Proc Natl Acad Sci USA. 2005 doi:
E-learning in reproductive medicine. Garcia-Velasco J A, Schneider J, Hum Reprod. 2005 doi:
Near Speed-of-Light On-Chip Interconnects Using Pulsed Current-Mode Signaling. Jose AP, Patounakis G, Shepard KL, 2005 Symposium on VLSI Circuits. 2005 doi:
A Fully Integrated On-Chip DC-DC Conversion and Power Management System. Patounakis G, Li YW, Shepard KL, IEEE J Solid-State Circuits. 2004 doi:
A new follicle aspiration set is equally effective and as well tolerated as the standard needle when used in a prospective randomized trial in a large in vitro fertilization program. Miller KA, Elkind-Hirsch K, Benson M, Bergh P, Drews M, Scott R T, Fertil Steril. 2004 doi:
A proteomic approach to study Salmonella typhi periplasmic proteins altered by a lack of the DsbA thiol: disulfide isomerase. Agudo D, Mendoza MT, Castañares C, Nombela C, Rotger R, Proteomics. 2004 doi:
Expression profiles of individual human oocytes using microarray technology. Bermúdez MG, Wells D, Malter H, Munne S, Cohen J, Steuerwald NM, RBM Online. 2004 doi:
High-throughput asynchronous datapath with software-controlled voltage scaling. Li YW, Patounakis G, Shepard KL, Nowick SM, IEEE J Solid-State Circuits. 2004 doi:
Isolation and characterization of two families of satellite DNA with repetitive units of 135 bp and 2.5 Kb in the ant Monomorium subopacum Hymenoptera, Formicidae). Lorite P, Aguilar J, Carrillo J, Palomeque T, Cytogenet Genome Res. 2004 doi:
Microarrays for Analysis and Diagnosis of Human Embryos Wells D, Bermudez MG, Steuerwald N, Chu L, Weier U, Cohen J, Munne S, Fertil Steril. 2004 doi:
Uterine and ovarian function in endometriosis Garrido N, Pellicer A, Remohi J, Simon C, Semin Reprod Med. May. 2003 doi: 10.1055/s-2003-41325
Asynchronous datapath with software-controlled on-chip adaptive voltage scaling for multirate signal processing applications. Li YW, Patounakis G, Jose AP, Shepard KL, 2003 IEEE International Symposium on Asynchronous Circuits and Systems. 2003 doi:
Cytogenetics in reproductive medicine: The contribution of comparative genomic hybridization (CGH). Wells D, Levy B, BioEssays. 2003 doi:
Whole genome amplification and comparative genomic hybridization (CGH). Wells D, Bermudez M, PCR Technology: Current Innovations. 2003 doi:
Whole-genome amplification. Wells D, Encyclopaedia of the Human Genome. 2003 doi:
The "vanishing embryo" phenomenon in an oocyte donation programme Rodriguez-Gonzalez M, Serra V, Garcia-Velasco J A, Pellicer A, Remohi J, Hum Reprod. Mar. 2002 doi: 10.1093/humrep/17.3.798
The "vanishing embryo" phenomenon in an oocyte donation programme. Rodriguez-Gonzalez M, Serra V, Garcia-Velasco J A, Pellicer A, Remohi J, Fertil Steril. 2002 doi:
Human endometrial mucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst Meseguer M, Aplin J D, Caballero-Campo P, O'Connor J E, Martin J C, Remohi J, Pellicer A, Simon C, Biol Reprod. Feb. 2001 doi: 10.1095/biolreprod64.2.590
Analysis of SAW properties of epitaxial ZnO films grown on R-Al2O3 substrates. Emanetoglu NW, Patounakis G, Liang S, Gorla CR, Wittstruck R, Lu Y, IEEE Trans Ultrason Ferroelectr Freq Control. 2001 doi:
Future developments in preimplantation genetic diagnosis. Harper J, Wells D, Preimplantation Genetic Diagnosis. 2001 doi:
Two-step metalorganic chemical vapor deposition growth of piezoelectric ZnO thin film on SiO2/Si substrate. Muthukumar S, Emanetoglu NW, Patounakis G, Gorla CR, Liang S, Lu Y, J Vac Sci Technol A. 2001 doi:
Analysis of temperature compensated SAW modes in ZnO/SiO2/Si multilayer structures Emanetoglu NW, Patounakis G, Muthukumar S, Lu Y, 2000 IEEE Ultrasonics Symposium. 2000 doi:
Aryl-alcohol oxidase protein sequence: a comparison with glucose oxidase and other FAD oxidoreductases. Varela E, Martinez AT, Martinez MJ, Biochem Biophys Acta. 2000 doi:
Comparative Genomic Hybridization Reveals Extensive Variation Among Different MCF-7 Cell Stocks. Jones C, Payne J, Wells D, Delhanty JDA, Lakhani SR, Kortenkamp A, Cancer Genet Cytogenet. 2000 doi:
Deletion and duplication of the adenomatous polyposis coli gene resulting from an interchromosomal insertion involving 5 (q22q23.3) in the father. Hastings RJ, Svennevik EC, Setterfield B, Wells D, Delhanty JDA, Mackinnon H, J Med Genet. 2000 doi:
Influence of sequence duration and number of electrical pulses upon rabbit oocyte activation and parthenogenetic in vitro development. Escriba M J, Garcia-Ximenez F, Anim Reprod Sci. 2000 doi:
Southern blot screening for lignin peroxidase and aryl-alcohol oxidase genes in 30 fungal species Varela E, Martinez AT, Martinez MJ, Biotechnology. 2000 doi:
Use of a variable electrical pulsing sequence in rabbit oocyte activation. Escriba M J, Garcia-Ximenez F, Reprod Nutr Dev. 2000 doi:
Detailed chromosomal and molecular genetic analysis of single cells by whole genome amplification and comparative genomic hybridisation. Wells D, Sherlock JK, Handyside AH, Delhanty JDA, Nucleic Acids Res. 1999 doi:
Electroactivation of rabbit oocytes in an hypotonic pulsing medium and parthenogenetic in vitro development without cytochalasin B-diploidizing pretreatment. Escriba M J, Garcia-Ximenez F, Theriogenology. 1999 doi:
Genomic instability in gadd45-deficient mice. Hollander MC, Sheikh MS, Bulavin D, Lundgren K, Zhan Q, Henmueller L, Sheehy R, Molinaro T A, Kim KE , Tolosa E, Ashwell JD, Rosenberg M, S-Fernandez, P Morgan, Nature Genetics. 1999 doi:
Molecular cloning of aryl-alcohol oxidase from the fungus Pleurotus eryngii, an enzyme involved in lignin degradation. Varela E, Martinez AT, Martinez MJ, Biochem J. 1999 doi:
A prospective, randomized trial of nifedipine vs. ritodrine in threatened preterm labor Garcia-Velasco J A, Gonzalez A, Int J Gynaecol Obstet. 1998 doi:
Hysterosalpingo contrast sonography (HyCoSy) for the assessment of tubal patency Soares S R, Soares S R, Cançado ML, Camargos AF, Hum Reprod. 1998 doi:
Midtrimester urine human chorionic gonadotropin b-subunit core fragment levels and the subsequent development of preeclampsia. Bahado-Singh RO, Oz U, Isozaki T, Seli E, Kovanci E, Hsu CD, Cole L, Am J Obstet Gynecol. 1998 doi:
The detection of diminished ovarian reserve in infertile women. Sharara FI, Scott R T, Seifer DB, Am J Obstet Gynecol. 1998 doi:
Ovarian reserve screening. Sharara FI, Scott R T, Inf Reprod Med Clin N Am. 1997 doi:
Differential and tissue-specific regulation of (pro)insulin and insulin-like growth factor-I mRNAs and levels of thyroid hormones in growth-retarded embryos. Serna J, Gonzalez-Guerrero PR, Scanes CG, Prati M, Morreale G, De Pablo F, Growth Regul. 1996 doi:
Tru-Trax in vitro cervical mucus penetration test in predicting fertilization and pregnancy rates in in vitro fertilization. Sharara FI, Illions EH, Coddington CC, Scott R T, Hum Reprod. 1995 doi:
Use of the GnRH-agonist stimulation test in the diagnosis of ovarian remnant syndrome. Scott R T, Beatse SN, Illions EH, Snyder RR, J Reprod Med. 1995 doi:
Tru-trax in vitro cervical mucus penetration testing Sharara FI, Beatse SN, Bailey SA, Neal GK, Coddington CC, Scott R T, Hum Reprod. 1994 doi:
Hemizona assay: Assessment of human spermatozoa dysfunction and its correlation with in vitro fertilization results. Oehninger S, Scott R T, Muasher SJ, Coddington CC, Acosta AA, Hodgen GD, Advances in Assisted Reproductive Technologies. 1990 doi:
Validation of the hemizona assay (HZA) in a monkey model: Influence of oocyte maturational stages. Oehninger SC, Coddington CC, Scott R T, Franken D, Acosta AA, Hodgen GD, Fertil Steril. 1989 doi:

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ESHRE 2020 O-270 A nobel long-range DNA sequencing approach improves the design of new protocols for preimplantation genetic testing of monogenic disease (PGT-M). Leaver M Kubikova N Tao X Jalas C Wells D Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2019 O-74 DOES PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A) HARM EMBRYOS? NO—A MULTI-CENTER, PROSPECTIVE, BLINDED, NON-SELECTION STUDY EVALUATING THE PREDICTIVE VALUE OF AN ANEUPLOID DIAGNOSIS AND IMPACT OF BIOPSY Tiegs AW Tao X Whitehead CR Neal SA Osman EK Kim G Hanson BM Seli E Patounakis G Gutmann J Castlebaum A Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2019 P-166: Impact of embryo replacement position (ERP) on euploid frozen embryo transfer (FET) outcomes Bayram A De Munck N ElKhatib I Arnanz A El Damen A Abdala A Melado L Lawrenz B Fatemi H Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine O-234: Is ICSI ethically supported by evidence as the method of fertilisation in donor oocyte cycles, in the absence of a medical indication? Supramaniam P Granne I Becker C Lim L.M Venkatakrishnan R Mittal M Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2019 NGS of Oocytes from Endometriosis Patients Reveals a Differential Transcriptomic Pattern Ferrero H Corachán A Quiñonero A Carbajo-García C Alamá P Tejera A Taboas E Muñoz E Pellicer A Domínguez F Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology Acute DEHP Exposure in Endometrial Epithelial Cells Does Not Phenocopy the Alterations Described in Endometriosis. Gonzalez-Martin R Quiñonero A Pérez S Salsano S Domínguez F Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology Association of Blood Cadmium and Lead Levels with Reproductive Lifespan Among Postmenopausal Women: NHANES 2005-2014. Gonzalez-Martin R Telez-Plaza M Domínguez F Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology Implications of Telomere Biology in Female Reproductive Aging Using the SAMP8 Mouse Model Sánchez-de-Puerta I González-García M Varela E Mor A Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology Novel Non-Classic Progesterone P4 Receptor PGRMC1 Interactions and Functionality Reveal a Key Role Salsano S Quiñonero A Yañez-Mo Gómez A Pérez S Dominguez F Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2018 Evaluating mitochondrial stress response gene clpp-regulated dna methylome dynamics in female reproductive aging Duan J Jiang Z Seli E Tian X Wang T Zhang M Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology Validation of simultaneous diagnosis of single gene disorder (sgd) and next generation sequencing (ngs) - based comprehensive chromosomal aneuploidy screening (ccs) from a single trophectoderm (te) biopsy Rajchel J Vega C Garnsey HM Scott I Jalas C Tao X Scott RT Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology Ultra-low oxygen (o2) tension after day 3 of in vitro development does not alter blastocyst transcriptome: a comparison of 2% versus 5% o2 tension in extended culture Morin SJ Wang T Tao X Earnhardt M Seli E Scott RT Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology Abc trial: appraisal of body content. Frozen embryo cycles are not impacted by the negative effects of obesity seen in fresh cycles Kim G Morin SJ Patounakis G Juneau C Neal SA Presented at the 65th Annual Meeting of the Society for Reproductive Investigation Evaluation of sperm mitochondrial dna copy number as a predictor of in vitro fertilization/intracytoplasmic sperm injection (ivf/icsi) cycle outcomes in a large infertile population Tiegs W Tao X Landis J Rajchel J Bedard JL Seli E Wells D Fragouli E Scott RT Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
ESHRE 2018 LH gonadoprotection against ovarian damage induced by alkytaing drugs in adult mouse ovaries. Castillo LM Buigues A Pellegrini L Rossi V Klinger F Pellicer A Herraiz S Presented at the 73rd annual meeting of the American Society of Reproductive Medicine Functional genomic meta-analysis identifies similarities between endometrial-related subfertilities Devesa A Sebastian-Leon P Garcia-Garcia F Arnau V Pellicer A Diaz-Gimeno P Presented at the 73rd annual meeting of the American Society of Reproductive Medicine Protein kinase A modulation by nitric oxide during human sperm capacitation Staicu FD Martinez-Soto JC Matas C Presented at the 73rd annual meeting of the American Society of Reproductive Medicine Non-classical progesterone signaling may be sufficient to induce decidualization in Human Endometrial Stromal Cells (ESC) Salsano S Quiñonero A Pérez S González-Ravina C Simón C Dominguez F Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology Retrospective analysis of DuoStim cycles shows similar overall performance and oocyte quality between follicular and luteal phase stimulation Cecchino G Cerrillo M Cruz M Garcia Velasco J Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology FSH exposure between day 8 and day of Hcg administration is an independent predictor of serum progesterone rise Fatemi H Griesinger G Teal V Polyzos N Bosch E Johnson B Dos Santos S Garcia Velasco J Stoop D Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2018 Phytoestrogens (Soy-Derived Metabolites) May Act Like Endometrial Disruptors Altering Decidualization of Human Endometrial Stromal Cells Perez S Salsano S Quiñonero A Dominguez F Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2017 Significance of endometrial lining decrease after progesterone start in synthetic frozen embryo transfer (FET) cycles Colombo S Franasiak JM Kaser DJ Molinaro T Bergh PA Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology

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