Desarrollo tecnológico
La tecnología en reproducción asistida ha evolucionado desde el primer recién nacido tras el primer tratamiento de FIV hace ya casi 3 décadas. Mientras que la endocrinología reproductiva y la infertilidad son campos relativamente nuevos, la tecnología en esta área de la medicina ha evolucionado a un ritmo acelerado y lo ha hecho en todas las fases del proceso. En el aspecto clínico, hemos mejorado los sistemas de monitorización de ciclos de FIV, evaluado los índices de masa corporal de las pacientes y analizado el impacto del microbioma, la dieta de los pacientes y su configuración genética. Dentro de los laboratorios de embriología, hemos observado un avance tecnológico que ha mejorado el cultivo embrionario y ha reducido la discrepancia de datos y ha ayudado a eliminar obstáculos para descubrir nuevas patologías.
El análisis de embriones mediante nuevas técnicas que estudian el ADN, el RNA, las proteínas, así como la epigenética, ha contribuido a lograr un mejor conocimiento sobre los mecanismos biológicos del desarrollo embrionario. Estos descubrimientos han originado multitud de cuestiones que se deben resolver.
Investigadores trabajando en este área
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Públicaciones en este área
- Introduction: IVF's 40th world birthday.
Niederberger C Pellicer A
Fertil Steril. 2018 Jul 1;110(1):4. doi: 10.1016/j.fertnstert.2018.05.017.
- Forty years of IVF.
Niederberger C Pellicer A Cohen J Gardner DK Palermo GD Neill CL Chow S Rosenwaks Z Cobo A Swain JE Schoolcraft WB Frydman Bishop LA Aharon D Gordon C New E Decherney A Tan SL Paulson RJ Goldfarb JM Brännström M Donnez JSilber S Dolmans MM Simpson JL Handyside AH Munné S Eguizabal C Montserrat N Izpisua Belmonte JC Trounson A Simon C Tulandi T Giudice LC Norman RJ Hsueh AJ Sun Y Laufer N Kochman R Eldar-Geva T Lunenfeld B Ezcurra D Hooghe T Fauser BC Tarlatzis B Meldrum D Casper R Fatemi H Devroey P Galliano D
Fertil Steril. 2018 Jul 15;110(2):185-324.e5. doi: 10.1016/j.fertnstert.2018.06.005. Review.
- Ovarian manipulation in ART: going beyond physiological standards to provide best clinical outcomes.
Ortega I García-Velasco JA Pellicer A
J Assist Reprod Genet. 2018 Jul 28. doi: 10.1007/s10815-018-1258-6. [Epub ahead of print] Review.
- Current status and future prospects of noninvasive preimplantation genetic testing for aneuploidy.
Fragouli E Wells D
Fertil Steril. 2018 Aug;110(3):408-409. doi: 10.1016/j.fertnstert.2018.04.021. No abstract available.
- Relevance of assessing the uterine microbiota in infertility.
Moreno I Simon C
Fertil Steril. 2018 Aug;110(3):337-343. doi: 10.1016/j.fertnstert.2018.04.041. Review.
- Clinical reassessment of human embryo ploidy status between cleavage and blastocyst stage by Next Generation Sequencing.
Liñán A Lawrenz B El Khatib I Bayram A Arnanz A Rubio C Chopra R Fatemi H
PLoS One. 2018 Aug 22;13(8):e0201652. doi: 10.1371/journal.pone.0201652. eCollection 2018.
- The pros and cons of preimplantation genetic testing for aneuploidy: clinical and laboratory perspectives.
Rosenwaks Z Handyside AH Fiorentino F Gleicher N Paulson RJ Schattman GL Scott RT Summers MC Treff NR Xu K
Fertil Steril. 2018 Aug;110(3):353-361. doi: 10.1016/j.fertnstert.2018.06.002. No abstract available.
- Let's rescue oocytes: in vitro maturation 2.0 is coming.
Escrich L Pellicer A Meseguer M
Fertil Steril. 2018 Sep;110(4):638-639. doi: 10.1016/j.fertnstert.2018.05.019. No abstract available.
- The role of mitochondrial activity in female fertility and assisted reproductive technologies: overview and current insights.
Cecchino GN Seli E Alves da Motta EL Garcia Velasco J
Reprod Biomed Online. 2018 Mar 8. pii: S1472-6483(18)30095-6. doi: 10.1016/j.rbmo.2018.02.007. [Epub ahead of print] Review.
- Cumulus cell transcriptome profiling is not predictive of live birth after in vitro fertilization: a paired analysis of euploid sibling blastocysts.
Green KA Franasiak JM Werner MD Tao X Landis JN Scott RT Treff NR
Fertil Steril. 2018 Feb 7. pii: S0015-0282(17)32045-9. doi: 10.1016/j.fertnstert.2017.11.002. [Epub ahead of print]
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Presentaciones en esta área
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Costa-Borges N Spath K Nikitos E Ribustello L Miguel-Escalada I Rink K Kostaras K Psathas P Wells D Calderon G Cytoplasm replacement by spindle transfer demonstrates enhanced embryo development without compromising euploidy rates: pre-clinical study with donor oocytes Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ASRM 2018
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Del Gallego R Alegre L Cnaani T Shnizer S Remohí J Meseguer M Clinical validation of a non-invasive embryo selection algorithm combining time-lapse morphokinetics and the oxidative status of spent embryo culture media. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
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Devesa A Sebastian-Leon P Garcia-Garcia F Arnau V Pellicer A Diaz-Gimeno P
Functional genomic meta-analysis identifies similarities between endometrial-related subfertilities
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Elkhatib I Lawrenz B Linan A Arnanz A Bayram A Fatemi H
Comprehensive comparison of Trophectoderm (TE) and Inner cell mass (ICM) by Next Generation Sequencing (NGS)
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Labarta E Herraiz S De Los Santos MJ Marzal A Jose Escribá M Buigues A Pellicer A
Autologous mitochondrial transfer (AugmentSM) as a complementary technique to ICSI to improve oocyte and embryo quality in IVF patients. A Randomized Pilot Study.
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Melado Vilades L Lawrenz B Sibal J Abu E Navarro A Fatemi H
Fully automated assay assessment of intra-and inter-cycle variation for anti-müllerian hormone during the natural cycle
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Azkargorta M Escobes I Lloro I Osinalde N Corral B Exposito A Prieto B Elortza F Matorras R
Differential proteomic analysis of endometrial fluid suggets increased inflammation and extracellular matrix remodeling in non-implantative IVF cycles
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Morin SJ Tiegs A Jalas C Zhan Y Landis J Neal S Franasiak JM Scott RT
Higher resolution aneuploidy screening with targeted NGS may increase the pool of transferrable embryos despite inclusion of segmental and mosaic range diagnostic categories
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Meseguer M Zaninovic N Nogueira F Nogueira O Oliana T Wilkinson L
Using Artificial Intelligence (AI) and Time-Lapse to improve human blastocyst morphology evaluation
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Labarta E Herraiz S De Los Santos MJ Marzal A Jose Escribá M Buigues A Pellicer A
Autologous stem cell ovarian transplant to improve ovarian response and reproductive outcomes in poor responder patients
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Morin SJ Tao X Bedard J Landis J Zhan Y Scott RT Seli E Epigenetic Clock Model of Somatic Aging Accurately Predicts Chronologic Age When Applied to White Blood Cells But Not Cumulus Cells in Reproductive Age Women Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
SRI 2018
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Tao X Zhan Y Scott K Scott RT Seli E
DNA methylation is associated with ploidy status, delayed blastulation, and patient age in human embryos
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
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Tao X Scott RT Seli E Removal of amplicons in targeted NGS CCS: a pathway to discovery of novel embryo viability biomarkers Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2017
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Tao X Zhan Y Scott K Scott RT Seli E
Assessment of DNA methylation in human embryos
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Tao X Zhan Y Scott RT Bedard JL Scott RT Treff N
Tracking implanted embryos using cell-free fetal DNA from maternal circulation at 9 weeks gestation by targeted NGS
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Alegre L Arrones S Shnizer S Tzali C Beltrán D De los Santos MJ Pellicer A Meseguer M Clinical validation of a noninvasive biomarker for embryo selection based on thermochemiluminescence analysis of the embryo spent culture medium Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017
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Alegre L Aparicio-Ruíz B Loewke K Arrones S Albert C Remohí J Meseguer M
Clinical validation of a new automated analysis for embryo selection based on time-lapse technology
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Diaz-Gimeno P Sebastian-Leon P Remohí J Garrido N Pellicer A
New transcriptomic insight improves endometrial Recurrent Implantation Failure (RIF) diagnosis and distinguishes clearly between a displaced and a disrupted Window Of Implantation (WOI)
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Laisk T Suhorutshenko M Kukushkina V Velthut-Meikas A Magi R Peters M Altmäe S Krjut?kov K Martinez-Blanch JF Codoñer FM Vilella F Simon C Salumets A
Novel endometrial receptivity markers detected in largescale RNA-sequencing study combining samples from different populations
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Shah P Banker M Singh S Patel D Kotadawala A
Clinical outcomes using human euploid embryos after quantification of mitochondrial DNA content as a viability predictor tool
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology