Desarrollo tecnológico
La tecnología en reproducción asistida ha evolucionado desde el primer recién nacido tras el primer tratamiento de FIV hace ya casi 3 décadas. Mientras que la endocrinología reproductiva y la infertilidad son campos relativamente nuevos, la tecnología en esta área de la medicina ha evolucionado a un ritmo acelerado y lo ha hecho en todas las fases del proceso. En el aspecto clínico, hemos mejorado los sistemas de monitorización de ciclos de FIV, evaluado los índices de masa corporal de las pacientes y analizado el impacto del microbioma, la dieta de los pacientes y su configuración genética. Dentro de los laboratorios de embriología, hemos observado un avance tecnológico que ha mejorado el cultivo embrionario y ha reducido la discrepancia de datos y ha ayudado a eliminar obstáculos para descubrir nuevas patologías.
El análisis de embriones mediante nuevas técnicas que estudian el ADN, el RNA, las proteínas, así como la epigenética, ha contribuido a lograr un mejor conocimiento sobre los mecanismos biológicos del desarrollo embrionario. Estos descubrimientos han originado multitud de cuestiones que se deben resolver.
Investigadores trabajando en este área
Leer Mas
Públicaciones en este área
- Bioengineering strategies of the uterus towards improving current investigative models and female reproductive health.
Campo H Cervelló I pellicer A
Facts Views Vis Obgyn. 2019 Mar;11(1):87-99.
- Ovarian stimulated cycles reduce protection of follicular fluid against free radicals.
Pérez-Ruiz I Meijide S Ferrando M Larreategui Z Ruiz-Larrea MB Ruiz-Sanz JI
Free Radic Biol Med. 2019 Oct 8;145:330-335. doi: 10.1016/j.freeradbiomed.2019.10.004. [Epub ahead of print]
- Gonadotropin-Releasing Hormone Analogs for Gonadal Protection During Gonadotoxic Chemotherapy: A Systematic Review and Meta-Analysis.
Sofiyeva N Siepmann T Barlinn K Seli E Ata B
Reprod Sci. 1:1933719118799203. 2018.
- Metabolic imaging with the use of fluorescence lifetime imaging microscopy (FLIM) accurately detects mitochondrial dysfunction in mouse oocytes
Sanchez T Wang T Pedro MV Zhang M Esencan E Sakkas D Needleman D Seli E
Fertil Steril, 110(7):1387-1397. 2018.
- Inter-assay variation and reproducibility of progesterone measurements during ovarian stimulation for IVF.
Lawrenz B Sibal J Garrido N Abu E Jean A Melado L Fatemi HM
PLoS One, 13(11):NA-NA, 2018.
- Pores for thought: preimplantation genetic testing using a nanopore-based DNA sequencer.
Fragouli E Wells D
Fertil Steril, 110(5):853-855, 2018.
- Clinical trial registry alone is not adequate: on the perception of possible endpoint switching and P-hacking.
Hill MJ Connell MT Patounakis G
Hum Reprod, 33(2):341-342, 2018.
- Innovations in assisted reproductive technologies: impact on contemporary donor egg practice and future advances
Christianson MS Bellver J
Fertil Steril, 110(6):994-1002, 2018.
- Autologous mitochondrial transfer as a complementary technique to intracytoplasmic sperm injection to improve embryo quality in patients undergoing in vitro fertilization-a randomized pilot study.
Labarta E De Los Santos MJ Herraiz S Escribà MJ Marzal A Buigues A Pellicer A
Fertil Steril, NA:NA -NA, 2018.
- Anti-müllerian Hormone During Natural Cycle Presents Significant Intra and Intercycle Variations When Measured With Fully Automated Assay.
Melado L Lawrenz B Sibal J Abu E Coughlan C Navarro AT Fatemi HM
Front Endocrinol (Lausanne), 9:686-692, 2018.
Leer Mas
Presentaciones en esta área
-
Santa-Cruz Caparros-Gonzalez García Velasco JA O-156 HAIR CORTISOL AS A NEW BIOMARKER OF UNDERLYING CHRONIC STRESS, ANXIETY AND DEPRESSION IN INFERTILITY: A PILOT STUDY Presented at 75th American Society of Reproductive Medicine Scientific Congress
ASRM 2019
-
Osman EK Wang T Yang M Zhan Y Juneau C Morin SJ Seli E Scott RT Franasiak JM
O-247 VARYING LEVELS OF SERUM ESTRADIOL DO NOT ALTER THE TIMING OF THE EARLY ENDOMETRIAL SECRETORY TRANSFORMATION
Presented at 75th American Society of Reproductive Medicine Scientific Congress
-
Marugappan G Kim G Kort JD Hanson BM Neal SA Tiegs AW Osman EK Scott RT Lathi RB
P-110 Blastocyst grade predicts outcome after frozen euploid transfer in patients with recurrent pregnancy loss
Presented at 75th American Society of Reproductive Medicine Scientific Congress
-
Campo H García-Domínguez X López-Martínez S Antón J Marco-jiménez F Cervelló I Biomimetic Coatings from Decellularized Rabbit Endometrium Inuence the In Vitro In Vitro Development of PreImplantation Embryos. Presented at the 66th Annual Meeting of the Society for Reproductive Investigation
SRI 2019
-
Costa-Borges N Spath K Nikitos E Ribustello L Miguel-Escalada I Rink K Kostaras K Psathas P Wells D Calderon G Cytoplasm replacement by spindle transfer demonstrates enhanced embryo development without compromising euploidy rates: pre-clinical study with donor oocytes Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ASRM 2018
-
Del Gallego R Alegre L Cnaani T Shnizer S Remohí J Meseguer M Clinical validation of a non-invasive embryo selection algorithm combining time-lapse morphokinetics and the oxidative status of spent embryo culture media. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
-
Devesa A Sebastian-Leon P Garcia-Garcia F Arnau V Pellicer A Diaz-Gimeno P
Functional genomic meta-analysis identifies similarities between endometrial-related subfertilities
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
-
Elkhatib I Lawrenz B Linan A Arnanz A Bayram A Fatemi H
Comprehensive comparison of Trophectoderm (TE) and Inner cell mass (ICM) by Next Generation Sequencing (NGS)
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
-
Labarta E Herraiz S De Los Santos MJ Marzal A Jose Escribá M Buigues A Pellicer A
Autologous mitochondrial transfer (AugmentSM) as a complementary technique to ICSI to improve oocyte and embryo quality in IVF patients. A Randomized Pilot Study.
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
-
Melado Vilades L Lawrenz B Sibal J Abu E Navarro A Fatemi H
Fully automated assay assessment of intra-and inter-cycle variation for anti-müllerian hormone during the natural cycle
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
-
Azkargorta M Escobes I Lloro I Osinalde N Corral B Exposito A Prieto B Elortza F Matorras R
Differential proteomic analysis of endometrial fluid suggets increased inflammation and extracellular matrix remodeling in non-implantative IVF cycles
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
-
Morin SJ Tiegs A Jalas C Zhan Y Landis J Neal S Franasiak JM Scott RT
Higher resolution aneuploidy screening with targeted NGS may increase the pool of transferrable embryos despite inclusion of segmental and mosaic range diagnostic categories
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
-
Meseguer M Zaninovic N Nogueira F Nogueira O Oliana T Wilkinson L
Using Artificial Intelligence (AI) and Time-Lapse to improve human blastocyst morphology evaluation
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
-
Labarta E Herraiz S De Los Santos MJ Marzal A Jose Escribá M Buigues A Pellicer A
Autologous stem cell ovarian transplant to improve ovarian response and reproductive outcomes in poor responder patients
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
-
Morin SJ Tao X Bedard J Landis J Zhan Y Scott RT Seli E Epigenetic Clock Model of Somatic Aging Accurately Predicts Chronologic Age When Applied to White Blood Cells But Not Cumulus Cells in Reproductive Age Women Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
SRI 2018
-
Tao X Zhan Y Scott K Scott RT Seli E
DNA methylation is associated with ploidy status, delayed blastulation, and patient age in human embryos
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
-
Tao X Scott RT Seli E Removal of amplicons in targeted NGS CCS: a pathway to discovery of novel embryo viability biomarkers Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2017
-
Tao X Zhan Y Scott K Scott RT Seli E
Assessment of DNA methylation in human embryos
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
-
Tao X Zhan Y Scott RT Bedard JL Scott RT Treff N
Tracking implanted embryos using cell-free fetal DNA from maternal circulation at 9 weeks gestation by targeted NGS
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
-
Alegre L Arrones S Shnizer S Tzali C Beltrán D De los Santos MJ Pellicer A Meseguer M Clinical validation of a noninvasive biomarker for embryo selection based on thermochemiluminescence analysis of the embryo spent culture medium Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017
-
Alegre L Aparicio-Ruíz B Loewke K Arrones S Albert C Remohí J Meseguer M
Clinical validation of a new automated analysis for embryo selection based on time-lapse technology
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
-
Diaz-Gimeno P Sebastian-Leon P Remohí J Garrido N Pellicer A
New transcriptomic insight improves endometrial Recurrent Implantation Failure (RIF) diagnosis and distinguishes clearly between a displaced and a disrupted Window Of Implantation (WOI)
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
-
Laisk T Suhorutshenko M Kukushkina V Velthut-Meikas A Magi R Peters M Altmäe S Krjut?kov K Martinez-Blanch JF Codoñer FM Vilella F Simon C Salumets A
Novel endometrial receptivity markers detected in largescale RNA-sequencing study combining samples from different populations
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
-
Shah P Banker M Singh S Patel D Kotadawala A
Clinical outcomes using human euploid embryos after quantification of mitochondrial DNA content as a viability predictor tool
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology