Desarrollo tecnológico
La tecnología en reproducción asistida ha evolucionado desde el primer recién nacido tras el primer tratamiento de FIV hace ya casi 3 décadas. Mientras que la endocrinología reproductiva y la infertilidad son campos relativamente nuevos, la tecnología en esta área de la medicina ha evolucionado a un ritmo acelerado y lo ha hecho en todas las fases del proceso. En el aspecto clínico, hemos mejorado los sistemas de monitorización de ciclos de FIV, evaluado los índices de masa corporal de las pacientes y analizado el impacto del microbioma, la dieta de los pacientes y su configuración genética. Dentro de los laboratorios de embriología, hemos observado un avance tecnológico que ha mejorado el cultivo embrionario y ha reducido la discrepancia de datos y ha ayudado a eliminar obstáculos para descubrir nuevas patologías.
El análisis de embriones mediante nuevas técnicas que estudian el ADN, el RNA, las proteínas, así como la epigenética, ha contribuido a lograr un mejor conocimiento sobre los mecanismos biológicos del desarrollo embrionario. Estos descubrimientos han originado multitud de cuestiones que se deben resolver.
Investigadores trabajando en este área
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Públicaciones en este área
- Gonadotropin-Releasing Hormone Analogs for Gonadal Protection During Gonadotoxic Chemotherapy: A Systematic Review and Meta-Analysis.
Sofiyeva N Siepmann T Barlinn K Seli E Ata B
Reprod Sci. 1:1933719118799203. 2018.
- Metabolic imaging with the use of fluorescence lifetime imaging microscopy (FLIM) accurately detects mitochondrial dysfunction in mouse oocytes
Sanchez T Wang T Pedro MV Zhang M Esencan E Sakkas D Needleman D Seli E
Fertil Steril, 110(7):1387-1397. 2018.
- Inter-assay variation and reproducibility of progesterone measurements during ovarian stimulation for IVF.
Lawrenz B Sibal J Garrido N Abu E Jean A Melado L Fatemi HM
PLoS One, 13(11):NA-NA, 2018.
- Pores for thought: preimplantation genetic testing using a nanopore-based DNA sequencer.
Fragouli E Wells D
Fertil Steril, 110(5):853-855, 2018.
- Clinical trial registry alone is not adequate: on the perception of possible endpoint switching and P-hacking.
Hill MJ Connell MT Patounakis G
Hum Reprod, 33(2):341-342, 2018.
- Innovations in assisted reproductive technologies: impact on contemporary donor egg practice and future advances
Christianson MS Bellver J
Fertil Steril, 110(6):994-1002, 2018.
- Autologous mitochondrial transfer as a complementary technique to intracytoplasmic sperm injection to improve embryo quality in patients undergoing in vitro fertilization-a randomized pilot study.
Labarta E De Los Santos MJ Herraiz S Escribà MJ Marzal A Buigues A Pellicer A
Fertil Steril, NA:NA -NA, 2018.
- Anti-müllerian Hormone During Natural Cycle Presents Significant Intra and Intercycle Variations When Measured With Fully Automated Assay.
Melado L Lawrenz B Sibal J Abu E Coughlan C Navarro AT Fatemi HM
Front Endocrinol (Lausanne), 9:686-692, 2018.
- Data sharing requirements: perspectives from three authors.
Barnhart KT Legro RS Scott RT
Fertil Steril, 109 (1):44-47, 2018.
- Cumulus cell transcriptome profiling is not predictive of live birth after in vitro fertilization: a paired analysis of euploid sibling blastocysts.
Green KA Franasiak JM Werner MD Tao X Landis JN Scott RT Treff NR
Fertil Steril, 109(3):460-466, 2018.
- Search for new molecular biomarkers to diagnose endometriosis continues.
Domínguez F
Fertil Steril, 109(4):615-616, 2018.
- Preclinical Validation of a Targeted Next Generation Sequencing-based Comprehensive Chromosome Screening Methodology in Human Blastocysts.
Zimmerman RS Tao X Marin D Werner MD Hong K Lonczak A Landis J Taylor D Zhan Y Scott RT Treff NR
Mol Hum Reprod, 24:37-45, 2018
- Reduction in oxygen tension to 2% in extended culture: a more physiologic system may mean more blastocysts available for transfer.
Morin SJ
Fertil Steril, 109(6):1002-1003, 2018.
- Should we consider telomere length and telomerase activity in male factor infertility?
Balmori C Varela E
Curr Opin Obstet Gynecol, 30(3):197-202, 2018.
- Extracellular vesicles: a promising tool for assessment of embryonic competence.
Marin D Scott RT
Curr Opin Obstet Gynecol, 30(3):171-178, 2018.
- Fetal sex determination in twin pregnancies using cell free fetal DNA analysis.
Milan M Mateu E Blesa D Clemente-Ciscar M Simón C
Prenat Diagn, 38(8):578-584, 2018.
- The role of mitochondrial activity in Female fertility and assisted reproductive technologies: overview and current insights.
Cecchino GN Seli E Alves da Motta EL García-Velasco JA
Reprod Biomed Online, 36(6):686-697, 2018.
- Cumulus cell transcriptome profiling is not predictive of live birth after in vitro fertilization: a paired analysis of euploid sibling blastocysts.
Green KA Franasiak JM Werner MD Tao X Landis JN Scott RT Treff NR
Fertil Steril, 109(3):460-466, 2018.
- Human Endometrial Reconstitution From Somatic Stem Cells: The Importance of Niche-Like Cells.
Lopez-Perez N Gil-Sanchis C Ferrero H Faus A Diaz A Pellicer A Cervelló I Simón C
Reprod Sci, NA:NA-NA, 2018.
- Validation of a targeted next generation sequencing-based comprehensive chromosomescreening platform for detection of triploidy in human blastocysts.
Marin D Zimmerman R Tao X Zhan Y Scott RT Treff NR
Reprod Biomed Online, 36(4):388-395, 2018.
- Proteomic pattern of implantative human endometrial fluid in in vitro fertilization cycles.
Matorras R Quevedo S Corral B Prieto B Exposito A Mendoza R Rabanal A Diaz-Nuñez M Ferrando M Elortza F Ametzazurra A Nagore D
Arch Gynecol Obstet, 297(6):1577-1586, 2018.
- NGS Analysis of Human Embryo Culture Media Reveals miRNAs of Extra Embryonic Origin.
Sanchez-Ribas I Díaz-Gimeno P Quiñonero A Ojeda M Larreategui Z Ballesteros A Domínguez F
Reprod Sci, NA:NA-NA, 2018.
- Origin and composition of cell-free DNA in spent medium from human embryo culture during preimplantation development.
Vera-Rodriguez M Diez-Juan A Jimenez-Almazan J Martínez S Navarro R Peinado V Mercader A Meseguer M Blesa D Moreno I Valbuena D Rubio C Simón C
Hum Reprod, 33(4):745-756, 2018.
- 3D NIR-II Molecular Imaging Distinguishes Targeted Organs with High-Performance NIR-II Bioconjugates.
Zhu S Herraiz S Yue J Zhang M Wan H Yang Q Ma Z Wang Y He J Antaris AL Zhong Y Diao S Feng Y Zhou Y Yu K Hong G Liang Y Hsueh AJ Dai H
Adv Mater, 30(13):NA-NA, 2018.
- Validation of a targeted next generation sequencing-based comprehensive chromosomescreening platform for detection of triploidy in human blastocysts.
Marin D Zimmerman R Tao X Zhan Y Scott RT Treff NR
Reprod Biomed Online, pii: S1472-6483(17)30710-1. doi: 10.1016/j.rbmo.2017.12.015, 2018.
- Detection of mosaicism at blastocyst stage with the use of high-resolution next-generation sequencing.
Munné S Wells D
Fertil Steril, 107:1085–1091, 2017.
- Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.
Zhang J Liu H Luo S Lu Z Chávez-Badiola A Liu Z Yang M Merhi Z Silber SJ Munné S Konstandinidis M Wells D Huang T
Reprod Biomed Online, 34:361-368, 2017.
- Detailed investigation into the cytogenetic constitution and pregnancy outcome of replacing mosaic blastocysts detected with the use of high-resolution next-generation sequencing.
Munné S Blazek J Large M Martinez-Ortiz PA Nisson H Liu E Tarozzi N Borini A Becker A Zhang J Maxwell S Grifo J Babariya D Wells D Fragouli E
Fertil Steril, 108:62-71, 2017.
- Karyomapping: a single centre experience from application of methodology to ongoing pregnancy and live-birth rates.
Ben-Nagi J Wells D Doye K Exeter H Drew E Alfarawati S Naja R Serhal P Loutradi K
Reprod Biomed Online, 35:264–271, 2017.
- Mitochondrial DNA Quantification- the devil in the detail
Wells D Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munné S Fragouli E
Hum Reprod, 32:2150–2151, 2017.
- Mitochondrial DNA quantity as a biomarker for blastocyst implantation potential.
Wells D
Fertil Steril, 108:742–747, 2017.
- Genome editing reveals a role for OCT4 in human embryogenesis.
Fogarty N McCarthy A Snijders KE Powell BE Kubikova N Blakeley P Lea R Elder K Wamaitha S Daesik K Maciulyte V Kleinjung J Kim J Wells D Vallier L Bertero A Turner J Niakan K
Nature, 550:67-73, 2017.
- Mitochondrial dysfunction and ovarian senescence
Wang T Zhang M Jiang Z Seli E
Am J Reprod Immunol, 77(5), 2017
- Levels of trophectoderm mitochondrial DNA do not predict the reproductive potential of sibling embryos.
Treff NR Zhan Y Tao X Olcha M Han M Rajchel J Morrison L Morin SJ Scott RT
Hum Reprod. 2017 Apr 1;32(4):954-962. doi: 10.1093/humrep/dex034.
- Sperm DNA damage output parameters measured by the alkaline Comet assay and their importance
Simon L Aston KI Emery BR Hotaling J Carrell DT
LID - 10.1111/and.12608 [doi]. Andrologia, 49(2), 2017.
- Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development.
Guo J Grow EJ Yi C Mlcochova H Maher GJ Lindskog C Murphy PJ Wike CL Carrell DT Goriely A Hotaling J Cairns BR
Cell Stem Cell, 21(4), 533-546.e6, 2017.
- Mitochondrial DNA quantification as a tool for embryo viability assessment: retrospective analysis of data from single euploid blastocyst transfers.
Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Wells D Fragouli E
Hum Reprod, 32: 1282-1292, 2017
- Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts.
Fragouli E Alfarawati S Spath K Babariya D Tarozzi N Borini A Wells D
Hum Genet, 136: 805-819, 2017
- A novel homologous model for noninvasive monitoring of endometriosis progression†.
Ferrero H Buigues A Martinez J Simón C Pellicer A Gomez R
Biol Reprod. 2017 Feb 1;96(2):302-312. doi: 10.1095/biolreprod.116.140756.
- Translocations, Inversions and Other Chromosome Rearrangements.
Morin SJ Eccles J Iturriaga A Zimmerman R
Fertil Steril 2017;107(1):19-26
- Clinical implications of mitochondrial DNA quantification on pregnancy outcomes: a blinded prospective non-selection study
Fragouli E McCaffrey C Ravichandran K Spath K Grifo JA Munné S Wells D
Hum Reprod, 32: 2340-2347, 2017.
- The incidence and origin of segmental aneuploidy in human oocytes and preimplantation embryos.
Babariya D Fragouli E Alfarawati S Spath K Wells D
Hum Reprod, Epub, Nov 8, 2017.
- Mitochondrial DNA Quantification-the devil in the detail.
Wells D Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Fragouli E Borini A Becker A Zhang J Maxwell S Grifo J Babariya D Wells D Fragouli E
Hum Reprod, 32: 2150-2151, 2017.
- Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts.
Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Wells D Fragouli E
Hum Genet, 136: 805-819, 2017.
- Crossing the germline: CRISPR-Cas9 and our responsibility as reproductive endocrinology and infertility physicians.
Kaser DJ Franasiak JM
J Assist Reprod Genet. 2018 Mar;35(3):399-402. doi: 10.1007/s10815-017-1075-3. Epub 2017 Oct 30.
- Type of gonadotropin used during controlled ovarian stimulation induces differential gene expression in human cumulus cells: A randomized study.
Cruz M Requena A Agudo Garcillán D García-Velasco JA
Eur J Obstet Gynecol Reprod Biol. 2017 Jun 8;215:124-133. doi: 10.1016/j.ejogrb.2017.06.014. [Epub ahead of print]
- Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers.
Altmae S Koel M Võsa U Adler P Suhorut?enko M Laisk-Podar T Kukushkina V Saare M Velthut-Meikas A Krjut?kov K Aghajanova L Lalitkumar PG Gemzell-Danielsson K Giudice L Simón C Salumets A
Sci Rep. 2017 Aug 30;7(1):10077. doi: 10.1038/s41598-017-10098-3.
- What Drives Embryo Development? Chromosomal Normality or Mitochondria?
Bayram A Elkhatib I Arnanz A Linan A Ruiz F Lawrenz B Fatemi HM
Case Rep Genet. 2017;2017:4397434. doi: 10.1155/2017/4397434. Epub 2017 Aug 8.
- De- and recellularization of the pig uterus: a bioengineering pilot study.
Campo H Baptista PM Lopez-Perez N Faus A Cervelló I Simón C
Biol Reprod. 2017 Jan 1;96(1):34-45. doi: 10.1095/biolreprod.116.143396.
- Endometrial microbiota-new player in town.
Moreno I Franasiak JM
Fertil Steril. 2017 Jun 8. pii: S0015-0282(17)30417-X. doi: 10.1016/j.fertnstert.2017.05.034. [Epub ahead of print]
- Enhanced techniques to "power" embryonic mitochondria research.
Scott RT
Fertil Steril. 2017 Jan;107(1):59-60. doi: 10.1016/j.fertnstert.2016.11.024. No abstract available
- Levels of trophectoderm mitochondrial DNA do not predict the reproductive potential of sibling embryos.
Treff NR Zhan Y Tao X Olcha M Han M Rajchel J Morrison L Morin SJ Scott RT
Hum Reprod. 2017 Apr 1;32(4):954-962. doi: 10.1093/humrep/dex034.
- Detection of segmental aneuploidy and mosaicism in the human preimplantation embryo: technical considerations and limitations.
Treff N Franasiak JM
Fertil Steril, 107:27-31
- Endometrial microbiota - new player in town.
Moreno I Franasiak JM
Fertil Steril, Epub June 8, 2017.
- Characterizing the endometrial microbiome: next generation sequencing of the 16s ribosomal gene.
Tao X Franasiak JM Zhan Y Rajchel J Bedard J Scott RT Treff N Chu T
Hum Microbiome J, 3:15-21, 2017
- Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children
Diot A Dombi E Lodge T Liao C Morten K Carver J Wells D Child T Johnston I Williams S Poulton J
Biochem Soc Trans, 44:1091–1100, 2016.
- Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy.
Ravichandran K Guzman L Escudero T Zheng X Colls P Jordan A Cohen J Wells D Munné S
Reprod Biomed Online, 33:550–559, 2016.
- The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.
Sermon K Capalbo A Cohen J Coonen E De Rycke M De Vos A Delhanty J Fiorentino F Gleicher N Griesinger G Grifo J Handyside A Harper J Kokkali G Mastenbroek S Meldrum D Meseguer M Montag M Munné S Rienzi L Rubio C Scott KScott RT Simón C Swain J Treff N Ubaldi F Vassena R Vermeesch J Verpoest W Wells D Geraedts J
Mol Hum Reprod, 22:845–857, 2016.
- Why do euploid embryos miscarry? A case-control study comparing the rate of aneuploidy within presumed euploid embryos that resulted in miscarriage or live birth using next-generation sequencing.
Maxwell SM Colls P Hodes-Wertz B McCulloh DH McCaffrey C Wells D Munné S Grifo J
Fertil Steril, 106:1414-1419, 2016.
- Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality.
Cariati F Jaroudi S Alfarawati S Raberi A Alviggi C Pivonello R Wells D
Reprod Biomed Online, 33:404–411, 2016.
- Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.
Hyslop LA Blakeley P Craven L Richardson J Fogarty NM Fragouli E Lamb M Wamaitha SE Prathalingam N Zhang Q O'Keefe H Takeda Y Arizzi L Alfarawati S Tuppen HA Irving L Kalleas D Choudhary M Wells D Murdoch AP Turnbull DM Niakan KKHerbert M
Nature, 534:383–386, 2016.
- Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.
Enciso M Sarasa J Xanthopoulou L Bristow S Bowles M Fragouli E Delhanty J Wells D
Hum Genet, 135:555–568, 2016.
- Preimplantation genetic diagnosis: an overview and recent advances.
Ben-Nagi J Serhal P SenGupta S Doye K Wells D
Obstet Gynaecol, 18:99–106, 2016.
- Current controversies in prenatal diagnosis 4: preimplantation genetic screening should be routinely offered to all preimplantation genetic diagnosis cases.
Harper J Wells D Simpson JL
Prenat Diagn, 36:25–28, 2016.
- Mosaicism: “survival of the fittest” versus “no embryo left behind”.
Munné S Grifo J Wells D
Fertil Steril, 105:1146–1149, 2016.
- Preimplantation genetic diagnosis for infertility.
Wells D Lewin J
In Textbook of Assisted Reproductive technologies, 5th Edition (Informa Healthcare, UK), p346-353. Edited by Gardner D, Weissman A, Howles C, Shoham Z. 2016.
- Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations
Varela E Muñoz M Tejera M Ortega I Blasco M
Nature Communications, 7: 11739-11755.2016.
- Mitochondrial DNA as a biomarker for in vitro fertilization (IVF) outcome
Seli E
Curr Opin Obstet Gynecol, 28:158-63, 2016.
- CYP1A1 3801T>C polymorphism implicated in altered xenobiotic metabolism is not associated with variations in sperm production and function as measured by total motile sperm and fertilization rates wit
Franasiak JM Barnett R Molinaro T Gabriele D Gartmond TD Treff NR Scott RT
Fertil Steril. 106(2):481-6, 2016.
- Genotypically determined ancestry across an infertile population: ovarian reserve and response parameters are not influenced by continental origin.
Olcha M Franasiak JM Shastri S Molinaro T Congdon H Treff NR Scott RT
Fertil Steril, 106(2):475-80. 2016.
- First validated clinical test selects best embryos for IVF and viable pregnancies.
Fragouli E
MLO Med Lab Obs, 48: 38, 2016
- Evaluation of the antiproliferative, proapoptotic, and antiangiogenic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of leiomyoma.
García-Pascual CM Ferrero H Juarez I Martínez J Villanueva A Pozuelo-Rubio M Soengas M Tormo D Simón C Gómez R Pellicer A
Fertil Steril. 2016:105(2):529-38
- Técnicas invasivas y no invasivas en el diagnóstico de embriones humanos.
Calomarde C Carmona L Guerra I Gutiérrez D Santana A Domingo J
Rev Iberoam Fert Rep Hum, 33: 67-72, 2016.
- Optimizing the culture environment and embryo manipulation to help maintain embryo developmental potential
Swain JE Carrell D Cobo A Meseguer M Rubio C Smith GD
Fertil Steril, 105:571-87, 2016.
- Automatic time-lapse instrument is superior to single-point morphology observation for selecting viable embryos: retrospective study in oocyte donation.
Aparicio-Ruiz B Basile N Basile N Pérez Albalá S Bronet F Remohí J Meseguer M
Fertil Steril, 106:1379-85, 2016.
- How much have we learned from time-lapse in clinical IVF?
Castelló D Motato Y Basile N Remohí J Espejo-Catena M Meseguer M
Mol Hum Reprod, 22(10):719-727, 2016
- Embryonic aneuploidy does not differ amongst major ethnicities as determined by genotyping.
Franasiak JM Olcha M Treff N Scott RT
Hum Reprod 31:2391-5, 2016.
- Challenges facing contemporary preimplantation genetic screening.
Juneau C Franasiak JM Treff N
Curr Opin Obstet Gynecol 28:151-7, 2016.
- Preimplantation genetic screening - what a wonderful world it would be!
García-Velasco JA Fauser BC
Reprod Biomed Online. 32:337-8. 2016.
- Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios.
Agarwal A Majzoub A Esteves SC Ko E Ramasamy R Zini A
Transl Androl Urol, 5:935-950, 2016.
- Spermatozoa from infertile patients exhibit differences of DNA methylation associated with spermatogenesis-related processes: an array-based analysis.
Camprubí C Salas-Huetos A Aiese-Cigliano R Godo A Pons M-C Castellano G Grossmann M Sanseverino W Martin-Subero JI Garrido N Blanco J
Reprod Biomed Online, 33:709-719, 2016.
- Detection of Missing Proteins Using the PRIDE Database as a Source of Mass Spectrometry Evidence.
Garin-Muga A Odriozola L Martínez-Val A del Toro N Martínez R Molina M Cantero L Rivera R Garrido N Domínguez F Sanchez del Pino MM Vizcaíno JA Corrales FJ Segura V
J Proteome Res, 15:4101-4115, 2016.
- Decreased fecundity and sperm DNA methylation patterns.
Jenkins TG Aston KI Meyer TD Hotaling J Shamsi MB Johnstone EB Cox KJ Stanford JB Porucznik CA Carrell DT
Fertil Steril, 105(1), 51-7.e1-3, 2016.
- Optimization of microelectrophoresis to select highly negatively charged sperm.
Simon L Murphy K Aston KI Emery BR Hotaling J Carrell DT
J Assist Reprod Genet, 33(6), 679-88, 2016.
- Microfluidics: The future of microdissection TESE?
Samuel R Badamjav O Murphy KE Patel DP Son J Gale BK Carrell DT Hotaling J
Syst Biol Reprod Med, 62(3), 161-70, 2016.
- Teratozoospermia and asthenozoospermia are associated with specific epigenetic signatures.
Jenkins TG Aston KI Hotaling J Shamsi MB Simon L Carrell DT
Andrology, 4(5), 843-9, 2016.
- Predictors of sperm recovery after cryopreservation in testicular cancer.
Hotaling J Patel DP Vendryes C Lopushnyan NA Presson AP Zhang C Muller CH Walsh TJ
Asian J Androl, 18(1), 35-8, 2016.
- Hormone-Based Treatments in Subfertile Males. [Review].
Patel DP Chandrapal JC Hotaling J
Curr Urol Rep, 17(8), 56, 2016.
- Pathophysiologic processes have an impact ot the plasma metabolomics signature of endometriosis patients.
Vicente-Muñoz S Morcillo I Puchades-Carrasco L Payá V Pellicer A Pineda-Lucena A
Fertil Steril, 106 (7): 1733-1741. E1, 2016.
- Human spermatogonial stem cells display limited proliferation in vitro under mouse spermatogonial stem cell culture conditions.
Medrano JV Rombaut C Simón C Pellicer A Goossens E
Fertil Steril, 106 (6): 1539-1549.e8, 2016.
- A randomized and blinded comparison of qpcr and NGS based detection of aneuploidy in a cell line mixture model of blastocyst biopsy mosaicism.
Goodrich D Tao X Bohrer C Lonczak A Xing T Zimmerman R Zhan Y Scott RT Treff NR
Human Reprod, 30(2);276-83, 2015.
- SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts.
Treff NR Thompson K Rafizadeh M Chow M Morrison L Tao X Garnsey H Reda CV Metzgar TL Neal S Jalas C Scott RT Forman E
J Assist Reprod Genet, 33:1115-9, 2016.
- CYP1A1 3801T>C Polymorphism is not Associated with Variations in Total Motile Sperm or Fertilization Rates with ICSI.
Franasiak JM Barnett R Treff N Scott RT
Fertil Steril, 106:481-6, 2016.
- Next Generation Sequencing Based Comprehensive Chromosome Screening in Mouse Polar Bodies, Oocytes, and Embryos.
Treff NR Krisher R Tao X Garnsey H Bohrer C Silva E Landis J Taylor D Scott RT Woodruff TK Duncan FE
Biol Reprod, 94:76, 2016.
- Multiple thrombophilic single nucleotide polymorphisms lack a significant effect on outcomes in fresh IVF cycles: an analysis of 1717 patients.
Patounakis G Bergh E Forman E Tao X Lonczak A Franasiak JM Treff N Scott RT
J Assist Reprod Genet, 33:67-73, 2016.
- Development and validation of concurrent preimplantation genetic diagnosis for single gene disorders and comprehensive chromosomal aneuploidy screening without whole-genome amplification.
Zimmerman RS Jalas C Tao X Fedick AM Kim J Pepe RJ Northrop LE Scott RT Treff NR
Fertil Steril, 105:286-94, 2016.
- Drug gastrointestinal absorption in rat: Strain and gender differences.
Oltra D Mangas-Sanjuan V González-Álvarez I Colon-Useche S González-Álvarez M Bermejo M
Eur J Pharm Sci. 2015 Oct 12;78:198-203. doi: 10.1016/j.ejps.2015.07.021. Epub 2015 Jul 28.
- Variability of permeability estimation from different protocols of subculture and transport experiments in cell monolayers.
Oltra D Mangas-Sanjuan V Centelles-Sangüesa A Gonzalez-Garcia I Sanchez-Castaño G Gonzalez-Alvarez M Casabo VG Merino V Gonzalez-Alvarez I Bermejo M
J Pharmacol Toxicol Methods. 2015 Jan-Feb;71: 21-32. doi: 10.1016/j.vascn.2014.11.004. Epub 2014 Nov 26.
- 24-chromosome PCR for aneuploidy screening.
Werner MD Scott RT
Curr Opin Obstet Gynecol. 2015.
- Karyomapping allows preimplantation genetic diagnosis of a de-novo deletion undetectable using conventional PGD technology.
Giménez C Sarasa J Arjona C Vilamajó E Martínez-Pasarell O Wheeler K Valls G Garcia-Guixé E Wells D
Reprod Biomed Online, 31:770–775, 2015.
- Validation of next-generation sequencing for comprehensive chromosome screening of embryos.
Kung A Munné S Bankowski B Coates A Wells D
Reprod Biomed Online, 31:760–769, 2015.
- Routine use of next-generation sequencing for preimplantation genetic diagnosis of blastomeres obtained from embryos on day 3 in fresh in~vitro fertilization cycles.
?ukaszuk K Pukszta S Wells D Cybulska C Liss J P?óciennik ? Kuczy?ski W Zabielska J
Fertil Steril, 103:1031–1036, 2015.
- Morphokinetics as a predictor of self-correction to diploidy in tripronucleated intracytoplasmic sperm injection-derived human embryos.
Grau N Escrich L Galiana Y Meseguer M García-Herrero S Remohí J Escribà MJ
Fertil Steril, 104(3):728-35, 2015
- Introducing Larger Equipment: A Novel Method in Laparoscopic Surgery with Smaller Port Sites.
Kim S Goodman L Goldberg J
J Minim Invasive Gynecol. 2015 Nov-Dec;22(6S):S136
- The use of morphokinetics as a predictor of implantation: a multicentric study to define and validate an algorithm for embryo selection.
Basile N Vime P Florensa M Aparicio-Ruiz B García-Velasco JA Remohí J Meseguer M
Hum Reprod, 30(2):276-83, 2015.
- Time-Lapse in the IVL lab: how should we assess potential benefit
Basile N Barrière P Meseguer M Fréour T
Hum Reprod, 30(5):1276, 2015
- What does morphokinetics add to embryo selection and in-vitro fertilization?
Basile N Caiazzo M Meseguer M
Curr Opin Obstet Gynecol, 27(3):193-200, 2015.
- Micro-electrophoresis: a noninvasive method of sperm selection based on membrane charge.
Simon L Murphy K Aston K Emery B Hotaling J Carrell D
Fertil Steril, 103(2), 361-6.e3, 2015.
- Targeted Germline Modifications in Rats Using CRISPR/Cas9 and Spermatogonial Stem Cells.
Chapman K Medrano G Jaichander P Chaudhary Waits A Nobrega M Hotaling J Ober C Hamra F
Cell Rep, 10(11), 1828-35, 2015.
- Robotic single-site myomectomy: a step-by-step tutorial.
Gargiulo A Lewis E Kaser DJ Srouji SS
Fertil Steril, 104(5):e13. 2015.
- Techniques for enclosed morcellation in gynecologic surgery.
Srouji S Kaser DJ Gargiulo AR
Fertil Steril103:e34. 2015.
- What does morphokinetics add to embryo selection and in-vitro fertilization outcomes?
Basile N Caiazzo M Meseguer M
Curr Opin Obstet Gynecol, 27:193-200, 2015.
- New strategy for diagnosing embryo implantation potential by combining proteomics and time-lapse technologies.
Domínguez F Meseguer M Aparicio-Ruiz B Piqueras P Quiñonero A Simón C
Fertil Steril, 104:908-914, 2015.
- La tecnología del Time-lapse y su aplicación en las clínicas de reproducción asistida.
Meseguer M Motato M
ASEBIR, 20: 47-52, 2015
- The use of morphokinetics as a predictor of ?implantation: a multicentric study to define and validate an algorithm for embryo selection.
Basile N Vime P Florensa M Aparicio Ruiz B García-Velasco JA Remohí J Meseguer M
Human Reprod, 30(2);276-83, 2015.
- Analysis of embryo morphokinetics, multinucleation and cleavage anomalies using continuous time-lapse monitoring in blastocyst transfer cycles.
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Reprod Biol Endocrinol. 2014 Jun 20;12(1):54.
- Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform.
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Fertil Steril, 102:1385–1392, 2014.
- Genome-wide karyomapping accurately identifies the inheritance of single-gene defects in human preimplantation embryos in vitro.
Natesan SA Bladon AJ Coskun S Qubbaj W Prates R Munné S Coonen E Dreesen JC Stevens SJ Paulussen AD Stock-Myer SE Wilton LJ Jaroudi S Wells D Brown AP Handyside AH
Genet Med,16:838–845, 2014.
- Live birth after PGD with confirmation by a comprehensive approach (karyomapping) for simultaneous detection of monogenic and chromosomal disorders.
Natesan SA Handyside AH Thornhill AR Ottolini CS Sage K Summers MC Konstantinidis M Wells D Griffin DK
Reprod Biomed Online, 29:600–605, 2014.
- Clinical utilization of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation.
Wells D Kaur K Grifo J Glassner M Taylor JC Fragouli E Munné S
J Med Genet, 51:553–562, 2014.
- Next-generation sequencing: the dawn of a new era for preimplantation genetic diagnostics.
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Fertil Steril, 101:1250–1251, 2014.
- Diminished Effect of Maternal Age on Implantation After Preimplantation Genetic Diagnosis With Array Comparative Genomic Hybridization.
Harton GL Munné S Surrey M Grifo J Kaplan B McCulloh DH Griffin DK Wells D PGD Practitioners Group.
Obstet Gynecol Surv, 69:744–745, 2014.
- Non-invasive prediction of embryonic sex in cattle by metabolomic analysis of in vitro culture medium with Fourier transfrom infrared spectroscopy.
Muñoz M Uyar A Correia E Díez C Fernandez A Caamaño JN Trigal B Carrocera S Seli E Gomez E
Metabolomics, 10:443-51, 2014. *equal first authors.
- Metabolomic prediction of pregnancy viability in superovulated cattle embryos and recipients with fourier transform infrared spectroscopy
Muñoz M Uyar A Correia E Ponsart C Guyader-Joly C Martínez-Bello D Marquant-Le Guienne B Fernandez-Gonzalez A Díez C Caamaño JN Trigal B Humblot P Carrocera S Martin D Seli E Gomez E
Biomed Res Int, 2014:608579, 2014. *equal first authors.
- Prediction of pregnancy viability in bovine in vitro-produced embryos and recipient plasma with Fourier transform infrared spectroscopy.
Muñoz M Uyar A Correia E Díez C Fernandez-Gonzalez A Caamaño JN Martínez-Bello D Trigal B Humblot P Ponsart C Guyader-Joly C Carrocera S Martin D Le Guienne BM Seli E Gomez E
J Dairy Sci, 97:5497-507, 2014. *equal first authors.
- Non-invasive techniques: Embryo selection by transcriptomics, proteomics and metabolomics.
Uyar A Seli E
In: Montag M, Ed. A practical guide to select gametes and embryos. Springer/Humana Press, Berlin, German, pp 191-208, 2014.
- Clinical validation of embryo culture and selection by morphokinetic analysis: a randomized, controlled trial of the EmbryoScope.
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Fertil Steril, 102(5):1287-1294, 2014.
- Comprehensive chromosome screening (CCS) with synchronous blastocyst transfer: Time for a paradigm shift.
Scott RT Franasiak JM Forman E
Fertil Steril,102:660-1, 2014
- OMICS- current and future perspectives in reproductive medicine and technology.
Rivera R Garrido N Sota N Varghese A
Journal of Human Reproductive Sciences, 7:73-92, 2014.
- Clinical genetic testing for male factor infertility: current applications and future directions.
Hotaling J Carrell DT
Andrology, 2(3), 339-50, 2014
- Simple circumcision device: proof of concept for a single-visit, adjustable device to facilitate safe adult male circumcision.
Kadlec AO Ohlander S Hotaling J Hannick J Niederberger C Turk TM
Urolithiasis, 42(4), 323-7, 2014.
- Comparison of array comparative genomic hybridization and quantitative real-time PCR-based aneuploidy screening of blastocyst biopsies.
Capalbo A Treff N Cimadomo D Tao X Upham K Ubaldi F Rienzi L Scott RT
Eur J Hum Genet, 23:901-6, 2014
- Regulation of gene expression in the oocyte and early embryo: implications for transcriptomic and proteomic embryo assessment.
Kristiansson H Seli E
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- Selection of high potential embryos using time-lapse imaging: the era of morphokinetics.
Herrero J Meseguer M
Fertil Steril 99(4):1030-4, 2013.
- mRNA-binding protein ZFP36 is expressed in atherosclerotic lesions and reduces inflammation in human aortic endothelial cells.
Zhang H Taylor WR Joseph G Sidell N Seli E Kallen CB
Arterioscl Thromb Vasc Biol, 33:1212-20 2013.
- Metabolomic profiling of oocytes and embryos using spectroscopy: potential clinical use and pitfalls.
Sakkas D Seli E
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- Gamete and embryo assessment in assisted reproduction: emerging technologies
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- High-density SNP arrays and next generation sequencing for pre-implantation genetic diagnosis.
Handyside A Wells D
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- Transcriptomic analysis of cumulus and granulosa cells as a marker of embryo viability.
Fragouli E Wells D
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- Ergonomic deficits in robotic gynecologic oncology surgery: A need for intervention.
Craven R Franasiak JM Mosaly P Gehrig PA
J Minimal Inv Gynecol 20:648-55, 2013. †Authors contributed equally.
- The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity
Díaz-Gimeno P Ruiz-Alonso M Blesa D Bosch N Martínez-Conejero J Alamá P Garrido N Pellicer A Simón C
Fertil Steril, 99:508-517, 2013
- Assessment of sperm using mRNA microarray technology.
Garrido N García-Herrero S Meseguer M
Fertil Steril, 99:1008-1022, 2013.
- Validity and reliability of a smartphone application for the assessment of penile deformity in Peyronie's disease.
Hsi RS Hotaling J Hartzler AL Holt SK Walsh TJ
J Sex Med, 10(7), 1867-1873, 2013.
- False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3.
Mir P Rodrigo L Mercader A Buendía P Mateu E Milán-Sánchez M Peinado V Pellicer A Remohí J Simón C Rubio C
J Assist Reprod Genet, 30 (1); 143-9, 2013.
- The Paradigm of Clinical IVF is shifting: The Time to Incorporate Validated Technologies and an Enhanced Understanding of Physiology is now.
Hong KH Scott RT
J Clin Embryology, 16:104-106, 2013.
- Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases IVF implantation and delivery rates: a randomized controlled trial.
Scott RT Ferry KM Forman EJ Hong KH Scott KL Taylor D Tao X Treff NR
Fertil Steril, 100:697-703, 2013.
- Cleavage stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial.
Scott RT Ferry KM Forman EJ Zhao T Treff NR
Fertil Steril, 100:624-30, 2013.
- Comprehensive chromosome screening alters traditional morphology-based embryo selection: a prospective study of 100 consecutive cycles of planned fresh euploid blastocyst transfer.
Forman EJ Upham KM Cheng MZ Zhao T Hong KH Treff NR Scott RT
Fertil Steril, 100:718-24, 2013.
- Next-generation sequencing for preimplantation genetic diagnosis. Letter to the Editor.
Treff NR Forman EJ Scott RT
Fertil Steril, 99:e17-18, 2013
- Evaluation of targeted next-generation sequencing based preimplantation genetic diagnosis of monogenic disease.
Treff NR Fedick A Tao X Devkota B Taylor D Scott RT
Fertil Steril, 99:1377-1384, 2013.
- Four-hour quantitative real-time polymerase chain reaction– based comprehensive chromosome screening and accumulating evidence of accuracy, safety predictive values and clinical efficacy.
Treff NR Scott RT
Fertil Steril, 99: 1049-1053, 2013.
- The mRNA-binding protein Zfp36 is up-regulated by b-adrenergic stimulation and represses IL-6 production in 3T3-L1 adipocytes.
Brahma PK Murray BS Shu F Sidell N Seli E Kallen CB
Obesity, 20:40-7, 2012.
- Efficient Use of Early Obstetric Sonography in the Emergency Department Setting.
Goodman L Eichelberger KY Wolfe H Steiner AZ
J Ultrasound Med. 2012 Dec;31(12):1917-23.
- Microarray-CGH for the Assessment of Aneuploidy in Human Polar Bodies and Oocytes.
Jaroudi S Wells D
Methods in Molecular Biology, 957:267–283, 2012.
- Development of a novel synthetic oligopeptide for the detection of DNA damage in human spermatozoa.
Enciso M Pieczenik G Cohen J Wells D
Hum Reprod, 27:2254–2266, 2012.
- PGD and aneuploidy screening for 24 chromosomes by genome-wide SNP analysis: a responsible path towards greater utility.
Bisignano A Wells D Harton G Munné S
Reprod Biomed Online, 24:4–5, 2012.
- Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: a retrospective cohort study.
Meseguer M Rubio I Cruz M Basile N Marcos J Requena A
Fertil Steril, 98(6):1481-9, 2012.
- Advances in ovarian hyperstimulation in cancer patients.
Domingo J Guillén V Martínez M Rabadán S Pellicer A García-Velasco JA
US Obstetrics & Gynecology, 7:32-35, 2012
- Testing the water before swimming: satisfying the need for clinical trials of devices, media, and instruments before their use in assisted reproduction laboratories.
Garrido N Pellicer A Niederberger C
Fertil Steril, 97:245-246, 2012.
- Time-lapse technology: evaluation of embryo quality and new markers for embryo selection.
Basile N Meseguer M
Expert Rev Obstet Gynecol, 7:175-190, 2012.
- Full in vitro fertilization laboratory mechanization: toward robotic assisted reproduction?
Meseguer M Kruhne U Laursen S
Fertil Steril, 97:1277-1286, 2012.
- ¿El futuro de la reproducción son los incubadores con un sistema de time-lapse?
Tejera A Meseguer M
ASEBIR, 17: 40-41, 2012.
- Methods for comprehensive chromosome screening of oocytes and embryos: capabilities, limitations, and evidence of validity.
Scott RT
J Assist Reprod Genet, 29:381-90, 2012
- Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study.
Scott RT Ferry KM Su J Tao X Scott KL Treff NR
Fertil Steril, 97:870-875, 2012.
- Development and validation of an accurate quantitative real-time polymerase chain reaction – based assay for human blastocyst comprehensive chromosomal aneuploidy screening. Seminal Contribution.
Treff NR Tao X Ferry KM Su J Taylor D Scott RT
Fertil Steril, 97:819-824, 2012.
- How to improve IVF success rates and increase access to treatment: back to basics or more technology?
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Expert Rev Obstet Gynecol, 6:19–22, 2011.
- Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos.
Gutiérrez-Mateo C Colls P Sánchez-Garcia J Escudero T Prates R Ketterson K Wells D Munné S
Fertil Steril, 95:953–958, 2011.
- Therapeutic treatments of mtDNA diseases at the earliest stages of human development.
Chiaratti MR Meirelles FV Wells D Poulton J
Mitochondrion, 11:820–828, 2011.
- Female overweight is not associated with a higher embryo euploidy rate in first trimester miscarriages karyotyped by hysteroembryoscopy.
Bellver J Cruz F Martínez MC Ferro J Ramírez JF Pellicer A Garrido N
Fertil Steril, 96:931-933.e1, 2011.
- Cinematografía para el estudio de la calidad embrionaria. Embryoscope
Herrero J Tejera A Cruz M Meseguer M
ASEBIR, 16: 55-61, 2011.
- Aplicación de la tecnología del embryoscope para la cuentificación de la calidad ovocitaria mediante el análisis de los patrones de respiración.
Herrero J Tejera A Cruz M Meseguer M
ASEBIR, 16: 67-73, 2011.
- Live birth outcome with trophectoderm biopsy, blastocyst vitrification and SNP microarray based comprehensive chromosome screening in infertile patients.
Schoolcraft W Treff NR Stevens J Ferry K Katz-Jaffe M Scott RT
Fertil Steril, 96:638-40,2011.
- Accurate single cell 24 chromosome aneuploidy screening using whole genome amplification and single nucleotide polymorphism microarrays.
Treff NR Su J Tao X Levy B Scott RT
Fertil Steril, 94: 2017-2021, 2010.
- Mitotic expression of Spo13 alters M-phase progression and nucleolar localization of Cdc14 in budding yeast.
Varela E Schlecht U Moina A Fackenthal JD Washburn BK Niederhauser-Wiederkehr C Tsai-Pflugfelder M Primig M Gasser SM Esposito RE
Genetics, 3:841-854.2010
- Visualizing yeast chromosomes and nuclear architecture.
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- Pregnancy rates alter incubation in new time-lapse incubator (embryoscope) providing detailed information about embryo development compared to incubation in a standard incubator
Meseguer M Hilligsøe KM Pedersen KS Herrero J Tejera A Garrido N
Fertil Steril, 94(4):150, 2010.
- Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes.
Munné S Wells D Cohen J
Fertil Steril, 94:408–430, 2010.
- Improved detection of aneuploid blastocysts using a new 12-chromosome FISH test.
Munné S Fragouli E Colls P Katz-Jaffe MG Schoolcraft WB Wells D
Reprod Biomed Online, 20:92–97, 2010.
- OMICS in assisted reproduction: possibilities and pitfalls.
Seli E Robert C Sirard M-A.
Mol Hum Reprod, 16:513-30, 2010.
- Improving FISH diagnosis for preimplantation genetic aneploidy screening
Mir P Rodrigo L Mateu E Milán M Mercader A Buendía P Delgado A Pellicer A Remohí J Rubio C
Human Reprod, 25(7); 1812-7, 2010.
- Single Cell Whole Genome Amplification Technique Impacts the Accuracy of SNP Microarray Based Genotyping and Copy Number Analyses.
Treff NR Su J Tao X Northrop L Scott RT
Mol Hum Repro, 17: 335–343, 2010.
- SNP microarray based 24 chromosome aneuploidy screening demonstrates that cleavage stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts.
Northrop L Treff NR Levy B Scott RT
Mol Hum Repro, 16:590-600, 2010.
- SNP microarray based 24 chromosome aneuploidy screening is significantly more consistent than FISH.
Treff NR Levy B Su J Northrop L Tao X Scott RT
Mol Hum Repro, 16:583-9, 2010.
- Assessing the reproductive competence of individual embryos: a proposal for the validation of new "-omics" technologies.
Scott RT Treff NR
Fertil Steril, 94:791-794, 2010.
- Robust embryo identification using polar body single nucleotide polymorphism microarray based DNA fingerprinting.
Treff NR Su J Kasabwala N Tao X Miller KA Scott RT
Fertil Steril, 93: 2453-2455, 2010.
- Situación Actual de las técnicas de preservación de la Fertilidad.
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Cuadernos de Medicina Reproductiva, 15:37-47, 2009.
- Computerized analysis of normal fetal heart rate pattern throughout gestation.
Serra V Bellver J Moulden M Redman CW
Ultrasound Obstet Gynecol, 34:74-9, 2009.
- TGF-beta regulates expression of transcription factor KLF6 and its splice variants, and promotes co-operative transactivation of common target genes through a Smad3/Sp1/KLF6 interaction.
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- Lte1, Cdc14 and MEN-controlled Cdk inactivation in yeast coordinate rDNA decompaction with late telophase progression.
Varela E Shimada K Laroche T Leroy D Gasser SM
EMBO J., 28:1562-1575. 2009.
- Preventing transmission of maternally inherited mitochondrial DNA diseases.
Poulton J Kennedy S Oakeshott P Wells D
BMJ, 338:94, 2009.
- Nuevos métodos de selección embrionaria: una nueva tendencia para transferencias únicas.
Herrero J Tejera A De Los Santos MJ Garrido N Ramsing N Meseguer M
Revista Iberoamericana de Fertilidad 26 (5), 2009.
- 14-gauge angiocatheter: the assist port.
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- Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot
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Fertil Steril, 90: 77- 83, 2008
- New options in assisted reproduction technology: the Cryotop method of oocyte vitrification
Cobo A Bellver J Domingo J Pérez S Crespo J Pellicer A Remohí J
Reprod Biomed Online, 17:68-72, 2008.
- Identification and characterization of human embryonic poly(A) binding protein (ePAB).
Guzeloglu-Kayisli O Pauli SA Demir H Lalioti MD Sakkas D Seli E
Mol Hum Reprod 14:581-8, 2008.
- Alternative splicing of the mouse embryonic poly(A) binding protein (ePAB) RNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte.
Seli E Yaba A Guzeloglu-Kayisli O Lalioti MD
Mol Hum Reprod 14:393-8, 2008.
- Non-invasive metabolomic profiling of embryo culture media using proton NMR correlates with reproductive potential of embryos in women undergoing in vitro fertilization.
Seli E Botros L Sakkas D Burns DH
Fertil Steril 90:2183-9, 2008.
- Functional localization of DNA damage to pore complex bound to Slx5/8 SUMO-dependent E3 ligase
Nagai S Dubrana K Tsai-Pflufelder M Davidson M Roberts T Brown G Varela E Hediger F Gasser SM Krogan NJ
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- Unique pharmacology of KAR-2, a potential anti-cancer agent: absorption modeling and selective mitotic spindle targeting.
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Eur J Pharm Sci. 2009 Jan 31; 36(1):11-9. doi: 10.1016/j.ejps.2008.10.020. Epub 2008 Nov 5.
- Evaluation of embryo quality by Metabolomics: A new strategy to aid single embryo transfer.
Sakkas D Morita H Yamashita N Kato LO Botros L Roos P Seli E
J Mammal Ova Res. 25:26-31, 2008.
- Use of comprehensive chromosomal screening for embryo assessment: microarrays and CGH.
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Mol Hum Reprod, 14:703–710, 2008.
- Non-Invasive metabolomic profiling of human embryo culture media using Raman and near infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization
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Fertil Steril 88:1350-7, 2007.
- Future genetic and other technologies for assessing embryos.
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- Examination of the fetal brain by transabdominal three-dimensional ultrasound: potential for routine neurosonographic studies.
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Ultrasound Obstet Gynecol, 27: 503-8, 2006.
- Pulse current-mode signalling for nearly speed-of-light intrachip communcations
Jose AP Patounakis G Shepard KL
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- Active CMOS array sensor for time-resolved fluorescence detection.
Patounakis G Shepard KL Levicky R
IEEE J Solid-State Circuits, 41:2521-30. 2006
- Use of Real-Time Polymerase Chain Reaction to Measure Gene Expression in Single Cells.
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- A successful strategy for Preimplantation Genetic Diagnosis of betathalassemia and simultaneous detection of Down's syndrome using multiplex fluorescent PCR.
Piyamongkol W Vutyavanich T Piyamongkol S Wells D Kunaviktikul C Tongsong T Chaovisitsaree S Saetung R Sanguansermsri T
J Med Assoc Thai, 89:918-27, 2006.
- Crossmodal audio-visual interactions in the primary visual cortex of the visually deprived cat: a physiological and anatomical study.
Sanchez-Vives MV Nowak LG Descalzo VF García-Velasco JA Gallego R Berbel P
Prog Brain Res. 155:287-311, 2006.
- Near Speed-of-Light On-Chip Interconnects Using Pulsed Current-Mode Signaling.
Jose AP Patounakis G Shepard KL
2005 Symposium on VLSI Circuits, 108-11. 2005.
- An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos.
Seli E Lalioti MD Flaherty SM Sakkas D Terzi N Steitz JA
Proc Natl Acad Sci USA 102:367-72, 2005.
- 139. E-learning in reproductive medicine.
García-Velasco JA Schneider J
Hum Reprod. 20:569-70, 2005.
- Can antepartum computerized cardiotocography predict the evolution of intrapartum acid-base status in normal fetuses?
Bellver J Perales A Maiques V Serra V
Acta Obstet Gynecol Scand, 83:267-71, 2004.
- A Fully Integrated On-Chip DC-DC Conversion and Power Management System.
Patounakis G Li YW Shepard KL
IEEE J Solid-State Circuits, 39:443-51. 2004.
- "Isolation and characterization of two families of satellite DNA with repetitive units of 135 bp and 2.5 Kb in the ant Monomorium subopacum (Hymenoptera, Formicidae)".
Lorite P Aguilar J Carrillo J Palomeque T
Cytogen and Gen Res.;105:83-92, 2004.
- A proteomic approach to study Salmonella typhi periplasmic proteins altered by a lack of the DsbA thiol: disulfide isomerase.
Agudo D Mendoza MT Castañares C Nombela C Rotger R
Proteomics, 4(2):355-63, 2004.
- High-throughput asynchronous datapath with software-controlled voltage scaling.
Li YW Patounakis G Shepard KL Nowick SM
IEEE J Solid-State Circuits, 39:704-8. 2004
- Expression profiles of individual human oocytes using microarray technology.
Bermúdez MG Wells D Malter H Munné S Cohen J Steuerwald NM
Reprod Biomed Online, 8:325–337, 2004.
- Microarrays for Analysis and Diagnosis of Human Embryos
Wells D Bermudez MG Steuerwald N Chu L Weier U Cohen J Munne S
Fertil Steril, 80:118, 2003.
- A new follicle aspiration set is equally effective and as well tolerated as the standard needle when used in a prospective randomized trial in a large in vitro fertilization program.
Miller KA Elkind-Hirsch K Benson M Bergh P Drews M Scott RT
Fertil Steril, 81:191-3, 2004.
- Asynchronous datapath with software-controlled on-chip adaptive voltage scaling for multirate signal processing applications.
Li YW Patounakis G Jose AP Shepard KL
2003 IEEE International Symposium on Asynchronous Circuits and Systems, 216-25. 2003.
- Cytogenetics in reproductive medicine: The contribution of comparative genomic hybridization (CGH).
Wells D Levy B
BioEssays, 25:289–300, 2003.
- Whole-genome amplification.
Wells D
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- Whole genome amplification and comparative genomic hybridization (CGH).
Wells D Bermudez M
In PCR Technology: Current Innovations, 2nd edition (CRC Press, USA), p349-359. Edited by Weissensteiner T, Griffin HG, Griffin A. 2003.
- Two-step metalorganic chemical vapor deposition growth of piezoelectric ZnO thin film on SiO2/Si substrate.
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J Vac Sci Technol A, 19:1850-3. 2001.
- Analysis of SAW properties of epitaxial ZnO films grown on R-Al2O3 substrates.
Emanetoglu NW Patounakis G Liang S Gorla CR Wittstruck R Lu Y
IEEE Trans Ultrason Ferroelectr Freq Control, 48:1389-94. 2001.
- Future developments in preimplantation genetic diagnosis.
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- Influence of sequence duration and number of electrical pulses upon rabbit oocyte activation and parthenogenetic in vitro development.
Escribà MJ García-Ximénez F
Anim Reprod Sci, 59(1-2):99-107, 2000.
- Use of a variable electrical pulsing sequence in rabbit oocyte activation.
Escribà MJ García-Ximénez F
Reprod Nutr Dev, 40(3):261-9, 2000
- Aryl-alcohol oxidase protein sequence: a comparison with glucose oxidase and other FAD oxidoreductases.
Varela E Martinez AT Martinez MJ
Biochem. Biophys. Acta, 1481: 202-8. 2000.
- Southern blot screening for lignin peroxidase and aryl-alcohol oxidase genes in 30 fungal species
Varela E Martinez AT Martinez MJ
Biotechnology, 83: 245-251. 2000.
- Analysis of temperature compensated SAW modes in ZnO/SiO2/Si multilayer structures
Emanetoglu NW Patounakis G Muthukumar S Lu Y
2000 IEEE Ultrasonics Symposium, 1:325-8. 2000
- Diagnostic accuracy of sonohysterography, transvaginal sonography and hysteroscopy in uterine cavity diseases.
Soares SR Soares SR Camargos AF
Fertil Steril, 73(2):406-11, 2000
- Comparative Genomic Hybridization Reveals Extensive Variation Among Different MCF-7 Cell Stocks.
Jones C Payne J Wells D Delhanty JDA Lakhani SR Kortenkamp A
Cancer Genet Cytogenet, 117:153–158, 2000.
- Deletion and duplication of the adenomatous polyposis coli gene resulting from an interchromosomal insertion involving 5 (q22q23.3) in the father.
Hastings RJ Svennevik EC Setterfield B Wells D Delhanty JDA Mackinnon H
J Med Genet, 37:141–145, 2000.
- Electroactivation of rabbit oocytes in an hypotonic pulsing medium and parthenogenetic in vitro development without cytochalasin B-diploidizing pretreatment.
Escribà MJ García-Ximénez F
Theriogenology, 51(5):963-73, 1999.
- Molecular cloning of aryl-alcohol oxidase from the fungus Pleurotus eryngii, an enzyme involved in lignin degradation.
Varela E Martinez AT Martinez MJ
Biochem. J., 341: 113-117. 1999.
- Genomic instability in gadd45-deficient mice.
Hollander MC Sheikh MS Bulavin D Lundgren K Zhan Q Henmueller L Sheehy R Molinaro T Kim KE Tolosa E Ashwell JD Rosenberg M S-Fernandez P Morgan
Nature Genetics 23:176-184, 1999.
- Recent advances and future developments in PGD.
Harper JC Wells D
Prenat Diagn, 19:1193–1199, 1999.
- Detailed chromosomal and molecular genetic analysis of single cells by whole genome amplification and comparative genomic hybridisation.
Wells D Sherlock JK Handyside AH Delhanty JDA
Nucleic Acids Res, 27:1214–1218, 1999.
- Hysterosalpingo contrast sonography (HyCoSy) for the assessment of tubal patency
Soares SR Soares SR Cançado ML Camargos AF
Hum Reprod, 13 (11):3049-52, 1998.
- Myoadenylate deaminase deficiency myopathy in pregnancy
Bellver J Cervera J Boldó A Abad A Perales A Garcia Domenech R Román JA
Arch Gynecol Obstet. 1997;259(3):157-9.
- Ovarian reserve screening.
Sharara FI Scott RT
Infert Reprod Med Clin NA, 8:501-522. 1997.
- Use of the GnRH-agonist stimulation test in the diagnosis of ovarian remnant syndrome.
Scott RT Beatse SN Illions EH Snyder RR
J Reprod Med, 40:143-6, 1995
- Tru-Trax in vitro cervical mucus penetration test in predicting fertilization and pregnancy rates in in vitro fertilization.
Sharara FI Illions EH Coddington CC Scott RT
Human Reprod, 10:1481-5, 1995.
- Tru-trax in vitro cervical mucus penetration testing
Sharara FI Beatse SN Bailey SA Neal GK Coddington CC Scott RT
Human Reprod, 9:2027-31, 1994.
- Evaluation of the significance of a poor estradiol response during the clomiphene citrate challenge test.
Scott RT Dellinger CL Leonardi MR Illions EH Hofmann GE Navot D
Fertility News, 3:19-21.1994.
- Evaluation of the significance of a poor estradiol response during the clomiphene citrate challenge test.
Scott RT Dellinger CL Leonardi MR Illions EH Hofmann GE Navot D
Fertil Steril, 60:242-6, 1993
- A prospective evaluation of clomiphene citrate challenge test screening in the general infertility population.
Scott RT Leonardi MR Hofmann GE Illions EH Neal GS Navot D
Obstet Gynecol, 82:539-45, 1993.
- Hemizona assay: Assessment of human spermatozoa dysfunction and its correlation with in vitro fertilization results.
Oehninger S Scott RT Muasher SJ Coddington CC Acosta AA Hodgen GD
Advances in Assisted Reproductive Technologies, Edited by S Mashiach, Z Ben-Rafael, N Laufer and J Schenker. New York, Plenum Press, 515-24. 1990.
- Hemizona assay (HZA): Assessment of sperm dysfunction and prediction of in vitro fertilization (IVF) outcome.
Oehninger SC Coddington CC Scott RT Franken D acosta AA Hodgen GD.
Fertil Steril, 51:665, 1989.
- Validation of the hemizona assay (HZA) in a monkey model: Influence of oocyte maturational stages.
Oehninger SC Coddington CC Scott RT Franken D Acosta AA Hodgen GD
Fertil Steril, 51:881, 1989.
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