Desarrollo tecnológico
La tecnología en reproducción asistida ha evolucionado desde el primer recién nacido tras el primer tratamiento de FIV hace ya casi 3 décadas. Mientras que la endocrinología reproductiva y la infertilidad son campos relativamente nuevos, la tecnología en esta área de la medicina ha evolucionado a un ritmo acelerado y lo ha hecho en todas las fases del proceso. En el aspecto clínico, hemos mejorado los sistemas de monitorización de ciclos de FIV, evaluado los índices de masa corporal de las pacientes y analizado el impacto del microbioma, la dieta de los pacientes y su configuración genética. Dentro de los laboratorios de embriología, hemos observado un avance tecnológico que ha mejorado el cultivo embrionario y ha reducido la discrepancia de datos y ha ayudado a eliminar obstáculos para descubrir nuevas patologías.
El análisis de embriones mediante nuevas técnicas que estudian el ADN, el RNA, las proteínas, así como la epigenética, ha contribuido a lograr un mejor conocimiento sobre los mecanismos biológicos del desarrollo embrionario. Estos descubrimientos han originado multitud de cuestiones que se deben resolver.
Investigadores trabajando en este área
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Públicaciones en este área
- Registro Nacional de Actividad-Registro de la Sociedad Española de Fertilidad de fecundación in vitro e inyección espermática intracitoplasmática. Años 2016 y 2017
Cuevas I Prados F Pons I Montserrat de Andrés Sánchez-Castro L Lafuente R de los Santos MJ Herrero J Cabello Y Muñoz P Castel AB Canales M Castilla JA
Medicina Reproductiva y Embriología ClínicaIn press, corrected proofAvailable online 11 March 2020 - Bioengineering strategies of the uterus towards improving current investigative models and female reproductive health.
Campo H Cervelló I pellicer A
Facts Views Vis Obgyn. 2019 Mar;11(1):87-99. - Influence of Caesarean section–pregnancy interval on uterine rupture risk and IVF pregnancy rates: systematic review and mathematical modelling
Roberto Matorras Leire Berreteaga Lucía Laínz Antonia Exposito Luis Martinez
Asian J Androl. 2019 Jul 2. doi: 10.4103/aja.aja_58_19. [Epub ahead of print] - Metabolic imaging with the use of fluorescence lifetime imaging microscopy (FLIM) accurately detects mitochondrial dysfunction in mouse oocytes
Sanchez T Wang T Pedro MV Zhang M Esencan E Sakkas D Needleman D Seli E
Fertil Steril, 110(7):1387-1397. 2018. - Inter-assay variation and reproducibility of progesterone measurements during ovarian stimulation for IVF.
Lawrenz B Sibal J Garrido N Abu E Jean A Melado L Fatemi HM
PLoS One, 13(11):NA-NA, 2018. - Pores for thought: preimplantation genetic testing using a nanopore-based DNA sequencer.
Fragouli E Wells D
Fertil Steril, 110(5):853-855, 2018. - Pancreatic autoimmunity: An unknown etiology on patients with assisted reproductive techniques (ART)-recurrent reproductive failure.
Alecsandru D Barrio A Andia V Cruz E Aparicio P Serna J Cruz M Pellicer A García-Velasco JA
PLoS One, 13(10):NA-NA, 2018. - Clinical trial registry alone is not adequate: on the perception of possible endpoint switching and P-hacking.
Hill MJ Connell MT Patounakis G
Hum Reprod, 33(2):341-342, 2018. - Innovations in assisted reproductive technologies: impact on contemporary donor egg practice and future advances
Christianson MS Bellver J
Fertil Steril, 110(6):994-1002, 2018. - Autologous mitochondrial transfer as a complementary technique to intracytoplasmic sperm injection to improve embryo quality in patients undergoing in vitro fertilization-a randomized pilot study.
Labarta E De Los Santos MJ Herraiz S Escribà MJ Marzal A Buigues A Pellicer A
Fertil Steril, NA:NA -NA, 2018.
- High sperm DNA fragmentation delays human embryo kinetics when oocytes from young and healthy donors are microinjected.
Esbert M Pacheco A Soares SR Amoros D Florensa M Ballesteros A Meseguer M
Andrology, 6(5):697-706, 2018. - Anti-müllerian Hormone During Natural Cycle Presents Significant Intra and Intercycle Variations When Measured With Fully Automated Assay.
Melado L Lawrenz B Sibal J Abu E Coughlan C Navarro AT Fatemi HM
Front Endocrinol (Lausanne), 9:686-692, 2018. - Data sharing requirements: perspectives from three authors.
Barnhart KT Legro RS Scott RT
Fertil Steril, 109 (1):44-47, 2018. - Cumulus cell transcriptome profiling is not predictive of live birth after in vitro fertilization: a paired analysis of euploid sibling blastocysts.
Green KA Franasiak JM Werner MD Tao X Landis JN Scott RT Treff NR
Fertil Steril, 109(3):460-466, 2018. - Search for new molecular biomarkers to diagnose endometriosis continues.
Domínguez F
Fertil Steril, 109(4):615-616, 2018. - The Effect of Dose Adjustments in a Subsequent Cycle of Women With Suboptimal Response Following Conventional Ovarian Stimulation
Drakopoulos P Santos-Ribeiro S Bosch E García-Velasco JA Blockeel C Romito A Tournaye H Polyzos NP
Front Endocrinol (Lausanne), 9:361-361, 2018. - Cumulative live birth rates after IVF in patients with polycystic ovaries: phenotype matters.
De Vos M Pareyn S Drakopoulos P Raimundo JM Anckaert E Santos-Ribeiro S Polyzos NP Tournaye H Blockeel C
Reprod Biomed Online, 2018. - One Plus One Is Better Than Two: Cumulative Reproductive Outcomes Are Better after Two Elective Single Blastocyst Embryo Transfers Compared to OneDouble Blastocyst Embryo Transfer.
Mehta VP Patel JA Gupta RH Shah SI Banker MR
J Hum Reprod Sci, 11(2):161-168, 2018. - Preclinical Validation of a Targeted Next Generation Sequencing-based Comprehensive Chromosome Screening Methodology in Human Blastocysts.
Zimmerman RS Tao X Marin D Werner MD Hong K Lonczak A Landis J Taylor D Zhan Y Scott RT Treff NR
Mol Hum Reprod, 24:37-45, 2018 - Reduction in oxygen tension to 2% in extended culture: a more physiologic system may mean more blastocysts available for transfer.
Morin SJ
Fertil Steril, 109(6):1002-1003, 2018. - How new technical knowledge impacts clinical approach to infertile patients.
García-Velasco JA Seli E
Curr Opin Obstet Gynecol, 30(3):137-138, 2018. - Extracellular vesicles: a promising tool for assessment of embryonic competence.
Marin D Scott RT
Curr Opin Obstet Gynecol, 30(3):171-178, 2018. - Fetal sex determination in twin pregnancies using cell free fetal DNA analysis.
Milan M Mateu E Blesa D Clemente-Ciscar M Simón C
Prenat Diagn, 38(8):578-584, 2018. - Selection of preimplantation embryos using time-lapse microscopy in in vitro fertilization: State of the technology and future directions.
Aparicio-Ruiz B Romany L Meseguer M
Birth Defects Res, 110(8):648-653, 2018. - The role of mitochondrial activity in Female fertility and assisted reproductive technologies: overview and current insights.
Cecchino GN Seli E Alves da Motta EL García-Velasco JA
Reprod Biomed Online, 36(6):686-697, 2018. - Cumulus cell transcriptome profiling is not predictive of live birth after in vitro fertilization: a paired analysis of euploid sibling blastocysts.
Green KA Franasiak JM Werner MD Tao X Landis JN Scott RT Treff NR
Fertil Steril, 109(3):460-466, 2018. - Validation of a targeted next generation sequencing-based comprehensive chromosomescreening platform for detection of triploidy in human blastocysts.
Marin D Zimmerman R Tao X Zhan Y Scott RT Treff NR
Reprod Biomed Online, 36(4):388-395, 2018. - Proteomic pattern of implantative human endometrial fluid in in vitro fertilization cycles.
Matorras R Quevedo S Corral B Prieto B Exposito A Mendoza R Rabanal A Diaz-Nuñez M Ferrando M Elortza F Ametzazurra A Nagore D
Arch Gynecol Obstet, 297(6):1577-1586, 2018. - NGS Analysis of Human Embryo Culture Media Reveals miRNAs of Extra Embryonic Origin.
Sanchez-Ribas I Díaz-Gimeno P Quiñonero A Ojeda M Larreategui Z Ballesteros A Domínguez F
Reprod Sci, NA:NA-NA, 2018. - Origin and composition of cell-free DNA in spent medium from human embryo culture during preimplantation development.
Vera-Rodriguez M Diez-Juan A Jimenez-Almazan J Martínez S Navarro R Peinado V Mercader A Meseguer M Blesa D Moreno I Valbuena D Rubio C Simón C
Hum Reprod, 33(4):745-756, 2018. - 3D NIR-II Molecular Imaging Distinguishes Targeted Organs with High-Performance NIR-II Bioconjugates.
Zhu S Herraiz S Yue J Zhang M Wan H Yang Q Ma Z Wang Y He J Antaris AL Zhong Y Diao S Feng Y Zhou Y Yu K Hong G Liang Y Hsueh AJ Dai H
Adv Mater, 30(13):NA-NA, 2018. - Validation of a targeted next generation sequencing-based comprehensive chromosomescreening platform for detection of triploidy in human blastocysts.
Marin D Zimmerman R Tao X Zhan Y Scott RT Treff NR
Reprod Biomed Online, pii: S1472-6483(17)30710-1. doi: 10.1016/j.rbmo.2017.12.015, 2018. - Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the IVF population
Juneau C Kraus E Werner MD Franasiak JM Morin SJ Patounakis G Molinaro T de Ziegler D Scott RT
Fertil Steril, 108: 284-288, 2017. - Detection of mosaicism at blastocyst stage with the use of high-resolution next-generation sequencing.
Munné S Wells D
Fertil Steril, 107:1085–1091, 2017. - Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.
Zhang J Liu H Luo S Lu Z Chávez-Badiola A Liu Z Yang M Merhi Z Silber SJ Munné S Konstandinidis M Wells D Huang T
Reprod Biomed Online, 34:361-368, 2017. - Mitochondrial DNA Quantification- the devil in the detail
Wells D Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munné S Fragouli E
Hum Reprod, 32:2150–2151, 2017. - Mitochondrial DNA quantity as a biomarker for blastocyst implantation potential.
Wells D
Fertil Steril, 108:742–747, 2017. - Genome editing reveals a role for OCT4 in human embryogenesis.
Fogarty N McCarthy A Snijders KE Powell BE Kubikova N Blakeley P Lea R Elder K Wamaitha S Daesik K Maciulyte V Kleinjung J Kim J Wells D Vallier L Bertero A Turner J Niakan K
Nature, 550:67-73, 2017. - Levels of trophectoderm mitochondrial DNA do not predict the reproductive potential of sibling embryos.
Treff NR Zhan Y Tao X Olcha M Han M Rajchel J Morrison L Morin SJ Scott RT
Hum Reprod. 2017 Apr 1;32(4):954-962. doi: 10.1093/humrep/dex034. - Sperm DNA damage output parameters measured by the alkaline Comet assay and their importance
Simon L Aston KI Emery BR Hotaling J Carrell DT
LID - 10.1111/and.12608 [doi]. Andrologia, 49(2), 2017. - Mitochondrial DNA quantification as a tool for embryo viability assessment: retrospective analysis of data from single euploid blastocyst transfers.
Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Wells D Fragouli E
Hum Reprod, 32: 1282-1292, 2017 - A novel homologous model for noninvasive monitoring of endometriosis progression†.
Ferrero H Buigues A Martinez J Simón C Pellicer A Gomez R
Biol Reprod. 2017 Feb 1;96(2):302-312. doi: 10.1095/biolreprod.116.140756. - Translocations, Inversions and Other Chromosome Rearrangements.
Morin SJ Eccles J Iturriaga A Zimmerman R
Fertil Steril 2017;107(1):19-26 - Prospective study of automated versus manual annotation of early time-lapse markers in the human preimplantation embryo.
Kaser DJ Farland LV Missmer SA Racowsky C
Hum Reprod. 2017 Aug 1;32(8):1604-1611 - Clinical implications of mitochondrial DNA quantification on pregnancy outcomes: a blinded prospective non-selection study
Fragouli E McCaffrey C Ravichandran K Spath K Grifo JA Munné S Wells D
Hum Reprod, 32: 2340-2347, 2017. - The incidence and origin of segmental aneuploidy in human oocytes and preimplantation embryos.
Babariya D Fragouli E Alfarawati S Spath K Wells D
Hum Reprod, Epub, Nov 8, 2017. - Mitochondrial DNA Quantification-the devil in the detail.
Wells D Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Fragouli E Borini A Becker A Zhang J Maxwell S Grifo J Babariya D Wells D Fragouli E
Hum Reprod, 32: 2150-2151, 2017. - Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts.
Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Wells D Fragouli E
Hum Genet, 136: 805-819, 2017. - Crossing the germline: CRISPR-Cas9 and our responsibility as reproductive endocrinology and infertility physicians.
Kaser DJ Franasiak JM
J Assist Reprod Genet. 2018 Mar;35(3):399-402. doi: 10.1007/s10815-017-1075-3. Epub 2017 Oct 30. - De- and recellularization of the pig uterus: a bioengineering pilot study.
Campo H Baptista PM Lopez-Perez N Faus A Cervelló I Simón C
Biol Reprod. 2017 Jan 1;96(1):34-45. doi: 10.1095/biolreprod.116.143396. - Outcomes and Recommendations of an Indian Expert Panel for Improved Practice in Controlled Ovarian Stimulation for Assisted Reproductive Technology.
Ahemmed B Sundarapandian V Gutgutia R Balasubramanyam S Jagtap R Biliangady R Gupta P Jadhav S Satwik R Dewda PR Thakor P Esteves SC
Int J Reprod Med. 2017;2017:9451235. doi: 10.1155/2017/9451235. Epub 2017 Jan 26. - Reply: Detecting mosaicism in trophectoderm biopsies.
Capalbo A Ubaldi F Rienzi L Scott RT Treff N
Hum Reprod. 2017 Mar 1;32(3):714-715. doi: 10.1093/humrep/dew347. No abstract available. - Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the in vitro fertilization population.
Juneau C Kraus E Werner MD Franasiak JM Morin SJ Patounakis G Molinaro T De Ziegler D Scott RT
Fertil Steril. 2017 Jun 23. pii: S0015-0282(17)30421-1. doi: 10.1016/j.fertnstert.2017.05.038. [Epub ahead of print] - Enhanced techniques to "power" embryonic mitochondria research.
Scott RT
Fertil Steril. 2017 Jan;107(1):59-60. doi: 10.1016/j.fertnstert.2016.11.024. No abstract available - Embryo transfer techniques: an American Society for Reproductive Medicine survey of current Society for Assisted Reproductive Technology practices.
Toth TL Lee MS Bendikson KA Reindollar RH American Society for Reproductive Medicine Embryo Transfer Advisory Panel.
Fertil Steril. 2017 Apr;107(4):1003-1011. doi: 10.1016/j.fertnstert.2016.10.040 - Levels of trophectoderm mitochondrial DNA do not predict the reproductive potential of sibling embryos.
Treff NR Zhan Y Tao X Olcha M Han M Rajchel J Morrison L Morin SJ Scott RT
Hum Reprod. 2017 Apr 1;32(4):954-962. doi: 10.1093/humrep/dex034. - Detection of segmental aneuploidy and mosaicism in the human preimplantation embryo: technical considerations and limitations.
Treff N Franasiak JM
Fertil Steril, 107:27-31 - Frozen-thawed embryo transfers in natural cycles with spontaneous or induced ovulation: the search for the best protocol continues
Montagut M Santos-Ribeiro S De Vos M Polyzos NP Drakopoulos P Mackens S van de Vijver A Verheyen G Tournaye H Blockeel C
Hum Reprod 2016;31(12):2803-10 - IVF: progress through Technology development .
García-Velasco JA Seli E
Curr Opin Obstet Gynecol, 28:149-50, 2016. - Expanded carrier screening in an infertile population: how often is clinical decision making affected?
Franasiak JM Olcha M Bergh PA Hong KH Forman EJ Werner MD
Genet Med Off J Am Coll Med Genet 2016. - Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy.
Ravichandran K Guzman L Escudero T Zheng X Colls P Jordan A Cohen J Wells D Munné S
Reprod Biomed Online, 33:550–559, 2016. - The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.
Sermon K Capalbo A Cohen J Coonen E De Rycke M De Vos A Delhanty J Fiorentino F Gleicher N Griesinger G Grifo J Handyside A Harper J Kokkali G Mastenbroek S Meldrum D Meseguer M Montag M Munné S Rienzi L Rubio C Scott KScott RT Simón C Swain J Treff N Ubaldi F Vassena R Vermeesch J Verpoest W Wells D Geraedts J
Mol Hum Reprod, 22:845–857, 2016. - Why do euploid embryos miscarry? A case-control study comparing the rate of aneuploidy within presumed euploid embryos that resulted in miscarriage or live birth using next-generation sequencing.
Maxwell SM Colls P Hodes-Wertz B McCulloh DH McCaffrey C Wells D Munné S Grifo J
Fertil Steril, 106:1414-1419, 2016. - Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality.
Cariati F Jaroudi S Alfarawati S Raberi A Alviggi C Pivonello R Wells D
Reprod Biomed Online, 33:404–411, 2016. - Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.
Hyslop LA Blakeley P Craven L Richardson J Fogarty NM Fragouli E Lamb M Wamaitha SE Prathalingam N Zhang Q O'Keefe H Takeda Y Arizzi L Alfarawati S Tuppen HA Irving L Kalleas D Choudhary M Wells D Murdoch AP Turnbull DM Niakan KKHerbert M
Nature, 534:383–386, 2016. - Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.
Enciso M Sarasa J Xanthopoulou L Bristow S Bowles M Fragouli E Delhanty J Wells D
Hum Genet, 135:555–568, 2016. - Preimplantation genetic diagnosis: an overview and recent advances.
Ben-Nagi J Serhal P SenGupta S Doye K Wells D
Obstet Gynaecol, 18:99–106, 2016. - Current controversies in prenatal diagnosis 4: preimplantation genetic screening should be routinely offered to all preimplantation genetic diagnosis cases.
Harper J Wells D Simpson JL
Prenat Diagn, 36:25–28, 2016. - Mosaicism: “survival of the fittest” versus “no embryo left behind”.
Munné S Grifo J Wells D
Fertil Steril, 105:1146–1149, 2016. - Preimplantation genetic diagnosis for infertility.
Wells D Lewin J
In Textbook of Assisted Reproductive technologies, 5th Edition (Informa Healthcare, UK), p346-353. Edited by Gardner D, Weissman A, Howles C, Shoham Z. 2016. - Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations
Varela E Muñoz M Tejera M Ortega I Blasco M
Nature Communications, 7: 11739-11755.2016. - Mitochondrial DNA as a biomarker for in vitro fertilization (IVF) outcome
Seli E
Curr Opin Obstet Gynecol, 28:158-63, 2016. - Same-sex reproduction:Medical treatment options and psychosocial considerations.
Greenfeld D Seli E
- Effect of surgery on ovarian reserve in women with endometriomas, endometriosis and controls.
Goodman L Goldberg J Flyckt RL Gupta M Harwalkar J Falcone T
Am J Obstet Gynecol. 2016 Nov;215(5):589.e1-589.e6. - Ovarian stimulation, insemination, and contraception.
Galliano D
Fertil Steril; 105 (3): 607, 201 - First validated clinical test selects best embryos for IVF and viable pregnancies.
Fragouli E
MLO Med Lab Obs, 48: 38, 2016 - Evaluation of the antiproliferative, proapoptotic, and antiangiogenic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of leiomyoma.
García-Pascual CM Ferrero H Juarez I Martínez J Villanueva A Pozuelo-Rubio M Soengas M Tormo D Simón C Gómez R Pellicer A
Fertil Steril. 2016:105(2):529-38 - Técnicas invasivas y no invasivas en el diagnóstico de embriones humanos.
Calomarde C Carmona L Guerra I Gutiérrez D Santana A Domingo J
Rev Iberoam Fert Rep Hum, 33: 67-72, 2016. - Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios.
Agarwal A Majzoub A Esteves SC Ko E Ramasamy R Zini A
Transl Androl Urol, 5:935-950, 2016. - Spermatozoa from infertile patients exhibit differences of DNA methylation associated with spermatogenesis-related processes: an array-based analysis.
Camprubí C Salas-Huetos A Aiese-Cigliano R Godo A Pons M-C Castellano G Grossmann M Sanseverino W Martin-Subero JI Garrido N Blanco J
Reprod Biomed Online, 33:709-719, 2016. - Detection of Missing Proteins Using the PRIDE Database as a Source of Mass Spectrometry Evidence.
Garin-Muga A Odriozola L Martínez-Val A del Toro N Martínez R Molina M Cantero L Rivera R Garrido N Domínguez F Sanchez del Pino MM Vizcaíno JA Corrales FJ Segura V
J Proteome Res, 15:4101-4115, 2016. - Decreased fecundity and sperm DNA methylation patterns.
Jenkins TG Aston KI Meyer TD Hotaling J Shamsi MB Johnstone EB Cox KJ Stanford JB Porucznik CA Carrell DT
Fertil Steril, 105(1), 51-7.e1-3, 2016. - Optimization of microelectrophoresis to select highly negatively charged sperm.
Simon L Murphy K Aston KI Emery BR Hotaling J Carrell DT
J Assist Reprod Genet, 33(6), 679-88, 2016. - Microfluidics: The future of microdissection TESE?
Samuel R Badamjav O Murphy KE Patel DP Son J Gale BK Carrell DT Hotaling J
Syst Biol Reprod Med, 62(3), 161-70, 2016. - Teratozoospermia and asthenozoospermia are associated with specific epigenetic signatures.
Jenkins TG Aston KI Hotaling J Shamsi MB Simon L Carrell DT
Andrology, 4(5), 843-9, 2016. - Predictors of sperm recovery after cryopreservation in testicular cancer.
Hotaling J Patel DP Vendryes C Lopushnyan NA Presson AP Zhang C Muller CH Walsh TJ
Asian J Androl, 18(1), 35-8, 2016. - Hormone-Based Treatments in Subfertile Males. [Review].
Patel DP Chandrapal JC Hotaling J
Curr Urol Rep, 17(8), 56, 2016. - Pathophysiologic processes have an impact ot the plasma metabolomics signature of endometriosis patients.
Vicente-Muñoz S Morcillo I Puchades-Carrasco L Payá V Pellicer A Pineda-Lucena A
Fertil Steril, 106 (7): 1733-1741. E1, 2016. - A randomized and blinded comparison of qpcr and NGS based detection of aneuploidy in a cell line mixture model of blastocyst biopsy mosaicism.
Goodrich D Tao X Bohrer C Lonczak A Xing T Zimmerman R Zhan Y Scott RT Treff NR
Human Reprod, 30(2);276-83, 2015. - SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts.
Treff NR Thompson K Rafizadeh M Chow M Morrison L Tao X Garnsey H Reda CV Metzgar TL Neal S Jalas C Scott RT Forman E
J Assist Reprod Genet, 33:1115-9, 2016. - Next Generation Sequencing Based Comprehensive Chromosome Screening in Mouse Polar Bodies, Oocytes, and Embryos.
Treff NR Krisher R Tao X Garnsey H Bohrer C Silva E Landis J Taylor D Scott RT Woodruff TK Duncan FE
Biol Reprod, 94:76, 2016. - Multiple thrombophilic single nucleotide polymorphisms lack a significant effect on outcomes in fresh IVF cycles: an analysis of 1717 patients.
Patounakis G Bergh E Forman E Tao X Lonczak A Franasiak JM Treff N Scott RT
J Assist Reprod Genet, 33:67-73, 2016. - Development and validation of concurrent preimplantation genetic diagnosis for single gene disorders and comprehensive chromosomal aneuploidy screening without whole-genome amplification.
Zimmerman RS Jalas C Tao X Fedick AM Kim J Pepe RJ Northrop LE Scott RT Treff NR
Fertil Steril, 105:286-94, 2016. - Drug gastrointestinal absorption in rat: Strain and gender differences.
Oltra D Mangas-Sanjuan V González-Álvarez I Colon-Useche S González-Álvarez M Bermejo M
Eur J Pharm Sci. 2015 Oct 12;78:198-203. doi: 10.1016/j.ejps.2015.07.021. Epub 2015 Jul 28. - Variability of permeability estimation from different protocols of subculture and transport experiments in cell monolayers.
Oltra D Mangas-Sanjuan V Centelles-Sangüesa A Gonzalez-Garcia I Sanchez-Castaño G Gonzalez-Alvarez M Casabo VG Merino V Gonzalez-Alvarez I Bermejo M
J Pharmacol Toxicol Methods. 2015 Jan-Feb;71: 21-32. doi: 10.1016/j.vascn.2014.11.004. Epub 2014 Nov 26. - 24-chromosome PCR for aneuploidy screening.
Werner MD Scott RT
Curr Opin Obstet Gynecol. 2015. - Karyomapping allows preimplantation genetic diagnosis of a de-novo deletion undetectable using conventional PGD technology.
Giménez C Sarasa J Arjona C Vilamajó E Martínez-Pasarell O Wheeler K Valls G Garcia-Guixé E Wells D
Reprod Biomed Online, 31:770–775, 2015. - Validation of next-generation sequencing for comprehensive chromosome screening of embryos.
Kung A Munné S Bankowski B Coates A Wells D
Reprod Biomed Online, 31:760–769, 2015. - Routine use of next-generation sequencing for preimplantation genetic diagnosis of blastomeres obtained from embryos on day 3 in fresh in~vitro fertilization cycles.
?ukaszuk K Pukszta S Wells D Cybulska C Liss J P?óciennik ? Kuczy?ski W Zabielska J
Fertil Steril, 103:1031–1036, 2015. - Ovarian ageing
Seli E
Semin Reprod Med, 33:375-6, 2015. - Ongoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels.
Requena A Cruz M Pacheco A García-Velasco JA
Fertil Steril 2015; 104:879-883. - Endometriosis and ascites, a strategy to achieve pregnancy.
Sidiropoulou Z Setúbal A Barbosa C Soares SR
J Min Inv Gynecol, Volume 22, Issue 6, Pages 1104–1108, September-October 2015. - Introducing Larger Equipment: A Novel Method in Laparoscopic Surgery with Smaller Port Sites.
Kim S Goodman L Goldberg J
J Minim Invasive Gynecol. 2015 Nov-Dec;22(6S):S136 - The use of morphokinetics as a predictor of implantation: a multicentric study to define and validate an algorithm for embryo selection.
Basile N Vime P Florensa M Aparicio-Ruiz B García-Velasco JA Remohí J Meseguer M
Hum Reprod, 30(2):276-83, 2015. - Time-Lapse in the IVL lab: how should we assess potential benefit
Basile N Barrière P Meseguer M Fréour T
Hum Reprod, 30(5):1276, 2015 - What does morphokinetics add to embryo selection and in-vitro fertilization?
Basile N Caiazzo M Meseguer M
Curr Opin Obstet Gynecol, 27(3):193-200, 2015. - Endometrial Microbiome at the Time of Embryo Transfer: Next Generation Sequencing of the 16s Ribosomal Subunit.
Franasiak JM Werner MD Juneau C Tao X Landis J Zhan Y Treff N Scott RT
J Assist Reprod Genet 33:129-36, 2015. - s endometrial receptivity transcriptomics affected in women with endometriosis? A pilot study.
García-Velasco JA Fassbender A Ruiz Alonso M Blesa D D'Hooghe T Simón C
Reprod Biomed Online. 31:647-54, 2015. - Micro-electrophoresis: a noninvasive method of sperm selection based on membrane charge.
Simon L Murphy K Aston K Emery B Hotaling J Carrell D
Fertil Steril, 103(2), 361-6.e3, 2015. - Targeted Germline Modifications in Rats Using CRISPR/Cas9 and Spermatogonial Stem Cells.
Chapman K Medrano G Jaichander P Chaudhary Waits A Nobrega M Hotaling J Ober C Hamra F
Cell Rep, 10(11), 1828-35, 2015. - New strategy for diagnosing embryo implantation potential by combining proteomics and time-lapse technologies.
Domínguez F Meseguer M Aparicio-Ruiz B Piqueras P Quiñonero A Simón C
Fertil Steril, 104:908-914, 2015. - La tecnología del Time-lapse y su aplicación en las clínicas de reproducción asistida.
Meseguer M Motato M
ASEBIR, 20: 47-52, 2015 - The use of morphokinetics as a predictor of ?implantation: a multicentric study to define and validate an algorithm for embryo selection.
Basile N Vime P Florensa M Aparicio Ruiz B García-Velasco JA Remohí J Meseguer M
Human Reprod, 30(2);276-83, 2015. - Analysis of embryo morphokinetics, multinucleation and cleavage anomalies using continuous time-lapse monitoring in blastocyst transfer cycles.
Desai N Ploskonka S Goodman L Austin C Goldberg JM Falcone T
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Asian J Androl. 2019 Jul 2. doi: 10.4103/aja.aja_58_19. [Epub ahead of print] - Metabolic imaging with the use of fluorescence lifetime imaging microscopy (FLIM) accurately detects mitochondrial dysfunction in mouse oocytes
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Andrology, 6(5):697-706, 2018. - Anti-müllerian Hormone During Natural Cycle Presents Significant Intra and Intercycle Variations When Measured With Fully Automated Assay.
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Front Endocrinol (Lausanne), 9:686-692, 2018. - Data sharing requirements: perspectives from three authors.
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Front Endocrinol (Lausanne), 9:361-361, 2018. - Cumulative live birth rates after IVF in patients with polycystic ovaries: phenotype matters.
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J Hum Reprod Sci, 11(2):161-168, 2018. - Preclinical Validation of a Targeted Next Generation Sequencing-based Comprehensive Chromosome Screening Methodology in Human Blastocysts.
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Mol Hum Reprod, 24:37-45, 2018 - Reduction in oxygen tension to 2% in extended culture: a more physiologic system may mean more blastocysts available for transfer.
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Fertil Steril, 109(6):1002-1003, 2018. - How new technical knowledge impacts clinical approach to infertile patients.
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Reprod Sci, NA:NA-NA, 2018. - Origin and composition of cell-free DNA in spent medium from human embryo culture during preimplantation development.
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Hum Reprod, 33(4):745-756, 2018. - 3D NIR-II Molecular Imaging Distinguishes Targeted Organs with High-Performance NIR-II Bioconjugates.
Zhu S Herraiz S Yue J Zhang M Wan H Yang Q Ma Z Wang Y He J Antaris AL Zhong Y Diao S Feng Y Zhou Y Yu K Hong G Liang Y Hsueh AJ Dai H
Adv Mater, 30(13):NA-NA, 2018. - Validation of a targeted next generation sequencing-based comprehensive chromosomescreening platform for detection of triploidy in human blastocysts.
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Reprod Biomed Online, pii: S1472-6483(17)30710-1. doi: 10.1016/j.rbmo.2017.12.015, 2018. - Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the IVF population
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Fertil Steril, 108: 284-288, 2017. - Detection of mosaicism at blastocyst stage with the use of high-resolution next-generation sequencing.
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Fertil Steril, 107:1085–1091, 2017. - Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.
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Reprod Biomed Online, 34:361-368, 2017. - Mitochondrial DNA Quantification- the devil in the detail
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Fertil Steril, 108:742–747, 2017. - Genome editing reveals a role for OCT4 in human embryogenesis.
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Nature, 550:67-73, 2017. - Levels of trophectoderm mitochondrial DNA do not predict the reproductive potential of sibling embryos.
Treff NR Zhan Y Tao X Olcha M Han M Rajchel J Morrison L Morin SJ Scott RT
Hum Reprod. 2017 Apr 1;32(4):954-962. doi: 10.1093/humrep/dex034. - Sperm DNA damage output parameters measured by the alkaline Comet assay and their importance
Simon L Aston KI Emery BR Hotaling J Carrell DT
LID - 10.1111/and.12608 [doi]. Andrologia, 49(2), 2017. - Mitochondrial DNA quantification as a tool for embryo viability assessment: retrospective analysis of data from single euploid blastocyst transfers.
Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Wells D Fragouli E
Hum Reprod, 32: 1282-1292, 2017 - A novel homologous model for noninvasive monitoring of endometriosis progression†.
Ferrero H Buigues A Martinez J Simón C Pellicer A Gomez R
Biol Reprod. 2017 Feb 1;96(2):302-312. doi: 10.1095/biolreprod.116.140756. - Translocations, Inversions and Other Chromosome Rearrangements.
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Hum Reprod. 2017 Aug 1;32(8):1604-1611 - Clinical implications of mitochondrial DNA quantification on pregnancy outcomes: a blinded prospective non-selection study
Fragouli E McCaffrey C Ravichandran K Spath K Grifo JA Munné S Wells D
Hum Reprod, 32: 2340-2347, 2017. - The incidence and origin of segmental aneuploidy in human oocytes and preimplantation embryos.
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Wells D Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Fragouli E Borini A Becker A Zhang J Maxwell S Grifo J Babariya D Wells D Fragouli E
Hum Reprod, 32: 2150-2151, 2017. - Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts.
Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Wells D Fragouli E
Hum Genet, 136: 805-819, 2017. - Crossing the germline: CRISPR-Cas9 and our responsibility as reproductive endocrinology and infertility physicians.
Kaser DJ Franasiak JM
J Assist Reprod Genet. 2018 Mar;35(3):399-402. doi: 10.1007/s10815-017-1075-3. Epub 2017 Oct 30. - De- and recellularization of the pig uterus: a bioengineering pilot study.
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Biol Reprod. 2017 Jan 1;96(1):34-45. doi: 10.1095/biolreprod.116.143396. - Outcomes and Recommendations of an Indian Expert Panel for Improved Practice in Controlled Ovarian Stimulation for Assisted Reproductive Technology.
Ahemmed B Sundarapandian V Gutgutia R Balasubramanyam S Jagtap R Biliangady R Gupta P Jadhav S Satwik R Dewda PR Thakor P Esteves SC
Int J Reprod Med. 2017;2017:9451235. doi: 10.1155/2017/9451235. Epub 2017 Jan 26. - Reply: Detecting mosaicism in trophectoderm biopsies.
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Hum Reprod. 2017 Mar 1;32(3):714-715. doi: 10.1093/humrep/dew347. No abstract available. - Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the in vitro fertilization population.
Juneau C Kraus E Werner MD Franasiak JM Morin SJ Patounakis G Molinaro T De Ziegler D Scott RT
Fertil Steril. 2017 Jun 23. pii: S0015-0282(17)30421-1. doi: 10.1016/j.fertnstert.2017.05.038. [Epub ahead of print] - Enhanced techniques to "power" embryonic mitochondria research.
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Fertil Steril. 2017 Jan;107(1):59-60. doi: 10.1016/j.fertnstert.2016.11.024. No abstract available - Embryo transfer techniques: an American Society for Reproductive Medicine survey of current Society for Assisted Reproductive Technology practices.
Toth TL Lee MS Bendikson KA Reindollar RH American Society for Reproductive Medicine Embryo Transfer Advisory Panel.
Fertil Steril. 2017 Apr;107(4):1003-1011. doi: 10.1016/j.fertnstert.2016.10.040 - Levels of trophectoderm mitochondrial DNA do not predict the reproductive potential of sibling embryos.
Treff NR Zhan Y Tao X Olcha M Han M Rajchel J Morrison L Morin SJ Scott RT
Hum Reprod. 2017 Apr 1;32(4):954-962. doi: 10.1093/humrep/dex034. - Detection of segmental aneuploidy and mosaicism in the human preimplantation embryo: technical considerations and limitations.
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Fertil Steril, 107:27-31 - Frozen-thawed embryo transfers in natural cycles with spontaneous or induced ovulation: the search for the best protocol continues
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Curr Opin Obstet Gynecol, 28:149-50, 2016. - Expanded carrier screening in an infertile population: how often is clinical decision making affected?
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Genet Med Off J Am Coll Med Genet 2016. - Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy.
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Reprod Biomed Online, 33:550–559, 2016. - The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.
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Mol Hum Reprod, 22:845–857, 2016. - Why do euploid embryos miscarry? A case-control study comparing the rate of aneuploidy within presumed euploid embryos that resulted in miscarriage or live birth using next-generation sequencing.
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Fertil Steril, 106:1414-1419, 2016. - Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality.
Cariati F Jaroudi S Alfarawati S Raberi A Alviggi C Pivonello R Wells D
Reprod Biomed Online, 33:404–411, 2016. - Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.
Hyslop LA Blakeley P Craven L Richardson J Fogarty NM Fragouli E Lamb M Wamaitha SE Prathalingam N Zhang Q O'Keefe H Takeda Y Arizzi L Alfarawati S Tuppen HA Irving L Kalleas D Choudhary M Wells D Murdoch AP Turnbull DM Niakan KKHerbert M
Nature, 534:383–386, 2016. - Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.
Enciso M Sarasa J Xanthopoulou L Bristow S Bowles M Fragouli E Delhanty J Wells D
Hum Genet, 135:555–568, 2016. - Preimplantation genetic diagnosis: an overview and recent advances.
Ben-Nagi J Serhal P SenGupta S Doye K Wells D
Obstet Gynaecol, 18:99–106, 2016. - Current controversies in prenatal diagnosis 4: preimplantation genetic screening should be routinely offered to all preimplantation genetic diagnosis cases.
Harper J Wells D Simpson JL
Prenat Diagn, 36:25–28, 2016. - Mosaicism: “survival of the fittest” versus “no embryo left behind”.
Munné S Grifo J Wells D
Fertil Steril, 105:1146–1149, 2016. - Preimplantation genetic diagnosis for infertility.
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Curr Opin Obstet Gynecol, 28:158-63, 2016. - Same-sex reproduction:Medical treatment options and psychosocial considerations.
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MLO Med Lab Obs, 48: 38, 2016 - Evaluation of the antiproliferative, proapoptotic, and antiangiogenic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of leiomyoma.
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Hotaling J Patel DP Vendryes C Lopushnyan NA Presson AP Zhang C Muller CH Walsh TJ
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J Assist Reprod Genet, 33:1115-9, 2016. - Next Generation Sequencing Based Comprehensive Chromosome Screening in Mouse Polar Bodies, Oocytes, and Embryos.
Treff NR Krisher R Tao X Garnsey H Bohrer C Silva E Landis J Taylor D Scott RT Woodruff TK Duncan FE
Biol Reprod, 94:76, 2016. - Multiple thrombophilic single nucleotide polymorphisms lack a significant effect on outcomes in fresh IVF cycles: an analysis of 1717 patients.
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Fertil Steril, 105:286-94, 2016. - Drug gastrointestinal absorption in rat: Strain and gender differences.
Oltra D Mangas-Sanjuan V González-Álvarez I Colon-Useche S González-Álvarez M Bermejo M
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J Pharmacol Toxicol Methods. 2015 Jan-Feb;71: 21-32. doi: 10.1016/j.vascn.2014.11.004. Epub 2014 Nov 26. - 24-chromosome PCR for aneuploidy screening.
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Fertil Steril, 101:1250–1251, 2014. - Non-invasive prediction of embryonic sex in cattle by metabolomic analysis of in vitro culture medium with Fourier transfrom infrared spectroscopy.
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Metabolomics, 10:443-51, 2014. *equal first authors. - Metabolomic prediction of pregnancy viability in superovulated cattle embryos and recipients with fourier transform infrared spectroscopy
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Biomed Res Int, 2014:608579, 2014. *equal first authors. - Non-invasive techniques: Embryo selection by transcriptomics, proteomics and metabolomics.
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In: Montag M, Ed. A practical guide to select gametes and embryos. Springer/Humana Press, Berlin, German, pp 191-208, 2014. - Clinical validation of embryo culture and selection by morphokinetic analysis: a randomized, controlled trial of the EmbryoScope.
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Fertil Steril, 102(5):1287-1294, 2014. - Comprehensive chromosome screening (CCS) with synchronous blastocyst transfer: Time for a paradigm shift.
Scott RT Franasiak JM Forman E
Fertil Steril,102:660-1, 2014 - OMICS- current and future perspectives in reproductive medicine and technology.
Rivera R Garrido N Sota N Varghese A
Journal of Human Reproductive Sciences, 7:73-92, 2014. - Clinical genetic testing for male factor infertility: current applications and future directions.
Hotaling J Carrell DT
Andrology, 2(3), 339-50, 2014 - Simple circumcision device: proof of concept for a single-visit, adjustable device to facilitate safe adult male circumcision.
Kadlec AO Ohlander S Hotaling J Hannick J Niederberger C Turk TM
Urolithiasis, 42(4), 323-7, 2014. - Comparison of array comparative genomic hybridization and quantitative real-time PCR-based aneuploidy screening of blastocyst biopsies.
Capalbo A Treff N Cimadomo D Tao X Upham K Ubaldi F Rienzi L Scott RT
Eur J Hum Genet, 23:901-6, 2014 - Regulation of gene expression in the oocyte and early embryo: implications for transcriptomic and proteomic embryo assessment.
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In: D. Gardner, D. Sakkas, E. Seli, D. Wells eds. Emerging technologies for the assessment and diagnosis of gametes and embryos. Springer/Humana Press, Berlin, Germany, pp 163-172, 2013. - Selection of high potential embryos using time-lapse imaging: the era of morphokinetics.
Herrero J Meseguer M
Fertil Steril 99(4):1030-4, 2013. - mRNA-binding protein ZFP36 is expressed in atherosclerotic lesions and reduces inflammation in human aortic endothelial cells.
Zhang H Taylor WR Joseph G Sidell N Seli E Kallen CB
Arterioscl Thromb Vasc Biol, 33:1212-20 2013. - Metabolomic profiling of oocytes and embryos using spectroscopy: potential clinical use and pitfalls.
Sakkas D Seli E
In: D. Gardner, D. Sakkas, E. Seli, D. Wells eds. Emerging technologies for the assessment and diagnosis of gametes and embryos. Springer/Humana Press, Berlin, Germany, pp 275-280, 2013. - Gamete and embryo assessment in assisted reproduction: emerging technologies
Gardner D Sakkas D Seli E Wells D
(Springer Scientific). 2013. - High-density SNP arrays and next generation sequencing for pre-implantation genetic diagnosis.
Handyside A Wells D
In Gamete and embryo assessment in assisted reproduction: emerging technologies (Springer Scientific), p135-146. Edited by Gardner, D., Sakkas, D., Seli, E. and Wells, D. 2013. - Transcriptomic analysis of cumulus and granulosa cells as a marker of embryo viability.
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Gamete and embryo assessment in assisted reproduction: emerging technologies. p185-192. Edited by Gardner D, Sakkas D, Seli E, Wells D. (Springer Scientific). 2013. - The Textbook of Clinical Embryology
Coward Wells D
(Cambridge University Press, UK). 2013. - Ergonomic deficits in robotic gynecologic oncology surgery: A need for intervention.
Craven R Franasiak JM Mosaly P Gehrig PA
J Minimal Inv Gynecol 20:648-55, 2013. †Authors contributed equally. - The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity
Díaz-Gimeno P Ruiz-Alonso M Blesa D Bosch N Martínez-Conejero J Alamá P Garrido N Pellicer A Simón C
Fertil Steril, 99:508-517, 2013 - Assessment of sperm using mRNA microarray technology.
Garrido N García-Herrero S Meseguer M
Fertil Steril, 99:1008-1022, 2013. - Validity and reliability of a smartphone application for the assessment of penile deformity in Peyronie's disease.
Hsi RS Hotaling J Hartzler AL Holt SK Walsh TJ
J Sex Med, 10(7), 1867-1873, 2013. - False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3.
Mir P Rodrigo L Mercader A Buendía P Mateu E Milán-Sánchez M Peinado V Pellicer A Remohí J Simón C Rubio C
J Assist Reprod Genet, 30 (1); 143-9, 2013. - The Paradigm of Clinical IVF is shifting: The Time to Incorporate Validated Technologies and an Enhanced Understanding of Physiology is now.
Hong KH Scott RT
J Clin Embryology, 16:104-106, 2013. - Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases IVF implantation and delivery rates: a randomized controlled trial.
Scott RT Ferry KM Forman EJ Hong KH Scott KL Taylor D Tao X Treff NR
Fertil Steril, 100:697-703, 2013. - Cleavage stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial.
Scott RT Ferry KM Forman EJ Zhao T Treff NR
Fertil Steril, 100:624-30, 2013. - Comprehensive chromosome screening alters traditional morphology-based embryo selection: a prospective study of 100 consecutive cycles of planned fresh euploid blastocyst transfer.
Forman EJ Upham KM Cheng MZ Zhao T Hong KH Treff NR Scott RT
Fertil Steril, 100:718-24, 2013. - Incidental identification of balanced translocation carrier patients through comprehensive chromosome screening of IVF-derived blastocysts.
Treff NR Forman EJ Katz-Jaffe MG Schoolcraft WB Levy B Scott RT
J Assist Reprod Genet, 30:787-91, 2013. - Next-generation sequencing for preimplantation genetic diagnosis. Letter to the Editor.
Treff NR Forman EJ Scott RT
Fertil Steril, 99:e17-18, 2013 - Evaluation of targeted next-generation sequencing based preimplantation genetic diagnosis of monogenic disease.
Treff NR Fedick A Tao X Devkota B Taylor D Scott RT
Fertil Steril, 99:1377-1384, 2013. - Four-hour quantitative real-time polymerase chain reaction– based comprehensive chromosome screening and accumulating evidence of accuracy, safety predictive values and clinical efficacy.
Treff NR Scott RT
Fertil Steril, 99: 1049-1053, 2013. - The mRNA-binding protein Zfp36 is up-regulated by b-adrenergic stimulation and represses IL-6 production in 3T3-L1 adipocytes.
Brahma PK Murray BS Shu F Sidell N Seli E Kallen CB
Obesity, 20:40-7, 2012. - Efficient Use of Early Obstetric Sonography in the Emergency Department Setting.
Goodman L Eichelberger KY Wolfe H Steiner AZ
J Ultrasound Med. 2012 Dec;31(12):1917-23. - Microarray-CGH for the Assessment of Aneuploidy in Human Polar Bodies and Oocytes.
Jaroudi S Wells D
Methods in Molecular Biology, 957:267–283, 2012. - Development of a novel synthetic oligopeptide for the detection of DNA damage in human spermatozoa.
Enciso M Pieczenik G Cohen J Wells D
Hum Reprod, 27:2254–2266, 2012. - PGD and aneuploidy screening for 24 chromosomes by genome-wide SNP analysis: a responsible path towards greater utility.
Bisignano A Wells D Harton G Munné S
Reprod Biomed Online, 24:4–5, 2012. - Advances in ovarian hyperstimulation in cancer patients.
Domingo J Guillén V Martínez M Rabadán S Pellicer A García-Velasco JA
US Obstetrics & Gynecology, 7:32-35, 2012 - Time-lapse technology: evaluation of embryo quality and new markers for embryo selection.
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Expert Rev Obstet Gynecol, 7:175-190, 2012. - Full in vitro fertilization laboratory mechanization: toward robotic assisted reproduction?
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Fertil Steril, 97:1277-1286, 2012. - ¿El futuro de la reproducción son los incubadores con un sistema de time-lapse?
Tejera A Meseguer M
ASEBIR, 17: 40-41, 2012. - Hepatitis B virus in human oocytes and embryos.
Garrido N Bellver J Rubio C Pellicer A
Hum Reprod, 27 (4): 1227-1228, 2012. - Methods for comprehensive chromosome screening of oocytes and embryos: capabilities, limitations, and evidence of validity.
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J Assist Reprod Genet, 29:381-90, 2012 - Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study.
Scott RT Ferry KM Su J Tao X Scott KL Treff NR
Fertil Steril, 97:870-875, 2012. - Development and validation of an accurate quantitative real-time polymerase chain reaction – based assay for human blastocyst comprehensive chromosomal aneuploidy screening. Seminal Contribution.
Treff NR Tao X Ferry KM Su J Taylor D Scott RT
Fertil Steril, 97:819-824, 2012. - How to improve IVF success rates and increase access to treatment: back to basics or more technology?
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Expert Rev Obstet Gynecol, 6:19–22, 2011. - Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos.
Gutiérrez-Mateo C Colls P Sánchez-Garcia J Escudero T Prates R Ketterson K Wells D Munné S
Fertil Steril, 95:953–958, 2011. - Therapeutic treatments of mtDNA diseases at the earliest stages of human development.
Chiaratti MR Meirelles FV Wells D Poulton J
Mitochondrion, 11:820–828, 2011. - Female overweight is not associated with a higher embryo euploidy rate in first trimester miscarriages karyotyped by hysteroembryoscopy.
Bellver J Cruz F Martínez MC Ferro J Ramírez JF Pellicer A Garrido N
Fertil Steril, 96:931-933.e1, 2011. - Cinematografía para el estudio de la calidad embrionaria. Embryoscope
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ASEBIR, 16: 55-61, 2011. - Aplicación de la tecnología del embryoscope para la cuentificación de la calidad ovocitaria mediante el análisis de los patrones de respiración.
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ASEBIR, 16: 67-73, 2011. - Surgical management of tubal disease and infertility
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Obstetrics, Gynaecology and Reproductive Medicine, Vol 19, 2010. - Accurate single cell 24 chromosome aneuploidy screening using whole genome amplification and single nucleotide polymorphism microarrays.
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Fertil Steril, 94: 2017-2021, 2010. - Mitotic expression of Spo13 alters M-phase progression and nucleolar localization of Cdc14 in budding yeast.
Varela E Schlecht U Moina A Fackenthal JD Washburn BK Niederhauser-Wiederkehr C Tsai-Pflugfelder M Primig M Gasser SM Esposito RE
Genetics, 3:841-854.2010 - Visualizing yeast chromosomes and nuclear architecture.
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Mol Hum Reprod, 16:513-30, 2010. - Improving FISH diagnosis for preimplantation genetic aneploidy screening
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Human Reprod, 25(7); 1812-7, 2010. - Single Cell Whole Genome Amplification Technique Impacts the Accuracy of SNP Microarray Based Genotyping and Copy Number Analyses.
Treff NR Su J Tao X Northrop L Scott RT
Mol Hum Repro, 17: 335–343, 2010. - SNP microarray based 24 chromosome aneuploidy screening demonstrates that cleavage stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts.
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Mol Hum Repro, 16:590-600, 2010. - SNP microarray based 24 chromosome aneuploidy screening is significantly more consistent than FISH.
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Mol Hum Repro, 16:583-9, 2010. - Assessing the reproductive competence of individual embryos: a proposal for the validation of new "-omics" technologies.
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Fertil Steril, 94:791-794, 2010. - Robust embryo identification using polar body single nucleotide polymorphism microarray based DNA fingerprinting.
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Ultrasound Obstet Gynecol, 34:74-9, 2009. - TGF-beta regulates expression of transcription factor KLF6 and its splice variants, and promotes co-operative transactivation of common target genes through a Smad3/Sp1/KLF6 interaction.
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Revista Iberoamericana de Fertilidad 26 (5), 2009. - 14-gauge angiocatheter: the assist port.
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J Laparoendosc Adv Surg Tech A, 19(5), 699-701, 2009. - Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot
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Fertil Steril, 90: 77- 83, 2008 - New options in assisted reproduction technology: the Cryotop method of oocyte vitrification
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Reprod Biomed Online, 17:68-72, 2008. - Identification and characterization of human embryonic poly(A) binding protein (ePAB).
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Mol Hum Reprod 14:581-8, 2008. - Alternative splicing of the mouse embryonic poly(A) binding protein (ePAB) RNA is regulated by an exonic splicing enhancer: a model for post-transcriptional control of gene expression in the oocyte.
Seli E Yaba A Guzeloglu-Kayisli O Lalioti MD
Mol Hum Reprod 14:393-8, 2008. - Non-invasive metabolomic profiling of embryo culture media using proton NMR correlates with reproductive potential of embryos in women undergoing in vitro fertilization.
Seli E Botros L Sakkas D Burns DH
Fertil Steril 90:2183-9, 2008. - Functional localization of DNA damage to pore complex bound to Slx5/8 SUMO-dependent E3 ligase
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Science, 322: 597-602. 2008. - Unique pharmacology of KAR-2, a potential anti-cancer agent: absorption modeling and selective mitotic spindle targeting.
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J Mammal Ova Res. 25:26-31, 2008. - Human immunodeficiency type-1 virus (HIV-1) infection in serodiscordant couples (SDCs) does not have an impact on embryo quality or intracytoplasmic sperm injection (ICSI) outcome.
Barreto Melo MA Meseguer M Bellver J Remohí J Pellicer A Garrido N
Fertil Steril, 89:141-150, 2008. - Use of comprehensive chromosomal screening for embryo assessment: microarrays and CGH.
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Mol Hum Reprod, 14:703–710, 2008. - Non-Invasive metabolomic profiling of human embryo culture media using Raman and near infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization
Seli E Sakkas D Scott RT Kwok JS Rosendahl S Burns DH
Fertil Steril 88:1350-7, 2007. - Future genetic and other technologies for assessing embryos.
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In Handbook of Embryo Evaluation (Taylor and Francis, UK) p287-300. Edited by Cohen, J. and Elder, K. 2007. - Examination of the fetal brain by transabdominal three-dimensional ultrasound: potential for routine neurosonographic studies.
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Ultrasound Obstet Gynecol, 27: 503-8, 2006. - Pulse current-mode signalling for nearly speed-of-light intrachip communcations
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IEEE J Solid-State Circuits, 41:772-80. 2006 - Active CMOS array sensor for time-resolved fluorescence detection.
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IEEE J Solid-State Circuits, 41:2521-30. 2006 - Use of Real-Time Polymerase Chain Reaction to Measure Gene Expression in Single Cells.
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Prog Brain Res. 155:287-311, 2006. - Near Speed-of-Light On-Chip Interconnects Using Pulsed Current-Mode Signaling.
Jose AP Patounakis G Shepard KL
2005 Symposium on VLSI Circuits, 108-11. 2005. - An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos.
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Proc Natl Acad Sci USA 102:367-72, 2005. - 139. E-learning in reproductive medicine.
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Hum Reprod. 20:569-70, 2005. - Can antepartum computerized cardiotocography predict the evolution of intrapartum acid-base status in normal fetuses?
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Acta Obstet Gynecol Scand, 83:267-71, 2004. - A Fully Integrated On-Chip DC-DC Conversion and Power Management System.
Patounakis G Li YW Shepard KL
IEEE J Solid-State Circuits, 39:443-51. 2004. - "Isolation and characterization of two families of satellite DNA with repetitive units of 135 bp and 2.5 Kb in the ant Monomorium subopacum (Hymenoptera, Formicidae)".
Lorite P Aguilar J Carrillo J Palomeque T
Cytogen and Gen Res.;105:83-92, 2004. - A proteomic approach to study Salmonella typhi periplasmic proteins altered by a lack of the DsbA thiol: disulfide isomerase.
Agudo D Mendoza MT Castañares C Nombela C Rotger R
Proteomics, 4(2):355-63, 2004. - High-throughput asynchronous datapath with software-controlled voltage scaling.
Li YW Patounakis G Shepard KL Nowick SM
IEEE J Solid-State Circuits, 39:704-8. 2004 - Expression profiles of individual human oocytes using microarray technology.
Bermúdez MG Wells D Malter H Munné S Cohen J Steuerwald NM
Reprod Biomed Online, 8:325–337, 2004. - Microarrays for Analysis and Diagnosis of Human Embryos
Wells D Bermudez MG Steuerwald N Chu L Weier U Cohen J Munne S
Fertil Steril, 80:118, 2003. - A new follicle aspiration set is equally effective and as well tolerated as the standard needle when used in a prospective randomized trial in a large in vitro fertilization program.
Miller KA Elkind-Hirsch K Benson M Bergh P Drews M Scott RT
Fertil Steril, 81:191-3, 2004. - Asynchronous datapath with software-controlled on-chip adaptive voltage scaling for multirate signal processing applications.
Li YW Patounakis G Jose AP Shepard KL
2003 IEEE International Symposium on Asynchronous Circuits and Systems, 216-25. 2003. - Cytogenetics in reproductive medicine: The contribution of comparative genomic hybridization (CGH).
Wells D Levy B
BioEssays, 25:289–300, 2003. - Whole-genome amplification.
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In Encyclopaedia of the Human Genome. (Nature Publishing Group, UK). 2003. - Whole genome amplification and comparative genomic hybridization (CGH).
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In PCR Technology: Current Innovations, 2nd edition (CRC Press, USA), p349-359. Edited by Weissensteiner T, Griffin HG, Griffin A. 2003. - Uterine and Ovarian Function in Endometriosis.
Garrido N Pellicer A Simón C
Semin Reprod Med, 21:183-192, 2003. - The "vanishing embryo" phenomenon in an oocyte donation programme.
Rodríguez-González M Serra V García-Velasco JA Pellicer A Remohí J
Fertil Steril. 77:542-7, 2002. - Two-step metalorganic chemical vapor deposition growth of piezoelectric ZnO thin film on SiO2/Si substrate.
Muthukumar S Emanetoglu NW Patounakis G Gorla CR Liang S Lu Y
J Vac Sci Technol A, 19:1850-3. 2001. - Analysis of SAW properties of epitaxial ZnO films grown on R-Al2O3 substrates.
Emanetoglu NW Patounakis G Liang S Gorla CR Wittstruck R Lu Y
IEEE Trans Ultrason Ferroelectr Freq Control, 48:1389-94. 2001. - Future developments in preimplantation genetic diagnosis.
Harper J Wells D
In Preimplantation Genetic Diagnosis (John Wiley & Sons, UK) p241-262. Edited by Harper J, Delhanty J, Handyside A. 2001. - Human Endometrial Mucin MUC1 Is Up-Regulated by Progesterone and Down-Regulated In Vitro by the Human Blastocyst1.
Meseguer M Aplin JD Caballero-Campo P O’Connor JE Marti?n JC Remohí J Pellicer A Simo?n C
Biol Reprod, 64:590-601, 2001. - Influence of sequence duration and number of electrical pulses upon rabbit oocyte activation and parthenogenetic in vitro development.
Escribà MJ García-Ximénez F
Anim Reprod Sci, 59(1-2):99-107, 2000. - Use of a variable electrical pulsing sequence in rabbit oocyte activation.
Escribà MJ García-Ximénez F
Reprod Nutr Dev, 40(3):261-9, 2000 - Aryl-alcohol oxidase protein sequence: a comparison with glucose oxidase and other FAD oxidoreductases.
Varela E Martinez AT Martinez MJ
Biochem. Biophys. Acta, 1481: 202-8. 2000. - Southern blot screening for lignin peroxidase and aryl-alcohol oxidase genes in 30 fungal species
Varela E Martinez AT Martinez MJ
Biotechnology, 83: 245-251. 2000. - Analysis of temperature compensated SAW modes in ZnO/SiO2/Si multilayer structures
Emanetoglu NW Patounakis G Muthukumar S Lu Y
2000 IEEE Ultrasonics Symposium, 1:325-8. 2000 - Comparative Genomic Hybridization Reveals Extensive Variation Among Different MCF-7 Cell Stocks.
Jones C Payne J Wells D Delhanty JDA Lakhani SR Kortenkamp A
Cancer Genet Cytogenet, 117:153–158, 2000. - Deletion and duplication of the adenomatous polyposis coli gene resulting from an interchromosomal insertion involving 5 (q22q23.3) in the father.
Hastings RJ Svennevik EC Setterfield B Wells D Delhanty JDA Mackinnon H
J Med Genet, 37:141–145, 2000. - Electroactivation of rabbit oocytes in an hypotonic pulsing medium and parthenogenetic in vitro development without cytochalasin B-diploidizing pretreatment.
Escribà MJ García-Ximénez F
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Nature Genetics 23:176-184, 1999. - Detailed chromosomal and molecular genetic analysis of single cells by whole genome amplification and comparative genomic hybridisation.
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Nucleic Acids Res, 27:1214–1218, 1999. - Hysterosalpingo contrast sonography (HyCoSy) for the assessment of tubal patency
Soares SR Soares SR Cançado ML Camargos AF
Hum Reprod, 13 (11):3049-52, 1998. - A prospective, randomized trial of nifedipine vs. ritodrine in threatened preterm labor
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Bahado-Singh RO Oz U Isozaki T Seli E Kovanci E Hsu CD Cole L
Am J Obstet Gynecol 179:738-41, 1998. - The detection of diminished ovarian reserve in infertile women.
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Presentaciones en esta área
- Leaver M Kubikova N Tao X Jalas C Wells D O-270 A nobel long-range DNA sequencing approach improves the design of new protocols for preimplantation genetic testing of monogenic disease (PGT-M). Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2020
- Tiegs AW Tao X Whitehead CR Neal SA Osman EK Kim G Hanson BM Seli E Patounakis G Gutmann J Castlebaum A O-74 DOES PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A) HARM EMBRYOS? NO—A MULTI-CENTER, PROSPECTIVE, BLINDED, NON-SELECTION STUDY EVALUATING THE PREDICTIVE VALUE OF AN ANEUPLOID DIAGNOSIS AND IMPACT OF BIOPSY Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2019
- Bayram A De Munck N ElKhatib I Arnanz A El Damen A Abdala A Melado L Lawrenz B Fatemi H P-166: Impact of embryo replacement position (ERP) on euploid frozen embryo transfer (FET) outcomes Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ESHRE 2019
- Supramaniam P Granne I Becker C Lim L.M Venkatakrishnan R Mittal M O-234: Is ICSI ethically supported by evidence as the method of fertilisation in donor oocyte cycles, in the absence of a medical indication? Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
- Ferrero H Corachán A Quiñonero A Carbajo-García C Alamá P Tejera A Taboas E Muñoz E Pellicer A Domínguez F NGS of Oocytes from Endometriosis Patients Reveals a Differential Transcriptomic Pattern Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2019
- Gonzalez-Martin R Quiñonero A Pérez S Salsano S Domínguez F Acute DEHP Exposure in Endometrial Epithelial Cells Does Not Phenocopy the Alterations Described in Endometriosis. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
- Gonzalez-Martin R Telez-Plaza M Domínguez F Association of Blood Cadmium and Lead Levels with Reproductive Lifespan Among Postmenopausal Women: NHANES 2005-2014. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
- Sánchez-de-Puerta I González-García M Varela E Mor A Implications of Telomere Biology in Female Reproductive Aging Using the SAMP8 Mouse Model Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
- Salsano S Quiñonero A Yañez-Mo Gómez A Pérez S Dominguez F Novel Non-Classic Progesterone P4 Receptor PGRMC1 Interactions and Functionality Reveal a Key Role Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
- Duan J Jiang Z Seli E Tian X Wang T Zhang M Evaluating mitochondrial stress response gene clpp-regulated dna methylome dynamics in female reproductive aging Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2018
- Rajchel J Vega C Garnsey HM Scott I Jalas C Tao X Scott RT Validation of simultaneous diagnosis of single gene disorder (sgd) and next generation sequencing (ngs) - based comprehensive chromosomal aneuploidy screening (ccs) from a single trophectoderm (te) biopsy Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
- Morin SJ Wang T Tao X Earnhardt M Seli E Scott RT Ultra-low oxygen (o2) tension after day 3 of in vitro development does not alter blastocyst transcriptome: a comparison of 2% versus 5% o2 tension in extended culture Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
- Kim G Morin SJ Patounakis G Juneau C Neal SA Abc trial: appraisal of body content. Frozen embryo cycles are not impacted by the negative effects of obesity seen in fresh cycles Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
- Tiegs W Tao X Landis J Rajchel J Bedard JL Seli E Wells D Fragouli E Scott RT Evaluation of sperm mitochondrial dna copy number as a predictor of in vitro fertilization/intracytoplasmic sperm injection (ivf/icsi) cycle outcomes in a large infertile population Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
- Castillo LM Buigues A Pellegrini L Rossi V Klinger F Pellicer A Herraiz S LH gonadoprotection against ovarian damage induced by alkytaing drugs in adult mouse ovaries. Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ESHRE 2018
- Devesa A Sebastian-Leon P Garcia-Garcia F Arnau V Pellicer A Diaz-Gimeno P Functional genomic meta-analysis identifies similarities between endometrial-related subfertilities Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Staicu FD Martinez-Soto JC Matas C Protein kinase A modulation by nitric oxide during human sperm capacitation Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Salsano S Quiñonero A Pérez S González-Ravina C Simón C Dominguez F Non-classical progesterone signaling may be sufficient to induce decidualization in Human Endometrial Stromal Cells (ESC) Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
- Cecchino G Cerrillo M Cruz M Garcia Velasco J Retrospective analysis of DuoStim cycles shows similar overall performance and oocyte quality between follicular and luteal phase stimulation Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
- Fatemi H Griesinger G Teal V Polyzos N Bosch E Johnson B Dos Santos S Garcia Velasco J Stoop D FSH exposure between day 8 and day of Hcg administration is an independent predictor of serum progesterone rise Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
- Perez S Salsano S Quiñonero A Dominguez F Phytoestrogens (Soy-Derived Metabolites) May Act Like Endometrial Disruptors Altering Decidualization of Human Endometrial Stromal Cells Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2018
- Colombo S Franasiak JM Kaser DJ Molinaro T Bergh PA Significance of endometrial lining decrease after progesterone start in synthetic frozen embryo transfer (FET) cycles Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2017