Receptividad endometrial
La interacción entre el embrión y la mucosa que recubre el interior del útero (el endometrio) es fundamental para lograr la implantación, el desarrollo de la placenta y, en última instancia, para conseguir un embarazo viable y un recién nacido. Esta interacción es un proceso complejo en el que todavía quedan cuestiones por comprender.
El momento exacto en el que se produce dicha interacción durante la ventana de implantación, que conllevará a que se produzca una sincronía entre embrión y endometrio, no había sido considerado hasta el momento como un factor crítico que influye en los resultados del tratamiento. Tanto las condiciones ambientales del laboratorio de FIV como el desarrollo embrionario, así como la gestión médica de la estimulación ovárica y la preparación endometrial, influyen en todo el proceso. El trabajo en este campo busca profundizar en el estudio fisiológico y patológico del proceso con el fin de obtener un bebé sano por transferencia embrionaria.
Investigadores trabajando en este área
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Públicaciones en este área
- Different Endometrial Receptivity in Each Hemiuterus of a Woman with Uterus Didelphys and Previous Failed Embryo Transfers.
Carranza F González-Ravina A Blasco V Fernández-Sánchez M
J Hum Reprod Sci, 11(3):297-299, 2018.
- Implantation failure of endometrial origin: what is new?
Bellver J Simón C
Curr Opin Obstet Gynecol, 30(4):229-236, 2018.
- Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure.
Sebastian-Leon P Garrido N Remohí J Pellicer A Díaz-Gimeno P
Hum Reprod, 33(4):626-635, 2018.
- Human Endometrial Reconstitution From Somatic Stem Cells: The Importance of Niche-Like Cells.
Lopez-Perez N Gil-Sanchis C Ferrero H Faus A Diaz A Pellicer A Cervelló I Simón C
Reprod Sci, NA:NA-NA, 2018.
- Proteomic pattern of implantative human endometrial fluid in in vitro fertilization cycles.
Matorras R Quevedo S Corral B Prieto B Exposito A Mendoza R Rabanal A Diaz-Nuñez M Ferrando M Elortza F Ametzazurra A Nagore D
Arch Gynecol Obstet, 297(6):1577-1586, 2018.
- Natural killer cells in reproduction: helpful, harmful, or misunderstood?
Morin SJ Franasiak JM
Consider This: Fertility and Sterility Dialog. May 2017.
- Mu opioid receptor in the human endometrium: dynamics of its expression and localization during the menstrual cycle.
Totorikaguena L Olabarrieta E Matorras R Alonso E Agirregoitia E Agirregoitia N
Fertil Steril, 107:1070-1077, 2017.
- Role of Stro1+/CD44+ stem cells in myometrial physiology and uterine remodeling during pregnancy.
Mas A Prusinski L Yang Q Díaz-Gimeno P Stone L Diamond MP Simón C Al-Hendy A
Biol Reprod. 2017 Jan 1;96(1):70-80. doi: 10.1095/biolreprod.116.14346
- Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology.
Garrido-Gomez T Domínguez F Quiñonero A Díaz-Gimeno P Kapidzic M Gormley M Ona K Padilla-Iserte P McMaster M Genbacev O Perales A Fisher SJ Simón C
Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8468-E8477. doi: 10.1073/pnas.1706546114. Epub 2017 Sep 18
- Impact of Endometrial Preparation Protocols for Frozen Embryo Transfer on Live Birth Rates.
Cerrillo M Herrero L Guillen A Mayoral M García-Velasco JA
Rambam Maimonides Med J. 2017 Apr 28;8(2). doi: 10.5041/RMMJ.10297.
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Presentaciones en esta área
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Bellver J Lathi RB Labarta E Vidal C Giles J Cabanillas S Marzal A Galliano D Marin C Ruiz-Alonso M Simón C Valbuena D Obesity affects endometrial receptivity by inducing a displacement of the personalized woi that after correction by personalized embryo transfer normalize clinical results Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ASRM 2018
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Alecsandru D Iglesias C Pacheco A Barrio A Garrido N Garcia Velasco J HLA-C haplotypes distribution among gametes donors in our population Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
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Devesa A Sebastian-Leon P Garcia-Garcia F Arnau V Pellicer A Diaz-Gimeno P
Functional genomic meta-analysis identifies similarities between endometrial-related subfertilities
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Salsano S Quiñonero A Pérez S González-Ravina C Simón C Dominguez F
Non-classical progesterone signaling may be sufficient to induce decidualization in Human Endometrial Stromal Cells (ESC)
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Azkargorta M Escobes I Lloro I Osinalde N Corral B Exposito A Prieto B Elortza F Matorras R
Differential proteomic analysis of endometrial fluid suggets increased inflammation and extracellular matrix remodeling in non-implantative IVF cycles
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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López-Pérez N Santamaría X Díaz-Gimeno P Sebastian-Leon P Faus A Remohí J Pellicer A Simón C Cervelló I Stem Cell-Secreted Paracrine Factors in Human Endometrial Regeneration Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
SRI 2018
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Perez S Salsano S Quiñonero A Dominguez F
Phytoestrogens (Soy-Derived Metabolites) May Act Like Endometrial Disruptors Altering Decidualization of Human Endometrial Stromal Cells
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
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Colombo S Franasiak JM Kaser DJ Molinaro T Bergh PA Significance of endometrial lining decrease after progesterone start in synthetic frozen embryo transfer (FET) cycles Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2017
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Alecsandru D Pacheco A Garrido N Barrio A Aparicio P Pellicer A Garcia Velasco J Live birth rate after oocyte donation is influenced by donor HLA-C: one step beyond conventional markers of success Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017
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Diaz-Gimeno P Sebastian-Leon P Remohí J Garrido N Pellicer A
New transcriptomic insight improves endometrial Recurrent Implantation Failure (RIF) diagnosis and distinguishes clearly between a displaced and a disrupted Window Of Implantation (WOI)
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Grasso A Navarro R Moreno I Herrero M Alama A Vilella F Simon C
Differential microRNA profile in the endometrial fluid (EF)in natural cycles, HRT, and controlled ovarian stimulation (COS) triggered with hCG (COS+hCG) or GnRHa (COS+GnRHa)
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Laisk T Suhorutshenko M Kukushkina V Velthut-Meikas A Magi R Peters M Altmäe S Krjut?kov K Martinez-Blanch JF Codoñer FM Vilella F Simon C Salumets A
Novel endometrial receptivity markers detected in largescale RNA-sequencing study combining samples from different populations
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Santamaría Costa X Cabanillas S Arbona C Cervelló I Raga F Ferro J Palmero J Remohí J Pellicer A Simon C
Stem cell treatment for endometrial pathologies
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Santamaría X Cervelló I Cabanillas S Arbona C Raga F Ferro J Palmero J Remohí J Pellicer A Simon C
Human Reproduction keynote lecture - Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Balaguer N Moreno I Herrero M González-Montfort M Simón C Vilella F Maternal MiR-30d deficiency is associated with defects in endometrial receptivity, embryonic implantation and fetal development Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
SRI 2017
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Bolumart D Moreno I Herrero M Cabanillas S Vilella F Simón C
Extracellular vesicles secreted by the human endometrium contain specific DNA sequences that are uptaken by Murine Embryos
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Díaz-Gimeno P Ruiz-Alonso M Sebastián-León P Singh V Pellicer A Valbuena D Simón C
Improvement of the endometrial receptivity signature reveals a possible maternal origin of biochemical pregnancies
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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López-Pérez N Gil-Sanchis C Faus A Diaz A Campo H Pellicer A Cervelló I Carlos Simón
Human endometrial reconstitution using W5C5, ICAM1 cells and side population cell lines in a xenograft model
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Salsano S Quiñonero A Pérez S Simón C Domínguez F
Non Classical Progesterone Receptor and SERPINE1mRNA (PGRMC1) Binding Protein (SERBP1) Interaction Influences the Human Decidualization Process
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Sebastian-León P Conesa A Arnau V Remohí J Pellicer A Simón C Diaz-Gimeno P
Network biology of menstrual cycle to understand the key drivers of endometrial receptivity
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Vilella F Behr B Reddy V Wang W Navarro R Jiménez J Quake S C Simón
Maternal endometrial hsa-miR-30d is taken up by the human blastocyst and induces transcriptional modifications
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation