Receptividad endometrial
La interacción entre el embrión y la mucosa que recubre el interior del útero (el endometrio) es fundamental para lograr la implantación, el desarrollo de la placenta y, en última instancia, para conseguir un embarazo viable y un recién nacido. Esta interacción es un proceso complejo en el que todavía quedan cuestiones por comprender.
El momento exacto en el que se produce dicha interacción durante la ventana de implantación, que conllevará a que se produzca una sincronía entre embrión y endometrio, no había sido considerado hasta el momento como un factor crítico que influye en los resultados del tratamiento. Tanto las condiciones ambientales del laboratorio de FIV como el desarrollo embrionario, así como la gestión médica de la estimulación ovárica y la preparación endometrial, influyen en todo el proceso. El trabajo en este campo busca profundizar en el estudio fisiológico y patológico del proceso con el fin de obtener un bebé sano por transferencia embrionaria.
Investigadores trabajando en este área
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Públicaciones en este área
- The lipidome of endometrial fluid differs between implantative and non-implantative IVF cycles.
Matorras R Martinez-Arranz I Arretxe E Iruarruzaga-Lejarreta M Corral B Ibañez-Perez J Exposito A Prieto B Elortza F Alonso C
J Assist Reprod Genet. 2019 Dec 21. doi: 10.1007/s10815-019-01670-z. [Epub ahead of print]
- Endometrial receptivity and implantation in women with previous failed embryo transfers: to scratch or not to scratch?
Galliano D
Fertil Steril. 2019 Dec;112(6):1043. doi: 10.1016/j.fertnstert.2019.09.008. No abstract available.
- Endometrial liquid biopsy provides a miRNA roadmap of the secretory phase of the human endometrium.
Grasso A Navarro R Balaguer N Moreno I Alama P Jimenez J Simon C Villela F
J Clin Endocrinol Metab. 2019 Oct 29. pii: dgz146. doi: 10.1210/clinem/dgz146. [Epub ahead of print]
- The seminal microbiome in health and disease.
Altmae S Franasiak JM Mandar R
Nat Rev Urol. 2019 Nov 15. doi: 10.1038/s41585-019-0250-y. [Epub ahead of print] Review.
- The endometrial immune environment of women with endometriosis.
Vallvé-Juanico J Houshdaran S Giudice LC
Hum Reprod Update. 2019 Sep 11;25(5):564-591. doi: 10.1093/humupd/dmz018.
- Phytoestrogen exposure alters endometrial stromal cells and interferes with decidualization signaling.
Salsano S Pérez-Debén S Quiñonero A González-Martín R Domínguez F
Fertil Steril. 2019 Jul 29. pii: S0015-0282(19)30547-3. doi: 10.1016/j.fertnstert.2019.06.014. [Epub ahead of print]
- Inhibition of KIF20A by BKS0349 reduces endometriotic lesions in a xenograft mouse model.
Ferrero H Corachán A Quiñonero A Bougeret C Pouletty P Pellicer A Domínguez F
Mol Hum Reprod. 2019 Jul 31. pii: gaz044. doi: 10.1093/molehr/gaz044. [Epub ahead of print]
- Chronic endometritis is associated with an altered microbiome, but what about treatment and clinical outcomes?
Franasiak JM
Fertil Steril. 2019 Jul 29. pii: S0015-0282(19)30552-7. doi: 10.1016/j.fertnstert.2019.06.019. [Epub ahead of print] No abstract available.
- Tissue-specific decellularized endometrial substratum mimicking different physiological conditions influences in vitro embryo development in a rabbit model.
Campo H García-Domínguez X López-Martínez S Faus A Salvador Vicente Antón J Marco-Jiménez F Cervelló I
Acta Biomater. 2019 Mar 5. pii: S1742-7061(19)30170-9. doi: 10.1016/j.actbio.2019.03.004. [Epub ahead of print]
- Obstetrical complications of thin endometrium in assisted reproductive technologies: a systematic review.
Mouhayar Y Franasiak JM Sharara FI
J Assist Reprod Genet. 2019 Jan 25. doi: 10.1007/s10815-019-01407-y. [Epub ahead of print] Review
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Presentaciones en esta área
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Meseguer M Alegre L Bori L Pellicer A Maor R Seidman DS Gilboa D P-125 Automated halo identification : a novel predictive feature for IVF success identified through an artificial intelligence (AI) algorithm Presented at 75th American Society of Reproductive Medicine Scientific Congress
ASRM 2019
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Cecchino G Pacheco A
O-81 THE EFFECT OF AGE ON BIOENERGETICS OF HUMAN GRANULOSA CELLS
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Yang M Tao X Zhao T Scott RT Seli E
P-390 ANALYSIS OF ACCESSIBLE CHROMATIN LANDSCAPE IN THE INNER CELL MASS AND TROPHECTODERM OF HUMAN BLASTOCYSTS USING ATAC-SEQ
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Devesa Peiro A Sebastian-Leon P Pellicer A Diaz Gimeno P P-298: Biomarker discovery associated with endometrial-related conditions is biased by the menstrual cycle effect in the transcriptomic analysis Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology
ESHRE 2019
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Bellver J Lathi RB Labarta E Vidal C Giles J Cabanillas S Marzal A Galliano D Marin C Ruiz-Alonso M Simón C Valbuena D Obesity affects endometrial receptivity by inducing a displacement of the personalized woi that after correction by personalized embryo transfer normalize clinical results Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ASRM 2018
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Alecsandru D Iglesias C Pacheco A Barrio A Garrido N Garcia Velasco J HLA-C haplotypes distribution among gametes donors in our population Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
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Devesa A Sebastian-Leon P Garcia-Garcia F Arnau V Pellicer A Diaz-Gimeno P
Functional genomic meta-analysis identifies similarities between endometrial-related subfertilities
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Salsano S Quiñonero A Pérez S González-Ravina C Simón C Dominguez F
Non-classical progesterone signaling may be sufficient to induce decidualization in Human Endometrial Stromal Cells (ESC)
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Azkargorta M Escobes I Lloro I Osinalde N Corral B Exposito A Prieto B Elortza F Matorras R
Differential proteomic analysis of endometrial fluid suggets increased inflammation and extracellular matrix remodeling in non-implantative IVF cycles
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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López-Pérez N Santamaría X Díaz-Gimeno P Sebastian-Leon P Faus A Remohí J Pellicer A Simón C Cervelló I Stem Cell-Secreted Paracrine Factors in Human Endometrial Regeneration Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
SRI 2018
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Perez S Salsano S Quiñonero A Dominguez F
Phytoestrogens (Soy-Derived Metabolites) May Act Like Endometrial Disruptors Altering Decidualization of Human Endometrial Stromal Cells
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
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Colombo S Franasiak JM Kaser DJ Molinaro T Bergh PA Significance of endometrial lining decrease after progesterone start in synthetic frozen embryo transfer (FET) cycles Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2017
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Alecsandru D Pacheco A Garrido N Barrio A Aparicio P Pellicer A Garcia Velasco J Live birth rate after oocyte donation is influenced by donor HLA-C: one step beyond conventional markers of success Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017
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Diaz-Gimeno P Sebastian-Leon P Remohí J Garrido N Pellicer A
New transcriptomic insight improves endometrial Recurrent Implantation Failure (RIF) diagnosis and distinguishes clearly between a displaced and a disrupted Window Of Implantation (WOI)
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Grasso A Navarro R Moreno I Herrero M Alama A Vilella F Simon C
Differential microRNA profile in the endometrial fluid (EF)in natural cycles, HRT, and controlled ovarian stimulation (COS) triggered with hCG (COS+hCG) or GnRHa (COS+GnRHa)
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Laisk T Suhorutshenko M Kukushkina V Velthut-Meikas A Magi R Peters M Altmäe S Krjut?kov K Martinez-Blanch JF Codoñer FM Vilella F Simon C Salumets A
Novel endometrial receptivity markers detected in largescale RNA-sequencing study combining samples from different populations
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Santamaría Costa X Cabanillas S Arbona C Cervelló I Raga F Ferro J Palmero J Remohí J Pellicer A Simon C
Stem cell treatment for endometrial pathologies
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Santamaría X Cervelló I Cabanillas S Arbona C Raga F Ferro J Palmero J Remohí J Pellicer A Simon C
Human Reproduction keynote lecture - Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Balaguer N Moreno I Herrero M González-Montfort M Simón C Vilella F Maternal MiR-30d deficiency is associated with defects in endometrial receptivity, embryonic implantation and fetal development Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
SRI 2017
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Bolumart D Moreno I Herrero M Cabanillas S Vilella F Simón C
Extracellular vesicles secreted by the human endometrium contain specific DNA sequences that are uptaken by Murine Embryos
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Díaz-Gimeno P Ruiz-Alonso M Sebastián-León P Singh V Pellicer A Valbuena D Simón C
Improvement of the endometrial receptivity signature reveals a possible maternal origin of biochemical pregnancies
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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López-Pérez N Gil-Sanchis C Faus A Diaz A Campo H Pellicer A Cervelló I Carlos Simón
Human endometrial reconstitution using W5C5, ICAM1 cells and side population cell lines in a xenograft model
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Salsano S Quiñonero A Pérez S Simón C Domínguez F
Non Classical Progesterone Receptor and SERPINE1mRNA (PGRMC1) Binding Protein (SERBP1) Interaction Influences the Human Decidualization Process
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Sebastian-León P Conesa A Arnau V Remohí J Pellicer A Simón C Diaz-Gimeno P
Network biology of menstrual cycle to understand the key drivers of endometrial receptivity
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Vilella F Behr B Reddy V Wang W Navarro R Jiménez J Quake S C Simón
Maternal endometrial hsa-miR-30d is taken up by the human blastocyst and induces transcriptional modifications
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation