Receptividad endometrial
La interacción entre el embrión y la mucosa que recubre el interior del útero (el endometrio) es fundamental para lograr la implantación, el desarrollo de la placenta y, en última instancia, para conseguir un embarazo viable y un recién nacido. Esta interacción es un proceso complejo en el que todavía quedan cuestiones por comprender.
El momento exacto en el que se produce dicha interacción durante la ventana de implantación, que conllevará a que se produzca una sincronía entre embrión y endometrio, no había sido considerado hasta el momento como un factor crítico que influye en los resultados del tratamiento. Tanto las condiciones ambientales del laboratorio de FIV como el desarrollo embrionario, así como la gestión médica de la estimulación ovárica y la preparación endometrial, influyen en todo el proceso. El trabajo en este campo busca profundizar en el estudio fisiológico y patológico del proceso con el fin de obtener un bebé sano por transferencia embrionaria.
Investigadores trabajando en este área
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Públicaciones en este área
- Bacterial Vaginosis and Its Association with Infertility, Endometritis, and Pelvic Inflammatory Disease.
Ravel J Moreno I Simón C
Am J Obstet Gynecol. 2020 Oct 19:S0002-9378(20)31193-5. doi: 10.1016/j.ajog.2020.10.019. Online ahead of print.
- Corrigendum. Do we need to measure progesterone in oocyte donation cycles? A retrospective analysis evaluating cumulative live birth rates and embryo quality.
Racca A De Munck N Santos-Ribeiro S Drakopoulos P Errazuriz J Galvao A Popovic-Todorovic B Mackens S De Vos M Verheyen G Tournaye H Blockeel C
Hum Reprod. 2020 Apr 28;35(4):1008. doi: 10.1093/humrep/deaa038.
- Tacrolimus Improves the Implantation Rate in Patients with Elevated Th1/2 Helper Cell Ratio and Repeated Implantation Failure (RIF).
Bahrami-Asl Z Farzadi L Fattahi A Yousefi M Quinonero A Hakimi P Latifi Z Nejabati HR Ghasemnejad T Sadigh AR Heidari MH Nouri M MG N Dominguez F
Geburtshilfe Frauenheilkd. 2020 Aug;80(8):851-862. doi: 10.1055/a-1056-3148. Epub 2020 Aug 14.
- The reproductive microbiome - clinical practice recommendations for fertility specialists.
García-Velasco JA Budding D Campe H Malfertheiner SF Hamamah S Santjohanser C Schuppe-Koistinen I Nielsen HS Vieira-Silva S Laven J
Reprod Biomed Online. 2020 Jun 27:S1472-6483(20)30339-4. doi: 10.1016/j.rbmo.2020.06.014. Online ahead of print.
- SARS-CoV-2 infection risk assessment in the endometrium: viral infection-related gene expression across the menstrual cycle
Henarejos-Castillo I Sebastian-Leon P Devesa-Peiro A Pellicer A Patricia Diaz-Gimeno
Fertil Steril. 2020 Aug;114(2):223-232. doi: 10.1016/j.fertnstert.2020.06.026. Epub 2020 Jun 17.
- Should Vanishing Twin Pregnancies Be Systematically Excluded From Cell-Free Foetal Dna Testing?
Balaguer N Mateu-Brull E Serrra V Simón C Milán M
Prenat Diagn. 2020 Aug 24. doi: 10.1002/pd.5817. Online ahead of print.
- Comparison of different sources of platelet-rich plasma as treatment option for infertility-causing endometrial pathologies
Miguel–Gómez L López-Martínez S Campo H Francés-Herrero E Amparo Faus Ana Díaz Pellicer A Domínguez F Cervelló I
Fertility and SterilityIn press, corrected proofAvailable online 24 August 2020
- Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle.
Wang W Vilella F Alama P Moreno I Mignardi M Isakova A Pan W Simon C Quake SR
Nat Med. 2020 Sep 14. doi: 10.1038/s41591-020-1040-z. Online ahead of print.
- Evaluation of the endometrial receptivity assay and the preimplantation genetic test for aneuploidy in overcoming recurrent implantation failure.
Cozzolino M Diaz-Gimeno P Pellicer A Garrido N
J Assist Reprod Genet. 2020 Sep 24. doi: 10.1007/s10815-020-01948-7. Online ahead of print.
- Serum progesterone levels on day of embryo transfer in frozen embryo transfer cycles-the truth lies in the detail.
Alsbjerg B Labarta E Humaidan P
J Assist Reprod Genet. 2020 Jun 12. doi: 10.1007/s10815-020-01851-1. Online ahead of print.
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Presentaciones en esta área
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Gill P Kim JG Bergh PA Scott RT P-349 ULTRASOUND IMAGING PREDICTS ENDOMETRIAL RECEPTIVITY – A DECREASE IN ENDOMETRIAL THICKNESS (COMPACTION) PRIOR TO EMBRYO TRANSFER IS ASSOCIATED WITH AN INCREASE IN CLINICAL PREGNANCY RATE IN SYNTHETIC FROZEN EUPLOID IVF CYCLES Presented at 76th American Society of Reproductive Medicine Scientific Congress
ASRM2020
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Klimczak AM Herlihy NS Scott CS Hanson BM Kim JG Tiegs AW Osman EK Titus S Seli E Scott RT
P-463 ENDOMETRIAL BCL6 EXPRESSION IS NOT ASSOCIATED WITH IMPLANTATION OUTCOMES
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Herlihy NS Titus S Scott CS Klimczak AM Hanson BM Kim JG Tiegs AW Osman EK Seli E Scott RT
P-256 ENDOMETRIAL STAINING FOR CD138 AS A MARKER OF CHRONIC ENDOMETRITIS DOES NOT PREDICT FAILED IMPLANTATION
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Herlihy NS Tao X Zhan Y Chaim Jalas Klimczak AM Hanson BM Kim JG Osman EK Tiegs AW Seli E Scott RT Franasiak J
P-465 INCREASING MICROBIAL DIVERSITY AND LACTOBACILLUS DOMINANCE OF GENITOURINARY, GASTROINTESTINAL, AND REPRODUCTIVE TRACTS DO NOT ASSOCIATE WITH REPRODUCTIVE OUTCOMES AFTER EUPLOID SINGLE EMBRYO TRANSFER
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Ortega I Alvarez de la Fuente A Sonia Matey Elizabet Henzenn Cruz M Pacheco A Antoni Duleba Garcia-Velasco JA
P-854 RESVERATROL FOR PREVENTING OVARIAN HYPERSTIMULATION SYNDROME IN WOMEN AT RISK UNDERGOING EGG DONATION: A RANDOMIZED CONTROLLED STUDY
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Gonzalez-Martin R Palomar A Pérez-Debén S Quiñonero A Dominguez F F-209 Mercury Disturbs Reproductive Functions of Primary Endometrial Stromal Cells (ESC). Presented at the 67th Annual Meeting of the Society for Reproductive Investigation
SRI 2020
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Maria Sanchez-Reyes J Spath K Sebastian-Leon P Wells D Diaz-Gimeno P
S-214 Determination of Optimal Housekeeping Genes for Transcriptional Study of the Endometrium
Presented at the 67th Annual Meeting of the Society for Reproductive Investigation
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Devesa-Peiro A Sebastian-Leon P Pellicer A Diaz-Gimeno P
T-206 Endometrial Aging Evidence at Transcriptomic Level
Presented at the 67th Annual Meeting of the Society for Reproductive Investigation
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Neal SA Tao X Sun L Hanson BM Kim G Osman EK Tiegs AW Scott RT Franasiak JM P-219 HIGH CONCORDANCE BETWEEN VAGINAL AND CERVICAL MICROBIOME ASSESSMENTS WITH INCREASING MICROBIAL DIVERSITY NEGATIVELY IMPACTS PREGNANCY OUTCOMES FOLLOWING TRANSFER OF A SINGLE EUPLOID BLASTOCYST Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2019
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Nohales Corcoles M Del Gallego R Bori L Alegre L S. Shnizer Meseguer M P-246: High culture media oxidative profile as a biomarker of good quality embryos: a non-invasive tool to select the embryo to transfer. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ESHRE 2019
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Garrido N
O-223: Finding the best sperm
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Ferrero H Corachán A Quiñonero A Carbajo-García C Alamá P Tejera A Taboas E Muñoz E Pellicer A Domínguez F NGS of Oocytes from Endometriosis Patients Reveals a Differential Transcriptomic Pattern Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2019
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Pellegrini L Buigues A Sebastián-León P Diaz-Gimeno P Pellicer A Herraiz S
Transcriptomic Changes and Paracrine Factors Involved in Ovarian Rejuvenation Induced by Stem Cell_
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Salsano S Quiñonero A Yañez-Mo Gómez A Pérez S Dominguez F
Novel Non-Classic Progesterone P4 Receptor PGRMC1 Interactions and Functionality Reveal a Key Role
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Pirtea P Marin D Sun L Hong K Zhan Y Tao X Scott RT Gonadotrophin receptor polymorphisms (fshr n680s and lhcgr n312s) are not of clinical outcome and live birth in ivf cycles Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
ASRM 2018
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Bellver J Lathi RB Labarta E Vidal C Giles J Cabanillas S Marzal A Galliano D Marin C Ruiz-Alonso M Simón C Valbuena D
Obesity affects endometrial receptivity by inducing a displacement of the personalized woi that after correction by personalized embryo transfer normalize clinical results
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
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Insua M Escriba M Vendrell X Peinado V Viloria T
Segmental aneuploidy in blastocysts: when the chromosomes break
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Sakkas D Atkinson L Borini A Bosch E Bryce C Cattoli M Finet de Bantel A French B Gaitonde S Gerris J Granger S Grzegorczk-Martin V Howles C Somers S Alper M Can "patient-friendly" salivary hormone measurements replace serum monitoring of IVF Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
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Fatemi H Griesinger G Teal V Polyzos N Bosch E Johnson B Dos Santos S Garcia Velasco J Stoop D
FSH exposure between day 8 and day of Hcg administration is an independent predictor of serum progesterone rise
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Buigues A Herraiz S Marchante M Hsueh A J Pellicer A Fertility Rescue by Bone Marrow Derived Stem Cell Infusion Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2018
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Perez S Salsano S Quiñonero A Dominguez F
Phytoestrogens (Soy-Derived Metabolites) May Act Like Endometrial Disruptors Altering Decidualization of Human Endometrial Stromal Cells
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Cobo A Meseguer M Coello A Sanchez E Garcia Velasco J Remohí J Pellicer A Estimation of reproductive success according to age, number of oocytes and etiology in elective or oncological fertility preservation (FP) patients Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2017
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Coello A Sanchez E Campos P Vallejo B Meseguer M Cobo A
Oocyte dysmorphisms are not associated with post warming survival, fertilization and embryo development in own oocytes vitrification cycles
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Esbert M Marconetto A Reis Soares S Quera M Molina J Florensa M Ballesteros A Meseguer M
Does the blastocyst collapse respond to a biological need? The analysis of 1,952 embryos by time-lapse can give an answer
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Franasiak JM Hong KH Werner MD Juneau CR Morin SJ Neal SA Molinaro T Scott RT
Preimplantation genetic screening (PGS) in low responders shortens time to pregnancy: a randomized controlled trial
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Franasiak JM Scott RT Molina L Pellicer A
Serum vitamin D (OHD) levels are correlated with embryonic aneuploidy
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Goodman L Yoo N Pfeifer S Scott RT Shah D
Efficacy of an intensive "surgical boot camp" on laparoscopic suturing performance among reproductive endocrinology and infertility (REI) fellows
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Juneau CR Franasiak JM Morin SJ Werner MD Upham K Scott RT
Enmotion (embryo's natural motion): a paired randomized controlled trial demonstrating pregnancy rates are equivalent between static and dynamic culture systems
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Juneau CR Marin D Scott K Morin SJ Neal SA Juneau J Scott RT
Cares trial (celiac disease and reproductive effects): a gluten-free diet does not impact IVF outcomes
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Juneau CR Marin D Scott K Morin SJ Neal SA Juneau J Scott RT
Cares trial (celiac disease and reproductive effects): celiac disease is not more common in patients undergoing IVF and outcomes are not compromised in affected patients
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation