Receptividad endometrial
La interacción entre el embrión y la mucosa que recubre el interior del útero (el endometrio) es fundamental para lograr la implantación, el desarrollo de la placenta y, en última instancia, para conseguir un embarazo viable y un recién nacido. Esta interacción es un proceso complejo en el que todavía quedan cuestiones por comprender.
El momento exacto en el que se produce dicha interacción durante la ventana de implantación, que conllevará a que se produzca una sincronía entre embrión y endometrio, no había sido considerado hasta el momento como un factor crítico que influye en los resultados del tratamiento. Tanto las condiciones ambientales del laboratorio de FIV como el desarrollo embrionario, así como la gestión médica de la estimulación ovárica y la preparación endometrial, influyen en todo el proceso. El trabajo en este campo busca profundizar en el estudio fisiológico y patológico del proceso con el fin de obtener un bebé sano por transferencia embrionaria.
Investigadores trabajando en este área
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Públicaciones en este área
- Relevance of assessing the uterine microbiota in infertility.
Moreno I Simon C
Fertil Steril. 2018 Aug;110(3):337-343. doi: 10.1016/j.fertnstert.2018.04.041. Review.
- Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure.
Sebastian-Leon P Garrido N Remohí J Pellicer A Diaz-Gimeno P
Hum Reprod. 2018 Feb 14. doi: 10.1093/humrep/dey023. [Epub ahead of print]
- Human Endometrial Reconstitution From Somatic Stem Cells: The Importance of Niche-Like Cells.
Lopez-Perez N Gil-Sanchis C Ferrero H Faus A Diaz A Pellicer A Cervelló I Simón C
Reprod Sci. 2018 Jan 1:1933719118766251. doi: 10.1177/1933719118766251. [Epub ahead of print]
- Proteomic pattern of implantative human endometrial fluid in in vitro fertilization cycles.
Matorras R Quevedo S Corral B Prieto B Exposito A Mendoza R Rabanal A Diaz-Nuñez M Ferrando M Elortza F Ametzazurra A Nagore D
Arch Gynecol Obstet. 2018 Apr 10. doi: 10.1007/s00404-018-4753-1. [Epub ahead of print]
- Why natural killer cells are not enough: a further understanding of killer immunoglobulin-like receptor and human leukocyte antigen.
Alecsandru D Garcia Velasco J
Fertil Steril. 2017 Jun;107(6):1273-1278. doi: 10.1016/j.fertnstert.2017.04.018. Epub 2017 May 10. Review.
- Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers.
Altmae S Koel M Võsa U Adler P Suhorutšenko M Laisk-Podar T Kukushkina V Saare M Velthut-Meikas A Krjutškov K Aghajanova L Lalitkumar PG Gemzell-Danielsson K Giudice L Simón C Salumets A
Sci Rep. 2017 Aug 30;7(1):10077. doi: 10.1038/s41598-017-10098-3.
- De- and recellularization of the pig uterus: a bioengineering pilot study.
Campo H Baptista PM Lopez-Perez N Faus A Cervelló I Simón C
Biol Reprod. 2017 Jan 1;96(1):34-45. doi: 10.1095/biolreprod.116.143396.
- Impact of Endometrial Preparation Protocols for Frozen Embryo Transfer on Live Birth Rates.
Cerrillo M Herrero L Guillen A Mayoral M Garcia Velasco J
Rambam Maimonides Med J. 2017 Apr 28;8(2). doi: 10.5041/RMMJ.10297.
- Window of implantation transcriptomic stratification reveals different endometrial subsignatures associated with live birth and biochemical pregnancy.
Diaz-Gimeno P Ruiz-Alonso M Sebastian-Leon P Pellicer A Valbuena D Simón C
Fertil Steril. 2017 Aug 29. pii: S0015-0282(17)30502-2. doi: 10.1016/j.fertnstert.2017.07.007. [Epub ahead of print]
- Lipidomic profiling of endometrial fluid in women with ovarian endometriosis.
Dominguez F Ferrando M Diaz-Gimeno P Quintana F Fernandez G Castells I Simon C
Biol Reprod. 2017 Mar 18. doi: 10.1093/biolre/iox014. [Epub ahead of print]
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Presentaciones en esta área
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Bellver J Lathi RB Labarta E Vidal C Giles J Cabanillas S Marzal A Galliano D Marin C Ruiz-Alonso M Simón C Valbuena D Obesity affects endometrial receptivity by inducing a displacement of the personalized woi that after correction by personalized embryo transfer normalize clinical results Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ASRM 2018
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Alecsandru D Iglesias C Pacheco A Barrio A Garrido N Garcia Velasco J HLA-C haplotypes distribution among gametes donors in our population Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
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Devesa A Sebastian-Leon P Garcia-Garcia F Arnau V Pellicer A Diaz-Gimeno P
Functional genomic meta-analysis identifies similarities between endometrial-related subfertilities
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Salsano S Quiñonero A Pérez S González-Ravina C Simón C Dominguez F
Non-classical progesterone signaling may be sufficient to induce decidualization in Human Endometrial Stromal Cells (ESC)
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Azkargorta M Escobes I Lloro I Osinalde N Corral B Exposito A Prieto B Elortza F Matorras R
Differential proteomic analysis of endometrial fluid suggets increased inflammation and extracellular matrix remodeling in non-implantative IVF cycles
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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López-Pérez N Santamaría X Díaz-Gimeno P Sebastian-Leon P Faus A Remohí J Pellicer A Simón C Cervelló I Stem Cell-Secreted Paracrine Factors in Human Endometrial Regeneration Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
SRI 2018
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Perez S Salsano S Quiñonero A Dominguez F
Phytoestrogens (Soy-Derived Metabolites) May Act Like Endometrial Disruptors Altering Decidualization of Human Endometrial Stromal Cells
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
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Colombo S Franasiak JM Kaser DJ Molinaro T Bergh PA Significance of endometrial lining decrease after progesterone start in synthetic frozen embryo transfer (FET) cycles Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2017
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Alecsandru D Pacheco A Garrido N Barrio A Aparicio P Pellicer A Garcia Velasco J Live birth rate after oocyte donation is influenced by donor HLA-C: one step beyond conventional markers of success Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017
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Diaz-Gimeno P Sebastian-Leon P Remohí J Garrido N Pellicer A
New transcriptomic insight improves endometrial Recurrent Implantation Failure (RIF) diagnosis and distinguishes clearly between a displaced and a disrupted Window Of Implantation (WOI)
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Grasso A Navarro R Moreno I Herrero M Alama A Vilella F Simon C
Differential microRNA profile in the endometrial fluid (EF)in natural cycles, HRT, and controlled ovarian stimulation (COS) triggered with hCG (COS+hCG) or GnRHa (COS+GnRHa)
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Laisk T Suhorutshenko M Kukushkina V Velthut-Meikas A Magi R Peters M Altmäe S Krjut?kov K Martinez-Blanch JF Codoñer FM Vilella F Simon C Salumets A
Novel endometrial receptivity markers detected in largescale RNA-sequencing study combining samples from different populations
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Santamaría Costa X Cabanillas S Arbona C Cervelló I Raga F Ferro J Palmero J Remohí J Pellicer A Simon C
Stem cell treatment for endometrial pathologies
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Santamaría X Cervelló I Cabanillas S Arbona C Raga F Ferro J Palmero J Remohí J Pellicer A Simon C
Human Reproduction keynote lecture - Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Balaguer N Moreno I Herrero M González-Montfort M Simón C Vilella F Maternal MiR-30d deficiency is associated with defects in endometrial receptivity, embryonic implantation and fetal development Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
SRI 2017
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Bolumart D Moreno I Herrero M Cabanillas S Vilella F Simón C
Extracellular vesicles secreted by the human endometrium contain specific DNA sequences that are uptaken by Murine Embryos
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Díaz-Gimeno P Ruiz-Alonso M Sebastián-León P Singh V Pellicer A Valbuena D Simón C
Improvement of the endometrial receptivity signature reveals a possible maternal origin of biochemical pregnancies
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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López-Pérez N Gil-Sanchis C Faus A Diaz A Campo H Pellicer A Cervelló I Carlos Simón
Human endometrial reconstitution using W5C5, ICAM1 cells and side population cell lines in a xenograft model
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Salsano S Quiñonero A Pérez S Simón C Domínguez F
Non Classical Progesterone Receptor and SERPINE1mRNA (PGRMC1) Binding Protein (SERBP1) Interaction Influences the Human Decidualization Process
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Sebastian-León P Conesa A Arnau V Remohí J Pellicer A Simón C Diaz-Gimeno P
Network biology of menstrual cycle to understand the key drivers of endometrial receptivity
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Vilella F Behr B Reddy V Wang W Navarro R Jiménez J Quake S C Simón
Maternal endometrial hsa-miR-30d is taken up by the human blastocyst and induces transcriptional modifications
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation