Manuel Fernández-Sánchez, M.D., Ph.D.

Director of IVI Sevilla

IVI Sevilla

Biografía

Manuel Fernández-Sánchez is the director of IVI Sevilla, Associate Professor of Assisted Reproductive Technology and Gene Therapy in Molecular Biology and Biochemical Engineering in Department, Pablo Olavide University, Sevilla, and Associate Professor of Biomedicine and Gynecology in Faculty of Medicine, University of Sevilla. Dr. Fernandez-Sanchez, trained at CHI Andre Gregoire Hospital of Paris (France), and The Queen’s Medical Research Institute in Edinburgh (the United Kingdom). He also obtained a Degree of Statistics and Research Methodology at the University Autónoma of Barcelona, he completed a Master of Human Reproduction at University Rey Juan Carlos of Madrid and an Executive Master in Management and Administration of Health Institutions in Esade Business School, Ramon Llul University, Madrid.

He holds a Ph.D. in medicine from the University of Valencia. He has published research articles in leading international reproductive journals and received four Seville Medical Society Awards and two Royal Medicine Academy of Seville Awards. He was the National Coordinator of Embryo Health Task Force of Spanish Fertility Society for 4 years. He is an elected Member of the Royal Academy of Medicine Seville.

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Formación

MD	University of Sevilla (1996)
Residency	University of Seville (2002)
Fellowship	CHI Andre Gregoire Hospital of Paris (2002)
M.Sc. in Statistics and Research Methodology	Autonomous University of Barcelona (2008)
Fellowship	The Queen’s Medical Research Institute in Edinburgh (2009)
MSc in Human Reproduction	Rey Juan Carlos University of Madrid (2009)
Ph.D.	University of Valencia (2012)
M.Sc. in Management and Administration of Health Institutions	Ramón Llull University (2015)

Honores y reconocimientos

Illustrious doctor by the Royal Medicine Academy of Seville	2015
1st Award of the Royal Medicine Academy of Seville	2008
1st Award of the Royal Medicine Academy of Seville	2006
3rd Merck-Serono Award, Salud 2000 Foundation. Clinical investigation Area	2006
1st Scientific Award of the Seville Medical Society	2006

Publicaciones

Deregulation of miR-324/Kiss1/kisspeptin in early ectopic pregnancy: Mechanistic findings with clinical and diagnostic implications.
Romero-Ruiz A Avendaño MS Dominguez F Lozoya T Molina-Abril H Sangiao-Alvarellos S Gurrea M Lara-Chica M Fernandez-Sanchez M Torres E Perdices-Lopez C Abbara A Steffani L Calzado MA Dhillo WS Pellicer A Tena-Sempere M
Am J Obstet Gynecol. 2019 Jan 29. pii: S0002-9378(19)30282-0. doi: 10.1016/j.ajog.2019.01.228. [Epub ahead of print

Individualization of the starting dose of follitropin delta reduces the overall OHSS risk and/or the need for additional preventive interventions: cumulative data over three stimulation cycles.
Fernández-Sánchez M Visnova H Yuzpe A Klein BM Mannaerts B Arce JC; ESTHER-1 and ESTHER-2 Study Group
Reprod Biomed Online. 2018 Dec 23. pii: S1472-6483(18)30661-8. doi: 10.1016/j.rbmo.2018.12.032. [Epub ahead of print]

Individualization of the starting dose of follitropin delta reduces the overall OHSS risk and/or the need of additional preventive interventions: Cumulative data over three stimulation cycles
Fernández-Sánchez M Visnova H Yuzpe A Klein BJ ESTHER-1 and ESTHER-2 Study Group
Reprod Biomed Online, NA:NA-NA, 2018.

Altered expression of the kisspeptin/KISS1R and neurokinin B/NK3R systems in mural granulosa and cumulus cells of patients with polycystic ovarian syndrome.
Blasco V Pinto FM Fernández-Atucha A Tena-Sempere M Fernández-Sánchez M Candenas L
J Assist Reprod Genet, NA:NA-NA, 2018.

Different Endometrial Receptivity in Each Hemiuterus of a Woman with Uterus Didelphys and Previous Failed Embryo Transfers.
Carranza F González-Ravina A Blasco V Fernández-Sánchez M
J Hum Reprod Sci, 11(3):297-299, 2018.

Effect of dietary supplementation with a highly pure and concentrated docosahexaenoic acid (DHA) supplement on human sperm function.
González-Ravina C Aguirre-Lipperheide M Pinto F Martín-Lozano D Fernández-Sánchez M Blasco V Santamaría-López E Candenas L
Reprod Biol, 18(3):282-288, 2018.

Veratridine-sensitive Na+ channels regulate human sperm fertilization capacity.
Candenas L Pinto FM Cejudo Román A González-Ravina C Fernández-Sánchez M Pérez-Hernández Irazusta J Subirán N
Life Sci, 196:48-55, 2018.

Ferroportin mRNA is down-regulated in granulosa and cervical cells from infertile women.
Moreno-Navarrete JM López-Navarro E Candenas L Pinto F Ortega FJ Sabater-Masdeu M Fernández-Sánchez M Blasco V Romero-Ruiz A Fontán M Ricart W Tena-Sempere M Fernández-Real JM
Fertil Steril, 107 (1): 236-242, 2017.

Leptin action in normal and pathological pregnancies.
Pérez-Pérez A Toro A Vilariño-García T Maymo J Guadix P Dueñas JL Fernández-Sánchez M Varone C Sánchez-Margalet V
J Cell Mol Med. 2017 Nov 21. doi: 10.1111/jcmm.13369. [Epub ahead of print] Review.

Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects
Pérez-Pérez A Guadix P Maymó J Dueñas J Varone C Fernández-Sánchez M Sánchez-Margalet V
Horm Metab Res, 48 (1): 62-69, 2016.

Ferroportin mRNA is down-regulated in granulosa and cervical cells from infertile women.
Moreno-Navarrete JM, López-Navarro E, Candenas L, Pinto F, Ortega FJ, Sabater-Masdeu M, Fernández-Sánchez M, Blasco V, Romero-Ruiz A, Fontán M, Ricart W, Tena-Sempere M, Fernández-Real JM.
Fertil Steril, 107 (1): 236-242, 2017.

Individualized versus conventional ovarian stimulation for in vitro fertilization: a multicenter, randomized, controlled, assessor-blinded, phase 3 noninferiority trial.
Nyboe Andersen A, Nelson SM, Fauser BC, García-Velasco JA, Klein BM, Arce JC; ESTHER-1 study group.
Fertil Steril, 107 (2): 387-396.e4, 2017.

Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects.
Pérez-Pérez A, Guadix P, Maymó J, Dueñas JL, Varone C, Fernández-Sánchez M, Sánchez-Margalet V.
Horm Metab Res, 48 (1): 62-69, 2016.

Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells.
García-Ortega J, Pinto FM, Prados N, Bello AR, Almeida TA, Fernández-Sánchez M, Candenas L.
Biol Reprod, 94 (6): 124, 2016.

Increased Expression of Aquaporin 9 in Trophoblast From Gestational Diabetic Patients.
Vilariño-García T, Pérez-Pérez A, Dietrich V, Fernández-Sánchez M, Guadix P, Dueñas JL, Varone CL, Damiano AE, Sánchez-Margalet V.
Horm Metab Res, 48 (8): 535-539, 2016.

Elective single versus double embryo transfer: live birth outcome and patient acceptance in a prospective randomised trial.
Prados N, Quiroga R, Caligara C, Ruiz M, Blasco V, Pellicer A, Fernández-Sánchez M.
Reprod Fertil Dev, 27 (5): 794-800, 2015.

Monozygotic twinning after assisted reproductive technologies: a case report of asymmetric development and incidence during 19 years in an international group of in vitro fertilization clinics.
Tocino A, Blasco V, Prados N, Vargas MJ, Requena A, Pellicer A, Fernández-Sánchez M.
Fertil Steril, 103 (5): 1185-1189, 2015.

Follicular and endocrine dose responses according to anti-Mullerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049).
Bosch E, Nyboe Andersen A, Barri P, García-Velasco JA, de Sutter P, Fernández-Sánchez M, Visnova H, Klein BM, Mannaerts B, Arce JC.
Clin Endocrinol, 83 (6): 902-912, 2015.

Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells.
García-Ortega J Pinto FM Bello AR Almeida TA Fernández-Sánchez M Candenas L
Biol Reprod, 94 (6): 124, 2016.

Increased Expression of Aquaporin 9 in Trophoblast From Gestational Diabetic Patients.
Vilariño-García T Pérez-Pérez A Dietrich V Fernández-Sánchez M Guadix P Dueñas JL Varone CL Damiano AE Sánchez-Margalet V
Horm Metab Res, 48 (8): 535-539, 2016

How to Perform the Best Intrauterine Insemination? A Review. Andrology-Open Access.
Carranza F Santamaría E González-Ravina C Blasco V Caligara C Fernández-Sánchez M
4 - 2, pp. 1 - 7. OMICS group, 2015.

Elective single versus double embryo transfer: live birth outcome and patient acceptance in a prospective randomised trial.
Quiroga R Caligara C Ruiz M Blasco V Pellicer A Fernández-Sánchez M
Reprod Fertil Dev, 27 (5): 794-800, 2015

Monozygotic twinning after assisted reproductive technologies: a case report of asymmetric development and incidence during 19 years in an international group of in vitro fertilization clinics.
Tocino A Blasco V Vargas MJ Requena A Pellicer A Fernández-Sánchez M
Fertil Steril, 103 (5): 1185-1189, 2015

Follicular and endocrine dose responses according to anti-Mullerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049).
Bosch E Nyboe Andersen A García-Velasco JA Sutter P Fernández-Sánchez M Visnova H Klein BM Mannaerts B Arce JC
Clin Endocrinol, 83 (6): 902-912, 2015

Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049).
Bosch E Nyboe Andersen A Barri P García-Velasco JA de Sutter P Fernández-Sánchez M Visnova H Klein BM Mannaerts B Arce JC
Clin Endocrinol (Oxf). 83:902-12, 2015.

Influence of follicle rupture and uterine contractions on intrauterine insemination outcome: a new predictive model.
Blasco V Carranza F González-Ravina C Pellicer A Fernández-Sánchez M
Fertil Steril, 102(4):1034-40, 2014.

Expression of neurokinin B/NK3 receptor and kisspeptin/KISS1 receptor in human granulosa cells.
García-Ortega J Pinto FM Fernández-Sánchez M Cejudo Román A Almeida TA Hernández M Romero M Tena-Sempere M Candenas L
Hum Reprod, 29:2736-46, 2014.

Ovarian response to recombinant human follicle-stimulating hormone: a randomized, antimüllerian hormone-stratified, dose-response trial in women undergoing in vitro fertilization/intracytoplasmic sper
Arce JC Andersen AN Fernández-Sánchez M Visnova H Bosch E García-Velasco JA Barri P de Sutter P Klein BM Fauser BC
Fertil Steril. 102:1633-40, 2014.

The voltage-gated sodium channel Nav1.8 is expressed in human sperm.
Cejudo Román A Pinto FM Subirán N Ravina CG Fernández-Sánchez M Pérez-Hernández N Pérez R Pacheco A Irazusta J Candenas L
PLoS One, 8:e76084, 2013.

Characterization of the kisspeptin system in human spermatozoa
Pinto FM Cejudo Román A González-Ravina C Fernández-Sánchez M Martín-Lozano D Illanes M Tena-Sempere M Candenas L
Int J Androl 35:63-73, 2012

The non-ergot derived dopamine agonist quinagolide in prevention of early ovarian hyperstimulation syndrome in IVF patients: a randomized, double-blind, placebo-controlled trial.
Busso C Fernández-Sánchez M García-Velasco JA Landeras J Ballesteros A Muñoz E González S Simón C Arce JC Pellicer A
Hum Reprod. 25:995-1004, 2010.

Autocrine regulation of human sperm motility by tachykinins
Pinto FM Ravina CG Subiran N Cejudo Román A Fernández-Sánchez M Irazusta J Garrido N Candenas L
Reprod Biol Endocrinol, 8:104, 2010.

Clinical Factors affecting endometrial receptiveness in oocyte donation cycles.
Soares SR García-Velasco JA Fernández-Sánchez M Bosch E Remohí J Pellicer A Simón C
Fertil Steril, 89(3):491-501, 2008

Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system.
Budak E Fernández-Sánchez M Bellver J Cerveró A Simón C Pellicer A
Fertil Steril, 85:1563-81, 2006.

Expression of neurokinin B/NK3 receptor and kisspeptin/KISS1 receptor in human granulosa cells.
García-Ortega J, Pinto FM, Fernández-Sánchez M, Prados N, Cejudo-Román A, Almeida TA, Hernández M, Romero M, Tena-Sempere M, Candenas L. Human Reprod, 29 (12): 2736-2746, 2014.

Influence of follicle rupture and uterine contractions on intrauterine insemination outcome: a new predictive model.
Blasco V, Prados N, Carranza F, González-Ravina C, Pellicer A, Fernández-Sánchez M.
Fertil Steril, 102 (4): 1034-1040, 2014.

Ovarian response to recombinant human follicle-stimulating hormone: a randomized, antimullerian hormone-stratified, dose-response trial in women undergoing in vitro fertilization/intracytoplasmic sperm injection.
Arce JC, Andersen AN, Fernández-Sánchez M, Visnova H, Bosch E, García- Velasco JA, Barri P, de Sutter P, Klein BM, Fauser BC.
Fertil Steril, 102 (6): 1633-U456, 2014.

Impact of assisted reproduction treatments on Spanish newborns: report of 14,119 pregnancies.
Ricciarelli E, Bruna I, Verdú V, Torrelló MJ, Herrer R, Gris JM, Arroyo G, Pérez-Millán F, Del Río F, Fernández-Sánchez M, Cabello Y, Ardoy M, Fernández-Shaw S.
J Assist Reprod Genet, 30 (7): 897-905, 2013.

The Voltage-Gated Sodium Channel Nav1.8 Is Expressed in Human Sperm.
Cejudo-Roman A, Pinto FM, Subirán N, Ravina CG, Fernández-Sánchez M, Pérez-Hernández N, Pérez R, Pacheco A, Irazusta J, Candenas L.
PloS One, 8 (9): e76084, 2013.

The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.
Ruiz-Alonso M, Blesa D, Díaz-Gimeno P, Gómez E, Fernández-Sánchez M, Carranza F, Carrera J, Vilella F, Pellicer A, Simón C.
Fertil Steril, 100 (3): 818-824, 2013.

Characterization of the kisspeptin system in human spermatozoa.
Pinto FM, Cejudo-Román A, Ravina CG, Fernández-Sánchez M, Martín-Lozano D, Illanes M, Tena-Sempere M, Candenas ML.
Int J Androl, 35 (1): 63-73, 2012.

A comparison of live birth rates and cumulative ongoing pregnancy rates between Europe and North America after ovarian stimulation with corifollitropin alfa or recombinant follicle-stimulating hormone.
Boostanfar R, Mannaerts B, Pang S, Fernandez-Sanchez M, Witjes H, Devroey P; Engage Investigators.
Fertil Steril, 97(6): 1351-1358, 2012.

The non-ergot derived dopamine agonist quinagolide in prevention of early ovarian hyperstimulation syndrome in IVF patients: a randomized, double-blind, placebo-controlled trial(dagger).
Busso C, Fernández-Sánchez M, García-Velasco JA, Landeras J, Ballesteros A, Muñoz E, González S, Simón C, Arce JC, Pellicer A.
Human Reprod, 25 (4): 995-1004, 2010.

Could the addition of hp-hMG and GnRH antagonists modulate the response in IVFICSI cycles?
Requena A, Landeras JL, Martínez-Navarro L, Calatayud C, Sánchez F, Maldonado V, Muñoz M, Fernández M, González A, López S, López R, Pacheco A, Calderón G, Martínez V.
Hum Fertil, 13 (1): 4151, 2010.

Autocrine regulation of human sperm motility by tachykinins.
Pinto FM, Ravina CG, Subiran N, Cejudo-Román A, Fernández-Sánchez M, Irazusta J, Garrido N, Candenas L.
Reprod Biol Endocrinol, 8 (104): 10.1186/1477-7827-8-104, 2010.

An in vivo culture system for human embryos using an encapsulation technology: a pilot study.
Blockeel C, Mock P, Verheyen G, Bouche N, Le Goff P, Heyman Y, Wrenzycki C, Höffmann K, Niemann H, Haentjens P, de Los Santos MJ, Fernandez-Sanchez M, Velasco M, Aebischer P, Devroey P, Simón C.
Human Reprod, 24 (4): 790-796, 2009.

Molecular and functional characterization of voltage-gated sodium channels in human sperm.
Pinto FM, Ravina CG, Fernández-Sánchez M, Gallardo-Castro M, Cejudo-Román A, Candenas L.
Reprod Biol Endocrinol, 7 (71): 10.1186/1477-7827-7-71, 2009.

Clinical factors affecting endometrial receptiveness in oocyte donation cycles.
Soares SR, Velasco JA, Fernandez M, Bosch E, Remohí J, Pellicer A, Simón C.
Fertil Steril, 89 (3): 491-501, 2008.

A role for tachykinins in the regulation of human sperm motility.
Ravina CG, Seda M, Pinto FM, Orea A, Fernández-Sánchez M, Pintado CO, Candenas ML.
Human Reprod, 22 (6): 1617-1625, 2007.

Dopamine agonist cabergoline reduces hemoconcentration and ascites in hyperstimulated women undergoing assisted reproduction.
Alvarez C, Martí-Bonmatí L, Novella-Maestre E, Sanz R, Gómez R, Fernández-Sánchez M, Simón C, Pellicer A.
J Clin Endocrinol Metab, 92 (8): 2931-2937, 2007.

Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system.
Budak E, Fernández Sánchez M, Bellver J, Cerveró A, Simón C, Pellicer A. Fertil Steril, 85 (6): 1563-1581, 2006.

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Presentations

Simon C Gómez C Cabanillas S Vladimirov IK Castillón G Giles J Boynukalin FK Findikli N Ortega I Vidal C Izquierdo A Portela S Frantz N Taguchi S Labarta E Colucci F Mackens S Santamaría X Muñoz E Barrera SG Fernandez-Sanchez M Ferrando M Pellicer A Mol BW Valbuena D O-134 IN VITRO FERTILIZATION WITH PERSONALIZED BLASTOCYST TRANSFER VERSUS FROZEN OR FRESH BLASTOCYST TRANSFER: A MULTICENTER, RANDOMIZED CLINICAL TRIAL. Presented at 75th American Society of Reproductive Medicine Scientific Congress, Philadelphia, PA. USA, 14-16 October 2019

Fernandez-Sanchez M Visnova H Yuzpe A Klein BM Mannaerts B Arce JC Individualization of the starting dose of gonadotropin reduces the overall ohss risk and the need of preventive cumulative data over three. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver, CO, USA, October 6-10, 2018

González-Ravina C Cruz M Rubio C Fernández-Sánchez M Oquiñena E Ferrando R Requena A Polymorphic chromosome variants, human inversions, and their functional consequences in male infertility. Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology, Geneva,Switerland, July 2-5 ,2017

Rubio Lluesa C Cruz M González-Ravina C Fernández-Sánchez M Oquiñena E Requena A Polymorphism on chromosome 21 does not affect ovarian reserve but clinical outcomes after in vitro fertilization treatments. Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology, Geneva,Switerland, July 2-5 ,2017

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