Manuel Fernández-Sánchez, M.D., Ph.D.


Manuel Fernández-Sánchez is the director of IVI Sevilla, Associate Professor of Assisted Reproductive Technology and Gene Therapy in Molecular Biology and Biochemical Engineering in Department, Pablo Olavide University, Sevilla, and Associate Professor of Biomedicine and Gynecology in Faculty of Medicine, University of Sevilla. Dr. Fernandez-Sanchez, trained at CHI Andre Gregoire Hospital of Paris (France), and The Queen’s Medical Research Institute in Edinburgh (the United Kingdom). He also obtained a Degree of Statistics and Research Methodology at the University Autónoma of Barcelona, he completed a Master of Human Reproduction at University Rey Juan Carlos of Madrid and an Executive Master in Management and Administration of Health Institutions in Esade Business School, Ramon Llul University, Madrid.

He holds a Ph.D. in medicine from the University of Valencia. He has published research articles in leading international reproductive journals and received four Seville Medical Society Awards and two Royal Medicine Academy of Seville Awards. He was the National Coordinator of Embryo Health Task Force of Spanish Fertility Society for 4 years. He is an elected Member of the Royal Academy of Medicine Seville.

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MD University of Sevilla (1996)
Residency University of Seville (2002)
Fellowship CHI Andre Gregoire Hospital of Paris (2002)
M.Sc. in Statistics and Research Methodology Autonomous University of Barcelona (2008)
Fellowship The Queen’s Medical Research Institute in Edinburgh (2009)
MSc in Human Reproduction Rey Juan Carlos University of Madrid (2009)
Ph.D. University of Valencia (2012)
M.Sc. in Management and Administration of Health Institutions Ramón Llull University (2015)

Honores y reconocimientos

Illustrious doctor by the Royal Medicine Academy of Seville 2015
1st Award of the Royal Medicine Academy of Seville 2008
1st Award of the Royal Medicine Academy of Seville 2006
3rd Merck-Serono Award, Salud 2000 Foundation. Clinical investigation Area 2006
1st Scientific Award of the Seville Medical Society 2006


  • Ferroportin mRNA is down-regulated in granulosa and cervical cells from infertile women.
    Moreno-Navarrete JM, López-Navarro E, Candenas L, Pinto F, Ortega FJ, Sabater-Masdeu M, Fernández-Sánchez M, Blasco V, Romero-Ruiz A, Fontán M, Ricart W, Tena-Sempere M, Fernández-Real JM.
    Fertil Steril, 107 (1): 236-242, 2017.

  • Individualized versus conventional ovarian stimulation for in vitro fertilization: a multicenter, randomized, controlled, assessor-blinded, phase 3 noninferiority trial.
    Nyboe Andersen A, Nelson SM, Fauser BC, García-Velasco JA, Klein BM, Arce JC; ESTHER-1 study group.
    Fertil Steril, 107 (2): 387-396.e4, 2017.

  • Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects.
    Pérez-Pérez A, Guadix P, Maymó J, Dueñas JL, Varone C, Fernández-Sánchez M, Sánchez-Margalet V.
    Horm Metab Res, 48 (1): 62-69, 2016.

  • Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells.
    García-Ortega J, Pinto FM, Prados N, Bello AR, Almeida TA, Fernández-Sánchez M, Candenas L.
    Biol Reprod, 94 (6): 124, 2016.

  • Increased Expression of Aquaporin 9 in Trophoblast From Gestational Diabetic Patients.
    Vilariño-García T, Pérez-Pérez A, Dietrich V, Fernández-Sánchez M, Guadix P, Dueñas JL, Varone CL, Damiano AE, Sánchez-Margalet V.
    Horm Metab Res, 48 (8): 535-539, 2016.

  • Elective single versus double embryo transfer: live birth outcome and patient acceptance in a prospective randomised trial.
    Prados N, Quiroga R, Caligara C, Ruiz M, Blasco V, Pellicer A, Fernández-Sánchez M.
    Reprod Fertil Dev, 27 (5): 794-800, 2015.

  • Monozygotic twinning after assisted reproductive technologies: a case report of asymmetric development and incidence during 19 years in an international group of in vitro fertilization clinics.
    Tocino A, Blasco V, Prados N, Vargas MJ, Requena A, Pellicer A, Fernández-Sánchez M.
    Fertil Steril, 103 (5): 1185-1189, 2015.

  • Follicular and endocrine dose responses according to anti-Mullerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049).
    Bosch E, Nyboe Andersen A, Barri P, García-Velasco JA, de Sutter P, Fernández-Sánchez M, Visnova H, Klein BM, Mannaerts B, Arce JC.
    Clin Endocrinol, 83 (6): 902-912, 2015.


  • Expression of neurokinin B/NK3 receptor and kisspeptin/KISS1 receptor in human granulosa cells.
    García-Ortega J, Pinto FM, Fernández-Sánchez M, Prados N, Cejudo-Román A, Almeida TA, Hernández M, Romero M, Tena-Sempere M, Candenas L. Human Reprod, 29 (12): 2736-2746, 2014.

  • Influence of follicle rupture and uterine contractions on intrauterine insemination outcome: a new predictive model.
    Blasco V, Prados N, Carranza F, González-Ravina C, Pellicer A, Fernández-Sánchez M.
    Fertil Steril, 102 (4): 1034-1040, 2014.

  • Ovarian response to recombinant human follicle-stimulating hormone: a randomized, antimullerian hormone-stratified, dose-response trial in women undergoing in vitro fertilization/intracytoplasmic sperm injection.
    Arce JC, Andersen AN, Fernández-Sánchez M, Visnova H, Bosch E, García- Velasco JA, Barri P, de Sutter P, Klein BM, Fauser BC.
    Fertil Steril, 102 (6): 1633-U456, 2014.

  • Impact of assisted reproduction treatments on Spanish newborns: report of 14,119 pregnancies.
    Ricciarelli E, Bruna I, Verdú V, Torrelló MJ, Herrer R, Gris JM, Arroyo G, Pérez-Millán F, Del Río F, Fernández-Sánchez M, Cabello Y, Ardoy M, Fernández-Shaw S.
    J Assist Reprod Genet, 30 (7): 897-905, 2013.

  • The Voltage-Gated Sodium Channel Nav1.8 Is Expressed in Human Sperm.
    Cejudo-Roman A, Pinto FM, Subirán N, Ravina CG, Fernández-Sánchez M, Pérez-Hernández N, Pérez R, Pacheco A, Irazusta J, Candenas L.
    PloS One, 8 (9): e76084, 2013.

  • The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.
    Ruiz-Alonso M, Blesa D, Díaz-Gimeno P, Gómez E, Fernández-Sánchez M, Carranza F, Carrera J, Vilella F, Pellicer A, Simón C.
    Fertil Steril, 100 (3): 818-824, 2013.

  • Characterization of the kisspeptin system in human spermatozoa.
    Pinto FM, Cejudo-Román A, Ravina CG, Fernández-Sánchez M, Martín-Lozano D, Illanes M, Tena-Sempere M, Candenas ML.
    Int J Androl, 35 (1): 63-73, 2012.

  • A comparison of live birth rates and cumulative ongoing pregnancy rates between Europe and North America after ovarian stimulation with corifollitropin alfa or recombinant follicle-stimulating hormone.
    Boostanfar R, Mannaerts B, Pang S, Fernandez-Sanchez M, Witjes H, Devroey P; Engage Investigators.
    Fertil Steril, 97(6): 1351-1358, 2012.

  • The non-ergot derived dopamine agonist quinagolide in prevention of early ovarian hyperstimulation syndrome in IVF patients: a randomized, double-blind, placebo-controlled trial(dagger).
    Busso C, Fernández-Sánchez M, García-Velasco JA, Landeras J, Ballesteros A, Muñoz E, González S, Simón C, Arce JC, Pellicer A.
    Human Reprod, 25 (4): 995-1004, 2010.

  • Could the addition of hp-hMG and GnRH antagonists modulate the response in IVFICSI cycles?
    Requena A, Landeras JL, Martínez-Navarro L, Calatayud C, Sánchez F, Maldonado V, Muñoz M, Fernández M, González A, López S, López R, Pacheco A, Calderón G, Martínez V.
    Hum Fertil, 13 (1): 4151, 2010.

  • Autocrine regulation of human sperm motility by tachykinins.
    Pinto FM, Ravina CG, Subiran N, Cejudo-Román A, Fernández-Sánchez M, Irazusta J, Garrido N, Candenas L.
    Reprod Biol Endocrinol, 8 (104): 10.1186/1477-7827-8-104, 2010.

  • An in vivo culture system for human embryos using an encapsulation technology: a pilot study.
    Blockeel C, Mock P, Verheyen G, Bouche N, Le Goff P, Heyman Y, Wrenzycki C, Höffmann K, Niemann H, Haentjens P, de Los Santos MJ, Fernandez-Sanchez M, Velasco M, Aebischer P, Devroey P, Simón C.
    Human Reprod, 24 (4): 790-796, 2009.

  • Molecular and functional characterization of voltage-gated sodium channels in human sperm.
    Pinto FM, Ravina CG, Fernández-Sánchez M, Gallardo-Castro M, Cejudo-Román A, Candenas L.
    Reprod Biol Endocrinol, 7 (71): 10.1186/1477-7827-7-71, 2009.

  • Clinical factors affecting endometrial receptiveness in oocyte donation cycles.
    Soares SR, Velasco JA, Fernandez M, Bosch E, Remohí J, Pellicer A, Simón C.
    Fertil Steril, 89 (3): 491-501, 2008.

  • A role for tachykinins in the regulation of human sperm motility.
    Ravina CG, Seda M, Pinto FM, Orea A, Fernández-Sánchez M, Pintado CO, Candenas ML.
    Human Reprod, 22 (6): 1617-1625, 2007.

  • Dopamine agonist cabergoline reduces hemoconcentration and ascites in hyperstimulated women undergoing assisted reproduction.
    Alvarez C, Martí-Bonmatí L, Novella-Maestre E, Sanz R, Gómez R, Fernández-Sánchez M, Simón C, Pellicer A.
    J Clin Endocrinol Metab, 92 (8): 2931-2937, 2007.

  • Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system.
    Budak E, Fernández Sánchez M, Bellver J, Cerveró A, Simón C, Pellicer A. Fertil Steril, 85 (6): 1563-1581, 2006.

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