Manuel Fernández-Sánchez is the director of IVI Sevilla, Associate Professor of Assisted Reproductive Technology and Gene Therapy in Molecular Biology and Biochemical Engineering in Department, Pablo Olavide University, Sevilla, and Associate Professor of Biomedicine and Gynecology in Faculty of Medicine, University of Sevilla. Dr. Fernandez-Sanchez, trained at CHI Andre Gregoire Hospital of Paris (France), and The Queen’s Medical Research Institute in Edinburgh (the United Kingdom). He also obtained a Degree of Statistics and Research Methodology at the University Autónoma of Barcelona, he completed a Master of Human Reproduction at University Rey Juan Carlos of Madrid and an Executive Master in Management and Administration of Health Institutions in Esade Business School, Ramon Llul University, Madrid.
He holds a Ph.D. in medicine from the University of Valencia. He has published research articles in leading international reproductive journals and received four Seville Medical Society Awards and two Royal Medicine Academy of Seville Awards. He was the National Coordinator of Embryo Health Task Force of Spanish Fertility Society for 4 years. He is an elected Member of the Royal Academy of Medicine Seville.
Education and Training
|MD||University of Sevilla (1996)|
|Residency||University of Seville (2002)|
|Fellowship||CHI Andre Gregoire Hospital of Paris (2002)|
|M.Sc. in Statistics and Research Methodology||Autonomous University of Barcelona (2008)|
|Fellowship||The Queen’s Medical Research Institute in Edinburgh (2009)|
|MSc in Human Reproduction||Rey Juan Carlos University of Madrid (2009)|
|Ph.D.||University of Valencia (2012)|
|M.Sc. in Management and Administration of Health Institutions||Ramón Llull University (2015)|
Honors and recognition
|Illustrious doctor by the Royal Medicine Academy of Seville||2015|
|1st Award of the Royal Medicine Academy of Seville||2008|
|1st Award of the Royal Medicine Academy of Seville||2006|
|3rd Merck-Serono Award, Salud 2000 Foundation. Clinical investigation Area||2006|
|1st Scientific Award of the Seville Medical Society||2006|
Tachykinins and Kisspeptins in the Regulation of Human Male Fertility.
Blasco V Pinto FM González-Ravina C Santamaría-López E Candenas L Fernández-Sánchez M
J Clin Med. 2019 Dec 31;9(1). pii: E113. doi: 10.3390/jcm9010113. Review.
Deregulation of miR-324/Kiss1/kisspeptin in early ectopic pregnancy: Mechanistic findings with clinical and diagnostic implications.
Romero-Ruiz A Avendaño MS Dominguez F Lozoya T Molina-Abril H Sangiao-Alvarellos S Gurrea M Lara-Chica M Fernandez-Sanchez M Torres E Perdices-Lopez C Abbara A Steffani L Calzado MA Dhillo WS Pellicer A Tena-Sempere M
Am J Obstet Gynecol. 2019 Jan 29. pii: S0002-9378(19)30282-0. doi: 10.1016/j.ajog.2019.01.228. [Epub ahead of print
Individualization of the starting dose of follitropin delta reduces the overall OHSS risk and/or the need for additional preventive interventions: cumulative data over three stimulation cycles.
Fernández-Sánchez M Visnova H Yuzpe A Klein BM Mannaerts B Arce JC; ESTHER-1 and ESTHER-2 Study Group
Reprod Biomed Online. 2018 Dec 23. pii: S1472-6483(18)30661-8. doi: 10.1016/j.rbmo.2018.12.032. [Epub ahead of print]
Individualization of the starting dose of follitropin delta reduces the overall OHSS risk and/or the need of additional preventive interventions: Cumulative data over three stimulation cycles
Fernández-Sánchez M Visnova H Yuzpe A Klein BJ ESTHER-1 and ESTHER-2 Study Group
Reprod Biomed Online, NA:NA-NA, 2018.
Altered expression of the kisspeptin/KISS1R and neurokinin B/NK3R systems in mural granulosa and cumulus cells of patients with polycystic ovarian syndrome.
Blasco V Pinto FM Fernández-Atucha A Tena-Sempere M Fernández-Sánchez M Candenas L
J Assist Reprod Genet, NA:NA-NA, 2018.
Different Endometrial Receptivity in Each Hemiuterus of a Woman with Uterus Didelphys and Previous Failed Embryo Transfers.
Carranza F González-Ravina A Blasco V Fernández-Sánchez M
J Hum Reprod Sci, 11(3):297-299, 2018.
Effect of dietary supplementation with a highly pure and concentrated docosahexaenoic acid (DHA) supplement on human sperm function.
González-Ravina C Aguirre-Lipperheide M Pinto F Martín-Lozano D Fernández-Sánchez M Blasco V Santamaría-López E Candenas L
Reprod Biol, 18(3):282-288, 2018.
Veratridine-sensitive Na+ channels regulate human sperm fertilization capacity.
Candenas L Pinto FM Cejudo Román A González-Ravina C Fernández-Sánchez M Pérez-Hernández Irazusta J Subirán N
Life Sci, 196:48-55, 2018.
Ferroportin mRNA is down-regulated in granulosa and cervical cells from infertile women.
Moreno-Navarrete JM López-Navarro E Candenas L Pinto F Ortega FJ Sabater-Masdeu M Fernández-Sánchez M Blasco V Romero-Ruiz A Fontán M Ricart W Tena-Sempere M Fernández-Real JM
Fertil Steril, 107 (1): 236-242, 2017.
Leptin action in normal and pathological pregnancies.
Pérez-Pérez A Toro A Vilariño-García T Maymo J Guadix P Dueñas JL Fernández-Sánchez M Varone C Sánchez-Margalet V
J Cell Mol Med. 2017 Nov 21. doi: 10.1111/jcmm.13369. [Epub ahead of print] Review.
Insulin and Leptin Signaling in Placenta from Gestational Diabetic Subjects
Pérez-Pérez A Guadix P Maymó J Dueñas J Varone C Fernández-Sánchez M Sánchez-Margalet V
Horm Metab Res, 48 (1): 62-69, 2016.
Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells.
García-Ortega J Pinto FM Bello AR Almeida TA Fernández-Sánchez M Candenas L
Biol Reprod, 94 (6): 124, 2016.
Increased Expression of Aquaporin 9 in Trophoblast From Gestational Diabetic Patients.
Vilariño-García T Pérez-Pérez A Dietrich V Fernández-Sánchez M Guadix P Dueñas JL Varone CL Damiano AE Sánchez-Margalet V
Horm Metab Res, 48 (8): 535-539, 2016
How to Perform the Best Intrauterine Insemination? A Review. Andrology-Open Access.
Carranza F Santamaría E González-Ravina C Blasco V Caligara C Fernández-Sánchez M
4 - 2, pp. 1 - 7. OMICS group, 2015.
Elective single versus double embryo transfer: live birth outcome and patient acceptance in a prospective randomised trial.
Quiroga R Caligara C Ruiz M Blasco V Pellicer A Fernández-Sánchez M
Reprod Fertil Dev, 27 (5): 794-800, 2015
Monozygotic twinning after assisted reproductive technologies: a case report of asymmetric development and incidence during 19 years in an international group of in vitro fertilization clinics.
Tocino A Blasco V Vargas MJ Requena A Pellicer A Fernández-Sánchez M
Fertil Steril, 103 (5): 1185-1189, 2015
Follicular and endocrine dose responses according to anti-Mullerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049).
Bosch E Nyboe Andersen A García-Velasco JA Sutter P Fernández-Sánchez M Visnova H Klein BM Mannaerts B Arce JC
Clin Endocrinol, 83 (6): 902-912, 2015
Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049).
Bosch E Nyboe Andersen A Barri P García-Velasco JA de Sutter P Fernández-Sánchez M Visnova H Klein BM Mannaerts B Arce JC
Clin Endocrinol (Oxf). 83:902-12, 2015.
Influence of follicle rupture and uterine contractions on intrauterine insemination outcome: a new predictive model.
Blasco V Carranza F González-Ravina C Pellicer A Fernández-Sánchez M
Fertil Steril, 102(4):1034-40, 2014.
Expression of neurokinin B/NK3 receptor and kisspeptin/KISS1 receptor in human granulosa cells.
García-Ortega J Pinto FM Fernández-Sánchez M Cejudo Román A Almeida TA Hernández M Romero M Tena-Sempere M Candenas L
Hum Reprod, 29:2736-46, 2014.
Ovarian response to recombinant human follicle-stimulating hormone: a randomized, antimüllerian hormone-stratified, dose-response trial in women undergoing in vitro fertilization/intracytoplasmic sper
Arce JC Andersen AN Fernández-Sánchez M Visnova H Bosch E García-Velasco JA Barri P de Sutter P Klein BM Fauser BC
Fertil Steril. 102:1633-40, 2014.
The voltage-gated sodium channel Nav1.8 is expressed in human sperm.
Cejudo Román A Pinto FM Subirán N Ravina CG Fernández-Sánchez M Pérez-Hernández N Pérez R Pacheco A Irazusta J Candenas L
PLoS One, 8:e76084, 2013.
Characterization of the kisspeptin system in human spermatozoa
Pinto FM Cejudo Román A González-Ravina C Fernández-Sánchez M Martín-Lozano D Illanes M Tena-Sempere M Candenas L
Int J Androl 35:63-73, 2012
The non-ergot derived dopamine agonist quinagolide in prevention of early ovarian hyperstimulation syndrome in IVF patients: a randomized, double-blind, placebo-controlled trial.
Busso C Fernández-Sánchez M García-Velasco JA Landeras J Ballesteros A Muñoz E González S Simón C Arce JC Pellicer A
Hum Reprod. 25:995-1004, 2010.
Autocrine regulation of human sperm motility by tachykinins
Pinto FM Ravina CG Subiran N Cejudo Román A Fernández-Sánchez M Irazusta J Garrido N Candenas L
Reprod Biol Endocrinol, 8:104, 2010.
Clinical Factors affecting endometrial receptiveness in oocyte donation cycles.
Soares SR García-Velasco JA Fernández-Sánchez M Bosch E Remohí J Pellicer A Simón C
Fertil Steril, 89(3):491-501, 2008
Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system.
Budak E Fernández-Sánchez M Bellver J Cerveró A Simón C Pellicer A
Fertil Steril, 85:1563-81, 2006.
- Simon C Gómez C Cabanillas S Vladimirov IK Castillón G Giles J Boynukalin FK Findikli N Ortega I Vidal C Izquierdo A Portela S Frantz N Taguchi S Labarta E Colucci F Mackens S Santamaría X Muñoz E Barrera SG Fernandez-Sanchez M Ferrando M Pellicer A Mol BW Valbuena D O-134 IN VITRO FERTILIZATION WITH PERSONALIZED BLASTOCYST TRANSFER VERSUS FROZEN OR FRESH BLASTOCYST TRANSFER: A MULTICENTER, RANDOMIZED CLINICAL TRIAL. Presented at 75th American Society of Reproductive Medicine Scientific Congress, Philadelphia, PA. USA, 14-16 October 2019
- Fernandez-Sanchez M Visnova H Yuzpe A Klein BM Mannaerts B Arce JC Individualization of the starting dose of gonadotropin reduces the overall ohss risk and the need of preventive cumulative data over three. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver, CO, USA, October 6-10, 2018
- González-Ravina C Cruz M Rubio C Fernández-Sánchez M Oquiñena E Ferrando R Requena A Polymorphic chromosome variants, human inversions, and their functional consequences in male infertility. Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology, Geneva,Switerland, July 2-5 ,2017
- Rubio Lluesa C Cruz M González-Ravina C Fernández-Sánchez M Oquiñena E Requena A Polymorphism on chromosome 21 does not affect ovarian reserve but clinical outcomes after in vitro fertilization treatments. Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology, Geneva,Switerland, July 2-5 ,2017