Diana Alecsandru, M.D., Ph.D.

Consultant Clinical Immunologist. Physician for Reproductive Immunology. Reproductive Immunology, Endocrinology and Infertility Unit.

IVI Madrid

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Diana Alecsandru, M.D., Ph.D.


Dr. Diana Alecsandru, M.D., PhD. is an attending physician at IVI Madrid where she serves as Consultant Clinical Immunologist Physician for Reproductive Immunology Services, Assistant Professor at Complutense University in the Department of Microbiology, Division of Immunology, and Professor of Master’s Degree in Human Reproduction at Rey Juan Carlos University, Complutense University, and European University in Madrid, Spain.

She received her medical degree from Carol Davila University Medical School in Bucharest, Romania. She completed her residency training in Clinical Immunology in San Carlos Hospital, La Paz Hospital, and Gregorio Marañon Hospital in Madrid and received her Immunology Certification from the Education and Health Ministry of Spain. She completed her Ph.D. in Medicine at Complutense University, focused in immunogenetics and her thesis research was awarded with the Extraordinary Ph.D. Award in Medicine Section at Complutense University, in Madrid, Spain.

Dr. Alecsandru completed her Clinical Immunology fellowship training at the Immunology Department of Royal Free Hospital, Jeffrey Modell Foundation, London. UK. Dr. Alecsandru completed her Reproductive Immunology training in Gregorio Marañon Hospital Madrid in the FIS –Carlos III Health Institute (Spain) program.
Dr. Alecsandru is a board certified Clinical Immunologist, and a board certified Reproductive Immunology Specialist. She is active in the Spanish College of Medicine. She is also a member of the European Society for Human Reproduction and Embryology (ESHRE), the European European Society of Reproductive Immunology (ESRI), the Spanish Fertility Society (SEF), and the Spanish Immunology Society (SEI).

Dr. Alecsandru has been invited to speak nationally and internationally and has authored and contributed to over 50 peer reviewed publications, published chapters and abstracts; she is the author for several textbooks on recurrent implantation failure. She serves on the Editorial Board for Obstetrics & Gynecology International Journal (OGIJ), and as Ad Hoc Reviewer for leading reproductive journals including Fertility and Sterility and Reproductive BioMedicine Online. Her research interests include early placentation, recurrent implantation failure, recurrent miscarriage, immuno-genetic and immunological factors involved in embryo implantation, impact of autoimmunity on ART outcome, effect of metabolic status on ART success. She is Investigator in projects funded by the Ministries of Education and Health in Spain.

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M.D. Carol Davila University Medical School Bucharest (1999)
Residency Clinical Immunology in San Carlos Hospital, La Paz Hospital and Gregorio Marañon Hospital in Madrid, Spain (2007)
PhD Complutense University. Madrid. Spain (2007)
Fellowship Reproductive Immunology training in Gregorio Marañon Hospital Madrid in the FIS –Carlos III Health Institute (Spain) program (2009)
Fellowship Immunology Department of Royal Free Hospital. Jeffrey Modell Foundation. London. UK. (2010)

Honores y reconocimientos

Extraordinary PhD Award in Medicine Section at Complutense University.Madrid, Spain 2007


  • Immune testing and treatment: still an open debate.
    Alecsandru D, García-Velasco JA.
    Hum Reprod, 2015.

  • Immunology and human reproduction.
    Alecsandru D, García-Velasco JA.
    Curr Opin Obstet Gynecol, 27(3):231-4, 2015.

  • Maternal KIR haplotype influence life birth rate after embryo transfer in vitro fertilization (IVF) cycles.
    D. Alecsandru, N. Garrido, J.L. Vicario, A. Barrio, P. Aparicio, A. Requena, JA. García-Velasco.
    Hum Reprod, 29(12):2637-43, 2014.

  • Experience in IVIg Therapy for Selected Women with Recurrent Reproductive Failure and NK Cell Expansion.
    Ramos-Medina R, García-Segovia A, Gil J, Carbone J, Aguarón de la Cruz A,
    Seyfferth A, Alonso B, Alonso J, León JA, Alecsandru D, Meliá E, Carrillo de
    Albornoz E, Ordoñez D, Santillán I, Verdú V, Garcia Ruiz de Morales JM, López-Hoyos M, López Larios A, Sampalo A, Caballero P, Ortiz Quintana L, Fernández-Cruz E, Sánchez-Ramón S.
    Am J Reprod Immunol, 2014.

  • Outcomes of splenectomy in patients with Common Variable Immunodeficiency (CVID): a survey of 45 patients.
    Wong, G; Goldacker, S; Winterhalter, C; Grimbacher, B; Chapel, H M; Lucas, Mary; D. Alecsandru; McEwen, D; Quinti, I; Martini, H Milito, Cinzia; Schmidt, R; Ernst, D; Espanol,T; Vidaller, A.
    Clin Exp Immunol, 172(1):63-72, 2013.

  • Intravenous immunoglobulin treatment increases live birth rate in a Spanish cohort of women with recurrent reproductive failure and expanded CD56+ cells.
    M Moraru, J Carbone, D. Alecsandru, M Castillo-Rama, A García-Segovia, J
    Gil, Alonso, Bárbara, A Aguarón, J Martínez De María, D Oliver-Miñarro, M Rodríguez-Mahou, V Ortega, P Caballero, E Meliá, M Cianchetta-Sivori, C Esteban, L Henny, J Dale, E Fernández-Cruz, S Sánchez-Ramón.
    Am J Reprod Immunol, 18.1600-0897, 2012.

  • Sublingual therapeutic immunization with a polyvalent bacterial preparation in patients with recurrent respiratory infections: immunomodulatory effect on the proliferating capacity of specific CD4+ T cells and impact on clinical outcome.
    D. Alecsandru, L. Valor, S. Sánchez-Ramón, J. Gil, J. Carbone, Javier; Navarro, Joaquin, Rodriguez, Juan Jose; Rodriguez Sainz, Carmen; Fernández- Cruz,E. Fernández-Cruz.
    Clin Exp Immuno , 164(1):100–7, 2011.

  • Severe Refractory Hidradenitis Suppurativa in HIV-Positive Patient Successfully Treated with Infliximab.
    D. Alecsandru, Belén Padilla, José Antonio Avilés Izquierdo, E. Fernández- Cruz, and S. Sánchez-Ramón.
    Archives of Dermatology. Dec; 146(12):1343-5.2010

  • Non-Traumatic Metatarsal Fracture in Primary Antiphospholipid Syndrome.
    D. Alecsandru, E. Fernandez-Cruz, J .Carbone MD.
    Revista Clínica Española, 2010.

  • Prognostic value of peripheral blood mononuclear cell-associated HIV-1 DNA for virological outcome in asymptomatic HIV-1 chronic infection.
    Rodríguez-Sáinz C, Ramos R, Valor L, López F, Santamaría B, Hernández DC,
    Cruz JS, Navarro J, Modrego J, Alecsandru D, Fernández-Cruz E.
    J Clin Virol, 2010.

  • Mechanism of action of immune globulin.
    E. Fernández-Cruz, D. Alecsandru, S. Sánchez-Ramón.
    Clinical Experimental Immunology, 157 (Suppl.1): 1-2, 2009.

  • Introducción a los fármacos biológicos.
    E. Fernández-Cruz, D. Alecsandru, C. Rodríguez-Sainz.
    Actas Dermosifiliogr, 99 Suppl 4:2-6, 2008.

  • Genetic Markers linked to Rheumatoid Arthritis are also strongly associated with Articular Manifestations in Ulcerative Colitis Patients.
    C. Núñez, DM Alecsandru, Juan Luis Mendoza, Elena Urcelay, Manuel Díaz-Rubio, Emilio Gómez de la Concha, Alfonso Martínez.
    Hum Immunol 67 (4-5):324-30, 2006.

  • Interleukin-10 haplotypes in Celiac Disease in the Spanish population.
    Nuñez C, Alecsandru D, Varade J, Polanco I, Maluenda C, Fernandez-Arquero M, G de la Concha E, Urcelay E, Martinez A.
    BMC Med Genet 31;7(1):32, 2006.

  • E.coli multiresistant meningitis after transrectal prostate biopsy.
    Alecsandru D, Gestoso I, Romero A, Martinez A, García A, Lobo J, Ruiz Yagüe M.
    Sci World J, 29; 6:2323-6, 2006.

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