James Hotaling, M.D.

Dr. Hotaling research interests in the genetic and epigenetic determinants of Infertility and Erectile Dysfunction, the impact of Male Infertility on individual and familial somatic health and microfluidic sperm sorting. He has over 100 publications, numerous book chapters and speaks regularly on these topics at national and international meetings. Dr. Hotaling obtained an MS in clinical epidemiology at the University of Washington and focused on applying the tools of statistical genetics to Erectile Dysfunction.

Since joining the University of Utah, he has been continuously funded by the NIH/NSF. Dr. Hotaling serves as a principal investigator (PI) on an R01 to study the genetics of Erectile Dysfunction and an NSF SSTR Phase I grant to examine microfluidic sperm sorting. He is also a Co-investigator (co-I) on two other R01s examining the trans-generational effects of smoking and the largest study in the world on the genetics of Male Infertility. He has also cofounded three companies in the Men’s Health/Male Infertility space and won multiple national awards for research.

His work on Male Infertility has centered on establishing a tissue bank of testicular tissue which now contains over 300 specimens as well as building a large (>50,000 infertile individuals linked to >500,000 relatives) infertility database through the Utah Population Database called SHARE: subfertility health assisted reproduction and the environment. SHARE is the largest repository of epidemiologic and pedigree based information on male infertility in the United States and, likely, the world. Multiple publications from this database have helped elucidate the impact of Male Infertility on individual and familial somatic health.