James Hotaling, M.D.

Biography

Dr. Hotaling is a fellowship-trained urologist specializing in Male Infertility and Men’s Health.He completed his undergraduate work at Dartmouth, graduating magna cum laude with a double major in history and biophysical chemistry. He then went to Duke for medical school and completed a 6-year residency at the University of Washington. Dr. Hotaling elected to pursue an additional year of training under Dr. Craig Niederberger at the University of Illinois at Chicago focusing on Male Infertility and Men’s Health. Here, he had extensive training in micro-surgery, including Testicular Sperm Extractions (TESE), Micro-dissection Testicular Sperm Extraction (microTESE), and Vasectomy Reversal. He is also one of the only Men’s Health and Infertility experts in the United States to have undergone additional training to become a Fellow of European College of Sexual Medicine (FECSM) as well as being a board certified urologist.

Dr. Hotaling research interests in the genetic and epigenetic determinants of Infertility and Erectile Dysfunction, the impact of Male Infertility on individual and familial somatic health and microfluidic sperm sorting. He has over 100 publications, numerous book chapters and speaks regularly on these topics at national and international meetings. Dr. Hotaling obtained an MS in clinical epidemiology at the University of Washington and focused on applying the tools of statistical genetics to Erectile Dysfunction.

Since joining the University of Utah, he has been continuously funded by the NIH/NSF. Dr. Hotaling serves as a principal investigator (PI) on an R01 to study the genetics of Erectile Dysfunction and an NSF SSTR Phase I grant to examine microfluidic sperm sorting. He is also a Co-investigator (co-I) on two other R01s examining the trans-generational effects of smoking and the largest study in the world on the genetics of Male Infertility. He has also cofounded three companies in the Men’s Health/Male Infertility space and won multiple national awards for research.

His work on Male Infertility has centered on establishing a tissue bank of testicular tissue which now contains over 300 specimens as well as building a large (>50,000 infertile individuals linked to >500,000 relatives) infertility database through the Utah Population Database called SHARE: subfertility health assisted reproduction and the environment. SHARE is the largest repository of epidemiologic and pedigree based information on male infertility in the United States and, likely, the world. Multiple publications from this database have helped elucidate the impact of Male Infertility on individual and familial somatic health.

Education and Training

B.A.	Dartmouth College (2002)
M.D.	Duke University School of Medicine (2006)
Intern	University of Washington School of Medicine (2007)
M.S.	University of Washington School of Public Health (2010)
Resident	University of Washington School of Medicine (2012)
Fellow	University of Illinois at Chicago School of Medicine, Department of Urology (2013)

Honors and recognition

AUA Early career investigator showcase presentation selected for podium	2017
American Urological Association Prize paper podium presentation for pediatric section	2016
Associate (speciality) editor of Fertility & Sterility	2016
ASA Poster selected as Best Poster: “Lower Semen Quality as a Marker For Increased Familial Mortality”	2015
Fertility & Sterility Reviewer of the Year Award	2015
Western Section of AUA Best Poster of meeting	2015
Fertility and Sterility Reviewer of the Year Award	2014
AUA Poster selected as Best Poster in Session: "The Male Orgasm"	2014
AUA Poster selected as Best Poster In Session: "Validity and Reliability of a Smartphone Application of the Assessment of Penile Deformity in Peyronie's Disease. Award of $5,000 from University of Illinois Enterprise Works for Sperm Dx Inc."	2013
Fertility & Sterility Reviewer of the Year Award	2013
SMRU Travelling Scholar $1000	2011
Hirschler Prize for Innovative Urologic Research: $4000 for: “UWPNS360”	2011
Warren Chapman Resident Research Award. University of Washington Department of Urology	2010
Northwest Institute of Genetic Medicine (NWIGM) Resource Grant for: “A Study of The Genetic Predictors of Erectile Dysfunction”.University of Washington Department of Urology	2010
AUA Poster Selected as Best Poster in Session: “Isolated Teratospermia does not appear to predict clinical pregnancy following in vitro fertilization or in vitro-fertilization with intracytoplasmic sperm injection: A systematic review and meta-analysis”. University of Washington Department of Urology	2010
AUA Annual Meeting Abstract selected for Meet the Press: “Long-term use of supplemental vitamin C, vitamin D and vitamin E does not reduce the risk of urothelial cell carcinoma of the bladder in the VITamins and Lifestyle study. University of Washington Department of Urology”	2010
Summer Institute in Statistical Genetics Training Scholarship: $2400. University of Washington Department of Urology	2010
Hirschler Prize for Innovative Urologic Research: $4000 for: “Sperm Cryopreservation Oncological Databank”. University of Washington Department of Urology	2009
International Volunteers in Urology Scholarship: $2500: to support travel to Uganda to work with Dr. Stephen Watya. University of Washington Department of Urology	2009
Hirschler Prize for Innovative Urologic Research: $2000 for: “Development of a prospective database to standardize and track trauma outcomes”. University of Washington Department of Urology	2009
American Urologic Association Western Section Resident Scholarship. University of Washington Department of Urology	2008

Publications

Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology.
Björndahl L, Barratt CLR, Mortimer D, Agarwal A, Aitken RJ, Alvarez JG, Aneck-Hahn N, Arver S, Baldi E, Bassas L, Boitrelle F, Bornman R, Carrell DT, Castilla JA, Cerezo Parra G, Check JH, Cuasnicu PS, Darney SP, de Jager C, De Jonge CJ, Drevet JR, Drobnis EZ, Du Plessis SS, Eisenberg ML, Esteves SC, Evgeni EA, Ferlin A, Garrido N, Giwercman A, Goovaerts IGF, Haugen TB, Henkel R, Henningsohn L, Hofmann MC, Hotaling JM, Jedrzejczak P, Jouannet P, Jørgensen N, Kirkman Brown JC, Krausz C, Kurpisz M, Kvist U, Lamb DJ, Levine H, Loveland KL, McLachlan RI, Mahran A, Maree L, Martins da Silva S, Mbizvo MT, Meinhardt A, Menkveld R, Mortimer ST, Moskovtsev S, Muller CH, Munuce MJ, Muratori M, Niederberger C, O'Flaherty C, Oliva R, Ombelet W, Pacey AA, Palladino MA, Ramasamy R, Ramos L, Rives N, Roldan ER, Rothmann S, Sakkas D, Salonia A, Sánchez-Pozo MC, Sapiro R, Schlatt S, Schlegel PN, Schuppe HC, Shah R, Skakkebæk NE, Teerds K, Toskin I, Tournaye H, Turek PJ, van der Horst G, Vazquez-Levin M, Wang C, Wetzels A, Zeginiadou T, Zini A

Hum Reprod.. Sep. 2022 doi: 10.1093/humrep/deac189

Seasonal variation in semen quality is not associated with fecundity in the Utah Population Database.
Patel DP, Cheng PJ, Hanson HA, Smith KR, Aston KI, Pastuszak AW, Hotaling JM

Andrologia. 2022 Jun 29:e14515. Online ahead of print. 2022 doi: 10.1111/and.14515

"The back-up vasectomy reversal." Simultaneous sperm retrieval and vasectomy reversal in the couple with advanced maternal age: a cost-effectiveness analysis.
Cheng PJ, Kim J, Craig JR, Alukal J, Pastuszak AW, Walsh TJ, Hotaling JM

Urology. Apr. 2021 doi: 10.1016/j.urology.2021.03.021

Round spermatid injection into human oocytes: a systematic review and meta-analysis.
Hanson BM, Kohn TP, Pastuszak AW, Scott R T, Cheng PJ, Hotaling JM

Asian J Androl. Feb. 2021 doi: 10.4103/aja.aja_85_20

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