Surgery

Areas of Investigation

Reproductive endocrinologists have traditionally been pioneers of minimally invasive reproductive and gynecologic surgery, with the ultimate goal of restoring normal anatomy in the gentlest manner possible in order to maximize chance of healthy pregnancy.

Research and development in this field has had a drastic impact on the physical and emotional burden of infertility patients and contributed to an improvement on overall quality of life. The application of hysteroscopic, laparoscopic and robotic surgery techniques have led to faster recoveries, less surgical risk and complications and improved reproductive outcomes.

As minimally invasive techniques become the mainstay of surgical approach, technological advancements are being explored to increase ease, accessibility and cost-effectiveness. In addition, who, what and when to operate remain the cornerstones of surgical investigation.

Investigators
working in this area

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Elena Labarta, M.D., Ph.D. Specialist in Human Reproduction and Assisted Reproductive Techniques at IVI Valencia IVI Valencia
James Hotaling, M.D. Urologist Specialist in Male Infertility and Men’s Health at RMA of new Jersey RMA New Jersey
Carmina Vidal, M.D., Ph.D. Gynecologist and Reproductive Medicine Specialist at IVI Valencia IVI Valencia
María Cerrillo, M.D., Ph.D. Reproductive Endocrinology and Infertility Specialist at IVI Madrid IVI Madrid
Juan Giles, M.D. Gynecologist at IVI Valencia and Clinical Researcher at the INCLIVA Institute IVI Valencia
Fabio Cruz, M.D. Gynecologist and Reproductive Medicine Specialist at IVI Valencia IVI Valencia
Roberto Matorras, M.D., Ph.D. Coordinator for Research and Education at IVI Bilbao IVI Bilbao
Cesar Diaz-Garcia Medical Director IVI London

Publications
from this area

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Transplantation of cryopreserved ovarian tissue in a series of 285 women: a review of five leading European centers. Dolmans MM, von Wolff M, Poirot C, Diaz-Garcia C, Cacciottola L, Boissel N, Liebenthron J, Pellicer A, Donnez J, Andersen CY Fertil Steril. May. 2021 doi: 10.1016/j.fertnstert.2021.03.008
Effects of Hydrosalpinx on Endometrial Implantation Failures: Evaluating Salpingectomy in Women Undergoing in vitro fertilization Palagiano A, Cozzolino M, Ubaldi FM, Palagiano C, Coccia ME Rev Bras Ginecol Obstet. Feb. 2021 doi: 10.1055/s-0040-1722155
Perceptions and Motivations for Uterus Transplant in Transgender Women. Jones BP, Rajamanoharan A, Vali S, Williams NJ, Saso S, Thum MY, Ghaem-Maghami S, Quiroga I, Diaz-Garcia C, Thomas P, Wilkinson S, Yazbek J, Smith JR JAMA Netw Open. Jan. 2021 doi: 10.1001/jamanetworkopen.2020.34561
Recurrent implantation failure: how common is it? Pirtea P, Scott R T, de Ziegler D, Ayoubi J M, Curr Opin Obstet Gynecol. Jun. 2021 doi: 10.1097/GCO.0000000000000698
Preimplantation genetic testing to evaluate for mitochondrial deoxyribonucleic acid disease and aneuploidy: a two-birds-with-one-stone approach Hanson B M, Seli E, Fertil Steril. Mar. 2021 doi: 10.1016/j.fertnstert.2021.03.006
Cesarean Section Scar Nodule, Ovarian Cyst, and Dysmenorrhea Gonçalves-Henriques M, Brandão P, Almeida A, Ramôa P, Journal of Medical Ultrasound. 2020 doi:
Supplementation with progestogens in the first trimester of pregnancy to prevent miscarriage in women with unexplained recurrent miscarriage: a systematic review and meta-analysis of randomized, controlled trials. Saccone G, Schoen C, Franasiak J M, Scott R T, Berghella V, Fertil Steril. 2017 doi:
The Use of Laparoscopy Simulation to Explore Gender Differences in Resident Surgical Confidence. Flyckt RL, White EE, Goodman L, Mohr C, Dutta S, Zanotti KM, Obstet Gynecol Int. 2017 doi:
Adenomyosis in infertile women: prevalence and the role of 3D ultrasound as a marker of severity of the disease Puente J M, Fabris A, Patel J, Patel A, Cerrillo M, Requena A, Garcia-Velasco J A, Reprod Biol Endocrinol. 20-Sep. 2016 doi: 10.1186/s12958-016-0185-6
Cardiovascular Autonomic Neuropathy, Sexual Dysfunction, and Urinary Incontinence in Women With Type 1 Diabetes. Hotaling J M, Sarma AV, Patel DP, Braffett BH, Cleary PA, Feldman E, Herman WH, Martin CL, Jacobson AM, Wessells H, Pop-Busui R, Martin CL, Diabetes Care. 2016 doi:
Effect of surgery on ovarian reserve in women with endometriomas, endometriosis and controls. Goodman L, Goldberg J, Flyckt RL, Gupta M, Harwalkar J, Falcone T, Am J Obstet Gynecol. 2016 doi:
Genetic mutation that may contribute to failure of prolapse surgery in Caucasian women: A case-control study. St Louis S, Scott R T, Lewis C, Salamon C, Pagnillo J, Treff N, Taylor D, Culligan P, J Minim Invasive Gynecol. 2016 doi:
Laparoscopic Vaginal-Assisted Hysterectomy with Complete Vaginectomy for Female-To-Male Genital Reassignment Surgery. Gomes da Costa A, Valentim-Lourenço A, Valentim-Lourenço A, Santos-Ribeiro S, Carvalho Afonso M, Henriques A, Ribeirinho AL, Decio Ferreira J, J Minim Invasive Gynecol. 2016 doi:
Surgical Management of Ureteral Strictures Arising From Radiotherapy for Prostate Cancer. Orchard J, Tward JD, Lenherr S, Hotaling J M, Brant WO, Myers JB, Urol Case Rep. 2016 doi:
Ergonomic Strain in Minimally Invasive Surgery: Addressing the Strain Epidemic. Franasiak J M, Gehrig P, J Clin Outcomes Management. 2015 doi:
Inherent difficulties of meta-analysis for surgical techniques in male infertility: an argument for standardizing reporting and outcomes. Anderson R, Hotaling J M, Fertil Steril. 2015 doi:
Introducing Larger Equipment: A Novel Method in Laparoscopic Surgery with Smaller Port Sites. Kim S, Goodman L, Goldberg J, J Minim Invasive Gynecol. 2015 doi:
Robotic single-site myomectomy: a step-by-step tutorial. Gargiulo A, Lewis E, Kaser D J, Srouji SS, Fertil Steril. 2015 doi:
Supraumbilical primary trocar insertion for laparoscopic access: the relationship between points of entry and retroperitoneal vital vasculature by imaging. Stanhiser J, Goodman L, Soto E, Al-Aref I, Wu J, Gojayev A, Nutter B, Falcone T, Am J Obstet Gynecol. 2015 doi:
Techniques for enclosed morcellation in gynecologic surgery. Srouji S, Kaser D J, Gargiulo AR, Fertil Steril. 2015 doi:
Trends Over Time and Surgical Outcomes of Abdominal, Mini-Laparotomy, and Traditional and Robotic-Assisted Laparoscopy With and Without Tandem Mini-Laparotomy: A Comparison of Myomectomy Techniques Stanhiser J, Mouille B, Flyckt R, Goldberg J, Falcone T, Goodman L, J Minim Invasive Gynecol. 2015 doi:
Demographics of pediatric renal trauma. Grimsby GM, Voelzke B, Hotaling J M, Sorensen MD, Koyle M, Jacobs MA, J Urol. 2014 doi:
Is there still a role for primary realignment for stricture due to pelvic fracture? Brant WO, Hotaling J M, J Urol. 2014 doi:
Management of adults with prior failed hypospadias surgery. Review. Craig JR, Wallis C, Brant WO, Hotaling J M, Myers JB, Transl Androl Urol. 2014 doi:
Pregnancy success after hysteroscopic sterilization reversal. Franasiak J M, Monteith C, Berger G, Zerden M, Obstetrics and Gynecology. 2014 doi:
Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform. Konstantinidis M, Alfarawati S, Hurd D, Paolucci M, Shovelton J, Fragouli E, Wells D, Fertil Steril. 2014 doi:
Additive effect of factors related to assisted conception on the reduction of maternal serum pregnancy-associated plasma protein A concentrations and the increased false-positive rates in first-trimester Down syndrome screening. Bellver J, Casanova C, Garrido N, Lara C, Remohi J, Pellicer A, Serra V, Fertil Steril. 2013 doi:
Contemporary trends in the immediate surgical management of renal trauma using a national database. McClung C, Hotaling J M, Wang J, Wessells H, Voelzke B, J Trauma Acute Care Surg. 2013 doi:
Ergonomic deficits in robotic gynecologic oncology surgery: A need for intervention. Craven R, Franasiak J M, Mosaly P, Gehrig PA, J Minim Invasive Gynecol. 2013 doi:
Outcomes of splenectomy in patients with Common Variable Immunodeficiency (CVID): a survey of 45 patients Wong G, Goldacker S, Winterhalter C, Grimbacher B, Chapel HM, Lucas M, Alecsandru D, McEwen D, Quinti I, Martini H , Milito C, Schmidt R, Ernst D, Espanol T, Vidaller A, McEwen D, Clin Exp Immunol. 2013 doi:
Publication misrepresentation among urology residency applicants. SHsi RS, Hotaling J M, Moore TN, Joyner BD, World J Urol. 2013 doi:
Undifferentiated round cell sarcoma of the broad ligament. Diaz-Murillo R, Iglesias C, Zapardiel I, Ecancermedicalscience. 2013 doi:
A national study of trauma level designation and renal trauma outcomes. Hotaling J M, Wang J, Sorensen MD, Rivara FP, Gore JL, Jurkovich J, McClung C, Wessells H, Voelzke BB, Wessells H, J Urol. 2012 doi:
Conservative management vs early surgery for high grade pediatric renal trauma--do nephrectomy rates differ? Jacobs MA, Hotaling J M, Mueller BA, Koyle M, Rivara F, Voelzke BB, J Urol. 2012 doi:
Do inclusive trauma systems improve outcomes after renal trauma? Vanni AJ, Hotaling J M, Hamlat C, Jurkovich GJ, Voelzke BB, J Trauma Acute Care Surg. 2012 doi:
Physical Strain and Urgent Need for Ergonomic Training Among Gynecologic Oncologists who Perform Minimally Invasive Surgery. Franasiak J M, Ko E, Kidd J, Alvarez-Secord A, Bell M, Boggess J, Gehrig P, Gynecol Oncol. 2012 doi:
Analysis of diagnostic angiography and angioembolization in the acute management of renal trauma using a national data set. Hotaling J M, Sorensen MD, Smith TG 3rd, Rivara FP, Wessells H, Voelzke BB, J Urol. 2011 doi:
Effect of collecting duct histology on renal cell cancer outcome. Wright JL, Risk MC, Hotaling J M, Lin DW, J Urol. 2009 doi:
Removal of endometriomas before in vitro fertilization does not improve fertility outcomes: a matched, case-control study Garcia-Velasco J A, Mahutte N G, Corona J, Zuniga V, Giles J, Arici A, Pellicer A, Fertil Steril. May. 2004 doi: 10.1016/j.fertnstert.2003.04.006
Surgery for the removal of endometriomas before in vitro fertilization does not increase implantation and pregnancy rates Garcia-Velasco J A, Arici A, Fertil Steril. May. 2004 doi: 10.1016/j.fertnstert.2003.10.032
Bilateral partial oophorectomy in the management of severe ovarian hyperstimulation syndrome (OHSS): ovarian mutilating surgery is not an option in the management of severe OHSS Bellver J, Escudero E, Pellicer A, Hum Reprod. Jul. 2003 doi: 10.1093/humrep/deg285
Erectile dysfunction after radical prostatectomy: hemodynamic profiles and their correlation with the recovery of erectile function Mulhall JP, Slovick R, Hotaling J M, Aviv N, Valenzuela R, Waters WB, Flanigan RC, J Urol. 2002 doi:
Chronology of venous leak development following radical prostatectomy. Hotaling J M, Mulhall JP, J Urol. 1999 doi:
Growth-regulated gene a expression in human peritoneal environment with endometriosis. Oral E, Seli E, Bahtiyar MO, Olive DL, Arici A, Obstet Gynecol. 1996 doi:
Premature luteinization during controlled ovarian hyperstimulation for in vitro fertilization-embryo transfer has no impact in pregnancy outcome. Hofmann GE, Khoury J, Johnson CA, Thie J, Scott R T, Fertil Steril. 1996 doi:

Presentations
from this area

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ASRM 2018 Ovarian stimulation doesn’t influence the uterine immune environment in healthy infertile women Alecsandru D Pacheco A Fabris A Barrio A Aparicio P García-Velasco J Presented at the 73rd annual meeting of the American Society of Reproductive Medicine Delayed blastulation is linked with changes at early cleavage stage detected by continuous embryo monitoring Perez-Albal S Aparicio Ruiz B Galan Rivas A Alegre L Meseguer M Presented at the 73rd annual meeting of the American Society of Reproductive Medicine Improvement in reproductive outcome through artificial oocyte activation on fertilization failure cases: a cohort study Tejera A Alegre L Castello D Mifsud A Meseguer M Presented at the 73rd annual meeting of the American Society of Reproductive Medicine

ASRM 2018

Ovarian stimulation doesn’t influence the uterine immune environment in healthy infertile women
Alecsandru D Pacheco A Fabris A Barrio A Aparicio P García-Velasco J
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Delayed blastulation is linked with changes at early cleavage stage detected by continuous embryo monitoring
Perez-Albal S Aparicio Ruiz B Galan Rivas A Alegre L Meseguer M
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Improvement in reproductive outcome through artificial oocyte activation on fertilization failure cases: a cohort study
Tejera A Alegre L Castello D Mifsud A Meseguer M
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine

Areas of Investigation

Surgery

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Publications from this area

Presentations from this area

ASRM 2018

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