Surgery

Reproductive endocrinologists have traditionally been pioneers of minimally invasive reproductive and gynecologic surgery, with the ultimate goal of restoring normal anatomy in the gentlest manner possible in order to maximize chance of healthy pregnancy.

Research and development in this field has had a drastic impact on the physical and emotional burden of infertility patients and contributed to an improvement on overall quality of life. The application of hysteroscopic, laparoscopic and robotic surgery techniques have led to faster recoveries, less surgical risk and complications and improved reproductive outcomes.

As minimally invasive techniques become the mainstay of surgical approach, technological advancements are being explored to increase ease, accessibility and cost-effectiveness. In addition, who, what and when to operate remain the cornerstones of surgical investigation.

Investigators working in this area

Linnea Goodman, M.D.

Obstetrician and Gynecologist at RMA of New Jersey

RMA New Jersey

Elena Labarta, M.D., Ph.D.

Specialist in Human Reproduction and Assisted Reproductive Techniques at IVI Valencia

IVI Valencia

James Hotaling, M.D.

Urologist Specialist in Male Infertility and Men’s Health at RMA of new Jersey

RMA New Jersey

Human Fatemi, M.D., Ph.D.

Medical Director of the IVI Middle East

IVI Middle East

Carmina Vidal, M.D., Ph.D.

Gynecologist and Reproductive Medicine Specialist at IVI Valencia

IVI Valencia

María Cerrillo, M.D., Ph.D.

Reproductive Endocrinology and Infertility Specialist at IVI Madrid

IVI Madrid

Juan Giles, M.D.

Gynecologist at IVI Valencia and Clinical Researcher at the INCLIVA Institute

IVI Valencia

Fabio Cruz, M.D.

Gynecologist and Reproductive Medicine Specialist at IVI Valencia

IVI Valencia

Laura Melado Vidales, M.D., Ph.D.

IVF specialist IVI Middle East

IVI Middle East

Roberto Matorras, M.D., Ph.D.

Coordinator for Research and Education at IVI Bilbao

IVI Bilbao

Perceptions and Motivations for Uterus Transplant in Transgender Women.
Jones BP Rajamanoharan A Vali S Williams NJ Saso S Thum MY Ghaem-Maghami S Quiroga I Diaz-Garcia C Thomas P Wilkinson S Yazbek J Smith JR
JAMA Netw Open. 2021 Jan 4;4(1):e2034561. doi: 10.1001/jamanetworkopen.2020.34561.
Effects of Hydrosalpinx on Endometrial Implantation Failures: Evaluating Salpingectomy in Women Undergoing in vitro fertilization.
Palagiano A Cozzolino M Ubaldi FM Palagiano C Coccia ME
Rev Bras Ginecol Obstet. 2021 Feb 18. doi: 10.1055/s-0040-1722155. Online ahead of print.
Endometrial scratching can be offered outside clinical research setting: let us show you why.
Vitagliano A Di Spiezio Sardo A Noventa M Carugno J Cicinelli E Pacheco LA Vitale SG Campo R Laganà AS Haimovich S Cozzolino M Greco P
Hum Reprod. 2021 Mar 20:deab060. doi: 10.1093/humrep/deab060. Online ahead of print.
Cesarean Section Scar Nodule, Ovarian Cyst, and Dysmenorrhea
Gonçalves?Henriques M Brandão P Almeida A Ramôa P
Journal of Medical Ultrasound 2020
Uterine Transplantation; Review of Livebirths and Reproductive Implications.
Jones BP Kasaven L Vali S Saso S Jalmbrant M Bracewell-Milnes T Thum MY Quiroga I Friend P Diaz-Garcia C Ghaem-Maghami S Yazbek J Lees C Testa G Johannesson L Jones B Smith JR.
Transplantation. 2020 Dec 10. doi: 10.1097/TP.0000000000003578. Online ahead of print.
Personalized Medicine for allergy treatment: allergen immunotherapy still a unique and unmatched model.
Incorvaia C Al-Ahmad M Ansotegui I Arasi S Bachert C Bos C Bousquet J Bozek A Caimmi D Calderón M Casale T Custovic A De Blay F Demoly P Devillier P Didier A Fiocchi A Fox A Gevaert P Gomez M Heffler E Ilina NIrani C Jutel M Karagiannis E Klimek L Kuna P O'Hehir R Kurbacheva O Matricardi PM Morais de Almeida M Mosges R Novak N Okamoto Y Panzner P Papadopoulos N Park HS Passalacqua G Pawankar R
Allergy. 2020 Sep 1. doi: 10.1111/all.14575. Online ahead of print.
Septate uterus and reproductive outcomes: let's get serious about this.
Alonso Pacheco L Ata B Bettocchi S Campo R Carugno J Checa MA de Angelis C Di Spiezio Sardo A Donnez J Farrugia M Ferro J Franchini M Garzon S Gianaroli L Gergolet M Gubbini G Gordts S Grimbizis G Haimovich S Laganà AS Li TC Mencaglia LRienzi L Saravelos S Soares SR Tanos V Ubeda A Ubaldi FM Van Herendael B Vereczkey A Vitagliano A Vitale SG Zullo F
Hum Reprod. 2020 Sep 24:deaa230. doi: 10.1093/humrep/deaa230. Online ahead of print.
Good practice recommendations for the use of time-lapse technology.
ESHRE Working group on Time-lapse technology Apter S Ebner T Freour T Guns Y Kovacic B Le Clef N Marques M Meseguer M Montjean D Sfontouris I Sturmey R Coticchio G
Hum Reprod Open. 2020 Mar 19;2020(2):hoaa008. doi: 10.1093/hropen/hoaa008. eCollection 2020.
The vaginal microbiome in uterine transplantation.
Jones BP Soso S L'Heveder A Bracewell-Milnes T Thum MY Diaz-Garcia C Maclntyre DA Quiroga I Ghaem-Maghami S Testa G Johannesson L Bennett PR Yazbek J Smith JR
BJOG. 2019 Aug 8. doi: 10.1111/1471-0528.15881. [Epub ahead of print] Review.
Human uterine transplantation: a review of outcomes from the first 45 cases.
Jones BP Soso S Bracewell-Milnes T Thum MY Nicopoullos J Diaz-Garcia C Friend P Ghaem-Maghami S Johannesson L Quiroga l Yazbek J Smith JR
BJOG. 2019 Aug 13. doi: 10.1111/1471-0528.15863. [Epub ahead of print] Review.

Congenital Uterine Malformation by Experts (CUME): T-shaped uterus.
Ludwin A Coelho Neto MA Ludwin I Nastri CO Acién M Alcazar JL Benacerraf B Condous G DeCherney A De Wilde RL Diamond MP Emanuel MH Guerriero S Hurd W Levine D Lindheim S Pellicer A Petraglia F Saridogan E Matins WP
Ultrasound Obstet Gynecol. 2019 Aug 20. doi: 10.1002/uog.20845. [Epub ahead of print]
Rethinking the time interval to embryo transfer after uterus transplantation - DUETS (Dallas UtErus Transplant Study).
Johannesson L Wall A Putman JM Zhang L Testa G Diaz-Garcia C
BJOG. 2019 Jul 8. doi: 10.1111/1471-0528.15860. [Epub ahead of print]
Dexamethasone does not prevent malignant cell reintroduction in leukemia patients undergoing ovarian transplant: risk assessment of leukemic cell transmission by a xenograft model.
Diaz-Garcia C Herraiz S Such E Andrés MM Villamón E Mayordomo-Aranda E Cervera J Sanz MA Pellicer A
Hum Reprod. 2019 Jul 24. pii: dez115. doi: 10.1093/humrep/dez115. [Epub ahead of print]
Reproductive outcomes after hysteroscopic metroplasy for women with dysmorphic uterus and recurrent implantation failure
Ferro J Labarta E Saenz C Montoya P Remohí J
Facts Views Vis Obgyn 2019, 63-68
Uterus transplantation from a deceased donor.
Diaz-Garcia C Pellicer A
Lancet. 2018 Dec 4. pii: S0140-6736(18)32106-8. doi: 10.1016/S0140-6736(18)32106-8. [Epub ahead of print] No abstract available.
Uterus Transplantation: A Rapidly Expanding Field.
Brännström M Dahm Kähler Greite R Mölne J Diaz-Garcia C Tullius SG
Transplantation, 102(4):569-577, 2018.
Hysteroscopic septum resection and reproductive medicine: A SWOT analysis.
Spanish Infertility SWOT Group (SISG) Checa MA Bellver J Bosch E Espinós JJ Fabregues F Fontes J García-Velasco JA Requena A
Reprod Biomed Online, 37(6):709-715, 2018.
Anti-müllerian Hormone During Natural Cycle Presents Significant Intra and Intercycle Variations When Measured With Fully Automated Assay.
Melado L Lawrenz B Sibal J Abu E Coughlan C Navarro AT Fatemi HM
Front Endocrinol (Lausanne), 9:686-692, 2018.
The Status of Genetic Screening in Recurrent Pregnancy Loss.
Kaser DJ
Obstet Gynecol Clin North Am, 45(1):143-154, 2018.
Human sperm testicular angiotensin-converting enzyme helps determine human embryo quality
Gianzo M Urizar-Arenaza I Muñoa-Hoyos I Larreategui Z Garrido N Casis L Irazusta J Subirán N
Asian J Androl, 20(5):498-504, 2018.
Urethral Strictures and Artificial Urinary Sphincter Placement. [Review]
Myers JB Brant WO Hotaling J Lenherr SM
Urol Clin North Am, 44(1), 93-103, 2017.
Versatility of the suprapubic port in robotic assisted laparoscopic myomectomy.
Gueye NA Goodman L Falcone T
Fertil Steril. 2017 Sep;108(3).
The Use of Laparoscopy Simulation to Explore Gender Differences in Resident Surgical Confidence.
Flyckt RL White EE Goodman L Mohr C Dutta S Zanotti KM
Obstet Gynecol Int. 2017;2017:1945801.
Ovarian transposition: a surgical option for fertility preservation.
Arian SE Goodman L Flyckt RL Falcone T
BJOG. 2017 Apr 22.
Supplementation with progestogens in the first trimester of pregnancy to prevent miscarriage in women with unexplained recurrent miscarriage: a systematic review and meta-analysis of randomized, controlled trials.
Saccone G Schoen C Franasiak JM Scott RT Berghella V
Fertil Steril, 107:430-438, 2017.
Laparoscopic Vaginal-Assisted Hysterectomy with Complete Vaginectomy for Female-To-Male Genital Reassignment Surgery.
Gomes da Costa A Valentim-Lourenço A Valentim-Lourenço A Santos-Ribeiro S Carvalho Afonso M Henriques A Ribeirinho AL Décio Ferreira J
J Minim Invasive Gynecol 2016;23(3):404-9
Adenomyosis in infertile women: prevalence and the role of 3D ultrasound as a marker of severity of the disease.
Puente J Fabris A Patel J Patel A Cerrillo M Requena A García-Velasco JA
Reprod Biol Endocrinol 2016; 14: 60
Effect of surgery on ovarian reserve in women with endometriomas, endometriosis and controls.
Goodman L Goldberg J Flyckt RL Gupta M Harwalkar J Falcone T
Am J Obstet Gynecol. 2016 Nov;215(5):589.e1-589.e6.
Hysteroscopy before IVF: can it improve outcomes?
Pellicer A Galliano D
Lancet; 387 (10038): 2578-2579, 2016.
Assisted reproductive techniques after fertility-sparing treatments in gynaecological cancers
Zapardiel I Cruz M Diestro MD Requena A García-Velasco JA
Hum Reprod Update, 22, 2016.
Adenomyosis in infertile women: prevalence and the role of 3D ultrasound as a marker of severity of the disease
Puente J Fabris A Patel J Patel A Cerrillo M Requena A García-Velasco JA
Reprod Biol Endocrinol, 14(1):60, 2016
Surgical Management of Ureteral Strictures Arising From Radiotherapy for Prostate Cancer.
Orchard J Tward JD Lenherr S Hotaling J Brant WO Myers JB
Urol Case Rep, 6, 47-9, 2016.
Cardiovascular Autonomic Neuropathy, Sexual Dysfunction, and Urinary Incontinence in Women With Type 1 Diabetes.
Hotaling J Sarma AV Patel DP Braffett BH Cleary PA Feldman E Herman WH Martin CL Jacobson AM Wessells H Pop-Busui R
Diabetes Care, 39(9), 1587-93, 2016.
Genetic mutation that may contribute to failure of prolapse surgery in Caucasian women: A case-control study.
St Louis S Scott RT Lewis C Salamon C Pagnillo J Treff N Taylor D Culligan P
J Minim Invasive Gynecol, 23:726-30, 2016.
Trends Over Time and Surgical Outcomes of Abdominal, Mini-Laparotomy, and Traditional and Robotic-Assisted Laparoscopy With and Without Tandem Mini-Laparotomy: A Comparison of Myomectomy Techniques
Stanhiser J Mouille B Flyckt R Goldberg J Falcone T Goodman L
J Minim Invasive Gynecol. 2015 Nov-Dec;22(6S):S1.
Supraumbilical primary trocar insertion for laparoscopic access: the relationship between points of entry and retroperitoneal vital vasculature by imaging.
Stanhiser J Goodman L Soto E Al-Aref I Wu J Gojayev A Nutter B Falcone T
Am J Obstet Gynecol. 2015 Oct;213(4):506.e1-5
Introducing Larger Equipment: A Novel Method in Laparoscopic Surgery with Smaller Port Sites.
Kim S Goodman L Goldberg J
J Minim Invasive Gynecol. 2015 Nov-Dec;22(6S):S136
Ergonomic Strain in Minimally Invasive Surgery: Addressing the Strain Epidemic.
Franasiak JM Gehrig P
J Clin Outcomes Management, Vol 22 (6), 2015.
Inherent difficulties of meta-analysis for surgical techniques in male infertility: an argument for standardizing reporting and outcomes.
Anderson R Hotaling J
Fertil Steril, 104(5), 1127-8, 2015.
Robotic single-site myomectomy: a step-by-step tutorial.
Gargiulo A Lewis E Kaser DJ Srouji SS
Fertil Steril, 104(5):e13. 2015.
Techniques for enclosed morcellation in gynecologic surgery.
Srouji S Kaser DJ Gargiulo AR
Fertil Steril103:e34. 2015.
Time-lapse in the IVF lab: how should we assess potential benefit?
Basile N Barriere P Meseguer M Freour T
Hum Reprod, 30:1276-1276, 2015.
Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform.
Konstantinidis M Alfarawati S Hurd D Paolucci M Shovelton J Fragouli E Wells D
Fertil Steril, 102:13851392, 2014.
Pregnancy success after hysteroscopic sterilization reversal.
Franasiak JM Monteith C Berger G Zerden M
Obstetrics and Gynecology 124(6):1183-9, 2014. recognized for editorial assistance.
Demographics of pediatric renal trauma.
Grimsby GM Voelzke B Hotaling J Sorensen MD Koyle M Jacobs MA
J Urol, 192(5), 1498-502, 2014.
Management of adults with prior failed hypospadias surgery. [Review].
Craig JR Wallis C Brant WO Hotaling J Myers JB
Transl Androl Urol, 3(2), 196-204, 2014.
Is there still a role for primary realignment for stricture due to pelvic fracture?
Brant WO Hotaling J
J Urol, 192(6), 1595-6, 2014.
Outcomes of splenectomy in patients with Common Variable Immunodeficiency (CVID): a survey of 45 patients
Wong G Goldacker S Winterhalter C Grimbacher B Chapel HM Lucas M Alecsandru D McEwen D Quinti I Martini H Milito C Schmidt R Ernst D Espanol T Vidaller A
Clin Exp Immunol, 172(1):63-72, 2013.
Undifferentiated round cell sarcoma of the broad ligament.
Diaz-Murillo R Iglesias C Zapardiel I
Ecancermecialscience, 9;7:303, 2013.
Ergonomic deficits in robotic gynecologic oncology surgery: A need for intervention.
Craven R Franasiak JM Mosaly P Gehrig PA
J Minimal Inv Gynecol 20:648-55, 2013. Authors contributed equally.
Additive effect of factors related to assisted conception on the reduction of maternal serum pregnancy-associated plasma protein A concentrations and the increased false-positive rates in first-trimester Down syndrome screening.
Bellver J Casanova C Garrido N Lara C Remohí J Pellicer A Serra V
Fertil Steril, 100:1314-1320.e3, 2013.
Publication misrepresentation among urology residency applicants.
SHsi RS Hotaling J Moore TN Joyner BD
World J Urol, 31(3), 697-702, 2013.
Contemporary trends in the immediate surgical management of renal trauma using a national database.
McClung C Hotaling J Wang J Wessells H Voelzke B
J Trauma Acute Care Surg, 75(4), 602-606, 2013
Physical Strain and Urgent Need for Ergonomic Training Among Gynecologic Oncologists who Perform Minimally Invasive Surgery.
Franasiak JM Ko E Kidd J Alvarez-Secord A Bell M Boggess J Gehrig P
Gynecol Oncol, 126:437, 42, 2012.
Is there a benefit for surgery in endometrioma-associated infertility?
Ruiz-Flores FJ García-Velasco JA
Curr Opin Obstet Gynecol. 24:136-40, 2012.
Do inclusive trauma systems improve outcomes after renal trauma?
Vanni AJ Hotaling J Hamlat C Jurkovich GJ Voelzke BB
J Trauma Acute Care Surg, 72(2), 385-9, 2012.
A national study of trauma level designation and renal trauma outcomes.
Hotaling J Wang J Sorensen MD Rivara FP Gore JL Jurkovich J McClung C Wessells H Voelzke BB
J Urol, 187(2), 536-41, 2012.
Conservative management vs early surgery for high grade pediatric renal trauma--do nephrectomy rates differ?
Jacobs MA Hotaling J Mueller BA Koyle M Rivara F Voelzke BB
J Urol, 187(5), 1817-22, 2012.
Analysis of diagnostic angiography and angioembolization in the acute management of renal trauma using a national data set.
Hotaling J Sorensen MD Smith TG 3rd Rivara FP Wessells H Voelzke BB
J Urol, 185(4), 1316-20, 2011.
Effect of collecting duct histology on renal cell cancer outcome.
Wright JL Risk MC Hotaling J Lin DW
J Urol, 182(6), 2595-9, 2009.
Surgery for the removal of endometriomas before in vitro fertilization does not increase implantation and pregnancy rates.
García-Velasco JA Arici A
Fertil Steril. 81:1206, 2004.
Removal of endometriomas before in vitro fertilization does not improve fertility outcomes: a matched, case-control study.
García-Velasco JA Mahutte NG Corona J Zúñiga V Gilés J Arici A Pellicer A
Fertil Steril. 81:1194-7, 2004
Bilateral partial oophorectomy in the management of severe ovarian hyperstimulation syndrome (OHSS): ovarian mutilating surgery is not an option in the management of severe OHSS.
Bellver J Escudero E Pellicer A
Hum Reprod, 18:1363-7, 2003.
Erectile dysfunction after radical prostatectomy: hemodynamic profiles and their correlation with the recovery of erectile function
Mulhall JP Slovick R Hotaling J Aviv N Valenzuela R Waters WB Flanigan RC
J Urol, 167(3), 1371-5, 2002.
Chronology of venous leak development following radical prostatectomy.
Hotaling J Mulhall JP
J Urol, 16(4), 1055A, 1999.
Premature luteinization during controlled ovarian hyperstimulation for in vitro fertilization-embryo transfer has no impact in pregnancy outcome.
Hofmann GE Khoury J Johnson CA Thie J Scott RT
Fertil Steril, 66:980-6, 1996.
Growth-regulated gene a expression in human peritoneal environment with endometriosis.
Oral E Seli E Bahtiyar MO Olive DL Arici A
Obstet Gynecol 88:1050-56, 1996.

ASRM 2018
Alecsandru D Pacheco A Fabris A Barrio A Aparicio P García-Velasco J Ovarian stimulation doesn’t influence the uterine immune environment in healthy infertile women Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Perez-Albal S Aparicio Ruiz B Galan Rivas A Alegre L Meseguer M Delayed blastulation is linked with changes at early cleavage stage detected by continuous embryo monitoring Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Tejera A Alegre L Castello D Mifsud A Meseguer M Improvement in reproductive outcome through artificial oocyte activation on fertilization failure cases: a cohort study Presented at the 73rd annual meeting of the American Society of Reproductive Medicine

Surgery

Investigators working in this area

Publications from this area

Presentations from this area

ASRM 2018