Immunology
The association between the immune system and reproductive function has long been an attractive target in research. Unfortunately, much of the early work has been misguided leading to premature implementation of therapeutic measures. Thus, a return to the drawing board approach is necessary.
There is renewed interest in foundational research to further our understanding of the immune interaction between the embryo and the endometrium. These studies will likely give new life to research in reproductive immunology. Building upon this foundational work will allow for more artful manipulation of the immune system to improve reproductive outcomes.
Investigators working in this area
Publications from this area
- Anti-Müllerian hormone is an independent marker for oocyte survival after vitrification.
Melado L Arnanz A Bayram A Elkhatib I De Munck N Navarro AT Coughlan C Lawrenz B Fatemi HM
Reprod Biomed Online. 2020 Jul;41(1):119-127. doi: 10.1016/j.rbmo.2020.03.014. Epub 2020 Apr 28.
- Macrophages display proinflammatory phenotypes in the eutopic endometrium of women with endometriosis with relevance to an infectious etiology of the disease.
Vallvé-Juanico J Santamaría X Vo KC Houshdaran S Giudice LC
Fertil Steril. 2019 Dec;112(6):1118-1128. doi: 10.1016/j.fertnstert.2019.08.060.
- Ovarian Stimulation (OS) Does Not Influence the Uterine Immune Environment in Healthy Infertile Women
D. Alecsandru A. Pacheco A. Guerrero-Mayo A. Fabris P. Aparicio A. Barrio Pellicer A Juan A García-Velasco
Reproductive BioMedicine Online, In press, journal pre-proof, Available online 22 August 2019
- Understanding the role of killer cell immunoglobulin-like receptors in pregnancy complications.
Díaz-Peña R de Los Santos MJ Lucia A Castro-Santos P
J Assist Reprod Genet. 2019 Mar 7. doi: 10.1007/s10815-019-01426-9. [Epub ahead of print] Review.
- Tacrolimus Improves the Implantation Rate in Patients with Elevated Th1/2 Helper Cell Ratio and Repeated Implantation Failure (RIF).
Bahrami-Asl Z Farzadi L Fattahi A Yousefi M Quinonero A Hakimi P Latifi Z Nejabati HR Ghasemnejad T Sadigh AR Heidari MH Nouri M MG N Dominguez F
Geburtshilfe Frauenheilkd. 2020 Aug;80(8):851-862. doi: 10.1055/a-1056-3148. Epub 2020 Aug 14.
- Parental human leukocyte antigen-C allotypes are predictive of live birth rate and risk of poor placentation in assisted reproductive treatment.
Alecsandru D Barrio A Garrido N Aparicio P Pellicer A Moffett A García-Velasco JA
Fertil Steril. 2020 Jul 30:S0015-0282(20)30443-X. doi: 10.1016/j.fertnstert.2020.05.008. Online ahead of print.
- Is there a role for human leukocyte antigen-G typing in infertility treatment?
Alecsandru D Garcia-Velasco JA
Fertil Steril. 2020 Aug 5:S0015-0282(20)30624-5. doi: 10.1016/j.fertnstert.2020.06.048. Online ahead of print.
- Comparison of different sources of platelet-rich plasma as treatment option for infertility-causing endometrial pathologies
Miguel–Gómez L López-Martínez S Campo H Francés-Herrero E Amparo Faus Ana Díaz Pellicer A Domínguez F Cervelló I
Fertility and SterilityIn press, corrected proofAvailable online 24 August 2020
- A 300°IR sublingual tablet is an effective, safe treatment for house-dust-mite-induced allergic rhinitis: an international, double-blind, placebo-controlled, randomized Phase III clinical trial.
Demoly P Corren J Creticos P De Blay F Gevaert P Hellings P Kowal K Le Gall M Nenasheva N Passalacqua G Pfaar O Tortajada-Girbés M Vidal C Worm M Casale TB
J Allergy Clin Immunol. 2020 Sep 2:S0091-6749(20)31221-5. doi: 10.1016/j.jaci.2020.07.036. Online ahead of print.
- Pancreatic autoimmunity: An unknown etiology on patients with assisted reproductive techniques (ART)-recurrent reproductive failure.
Alecsandru D Barrio A Andia V Cruz E Aparicio P Serna J Cruz M Pellicer A García-Velasco JA
PLoS One, 13(10):NA-NA, 2018.
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Presentations from this area
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Prados N González-Ravina C Vergara V Javier Herrero Cruz M Requena A P-980 RISK FACTOR ANALYSIS FOR SARS-COV-2 SEROPOSITIVITY WITHIN ASSISTED REPRODUCTIVE Presented at 76th American Society of Reproductive Medicine Scientific Congress
ASRM2020
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Abdala A Elkhatib I A?ina Bayram Ana Arnanz Ahmed El-Damen Lawrenz B Fatemi HM De Munck N
P-764 IMPACT OF SLIGHT VARIATIONS OF EXTRACELLULAR CULTURE MEDIA pH (PHE) ON EMBRYO QUALITY, EUPLOIDY RATES AND MITOCHONDRIAL DNA (mtDNA).
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Alecsandru D Pacheco A Garrido N Barrio A Aparicio P Pellicer A Garcia-Velasco JA An increased % of CD56+CD16+ NK cells in the endometrial biopsy is not related with recurrent miscarriage when maternal KIR are considered Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2020
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Meseguer M O-9 Would an automated system detecting embryo developmental events select the same embryo as an embryologist using a morphokinetic algorithm? Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2019
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Lara-Molina EE Franasiak JM Marin D Devesa Peiro A Lopez Nogueroles M Florensa Bargallo M Martin Salat M Tao X Seli E Díaz Gimeno P Pellicer A P-584: Cumulus cell telomere length is associated with vitamin D3’s main catabolite 24,25-dihydroxyvitamin D3 concentration in serum and follicular fluid: An ovarian ageing explanation. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ESHRE 2019
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Garrido N
O-223: Finding the best sperm
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Sakkas D Atkinson L Borini A Bosch E Bryce C Cattoli M Finet de Bantel A French B Gaitonde S Gerris J Granger S Grzegorczk-Martin V Howles C Somers S Alper M Can "patient-friendly" salivary hormone measurements replace serum monitoring of IVF Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018