Immunology
The association between the immune system and reproductive function has long been an attractive target in research. Unfortunately, much of the early work has been misguided leading to premature implementation of therapeutic measures. Thus, a return to the drawing board approach is necessary.
There is renewed interest in foundational research to further our understanding of the immune interaction between the embryo and the endometrium. These studies will likely give new life to research in reproductive immunology. Building upon this foundational work will allow for more artful manipulation of the immune system to improve reproductive outcomes.
Investigators working in this area
Publications from this area
- Macrophages display proinflammatory phenotypes in the eutopic endometrium of women with endometriosis with relevance to an infectious etiology of the disease.
Vallvé-Juanico J Santamaría X Vo KC Houshdaran S Giudice LC
Fertil Steril. 2019 Dec;112(6):1118-1128. doi: 10.1016/j.fertnstert.2019.08.060. - Predicting suboptimal oocyte yield following GnRH agonist trigger by measuring serum LH at the start of ovarian stimulation.
Popovic-Todorovic B Santos-Ribeiro S Drakopoulos P De Vos M Racca A Mackens S Thorrez Y Verheyen G Tournaye H Quintero L Blockeel C
Hum Reprod. 2019 Sep 27. pii: dez132. doi: 10.1093/humrep/dez132. [Epub ahead of print] - The vaginal microbiome in uterine transplantation.
Jones BP Soso S L'Heveder A Bracewell-Milnes T Thum MY Diaz-Garcia C Maclntyre DA Quiroga I Ghaem-Maghami S Testa G Johannesson L Bennett PR Yazbek J Smith JR
BJOG. 2019 Aug 8. doi: 10.1111/1471-0528.15881. [Epub ahead of print] Review. - Ovarian Stimulation (OS) Does Not Influence the Uterine Immune Environment in Healthy Infertile Women
D. Alecsandru A. Pacheco A. Guerrero-Mayo A. Fabris P. Aparicio A. Barrio Pellicer A Juan A García-Velasco
Reproductive BioMedicine Online, In press, journal pre-proof, Available online 22 August 2019 - Understanding the role of killer cell immunoglobulin-like receptors in pregnancy complications.
Díaz-Peña R de Los Santos MJ Lucia A Castro-Santos P
J Assist Reprod Genet. 2019 Mar 7. doi: 10.1007/s10815-019-01426-9. [Epub ahead of print] Review. - Pancreatic autoimmunity: An unknown etiology on patients with assisted reproductive techniques (ART)-recurrent reproductive failure.
Alecsandru D Barrio A Andia V Cruz E Aparicio P Serna J Cruz M Pellicer A García-Velasco JA
PLoS One, 13(10):NA-NA, 2018. - Endometrioma, fertility, and assisted reproductive treatments: connecting the dots.
Cecchino GN García-Velasco JA
Curr Opin Obstet Gynecol, 30(4):223-228, 2018. - Evaluation of PAI-1 in endometriosis using a homologous immunocompetent mouse model.
A Buigues Ferrero H Martínez J Pellicer N Pellicer A Gómez R
Biol Reprod, 99(2):326-335, 2018. - The implications of male human papilloma virus infection in couples seeking assisted reproduction technologies.
Gamze Sinem Çaglar Garrido N
J Turk Ger Gynecol Assoc, 15;19(1):48-52. doi: 10.4274/jtgga.2017.0031, 2018. - The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology.
Moreno I Cicinelli E Garcia-Grau I Gonzalez M Bau D Vilella F Ziegler D Resta L Valbuena D Simón C
Am J Obstet Gynecol, 218(6):602-602, 2018.
Read more
Presentations from this area
- Ángel Martin Vidal C Rodrigo L Mercader A Rubio C Giles J Remohí J De los Santos MJ P-310 Impact of different degrees of genetic mosaicism in the kinetic profile of the human embryo Presented at 75th American Society of Reproductive Medicine Scientific Congress
ASRM 2019
- Marin D Tao X Sun L Scott RT O-255 UNRAVELLING THE IMMUNOGENETICS OF PREGNANCY: PARENTAL HLA-C ALLOTYPES ARE PREDICTIVE OF PREGNANCY LOSS AFTER SINGLE EUPLOID EMBRYO TRANSFERS Presented at 75th American Society of Reproductive Medicine Scientific Congress
- Kim G Marugappan G Lathi RB Kort JD Hanson BM Tiegs AW Osman EK Neal SA Scott RT P-745 PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A) REDUCES MISCARRIAGE AND IMPROVES LIVE BIRTH RATES IN RECURRENT PREGNANCY LOSS PATIENTS Presented at 75th American Society of Reproductive Medicine Scientific Congress
- Cakiroglu Y Saltik A Yuceturk A Karaosmanoglu O Tayyar A Scott RT Tiras B Seli E O-171 EFFECTS OF INTRAOVARIAN INJECTION OF AUTOLOGOUS PLATELET RICH PLASMA ON OVARIAN RESERVE AND IVF OUTCOMES IN WOMEN WITH PREMATURE OVARIAN INSUFFICIENCY Presented at 75th American Society of Reproductive Medicine Scientific Congress
- Alecsandru D Guerrero A Aparicio P Romero M Barrio A Pellicer A Garcia Velasco JA O-130: Treatment strategies to increase the live birth rate in patients with KIR-HLA-C mismatch: a retrospective cohort study Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology
ESHRE 2019
- Alecsandru D Pacheco A Fabris A Barrio A Aparicio P García-Velasco J Ovarian stimulation doesn’t influence the uterine immune environment in healthy infertile women Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ASRM 2018
- Alecsandru D Iglesias C Pacheco A Barrio A Garrido N Garcia Velasco J HLA-C haplotypes distribution among gametes donors in our population Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
- Alecsandru D Pacheco A Garrido N Barrio A Aparicio P Pellicer A Garcia Velasco J Live birth rate after oocyte donation is influenced by donor HLA-C: one step beyond conventional markers of success Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017