Immunology
The association between the immune system and reproductive function has long been an attractive target in research. Unfortunately, much of the early work has been misguided leading to premature implementation of therapeutic measures. Thus, a return to the drawing board approach is necessary.
There is renewed interest in foundational research to further our understanding of the immune interaction between the embryo and the endometrium. These studies will likely give new life to research in reproductive immunology. Building upon this foundational work will allow for more artful manipulation of the immune system to improve reproductive outcomes.
Investigators working in this area
Publications from this area
- Pancreatic autoimmunity: An unknown etiology on patients with assisted reproductive techniques (ART)-recurrent reproductive failure.
Alecsandru D Barrio A Andia V Cruz E Aparicio P Serna J Cruz M Pellicer A García-Velasco JA
PLoS One, 13(10):NA-NA, 2018.
- Endometrioma, fertility, and assisted reproductive treatments: connecting the dots.
Cecchino GN García-Velasco JA
Curr Opin Obstet Gynecol, 30(4):223-228, 2018.
- Evaluation of PAI-1 in endometriosis using a homologous immunocompetent mouse model.
A Buigues Ferrero H Martínez J Pellicer N Pellicer A Gómez R
Biol Reprod, 99(2):326-335, 2018.
- The implications of male human papilloma virus infection in couples seeking assisted reproduction technologies.
Gamze Sinem Çaglar Garrido N
J Turk Ger Gynecol Assoc, 15;19(1):48-52. doi: 10.4274/jtgga.2017.0031, 2018.
- The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology.
Moreno I Cicinelli E Garcia-Grau I Gonzalez M Bau D Vilella F Ziegler D Resta L Valbuena D Simón C
Am J Obstet Gynecol, 218(6):602-602, 2018.
- Natural killer cells in reproduction: helpful, harmful, or misunderstood?
Morin SJ Franasiak JM
Consider This: Fertility and Sterility Dialog. May 2017.
- Mu opioid receptor in the human endometrium: dynamics of its expression and localization during the menstrual cycle.
Totorikaguena L Olabarrieta E Matorras R Alonso E Agirregoitia E Agirregoitia N
Fertil Steril, 107:1070-1077, 2017.
- A novel homologous model for noninvasive monitoring of endometriosis progression†.
Ferrero H Buigues A Martinez J Simón C Pellicer A Gomez R
Biol Reprod. 2017 Feb 1;96(2):302-312. doi: 10.1095/biolreprod.116.140756.
- Why natural killer cells are not enough: a further understanding of killer immunoglobulin-like receptor and human leukocyte antigen.
Alecsandru D García-Velasco JA
Fertil Steril. 2017 Jun;107(6):1273-1278. doi: 10.1016/j.fertnstert.2017.04.018. Epub 2017 May 10. Review.
- Contribution of immunology to implantation failure of euploid embryos.
Franasiak JM Scott RT
Fertil Steril. 2017 Jun;107(6):1279-1283. doi: 10.1016/j.fertnstert.2017.04.019. Epub 2017 May 10.
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Presentations from this area
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Alecsandru D Pacheco A Fabris A Barrio A Aparicio P García-Velasco J Ovarian stimulation doesn’t influence the uterine immune environment in healthy infertile women Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ASRM 2018
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Alecsandru D Iglesias C Pacheco A Barrio A Garrido N Garcia Velasco J HLA-C haplotypes distribution among gametes donors in our population Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
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Alecsandru D Pacheco A Garrido N Barrio A Aparicio P Pellicer A Garcia Velasco J Live birth rate after oocyte donation is influenced by donor HLA-C: one step beyond conventional markers of success Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017