Cryobiology
Advances in techniques for freezing gametes (sperm, eggs) and embryos has been a boon for the field of reproductive medicine.
Refined vitrification methods for embryos produce outstanding survival rates and have helped to improve pregnancy rates by allowing clinics to optimize embryo-endometrial synchrony in frozen embryo transfer cycles and to facilitate preimplantation genetic testing. A long standing research program at IVI RMA Global examining the safety of modern egg freezing protocols have also helped push this procedure from the realm of the experimental to every day practice in many clinics.
Furthermore, researchers have performed ovarian tissue cryopreservation proceduress, whereby the ovary is removed from the body prior to gonadotoxic medical therapy, such as chemotherapy, frozen, and then replaced after completion of treatment.
This cutting edge research has produced live born babies and may provide hope for patients who previously had few options after a devastating diagnosis, such as cancer.
Investigators working in this area
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Publications from this area
- Effect of oocyte morphology on post-warming survival and embryo development in vitrified autologous oocytes
Aila Coello Eva Sanchez Begoña Vallejo Marcos Meseguer José Remmohí Ana Cobo
Reprod Biomed Online. 2019 Jan 8. pii: S1472-6483(19)30007-0. doi: 10.1016/j.rbmo.2018.11.028. [Epub ahead of print]
- Pre-clinical validation of a closed surface system (Cryotop SC) for the vitrification of oocytes and embryos in the mouse model.
Castello D Cobo A Vanrell I Garcia M Calderon G Remohí J Mestres E Costa-Borges N
Cryobiology, 81:107-116, 2018.
- Vitrification of human oocytes.
Coello A Pellicer A Cobo A
Minerva Ginecol, 70(4):415-423, 2018.
- Oocyte vitrification versus ovarian cortex transplantation in fertility preservation for adult women undergoing gonadotoxic treatments: a prospective cohort study.
Diaz-Garcia C Domingo J García-Velasco JA Herraiz S Mirabet V Iniesta I Cobo A Remohí J Pellicer A
Fertil Steril, 109(3):478-485, 2018.
- The impact of vitrification in artificial reproductive technology programmes
Manish Banker Kotdawala A Reena Gupta
European Medical Journal, Nov 2017
- The impact of elevated progesterone at the initiation of an artificially prepared frozen embryo transfer cycle: a case series.
Drakopoulos P Mat C Polyzos NP Santos-Ribeiro S van de Vijver A Van Landuyt L Tournaye H Blockeel C
Curr Pharm Biotechnol. 2017;18(8):619-21
- Vitrified-warmed blastocyst transfer on the 5th or 7th day of progesterone supplementation in an artificial cycle: a randomised controlled trial
Van de Vijver A Drakopoulos P Polyzos NP Van Landuyt L Mackens S Santos-Ribeiro S Vloeberghs V Tournaye H Blockeel C
Gynecol Endocrinol 2017; 26:1-4
- Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance.
Rienzi L Cracia C Maggiulli R LaBarbera AR Kaser DJ Ubaldi FM Vanderpoel S
Hum Reprod Update, 23:139-155. 2017.
- The slow growing embryo and premature progesterone elevation: compounding factors for embryo-endometrial asynchrony.
Healy MW Yamasaki M Patounakis G Richter KS Devin K DeCherney AH Hill MJ
Hum Reprod, 32:362-7. 2017.
- Should we forget about embryos till day 5?
Bronet F Agudo Garcillán D
Curr Opin Obstet Gynecol 2017, 29:107-111 DOI:10.1097/GCO.0000000000000355
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Presentations from this area
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Albert C Del Gallego R Alegre A Larreategui Z Marcos J Aparicio Ruiz B Meseguer M O-109 The effect of high humidity on embryo culture media oxidation Presented at 75th American Society of Reproductive Medicine Scientific Congress
ASRM 2019
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Coello A De los Santos MJ Nohales Corcoles M Meseguer M Remohí J Cobo A
P-107 Impact of fresh blastocyst parameters on survival and implantation in vitrified blastocyst cycles: analysis of 11936 warmed blastocysts.
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Osman EK Neal SA Tiegs AW Hanson BM Kim G Franasiak JM Scott RT
P-319 RATES OF EMBRYONIC MOSAICISM ARE CONSISTENT AMONGST EMBRYOLOGISTS PERFORMING OR LOADING TROPHECTODERM BIOPSIES FOR PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Tao X Zhan Y Scott KL Scott RT Seli E
P-55 COMPARATIVE ANALYSIS OF DNA METHYLATION IN EUPLOID AND ANEUPLOID HUMAN EMBRYOS USING REDUCED REPRESENTATION BISULFITE SEQUENCING
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Melado Vidales L Arnanz A Bayram A Nkuhlu A Ibrahim E Navarro A Lawrenz B Fatemi H P-661: Anti-Müllerian Hormone (AMH) is an independent marker for oocyte survival post vitrification. Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology
ESHRE 2019
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Cobo A García Velasco JA Domingo J Nohales M Coello A Gamiz P Pellicer A Remohí J
P-749: Obstertric and perinatal outcome of babies born after Elective Fertility Preservation (EFP).
Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology
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Coello A De los Santos MJ Meseguer M Nohales M Remohí J Galan A Cobo A
P-181: Day of vitrification, blastocyst developmental stage and trophectoderm quality are strongly associated with survival and implantation in vitrified blastocyst cycles: analysis of 12064 warmed bl
Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology
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Coello A Sanchez E Campos P Vallejo B Meseguer M Cobo A Oocyte dysmorphisms are not associated with post warming survival, fertilization and embryo development in own oocytes vitrification cycles Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2017
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Colombo S Franasiak JM Kaser DJ Molinaro T Bergh PA
Significance of endometrial lining decrease after progesterone start in synthetic frozen embryo transfer (FET) cycles
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Cerrillo M Cruz M Ferrando R García Velasco JA Freeze-all strategy in endometriosis patients - a new indication? Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017
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Díaz-García C Domingo J Herraiz S Iniesta I Cobo A Garcia-Belda A Rubio JM Garcia-Velasco JA Pellicer A
O-083 Fertility preservation by oocyte vitrification or ovarian cortex cryopreservation. A prospective cohort study
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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García Camuñas N Vázquez S Pellicer N Jesica S Garcia Belda A Andres M Herraiz S Pellicer A Díaz García C
Fertility preservation. Anatomopathological analysis of ovarian cortex metastasis in a large cohort of patient undergoing fertility preservation through ovarian cortex cryopreservation
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology