Cryobiology
Advances in techniques for freezing gametes (sperm, eggs) and embryos has been a boon for the field of reproductive medicine.
Refined vitrification methods for embryos produce outstanding survival rates and have helped to improve pregnancy rates by allowing clinics to optimize embryo-endometrial synchrony in frozen embryo transfer cycles and to facilitate preimplantation genetic testing. A long standing research program at IVI RMA Global examining the safety of modern egg freezing protocols have also helped push this procedure from the realm of the experimental to every day practice in many clinics.
Furthermore, researchers have performed ovarian tissue cryopreservation proceduress, whereby the ovary is removed from the body prior to gonadotoxic medical therapy, such as chemotherapy, frozen, and then replaced after completion of treatment.
This cutting edge research has produced live born babies and may provide hope for patients who previously had few options after a devastating diagnosis, such as cancer.
Investigators working in this area
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Publications from this area
- Anti-Müllerian hormone is an independent marker for oocyte survival after vitrification.
Melado L Arnanz A Bayram A Elkhatib I De Munck N Navarro AT Coughlan C Lawrenz B Fatemi HM
Reprod Biomed Online. 2020 Jul;41(1):119-127. doi: 10.1016/j.rbmo.2020.03.014. Epub 2020 Apr 28.
- Should we still perform fresh embryo transfers in ART?
Blockeel C Campbell A Coticchio G Esler J García-Velasco JA Santulli P Pinborg A
Hum Reprod. 2019 Dec 5. pii: dez233. doi: 10.1093/humrep/dez233. [Epub ahead of print]
- A follow-up survey on the reproductive intentions and experiences of women undergoing planned oocyte cryopreservation
A. Wafi J. Nekkebroeck C. Blockeel N. De Munch Tournaye H De Vos A
Reproductive BioMedicine Online, in press, journal pre-proof, available online 29 November 2019
- Effect of oocyte morphology on post-warming survival and embryo development in vitrified autologous oocytes
Aila Coello Eva Sanchez Begoña Vallejo Marcos Meseguer José Remmohí Ana Cobo
Reprod Biomed Online. 2019 Jan 8. pii: S1472-6483(19)30007-0. doi: 10.1016/j.rbmo.2018.11.028. [Epub ahead of print]
- To delay or not frozen embryo transfer in freeze-all cycles?
Drakopoulos P Santos-Ribeiro S Mackens S Racca AL Blockeel C Tournaye H Makrigiannakis A
Ann Transl Med. 2020 Jul;8(13):812. doi: 10.21037/atm.2020.03.209.
- Ovarian tissue cryopreservation is standard of care in prepubertal patients, but does it have to be?
Hanson BM Franasiak JM
Fertil Steril. 2020 Aug;114(2):277-278. doi: 10.1016/j.fertnstert.2020.06.028.
- COVID-19 and assisted reproductive technology services: repercussions for patients and proposal for individualized clinical management.
Alviggi C Esteves SC Orvieto R Conforti A La Marca A Fischer R Andersen CY Bühler K Sunkara SK Polyzos NP Strina I Carbone L Bento FC Galliano D Yarali H Vuong LN Grynberg M Drakopoulos P Xavier P Llacer J Neuspiller F Horton MRoque M Papanikolaou E Banker M Dahan MH Foong S Tournaye H Blockeel C Vaiarelli A Humaidan P Ubaldi FM POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) group
Reprod Biol Endocrinol. 2020 May 13;18(1):45. doi: 10.1186/s12958-020-00605-z.
- The freeze-all strategy versus agonist triggering with low-dose hCG for luteal phase support in IVF/ICSI for high responders: a randomized controlled trial.
Santos-Ribeiro S Mackens S Popovic-Todorovic B Racca A Polyzos NP Van Landuyt L Drakopoulos P de Vos M Tournaye H Blockeel C
Hum Reprod. 2020 Sep 23:deaa226. doi: 10.1093/humrep/deaa226. Online ahead of print.
- Anti-Müllerian hormone is an independent marker for oocyte survival after vitrification.
Melado L Arnanz A Bayram A Elkhatib I De Munck N Navarro AT Coughlan C Lawrenz B Fatemi HM
Reprod Biomed Online. 2020 Jul;41(1):119-127. doi: 10.1016/j.rbmo.2020.03.014. Epub 2020 Apr 28.
- Pre-clinical validation of a closed surface system (Cryotop SC) for the vitrification of oocytes and embryos in the mouse model.
Castello D Cobo A Vanrell I Garcia M Calderon G Remohí J Mestres E Costa-Borges N
Cryobiology, 81:107-116, 2018.
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Presentations from this area
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Rafael F Mollá Robles G Alfredo Muñoz Navarro A Garrido N Garcia-Velasco JA Bosch E Sofia Gouveia Nunes Reis Soares S Santos-Ribeiro S O-264 SIMILAR PERINATAL OUTCOMES IN CHILDREN BORN AFTER FRESH OR FROZEN EMBRYO TRANSFER USING DONATED OOCYTES Presented at 76th American Society of Reproductive Medicine Scientific Congress
ASRM2020
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Vidal C Giles J Mollá Robles G De los Santos MJ Remohí J Cobo A
P-542 LESSONS LEARNED FROM A 10 YEARS CRYOEMBRYO VITRIFICATION PROGRAM: THE AGE OF THE OOCYTE MATTERS.
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Gill P Kim JG Bergh PA Scott RT
P-349 ULTRASOUND IMAGING PREDICTS ENDOMETRIAL RECEPTIVITY – A DECREASE IN ENDOMETRIAL THICKNESS (COMPACTION) PRIOR TO EMBRYO TRANSFER IS ASSOCIATED WITH AN INCREASE IN CLINICAL PREGNANCY RATE IN SYNTHETIC FROZEN EUPLOID IVF CYCLES
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Osman EK Esbert M Hanson BM Ayesha D. Winslow Seli E Scott RT
O-92 EMBRYO VITRIFICATION IN SUPER COOLED SLUSH NITROGEN RESULTS IN SUPERIOR POST-THAW SURVIVAL COMPARED TO CONVENTIONAL LIQUID NITROGEN: A BLINDED, RANDOMIZED CONTROLLED TRIAL
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Cruz M Ruiz ME
P-1011 HP-HMG IN MONOTHERAPY IMPROVES CLINICAL OUTCOMES IN YOUNG WOMEN
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Soriano MG Martínez J Lopez R Herraiz S Díaz-García C O-038 A new strategy to assess safety of controlled ovarian stimulation protocols for oocyte vitrification as a fertility preservation technique in breast cancer patients. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2020
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Quintana Berto R Santolaria Baig Garcia Camuñas N Subirá Nadal J Polo Sanchez P Rubio Rubio JM
Ovarian stimulation for fertility preservation in young women: is there a right time to start?
Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
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Santolaria Baig A Quintana Berto Garcia Camuñas N Subirá Nadal J Polo Sánchez P Rubio Rubio JM
Fertility preservation in adolescent women: should we expect the same response?
Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
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Siffain J Racca A Drakopoulos P Popovic-Todorovic B Roelens C Mackens S Tournaye H De Vos M Fatemi H Blockeel C
Variation in luteinizing hormone levels in artificially prepared frozen-thawed embryo transfer cycles: impact on live birth rates
Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
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El Damen A Elkhatib I Bayram A Arnanz A Samir S De Munk N Lawrenz B Fatemi H P-119 IS THERE A RELATIONSHIP BETWEEN MITOCHONDRIAL DNA CONTENT AND ABORTION RATE IN PATIENTS UNDERGOING SINGLE EUPLOID FROZEN EMBRYO TRANSFER? Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2019
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Hanson BM Kim G Osman EK Tiegs AW Scott RT Neal SA Franasiak JM
P-90 INCREASED PATERNAL AGE IS ASSOCIATED WITH DECREASED BLASTULATION AND EUPLOID RATES BUT NOT PREGNANCY OUTCOMES IN THE SETTING OF A EUPLOID SINGLE EMBRYO TRANSFER
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Kim G Hanson BM Reig A Neal SA Tiegs AW Osman EK Bergh PA Seli E Scott RT
P-481 THE IMPACT OF IVF ON NEONATAL BIRTHWEIGHT FROM 2000 TO 2017: A DRAMATIC REDUCTION OF LOW BIRTHWEIGHT INFANTS
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Esencan Jiang Z Wang T Zhang M Bener MB Scott RT Impaired mitochondrial stress response in cumulus cells is associated with increased apoptosis and accelerated follicular depletion Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2018
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Insua M Escriba M Vendrell X Peinado V Viloria T
Segmental aneuploidy in blastocysts: when the chromosomes break
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Azkargorta M Escobes I Lloro I Osinalde N Corral B Exposito A Prieto B Elortza F Matorras R Differential proteomic analysis of endometrial fluid suggets increased inflammation and extracellular matrix remodeling in non-implantative IVF cycles Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
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Morin SJ Tiegs A Jalas C Zhan Y Landis J Neal S Franasiak JM Scott RT
Higher resolution aneuploidy screening with targeted NGS may increase the pool of transferrable embryos despite inclusion of segmental and mosaic range diagnostic categories
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Cruz M Alecsandru D Garcia Velasco J Requena A
Use of granulocyte colony-stimulating factor during an assisted reproductive treatment does not increase the risk of birth defects
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology