Male fertility
Male factor is solely responsible for fertility issues in 20% of couples and contributes to an additional 30-40%. The semen analysis has been the benchmark of male fertility assessment for many decades, however wide variability in counts, motility and morphology contribute to the enigma of determining who benefits from fertility treatments including intra-uterine insemination and in-vitro fertilization with or without intra-cytoplasmic sperm injection.
More recently, delving in the world of DNA fragmentation has fueled the search for additional sperm quality parameters. Cutting edge questions are emerging including application of microfluidics devices for sperm isolation and epigenetic determinants of sperm quality and impact on offspring.
Investigators working in this area
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Publications from this area
- Does donor sperm improve reproductive outcome after oocyte donation failure? A retrospective analysis of cumulative live birth rates per donor oocyte consumed
Cozzolino M I Hervás Rocio Rivera-Egea Pellicer A Garrido N
Reproductive BioMedicine OnlineAvailable online 16 January 2021
- Timing of spermatogonial stem cell transplantation affects the spermatogenic recovery outcome in mice.
Medrano JV Acimovic I Navarro-Gomezlechon A Noguera I Pellicer A Andrés MM Novella-Maestre E
In Vitro Cell Dev Biol Anim. 2021 Jan 8. doi: 10.1007/s11626-020-00531-9. Online ahead of print.
- Role of the sperm, oocyte, and embryo in recurrent pregnancy loss
Klimczak A Darshan P.Patel Hotaling J Scott RT
Fertility and Sterility, Volume 115, Issue 3, March 2021, Pages 533-537 ...
- Serum AMH levels are not associated with aneuploidy rates in human blastocysts
Pipari A Guillen A Cruz M Pacheco A Garcia Velasco J
Reproductive BioMedicine Online Available online 15 March 2021, In press
- (Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability
Gianzo M Urizar-Arenaza I Muñoa-Hoyos I Larreategui Z Garrido N Irazusta J Subirán N
Int. J. Mol. Sci. 2021, 22, 3215. https://doi.org/10.3390/ijms22063215
- A global approach to addressing the policy, research and social challenges of male reproductive health
Barratt CLR De Jonge CJ Anderson RA Eisenberg ML Garrido N Satu Rautakallio Hokkanen Krausz C Kimmins S OBryan MK Pace AA Tüttelmann F Veltman JA
Human Reproduction Open, Volume 2021, Issue 1, 2021, hoab009, https://doi.org/10.1093/hropen/hoab009
- Are we approaching automated assisted reproductive technology? Sperm analysis, Oocyte manipulation and insemination.
Casciani V Galliano D Franasiak JM Mariani G Meseguer M
F&S Reviews Available online 29 March 2021 In Press, Journal Pre-proof
- Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort.
Cerván-Martín M Bossini-Castillo L Rivera-Egea R Garrido N Luján S Romeu G Santos-Ribeiro S; IVIRMA Group; Lisbon Clinical Group Castilla JA Carmen Gonzalvo M Clavero A Vicente FJ Guzmán-Jiménez A Burgos M Barrionuevo FJ Jiménez R Sánchez-Curbelo J López-Rodrigo O Peraza MF Pereira-Caetano I Marques PI Carvalho F Barros ABassas L Seixas S Gonçalves J Larriba S Lopes AM Carmona FD Palomino-Morales RJ.
Andrology. 2021 Mar 30. doi: 10.1111/andr.13009. Online ahead of print.
- Histologic Analysis of Testes from Prepubertal Patients Treated with Chemotherapy Associates Impaired Germ Cell Counts with Cumulative Doses of Cyclophosphamide, Ifosfamide, Cytarabine, and Asparaginase.
Medrano JV Hervás D Vilanova-Pérez T Navarro-Gomezlechon A Goossens E Pellicer A Andrés MM Novella-Maestre E
Reprod Sci. 2020 Nov 4. doi: 10.1007/s43032-020-00357-6. Online ahead of print.
- Healthy baby born after ICSI with ejaculated immotile spermatozoa from a male Kartagener syndrome using Magnetic-Activated Cell Sorting (MACS) as a compliment of sperm preparation technique: A case report
Losada C Pacheco A
Medicina Reproductiva y Embriología ClínicaIn press, corrected proofAvailable online 20 November 2020
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Presentations from this area
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Romany L Viloria T Aparicio-Ruiz B Diana Beltrán Remohi JA Meseguer M P-81 MACS TECHNOLOGY APPLIED FOR SPERM SELECTION IMPROVES BLASTOCYST QUALITY; A CONTINIOUS EMBRYO MONITORING STUDY. Presented at 76th American Society of Reproductive Medicine Scientific Congress
ASRM2020
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Hervas I Garrido N Valls L Rivera-Egea R Gil Julia M Martinez-Jabaloyas JM
P-531 OPTIMAL REPRODUCTIVE OUTCOMES OBTAINED FROM VASECTOMIZED MALES UNDERGOING TESE (TESTICULAR SPERM EXTRACTION) AND INTRACYTOPLASMIC SPERM INJECTION WITH OWN OR DONATED OOCYTES.
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Garrido N Valls L Hervas I Rivera-Egea R Gil Julia M Martinez-Jabaloyas JM
P-687 TIME SINCE VASECTOMY, BUT NEITHER SMOKING NOR BODY MASS INDEX (BMI) INFLUENCE IN VASECTOMIZED MEN REPRODUCTIVE OUTCOMES UNDERGOING TESTICULAR SPERM EXTRACTION WITH INTRACYTOPLASMIC SPERM INJECTION (TESE-ICSI).
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Hervas I Valls L Garrido N Rivera-Egea R Gil Julia M Martinez-Jabaloyas JM
P-694 NEWBORN RATE IS NOT IMPAIRED BY TIME FROM VASECTOMY, SMOKING AND BODY MASS INDEX (BMI) IN COUPLES WITH VASECTOMIZED MALE REQUIRING AN ASSISTED REPRODUCTIVE TECHNIQUE USING OOCYTE DONATION (OD).
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Valls L Hervas I Martinez-Jabaloyas JM Rivera-Egea R Gil Julia M Garrido N
P-668 REPRODUCTIVE EFFECTS OF DIABETES, DYSLIPIDEMIA AND HYPERTENSION IN TESTICULAR SPERM EXTRACTION (TESE) WITH INTRACYTOPLASMIC SPERM INJECTION (ICSI) FROM VASECTOMIZED MALES.
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Hervas I Garrido N Rivera-Egea R Gonzalez-Ravina C Amoros D Quintana F Gil Julia M Pacheco A
O-105 ACCURATE MEASUREMENT OF SPERM DNA FRAGMENTATION EFFECT ON REPRODUCTIVE OUTCOMES BY CUMULATIVE LIVEBIRTH RATES (CLBR) PER EMBRYO TRANSFERRED AND OOCYTE UTILIZED REVEALS ITS LACK OF RELEVANCE IN OOCYTE DONATION FOR UNSELECTED MALES.
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Hervas I Garrido N Rivera-Egea R Gonzalez-Ravina C Amoros D Quintana F Gil Julia M Pacheco A
P-14 REALISTIC MEASUREMENT OF THE EFFECT OF SPERM DNA FRAGMENTATION ON REPRODUCTIVE OUTCOMES BY CUMULATIVE LIVEBIRTH RATES (CLBR) PER EMBRYO REPLACED AND OOCYTE EMPLOYED REVEALS ITS LACK OF RELEVANCE IN UNSELECTED MALES USING OWN OOCYTES.
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Gil Julia M Quintana F Amoros D Pacheco A Gonzalez-Ravina C Rivera-Egea R Hervas I Garrido N
P-117 CLINICALLY IRRELEVANT EFFECT OF NON-APOPTOTIC SPERM SELECTION BY MAGNETIC ACTIVATED CELL SORTING BEFORE INTRACYTOPLASMIC SPERM INJECTION IN DONATED OOCYTES, AS MEASURED BY CUMULATIVE LIVE BIRTH RATES.
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Gil Julia M Quintana F Amoros D Pacheco A Gonzalez-Ravina C Rivera-Egea R Hervas I Garrido N
P-16 SEPARATION OF NON-APOPTOTIC SPERM VIA MAGNETIC ACTIVATED CELL SORTING BEFORE INTRACYTOPLASMIC SPERM INJECTION IN AUTOLOGOUS OOCYTES INCREASED CUMULATIVE LIVE BIRTH RATES WITH LIMITED CLINICAL IMPACT.
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Hanson BM Cheng PJ Kim JG Osman EK Tiegs AW Herlihy NS Klimczak AM Scott RT Hotaling J
P-659 THE RELATIONSHIP BETWEEN MEDICAL TREATMENT MODALITIES FOR MALE HYPOGONADISM AND ICSI OUTCOMES
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Rodriguez Valderrama F Palomino MC Pla Victori J Requena A Chromosomal abnormalities in males, but not chromosomal polymorphisms, affect the preterm delivery rate in ICSI+PGT cycles Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2020
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Fragouli Babariya Cutts G Lozoya Garcia V Fernandez Marcos E Parnell L Symon-Allen A Bronet F Florensa M Prados N Mercader A Garrido N Wells D
O-295 The influence of poor semen parameters on embryonic chromosome segregation
Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
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Drakopoulos P Di Guardo F Blockeel C De Vos M Anckaert E Verheyen G Santos-Ribeiro S Racca S Boudry L Mackens Tournaye H Vloebergs V
Low male testosterone results in a substantial decrease of fresh live birth rates in couples with non-male factor infertility undergoing IVF
Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
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Garrido N
Consequences, uses and abuses of sperm DNA Damage
Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
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Cozzolino M Hervás I Rivera-Egea R Pellicer A Garrido N
Impact of sperm quality to achieve pregnancies in oocyte donation cycles
Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
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Hotaling J
Sexual transmission of Covid19 and male fertility
Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
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Garrido N
Advanced sperm testing and selection
Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
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Albert C Del Gallego R Alegre A Larreategui Z Marcos J Aparicio Ruiz B Meseguer M O-109 The effect of high humidity on embryo culture media oxidation Presented at 75th American Society of Reproductive Medicine Scientific Congress
ASRM 2019
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Hanson BM Kim G Osman EK Tiegs AW Neal SA Werner MD Scott RT
P-228 THE IMPACT OF OVARIAN RESPONSE ON CLINICAL PREGNANCY AND DELIVERY RATES IN AN OOCYTE DONOR POPULATION
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Hariharan Meseguer M Toschi M Rocha CJ Zaninovic N Malmsten J Zhan Y Hickman C
O-91 ARTIFICIAL INTELLIGENCE ASSESSMENT OF TIME-LAPSE IMAGES CAN PREDICT WITH 77% ACCURACY WHETHER A HUMAN EMBRYO CAPABLE OF ACHIEVING A PREGNANCY WILL MISCARRY
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Yang M Tao X Zhao T Scott RT Seli E
P-390 ANALYSIS OF ACCESSIBLE CHROMATIN LANDSCAPE IN THE INNER CELL MASS AND TROPHECTODERM OF HUMAN BLASTOCYSTS USING ATAC-SEQ
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Bosch E Aasted H Klein BM Arce JC
P-182 A randomized, doble-blind, placebo-controlled, multi-center, phase 2 trial to investigate the effect of barusiban on implantation in IVF/ICSI patients
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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D. Castello Salom Del Gallego R Bori L Hervas I Alegre L Cnaani T Shnizer S Meseguer M P-232: High levels of Follicular fluid oxidative stress are present in younger patients and fertile donors Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ESHRE 2019
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Escrich L Soler N González Picazo A Buendía P Escribá MJ De los Santos MJ
P-276: Effect of different commercial media on spontaneous in vitro maturation and kinetics of germinal-vesicle human oocytes
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Georgiou E Melo P Baker P Sallam H Arici A Garcia-Velasco JA Abou-Setta A Becker C Granne I
O-208: Long-term gonadotrophin-releasing hormone agonist (GnRHa) therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with endometriosis: a Cochrane systematic review and meta-analysis
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Schutyser V Santos-Ribeiro S De Vos M Boudry L Tournaye H Blockeel C
P-294: Should we care about polyps detected during the follicular phase of intrauterine insemination treatments?
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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García-Acero P Alemán A Devesa-Peiro A Diaz-Gimeno P Drug-Target Model for Discovering and Personalizing Endometriosis Therapies. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2019
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Gonzalez-Martin R Quiñonero A Pérez-Debent S Salsano S Domínguez F
Endometrial Stromal Cells Acutely Exposed to DEHP Do Not Recapitulate Alterations Observed in Endometriosis_
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Scott RT Sun L Landis J Zhan Y Marin D Tao X Seli E
Mitochondrial DNA Copy Number in Trophectoderm is Not a Predictive Biomarker for Human Embryo Viability
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Lara-Molina EE Franasiak JM Devesa-Peiro A Martin M Florensa M Lopez M Díaz-Gimeno P Pellicer A 24,25(oh)2d3: a novel accurate indicator of ovarian vitamin d status in women at reproductive age Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2018
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Fernandez-Sanchez M Visnova H Yuzpe A Klein BM Mannaerts B Arce JC
Individualization of the starting dose of gonadotropin reduces the overall ohss risk and the need of preventive cumulative data over three
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Tao X Zhan Y Scott KL Scott RT Seli E
Dna methylation is associated with ploidy status and patient age in human embryos
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Parker PB Morin SJ Neal SA Tiegs W Werner MD
Inner cell mass and trophectoderm morphology impact the likelihood of achieving sustained implantation among expanded, euploid blastocysts
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Selles E Hernandez-Vargas P Garrido N Vilella F Perez-Cano I Muñoz M
Looking for molecular biomarkers of cryodamage in donors semen
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Bosch E Howles C
No difference in clinical outcomes using follitropin alfa (biosimilar) compared to follitropin alfa or follitropin beta for controlled ovarian stimulation (cos) in oocyte donation-recipient cycles
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Alecsandru D Iglesias C Pacheco A Barrio A Garrido N Garcia Velasco J HLA-C haplotypes distribution among gametes donors in our population Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ESHRE 2018
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Herrer Saura R Sciorio R Esbert M Pickering S Thong J Meseguer M
Blastocysts collapse as an embryo marker of low implantation potential a Time-Lapse study
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Steyn F Wilson J Pringle F Denton J Bagness C Miller H Wedden Y Denga A Best K Mutch J
Fertility nursing education and career progression framework
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Meseguer M Zaninovic N Nogueira F Nogueira O Oliana T Wilkinson L
Using Artificial Intelligence (AI) and Time-Lapse to improve human blastocyst morphology evaluation
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Labarta E Herraiz S De Los Santos MJ Marzal A Jose Escribá M Buigues A Pellicer A
Autologous stem cell ovarian transplant to improve ovarian response and reproductive outcomes in poor responder patients
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Beltran D Vásquez V De Los Santos MJ Do the environmental pollutants affect the mitochondrial content of human embryos? Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2017