Male fertility
Male factor is solely responsible for fertility issues in 20% of couples and contributes to an additional 30-40%. The semen analysis has been the benchmark of male fertility assessment for many decades, however wide variability in counts, motility and morphology contribute to the enigma of determining who benefits from fertility treatments including intra-uterine insemination and in-vitro fertilization with or without intra-cytoplasmic sperm injection.
More recently, delving in the world of DNA fragmentation has fueled the search for additional sperm quality parameters. Cutting edge questions are emerging including application of microfluidics devices for sperm isolation and epigenetic determinants of sperm quality and impact on offspring.
Investigators working in this area
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Publications from this area
- Tachykinins and Kisspeptins in the Regulation of Human Male Fertility.
Blasco V Pinto FM González-Ravina C Santamaría-López E Candenas L Fernández-Sánchez M
J Clin Med. 2019 Dec 31;9(1). pii: E113. doi: 10.3390/jcm9010113. Review. - Sperm DNA fragmentation on the day of fertilization is not associated with embryologic or clinical outcomes after IVF/ICSI.
Green KA Patounakis G Dougherty MP Werner MD Scott RT Franasiak JM
J Assist Reprod Genet. 2019 Nov 21. doi: 10.1007/s10815-019-01632-5. [Epub ahead of print] - Effects of lifestyle and certain toxic compounds on the male fertillity
María Jesús Sancho-Velasco Marga Esbert
Medicina Reproductiva y Embriología Clínica, in press, corrected proof, Available online 16 November 2019 - Another step forward toward the identification of sperm function biomarkers with a novel approach evaluating microRNA related pairs.
Garrido N
Fertil Steril. 2019 Nov;112(5):806-807. doi: 10.1016/j.fertnstert.2019.07.1348. No abstract available. - Donor IUI is equally effective for heterosexual couples, single women and lesbians, but autologous IUI does worse.
Soares SR Cruz M Vergara V Requena A García-Velasco JA
Hum Reprod. 2019 Nov 6. pii: dez179. doi: 10.1093/humrep/dez179. [Epub ahead of print] - The seminal microbiome in health and disease.
Altmae S Franasiak JM Mandar R
Nat Rev Urol. 2019 Nov 15. doi: 10.1038/s41585-019-0250-y. [Epub ahead of print] Review. - AUTHOR REPLY.
Tiegs AW
Urology. 2019 Oct;132:116. doi: 10.1016/j.urology.2019.06.040. No abstract available. - Correction to: ICSI does not offer any benefit over conventional IVF across different ovarian response categories in non-male factor infertility: a European multicenter analysis.
Drakopoulos P Garcia-Velasco JA Bosch E Blockeel C De Vos M Santos-Ribeiro S Makrigiannakis A Tournaye H Polyzos NP
J Assist Reprod Genet. 2019 Oct;36(10):2077-2078. doi: 10.1007/s10815-019-01586-8. - Total Motile Sperm Count Trend Over Time: Evaluation of Semen Analyses From 119,972 Men From Subfertile Couples.
Tiegs AW Landis J Garrido N Scott RT Jr Hotaling J
Urology. 2019 Jul 18. pii: S0090-4295(19)30642-9. doi: 10.1016/j.urology.2019.06.038. [Epub ahead of print] - Sperm chromosomal abnormalities and their contribution to human embryo aneuploidy.
Rodrigo L Meseguer M Mateu E Mercader A Peinado V Bori L Campos-Galindo I Milán M García-Herrero S Simón C Rubio C
Biol Reprod. 2019 Jul 18. pii: ioz125. doi: 10.1093/biolre/ioz125. [Epub ahead of print]
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Presentations from this area
- Buigues A Marchante M Martínez J Pellicer A Herraiz S Presented at the 67th Annual Meeting of the Society for Reproductive Investigation Vancouver ,Canada Aging and rejuvenation Female fertility 0-143 G-CSF Mobilized Plasma Regenerate Ovarian Stroma and Restore Ovarian Function. Presented at 75th American Society of Reproductive Medicine Scientific Congress
SRI 2020
- Castillo LM Soriano MG Martinez J Pellicer A Herraiz S Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology Copenhagen,Denmark Female fertility O-260 LH PREVENTS FOLLICULAR DAMAGE AND PRESERVES THE MEIOTIC POTENTIAL OF OOCYTES EXPOSED TO CHEMOTHERAPY AT THE PRIMORDIAL STAGE Presented at 75th American Society of Reproductive Medicine Scientific Congress
ESHRE 2020
- Soriano MG Martínez J Lopez R Herraiz S Díaz-García C Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology Copenhagen,Denmark IVF clinical Cryobiology O-038 A new strategy to assess safety of controlled ovarian stimulation protocols for oocyte vitrification as a fertility preservation technique in breast cancer patients. Presented at 75th American Society of Reproductive Medicine Scientific Congress
- Florensa Bargalló M Cladellas Artola A Bellés Fernandez Jimenez Blasco M Herreros Cuesta J Huete Ferriz Garrido N Esbert Algam M Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology Copenhagen,Denmark Pre-Implantation genetics Relationship between both euploidy and thawing survival rates and embryo quality, day of biopsy or hatching status in Preimplantation Genetic Testing cycles Presented at 75th American Society of Reproductive Medicine Scientific Congress
- Mackens S Vieira-Silva S Santos-Ribeiro S Centelles-Lodeiro J Racca A Falony G Tito R Tournaye H Raes J Blockeel C Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology Copenhagen,Denmark IVF clinical O-077 Ovarian stimulation alters the cervical microbiota Presented at 75th American Society of Reproductive Medicine Scientific Congress
- Leaver M Kubikova N Tao X Jalas C Wells D Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology Copenhagen,Denmark Pre-Implantation genetics Technology development O-270 A nobel long-range DNA sequencing approach improves the design of new protocols for preimplantation genetic testing of monogenic disease (PGT-M). Presented at 75th American Society of Reproductive Medicine Scientific Congress
- Arnanz A De Munck N El Khatib I Bayram A El-Damen A Abdala A Melado L Lawrenz B Pacheco A Fatemi H Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology Copenhagen,Denmark IVF clinical Pre-Implantation genetics Vitamin D (VitD) in follicular fluid (FF) correlates with the euploid status of the embryo in a VitD deficient Middle Eastern population Presented at 75th American Society of Reproductive Medicine Scientific Congress
- Segers I Santos-Ribeiro S Mostinckx L Tournaye H Verheyen G De Vos M Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology Copenhagen,Denmark IVF clinical Cumulative live birth rates of oocyte in-vitro maturation and controlled ovarian stimulation in infertile patients with polycystic ovary syndrome Presented at 75th American Society of Reproductive Medicine Scientific Congress
- Albert C Del Gallego R Alegre A Larreategui Z Marcos J Aparicio Ruiz B Meseguer M O-109 The effect of high humidity on embryo culture media oxidation Presented at 75th American Society of Reproductive Medicine Scientific Congress
ASRM 2019
- Hanson BM Kim G Osman EK Tiegs AW Neal SA Werner MD Scott RT P-228 THE IMPACT OF OVARIAN RESPONSE ON CLINICAL PREGNANCY AND DELIVERY RATES IN AN OOCYTE DONOR POPULATION Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology
- Hariharan Meseguer M Toschi M Rocha CJ Zaninovic N Malmsten J Zhan Y Hickman C O-91 ARTIFICIAL INTELLIGENCE ASSESSMENT OF TIME-LAPSE IMAGES CAN PREDICT WITH 77% ACCURACY WHETHER A HUMAN EMBRYO CAPABLE OF ACHIEVING A PREGNANCY WILL MISCARRY Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology
- Yang M Tao X Zhao T Scott RT Seli E P-390 ANALYSIS OF ACCESSIBLE CHROMATIN LANDSCAPE IN THE INNER CELL MASS AND TROPHECTODERM OF HUMAN BLASTOCYSTS USING ATAC-SEQ Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology
- Bosch E Aasted H Klein BM Arce JC P-182 A randomized, doble-blind, placebo-controlled, multi-center, phase 2 trial to investigate the effect of barusiban on implantation in IVF/ICSI patients Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
- D. Castello Salom Del Gallego R Bori L Hervas I Alegre L Cnaani T Shnizer S Meseguer M P-232: High levels of Follicular fluid oxidative stress are present in younger patients and fertile donors Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ESHRE 2019
- Escrich L Soler N González Picazo A Buendía P Escribá MJ De los Santos MJ P-276: Effect of different commercial media on spontaneous in vitro maturation and kinetics of germinal-vesicle human oocytes Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
- Georgiou E Melo P Baker P Sallam H Arici A Garcia-Velasco JA Abou-Setta A Becker C Granne I O-208: Long-term gonadotrophin-releasing hormone agonist (GnRHa) therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with endometriosis: a Cochrane systematic review and meta-analysis Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
- Schutyser V Santos-Ribeiro S De Vos M Boudry L Tournaye H Blockeel C P-294: Should we care about polyps detected during the follicular phase of intrauterine insemination treatments? Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
- García-Acero P Alemán A Devesa-Peiro A Diaz-Gimeno P Drug-Target Model for Discovering and Personalizing Endometriosis Therapies. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2019
- Gonzalez-Martin R Quiñonero A Pérez-Debent S Salsano S Domínguez F Endometrial Stromal Cells Acutely Exposed to DEHP Do Not Recapitulate Alterations Observed in Endometriosis_ Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
- Scott RT Sun L Landis J Zhan Y Marin D Tao X Seli E Mitochondrial DNA Copy Number in Trophectoderm is Not a Predictive Biomarker for Human Embryo Viability Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
- Lara-Molina EE Franasiak JM Devesa-Peiro A Martin M Florensa M Lopez M Díaz-Gimeno P Pellicer A 24,25(oh)2d3: a novel accurate indicator of ovarian vitamin d status in women at reproductive age Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2018
- Fernandez-Sanchez M Visnova H Yuzpe A Klein BM Mannaerts B Arce JC Individualization of the starting dose of gonadotropin reduces the overall ohss risk and the need of preventive cumulative data over three Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
- Tao X Zhan Y Scott KL Scott RT Seli E Dna methylation is associated with ploidy status and patient age in human embryos Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Parker PB Morin SJ Neal SA Tiegs W Werner MD Inner cell mass and trophectoderm morphology impact the likelihood of achieving sustained implantation among expanded, euploid blastocysts Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Selles E Hernandez-Vargas P Garrido N Vilella F Perez-Cano I Muñoz M Looking for molecular biomarkers of cryodamage in donors semen Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Bosch E Howles C No difference in clinical outcomes using follitropin alfa (biosimilar) compared to follitropin alfa or follitropin beta for controlled ovarian stimulation (cos) in oocyte donation-recipient cycles Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Alecsandru D Iglesias C Pacheco A Barrio A Garrido N Garcia Velasco J HLA-C haplotypes distribution among gametes donors in our population Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ESHRE 2018
- Herrer Saura R Sciorio R Esbert M Pickering S Thong J Meseguer M Blastocysts collapse as an embryo marker of low implantation potential a Time-Lapse study Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Steyn F Wilson J Pringle F Denton J Bagness C Miller H Wedden Y Denga A Best K Mutch J Fertility nursing education and career progression framework Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
- Meseguer M Zaninovic N Nogueira F Nogueira O Oliana T Wilkinson L Using Artificial Intelligence (AI) and Time-Lapse to improve human blastocyst morphology evaluation Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
- Labarta E Herraiz S De Los Santos MJ Marzal A Jose Escribá M Buigues A Pellicer A Autologous stem cell ovarian transplant to improve ovarian response and reproductive outcomes in poor responder patients Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
- Beltran D Vásquez V De Los Santos MJ Do the environmental pollutants affect the mitochondrial content of human embryos? Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2017