Male fertility
Male factor is solely responsible for fertility issues in 20% of couples and contributes to an additional 30-40%. The semen analysis has been the benchmark of male fertility assessment for many decades, however wide variability in counts, motility and morphology contribute to the enigma of determining who benefits from fertility treatments including intra-uterine insemination and in-vitro fertilization with or without intra-cytoplasmic sperm injection.
More recently, delving in the world of DNA fragmentation has fueled the search for additional sperm quality parameters. Cutting edge questions are emerging including application of microfluidics devices for sperm isolation and epigenetic determinants of sperm quality and impact on offspring.
Investigators working in this area
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Publications from this area
- A new system of sperm cryopreservation: evaluation of survival, motility, DNA oxidation, and mitochondrial activity.
Pabón D Meseguer M Sevillano G Cobo A Romero JL Remohí J de Los Santos MJ
Andrology. 2019 Mar 27. doi: 10.1111/andr.12607. [Epub ahead of print]
- Assessment of the erectile function and patients' perception of improvement in Spanish patients with erectile dysfunction].
Balmori C Badiola C
Rev Int Androl, 16(2):67-74, 2018.
- Comparison of the SwimCount Home Diagnostic Test with Conventional Sperm Analysis
Castello D García-Laez V Buyru F Bakiricioglu E Ebbesen T Gabrielsen A Meseguer M
Advances in Andrology & Gynaecology, NA:NA-NA, 2018.
- Influence of temperature, serum, and gonadotropin supplementation in short- and long-term organotypic culture of human immature testicular tissue.
Medrano JV Vilanova-Pérez T Fornés-Ferrer V Navarro-Gomezlechon A Martínez-Triguero ML García S Gómez-Chacón J Povo I Pellicer A Andrés MM Novella-Maestre E
Fertil Steril, 110(6):1045-1057, 2018.
- Total urokinase-type plasminogen activator (uPA) levels in seminal plasma are associated with positive assisted reproductive technology outcomes.
Martínez-Soto JC Landeras J Molla M Mondejar I Nicolas M Fernández-Olmedilla L Trabalón M Coy P Gadea J
J Assist Reprod Genet , 35(6):1091-1101, 2018.
- The Status of Genetic Screening in Recurrent Pregnancy Loss.
Kaser DJ
Obstet Gynecol Clin North Am, 45(1):143-154, 2018.
- Pregnancy after vasectomy: surgical reversal or assisted reproduction?
Valerie U De Brucker S De Brucker M Vloeberghs V Drakopoulos P Santos-Ribeiro S Tournaye H
Tournaye H.Hum Reprod, 1;33(7):1218-27, 2018.
- Effect of dietary supplementation with a highly pure and concentrated docosahexaenoic acid (DHA) supplement on human sperm function.
González-Ravina C Aguirre-Lipperheide M Pinto F Martín-Lozano D Fernández-Sánchez M Blasco V Santamaría-López E Candenas L
Reprod Biol, 18(3):282-288, 2018.
- Spermatozoa with numerical chromosomal abnormalities are more prone to be retained by Annexin V-MACS columns.
Esbert M Godo A Soares SR Florensa M Amorós D Ballesteros A Vidal F
Andrology, 5(4):807-813, 2018.
- Human sperm testicular angiotensin-converting enzyme helps determine human embryo quality
Gianzo M Urizar-Arenaza I Muñoa-Hoyos I Larreategui Z Garrido N Casis L Irazusta J Subirán N
Asian J Androl, 20(5):498-504, 2018.
- Should we consider telomere length and telomerase activity in male factor infertility?
Balmori C Varela E
Curr Opin Obstet Gynecol, 30(3):197-202, 2018.
- Veratridine-sensitive Na+ channels regulate human sperm fertilization capacity.
Candenas L Pinto FM Cejudo Román A González-Ravina C Fernández-Sánchez M Pérez-Hernández Irazusta J Subirán N
Life Sci, 196:48-55, 2018.
- Total urokinase-type plasminogen activator (uPA) levels in seminal plasma are associated with positive assisted reproductive technology outcomes.
Martínez J Landeras J Molla M Mondejar I Nicolas M Fernández-Olmedilla L Trabalón M Coy P Gadea J
J Assist Reprod Genet , 35(6):1091-1101, 2018.
- Knowledge gaps in male infertility: an REI perspective.
Morin SJ Scott RT
Trans Androl Urol, 2018.
- Management of Radiation Therapy Oncology Group grade 4 urinary adverse events after radiotherapy for prostate cancer.
Mayer EN Tward JD Bassett M Lenherr SM Hotaling J Brant WO Lowrance WT Myers JB
BJU Int, 119(5), 700-708, 2017.
- A call for standardized outcomes in microTESE.
Jensen CF Dupree JM Sonksen J Ohl D Hotaling J
Andrology, 5(3), 403, 2017
- The impact of ejaculatory abstinence on semen analysis parameters: a systematic review.
Hanson BM Aston KI Jenkins TG Carrell DT Hotaling J
LID - 10.1007/s10815-017-1086-0 [doi]. [Review]. J Assist Reprod Genet. 2017.
- Amniotic therapeutic biomaterials in urology: current and future applications. [Review].
Oottamasathien S Hotaling J Craig JR Myers JB Brant WO
Transl Androl Urol, 6(5), 943-950, 2017.
- Serum Biomarkers of Erectile Dysfunction in Diabetes Mellitus: A Systematic Review of Current Literature. [Review].
Patel DP Craig JR Jr Myers JB Brant WO Hotaling J
Sex Med Rev, 5(3), 339-348, 2017.
- Obesity, male infertility, and the sperm epigenome. [Review].
Craig JR Jenkins TG Carrell DT Hotaling J
Fertil Steril, 107(4), 848-859, 2017.
- Urethral Strictures and Artificial Urinary Sphincter Placement. [Review]
Myers JB Brant WO Hotaling J Lenherr SM
Urol Clin North Am, 44(1), 93-103, 2017.
- Proton-pump inhibitor use does not affect semen quality in subfertile men.
Keihani S Craig JR Zhang C Presson AP Myers JB Brant WO Aston KI Emery BR Jenkins TG Carrell DT Hotaling J
LID - 10.4103/aja.aja_35_17 [doi]. (Epub ahead of print) Asian J Androl. 2017.
- Improving US databases for male fertility.
Anderson R Hotaling J
AUA News, 22(5), 10, 201
- Childhood Cancer Risk in the Siblings and Cousins of Men with Poor Semen Quality.
Anderson RE Hanson HA Lowrance WT Redshaw J Oottamasathien S Schaeffer A Johnstone E Aston KI Carrell DT Cartwright P Smith KR Hotaling J
J Urol, 197(3 Pt 2), 898-905, 2017.
- Sperm DNA damage output parameters measured by the alkaline Comet assay and their importance
Simon L Aston KI Emery BR Hotaling J Carrell DT
LID - 10.1111/and.12608 [doi]. Andrologia, 49(2), 2017.
- Risk of childhood mortality in family members of men with poor semen quality.
Hanson HA Mayer EN Anderson RE Aston KI Carrell DT Berger J Lowrance WT Smith KR Hotaling J
Hum Reprod, 32(1), 239-247, 2017.
- Cigarette smoking significantly alters sperm DNA methylation patterns.
Jenkins TG James ER Alonso DF Hoidal JR Murphy PJ Hotaling J Cairns BR Carrell DT Aston KI
Andrology, 5(6), 1089 1099,2017.
- Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development.
Guo J Grow EJ Yi C Mlcochova H Maher GJ Lindskog C Murphy PJ Wike CL Carrell DT Goriely A Hotaling J Cairns BR
Cell Stem Cell, 21(4), 533-546.e6, 2017.
- Amniotic therapeutic biomaterials in urology: current and future applications.
Oottamasathien S Hotaling J Craig JR Myers JB Brant WO
Transl Androl Urol, 6(5), 943-950, 2017.
- Impacts of Abstinence Time on Semen Parameters in a Large Population-based Cohort of Subfertile Men.
Keihani S Craig JR Zhang C Presson AP Myers JB Brant WO Aston KI Emery BR Jenkins TG Carrell DT Hotaling J
Urology, 108, 90-95, 2017.
- Longitudinal Patterns of Occurrence and Remission of Erectile Dysfunction in Men With Type 1 Diabetes.
Palmer MR Holt SK Sarma AV Dunn RL Hotaling J Cleary PA Braffett BH Martin C Herman WH Jacobson AM Wessells HJ
Sex Med, 14(10), 1187-1194, 2017.
- Male factor and oxidative stress.
Lopez G Martínez-Soto JC Amorós D
Cuadrenos de Andrología clínica. 1ª Edición, 2017.
- Antioxidant system in semen and exogenous supplementation.
Martínez-Soto JC Amorós D Lopez G
Cuadernos de Andrología clínica. 1ª Edición, 2017
- Sperm DNA fragmentation: from promising to estandarization
Pacheco A García-Velasco JA
Transl Androl Urol. 6 (Suppl 4):S341-S342, 2017
- Fertility treatment for the transgender community: a public opinion study.
Goldman RH Kaser DJ Missmer SA Farland LV Scout Ashby RK Ginsburg ES
J Assist Reprod Genet, 34:1457-1467. 2017.
- What the human sperm methylome tells us.
Camprubí C Cigliano RA Salas-Huetos A Garrido N Blanco J.
Epigenomics. 2017 Sep 7. doi: 10.2217/epi-2017-0049. [Epub ahead of print]
- Spermatozoa with numerical chromosomal abnormalities are more prone to be retained by Annexin V-MACS columns.
Esbert M Godo A Soares SR Florensa M Amorós D Ballesteros A Vidal F
Andrology. 2017 Jun 14. doi: 10.1111/andr.12376. [Epub ahead of print]
- Use of testicular sperm for intracytoplasmic sperm injection in men with high sperm DNA fragmentation: a SWOT analysis.
Esteves SC Roque M Garrido N
Asian J Androl. 2017 Apr 18. doi: 10.4103/aja.aja_7_17. [Epub ahead of print]
- Reproductive outcomes of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with high levels of DNA fragmentation in semen: systematic review and meta-analysis.
Esteves SC Roque M Bradley CK Garrido N
Fertil Steril. 2017 Sep;108(3):456-467.e1. doi: 10.1016/j.fertnstert.2017.06.018.
- Long-awaited long-term follow-up of reproductive parameters in female offspring conceived with the use of intracytoplasmic sperm injection.
Franasiak JM
Fertil Steril. 2017 Apr;107(4):908-909. doi: 10.1016/j.fertnstert.2017.02.111. Epub 2017 Mar 11. No abstract available.
- Fibroblast growth factor 2 (FGF2) is present in human spermatozoa and is related with sperm motility. The use of recombinant FGF2 to improve motile sperm recovery.
Garbarino Azúa DJ Saucedo L Giordana S Magri ML Buffone MG Neuspiller F Vazquez-Levin MH Marín-Briggiler CI
Andrology. 2017 Jul 21. doi: 10.1111/andr.12398. [Epub ahead of print]
- Clinical use of sperm DNA fragmentation analysis results, a practical example of how to deal with too much information from the literature in reproductive medicine.
Garrido N Rivera R Lujan S
Transl Androl Urol. 2017 Sep;6(Suppl 4):S547-S548. doi: 10.21037/tau.2017.03.54. No abstract available.
- What else can we do? The latest attempt to improve the sperm's path.
Meseguer M Pellicer A
Fertil Steril. 2017 Sep;108(3):444-445. doi: 10.1016/j.fertnstert.2017.07.003.
- Sperm DNA integrity: from 'promising' to standardization.
Pacheco A García-Velasco JA
Transl Androl Urol. 2017 Sep;6(Suppl 4):S341-S342. doi: 10.21037/tau.2017.08.10. No abstract available.
- Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation.
Martínez-Soto JC Domingo J Cordobilla B Nicolás M Fernández L Albero P Gadea J Landeras J
Syst Biol Reprod Med. 2016 Dec;62(6):387-395. Epub 2016 Oct 28.
- Same-sex reproduction: Medical treatment options and psychosocial considerations.
Greenfeld DA Seli E
Curr Opin Obstet Gynecol. 2016 Jun;28(3):202-5. doi: 10.1097/GCO.0000000000000266.
- Expanded carrier screening in an infertile population: how often is clinical decision making affected?
Franasiak JM Olcha M Bergh PA Hong KH Forman EJ Werner MD
Genet Med Off J Am Coll Med Genet 2016.
- Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality.
Cariati F Jaroudi S Alfarawati S Raberi A Alviggi C Pivonello R Wells D
Reprod Biomed Online, 33:404–411, 2016.
- Pros and cons of implementing a carrier genetic test in an infertility practice
Gil-Arribas E Herrer R Serna J
Curr Opin Obstet Gynecol, 28(3):172–7, 2016.
- Infertilidad masculina asociada a las microdelecciones del cromosoma Y. Opciones reproductivas y riesgos de la descendencia.
Hernandez P Mateu E Rubio C Pérez I Landeras J Muñoz M
Medicina Reproductiva y Embriología Clínica (MEDRE), 3(01): 45-55, 2016.
- CYP1A1 3801T>C polymorphism implicated in altered xenobiotic metabolism is not associated with variations in sperm production and function as measured by total motile sperm and fertilization rates wit
Franasiak JM Barnett R Molinaro T Gabriele D Gartmond TD Treff NR Scott RT
Fertil Steril. 106(2):481-6, 2016.
- The opioid peptide beta-endorphin stimulates acrosome reaction in human spermatozoa.
Urizar-Arenaza I Estomba H Muñoa-Hoyos I Matorras R Esposito A Candenas L Pinto FM Valdivia A Irazusta J Subirán N
Andrology, 4:143-51, 2016.
- Infertilidad masculina asociada a las microdeleciones del cromosoma Y. Opciones reproductivas y riesgos de la descendencia.
Hernández-Vargas P Mateu E Rubio C Pérez-Cano I Landeras J Muñoz M
Medicina Reproductiva y Embriología Clínica, 3:45-55, 2016.
- Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios.
Agarwal A Majzoub A Esteves SC Ko E Ramasamy R Zini A
Transl Androl Urol, 5:935-950, 2016.
- Spermatozoa from infertile patients exhibit differences of DNA methylation associated with spermatogenesis-related processes: an array-based analysis.
Camprubí C Salas-Huetos A Aiese-Cigliano R Godo A Pons M-C Castellano G Grossmann M Sanseverino W Martin-Subero JI Garrido N Blanco J
Reprod Biomed Online, 33:709-719, 2016.
- Angiotensin II type 2 receptor is expressed in human sperm cells and is involved in sperm motility.
Gianzo M Muñoa-Hoyos I Urizar-Arenaza I Larreategui Z Quintana F Garrido N Subirán N Irazusta J
Fertil Steril, 105:608-616, 2016.
- Obstetric and perinatal outcome of babies born from sperm selected by MACS from a randomized controlled trial.
Romany L Garrido N Cobo A Aparicio-Ruiz B Serra V Meseguer M
J Assist Reprod Genet, 34:201-207, 2016.
- Spermatozoa from normozoospermic fertile and infertile individuals convey a distinct miRNA cargo.
Salas-Huetos A Blanco J Vidal F Grossmann M Pons MC Garrido N Anton E
Andrology, 4:1028-1036, 2016.
- Decreased fecundity and sperm DNA methylation patterns.
Jenkins TG Aston KI Meyer TD Hotaling J Shamsi MB Johnstone EB Cox KJ Stanford JB Porucznik CA Carrell DT
Fertil Steril, 105(1), 51-7.e1-3, 2016.
- Subfertility increases risk of testicular cancer: evidence from population-based semen samples.
Hanson HA Anderson RE Aston KI Carrell DT Smith KR Hotaling J
Fertil Steril, 105(2), 322-8.e1, 2016.
- Non-steroidal anti-inflammatory drug (NSAID) use is not associated with erectile dysfunction risk: results from the Prostate Cancer Prevention Trial.
Patel DP Schenk JM Darke A Myers JB Brant WO Hotaling J
BJU Int, 117(3), 500-6, 2016.
- Surgical Management of Ureteral Strictures Arising From Radiotherapy for Prostate Cancer.
Orchard J Tward JD Lenherr S Hotaling J Brant WO Myers JB
Urol Case Rep, 6, 47-9, 2016.
- Optimization of microelectrophoresis to select highly negatively charged sperm.
Simon L Murphy K Aston KI Emery BR Hotaling J Carrell DT
J Assist Reprod Genet, 33(6), 679-88, 2016.
- Microfluidics: The future of microdissection TESE?
Samuel R Badamjav O Murphy KE Patel DP Son J Gale BK Carrell DT Hotaling J
Syst Biol Reprod Med, 62(3), 161-70, 2016.
- Teratozoospermia and asthenozoospermia are associated with specific epigenetic signatures.
Jenkins TG Aston KI Hotaling J Shamsi MB Simon L Carrell DT
Andrology, 4(5), 843-9, 2016.
- Cancer risk in first- and second-degree relatives of men with poor semen quality.
Anderson RE Hanson H Patel D Johnstone E Aston K Carrell D Lowrance W Smith K Hotaling J
Fertil Steril, 106(3), 731-8, 2016.
- Editorial Comment.
Craig JR Hotaling J Brant WO
J Urol, 196(4), 1089, 2016.
- Characterizing the safety of clomiphene citrate in male patients through prostate-specific antigen, hematocrit, and testosterone levels.
Chandrapal JC Nielson S Patel DP Zhang C Presson AP Brant WO Myers JB Hotaling J
Br J Urol, 118(6), 272, 2016.
- Predictors of sperm recovery after cryopreservation in testicular cancer.
Hotaling J Patel DP Vendryes C Lopushnyan NA Presson AP Zhang C Muller CH Walsh TJ
Asian J Androl, 18(1), 35-8, 2016.
- Fertility treatment in spinal cord injury and other neurologic disease. [Review].
Trofimenko V Hotaling J
Transl Androl Urol, 5(1), 102-16, 2016.
- Hormone-Based Treatments in Subfertile Males. [Review].
Patel DP Chandrapal JC Hotaling J
Curr Urol Rep, 17(8), 56, 2016.
- Claims-based analysis of male infertility: a cautious step in the right direction.
Schaeffer A Hotaling J
Fertil Steril, 105(3), 599-600, 2016.
- Building a model to increase live birth rate through patient-specific optimization of embryo transfer day.
Goldman RH Kaser DJ Farland L Missmer S Srouji S Racowsky C
J Assist Reprod Genet, 33:1525-32. 2016.
- Study of nucleation status in the second cell cycle of human embryo and its impact on implantation rate.
Aguilar J Rubio I Muñoz E Pellicer A Meseguer M
Fertil Steril, 106:291-299.e2, 2016.
- A combination of hydroxypropyl cellulose and trehalose as supplementation for vitrification of human oocytes: a retrospective cohort study.
Coello A Campos P Remohí J Meseguer M Cobo A
J Assist Reprod Genet, 33:413-421, 2016.
- Blastocyst development in single medium with or without renewal on day 3: a prospective cohort study on sibling donor oocytes in a time-lapse incubator.
Costa-Borges N Bellés M Meseguer M Galliano D Ballesteros A Calderón G
Fertil Steril, 105:707-713, 2016
- Examining potential reasons why euploid blastocysts do not always implant. Part 1. Optimizing the culture environment and embryo manipulation to maintain viability.
Swain J Carrell D Cobo A Meseguer M Rubio C Smith G
Fertil Steril, 105: 571-87, 2016.
- Local and systemic factors and implantation: what is the evidence?
Fox C Morin SJ Jeong JW Scott RT Lessey BA
Fertil Steril 2016;105(4):873-84.
- Human spermatogonial stem cells display limited proliferation in vitro under mouse spermatogonial stem cell culture conditions.
Medrano JV Rombaut C Simón C Pellicer A Goossens E
Fertil Steril, 106 (6): 1539-1549.e8, 2016.
- CYP1A1 3801T>C Polymorphism is not Associated with Variations in Total Motile Sperm or Fertilization Rates with ICSI.
Franasiak JM Barnett R Treff N Scott RT
Fertil Steril, 106:481-6, 2016.
- IVF: a short but exciting story.
García-Velasco JA Seli E
Curr Opin Obstet Gynecol, 27:165-6, 2015.
- How to Perform the Best Intrauterine Insemination? A Review. Andrology-Open Access.
Carranza F Santamaría E González-Ravina C Blasco V Caligara C Fernández-Sánchez M
4 - 2, pp. 1 - 7. OMICS group, 2015.
- Understanding the new WHO semen parameters. Infertility Management Series 2: Practical Management of Male Infertility.
González-Ravina C Pacheco A
Handbook. Jaypee Brothers Medical Publisher, 2015.
- Investigating the subfertile male: which tests are practically relevant? Infertility Management Series 2: Practical Management of Male Infertility.
Pacheco A González-Ravina C
Handbook. Jaypee Brothers Medical Publisher, 2015.
- Successful ICSI in an azoospermic and kidney transplant man with type 1 primary hyperoxaluria and first histopathological testicular findings described in the literature.
Balmori C Guillén A Montans J Bronet F García-Velasco JA
Andrologia, 47:109-11, 2015.
- Comprehensive carrier genetic test using next-generation deoxyribonucleic acid sequencing in infertile couples wishing to conceive through assisted reproductive technology
Martin J Asan Y Alberola T Rodríguez-Iglesias B Jiménez-Almazán J Li Q Du H Alama P Ruiz A Bosch E Garrido N Simón C
Fertil Steril, 104(5):1286-93, 2015.
- Immune testing and treatment: still an open debate.
Alecsandru D García-Velasco JA
Hum Reprod, 2015
- Immunology and human reproduction.
Alecsandru D García-Velasco JA
Curr Opin Obstet Gynecol, 27(3):231-4, 2015
- Comprehensive carrier genetic test using next-generation deoxyribonucleic acid sequencing in infertile couples wishing to conceive through assisted reproductive technology.
Martin J Asan Yi Y Alberola T Rodríguez-Iglesias B Jiménez-Almazán J Li Q Du H Alama P Ruiz A Bosch E Garrido N Simón C
Fertil Steril, 104:1286-1293, 2015.
- Sperm selection in natural conception: what can we learn from Mother Nature to improve assisted reproduction outcomes?
Sakkas D Ramalingam M Garrido N Barratt CLR
Hum Reprod Update, 21:711-726, 2015
- Spermatozoa from patients with seminal alterations exhibit a differential micro-ribonucleic acid profile.
Salas-Huetos A Blanco J Vidal F Godo A Grossmann M Pons MC F-Fernández S Garrido N Anton E
Fertil Steril, 104:591-601, 2015.
- A novel method to determine perineal artery occlusion among male bicyclists.
Parthiban S Hotaling J Kathrins M Baftiri A Freels S Niederberger C
PeerJ, 3, e1477, 2015.
- Micro-electrophoresis: a noninvasive method of sperm selection based on membrane charge.
Simon L Murphy K Aston K Emery B Hotaling J Carrell D
Fertil Steril, 103(2), 361-6.e3, 2015.
- Effect of male and female body mass index on pregnancy and live birth success after in vitro fertilization.
Schliep K Mumford S Ahrens K Hotaling J Carrell D Link M Hinkle S Kissell K Porucznik C Hammoud A Fertil Steril, 103(2), 388-95, 2015.
Fertil Steril, 103(2), 388-95, 2015.
- Poor glycemic control is associated with reduced prostate specific antigen concentrations in men with type 1 diabetes.
Sarma AV Hotaling J Dunn R Cleary P Braffett B Kim C Martin C Herman W Gatcomb P acobson A Holt S Wessells H
J Urol, 193(3), 786-93, 2015.
- Intra-sample heterogeneity of sperm DNA methylation.
Jenkins TG Aston K Trost C Farley J Hotaling J Carrell D
Mol Hum Reprod, 21(4), 313-9, 2015.
- Sperm concentration is poorly associated with hypoandrogenism in infertile men.
Patel DP Brant WO Myers JB Zhang C Presson A Johnstone E Dorais J Aston KI Carrell D Hotaling J
Urology, 85(5), 1062-7, 2015.
- Cardiovascular autonomic neuropathy, erectile dysfunction and lower urinary tract symptoms in men with type 1 diabetes: findings from the DCCT/EDIC.
Pop-Busui R Hotaling J Braffett BH Cleary P Dunn RL Martin C Jacobson A Wessells H Sarma A
J Urol, 193(6), 2045-51, 2015.
- Demographic and socio-economic differences between men seeking infertility evaluation and those seeking surgical sterilization: from the National Survey of Family Growth.
Son J Murphy K Samuel R Gale B Carrell D Hotaling J
BJU Int, 116(2), 288-92, 2015.
- The safety and efficacy of clomiphene citrate in hypoandrogenic and subfertile men.
Patel D Brant W Myers J Presson A Johnstone E Dorais J Aston K Carrell D Hotaling J
nt J Impot Res, 27(6), 221-4, 2015.
- Non-motile sperm cell separation using a spiral channe
Son J Murphy K Samuel R Gale B Carrell D Hotaling J
Anal Methods, 7, 8041-8047, 2015.
- Targeted Germline Modifications in Rats Using CRISPR/Cas9 and Spermatogonial Stem Cells.
Chapman K Medrano G Jaichander P Chaudhary Waits A Nobrega M Hotaling J Ober C Hamra F
Cell Rep, 10(11), 1828-35, 2015.
- Cancer risk in first and second degree relatives of men with poor semen quality.
Anderson R Hanson HAston K Carrell D Smith K Hotaling J
Demography. 2015
- MicroRNA: a step beyond bulk seminal parameters?
Hotaling J Jenkins T
Fertil Steril, 104(3), 554, 2015.
- Inherent difficulties of meta-analysis for surgical techniques in male infertility: an argument for standardizing reporting and outcomes.
Anderson R Hotaling J
Fertil Steril, 104(5), 1127-8, 2015.
- Global deoxyribonucleic acid methylation: a window into the spermatogonial stem cell's reproductive potential.
Hotaling J
Fertil Steril, 104(6), 1374-5, 2015.
- The Separation of Sexual Activity and Reproduction in Human Social Evolution.
Morin SJ Naftolin F Keefe D
Adv Exp Med Biol 2014;814:159-67
- Understanding mammlian germ line development with in Vitro Models.
Martínez-Arroyo A Minguez J Remohí J Pellicer A Medrano J
Stem Cell Dev, 24(18); 2101-13, 2015.
- Introduction: Microbiome in human reproduction.
Franasiak JM Scott RT
Fertil Steril, 104:1341-3, 2015.
- Successful ICSI in an azoospermic and kidney transplant man with type 1 primary hyperoxaluria and first histopathological testicular findings described in the literature
Balmori C Guillén A Montans J Bronet F García-Velasco JA
Andrologia. 47:109-11, 2015.
- Ejaculatory sperm production in non-obstructive azoospermic patients with a history of negative testicular biopsy after the administration of an aromatase inhibitor: report of two cases.
Kyrou D Kosmas IP Popovic-Todorovic B Donoso P Devroey P Fatemi HM
Eur J Obstet Gynecol Reprod Biol, 173:120-121, 2014.
- Epab is dispensable for Spermatogenesis and Male Fertility in Mice.
Ozturk S Guzeloglu-Kayisli O Lowther K Lalioti MD Sakkas D Seli E
Mol Reprod Dev, 81:390, 2014. *equal first authors.
- Intrauterine Insemination.
Domínguez Y Rubio I Herrero J
Chapter 12: Design, Equipment and Personnel Management for Intrauterine Insemination Laboratory.” Jaypee Brothers Medical Publishers, 2014.
- Sperm DNA Fragmentation, Recurrent Implantation Failure and Recurrent Miscarriage
Coughlan C Clarke H Cutting R Saxton J Waite S Ledger W Li T Pacey A
Asian Journal of Andrology, 2014.
- Removal of annexin V–positive sperm cells for intracytoplasmic sperm injection in ovum donation cycles does not improve reproductive outcome: a controlled and randomized trial in unselected males.
Romany L Garrido N Motato Y Aparicio B Remohí J Meseguer M
Fertil Steril, 102:1567-1575.e1, 2014.
- New insights into the expression profile and function of micro-ribonucleic acid in human spermatozoa.
Salas-Huetos A Blanco J Vidal F Mercader J Garrido N Anton E
Fertil Steril, 102:213-222.e4, 2014.
- Presente y futuro de la evaluación del semen con finalidad reproductiva en un centro de reproducción asistida
Garrido N
Revista Iberoamericana de Fertilidad, 2014
- Spontaneous recovery from reproductive failure in a hand reared male western lowland gorilla (Gorilla gorilla gorilla).
Casares M Garrido N Vidal J Martínez-Jabaloyas JM Gerique AC Carbonell MD
Zoo and Aquarium Research, 2:22-24, 2014.
- Men with diabetes may require more aggressive treatment for erectile dysfunction.
Walsh TJ Smith A Saigal C Wessells H
Int J Impot Res, May-Jun;26(3), 112-115, 2014.
- Persistence of urothelial carcinoma of the bladder risk among former smokers: results from a contemporary, prospective cohort study.
Welty C Wright J Hotaling J Bhatti P Porter M White E
Urol Oncol, 32(1), 25.e21-5, 2014.
- Prevalence of Androgen Deficiency and Predisposing Risk Factors in Men with Type I Diabetes Mellitus: Findings from the DCCT/EDIC.
Holt S Lopushnyan N Hotaling J Sarma A Wessells H
J Clin Endocrinol Metab. 2014
- Variants in DPF3 and DSCAML1 are associated with sperm morphology.
Kosova G Hotaling J Ohlander S Niederberger C Prins GS Ober C
J Assist Reprod Genet, 31(2), 131-7, 2014
- Impact of fresh versus cryopreserved testicular sperm upon intracytoplasmic sperm injection pregnancy outcomes in men with azoospermia due to spermatogenic dysfunction: a meta-analysis.
Ohlander S Hotaling J Kirshenbaum E Niederberger C Eisenberg M
Fertil Steril, 101(2), 344-9, 2014
- Clinical genetic testing for male factor infertility: current applications and future directions.
Hotaling J Carrell DT
Andrology, 2(3), 339-50, 2014
- Comparative analysis of three sperm DNA damage assays and sperm nuclear protein content in couples undergoing assisted reproduction treatment.
Simon L Liu L Murphy K Ge S Hotaling J Aston KI Emery B Carrell DT
Hum Reprod, 29(5), 904-17, 2014
- Simple circumcision device: proof of concept for a single-visit, adjustable device to facilitate safe adult male circumcision.
Kadlec AO Ohlander S Hotaling J Hannick J Niederberger C Turk TM
Urolithiasis, 42(4), 323-7, 2014.
- Prevalence of low testosterone and predisposing risk factors in men with type 1 diabetes mellitus: findings from the DCCT/EDIC.
Holt SK Lopushnyan N Hotaling J Sarma A Dunn R Cleary P Braffett B Gatcomb P Martin C Herman W Wessells H
J Clin Endocrinol Metab, 99(9), E1655-60, 2014.
- Paternal influence of sperm DNA integrity on early embryonic development.
Simon L Murphy K Shamsi MB Liu L Emery B Aston KI Hotaling J Carrell DT
Hum Reprod, 29(11), 2402-12, 2014.
- Male endocrine dysfunction. [Review].
Hotaling J Patel Z
Urol Clin North Am, 41(1), 39-53, 2014.
- Genetics of male infertility. [Review].
Hotaling J
Urol Clin North Am, 41(1), 1-17, 2014.
- Management of adults with prior failed hypospadias surgery. [Review].
Craig JR Wallis C Brant WO Hotaling J Myers JB
Transl Androl Urol, 3(2), 196-204, 2014.
- Refined phenotyping, large cohorts, and collaborative research are vital for realizing the potential of genomics to transform care for male infertility.
Hotaling J Aston KI Carrell DT
Fertil Steril, 102(4), 967, 2014.
- Germ cell transplantation into mouse testes procedure
Medrano JV Martínez-Arroyo A Sukhwani M Noguera I Quiñonero A Martínez-Jabaloyas J Pellicer A Remohí J Orwig K Simón C
Fertil Steril, 102(4);e11-2; 2014
- Removal of annexin V-positive sperm cells for intracytoplasmic sperm injection in ovum donation cycles does not improve reproductive outcome: a controlled and randomized trial in unselected males.
Romany L Garrido N Motato Y Aparicio B Remohí J Meseguer M
Fertil Steril, 102(6);1567-75, 2014.
- Germ line development: lessons learned from pluripotent stem cells.
Martínez-Arroyo A Medrano J Remohí J Simón C
Curr Opin Genet Dev, 28;64-70, 2014.
- Lack of association of KATNAL1 gene sequence variants and azoospermia in humans.
Fedick AM Eckert K Thompson K Forman EJ Devkota B Treff NR Taylor D Scott RT
J Assist Reprod Genet, 31:1065-71, 2014.
- Obesity and poor reproductive outcome: female and male body weight matter
Bellver J
Fertil Steril, 99:1558-9, 2013.
- To preserve or not to preserve: How difficult is the decision about fertility preservation?
Mersereau JE Goodman L Deal AM Gorman JR Whitcomb BW Su HI
Cancer. 2013 Nov 15;119(22):4044-50.
- The voltage-gated sodium channel Nav1.8 is expressed in human sperm.
Cejudo Román A Pinto FM Subirán N Ravina CG Fernández-Sánchez M Pérez-Hernández N Pérez R Pacheco A Irazusta J Candenas L
PLoS One, 8:e76084, 2013.
- Spermatozoa and seminal plasma fatty acids as predictors of cryopreservation success.
Martínez-Soto JC Landeras J Gadea J
Andrology, 1(3):365-75, 2013.
- Genetics of the germ line formation.
Ilbay O Seli E
In: C. Simon, A. Pellicer and R. Reijo-Pera, eds. Stem Cells in Reproductive Medicine. 3nd ed. Cambridge, UK, Cambridge University Press, pp 1-14, 2013.
- The transcriptome of follicular cells: biological insights and clinical implications for the treatment of infertility.
Fragouli E Lalioti MD Wells D
Hum Reprod Update, 20:1–11, 2013.
- Increased numbers of DNA-damaged spermatozoa in samples presenting an elevated rate of numerical chromosome abnormalities.
Enciso M Alfarawati S Wells D
Hum Reprod, 28:1707–1715, 2013.
- Gamete and embryo assessment in assisted reproduction: emerging technologies
Gardner D Sakkas D Seli E Wells D
(Springer Scientific). 2013.
- Lack of association of MTHFR rs1801133 polymorphism and CTCFL mutations with sperm methylation errors in infertile patients
Camprubí C Pladevall M Grossmann M Garrido N Pons MC Blanco J
J Assist Reprod Genet, 30:1125-1131, 2013.
- Filling the void about sperm function knowledge and how the -omics approach can close the circle.
Garrido N
Fertil Steril, 100:349-350, 2013.
- Assessment of sperm using mRNA microarray technology.
Garrido N García-Herrero S Meseguer M
Fertil Steril, 99:1008-1022, 2013.
- Raw and test-thaw semen parameters after cryopreservation among men with newly diagnosed cancer.
Hotaling J Lopushnyan NA Davenport M Christensen H Pagel ER Muller CH Walsh TJ
Fertil Steril, 99(2), 464-9, 2013.
- How curved is too curved? The severity of penile deformity may predict sexual disability among men with Peyronie's disease.
Walsh TJ Hotaling J Lue TF Smith J
Int J Impot Res, 25(3), 109-12, 2013.
- Publication misrepresentation among urology residency applicants.
SHsi RS Hotaling J Moore TN Joyner BD
World J Urol, 31(3), 697-702, 2013.
- Validity and reliability of a smartphone application for the assessment of penile deformity in Peyronie's disease.
Hsi RS Hotaling J Hartzler AL Holt SK Walsh TJ
J Sex Med, 10(7), 1867-1873, 2013.
- White E. Long-term NSAID use and incident urothelial cell carcinoma in the VITamins and Lifestyle (VITAL) study
Shih C Hotaling J Wright JL
Urol Oncol, 31(8), 1689-95, 2013.
- Finasteride and male infertility: a case for prospective collaborative research databases?
Hotaling J
Fertil Steril, 100(6), 1528-1529, 2013.
- Failures (with some successes) of assisted reproduction and gamete donation programs.
ESHRE Capri Workshop Group Pellicer A
Hum Reprod Update, 19 (4): 354-365, 2013.
- Could Safety Boards provide a valuable took to enhance the safety of reproductive medicine?
Scott RT DeZiegler N
Fertil Steril, 100: 1518-1523, 2013.
- The Paradigm of Clinical IVF is shifting: The Time to Incorporate Validated Technologies and an Enhanced Understanding of Physiology is now.
Hong KH Scott RT
J Clin Embryology, 16:104-106, 2013.
- Sperm DNA fragmentation index does not correlate with the sperm or embryo aneuploidy rate in recurrente miscarriage or implantation failure patients.
Bronet F Martínez E Gaytan M Liñán A Cernuda D Ariza M Nogales M Pacheco A San celestino M García-Velasco JA
Hum Reprod 27: 1922-9, 2012
- Epab and Pabpc1 are differentially expressed during male germ cell development.
Ozturk S Guzeloglu-Kayisli O Demir N Lalioti MD Seli E
Reprod Sci,19:911-22, 2012.
- Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLC?) from an infertile man by use of minisequencing of individual sperm and expression in somatic
Kashir J Konstantinidis M Jones C Heindryckx B Sutter P De Parrington J Wells D Coward K
Fertil Steril, 98:423–431, 2012.
- Development of a novel synthetic oligopeptide for the detection of DNA damage in human spermatozoa.
Enciso M Pieczenik G Cohen J Wells D
Hum Reprod, 27:2254–2266, 2012.
- The impact of cigarette smoking on the health of descendants.
Mello M Bellver J Soares SR
Expert Rev Obstet Gynecol, 7(2):167-174, 2012.
- Exam of fresh semen. Manual práctico de esterilidad y Reproducción Humana.
Molla M Pabón D Ojeda M Martínez E Muñoz E Pellicer A
Laboratorio de Reproducción Asistida, 2012.
- Manual práctico de esterilidad y Reproducción Humana
Molla M Tejera A Muriel L
Laboratorio de Reproducción Asistida, 2012.
- Spermatozoa and seminal plasma fatty acids as predictors of cryopreservation success
Martínez-Soto JC Landeras J Gadea J
Andrology, 1:365-375, 2012
- Estados Intersexuales y Disgenesias. Síndrome de Morris (pseudohermafroditismos masculinos)
Guillén V Domingo J Remohí J
In Casos Clínicos de Ginecología y Obstetricia, Editorial Panamericana. ISBN:978-84-9835-396-9, 2012.
- Characterization of the kisspeptin system in human spermatozoa
Pinto FM Cejudo Román A González-Ravina C Fernández-Sánchez M Martín-Lozano D Illanes M Tena-Sempere M Candenas L
Int J Androl 35:63-73, 2012
- Autocrine regulation of human sperm motility by the met-enkephalin opioid peptide.
Subirán N Candenas L Pinto FM Cejudo Román A Agirregoitia E Irazusta J
Fertil Steril, 98:617-625, 2012
- Sperm DNA fragmentation index does not correlate with the sperm or embryo aneuploidy rate in recurrent miscarriage or implantation failure patients.
Bronet F Martínez E Gaytán M Liñán A Cernuda D Ariza M Nogales M Pacheco A San Celestino M García-Velasco JA
Hum Reprod, 27:1922-29, 2012
- Semen samples showing an increased rate of spermatozoa with imprinting errors have a negligible effect in the outcome of assisted reproduction techniques.
Camprubí C Pladevall M Grossmann M Garrido N Pons M Blanco J
Epigenetics, 7:1115-1124, 2012.
- Increasing the success of assisted reproduction by defining sperm fertility markers and selecting sperm with the best molecular profile.
Rivera R Meseguer M Garrido N
Expert Rev Obstet Gynecol, 7:347-362, 2012.
- Factores moleculares de infertilidad en el espermatozoide más allá del Manual de la Organización Mundial de la Salud de 2010.
Nohales M Remohí J Pellicer A Garrido N
Revista Iberoamericana de Fertilidad, 7(10), 2012.
- Lavado de semen de varones seropositivos al VIH. ¿Está todo resuelto?
Galbis C Remohí J Pellicer A Garrido N
Revista de ASEBIR, 2012.
- Men who seek infertility care may not represent the general U.S. population: data from the National Survey of Family Growth.
Hotaling J Davenport MT Eisenberg ML VanDenEeden SK Walsh TJ
Urology, 79(1), 123-7, 2012.
- Performance of total testosterone measurement to predict free testosterone for the biochemical evaluation of male hypogonadism.
Anawalt BD Hotaling J Walsh TJ Matsumoto AM
J Urol, 187(4), 1369-73, 2012
- Erectile dysfunction is not independently associated with cardiovascular death: data from the vitamins and lifestyle (VITAL) study.
Hotaling J Walsh TJ Macleod LC Heckbert S Pocobelli G Wessells H White E
J Sex Med, 9(8), 2104-2110, 2012.
- Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohor
Hotaling J Waggott DR Goldberg J Jarvik G Paterson AD Cleary PA Lachin J Sarma A Wessells H
J Urol, 188(2), 514-20, 2012.
- Lavado Seminal en varones seropositivos para el VIH ¿está todo resuelto?
Galbis MC Remohí J Pellicer A Garrido N
ASEBIR, 17 (1); 28-39, 2012.
- Assessment of two thawing processes of cryopreserved human sperm in pellets.
Martínez-Soto JC García-Vazquez FA Gumbao D Landeras J Gadea J
Cryobiology, 63:131-136, 2011
- Gay men choosing parenthood through assisted reproduction: medical and psychological considerations
Greenfeld D Seli E
Fertil Steril, 95:225-9, 2011.
- Donor Sperm Insemination Cycles: Are Two Inseminations Better Than One?
Chavkin D Molinaro T Roe A Sammel M Dokras A.
J Androl. 2011 Jun 2.
- A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC?) leads to male infertility.
Kashir J Konstantinidis M Jones C Lemmon B Lee HC Hamer R Heindryckx B Deane CM De Sutter P Fissore RA Parrington J Wells D Coward K
Hum Reprod, 27:222–231, 2011.
- Reproductive medicine and beyond.
Wells D
Expert Rev Obstet Gynecol, 6:371–376, 2011.
- Impact of sperm DNA fragmentation on the outcome of IVF with own or donated oocytes.
Esbert M Pacheco A Vidal F Florensa M Riqueros M Ballesteros A Garrido N Calderón G
Reprod Biomed Online, 23:704-710, 2011.
- Effect of sperm DNA fragmentation on pregnancy outcome depends on oocyte quality
Meseguer M Santiso R Garrido N García-Herrero S Remohí J Fernandez JL
Fertil Steril, 95:124-128, 2011.
- Long-term use of supplemental vitamins and minerals does not reduce the risk of urothelial cell carcinoma of the bladder in the VITamins And Lifestyle study.
Hotaling J Wright JL Pocobelli G Bhatti P Porter MP White E
J Urol, 185(4), 1210-5, 2011.
- The relationship between isolated teratozoospermia and clinical pregnancy after in vitro fertilization with or without intracytoplasmic sperm injection: a systematic review and meta-analysis. [Review]
Hotaling J Smith JF Rosen M Muller CH Walsh TJ
Fertil Steril, 95(3), 1141-5, 2011
- Differential transcriptomic profile in spermatozoa achieving pregnancy or not via ICSI.
García-Herrero S Garrido N Martínez-Conejero JA Remohí J Pellicer A Meseguer M
Reprod Biomed Online, 22:25-36, 2011.
- Effect of sperm DNA fragmentation on pregnancy outcome depends on oocyte quality.
Meseguer M Santiso R Garrido N García-Herrero S Remohí J Fernandez JL
Fertil Steril, 95:124-128, 2011.
- Fertility after age 45: From natural conception to assisted reproductive technology and beyond.
Forman EJ Treff NR Scott RT
Maturitas, 70:216-221, 2011.
- Effect of genistein supplementation of thawing medium on characteristics of frozen spermatozoa.
Martínez-Soto JC Hourcade J Gutierrez Adán Alfonso Landeras J Gadea J
Asian J Androl, 12(3):431-41, 2010.
- Impacto de un complejo de antioxidantes sobre la fragmentación del ADN espermático en varones infértiles
Balmori C Areces C Pacheco A San Celestino M García-Velasco JA
Rev Int Androl 8: 107-13, 2010
- Relevance of testicular sperm DNA oxidation for the outcome of ovum donation cycles.
Aguilar C Meseguer M García-Herrero S Gil-Salom M O'Connor JE Garrido N
Fertil Steril, 94:979-988, 2010
- Y chromosome microdeletions, sperm DNA fragmentation and sperm oxidative stress as causes of recurrent spontaneous abortion of unknown etiology.
Bellver J Meseguer M Muriel L Garcia-Herrero S Barreto MAM Garda AL Remohí J Pellicer A Garrido N
Hum Reprod, 25:1713-1721, 2010.
- Ontological evaluation of transcriptional differences between sperm of infertile males and fertile donors using microarray analysis.
García-Herrero S Garrido N Martínez-Conejero JA Remohí J Pellicer A Meseguer M
J Assist Reprod Genet, 27:111-120, 2010.
- The transcriptome of spermatozoa used in homologous intrauterine insemination varies considerably between samples that achieve pregnancy and those that do not.
García-Herrero S Meseguer M Martínez-Conejero JA Remohí J Pellicer A Garrido N
Fertil Steril, 94:1360-1373, 2010.
- Comparative analysis of the germ cell markers c-KIT, SSEA-1 and VASA in testicular biopsies from secretory and obstructive azoospermias.
Medrano JV Marqués-Marí AI Aguilar CE Riboldi M Garrido N Martínez-Romero A O'Connor E Gil-Salom M Simón C
MHR: Basic science of reproductive medicine, 16:811-817, 2010.
- Autocrine regulation of human sperm motility by tachykinins
Pinto FM Ravina CG Subiran N Cejudo Román A Fernández-Sánchez M Irazusta J Garrido N Candenas L
Reprod Biol Endocrinol, 8:104, 2010.
- Swim-up procedure selects spermatozoa with longer telomere length.
Santiso R Tamayo M Gosálvez J Meseguer M Garrido N Fernández JL
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 688:88-90, 2010.
- Simultaneous determination in situ of DNA fragmentation and 8-oxoguanine in human sperm.
Santiso R Tamayo M Gosálvez J Meseguer M Garrido N Fernández JL
Fertil Steril, 93:314-318, 2010
- Cigarette smoking affects specific sperm oxidative defenses but does not cause oxidative DNA damage in infertile men.
Viloria T Meseguer M Martínez-Conejero JA O'Connor JE Remohí J Pellicer A Garrido N
Fertil Steril, 94:631-637, 2010.
- Las muestras de semen de pacientes infértiles que se someten a una ICSI o IAH difieren considerablemente en sus perfiles de expresión génica
García-Herrero S Garrido N Pellicer A Remohí J Martínez-Conejero JA Meseguer M
Revista del Laboratorio Clínico, 2010.
- Third party reproduction and the aging couple.
Luk J Greenfeld D
Maturitas, 66:389-96, 2010.
- Profound Transcriptomic Differences Found between Sperm Samples from Sperm Donors vs. Patients Undergoing Assisted Reproduction Techniques Tends to Disappear after Swim-up Sperm Preparation Technique.
García-Herrero S Garrido N Pellicer A Remohí J Martínez-Conejero JA Meseguer M
J Assist Reprod Genet, 27:111-120, 2010.
- Perfiles de expresión génica en hombres infértiles que se someten a reproducción asistida.
García-Herrero S Meseguer M Martínez-Conejero JA Remohí J Pellicer A Garrido N
Fertil Steril, 94:1360-1373, 2010.
- Y chromosome microdelections, sperm DNA fragmentation andsperm oxidative as causes of recurrent of unknown etiology.
Bellver J Meseguer M Muriel L García-Herrero S Barreto MA Grada AL Remohí J Pellicer A Garrido N
Human Reprod, 25(7):1713-21, 2010.
- Aneploidies in embryos and spermatozoa from patients with Y chromosome microdelections.
Mateu E Rodrigo L Martínez MC Peinedo V Delagado A MIr P Simón C Remohí J
Reprod Biomed Online, 21(5); 649-57, 2010.
- Reproduction in Couples with Chronic Viral Infections.
Giles J Vidal C Fortuño S Be J
Current Women’s Health Reviews, 5, 130-148, 2009
- Should sperm parameters be considered in patient selection for SET?
Sakkas D El-Fakahany HM Seli E
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- First report of the absence of viral load in testicular sperm samples obtained from men with hepatitis C and HIV after washing and their subsequent use.
Garrido N Gil-Salom M Martínez-Jabaloyas JM Meseguer M
Fertil Steril, 92:1012-1015, 2009.
- Microarray analysis in sperm from fertile and infertile men without basic sperm analysis abnormalities reveals a significantly different transcriptome.
Garrido N Martínez-Conejero JA Jauregui J Horcajadas JA Simón C Remohí J Meseguer M
Fertil Steril, 91:1307-1310, 2009.
- GnRH agonist versus recombinant HCG in an oocyte donation programme: a randomized, prospective, controlled, assessor-blind study.
Melo M Busso CE Bellver J Alama P Garrido N Meseguer M Pellicer A Remohí J
Reprod Biomed Online, 19:486-492, 2009.
- Sperm DNA fragmentation levels in testicular sperm samples from azoospermic males as assessed by the sperm chromatin dispersion (SCD) test.
Meseguer M Santiso R Garrido N Gil-Salom M Remohí J Fernandez J
Fertil Steril, 92:1638-1645, 2009.
- Integridad del ADN y patrón de expresión génica indicadores de calidad espermática y éxito reproductivo
Meseguer M García-Herrero S Aguilar C Viloria T Garrido N
ASEBIR, 2009.
- Métodos para la selección objetiva de espermatozoides competentes
Romany L Meseguer M Remohí J Pellicer A Garrido N
Revista Iberoamericana de Fertilidad 26 (5), 2009.
- Predictors of Upper Tract Urothelial Cell Carcinoma after Primary Bladder Cancer: A Population Based Analysis.
Wright JL Hotaling J Porter MP
J Urol, 181(3), 1035-1039, 2009.
- Male infertility: a risk factor for testicular cancer. [Review].
Hotaling J Walsh TJ
Nat Rev Urol, 6(10), 550-6, 2009.
- Métodos de selección objetiva de espermatozoides competentes.
Romany L Meseguer M Remohí J Pellicer A Garrido N
Revista Iberoamericana de Fertilidad y Reproducción Humana Clave, 26: 425-435, 2009.
- Biochemical markers of male infertility: the key role of DNA damage.
Aguilar C Garrido N Viloria T Fernandez JL Meseguer M
Expert Review of Obstetrics & Gynecology, 3:4, 565-576, DOI: 10.1586/17474108.3.4.565
- Infertility.
Rackow B Seli E
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- Cigarette smoking and reproductive function
Soares SR Melo MA
Curr Opin Obstet Gynaecol, 20(3):281-291, 2008.
- Cigarette Smoking and IVF
Soares SR Melo MA
Expert Rev Obstet Gynaecol, 20: 281-291, 2008.
- Influence of paternal age on assisted reproduction outcome.
Bellver J Garrido N Remohí J Pellicer A Meseguer M
Reprod Biomed Online, 17:595-604, 2008.
- Contribution of sperm molecular features to embryo quality and assisted reproduction success.
Garrido N Remohí J Martínez-Conejero JA García-Herrero S Pellicer A Meseguer M
Reprod Biomed Online, 17:855-865, 2008.
- MUC1 in human testis and ejaculated spermatozoa and its relationship to male fertility status.
Martínez-Conejero JA Garrido N Remohí J Pellicer A Simón C Meseguer M
Fertil Steril, 90:450-452, 2008.
- The significance of sperm DNA oxidation in embryo development and reproductive outcome in an oocyte donation program: a new model to study a male infertility prognostic factor
Meseguer M Martínez-Conejero JA O'Connor JE Pellicer A Remohí J Garrido N
Fertil Steril, 89:1191-1199, 2008.
- The effect of cancer on sperm DNA fragmentation as measured by the sperm chromatin dispersion test.
Meseguer M Santiso R Garrido N Fernandez JL
Fertil Steril, 90:225-227, 2008.
- PSA in the new millennium: a powerful predictor of prostate cancer prognosis and radical prostatectomy outcomes--results from the SEARCH database
Freedland SJ Hotaling J Fitzsimons NJ Presti JC Jr Kane CJ Terris MK Aronson WJ Amling CL
Eur Urol, 53(4), 758-64; discussion 765-6, 2008.
- The significance of sperm DNA oxidation in embryo development and reproductive outcome in an oocyte donation program: a new model to study a male infertility prognostic factor.
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Fertil Steril, 89:1191-1199, 2008.
- Male age negatively impacts embryo development and reproductive outcome in donor oocyte ART cycles.
Scott RT Elkind-Hirsch KE Miller BT Miller KA Frattarelli JL
Fertil Steril, 90: 97- 103, 2008.
- Light exposure and sperm nuclear DNA damage in ICSI Procedures
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Drug Metab Lett, 1:121-126, 2007.
- Sperm selection by swim-up in terms of deoxyribonucleic acid fragmentation as measured by the sperm chromatin dispersion test is altered in heavy smokers.
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- Age adjusted prostate specific antigen and prostate specific antigen velocity cut points in prostate cancer screening.
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J Urol, 177(2), 499-503; discussion 503-4, 2007.
- Prostate-specific antigen (PSA) and PSA velocity for prostate cancer detection in men aged <50 years.
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BJU Int, 99(4), 753-7, 2007.
- ¿Existe relación entre el riesgo ocupacional y la calidad seminal?.
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Conductores profesionales y agricultores. Revista Iberoamericana de fertilidad.vol 23 nº3 Mayo-Junio 2006.185-187.
- E.coli multiresistant meningitis after transrectal prostate biopsy.
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- Stem cells and fertility: what does the future hold?
Kayisli UA Seli E
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- Sperm cryopreservation in oncological patients: a 14-year follow-up study.
Meseguer M Molina N García-Velasco JA Remohí J Pellicer A Garrido N
Fertil Steril. 85:640-5, 2006.
- Use of washed sperm for assisted reproduction in HIV-positive males without checking viral absence. A risky business
Garrido N Meseguer M
Hum Reprod, 21:567-568, 2006.
- Interpretation of sperm morphology analysis in gynecological practice for infertility.
Garrido N Meseguer M Pellicer A
Expert Rev Obstet Gynecol, 1:7-9, 2006.
- The effectiveness of modified sperm washes in severely oligoasthenozoospermic men infected with human immunodeficiency and hepatitis C viruses.
Garrido N Remohí J Pellicer A Meseguer M
Fertil Steril, 86:1544-1546, 2006.
- Effect of sperm glutathione peroxidases 1 and 4 on embryo asymmetry and blastocyst quality in oocyte donation cycles.
Meseguer M Delossantos M Simón C Pellicer A Remohí J Garrido N
Fertil Steril, 86:1376-1385, 2006
- Value of the sperm deoxyribonucleic acid fragmentation level, as measured by the sperm chromatin dispersion test, in the outcome of in vitro fertilization and intracytoplasmic sperm injection.
Muriel L Garrido N Fernández JL Remohí J Pellicer A De Los Santos MJ Meseguer M
Fertil Steril, 85:371-383, 2006.
- Aumento de la fragmentación del ADN espermático en los fumadores tras la capacitación mediante swim-up.
Viloria T Garrido N Fernández JL Remohí J Pellicer A Muriel L Meseguer M
ASEBIR (2):15-21, 2006
- De la fragmentación del DNA espermático en los fumadores tras la capacitación mediante swim-up.
Viloria T Garrido N Fernandez J Remohí J Pellicer A Muriel L Meseguer M
ASEBIR, 1:15-21, 2006.
- Quality specifications for seminal parameters on the state of the ART.
Castilla JA Morancho-Zaragoza J Aguilar J Prats-Gimenez R Gonzalvo MC Fernández-Pardo E Alvarez C Calafell R Martinez L
Hum. Reprod; 20(9): 2573-8, 2005.
- The significance of sperm nuclear DNA strand breaks on reproductive outcome.
Spano M Seli E Bizarro D Manicardi GC Sakkas D
Curr Opin Obstet Gynecol 17(3):255-60, 2005.
- Spermatozoal nuclear determinants of reproductive outcome: implications on ART.
Seli E Sakkas D
Hum Reprod Update, 11:337-49, 2005.
- Semen characteristics in human immunodeficiency virus (HIV)- and hepatitis C (HCV)-seropositive males: predictors of the success of viral removal after sperm washing
Garrido N Meseguer M Remohí J Simón C Pellicer A
Hum Reprod, 20:1028-1034, 2005.
- Value of the sperm chromatin dispersion test in predicting pregnancy outcome in intrauterine insemination: a blind prospective study.
Muriel L Meseguer M Fernández JL Alvarez J Remohí J Remohí J Pellicer A Garrido N
Hum Reprod, 21:738-744, 2005.
- Smoking habits of parents and male: female ratio in spermatozoa and preimplantation embryos.
Viloria T Rubio MC Rodrigo L Calderon G Mercader A Mateu E Meseguer M Remohí J Pellicer A
Hum Reprod, 20:2517-2522, 2005.
- Eyaculación retrógrada e inseminación artificial, apropósito de un caso.
Padilla M Vega B Nieto MA Guillén V Sánchez V Domingo J García-Velasco JA
Revista Iberoamericana de Fertilidad y Reproducción XXV Congreso Nacional de la SEF, 2004.
- Report of the results of a 2 year programme of sperm wash and ICSI treatment for human immunodeficiency virus and hepatitis C virus serodiscordant couples.
Garrido N Meseguer M Bellver J Remohí J Simón C Pellicer A
Hum Reprod, 19:2581-6, 2004.
- Reproductive issues for persons with HIV.
Garrido N Meseguer M Bellver J
Am J Obstet Gynecol; 190:1489, 2004.
- BMI--the fragility of fertility.
Bellver J Bosch E Pellicer A
Fertil Steril, 81:727, 2004.
- Células madre espermatogonias.
Aguilar J Castilla JA Ortiz A González E Ortiz-Galisteo JR Peralta L Mendoza N Maldonado V Fontes J Martínez L
Rev Int Androl; 2:54-9, 2004.
- “Control de calidad en el estudio espermático”.
Castilla JA Alvarez C Magán R González E Ortiz A Ortiz-Galisteo JR Aguilar J Vergara F Ramírez JP Yoldi A Fernández A
2004.
- The extent of nuclear DNA damage in ejaculated spermatozoa impacts on blastocyst development after IVF.
Seli E Gardner DK Schoolcraft WB Moffatt O Sakkas D
Fertil Steril 82:378-83, 2004.
- The presence of abnormal spermatozoa in the ejaculate: Did apoptosis fail?
Sakkas D Seli E Manicardi GC Nijs M Ombelet W Bizzaro D
Hum Fertil 7:99-103, 2004.
- Relationship among standard semen parameters, glutathione peroxidase/glutathione reductase activity, and mRNA expression and reduced glutathione content in ejaculated spermatozoa from fertile and infe
Garrido N Meseguer M Alvarez J Simón C Pellicer A Remohí J
Fertil Steril, 82:1059-1066, 2004.
- Assisted reproduction in hiv and hcv infected men of serodiscordant couples.
Garrido N Meseguer M Simón C Pellicer A Remohí J
Arch Androl, 50:105-111, 2004.
- Ca+2 and cholesterol and mitochondrial activity in sperm from fertile and infertile men.
Meseguer M Garrido N Martínez-Conejero JA Simón C Pellicer A Remohí J
Fertil Steril, 82:S178, 2004
- Testicular Sperm Extraction (TESE) and Intracytoplasmic Sperm Injection (ICSI) in Hypogonadotropic Hypogonadism with Persistent Azoospermia After Hormonal Therapy.
Meseguer M Garrido N Remohí J Pellicer A Gil-Salom M
J Assist Reprod Genet, 21:91-94, 2004.
- Concentration of Glutathione and Expression of Glutathione Peroxidases 1 and 4 in Fresh Sperm Provide a Forecast of the Outcome of Cryopreservation of Human Spermatozoa
Meseguer M Garrido N Simón C Pellicer A Remohí J
J Androl, 25:773-780, 2004.
- Affecting the Results in a Program of Artificial Insemination With Donor Sperm. A 12-year Retrospective Review of More Than 1800 Cycles.
Zuzuarregui JL Meseguer M Garrido N Simón C Pellicer A Remohí J Parameters
Parameters J Assist Reprod Genet, 21:109-118, 2004.
- Abnormal spermatozoa in the ejaculate: abortive apoptosis and faulty nuclear remodeling during spermatogenesis.
Sakkas D Seli E Bizzaro D Tarozzi N Manicardi GC
Reprod Biomed Online 7:35-9, 2003.
- Parámetros que afectan a los resultados de la inseminación artificial con semen de donante.
Zuzuarregui JL Garrido N Meseguer M Simón C Pellicer A Remohí J
Revista Iberoamericana. de Fertilidad. 19:387-397, 2003.
- Testicular sperm extraction (TESE) and ICSI in patients with permanent azoospermia after chemotherapy.
Meseguer M
Hum Reprod, 18:1281-1285, 2003
- Human immunodeficiency virus (HIV) and Hepatitis C virus (HCV) presence in washed semen: are they absent or present although non-infective.
Meseguer M Garrido N
ART and Science Clave, 3: 10-12, 2003.
- Modulation of the immune system by sex steroids.
Seli E Arici A
Inf Reprod Med Clin N Am 13:19-48, 2002.
- Sex steroids and the immune system.
Seli E Arici A
Immunol Allergy Clin N Am 22(3): 407-433, 2002.
- Testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI) results in secondary azoospermic patients after chemotherapy.
Garrido N Meseguer M Gil-Salom M Simón C Remohí J Pellicer A
Fertil Steril, 78:S189-S190, 2002.
- Comparison of polymerase chain reaction–dependent methods for determining the presence of human immunodeficiency virus and hepatitis C virus in washed sperm.
Meseguer M Garrido N Gimeno C Remohí J Simón C Pellicer A
Fertil Steril, 78:1199-1202, 2002
- Factores influyentes en los resultados de la congelación y descongelación del semen humano.
Garrido N Meseguer M Simón C Pellicer A Remohí J
ASEBIR 7: 21-27, 2002.
- Análise do DNA do espermatozóide humano por citometria de fluxo (CF)
Garrido N Meseguer M Soares SR Simón C Pellicer A Remohí J
Reproduçao e Climaterio 2002.
- Erectile dysfunction after radical prostatectomy: hemodynamic profiles and their correlation with the recovery of erectile function
Mulhall JP Slovick R Hotaling J Aviv N Valenzuela R Waters WB Flanigan RC
J Urol, 167(3), 1371-5, 2002.
- Factor Masculino y. Técnicas de Reproducción Asistida.
Garrido N Meseguer M Gámiz P Simón C Pellicer A Remohí J
ASEBIR, 7: 10-24, 2002.
- Acrocentric chromosome disomy is increased in spermatozoa from fathers of Turner syndrome patients
Soares SR Vidal F Bosch M Martínez-Pasarell O , Nogués C Egozcue J Templado C
Hum Genet, 108:499-503, 2001
- Numerical chromosome abnormalities in the spermatozoa of the fathers of children with trisomy 21 of paternal origin: generalised tendency to meiotic non-disjunction.
Soares SR Templado C Blanco J Egozcue J Vidal F
Hum Genet, 108:134-39, 2001.
- ¿Es segura la utilización del semen de donante? Seguimiento de enfermedades infecciosas y desórdenes hereditarios en la población de donantes de semen y el programa de IAD; experiencia de 10 años
Meseguer M Garrido N Simón C Pellicer A Remohí J
Actualidad Andrológica, 9: 61-67, 2001.
- Detección del virus de la Hepatitis C en semen lavado de varones seropositivos para su posterior uso en reproducción asistida: resultados preliminares.
Garrido N Meseguer M Simón C Pellicer A Remohí J
Actualidad Andrológic, 9:56-60, 2001
- Indicaciones clínicas de la microinyección intracitoplasmática de espermatozoides.
Vidal C Romero J Rubio C Pérez-Cano I Ruiz A Navarro J Simón C Pellicer A Remohí J
Cienc Ginecol, 4:177.184, 2000.
- Chronology of venous leak development following radical prostatectomy.
Hotaling J Mulhall JP
J Urol, 16(4), 1055A, 1999.
- Virtual Reality Training for the Diagnosis of Prostate Cancer.
Burdea G Patounakis G Popescu V Weiss RE
VRAIS '98 Proceedings of the Virtual Reality Annual International Symposium, 190-7. 1998.
- Pregnancy after recovery of five testicular sperm cell cryopreserved under empty zona pellucida.
Cohen J Reing A Garrisi GJ Bar-Chama N Scott RT
In Vitro Fertilization and Assisted Reproduction, eds V Gomel and PCK Leung, Monteziore Editore, Bolgna, Italy, 105-10. 1997.
- Intraobserver, interobserver variation of sperm critical morphology: comparison of examiner and computer-assisted analysis.
Hofmann GE Santilli BA Kindig S Scott RT Johnson CA
Fertil Steril, 65:1021-5, 1996.
- Four novel germline mutations of the APC gene.
Wells D Chapman P Landgrebe JC Tsioupra K Delhanty JDA
Hum Mutat, 8:193–195, 1996.
- Measures of Association - Smoking and Fecundity.
Sharara FI Scott RT
Fertil Steril, 63:1350-1, 1995.
- Penetration of human spermatozoa through the zona pellucida of non-viable human oocytes.
Lanzendorf SE Oehninger S Scott RT Whitelock SR Hodgen GD
J Soc Gynecol Invest, 1:69-73, 1994.
- The assisted reproductive technologies in the treatment of male factor infertility.
Scott RT Navot D
Management of Impotence and Infertility, edited by ED Whitehead and HM Nagler, Williams and Wilkins, Baltimore, MD, 321-38. 1994.
- Germline rearrangement of MCC and APC detected by pulsed field gel electrophoresis and fluorescent in situ hybridization.
Gayther SA Wells D Gulati K Chapman P Burn J Delhanty JDA
Ann Hum Genet, 57:169–178, 1993.
- Hemizona assay: Assessment of human spermatozoa dysfunction and its correlation with in vitro fertilization results.
Oehninger S Scott RT Muasher SJ Coddington CC Acosta AA Hodgen GD
Advances in Assisted Reproductive Technologies, Edited by S Mashiach, Z Ben-Rafael, N Laufer and J Schenker. New York, Plenum Press, 515-24. 1990.
- Role of spermatozoa cryopreservation in assisted reproduction.
Mahony MC Morshedi M Scott RT De Villiers A Erasmus E
Human Spermatozoa in Assisted Reproduction, eds Acosta AA, Swanson RJ, Ackerman SB, Kruger TF, van Zyl JA, Menkveld R. Williams & Wilkins, 310. 1990.
- Spermatozoa motile fraction separation.
Kruger TF Menkveld R Scott RT Jeyendran RS Zaneveld LJD Windt ML
Human Spermatozoa in Assisted Reproduction, eds Acosta AA, Swanson RJ, Ackerman SB, Kruger TF, van Zyl JA, Menkveld R. Williams & Williams,181. 1990.
- Critical assessment of sperm morphology before and after double swim-up preparation for in vitro fertilization.
Scott RT Oehninger SC Menkveld R Veeck LL Acosta AA
Arch Androl, 23:125, 1989.
- Hemizona assay (HZA): Assessment of sperm dysfunction and prediction of in vitro fertilization (IVF) outcome.
Oehninger SC Coddington CC Scott RT Franken D acosta AA Hodgen GD.
Fertil Steril, 51:665, 1989.
- Assisted reproduction in the diagnosis and treatment of the male factor.
Acosta AA Oehninger SC Morshedi M Swanson RJ Scott RT Irianni F
Obstet Gynecol Surv, 44:1, 1989.
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