Male fertility
Male factor is solely responsible for fertility issues in 20% of couples and contributes to an additional 30-40%. The semen analysis has been the benchmark of male fertility assessment for many decades, however wide variability in counts, motility and morphology contribute to the enigma of determining who benefits from fertility treatments including intra-uterine insemination and in-vitro fertilization with or without intra-cytoplasmic sperm injection.
More recently, delving in the world of DNA fragmentation has fueled the search for additional sperm quality parameters. Cutting edge questions are emerging including application of microfluidics devices for sperm isolation and epigenetic determinants of sperm quality and impact on offspring.
Investigators working in this area
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Publications from this area
- Sperm lipidic profiles differ significantly between ejaculates resulting in pregnancy or not following intracytoplasmic sperm injection.
Rivera R Garrido N Sota N Meseguer M Remohí J Dominguez F
J Assist Reprod Genet. 2018 Aug 14. doi: 10.1007/s10815-018-1284-4. [Epub ahead of print]
- One Plus One Is Better Than Two: Cumulative Reproductive Outcomes Are Better after Two Elective Single Blastocyst Embryo Transfers Compared to OneDouble Blastocyst Embryo Transfer.
Mehta VP Patel JA Gupta RH Shah SI Banker MR
J Hum Reprod Sci. 2018 Apr-Jun;11(2):161-168. doi: 10.4103/jhrs.JHRS_117_17.
- Veratridine-sensitive Na+ channels regulate human sperm fertilization capacity.
Candenas L Pinto FM Cejudo Román A González-Ravina C Fernandez-Sanchez M Pérez-Hernández Irazusta J Subirán N
https://www.ncbi.nlm.nih.gov/pubmed/28246628
- Total urokinase-type plasminogen activator (uPA) levels in seminal plasma are associated with positive assisted reproductive technology outcomes.
Martinez-Soto JC Landeras J Molla M Mondejar I Nicolas M Fernández-Olmedilla L Trabalón M Coy P Gadea J
J Assist Reprod Genet. 2018 Mar 23. doi: 10.1007/s10815-018-1164-y. [Epub ahead of print]
- Effect of Body Mass Index on the Outcome of In-Vitro Fertilization/Intracytoplasmic Sperm Injection in Women.
Banker M Sorathiya D Shah S
J Hum Reprod Sci. 2017 Jan-Mar;10(1):37-43. doi: 10.4103/jhrs.JHRS_75_16.
- What the human sperm methylome tells us.
Camprubí C Cigliano RA Salas-Huetos A Garrido N Blanco J.
Epigenomics. 2017 Sep 7. doi: 10.2217/epi-2017-0049. [Epub ahead of print]
- Spermatozoa with numerical chromosomal abnormalities are more prone to be retained by Annexin V-MACS columns.
Esbert M Godo A Soares SR Florensa M Amorós D Ballesteros A Vidal F
Andrology. 2017 Jun 14. doi: 10.1111/andr.12376. [Epub ahead of print]
- Use of testicular sperm for intracytoplasmic sperm injection in men with high sperm DNA fragmentation: a SWOT analysis.
Esteves SC Roque M Garrido N
Asian J Androl. 2017 Apr 18. doi: 10.4103/aja.aja_7_17. [Epub ahead of print]
- Reproductive outcomes of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with high levels of DNA fragmentation in semen: systematic review and meta-analysis.
Esteves SC Roque M Bradley CK Garrido N
Fertil Steril. 2017 Sep;108(3):456-467.e1. doi: 10.1016/j.fertnstert.2017.06.018.
- Long-awaited long-term follow-up of reproductive parameters in female offspring conceived with the use of intracytoplasmic sperm injection.
Franasiak JM
Fertil Steril. 2017 Apr;107(4):908-909. doi: 10.1016/j.fertnstert.2017.02.111. Epub 2017 Mar 11. No abstract available.
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Presentations from this area
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Tiegs AW Landis J Garrido N Scott RT Hotaling J Total motile sperm count trend over time across two continents: evaluation of semen analyses from 119,972 infertile men Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ASRM 2018
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Tiegs W Tao X Landis J Rajchel J Bedard JL Seli E Wells D Fragouli E Scott RT
Evaluation of sperm mitochondrial dna copy number as a predictor of in vitro fertilization/intracytoplasmic sperm injection (ivf/icsi) cycle outcomes in a large infertile population
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Esbert M Soares SR Pacheco A Ballesteros A Florensa M Meseguer M
Human zygotes respond to sperm dna damage by delaying embryonic development
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Selles E Hernandez-Vargas P Garrido N Vilella F Perez-Cano I Muñoz M
Looking for molecular biomarkers of cryodamage in donors semen
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Agudo D
Sperm quality can affect the embryo kinetic and the embryo development
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Staicu FD Martinez-Soto JC Matas C Protein kinase A modulation by nitric oxide during human sperm capacitation Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
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Rivera R Sota N Meseguer M Dominguez F Remohí J Garrido N
Differential sperm proteomic profile between sperm samples achieving pregnancy or not in intracytoplasmic sperm injection (ICSI) cycles in oocyte donation program
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Gianzo M Urizar-Arenaza I Muñoa-Hoyos I Larreategui Z Irazusta J Subiran N
Human sperm aminopeptidase N is related to embryo development and viability during ART
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Rivera Egea R Sota N Meseguer M Dominguez F Remohí J Garrido N
Differential sperm proteomic profile between sperm samples achieving pregnancy or not in intracytoplasmic sperm injection (ICSI) cycles in oocyte donation program
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Esbert M Garrido N Ballesteros A Giménez Sanz A Florensa M
Predictors of positive sperm retrieval in azoospermic
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Alegre L Garrido N Munoz M De los Santos M Remohí J Meseguer M Sperm selection with hyaluronic acid (PICSI) improves LBR in IVF treatments Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2017
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Garcia-Laez V Castello D Gabrielsen A Meseguer M
Clinical validation of a home test kit for semen quality analysis; comparison with gold standard i.e. conventional sperm counting
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Martinez Morales M Meseguer M Perez-Cano I Leon G Gadea B Roldan M Hernandez-Vargas P Galindo N Legidos V Munoz M
Does the seminal cryopreservation influence in embryonic kinetics and clinical results?
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Morin SJ Juneau CR Neal SA Scott RT Hotaling J
Total motile sperm count is negatively correlated with fertilization rate but not blastulation euploidy or implantation in ICSI cycles
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Rivera Egea R Sota N Meseguer M Dominguez F Remohí J Garrido N
Differential sperm proteomic profile between sperm samples achieving pregnancy or not in intracytoplasmic sperm injection (ICSI) cycles in oocyte donation program
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Romany L Rivera Egea R Meseguer M Aparicio-Ruiz B Remohí J Garrido N
Magnetic activated sorting selection (MACS) of non-apoptotic sperm (NAS) improves ongoing pregnancy rates in homologous intrauterine insemination (IUI)
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Dahiya M Bhatia M Egbert S A systematic review and narrative report of the profound psycho-socio-cultural consequences of the growing burden of infertility in developing countries Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017
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Gianzo M Larreategui Z Muñoa-Hoyos I Urizar-Arenaza I Irazusta J Subiran N
The (Pro)renin receptor is expressed in human sperm cells and is related to sperm quality and embryo development
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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González-Ravina C Cruz M Rubio C Fernández-Sánchez M Oquiñena E Ferrando R Requena A
Polymorphic chromosome variants, human inversions, and their functional consequences in male infertility
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Sánchez M Pacheco A Cruz M Requena A
Assessment of sperm ploidy status by flow cytommetry correlates to embryo quality
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology