Reproductive disorders
Long before cell biology and molecular genetics exploded onto the scene of infertility investigation, reproductive endocrine disorders have been a topic of much examination and exploration. Disorders of hypothalamic, pituitary function, and metabolic derangements contribute to this broad field and include common everyday disorders from thyroid disease and PCOS to infrequently encountered genetic mutations encoding for rare diseases. Fibroids and endometriosis are also associated with high morbidity.
Current investigation includes the search of molecular determinants of pathogenesis with the intent of developing targeted therapies.
Investigators working in this area
Read more
Publications from this area
- Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure.
Sebastian-Leon P Garrido N Remohí J Pellicer A Diaz-Gimeno P
Hum Reprod. 2018 Feb 14. doi: 10.1093/humrep/dey023. [Epub ahead of print]
- Evaluation of PAI-1 in endometriosis using a homologous immunocompetent mouse model.
A Buigues Ferrero H Martinez J Pellicer N Pellicer A Gómez R
Biol Reprod. 2018 Mar 6. doi: 10.1093/biolre/ioy057. [Epub ahead of print]
- Infertility Stress in Couples Undergoing Intrauterine Insemination and In Vitro Fertilization Treatments.
Awtani M Mathur K Shah S Banker M
J Hum Reprod Sci. 2017 Jul-Sep;10(3):221-225. doi: 10.4103/jhrs.JHRS_39_17
- Data sharing requirements: perspectives from three authors.
Barnhart KT Legro RS Scott RT
Fertil Steril. 2018 Jan;109(1):44-47. doi: 10.1016/j.fertnstert.2017.11.034.
- The effect of low-dose ovarian stimulation with HMG plus progesterone on pregnancy outcome in women with history of recurrent pregnancy loss and secondary infertility: a retrospective cohort study.
Coccia ME Rizzello F Cozzolino M Turillazzi V Capezzuoli T
Gynecol Endocrinol. 2018 Feb 12:1-4. doi: 10.1080/09513590.2017.1416463. [Epub ahead of print]
- Evaluation of a Possible Association between estradiol and progesterone levels and ectopic pregnancy in low risk women undergoing IVF/ICSI
Elkin Muñoz Miralles F Aguilar J Muñoz L Remohí J Garrido N
SM Journal of Gynecology and Obstetrics
- Dysregulated genes and their functional pathways in luteinized granulosa cells from PCOS patients after Cabergoline-treatment.
Ferrero H Diaz-Gimeno P Sebastian-Leon P Faus A Gómez R Pellicer A
Reproduction. 2018 Feb 9. pii: REP-18-0027. doi: 10.1530/REP-18-0027. [Epub ahead of print]
- A new predictive parameter for embryo transfer success, but a path forward is needed to implement it in technique training path forward needed to implement in technique training.
Franasiak J
Fertil Steril. 2018 Jan 11. pii: S0015-0282(17)32155-6. doi: 10.1016/j.fertnstert.2017.12.014. [Epub ahead of print] No abstract available.
- The Status of Genetic Screening in Recurrent Pregnancy Loss.
Kaser DJ
Obstet Gynecol Clin North Am. 2018 Mar;45(1):143-154. doi: 10.1016/j.ogc.2017.10.007. Review.
- Luteal phase serum progesterone levels after GnRH-agonist trigger - how low is still high enough for an ongoing pregnancy?
Lawrenz B Samir S Melado Vilades L Ruiz F Fatemi H
Gynecol Endocrinol. 2018 Mar;34(3):195-198. doi: 10.1080/09513590.2017.1391204. Epub 2017 Oct 16.
Read more
Presentations from this area
-
Beltran D Vásquez V De Los Santos MJ Do the environmental pollutants affect the mitochondrial content of human embryos? Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2017
-
Dougherty MP Morin SJ Doherty L Bohrer M Leary S Scott RT Goodman L
Surgical management of complete uterine/vaginal septum with duplication of the cervix
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
-
Goodman L Khan Z Franasiak JM Juneau CR Morin SJ Neal SA Scott RT Goldberg JM
Current surgical experience and deficits in reproductive endocrinology and infertility training across fellowships in the United States
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
-
Goodman L Yoo N Pfeifer S Scott RT Shah D
Efficacy of an intensive "surgical boot camp" on laparoscopic suturing performance among reproductive endocrinology and infertility (REI) fellows
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
-
Kim JG Juneau CR Landis J Morin SJ Neal SA Scott RT
ABC trial: appraisal of body content how percent body fat (%BF) compares to body mass index (BMI) in evaluating infertile couples
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
-
Metzgar TL Whitehead CV Lopes CF Rana B Juneau CR Morin SJ Werner MD Scott RT
Does body mass index (BMI) impact the likelihood of a subject participating in a research study focused on body composition?
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
-
Cerrillo M Cruz M Ferrando R García Velasco JA Freeze-all strategy in endometriosis patients - a new indication? Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017
-
Corachán A Ferrero H Aguilar A García N Monleón J Faus A Galiano D Cervelló I Pellicer A
Vitamin D can inhibit proliferation of uterine fibroid cells in vitro through the Wnt/?-Catenin signalling pathway
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
-
García N Aguilar A Corachán A Monleón J Ferrero H Galiano D Navarro AT Cervelló I Pellicer A
In vitro proliferation of uterine fibroids is related with vitamin D receptor and patient´s age
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
-
Matorras R Exposito A Larreategui Z Lainz L Quintana F Mendoza R Ferrando M Aranburu L Ruiz Larrea MB Ruiz Sanz JI
Obese women have a different polunsaturated fatty acid pattern in their oocytes
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
-
Balaguer N Moreno I Herrero M González-Montfort M Simón C Vilella F Maternal MiR-30d deficiency is associated with defects in endometrial receptivity, embryonic implantation and fetal development Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
SRI 2017
-
Díaz-Gimeno P Ruiz-Alonso M Sebastián-León P Singh V Pellicer A Valbuena D Simón C
Improvement of the endometrial receptivity signature reveals a possible maternal origin of biochemical pregnancies
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
-
Garrido-Gómez T Dominguez F Quiñonero A Díaz-Gimeno P Kapidzic M Gormley M Ona K Pablo Padilla Genbacev O Perales A Fisher S Simón C
Severe preeclampsia is associated with resistance to decidualization
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
-
Salsano S Quiñonero A Pérez S Simón C Domínguez F
Non Classical Progesterone Receptor and SERPINE1mRNA (PGRMC1) Binding Protein (SERBP1) Interaction Influences the Human Decidualization Process
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation