Reproductive disorders
Long before cell biology and molecular genetics exploded onto the scene of infertility investigation, reproductive endocrine disorders have been a topic of much examination and exploration. Disorders of hypothalamic, pituitary function, and metabolic derangements contribute to this broad field and include common everyday disorders from thyroid disease and PCOS to infrequently encountered genetic mutations encoding for rare diseases. Fibroids and endometriosis are also associated with high morbidity.
Current investigation includes the search of molecular determinants of pathogenesis with the intent of developing targeted therapies.
Investigators working in this area
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Publications from this area
- Introduction: IVF's 40th world birthday.
Niederberger C Pellicer A
Fertil Steril. 2018 Jul 1;110(1):4. doi: 10.1016/j.fertnstert.2018.05.017.
- Is the ovarian reserve influenced by vitamin D deficiency and the dress code in an infertile Iranian population?
Arefi S Khalili G Iranmanesh H Farifteh F Hosseini A Fatemi H Lawrenz B
J Ovarian Res. 2018 Jul 24;11(1):62. doi: 10.1186/s13048-018-0435-7
- Forty years of IVF.
Niederberger C Pellicer A Cohen J Gardner DK Palermo GD Neill CL Chow S Rosenwaks Z Cobo A Swain JE Schoolcraft WB Frydman Bishop LA Aharon D Gordon C New E Decherney A Tan SL Paulson RJ Goldfarb JM Brännström M Donnez JSilber S Dolmans MM Simpson JL Handyside AH Munné S Eguizabal C Montserrat N Izpisua Belmonte JC Trounson A Simon C Tulandi T Giudice LC Norman RJ Hsueh AJ Sun Y Laufer N Kochman R Eldar-Geva T Lunenfeld B Ezcurra D Hooghe T Fauser BC Tarlatzis B Meldrum D Casper R Fatemi H Devroey P Galliano D
Fertil Steril. 2018 Jul 15;110(2):185-324.e5. doi: 10.1016/j.fertnstert.2018.06.005. Review.
- Immune testing and treatment: still an open debate.
Alecsandru D García-Velasco JA
Hum Reprod. 2015 Aug;30(8):1994. doi: 10.1093/humrep/dev140. Epub 2015 Jun 3. No abstract available
- Human leukocyte antigen DQ2/DQ8 positivity in women with history of still birth.
Cozzolino M Serena C Calabró AS Savi E Rambaldi MP Simeone S Ottanelli S Mello G Rombolá G Troiano G Nante N Vannuccini S Mecacci F Petraglia F
Am J Reprod Immunol. 2018 Aug 19:e13038. doi: 10.1111/aji.13038. [Epub ahead of print]
- Reply to Liu et al.: Decidualization defect in severe preeclampsia.
Garrido-Gomez T Fisher SJ Simón C
Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7656-E7657. doi: 10.1073/pnas.1802916115. Epub 2018 Aug 1. No abstract available.
- Evaluation of sexual function in women with deep infiltrating endometriosis.
Cozzolino M Magro-Malosso ER Tofani L Coccia ME
Sex Reprod Healthc. 2018 Jun;16:6-9. doi: 10.1016/j.srhc.2017.12.005. Epub 2018 Jan 3.
- Celiac disease is not more prevalent in patients undergoing in vitro fertilization and does not affect reproductive outcomes with or without treatment: a large prospective cohort study.
Juneau CR Franasiak JM Goodman L Marin D Scott K Morin SJ Neal SA Juneau JE Scott RT
Fertil Steril. 2018 Aug;110(3):437-442. doi: 10.1016/j.fertnstert.2018.03.030.
- One Plus One Is Better Than Two: Cumulative Reproductive Outcomes Are Better after Two Elective Single Blastocyst Embryo Transfers Compared to OneDouble Blastocyst Embryo Transfer.
Mehta VP Patel JA Gupta RH Shah SI Banker MR
J Hum Reprod Sci. 2018 Apr-Jun;11(2):161-168. doi: 10.4103/jhrs.JHRS_117_17.
- Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure.
Sebastian-Leon P Garrido N Remohí J Pellicer A Diaz-Gimeno P
Hum Reprod. 2018 Feb 14. doi: 10.1093/humrep/dey023. [Epub ahead of print]
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Presentations from this area
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Lara EE Franasiak JM Devesa-Peiro A Martin M Florensa M Lopez M Díaz-Gimeno P Pellicer A 24,25(oh)2d3: a novel accurate indicator of ovarian vitamin d status in women at reproductive age Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ASRM 2018
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Neal A Goodman LR Morin SJ Werner MD Gueye N Tiegs W Pirtea P Scott RT
Only patients with obvious adenomyosis on three-dimensional ultrasound (3d us) are at increased risk of clinical loss following frozen embryo transfer
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Wang T Babayev E Jiang Z Zhang M Esencan E Seli E
Rapamycin partially rescues oocyte dysfunction in mice deficient for mitochondrial stress response protein clpp
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Esencan Jiang Z Wang T Zhang M Bener MB Scott RT
Impaired mitochondrial stress response in cumulus cells is associated with increased apoptosis and accelerated follicular depletion
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Neal A Goodman LR Morin SJ Werner MD Gueye N Tiegs W Pirtea P Scott RT
T-shaped uterine cavity morphology as assessed by three-dimensional ultrasound (3d us) is associated with lower sustained implantation rates and higher clinical loss rates following frozen embryo
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Aruna R Banker M Patel A Priyasakthi C Krithikadevi Madhupriya A
The risk of preeclampsia in frozen thawed embryotransfers among asian population: analysis of 1862 cases conceived with icsi
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Beltran D Vásquez V De Los Santos MJ Do the environmental pollutants affect the mitochondrial content of human embryos? Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2017
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Dougherty MP Morin SJ Doherty L Bohrer M Leary S Scott RT Goodman L
Surgical management of complete uterine/vaginal septum with duplication of the cervix
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Goodman L Khan Z Franasiak JM Juneau CR Morin SJ Neal SA Scott RT Goldberg JM
Current surgical experience and deficits in reproductive endocrinology and infertility training across fellowships in the United States
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Goodman L Yoo N Pfeifer S Scott RT Shah D
Efficacy of an intensive "surgical boot camp" on laparoscopic suturing performance among reproductive endocrinology and infertility (REI) fellows
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Kim JG Juneau CR Landis J Morin SJ Neal SA Scott RT
ABC trial: appraisal of body content how percent body fat (%BF) compares to body mass index (BMI) in evaluating infertile couples
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Metzgar TL Whitehead CV Lopes CF Rana B Juneau CR Morin SJ Werner MD Scott RT
Does body mass index (BMI) impact the likelihood of a subject participating in a research study focused on body composition?
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Cerrillo M Cruz M Ferrando R García Velasco JA Freeze-all strategy in endometriosis patients - a new indication? Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017
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Corachán A Ferrero H Aguilar A García N Monleón J Faus A Galiano D Cervelló I Pellicer A
Vitamin D can inhibit proliferation of uterine fibroid cells in vitro through the Wnt/?-Catenin signalling pathway
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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García N Aguilar A Corachán A Monleón J Ferrero H Galiano D Navarro AT Cervelló I Pellicer A
In vitro proliferation of uterine fibroids is related with vitamin D receptor and patient´s age
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Matorras R Exposito A Larreategui Z Lainz L Quintana F Mendoza R Ferrando M Aranburu L Ruiz Larrea MB Ruiz Sanz JI
Obese women have a different polunsaturated fatty acid pattern in their oocytes
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Balaguer N Moreno I Herrero M González-Montfort M Simón C Vilella F Maternal MiR-30d deficiency is associated with defects in endometrial receptivity, embryonic implantation and fetal development Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
SRI 2017
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Díaz-Gimeno P Ruiz-Alonso M Sebastián-León P Singh V Pellicer A Valbuena D Simón C
Improvement of the endometrial receptivity signature reveals a possible maternal origin of biochemical pregnancies
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Garrido-Gómez T Dominguez F Quiñonero A Díaz-Gimeno P Kapidzic M Gormley M Ona K Pablo Padilla Genbacev O Perales A Fisher S Simón C
Severe preeclampsia is associated with resistance to decidualization
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Salsano S Quiñonero A Pérez S Simón C Domínguez F
Non Classical Progesterone Receptor and SERPINE1mRNA (PGRMC1) Binding Protein (SERBP1) Interaction Influences the Human Decidualization Process
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation