Reproductive disorders
Long before cell biology and molecular genetics exploded onto the scene of infertility investigation, reproductive endocrine disorders have been a topic of much examination and exploration. Disorders of hypothalamic, pituitary function, and metabolic derangements contribute to this broad field and include common everyday disorders from thyroid disease and PCOS to infrequently encountered genetic mutations encoding for rare diseases. Fibroids and endometriosis are also associated with high morbidity.
Current investigation includes the search of molecular determinants of pathogenesis with the intent of developing targeted therapies.
Investigators working in this area
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Publications from this area
- Fallopian tube endometriosis: clinical implications
Garcia-Velasco JA
Fertility and SterilityIn press, corrected proofAvailable online 24 August 2020
- A 300°IR sublingual tablet is an effective, safe treatment for house-dust-mite-induced allergic rhinitis: an international, double-blind, placebo-controlled, randomized Phase III clinical trial.
Demoly P Corren J Creticos P De Blay F Gevaert P Hellings P Kowal K Le Gall M Nenasheva N Passalacqua G Pfaar O Tortajada-Girbés M Vidal C Worm M Casale TB
J Allergy Clin Immunol. 2020 Sep 2:S0091-6749(20)31221-5. doi: 10.1016/j.jaci.2020.07.036. Online ahead of print.
- Outcome of in-vitro oocyte maturation in patients with PCOS: does phenotype have an impact?
Mackens S Pareyn S Drakopoulos P Deckers T Mostinckx L Blockeel C Segers I Verheyen G Santos-Ribeiro S Tournaye H De Vos M
Hum Reprod. 2020 Sep 20:deaa190. doi: 10.1093/humrep/deaa190. Online ahead of print.
- HMGA2 involvement in uterine leiomyomas development through angiogenesis activation.
Ferrero H
Fertil Steril. 2020 Sep 14:S0015-0282(20)30697-X. doi: 10.1016/j.fertnstert.2020.07.044. Online ahead of print.
- Is there a link between focal adenomyosis and infertility?
Garcia-Velasco JA
Fertility and SterilityIn press, corrected proofAvailable online 25 September 2020
- Impact of ABVD chemotherapy on ovarian reserve after fertility preservation in reproductive-aged women with Hodgkin lymphoma.
Policiano C Subirá J Aguilar A Monzó S Iniesta I Rubio Rubio JM
J Assist Reprod Genet. 2020 Jun 2. doi: 10.1007/s10815-020-01844-0. Online ahead of print.
- Levothyroxine and thyroid peroxidase antibodies in women with recurrent pregnancy loss.
Alecsandru D Garcia Velasco JA
Fertil Steril. 2020 Mar;113(3):546. doi: 10.1016/j.fertnstert.2019.12.016. Epub 2020 Feb 25.
- The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers.
Reig A Franasiak J Scott RT Seli E
J Assist Reprod Genet. 2020 Mar 16. doi: 10.1007/s10815-020-01739-0. [Epub ahead of print]
- The impact of endometrioma size on ovarian responsiveness.
Edgardo Somigliana Maria Cruz Palomino Marta Castiglioni Mensi L Benaglia L Vercellini P Garcia-Velasco JA
Reproductive BioMedicine OnlineIn press, journal pre-proofAvailable online 13 March 2020
- New Insights into the Anterior Complex.
Viñals F Correa F Tubau A Alonso I Serra V Herraiz I Hormazabal L Quiroz G Saint-Jean C Diaz L Zambrano B Galindo A
Fetal Diagn Ther. 2020 Jan 13:1-5. doi: 10.1159/000504980. [Epub ahead of print]
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Presentations from this area
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Chico-Sordo L Soler I Mateu-Pascual JM Córdova-Oriz I Polonio AM Marta Medrano María J Soriano Garcia-Velasco JA Varela E P-358 EFFECT OF DISTAL CANCER ON THE TELOMERIC LENGTH OF OVARIAN CORTEX CELLS Presented at 76th American Society of Reproductive Medicine Scientific Congress
ASRM2020
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Cozzolino M Garcia-Velasco JA Meseguer M Pellicer A Bellver J
O-153 OBESE WOMEN PRESENT AN INCREASED RISK OF MISCARRIAGE AFTER EUPLOID EMBRYO TRANSFER
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Esencan E Imamoglu G Cozzolino M Seli E
P-578 MITOCHONDRIAL STRESS RESPONSE GENE CLPP IS NOT REQUIRED FOR GRANULOSA CELL FUNCTION
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Cozzolino M Titus S Herraiz S Pellicer A Scott RT Seli E
P-723 TRANSCRIPTOMIC LANDSCAPE OF GRANULOSA CELLS AND PERIPHERAL BLOOD MONONUCLEAR (PBMN) CELLS IN WOMEN WITH PCOS AND POOR OVARIAN RESPONSE (POR)
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Kumar K Venturas M Dan Needleman Catherine Racowsky
P-618 MITOCHONDRIAL DNA QUANTITY AND SEQUENCE VARIATION IN HUMAN CUMULUS CELLS ARE ASSOCIATED WITH PATIENT BMI BUT NOT AGE OR ASSISTED REPRODUCTION OUTCOMES
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Meseguer M 0-164 The application of artificial oocyte activation (AOA) in patients with previous unsuccessful attempt increases the ongoing pregnancy per treatment but not per transfer, a multivariable study. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2020
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Corachán A Trejo MG Carbajo-García MC Faus A Escrig J Monleón J Pellicer A Cervelló I Ferrero H
Vitamin D as an effective treatment to reduce cell proliferation and extra cellular matrix formation in human uterine leiomyomas regardless MED12 mutation status.
Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
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Henarejos-Castillo I Aleman A Martinez Montoro B Javier Gracia F Sebastian-Leon P Remohí J Patiño A Royo P Alkorta G Diaz-Gimeno P
Clinical exome sequencing from peripheral blood reveals novel gene variants to prevent ovarian failure
Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
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Pellicer N Herraiz S Martínez RM Buigues A Gómez-Seguí I Martínez J Pellicer A
O-088 Bone marrow derived stem cells restore ovarian function and fertility in premature ovarian insufficiency women. Interim report of a randomized trial: mobilization versus ovarian injection.
Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
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Hernández-Vargas P Gadea B Lozoya V Legidos V Muñoz M
The effect of endometriosis in the chromosomal status and developmental competence of cleavage-stage embryos. Differences with embryos in the blastocyst stage
Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
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Corachán A Ferrero H Escrig J Monleón J Faus A Cervelló I Pellicer A O-208 VITAMIN D LONG-TERM TREATMENT DECREASES HUMAN UTERINE LEIOMYOMA SIZE THROUGH SPECIFIC MOLECULAR MECHANISMS IN A XENOGRAFT ANIMAL MODEL Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2019
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Marin D Tao X Sun L Scott RT
O-255 UNRAVELLING THE IMMUNOGENETICS OF PREGNANCY: PARENTAL HLA-C ALLOTYPES ARE PREDICTIVE OF PREGNANCY LOSS AFTER SINGLE EUPLOID EMBRYO TRANSFERS
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Neal SA Tao X Sun L Hanson BM Kim G Osman EK Tiegs AW Scott RT Franasiak JM
P-219 HIGH CONCORDANCE BETWEEN VAGINAL AND CERVICAL MICROBIOME ASSESSMENTS WITH INCREASING MICROBIAL DIVERSITY NEGATIVELY IMPACTS PREGNANCY OUTCOMES FOLLOWING TRANSFER OF A SINGLE EUPLOID BLASTOCYST
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Tiegs AW Osman EK Kim G Hanson BM Franasiak JM Scott RT Goodman LR
P-705 PREGNANCY OUTCOMES FOLLOWING INTRAUTERINE INSEMINATION (IUI) IN YOUNG WOMEN WITH DECREASED OVARIAN RESERVE
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Neal SA Scott RT Goodman LR
O-89 PREGNANCY OUTCOMES FOLLOWING HYSTEROSCOPIC CORRECTION OF T-SHAPED UTERI
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Klimczak AM Whitehead CR Neal SA Tiegs AW Osman EK Hanson BM Werner MD Kim G Franasiak JM Scott RT
O-41 NON-INVASIVE PRENATAL TESTING HAS ALTERED POSITIVE PREDICTIVE VALUE FOLLOWING TRANSFER OF A EUPLOID BLASTOCYST
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Bori L Del Gallego R Alegre L Meseguer M
V-6 Continuous monitoring of the embryo development: a leap towards automated systems
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Cozzolino M Vitagliano A
P-721 PROBIOTICS AND SYNBIOTICS FOR POLYCYSTIC OVARIAN SYNDROME: A SYSTEMATIC REVIEW AND META-ANALYSIS
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Alegre L Del Gallego R Bori L Muñoz M Pellicer A Meseguer M
P-415 A MASSIVE EMBRYO MORPHOKINETICS COMPARISON SYSTEM IS ABLE TO SELECT EMBRYOS WITH HIGH IMPLANTATION POTENTIAL ENHANCING SINGLE EMBRYO TRANSFER POLICY
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Cakiroglu Y Saltik A Yuceturk A Karaosmanoglu O Tayyar A Scott RT Tiras B Seli E
O-171 EFFECTS OF INTRAOVARIAN INJECTION OF AUTOLOGOUS PLATELET RICH PLASMA ON OVARIAN RESERVE AND IVF OUTCOMES IN WOMEN WITH PREMATURE OVARIAN INSUFFICIENCY
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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De Munck F Bayram A Elkhatib I Liñán A Arnanz A Lawrenz B Fatemi H P-518: Segmental insertions and monosomies are linked to developmental arrest. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ESHRE 2019
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Arnanz A De Munck N Nkuhlu A ElKhatib I Bayram A Liñan A Melado L Lawrenz B Fatemi H
O-013: Anti-Müllerian Hormone (AMH) as a quantitative and qualitative marker of euploid blastocysts.
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Rienzi L Cimadomo D Delgado A Minasi MG Fabozzi G Del Gallego R Stoppa M Bellver J Giancani A Esbert M Capalbo A Remohí J Greco E Ubaldi F Meseguer M
O-006: Time of morulation and trophectoderm quality are associated with live birth after euploid blastocyst transfer: a multicenter study
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Del Gallego R Bonilla Alegre L Bori L Peura T Azaña S Meseguer M
O-171: Embryo development detection by automated software vs. embryologist team.
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Vázquez Cubillos V Capuano F Beltran D Buendia P Insua F Garcia V Galan A De los Santos MJ
P-169: Evaluation of the effects produced by Styrene (volatile organic compound- VOC) over the human pre- embryo development.
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Margarida E Rodriguez J Wells D Bassas L Loiudice I Casas A Joumady M Guerin A Ballesteros A Fragouli E
P-743: Lack of consistency in the execution and reporting of sperm FISH poses potential problems for clinical interpretation and patient counselling
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Esbert M Soares SR Pacheco A Ballesteros A Florensa M Meseguer M Human zygotes respond to sperm dna damage by delaying embryonic development Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2018
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Alecsandru D Pacheco A Fabris A Barrio A Aparicio P García-Velasco J
Ovarian stimulation doesn’t influence the uterine immune environment in healthy infertile women
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Perez-Albal S Aparicio Ruiz B Galan Rivas A Alegre L Meseguer M
Delayed blastulation is linked with changes at early cleavage stage detected by continuous embryo monitoring
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Tejera A Alegre L Castello D Mifsud A Meseguer M
Improvement in reproductive outcome through artificial oocyte activation on fertilization failure cases: a cohort study
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Coello A Cobo A Galan A Nohales M Beltrán D Meseguer M
The ability of warmed blastocysts to re-expand and the pre-vitrification trophoectoderm grade significantly correlated with implantation
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Zhang M Bener MB Wang T Esencan E Scott RT
Impaired follicle developmentand subfertility in female mice lacking mfn2 in oocytes
Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
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Azkargorta M Escobes I Lloro I Osinalde N Corral B Exposito A Prieto B Elortza F Matorras R Differential proteomic analysis of endometrial fluid suggets increased inflammation and extracellular matrix remodeling in non-implantative IVF cycles Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
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Gianzo M Urizar-Arenaza I Muñoa-Hoyos I Larreategui Z Irazusta J Subiran N
Human sperm aminopeptidase N is related to embryo development and viability during ART
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Rivera Egea R Sota N Meseguer M Dominguez F Remohí J Garrido N
Differential sperm proteomic profile between sperm samples achieving pregnancy or not in intracytoplasmic sperm injection (ICSI) cycles in oocyte donation program
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Alegre L Palma AE Marcos JJ Albert C Del Gallego R Pellicer A Meseguer M Time-lapse technology combined with a novel automated analysis method for embryo selection; clinical validation Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2017
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Esbert M Marconetto A Reis Soares S Quera M Molina J Florensa M Ballesteros A Meseguer M
Does the blastocyst collapse respond to a biological need? The analysis of 1,952 embryos by time-lapse can give an answer
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Franasiak JM Scott RT Molina L Pellicer A
Serum vitamin D (OHD) levels are correlated with embryonic aneuploidy
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Garcia-Laez V Castello D Gabrielsen A Meseguer M
Clinical validation of a home test kit for semen quality analysis; comparison with gold standard i.e. conventional sperm counting
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Juneau CR Franasiak JM Morin SJ Werner MD Upham K Scott RT
Enmotion (embryo's natural motion): a paired randomized controlled trial demonstrating pregnancy rates are equivalent between static and dynamic culture systems
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation