Stem cells

The regenerative capacity of stem cells make them an intriguing possibility for variety of infertility related pathology.

The scientific team at IVI RMA Global has launched multiple studies in different areas of reproductive, as a result. Early data from a prospective study of patients with Asherman’s syndrome (or severe scarring of the uterine cavity) or endometrial atrophy (failed development of the uterine lining) demonstrated improved endometrial growth and reduced scar tissue after infusion with bone marrow derived stem cells. Additional studies have utilized injection of stem cells into the ovarian vasculature in an effort to reverse premature ovarian aging.

Furthermore, researchers are examining ways of isolating and culturing spermatogonial stem cells in vitro with the goal improving sperm yield in men with azoospermia.

Investigators
working in this area

Loading data

Name
Irene Cervelló, Ph.D. Laboratory Manager & Endometrial Stem Cell and Bioengineering Research Group Leader at the IVI Foundation Research Department FIVI Valencia
Sonia Herraiz, Ph.D. Ovarian Reactivation and Fertility Preservation Research Group Leader at FIVI. FIVI Valencia
Antonio Pellicer , M.D., Ph.D. Executive Chair of the Board of Directors for IVIRMA Global IVI Rome
James Hotaling, M.D. Urologist Specialist in Male Infertility and Men’s Health at RMA of new Jersey RMA New Jersey
Dagan Wells, Ph.D. Oxford Research Director Oxford Basic Research Centre
José Remohí, M.D – Ph.D. Founding Partner IVI-RMA Global IVI Valencia
Emre Seli, M.D. US Research Director RMA New Jersey
Richard T Scott, M.D.,H.C.L.D. Founding Partner IVIRMA Global RMA New Jersey

Publications
from this area

Loading data

Name
Single intraovarian dose of stem cell- and platelet-secreted factors mitigates age-related ovarian infertility in a murine model. María Marchante, Anna Buigues, Noelia Ramirez-Martin, Jessica Martinez, Nuria Pellicer, Antonio Pellicer, Sonia Herraiz American Journal of Obstetrics and GynecologyAvailable online 24 January 2023. 2023 doi:
Pathways and factors regulated by bone marrow-derived stem cells in human ovarian tissue. Buigues, A, Diaz-Gimeno, P, Sebastian-Leon, P, Pellegrini, L, Pellicer, N, Pellicer, A, Herraiz, S Fertil Steril. May. 2021 doi: 10.1016/j.fertnstert.2021.04.009
Translating Regenerative Medicine to the Clinic. Advances in Translational Medicine. Regenerative Medicine and Tissue Engineering in Reproductive Medicine: Future Clinical Applications in Human Infertility. Cervello, I, Medrano, JV, Simon, C, 2016 doi:
Human CD133(+) bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome Cervello, I, Gil-Sanchis, C, Santamaria, X, Cabanillas, S, Diaz, A, Faus, A, Pellicer, A, Simon, C, Fertil Steril. Dec. 2015 doi: 10.1016/j.fertnstert.2015.08.032
Cyclin E1 plays a key role in balancing between totipotency and differentiation in human embryonic cells. Krivega, MV, Geens, M, Heindryckx, B, Santos-Ribeiro, S, Tournaye, H, Van, de, Velde, H, Mol Hum Reprod. 2015 doi:
Global deoxyribonucleic acid methylation: a window into the spermatogonial stem cell's reproductive potential. Hotaling, J M, Fertil Steril. 2015 doi:
Germ line development: lessons learned from pluripotent stem cells Martinez-Arroyo, A M, Medrano, J V, Remohi, J, Simon, C, Curr Opin Genet Dev. Oct. 2014 doi: 10.1016/j.gde.2014.09.011
Autocrine regulation of human sperm motility by the met-enkephalin opioid peptide. Subiran, N, Candenas, L, Pinto, FM, Cejudo-Roman, A, Agirregoitia, E, Irazusta, J, Fertil Steril. 2012 doi:
Different telomere-length dynamics at the Inner Cell Mass versus Established Embryonic Stem (ES) cells. Varela, E, Schneider, RP, Ortega, S, Blasco, MA, Proc Natl Acad Sci USA. 2011 doi:
Stem cells and fertility: what does the future hold? Kayisli, UA, Seli, E, Curr Opin Obstet Gynecol. 2006 doi:

Single intraovarian dose of stem cell- and platelet-secreted factors mitigates age-related ovarian infertility in a murine model.
María Marchante, Anna Buigues, Noelia Ramirez-Martin, Jessica Martinez, Nuria Pellicer, Antonio Pellicer, Sonia Herraiz

American Journal of Obstetrics and GynecologyAvailable online 24 January 2023. 2023 doi:

Pathways and factors regulated by bone marrow-derived stem cells in human ovarian tissue.
Buigues, A, Diaz-Gimeno, P, Sebastian-Leon, P, Pellegrini, L, Pellicer, N, Pellicer, A, Herraiz, S

Fertil Steril. May. 2021 doi: 10.1016/j.fertnstert.2021.04.009

Translating Regenerative Medicine to the Clinic. Advances in Translational Medicine. Regenerative Medicine and Tissue Engineering in Reproductive Medicine: Future Clinical Applications in Human Infertility.
Cervello, I, Medrano, JV, Simon, C,

2016 doi:

Human CD133(+) bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome
Cervello, I, Gil-Sanchis, C, Santamaria, X, Cabanillas, S, Diaz, A, Faus, A, Pellicer, A, Simon, C,

Fertil Steril. Dec. 2015 doi: 10.1016/j.fertnstert.2015.08.032

Cyclin E1 plays a key role in balancing between totipotency and differentiation in human embryonic cells.
Krivega, MV, Geens, M, Heindryckx, B, Santos-Ribeiro, S, Tournaye, H, Van, de, Velde, H,

Mol Hum Reprod. 2015 doi:

Global deoxyribonucleic acid methylation: a window into the spermatogonial stem cell's reproductive potential.
Hotaling, J M,

Fertil Steril. 2015 doi:

Germ line development: lessons learned from pluripotent stem cells
Martinez-Arroyo, A M, Medrano, J V, Remohi, J, Simon, C,

Curr Opin Genet Dev. Oct. 2014 doi: 10.1016/j.gde.2014.09.011

Autocrine regulation of human sperm motility by the met-enkephalin opioid peptide.
Subiran, N, Candenas, L, Pinto, FM, Cejudo-Roman, A, Agirregoitia, E, Irazusta, J,

Fertil Steril. 2012 doi:

Different telomere-length dynamics at the Inner Cell Mass versus Established Embryonic Stem (ES) cells.
Varela, E, Schneider, RP, Ortega, S, Blasco, MA,

Proc Natl Acad Sci USA. 2011 doi:

Stem cells and fertility: what does the future hold?
Kayisli, UA, Seli, E,

Curr Opin Obstet Gynecol. 2006 doi:

Presentations
from this area

Loading data

Name
ESHRE 2020 Future stem cell therapies in fertility preservation of prepuberal children with cancer or genetic syndromes. Improvements in the characterization of human Spermatogonial Stem Cells. Myriam M Armendariz E Herrera L Rodriguez C Roig N Garcia-Quevedo L Vidal F Diaz-Nuñez M Prieto M Matorras R Lopez-Almaraz R Solorzano E Chuva de Sousa Lopes SM A. van Pelt8 Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
SRI 2020 T-208 Stem Cell Secreted Factors-Enriched Plasma Promotes DNA Repair and Protects Against Chemotherapy-Induced Cell Death in Ovarian Tissue Marchante M Buigues A Pellicer A Herraiz S Presented at the 67th Annual Meeting of the Society for Reproductive Investigation
ASRM 2019 P-310 Impact of different degrees of genetic mosaicism in the kinetic profile of the human embryo Ángel Martin Vidal C Rodrigo L Mercader A Rubio C Giles J Remohí J De los Santos MJ Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology P-302 CONVENTIONAL PROTOCOL VERSUS MINIMAL OVARIAN STIMULATION IN PATIENTS WITH POOR REPRODUCTIVE PROGNOSIS ACCORDING TO THE POSEIDON CRITERIA Cozzolino M Cecchino G Garrido N Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology O-74 DOES PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A) HARM EMBRYOS? NO—A MULTI-CENTER,PROSPECTIVE,BLINDED,NON-SELECTION STUDY EVALUATING THE PREDICTIVE VALUE OF AN ANEUPLOID DIAGNOSIS AND IMPACT OF BIOPSY Tiegs AW Tao X Whitehead CR Neal SA Osman EK Kim G Hanson BM Seli E Patounakis G Gutmann J Castlebaum A Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology P-417 Effect of different 6-dimethylaminopurine (6-DMAP) treatments on reversible arresting of mono and tripronuclear embryos at the pronuclear stage Grau Gonzalez-Picazo A Soler N Escribá MJ Vendrell X Viloria T Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2018 Gonadotrophin receptor polymorphisms (fshr n680s and lhcgr n312s) are not of clinical outcome and live birth in ivf cycles Pirtea P Marin D Sun L Hong K Zhan Y Tao X Scott RT Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
SRI 2018 Stem Cell-Secreted Paracrine Factors in Human Endometrial Regeneration López-Pérez N Santamaría X Díaz-Gimeno P Sebastian-Leon P Faus A Remohí J Pellicer A Simón C Cervelló I Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2017 Estimation of reproductive success according to age,number of oocytes and etiology in elective or oncological fertility preservation (FP) patients Cobo A Meseguer M Coello A Sanchez E Garcia Velasco J Remohí J Pellicer A Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology Oocyte dysmorphisms are not associated with post warming survival,fertilization and embryo development in own oocytes vitrification cycles Coello A Sanchez E Campos P Vallejo B Meseguer M Cobo A Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology Incidental diagnosis of a parental balanced reciprocal rearrangement in couples undergoing routine aneuploidy screening by targeted next generation sequencing (TNGS) Garnsey HM Eccles JM Iturriaga A Scott RT Zimmerman RS Presented at the 64th Annual Meeting of the Society for Reproductive Investigation Current surgical experience and deficits in reproductive endocrinology and infertility training across fellowships in the United States Goodman L Khan Z Franasiak JM Juneau CR Morin SJ Neal SA Scott RT Goldberg JM Presented at the 64th Annual Meeting of the Society for Reproductive Investigation Efficacy of an intensive "surgical boot camp" on laparoscopic suturing performance among reproductive endocrinology and infertility (REI) fellows Goodman L Yoo N Pfeifer S Scott RT Shah D Presented at the 64th Annual Meeting of the Society for Reproductive Investigation

ESHRE 2020

Future stem cell therapies in fertility preservation of prepuberal children with cancer or genetic syndromes. Improvements in the characterization of human Spermatogonial Stem Cells.
Myriam M Armendariz E Herrera L Rodriguez C Roig N Garcia-Quevedo L Vidal F Diaz-Nuñez M Prieto M Matorras R Lopez-Almaraz R Solorzano E Chuva de Sousa Lopes SM A. van Pelt8
Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology

SRI 2020

T-208 Stem Cell Secreted Factors-Enriched Plasma Promotes DNA Repair and Protects Against Chemotherapy-Induced Cell Death in Ovarian Tissue
Marchante M Buigues A Pellicer A Herraiz S
Presented at the 67th Annual Meeting of the Society for Reproductive Investigation

ASRM 2019

P-310 Impact of different degrees of genetic mosaicism in the kinetic profile of the human embryo
Ángel Martin Vidal C Rodrigo L Mercader A Rubio C Giles J Remohí J De los Santos MJ
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
P-302 CONVENTIONAL PROTOCOL VERSUS MINIMAL OVARIAN STIMULATION IN PATIENTS WITH POOR REPRODUCTIVE PROGNOSIS ACCORDING TO THE POSEIDON CRITERIA
Cozzolino M Cecchino G Garrido N
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
O-74 DOES PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A) HARM EMBRYOS? NO—A MULTI-CENTER,PROSPECTIVE,BLINDED,NON-SELECTION STUDY EVALUATING THE PREDICTIVE VALUE OF AN ANEUPLOID DIAGNOSIS AND IMPACT OF BIOPSY
Tiegs AW Tao X Whitehead CR Neal SA Osman EK Kim G Hanson BM Seli E Patounakis G Gutmann J Castlebaum A
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
P-417 Effect of different 6-dimethylaminopurine (6-DMAP) treatments on reversible arresting of mono and tripronuclear embryos at the pronuclear stage
Grau Gonzalez-Picazo A Soler N Escribá MJ Vendrell X Viloria T
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology

ASRM 2018

Gonadotrophin receptor polymorphisms (fshr n680s and lhcgr n312s) are not of clinical outcome and live birth in ivf cycles
Pirtea P Marin D Sun L Hong K Zhan Y Tao X Scott RT
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation

SRI 2018

Stem Cell-Secreted Paracrine Factors in Human Endometrial Regeneration
López-Pérez N Santamaría X Díaz-Gimeno P Sebastian-Leon P Faus A Remohí J Pellicer A Simón C Cervelló I
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology

ASRM 2017

Estimation of reproductive success according to age,number of oocytes and etiology in elective or oncological fertility preservation (FP) patients
Cobo A Meseguer M Coello A Sanchez E Garcia Velasco J Remohí J Pellicer A
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
Oocyte dysmorphisms are not associated with post warming survival,fertilization and embryo development in own oocytes vitrification cycles
Coello A Sanchez E Campos P Vallejo B Meseguer M Cobo A
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
Incidental diagnosis of a parental balanced reciprocal rearrangement in couples undergoing routine aneuploidy screening by targeted next generation sequencing (TNGS)
Garnsey HM Eccles JM Iturriaga A Scott RT Zimmerman RS
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
Current surgical experience and deficits in reproductive endocrinology and infertility training across fellowships in the United States
Goodman L Khan Z Franasiak JM Juneau CR Morin SJ Neal SA Scott RT Goldberg JM
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
Efficacy of an intensive "surgical boot camp" on laparoscopic suturing performance among reproductive endocrinology and infertility (REI) fellows
Goodman L Yoo N Pfeifer S Scott RT Shah D
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation

Areas of Investigation

Investigators working in this area

Publications from this area

Presentations from this area

ESHRE 2020

SRI 2020

ASRM 2019

ASRM 2018

SRI 2018

ASRM 2017

Investigators
working in this area

Publications
from this area

Presentations
from this area