Endometrial receptivity
Interaction between the human embryo and the lining of the uterus (the endometrium) is critical when it comes to implantation, development of the placenta, and ultimately achieving a healthy pregnancy and live birth. This interaction between the embryo and endometrium is a complex and incompletely understood process.
The timing of this interaction during the window of implantation, leading to embryo and endometrial synchrony, has only recently been noted to be a critical factor. This is impacted by IVF laboratory conditions and embryonic growth as well as medical management of the ovarian stimulation and endometrial preparation. Work in this area seeks to better characterize the physiology and pathophysiology involved in this process in order to maximize the chance of a single, healthy live birth per embryo transfer.
Investigators working in this area
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Publications from this area
- Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure.
Sebastian-Leon P Garrido N Remohí J Pellicer A Diaz-Gimeno P
Hum Reprod. 2018 Feb 14. doi: 10.1093/humrep/dey023. [Epub ahead of print]
- Human Endometrial Reconstitution From Somatic Stem Cells: The Importance of Niche-Like Cells.
Lopez-Perez N Gil-Sanchis C Ferrero H Faus A Diaz A Pellicer A Cervelló I Simón C
Reprod Sci. 2018 Jan 1:1933719118766251. doi: 10.1177/1933719118766251. [Epub ahead of print]
- Proteomic pattern of implantative human endometrial fluid in in vitro fertilization cycles.
Matorras R Quevedo S Corral B Prieto B Exposito A Mendoza R Rabanal A Diaz-Nuñez M Ferrando M Elortza F Ametzazurra A Nagore D
Arch Gynecol Obstet. 2018 Apr 10. doi: 10.1007/s00404-018-4753-1. [Epub ahead of print]
- Why natural killer cells are not enough: a further understanding of killer immunoglobulin-like receptor and human leukocyte antigen.
Alecsandru D Garcia-Velasco J
Fertil Steril. 2017 Jun;107(6):1273-1278. doi: 10.1016/j.fertnstert.2017.04.018. Epub 2017 May 10. Review.
- Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers.
Altmae S Koel M Võsa U Adler P Suhorutšenko M Laisk-Podar T Kukushkina V Saare M Velthut-Meikas A Krjutškov K Aghajanova L Lalitkumar PG Gemzell-Danielsson K Giudice L Simón C Salumets A
Sci Rep. 2017 Aug 30;7(1):10077. doi: 10.1038/s41598-017-10098-3.
- De- and recellularization of the pig uterus: a bioengineering pilot study.
Campo H Baptista PM Lopez-Perez N Faus A Cervelló I Simón C
Biol Reprod. 2017 Jan 1;96(1):34-45. doi: 10.1095/biolreprod.116.143396.
- Impact of Endometrial Preparation Protocols for Frozen Embryo Transfer on Live Birth Rates.
Cerrillo M Herrero L Guillen A Mayoral M Garcia Velasco J
Rambam Maimonides Med J. 2017 Apr 28;8(2). doi: 10.5041/RMMJ.10297.
- Window of implantation transcriptomic stratification reveals different endometrial subsignatures associated with live birth and biochemical pregnancy.
Diaz-Gimeno P Ruiz-Alonso M Sebastian-Leon P Pellicer A Valbuena D Simón C
Fertil Steril. 2017 Aug 29. pii: S0015-0282(17)30502-2. doi: 10.1016/j.fertnstert.2017.07.007. [Epub ahead of print]
- Lipidomic profiling of endometrial fluid in women with ovarian endometriosis.
Dominguez F Ferrando M Diaz-Gimeno P Quintana F Fernandez G Castells I Simon C
Biol Reprod. 2017 Mar 18. doi: 10.1093/biolre/iox014. [Epub ahead of print]
- Contribution of immunology to implantation failure of euploid embryos.
Franasiak JM Scott RT
Fertil Steril. 2017 Jun;107(6):1279-1283. doi: 10.1016/j.fertnstert.2017.04.019. Epub 2017 May 10.
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Presentations from this area
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Alecsandru D Iglesias C Pacheco A Barrio A Garrido N Garcia Velasco J HLA-C haplotypes distribution among gametes donors in our population Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
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Devesa A Sebastian-Leon P Garcia-Garcia F Arnau V Pellicer A Diaz-Gimeno P
Functional genomic meta-analysis identifies similarities between endometrial-related subfertilities
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Salsano S Quiñonero A Pérez S González-Ravina C Simón C Dominguez F
Non-classical progesterone signaling may be sufficient to induce decidualization in Human Endometrial Stromal Cells (ESC)
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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Azkargorta M Escobes I Lloro I Osinalde N Corral B Exposito A Prieto B Elortza F Matorras R
Differential proteomic analysis of endometrial fluid suggets increased inflammation and extracellular matrix remodeling in non-implantative IVF cycles
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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López-Pérez N Santamaría X Díaz-Gimeno P Sebastian-Leon P Faus A Remohí J Pellicer A Simón C Cervelló I Stem Cell-Secreted Paracrine Factors in Human Endometrial Regeneration Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
SRI 2018
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Perez S Salsano S Quiñonero A Dominguez F
Phytoestrogens (Soy-Derived Metabolites) May Act Like Endometrial Disruptors Altering Decidualization of Human Endometrial Stromal Cells
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
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Colombo S Franasiak JM Kaser DJ Molinaro T Bergh PA Significance of endometrial lining decrease after progesterone start in synthetic frozen embryo transfer (FET) cycles Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2017
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Alecsandru D Pacheco A Garrido N Barrio A Aparicio P Pellicer A Garcia Velasco J Live birth rate after oocyte donation is influenced by donor HLA-C: one step beyond conventional markers of success Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017
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Diaz-Gimeno P Sebastian-Leon P Remohí J Garrido N Pellicer A
New transcriptomic insight improves endometrial Recurrent Implantation Failure (RIF) diagnosis and distinguishes clearly between a displaced and a disrupted Window Of Implantation (WOI)
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Grasso A Navarro R Moreno I Herrero M Alama A Vilella F Simon C
Differential microRNA profile in the endometrial fluid (EF)in natural cycles, HRT, and controlled ovarian stimulation (COS) triggered with hCG (COS+hCG) or GnRHa (COS+GnRHa)
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Laisk T Suhorutshenko M Kukushkina V Velthut-Meikas A Magi R Peters M Altmäe S Krjut?kov K Martinez-Blanch JF Codoñer FM Vilella F Simon C Salumets A
Novel endometrial receptivity markers detected in largescale RNA-sequencing study combining samples from different populations
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Santamaría Costa X Cabanillas S Arbona C Cervelló I Raga F Ferro J Palmero J Remohí J Pellicer A Simon C
Stem cell treatment for endometrial pathologies
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Santamaría X Cervelló I Cabanillas S Arbona C Raga F Ferro J Palmero J Remohí J Pellicer A Simon C
Human Reproduction keynote lecture - Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Balaguer N Moreno I Herrero M González-Montfort M Simón C Vilella F Maternal MiR-30d deficiency is associated with defects in endometrial receptivity, embryonic implantation and fetal development Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
SRI 2017
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Bolumart D Moreno I Herrero M Cabanillas S Vilella F Simón C
Extracellular vesicles secreted by the human endometrium contain specific DNA sequences that are uptaken by Murine Embryos
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Díaz-Gimeno P Ruiz-Alonso M Sebastián-León P Singh V Pellicer A Valbuena D Simón C
Improvement of the endometrial receptivity signature reveals a possible maternal origin of biochemical pregnancies
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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López-Pérez N Gil-Sanchis C Faus A Diaz A Campo H Pellicer A Cervelló I Carlos Simón
Human endometrial reconstitution using W5C5, ICAM1 cells and side population cell lines in a xenograft model
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Salsano S Quiñonero A Pérez S Simón C Domínguez F
Non Classical Progesterone Receptor and SERPINE1mRNA (PGRMC1) Binding Protein (SERBP1) Interaction Influences the Human Decidualization Process
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Sebastian-León P Conesa A Arnau V Remohí J Pellicer A Simón C Diaz-Gimeno P
Network biology of menstrual cycle to understand the key drivers of endometrial receptivity
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Vilella F Behr B Reddy V Wang W Navarro R Jiménez J Quake S C Simón
Maternal endometrial hsa-miR-30d is taken up by the human blastocyst and induces transcriptional modifications
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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