Endometrial receptivity
Interaction between the human embryo and the lining of the uterus (the endometrium) is critical when it comes to implantation, development of the placenta, and ultimately achieving a healthy pregnancy and live birth. This interaction between the embryo and endometrium is a complex and incompletely understood process.
The timing of this interaction during the window of implantation, leading to embryo and endometrial synchrony, has only recently been noted to be a critical factor. This is impacted by IVF laboratory conditions and embryonic growth as well as medical management of the ovarian stimulation and endometrial preparation. Work in this area seeks to better characterize the physiology and pathophysiology involved in this process in order to maximize the chance of a single, healthy live birth per embryo transfer.
Investigators working in this area
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Publications from this area
- Phytoestrogen exposure alters endometrial stromal cells and interferes with decidualization signaling.
Salsano S Pérez-Debén S Quiñonero A González-Martín R Domínguez F
Fertil Steril. 2019 Jul 29. pii: S0015-0282(19)30547-3. doi: 10.1016/j.fertnstert.2019.06.014. [Epub ahead of print]
- Inhibition of KIF20A by BKS0349 reduces endometriotic lesions in a xenograft mouse model.
Ferrero H Corachán A Quiñonero A Bougeret C Pouletty P Pellicer A Domínguez F
Mol Hum Reprod. 2019 Jul 31. pii: gaz044. doi: 10.1093/molehr/gaz044. [Epub ahead of print]
- Chronic endometritis is associated with an altered microbiome, but what about treatment and clinical outcomes?
Franasiak JM
Fertil Steril. 2019 Jul 29. pii: S0015-0282(19)30552-7. doi: 10.1016/j.fertnstert.2019.06.019. [Epub ahead of print] No abstract available.
- Tissue-specific decellularized endometrial substratum mimicking different physiological conditions influences in vitro embryo development in a rabbit model.
Campo H García-Domínguez X López-Martínez S Faus A Salvador Vicente Antón J Marco-Jiménez F Cervelló I
Acta Biomater. 2019 Mar 5. pii: S1742-7061(19)30170-9. doi: 10.1016/j.actbio.2019.03.004. [Epub ahead of print]
- Obstetrical complications of thin endometrium in assisted reproductive technologies: a systematic review.
Mouhayar Y Franasiak JM Sharara FI
J Assist Reprod Genet. 2019 Jan 25. doi: 10.1007/s10815-019-01407-y. [Epub ahead of print] Review
- Reply: Bone marrow-derived endometrial cells: what you see is what you get.
Santamaria X Mas A Cervelló I Taylor HS Simon C
Hum Reprod Update. 2018 Dec 21. doi: 10.1093/humupd/dmy042. [Epub ahead of print] No abstract available.
- Different Endometrial Receptivity in Each Hemiuterus of a Woman with Uterus Didelphys and Previous Failed Embryo Transfers.
Carranza F González-Ravina A Blasco V Fernández-Sánchez M
J Hum Reprod Sci, 11(3):297-299, 2018.
- Implantation failure of endometrial origin: what is new?
Bellver J Simón C
Curr Opin Obstet Gynecol, 30(4):229-236, 2018.
- Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure.
Sebastian-Leon P Garrido N Remohí J Pellicer A Díaz-Gimeno P
Hum Reprod, 33(4):626-635, 2018.
- Human Endometrial Reconstitution From Somatic Stem Cells: The Importance of Niche-Like Cells.
Lopez-Perez N Gil-Sanchis C Ferrero H Faus A Diaz A Pellicer A Cervelló I Simón C
Reprod Sci, NA:NA-NA, 2018.
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