Endometrial receptivity
Interaction between the human embryo and the lining of the uterus (the endometrium) is critical when it comes to implantation, development of the placenta, and ultimately achieving a healthy pregnancy and live birth. This interaction between the embryo and endometrium is a complex and incompletely understood process.
The timing of this interaction during the window of implantation, leading to embryo and endometrial synchrony, has only recently been noted to be a critical factor. This is impacted by IVF laboratory conditions and embryonic growth as well as medical management of the ovarian stimulation and endometrial preparation. Work in this area seeks to better characterize the physiology and pathophysiology involved in this process in order to maximize the chance of a single, healthy live birth per embryo transfer.
Investigators working in this area
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Publications from this area
- The lipidome of endometrial fluid differs between implantative and non-implantative IVF cycles.
Matorras R Martinez-Arranz I Arretxe E Iruarruzaga-Lejarreta M Corral B Ibañez-Perez J Exposito A Prieto B Elortza F Alonso C
J Assist Reprod Genet. 2019 Dec 21. doi: 10.1007/s10815-019-01670-z. [Epub ahead of print] - Endometrial receptivity and implantation in women with previous failed embryo transfers: to scratch or not to scratch?
Galliano D
Fertil Steril. 2019 Dec;112(6):1043. doi: 10.1016/j.fertnstert.2019.09.008. No abstract available. - Endometrial liquid biopsy provides a miRNA roadmap of the secretory phase of the human endometrium.
Grasso A Navarro R Balaguer N Moreno I Alama P Jimenez J Simon C Villela F
J Clin Endocrinol Metab. 2019 Oct 29. pii: dgz146. doi: 10.1210/clinem/dgz146. [Epub ahead of print] - The seminal microbiome in health and disease.
Altmae S Franasiak JM Mandar R
Nat Rev Urol. 2019 Nov 15. doi: 10.1038/s41585-019-0250-y. [Epub ahead of print] Review. - The endometrial immune environment of women with endometriosis.
Vallvé-Juanico J Houshdaran S Giudice LC
Hum Reprod Update. 2019 Sep 11;25(5):564-591. doi: 10.1093/humupd/dmz018. - Phytoestrogen exposure alters endometrial stromal cells and interferes with decidualization signaling.
Salsano S Pérez-Debén S Quiñonero A González-Martín R Domínguez F
Fertil Steril. 2019 Jul 29. pii: S0015-0282(19)30547-3. doi: 10.1016/j.fertnstert.2019.06.014. [Epub ahead of print] - Inhibition of KIF20A by BKS0349 reduces endometriotic lesions in a xenograft mouse model.
Ferrero H Corachán A Quiñonero A Bougeret C Pouletty P Pellicer A Domínguez F
Mol Hum Reprod. 2019 Jul 31. pii: gaz044. doi: 10.1093/molehr/gaz044. [Epub ahead of print] - Chronic endometritis is associated with an altered microbiome, but what about treatment and clinical outcomes?
Franasiak JM
Fertil Steril. 2019 Jul 29. pii: S0015-0282(19)30552-7. doi: 10.1016/j.fertnstert.2019.06.019. [Epub ahead of print] No abstract available. - Tissue-specific decellularized endometrial substratum mimicking different physiological conditions influences in vitro embryo development in a rabbit model.
Campo H García-Domínguez X López-Martínez S Faus A Salvador Vicente Antón J Marco-Jiménez F Cervelló I
Acta Biomater. 2019 Mar 5. pii: S1742-7061(19)30170-9. doi: 10.1016/j.actbio.2019.03.004. [Epub ahead of print] - Obstetrical complications of thin endometrium in assisted reproductive technologies: a systematic review.
Mouhayar Y Franasiak JM Sharara FI
J Assist Reprod Genet. 2019 Jan 25. doi: 10.1007/s10815-019-01407-y. [Epub ahead of print] Review
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Presentations from this area
- Gonzalez-Martin R Palomar A Pérez-Debén S Quiñonero A Dominguez F Presented at the 67th Annual Meeting of the Society for Reproductive Investigation Vancouver ,Canada Endometrial receptivity Female fertility F-209 Mercury Disturbs Reproductive Functions of Primary Endometrial Stromal Cells (ESC). Presented at 75th American Society of Reproductive Medicine Scientific Congress
SRI 2020
- Calonge M Machuca D Morales B Troncoso C Meseguer M Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology Copenhagen,Denmark IVF laboratory A PROSPECTIVE RANDOMIZED SIBLING-OOCYTE STUDY OF TWO UNINTERRUPTED MEDIA SYSTEMS FOR CULTURING BLASTOCYSTS. Presented at 75th American Society of Reproductive Medicine Scientific Congress
ESHRE 2020
- Santolaria Baig A Quintana Berto Garcia Camuñas N Subirá Nadal J Polo Sánchez P Rubio Rubio JM Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology Copenhagen,Denmark IVF clinical Cryobiology Fertility preservation in adolescent women: should we expect the same response? Presented at 75th American Society of Reproductive Medicine Scientific Congress
- Neal SA Tao X Sun L Hanson BM Kim G Osman EK Tiegs AW Scott RT Franasiak JM P-219 HIGH CONCORDANCE BETWEEN VAGINAL AND CERVICAL MICROBIOME ASSESSMENTS WITH INCREASING MICROBIAL DIVERSITY NEGATIVELY IMPACTS PREGNANCY OUTCOMES FOLLOWING TRANSFER OF A SINGLE EUPLOID BLASTOCYST Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology
ASRM 2019
- Nohales Corcoles M Del Gallego R Bori L Alegre L S. Shnizer Meseguer M P-246: High culture media oxidative profile as a biomarker of good quality embryos: a non-invasive tool to select the embryo to transfer. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ESHRE 2019
- Garrido N O-223: Finding the best sperm Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
- Ferrero H Corachán A Quiñonero A Carbajo-García C Alamá P Tejera A Taboas E Muñoz E Pellicer A Domínguez F NGS of Oocytes from Endometriosis Patients Reveals a Differential Transcriptomic Pattern Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2019
- Pellegrini L Buigues A Sebastián-León P Diaz-Gimeno P Pellicer A Herraiz S Transcriptomic Changes and Paracrine Factors Involved in Ovarian Rejuvenation Induced by Stem Cell_ Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
- Salsano S Quiñonero A Yañez-Mo Gómez A Pérez S Dominguez F Novel Non-Classic Progesterone P4 Receptor PGRMC1 Interactions and Functionality Reveal a Key Role Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
- Pirtea P Marin D Sun L Hong K Zhan Y Tao X Scott RT Gonadotrophin receptor polymorphisms (fshr n680s and lhcgr n312s) are not of clinical outcome and live birth in ivf cycles Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
ASRM 2018
- Bellver J Lathi RB Labarta E Vidal C Giles J Cabanillas S Marzal A Galliano D Marin C Ruiz-Alonso M Simón C Valbuena D Obesity affects endometrial receptivity by inducing a displacement of the personalized woi that after correction by personalized embryo transfer normalize clinical results Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
- Insua M Escriba M Vendrell X Peinado V Viloria T Segmental aneuploidy in blastocysts: when the chromosomes break Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Sakkas D Atkinson L Borini A Bosch E Bryce C Cattoli M Finet de Bantel A French B Gaitonde S Gerris J Granger S Grzegorczk-Martin V Howles C Somers S Alper M Can "patient-friendly" salivary hormone measurements replace serum monitoring of IVF Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
- Fatemi H Griesinger G Teal V Polyzos N Bosch E Johnson B Dos Santos S Garcia Velasco J Stoop D FSH exposure between day 8 and day of Hcg administration is an independent predictor of serum progesterone rise Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
- Buigues A Herraiz S Marchante M Hsueh A J Pellicer A Fertility Rescue by Bone Marrow Derived Stem Cell Infusion Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2018
- Perez S Salsano S Quiñonero A Dominguez F Phytoestrogens (Soy-Derived Metabolites) May Act Like Endometrial Disruptors Altering Decidualization of Human Endometrial Stromal Cells Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
- Cobo A Meseguer M Coello A Sanchez E Garcia Velasco J Remohí J Pellicer A Estimation of reproductive success according to age, number of oocytes and etiology in elective or oncological fertility preservation (FP) patients Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2017
- Coello A Sanchez E Campos P Vallejo B Meseguer M Cobo A Oocyte dysmorphisms are not associated with post warming survival, fertilization and embryo development in own oocytes vitrification cycles Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
- Esbert M Marconetto A Reis Soares S Quera M Molina J Florensa M Ballesteros A Meseguer M Does the blastocyst collapse respond to a biological need? The analysis of 1,952 embryos by time-lapse can give an answer Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
- Franasiak JM Hong KH Werner MD Juneau CR Morin SJ Neal SA Molinaro T Scott RT Preimplantation genetic screening (PGS) in low responders shortens time to pregnancy: a randomized controlled trial Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
- Franasiak JM Scott RT Molina L Pellicer A Serum vitamin D (OHD) levels are correlated with embryonic aneuploidy Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
- Goodman L Yoo N Pfeifer S Scott RT Shah D Efficacy of an intensive "surgical boot camp" on laparoscopic suturing performance among reproductive endocrinology and infertility (REI) fellows Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
- Juneau CR Franasiak JM Morin SJ Werner MD Upham K Scott RT Enmotion (embryo's natural motion): a paired randomized controlled trial demonstrating pregnancy rates are equivalent between static and dynamic culture systems Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
- Juneau CR Marin D Scott K Morin SJ Neal SA Juneau J Scott RT Cares trial (celiac disease and reproductive effects): a gluten-free diet does not impact IVF outcomes Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
- Juneau CR Marin D Scott K Morin SJ Neal SA Juneau J Scott RT Cares trial (celiac disease and reproductive effects): celiac disease is not more common in patients undergoing IVF and outcomes are not compromised in affected patients Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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