Endometrial receptivity
Interaction between the human embryo and the lining of the uterus (the endometrium) is critical when it comes to implantation, development of the placenta, and ultimately achieving a healthy pregnancy and live birth. This interaction between the embryo and endometrium is a complex and incompletely understood process.
The timing of this interaction during the window of implantation, leading to embryo and endometrial synchrony, has only recently been noted to be a critical factor. This is impacted by IVF laboratory conditions and embryonic growth as well as medical management of the ovarian stimulation and endometrial preparation. Work in this area seeks to better characterize the physiology and pathophysiology involved in this process in order to maximize the chance of a single, healthy live birth per embryo transfer.
Investigators working in this area
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Publications from this area
- Different Endometrial Receptivity in Each Hemiuterus of a Woman with Uterus Didelphys and Previous Failed Embryo Transfers.
Carranza F González-Ravina A Blasco V Fernández-Sánchez M
J Hum Reprod Sci, 11(3):297-299, 2018.
- Implantation failure of endometrial origin: what is new?
Bellver J Simón C
Curr Opin Obstet Gynecol, 30(4):229-236, 2018.
- Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure.
Sebastian-Leon P Garrido N Remohí J Pellicer A Díaz-Gimeno P
Hum Reprod, 33(4):626-635, 2018.
- Human Endometrial Reconstitution From Somatic Stem Cells: The Importance of Niche-Like Cells.
Lopez-Perez N Gil-Sanchis C Ferrero H Faus A Diaz A Pellicer A Cervelló I Simón C
Reprod Sci, NA:NA-NA, 2018.
- Proteomic pattern of implantative human endometrial fluid in in vitro fertilization cycles.
Matorras R Quevedo S Corral B Prieto B Exposito A Mendoza R Rabanal A Diaz-Nuñez M Ferrando M Elortza F Ametzazurra A Nagore D
Arch Gynecol Obstet, 297(6):1577-1586, 2018.
- Natural killer cells in reproduction: helpful, harmful, or misunderstood?
Morin SJ Franasiak JM
Consider This: Fertility and Sterility Dialog. May 2017.
- Mu opioid receptor in the human endometrium: dynamics of its expression and localization during the menstrual cycle.
Totorikaguena L Olabarrieta E Matorras R Alonso E Agirregoitia E Agirregoitia N
Fertil Steril, 107:1070-1077, 2017.
- Role of Stro1+/CD44+ stem cells in myometrial physiology and uterine remodeling during pregnancy.
Mas A Prusinski L Yang Q Díaz-Gimeno P Stone L Diamond MP Simón C Al-Hendy A
Biol Reprod. 2017 Jan 1;96(1):70-80. doi: 10.1095/biolreprod.116.14346
- Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology.
Garrido-Gomez T Domínguez F Quiñonero A Díaz-Gimeno P Kapidzic M Gormley M Ona K Padilla-Iserte P McMaster M Genbacev O Perales A Fisher SJ Simón C
Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8468-E8477. doi: 10.1073/pnas.1706546114. Epub 2017 Sep 18
- Impact of Endometrial Preparation Protocols for Frozen Embryo Transfer on Live Birth Rates.
Cerrillo M Herrero L Guillen A Mayoral M García-Velasco JA
Rambam Maimonides Med J. 2017 Apr 28;8(2). doi: 10.5041/RMMJ.10297.
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Presentations from this area
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