The genomics revolution has fundamentally reshaped our understanding of multiple facets of reproductive medicine. Indeed errors in the DNA blueprint or chromosome copy number can now be easily identified and associated pathology can be avoided. However, a greater appreciation for the impact that epigenetic marks (such as DNA methylation, histone modification, or microRNA post-transcriptional processing) have on the success of gene expression has recently emerged.
Researchers at IVIRMA Global are devising strategies to characterize the methylation profiles of gametes and preimplantation embryos with an eye towards identifying abnormalities that are associated with failed embryogenesis and implantation. In addition, ongoing projects are examining the predictive power of methylation levels in somatic cells in identifying early, subtle signs of reproductive aging.
Investigators working in this area
Publications from this area
- What the human sperm methylome tells us.
Camprubí C Cigliano RA Salas-Huetos A Garrido N Blanco J.
Epigenomics. 2017 Sep 7. doi: 10.2217/epi-2017-0049. [Epub ahead of print]
Presentations from this area
Morin SJ Tao X Bedard J Landis J Zhan Y Scott RT Seli E Epigenetic Clock Model of Somatic Aging Accurately Predicts Chronologic Age When Applied to White Blood Cells But Not Cumulus Cells in Reproductive Age Women Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
Tao X Zhan Y Scott K Scott RT Seli E
DNA methylation is associated with ploidy status, delayed blastulation, and patient age in human embryos
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
Tao X Zhan Y Scott K Scott RT Seli E Assessment of DNA methylation in human embryos Presented at the 73rd annual meeting of the American Society of Reproductive Medicine