Epigenetics
The genomics revolution has fundamentally reshaped our understanding of multiple facets of reproductive medicine. Indeed errors in the DNA blueprint or chromosome copy number can now be easily identified and associated pathology can be avoided. However, a greater appreciation for the impact that epigenetic marks (such as DNA methylation, histone modification, or microRNA post-transcriptional processing) have on the success of gene expression has recently emerged.
Researchers at IVIRMA Global are devising strategies to characterize the methylation profiles of gametes and preimplantation embryos with an eye towards identifying abnormalities that are associated with failed embryogenesis and implantation. In addition, ongoing projects are examining the predictive power of methylation levels in somatic cells in identifying early, subtle signs of reproductive aging.
Investigators working in this area
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Publications from this area
- Long-term vitamin D treatment decreases human uterine leiomyoma size in a xenograft animal model.
Corachán A Ferrero H Escrig J Monleon J Faus A Cervelló I Pellicer A
Fertil Steril. 2019 Nov 15. pii: S0015-0282(19)32372-6. doi: 10.1016/j.fertnstert.2019.09.018. [Epub ahead of print]
- Oocyte and Embryo Manipulation and Epigenetics.
Osman E Franasiak J Scott RT
Semin Reprod Med. 2018 May;36(3-04):e1-e9. doi: 10.1055/s-0039-1688801. Epub 2019 May 14.
- Obesity, male infertility, and the sperm epigenome. [Review].
Craig JR Jenkins TG Carrell DT Hotaling J
Fertil Steril, 107(4), 848-859, 2017.
- Cigarette smoking significantly alters sperm DNA methylation patterns.
Jenkins TG James ER Alonso DF Hoidal JR Murphy PJ Hotaling J Cairns BR Carrell DT Aston KI
Andrology, 5(6), 1089 1099,2017.
- Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development.
Guo J Grow EJ Yi C Mlcochova H Maher GJ Lindskog C Murphy PJ Wike CL Carrell DT Goriely A Hotaling J Cairns BR
Cell Stem Cell, 21(4), 533-546.e6, 2017.
- What the human sperm methylome tells us.
Camprubí C Cigliano RA Salas-Huetos A Garrido N Blanco J.
Epigenomics. 2017 Sep 7. doi: 10.2217/epi-2017-0049. [Epub ahead of print]
- Intra-sample heterogeneity of sperm DNA methylation.
Jenkins TG Aston K Trost C Farley J Hotaling J Carrell D
Mol Hum Reprod, 21(4), 313-9, 2015.
- Global deoxyribonucleic acid methylation: a window into the spermatogonial stem cell's reproductive potential.
Hotaling J
Fertil Steril, 104(6), 1374-5, 2015.
- Lack of association of MTHFR rs1801133 polymorphism and CTCFL mutations with sperm methylation errors in infertile patients
Camprubí C Pladevall M Grossmann M Garrido N Pons MC Blanco J
J Assist Reprod Genet, 30:1125-1131, 2013.
Presentations from this area
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Giles J Mercader A Rubio C Vidal C Alegre L Trabalon M Meseguer M P-332 PGT-A (preimplantational genetic screening) in patients with partial X monosomy using own oocytes: is a suitable indication? Presented at 75th American Society of Reproductive Medicine Scientific Congress
ASRM 2019
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Meseguer M
O-9 Would an automated system detecting embryo developmental events select the same embryo as an embryologist using a morphokinetic algorithm?
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Hanson BM Tao X Zhan Y Jenkins TG Scott RT Seli E
O-79 THE RELATIONSHIP BETWEEN CHRONOLOGIC AGE, OVARIAN RESPONSE, AND DNA METHYLATION OF WHITE BLOOD CELLS AND CUMULUS CELLS AMONG INFERTILE WOMEN UNDERGOING IVF
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Tao X Zhan Y Scott KL Scott RT Seli E
P-55 COMPARATIVE ANALYSIS OF DNA METHYLATION IN EUPLOID AND ANEUPLOID HUMAN EMBRYOS USING REDUCED REPRESENTATION BISULFITE SEQUENCING
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Tiegs AW Tao X Whitehead CR Neal SA Osman EK Kim G Hanson BM Seli E Patounakis G Gutmann J Castlebaum A
O-74 DOES PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A) HARM EMBRYOS? NO—A MULTI-CENTER, PROSPECTIVE, BLINDED, NON-SELECTION STUDY EVALUATING THE PREDICTIVE VALUE OF AN ANEUPLOID DIAGNOSIS AND IMPACT OF BIOPSY
Presented at 75th American Society of Reproductive Medicine Scientific Congress
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Tao X Zhan Y Scott KL Scott RT Seli E Dna methylation is associated with ploidy status and patient age in human embryos Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ASRM 2018
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Morin SJ Tao X Bedard J Landis J Zhan Y Scott RT Seli E Epigenetic Clock Model of Somatic Aging Accurately Predicts Chronologic Age When Applied to White Blood Cells But Not Cumulus Cells in Reproductive Age Women Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
SRI 2018
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Tao X Zhan Y Scott K Scott RT Seli E
DNA methylation is associated with ploidy status, delayed blastulation, and patient age in human embryos
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
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Tao X Zhan Y Scott K Scott RT Seli E Assessment of DNA methylation in human embryos Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2017