Aging and Rejuvenation
The consequences of reproductive aging are encountered on a daily basis in the infertility clinic. With this in mind, researchers at IVI RMA Global are working to identify the mechanisms responsible for reproductive aging.
These projects include studies on:
- changes in the epigenome associated with aging,
- telomere dynamics in gametes and peripheral blood
- mitochondrial function in preimplantation embryos.
The scientific team is also focused on devising treatment strategies to activate dormant follicles in patients at advanced stages of reproductive aging. These techniques have produced pregnancies in multiple patients with a diagnosis of primary ovarian insufficiency (also termed premature ovarian failure).
Investigators working in this area
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Publications from this area
- Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency.
Cakiroglu Y Saltik A Yuceturk A Karaosmanoglu O Kopuk SY Scott RT Tiras B Seli E
Aging (Albany NY). 2020 Jun 5;12(11):10211-10222. doi: 10.18632/aging.103403. Epub 2020 Jun 5.
- The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes.
ElInati E Zielinska AP McCarthy A Kubikova N Maciulyte V Mahadevaiah S Sangrithi MN Ojarikre O Wells D Niakan KK Schuh M Turner JMA
Nat Commun. 2020 May 25;11(1):2598. doi: 10.1038/s41467-020-16441-z.
- Comparison of pregnancy outcomes following intrauterine insemination in young women with decreased versus normal ovarian reserve.
Ashley W. Tiegs Sun L Scott RT R. Goodman L
Fertility and SterilityIn press, corrected proofAvailable online 6 March 2020
- Estrategias de mejora de la fertilidad: preservación rejuvenecimiento y células madre.
Acosta-Bueno C Antonio Cejudo-Román Salazar-Vera A Quiroga-Gil R
Medicina Reproductiva y Embriología Clínica, Volume 7, Issue 1, January–April 2020, Pages 33-49
- Cumulus cells have longer telomeres than leukocytes in reproductive-age women.
Lara EE Franasiak JM Marin D Tao X Diaz-Gimeno P Florensa M Martin M Seli E Pellicer A
Fertil Steril. 2019 Oct 6. pii: S0015-0282(19)32299-X. doi: 10.1016/j.fertnstert.2019.08.089. [Epub ahead of print]
- Impact of Ovarian Aging in Reproduction: From Telomeres and Mice Models to Ovarian Rejuvenation.
Polonio AM Chico-Sordo L Córdova-Oriz I Medrano M García-Velasco JA Varela E
Yale J Biol Med. 2020 Sep 30;93(4):561-569. eCollection 2020 Sep.
- Young women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model.
Hanson BM Tao X Zhan Y Jenkins TG Morin SJ Scott RT Seli EU
Hum Reprod. 2020 Nov 1;35(11):2579-2588. doi: 10.1093/humrep/deaa206.
- Correction to: Diminished Ovarian Reserve Chemotherapy-Induced Mouse Model: A Tool for the Preclinical Assessment of New Therapies for Ovarian Damage.
Buigues A Marchante M Herraiz S Pellicer A
Reprod Sci. 2020 Nov 10. doi: 10.1007/s43032-020-00379-0. Online ahead of print.
- Diminished Ovarian Reserve Chemotherapy-Induced Mouse Model: A Tool for the Preclinical Assessment of New Therapies for Ovarian Damage.
Buigues A Marchante M Herraiz S Pellicer A
Reprod Sci. 2019 Feb 21:1933719119831784. doi: 10.1177/1933719119831784. [Epub ahead of print]
- Diminished ovarian reserve versus ovarian aging: overlaps and differences.
Ata B Seyhan A Seli E
Curr Opin Obstet Gynecol. 2019 Feb 18. doi: 10.1097/GCO.0000000000000536. [Epub ahead of print]
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Presentations from this area
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Polonio AM González-García MT Córdova-Oriz I Marta Medrano Chico-Sordo L Garcia-Velasco JA Elisa Varela P-280 CHARACTERIZATION OF TELOMERE STATUS DURING OVARIAN AGING IN THE SAMP8 (SENESCENCE ACCELERATED MOUSE PRONE 8) MODEL. Presented at 76th American Society of Reproductive Medicine Scientific Congress
ASRM2020
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Cakiroglu Y Saltik A Yuceturk A Karaosmanoglu O Yildirim Kopuk S Scott RT Seli E
P-123 FOLLICULAR ACTIVATION BY INTRAOVARIAN INJECTION OF AUTOLOGOUS PLATELET RICH PLASMA (PRP) IN WOMEN WITH PRIMARY OVARIAN INSUFFICIENCY (POI): IMPACT ON OVARIAN RESERVE AND IVF OUTCOME.
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Cakiroglu Y Saltik A Yuceturk A Karaosmanoglu O Yildirim Kopuk S Scott RT Seli E
P-864 OVARIAN RESERVE PARAMETERS AND IVF OUTCOMES IN 510 WOMEN WITH POOR OVARIAN RESPONSE (POR) TREATED WITH INTRAOVARIAN INJECTION OF AUTOLOGOUS PLATELET RICH PLASMA (PRP)
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Cozzolino M Titus S Herraiz S Pellicer A Scott RT Seli E
P-608 IN YOUNG WOMEN WITH POOR OVARIAN RESPONSE (POR), MICRORNA EXPRESSION IN PERIPHERAL BLOOD MONONUCLEAR (PBMN) CELLS IS ALTERED COMPARED TO NORMO-RESPONDER CONTROLS
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Exacoustos C Cosentino M Loiudice L Martire FG Galliano D Pellicer A
P-355 IMPACT OF ULTRASOUND DIAGNOSIS OF ADENOMYOSIS ON PREGNANCY RATE AND OUTCOME IN IVF CYCLES WITH DONATED OOCYTES: A PROSPECTIVE STUDY
Presented at 76th American Society of Reproductive Medicine Scientific Congress
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Pellicer N Herraiz S Martínez RM Buigues A Gómez-Seguí I Martínez J Pellicer A O-088 Bone marrow derived stem cells restore ovarian function and fertility in premature ovarian insufficiency women. Interim report of a randomized trial: mobilization versus ovarian injection. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2020
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Buigues A Marchante M Martínez J Pellicer A Herraiz S 0-143 G-CSF Mobilized Plasma Regenerate Ovarian Stroma and Restore Ovarian Function. Presented at the 67th Annual Meeting of the Society for Reproductive Investigation
SRI 2020
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Devesa-Peiro A Sebastian-Leon P Pellicer A Diaz-Gimeno P
T-206 Endometrial Aging Evidence at Transcriptomic Level
Presented at the 67th Annual Meeting of the Society for Reproductive Investigation
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Grau Gonzalez-Picazo A Soler N Escribá MJ Vendrell X Viloria T P-417 Effect of different 6-dimethylaminopurine (6-DMAP) treatments on reversible arresting of mono and tripronuclear embryos at the pronuclear stage Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2019
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Marugappan G Kim G Kort JD Hanson BM Neal SA Tiegs AW Osman EK Scott RT Lathi RB
P-110 Blastocyst grade predicts outcome after frozen euploid transfer in patients with recurrent pregnancy loss
Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
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Pool G Rogers S Mania A Everett G Doshi AM Srikantharajah S Joshi HN Wilding M Bishop S Muriel L Maalouf W Hickman C
P-455 Multi-site, blind prospective trial assessing whether semen oxidation reduction potential (SORP) assessment can be used to predict low fertilisation with conventional IVF: interim analysis
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Meseguer M Bori L Del Gallego R Remohí J Quinonero A Dominguez F P-134: Protein profile of euploid single embryo transfer reveals differential patterns among them. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ESHRE 2019
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Gonzalez-Martin R Telez-Plaza M Domínguez F Association of Blood Cadmium and Lead Levels with Reproductive Lifespan Among Postmenopausal Women: NHANES 2005-2014. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2019
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Morin SJ Wang T Tao X Earnhardt M Seli E Scott RT Ultra-low oxygen (o2) tension after day 3 of in vitro development does not alter blastocyst transcriptome: a comparison of 2% versus 5% o2 tension in extended culture Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2018
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Pirtea P Marin D Sun L Hong K Zhan Y Tao X Scott RT
Gonadotrophin receptor polymorphisms (fshr n680s and lhcgr n312s) are not of clinical outcome and live birth in ivf cycles
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
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Kim G Morin SJ Patounakis G Juneau C Neal SA
Abc trial: appraisal of body content. Frozen embryo cycles are not impacted by the negative effects of obesity seen in fresh cycles
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
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Tiegs W Tao X Landis J Rajchel J Bedard JL Seli E Wells D Fragouli E Scott RT
Evaluation of sperm mitochondrial dna copy number as a predictor of in vitro fertilization/intracytoplasmic sperm injection (ivf/icsi) cycle outcomes in a large infertile population
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
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Devesa A Sebastian-Leon P Garcia-Garcia F Arnau V Pellicer A Diaz-Gimeno P Functional genomic meta-analysis identifies similarities between endometrial-related subfertilities Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ESHRE 2018
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López-Pérez N Santamaría X Díaz-Gimeno P Sebastian-Leon P Faus A Remohí J Pellicer A Simón C Cervelló I Stem Cell-Secreted Paracrine Factors in Human Endometrial Regeneration Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2018
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Cobo A Meseguer M Coello A Sanchez E Garcia Velasco J Remohí J Pellicer A Estimation of reproductive success according to age, number of oocytes and etiology in elective or oncological fertility preservation (FP) patients Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2017
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Coello A Sanchez E Campos P Vallejo B Meseguer M Cobo A
Oocyte dysmorphisms are not associated with post warming survival, fertilization and embryo development in own oocytes vitrification cycles
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Garnsey HM Eccles JM Iturriaga A Scott RT Zimmerman RS
Incidental diagnosis of a parental balanced reciprocal rearrangement in couples undergoing routine aneuploidy screening by targeted next generation sequencing (TNGS)
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
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Goodman L Khan Z Franasiak JM Juneau CR Morin SJ Neal SA Scott RT Goldberg JM
Current surgical experience and deficits in reproductive endocrinology and infertility training across fellowships in the United States
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation