Aging and Rejuvenation
The consequences of reproductive aging are encountered on a daily basis in the infertility clinic. With this in mind, researchers at IVI RMA Global are working to identify the mechanisms responsible for reproductive aging.
These projects include studies on:
- changes in the epigenome associated with aging,
- telomere dynamics in gametes and peripheral blood
- mitochondrial function in preimplantation embryos.
The scientific team is also focused on devising treatment strategies to activate dormant follicles in patients at advanced stages of reproductive aging. These techniques have produced pregnancies in multiple patients with a diagnosis of primary ovarian insufficiency (also termed premature ovarian failure).
Investigators working in this area
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Publications from this area
- Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance.
Morin SJ Patounakis G Juneau CR Neal SA Scott RT Seli E
Hum Reprod, 33(8):1489-1498, 2018.
- Mathematical model to study the aging of the human follicle according to the telomerase activity.
Portillo AM Varela E García-Velasco JA
J Theor Biol, 462:446-454, 2018.
- DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation.
Morin SJ Tao X Marin D Zhan Y Landis J Bedard J Scott RT Seli E
Aging (Albany NY), 10(12):3761-3773, 2018.
- Autologous stem cell ovarian transplantation to increase reproductive potential in patients who are poor responders.
Herraiz S Romeu M Buigues A Martínez J Díaz-García C Gómez-Seguí I Pellicer N Pellicer A
Fertil Steril, 110(3):496-505, 2018.
- Fertility, IVF and reproductive genetics.
Varela E Sánchez-de-Puerta I García-Velasco JA
Curr Opin Obstet Gynecol, 30(3):203-208, 2018.
- Should we consider telomere length and telomerase activity in male factor infertility?
Balmori C Varela E
Curr Opin Obstet Gynecol, 30(3):197-202, 2018.
- The dilemma of aneuploidy screening on low responders.
Morin SJ Kaser DJ Franasiak JM
Curr Opin Obstet Gynecol, 30(3):179-184, 2018.
- Selection of preimplantation embryos using time-lapse microscopy in in vitro fertilization: State of the technology and future directions.
Aparicio-Ruiz B Romany L Meseguer M
Birth Defects Res, 110(8):648-653, 2018.
- Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos.
Wang T Babayev E, Jiang Z Li G Zhang M Esencan E Horvath T Seli E
Aging Cell, 30:e12784. doi: 10.1111/acel.12784, 2018.
- Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion.
Herraiz S Buigues A Díaz-García C Romeu M Martínez S Gómez-Seguí I Simón C Hsueh AJ Pellicer A
Fertil Steril, 109(5):908-918, 2018.
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