Aging and Rejuvenation
The consequences of reproductive aging are encountered on a daily basis in the infertility clinic. With this in mind, researchers at IVI RMA Global are working to identify the mechanisms responsible for reproductive aging.
These projects include studies on:
- changes in the epigenome associated with aging,
- telomere dynamics in gametes and peripheral blood
- mitochondrial function in preimplantation embryos.
The scientific team is also focused on devising treatment strategies to activate dormant follicles in patients at advanced stages of reproductive aging. These techniques have produced pregnancies in multiple patients with a diagnosis of primary ovarian insufficiency (also termed premature ovarian failure).
Investigators working in this area
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Publications from this area
- Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance.
Morin SJ Patounakis G Juneau CR Neal SA Scott RT Seli E
Hum Reprod, 33(8):1489-1498, 2018.
- Mathematical model to study the aging of the human follicle according to the telomerase activity.
Portillo AM Varela E García-Velasco JA
J Theor Biol, 462:446-454, 2018.
- DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation.
Morin SJ Tao X Marin D Zhan Y Landis J Bedard J Scott RT Seli E
Aging (Albany NY), 10(12):3761-3773, 2018.
- Autologous stem cell ovarian transplantation to increase reproductive potential in patients who are poor responders.
Herraiz S Romeu M Buigues A Martínez J Díaz-García C Gómez-Seguí I Pellicer N Pellicer A
Fertil Steril, 110(3):496-505, 2018.
- Fertility, IVF and reproductive genetics.
Varela E Sánchez-de-Puerta I García-Velasco JA
Curr Opin Obstet Gynecol, 30(3):203-208, 2018.
- Should we consider telomere length and telomerase activity in male factor infertility?
Balmori C Varela E
Curr Opin Obstet Gynecol, 30(3):197-202, 2018.
- The dilemma of aneuploidy screening on low responders.
Morin SJ Kaser DJ Franasiak JM
Curr Opin Obstet Gynecol, 30(3):179-184, 2018.
- Selection of preimplantation embryos using time-lapse microscopy in in vitro fertilization: State of the technology and future directions.
Aparicio-Ruiz B Romany L Meseguer M
Birth Defects Res, 110(8):648-653, 2018.
- Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos.
Wang T Babayev E, Jiang Z Li G Zhang M Esencan E Horvath T Seli E
Aging Cell, 30:e12784. doi: 10.1111/acel.12784, 2018.
- Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion.
Herraiz S Buigues A Díaz-García C Romeu M Martínez S Gómez-Seguí I Simón C Hsueh AJ Pellicer A
Fertil Steril, 109(5):908-918, 2018.
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Presentations from this area
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Jiang Z Duan J Wang T Zhang M Tian X Seli E Evaluating mitochondrial stress response gene clpp-regulated dna methylome dynamics in female reproductive aging Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
ASRM 2018
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Lara EE Franasiak JM Marin D Tao X Díaz-Gimeno P Florensa M Martin M Seli E Pellicer A
Cumulus cells have longer telomeres than leukocytes in reproductive age women
Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine
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Labarta E Herraiz S De Los Santos MJ Marzal A Jose Escribá M Buigues A Pellicer A Autologous mitochondrial transfer (AugmentSM) as a complementary technique to ICSI to improve oocyte and embryo quality in IVF patients. A Randomized Pilot Study. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2018
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Labarta E Herraiz S De Los Santos MJ Marzal A Jose Escribá M Buigues A Pellicer A
Autologous stem cell ovarian transplant to improve ovarian response and reproductive outcomes in poor responder patients
Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
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López-Pérez N Santamaría X Díaz-Gimeno P Sebastian-Leon P Faus A Remohí J Pellicer A Simón C Cervelló I Stem Cell-Secreted Paracrine Factors in Human Endometrial Regeneration Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
SRI 2018
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Morin SJ Tao X Bedard J Landis J Zhan Y Scott RT Seli E
Epigenetic Clock Model of Somatic Aging Accurately Predicts Chronologic Age When Applied to White Blood Cells But Not Cumulus Cells in Reproductive Age Women
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
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Tao X Zhan Y Scott K Scott RT Seli E
DNA methylation is associated with ploidy status, delayed blastulation, and patient age in human embryos
Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
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Tao X Zhan Y Scott K Scott RT Seli E Assessment of DNA methylation in human embryos Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ASRM 2017
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Herraiz S Romeu M Martínez S Solves P Gómez I Martínez J Buigues A Galliano D Simón C Díaz-García C Pellicer A Two live birth after Stem cell ovarian auto-transplantation in Poor Responder women Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2017
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Santamaría Costa X Cabanillas S Arbona C Cervelló I Raga F Ferro J Palmero J Remohí J Pellicer A Simon C
Stem cell treatment for endometrial pathologies
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Santamaría X Cervelló I Cabanillas S Arbona C Raga F Ferro J Palmero J Remohí J Pellicer A Simon C
Human Reproduction keynote lecture - Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study
Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
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Herraiz S Buigues A Romeu M Díaz-García C Hsueh A Pellicer A Infusion Of Human Bone Marrow-Derived Stem Cells Improved Ovarian Function In Chemotherapy-Damaged Ovaries In Mice Presented at the 64th Annual Meeting of the Society for Reproductive Investigation
SRI 2017
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Herraiz S Romeu M Martínez S Díaz-García C Solves P Gómez I Martínez J Anna Buigues Simón C Galliano D Pellicer A
Two Live Birth After Stem Cell Ovarian Auto-Transplantation In PR Women
Presented at the 64th Annual Meeting of the Society for Reproductive Investigation