Pre-implantation Genetics
The “holy grail” of reproductive medicine is to discover a technology allowing identification of those embryos that have true reproductive potential as evidenced by implantation, normal obstetrical course, and delivery of a healthy infant. While it may seem counter-intuitive that a normally developing embryo cannot implant, the reality is that many factors limit reproductive competence of the embryo that do not impact these early morphologic markers. Chief amongst these are the meiotic and mitotic errors that lead to an imbalance in the number of chromosomes present in the embryo, termed embryonic aneuploidy.
Embryonic aneuploidy is a significant factor in limiting the efficiency of reproduction, even amongst young women. We have extensively studied and validated aneuploidy testing and shown it to be a beneficial tool when applied clinically. Studies continue to further investigate the causes of aneuploidy, better determine normality, and perhaps one day provide therapy.
Investigators working in this area
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Publications from this area
- PROGNOSTIC VALUE OF BLASTOCYST GRADE AFTER FROZEN EUPLOID EMBRYO TRANSFER IN PATIENTS WITH RECURRENT PREGNANCY LOSS
Gayathree Murugappan G.Kim J Jonathan D.Kort Brent M.Hanson Shelby A.Neal W.Tiegs A K.Osman E Scott RT Lathi R B
F&S ReportsIn press, journal pre-proofAvailable online 9 July 2020 - Clinical error rates of next generation sequencing and array comparative genomic hybridization with single thawed euploid embryo transfer.
Jenna Friedenthal M.Maxwell S W.Tiegs A G. Besser A McCaffrey C Munné S Noyes N A.Grifo J
Eur J Med Genet. 2020 Jan 20:103852. doi: 10.1016/j.ejmg.2020.103852. [Epub ahead of print] - Intracytoplasmic sperm injection is not superior to conventional IVF in couples with non-male factor infertility and preimplantation genetic testing for aneuploidies (PGT-A)
De Munck N El Khatib I Abdala A El-Damen A Bayram A Arnanz A Melado L Lawrenz B Fatemi HM
Hum Reprod. 2020 Feb 29;35(2):317-327. doi: 10.1093/humrep/deaa002. - Term oocyte maturation and term ovarian stimulation: impact on oocyte competence.
Dozortsev DI Pellicer A Diamond MP
Fertil Steril. 2020 Jul 1:S0015-0282(20)30341-1. doi: 10.1016/j.fertnstert.2020.04.013. Online ahead of print. - The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers.
Reig A Franasiak J Scott RT Seli E
J Assist Reprod Genet. 2020 Mar 16. doi: 10.1007/s10815-020-01739-0. [Epub ahead of print] - Human female meiosis checkpoints: how much DNA damage is allowed?
Fragouli E Garrrido N
Fertil Steril. 2020 May;113(5):943-944. doi: 10.1016/j.fertnstert.2020.01.023. Epub 2020 Mar 20. - Mitochondrial DNA content is not predictive of reproductive competence in euploid blastocysts.
Scott RT Sun L Zhan Y Marin D Tao X Seli E
Reprod Biomed Online. 2020 May 14:S1472-6483(20)30193-0. doi: 10.1016/j.rbmo.2020.04.011. Online ahead of print. - Blastocyst mitochondrial DNA (mtDNA) is not affected by oocyte vitrification: a sibling oocyte study.
Arnanz A De Munck N Bayram A El-Damen A Abdalla A ElKhatib I Melado L Lawrenz B Fatemi HM
J Assist Reprod Genet. 2020 Jun;37(6):1387-1397. doi: 10.1007/s10815-020-01795-6. Epub 2020 May 6. - ESHRE PGT Consortium and SIG Embryology good practice recommendations for polar body and embryo biopsy for PGT.
ESHRE PGT Consortium and SIG-Embryology Biopsy Working Group Kokkali G Coticchio G Bronet F Celebi C Cimadomo D Goossens V Liss J Nunes S Sfontouris I Vermeulen N Zakharova E De Rycke M
Hum Reprod Open. 2020 May 29;2020(3):hoaa020. doi: 10.1093/hropen/hoaa020. eCollection 2020. - Interchromosomal effect in carriers of translocations and inversions assessed by preimplantation genetic testing for structural rearrangements (PGT-SR).
Mateu-Brull E Rodrigo L Peinado V Mercader A Campos-Galindo I Bronet F García-Herrero S Florensa M Milán M Rubio C
J Assist Reprod Genet. 2019 Dec;36(12):2547-2555. doi: 10.1007/s10815-019-01593-9. Epub 2019 Nov 6.
- Time of morulation and trophectoderm quality are predictors of a live birth after euploid blastocyst transfer: a multicenter study.
Rienzi L Cimadomo D Delgado A Minasi MG Fabozzi G Gallego RD Stoppa M Bellver J Giancani A Esbert M Capalbo A Remohí J Greco E Ubaldi FM Messeguer M
Fertil Steril. 2019 Dec;112(6):1080-1093.e1. doi: 10.1016/j.fertnstert.2019.07.1322. - Erratum. Worth the wait? Day 7 blastocysts have lower euploidy rates but similar sustained implantation rates as Day 5 and Day 6 blastocysts.
Tiegs AW Sun L Patounakis G Scott RT
Hum Reprod. 2019 Nov 26. pii: dez219. doi: 10.1093/humrep/dez219. [Epub ahead of print] No abstract available. - Interchromosomal effect in carriers of translocations and inversions assessed by preimplantation genetic testing for structural rearrangements (PGT-SR).
Mateu-Brull E Rodrigo L Peinado V Mercader A Campos-Galindo I Bronet F García-Herrero S Florensa M Milán M Rubio C
J Assist Reprod Genet. 2019 Nov 6. doi: 10.1007/s10815-019-01593-9. [Epub ahead of print] - Reply: Careful and expert interpretation of PGT-A data can resolve the mosaicism dilemma.
Lawrenz B El-khatib I Fatemi HM
Hum Reprod. 2019 Nov 11. pii: dez176. doi: 10.1093/humrep/dez176. [Epub ahead of print] No abstract available. - Second-generation preimplantation genetic testing for aneuploidy in assisted reproduction: a SWOT analysis.
Bellver J Bosch E Espinós J García-Velasco JA Fabregues F Fontes J Llácer J Requena A Checa MA
Reprod Biomed Online. 2019 Aug 13. pii: S1472-6483(19)30695-9. doi: 10.1016/j.rbmo.2019.07.037. [Epub ahead of print] Review. - Clinical outcomes after the transfer of blastocysts characterized as mosaic by high resolution Next Generation Sequencing- further insights.
Munné S Spinella F Grifo J Zhang J Beltran MP Fragouli E Fiorentino F
Eur J Med Genet. 2019 Aug 21:103741. doi: 10.1016/j.ejmg.2019.103741. [Epub ahead of print] - Worth the wait? Day 7 blastocysts have lower euploidy rates but similar sustained implantation rates as Day 5 and Day 6 blastocysts.
Tiegs AW Sun L Patounakis G Scott RT
Hum Reprod. 2019 Aug 12. pii: dez138. doi: 10.1093/humrep/dez138. [Epub ahead of print] - mtDNA dynamics between cleavage-stage embryos and blastocysts.
De Munck N Liñan A Elkhatib l Bayram A Arnanz A Rubio C Garrido N Lawrenz B Fatemi HM
J Assist Reprod Genet. 2019 Aug 7. doi: 10.1007/s10815-019-01544-4. [Epub ahead of print] - Preimplantation genetic screening for aneuploidy (PGT-A 2.0) in assisted reproduction: A SWOT analysis
J. Bellver E-Bosch JJ Espinós F.Fabregues J. Fontes J. García-Velasco J. Llácer A. Requena MA Checa
Reproductive BioMedicine Online, In press, journal pre-proof, Available online 16 May 2019 - PGDIS Position Statement on the Transfer of Mosaic Embryos 2019.
Cram DS Leigh D Handyside A Rechitsky L Harton G Grifo J Rubio C Fragouli E Kahraman S Katz-Jaffe M Tempest H Thornhill A Strom C Escudero T Qiao J Munne S Simpson JL Kuliev A
Reprod Biomed Online. 2019 Aug;39 Suppl 1:e1-e4. doi: 10.1016/j.rbmo.2019.06.012. No abstract available. - When next-generation sequencing-based preimplantation genetic testing for aneuploidy (PGT-A) yields an inconclusive report: diagnostic results and clinical outcomes after re biopsy.
Neal SA Sun L Jalas C Morin SJ Molinaro T Scott RT
J Assist Reprod Genet. 2019 Aug 30. doi: 10.1007/s10815-019-01550-6. [Epub ahead of print] - Segmental aneuploidy in human blastocysts: a qualitative and quantitative overview.
Escribà MJ Vendrell X Peinado V
Reprod Biol Endocrinol. 2019 Sep 16;17(1):76. doi: 10.1186/s12958-019-0515-6. - Ovarian Stimulation (OS) Does Not Influence the Uterine Immune Environment in Healthy Infertile Women
D. Alecsandru A. Pacheco A. Guerrero-Mayo A. Fabris P. Aparicio A. Barrio Pellicer A Juan A García-Velasco
Reproductive BioMedicine Online, In press, journal pre-proof, Available online 22 August 2019 - Embryonic aneuploidy rates are equivalent in natural cycles and gonadotropin-stimulated cycles.
Hong KH Franasiak JM Patounakis G Juneau CR Scott RT
Fertil Steril. 2019 Oct;112(4):670-676. doi: 10.1016/j.fertnstert.2019.05.039. - Divining the genetic status of embryos: consult the medium?
Dhruti Babariya D.Phil Megan Leaver M Dagan Wells
Fertility and Sterility, In press, corrected proof,Available online 29 July 2019 - Cleavage stage mitochondrial DNA is correlated with preimplantation human embryo development and ploidy status.
Bayram A De Munck N Elkhatib I Arnanz A Liñán A Lawrenz B Fatemi HM
J Assist Reprod Genet. 2019 Jul 10. doi: 10.1007/s10815-019-01520-y. [Epub ahead of print] - Embryonic Aneuploidy after Preimplantation Genetic Screening: Age- and Indication-Matched Comparative Study between Indian and Spanish Population.
Kotdawala A Mir P Herrero J Khajuria R Lalitkumar PGL Banker MR
J Hum Reprod Sci. 2019 Apr-Jun;12(2):141-149. doi: 10.4103/jhrs.JHRS_109_18. - Transcriptomic behavior of genes associated with chromosome 21 aneuploidies in early embryo development.
Sanchez-Ribas I Diaz-Gimeno P Sebastián-León P Mercader A Quiñonero A Ballesteros A Pellicer A Domínguez F
Fertil Steril. 2019 May;111(5):991-1001.e2. doi: 10.1016/j.fertnstert.2019.01.023. Epub 2019 Mar 25 - The clinicians´ dilemma with mosaicism-an insight from inner cell mass biopsies.
Lawrenz B El Khatib I Liñán A Bayram A Arnanz A Chopra R De Munck N Fatemi HM
Hum Reprod. 2019 May 22. pii: dez055. doi: 10.1093/humrep/dez055. [Epub ahead of print] - The preimplantation genetic testing debate continues: first the hype, then the tension, now the hypertension?
Patounakis G Hill MJ
Fertil Steril. 2019 May 27. pii: S0015-0282(19)30407-8. doi: 10.1016/j.fertnstert.2019.04.028. [Epub ahead of print] No abstract available. - Gene Editing Should Replace Embryo Selection Following PGD.
Wells D Vermeesch JR Simpson JL
Prenat Diagn. 2019 Mar 4. doi: 10.1002/pd.5442. [Epub ahead of print] No abstract available. - Mitochondria as a Biomarker for IVF Outcome.
Kim J Seli E
Reproduction. 2019 Mar 1. pii: REP-18-0580.R2. doi: 10.1530/REP-18-0580. [Epub ahead of print] Review. - Mitochondrial DNA copy number as a predictor of embryo viability.
Cecchino GN Garcia-Velasco JA
Fertil Steril. 2019 Feb;111(2):205-211. doi: 10.1016/j.fertnstert.2018.11.021. Epub 2019 Jan 2. Review. - Mosaic embryos present a challenging clinical decision.
Osman EK Werner MD
Fertil Steril. 2019 Jan;111(1):52-53. doi: 10.1016/j.fertnstert.2018.10.032. No abstract available. - The cytogenetic constitution of human blastocysts: insights from comprehensive chromosome screening strategies.
Fragouli E Munne S Wells D
Hum Reprod Update. 2019 Jan 1;25(1):15-33. doi: 10.1093/humupd/dmy036. - The model of "genetic compartments": a new insight into reproductive genetics.
Vendrell X Escribà MJ
J Assist Reprod Genet, NA:NA-NA, 2018. - Preimplantation genetic testing for aneuploidy is cost-effective, shortens treatment time, and reduces the risk of failed embryo transfer and clinical miscarriage.
Neal SA Morin SJ Franasiak JM Goodman L Juneau CR Forman EJ Werner MD Scott RT
Fertil Steril, 110(5):896-904, 2018. - Quest for a less invasive approach to preimplantation genetic testing remains ongoing
Neal SA Werner MD
Fertil Steril, 110(5):854-856, 2018. - Minimizing mosaicism: assessing the impact of fertilization method on rate of mosaicism after next-generation sequencing (NGS) preimplantation genetic testing for aneuploidy (PGT-A).
Palmerola KL Vitez SF Amrane S Fischer CP Forman EJ
J Assist Reprod Genet, NA:NA-NA, 2018. - The model of "genetic compartments": a new insight into reproductive genetics.
Vendrell X Escribà MJ
J Assist Reprod Genet, doi: 10.1007/s10815-018-1366-3.2018 - The Status of Genetic Screening in Recurrent Pregnancy Loss.
Kaser DJ
Obstet Gynecol Clin North Am, 45(1):143-154, 2018. - What to do when good-quality embryos repeatedly fail to implant.
Coughlan C
Best Pract Res Clin Obstet Gynaecol, 53:48-59, 2018. - Pregnancy after vasectomy: surgical reversal or assisted reproduction?
Valerie U De Brucker S De Brucker M Vloeberghs V Drakopoulos P Santos-Ribeiro S Tournaye H
Tournaye H.Hum Reprod, 1;33(7):1218-27, 2018. - Does the type of GnRH analogue used, affect live birth rates in women with endometriosis undergoing IVF/ICSI treatment, according to the rAFS stage?
Drakopoulos P Rosetti J Pluchino N Blockeel C Santos-Ribeiro S de Brucker M Drakakis P Camus M Tournaye H Polyzos NP
Gynecol Endocrinol, 12:1-6, 2018. - Premature progesterone elevation: targets and rescue strategies.
Lawrenz B Labarta E Fatemi HM Bosch E
Fertil Steril, 109(4):577-582, 2018. - The impact of contemporary preimplantation genetic screening and diagnosis on the detection of aneuploidy and inherited genetic diseases.
Neal SA Werner MD
Birth Defects Res, 110(8):644-647, 2018. - Next generation sequencing for preimplantation genetic testing for aneuploidy: friend or foe?
Fragouli E
Fertil Steril, 109(4):606-607, 2018. - Very low anti-müllerian hormone concentrations are not an independent predictor of embryo quality and pregnancy rate.
Pacheco A Cruz M Iglesias C García-Velasco JA
Reprod Biomed Online, 37(1):113-119, 2018. - Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos.
Wang T Babayev E, Jiang Z Li G Zhang M Esencan E Horvath T Seli E
Aging Cell, 30:e12784. doi: 10.1111/acel.12784, 2018. - Veratridine-sensitive Na+ channels regulate human sperm fertilization capacity.
Candenas L Pinto FM Cejudo Román A González-Ravina C Fernández-Sánchez M Pérez-Hernández Irazusta J Subirán N
Life Sci, 196:48-55, 2018. - Cumulus cell transcriptome profiling is not predictive of live birth after in vitro fertilization: a paired analysis of euploid sibling blastocysts.
Green KA Franasiak JM Werner MD Tao X Landis JN Scott RT Treff NR
Fertil Steril, 109(3):460-466, 2018. - The Status of Genetic Screening in Recurrent Pregnancy Loss.
Kaser DJ
Obstet Gynecol Clin North Am, 45(1):143-154. doi: 10.1016/j.ogc.2017.10.007, 2018. - Validation of a targeted next generation sequencing-based comprehensive chromosomescreening platform for detection of triploidy in human blastocysts.
Marin D Zimmerman R Tao X Zhan Y Scott RT Treff NR
Reprod Biomed Online, 36(4):388-395, 2018. - Risk of pelvic inflammatory disease after intrauterine insemination: a systematic review.
Matorras R Rubio K Iglesias M Vara I Expósito A.
Hum Reprod, 36(2):164-171. doi: 10.1016/j.rbmo.2017.11.002, 2018, - Unexpected repeat immature oocyte response after IVF stimulation: a case report.
Mishra V Chirumamilla L
Gynecol Endocrinol, 34(2):100-102. doi: 10.1080/09513590.2017.1369514, 2018. - The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology.
Moreno I Cicinelli E Garcia-Grau I Gonzalez M Bau D Vilella F Ziegler D Resta L Valbuena D Simón C
Am J Obstet Gynecol, 218(6):602-602, 2018. - Three-Dimensional Angiogenic Evaluation of the Effect of Mifepristone in early gestation: pilot study
Pellicer-Iborra B Herraiz S Morales A Martínez S Garrido N Pellicer A
Gynecol Obstet, 7:90932,1000451, 2018. - NGS Analysis of Human Embryo Culture Media Reveals miRNAs of Extra Embryonic Origin.
Sanchez-Ribas I Díaz-Gimeno P Quiñonero A Ojeda M Larreategui Z Ballesteros A Domínguez F
Reprod Sci, NA:NA-NA, 2018. - Origin and composition of cell-free DNA in spent medium from human embryo culture during preimplantation development.
Vera-Rodriguez M Diez-Juan A Jimenez-Almazan J Martínez S Navarro R Peinado V Mercader A Meseguer M Blesa D Moreno I Valbuena D Rubio C Simón C
Hum Reprod, 33(4):745-756, 2018. - Validation of a targeted next generation sequencing-based comprehensive chromosomescreening platform for detection of triploidy in human blastocysts.
Marin D Zimmerman R Tao X Zhan Y Scott RT Treff NR
Reprod Biomed Online, pii: S1472-6483(17)30710-1. doi: 10.1016/j.rbmo.2017.12.015, 2018. - Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the IVF population
Juneau C Kraus E Werner MD Franasiak JM Morin SJ Patounakis G Molinaro T de Ziegler D Scott RT
Fertil Steril, 108: 284-288, 2017. - Detection of mosaicism at blastocyst stage with the use of high-resolution next-generation sequencing.
Munné S Wells D
Fertil Steril, 107:1085–1091, 2017. - Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the in vitro fertilization population.
Juneau C Kraus E Werner MD Franasiak JM Morin SJ Patounakis G Molinaro T De Ziegler D Scott RT
Fertil Steril, 108(2):284-288, 2017. - Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.
Zhang J Liu H Luo S Lu Z Chávez-Badiola A Liu Z Yang M Merhi Z Silber SJ Munné S Konstandinidis M Wells D Huang T
Reprod Biomed Online, 34:361-368, 2017. - Detailed investigation into the cytogenetic constitution and pregnancy outcome of replacing mosaic blastocysts detected with the use of high-resolution next-generation sequencing.
Munné S Blazek J Large M Martinez-Ortiz PA Nisson H Liu E Tarozzi N Borini A Becker A Zhang J Maxwell S Grifo J Babariya D Wells D Fragouli E
Fertil Steril, 108:62-71, 2017. - Karyomapping: a single centre experience from application of methodology to ongoing pregnancy and live-birth rates.
Ben-Nagi J Wells D Doye K Exeter H Drew E Alfarawati S Naja R Serhal P Loutradi K
Reprod Biomed Online, 35:264–271, 2017. - Mitochondrial DNA Quantification- the devil in the detail
Wells D Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munné S Fragouli E
Hum Reprod, 32:2150–2151, 2017. - Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts.
Fragouli E Alfarawati S Spath K Babariya D Tarozzi N Borini A Wells D
Hum Genet, 136: 805-819, 2017 - Type of chromosome abnormality affects embryo morphology dynamics.
Del Carmen Nogales M Bronet F Basile N Martínez EM Liñán A Rodrigo L Meseguer M
Fertil Steril, 107(1):229-235, 2017. - In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study.
Rubio C Bellver J Rodrigo L Castillón G Guillén A Vidal C Giles J Ferrando M Cabanillas S Remohí J Pellicer A Simón C
Fertil Steril. 2017 May;107(5):1122-1129. doi: 10.1016/j.fertnstert.2017.03.011. Epub 2017 Apr 19. - High relative deoxyribonucleic acid content of trophectoderm biopsy adversely affects pregnancy outcomes.
Neal SA Franasiak JM Forman EJ Werner MD Morin SJ Tao X Treff NR Scott RT
Fertil Steril, 107(3):731-736, 2017. - Crossing the germline: CRISPR-Cas9 and our responsibility as reproductive endocrinology and infertility physicians.
Kaser DJ Franasiak JM
J Assist Reprod Genet. 2018 Mar;35(3):399-402. doi: 10.1007/s10815-017-1075-3. Epub 2017 Oct 30. - Reply: Detecting mosaicism in trophectoderm biopsies.
Capalbo A Ubaldi F Rienzi L Scott RT Treff N
Hum Reprod. 2017 Mar 1;32(3):714-715. doi: 10.1093/humrep/dew347. No abstract available. - Abnormally fertilized oocytes can result in healthy live births: improved genetic technologies for preimplantation genetic testing can be used to rescue viable embryos in in vitro fertilization cycles
Capalbo A Treff N Cimadomo D Tao X Ferrero S Vaiarelli A Colamaria S Maggiulli R Orlando G Scarica C Scott RT Ubaldi FM Rienzi L
Fertil Steril. 2017 Sep 15. pii: S0015-0282(17)31699-0. doi: 10.1016/j.fertnstert.2017.08.004. [Epub ahead of print - Genomic instability during reprogramming by nuclear transfer is DNA replication dependent.
Chia G Agudo J Treff N Sauer MV Billing D Brown BD Baer R Egli D
Nat Cell Biol. 2017 Apr;19(4):282-291. doi: 10.1038/ncb3485. Epub 2017 Mar 6. - Spermatozoa with numerical chromosomal abnormalities are more prone to be retained by Annexin V-MACS columns.
Esbert M Godo A Soares SR Florensa M Amorós D Ballesteros A Vidal F
Andrology. 2017 Jun 14. doi: 10.1111/andr.12376. [Epub ahead of print] - Evaluation of comprehensive chromosome screening platforms for the detection of mosaic segmental aneuploidy.
Goodrich D Xing T Tao X Lonczak A Zhan Y Landis J Zimmerman R Scott RT Treff NR
J Assist Reprod Genet. 2017 Jun 2. doi: 10.1007/s10815-017-0924-4. [Epub ahead of print] - Continuing to deliver: the evidence base for pre-implantation genetic screening.
Griffin DK Fishel S Gordon T Yaron Y Grifo J Hourvitz A Rechitsky S Elson J Blazek J Fiorentino F Treff N Munne S Leong M Schmutzler A Vereczkey A Ghobara T Nánássy L Large M Hamamah S Anderson R Gianaroli L Wells D
BMJ. 2017 Feb 14;356:j752. doi: 10.1136/bmj.j752. No abstract available - Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the in vitro fertilization population.
Juneau C Kraus E Werner MD Franasiak JM Morin SJ Patounakis G Molinaro T De Ziegler D Scott RT
Fertil Steril. 2017 Jun 23. pii: S0015-0282(17)30421-1. doi: 10.1016/j.fertnstert.2017.05.038. [Epub ahead of print] - A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of EuploidEmbryos.
Labarta E Bosch E Mercader A Alamá P Mateu E Pellicer A
Biomed Res Int. Received 13 November 2016; Accepted 23 February 2017; Published 27 March 2017 - Corrigendum to "A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of Euploid Embryos".
Labarta E Bosch E Mercader A Alama P Mateu E Pellicer A
Biomed Res Int. 2017;2017:1718068. doi: 10.1155/2017/1718068. Epub 2017 Jul 13. - Comprehensive chromosome screening and gene expression analysis from the same biopsy in human preimplantation embryos.
Marin D Wang Y Tao X Scott RT Treff NR
Mol Hum Reprod. 2017 May 1;23(5):330-338. doi: 10.1093/molehr/gax014 - Preimplantation embryonic mosaicism: origin, consequences and the reliability of comprehensive chromosome screening.
Marin D Scott RT Treff NR
Curr Opin Obstet Gynecol. 2017 Jun;29(3):168-174. doi: 10.1097/GCO.0000000000000358. - Identification and characterization of Aurora Kinase B and C variants associated with maternal aneuploidy.
Nguyen AL Marin D Zhou A Gentilello AS Smoak EM Cao Z Fedick A Wang Y Taylor D Scott RT Xing J Treff N Schindler K
Mol Hum Reprod. 2017 Mar 25. doi: 10.1093/molehr/gax018. [Epub ahead of print] - In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study.
Rubio C Bellver J Rodrigo L Castillón G Guillén A Vidal C Giles J Ferrando M Cabanillas S Remohí J Pellicer A Simón C
Fertil Steril. 2017 May;107(5):1122-1129. doi: 10.1016/j.fertnstert.2017.03.011. Epub 2017 Apr 19. - Introduction: Subchromosomal abnormalities in preimplantation embryonic aneuploidy screening.
Scott RT
Fertil Steril. 2017 Jan;107(1):4-5. doi: 10.1016/j.fertnstert.2016.11.017 - Advances in Preimplantation Genetic Testing for Monogenic Disease and Aneuploidy.
Treff NR Zimmerman RS.
Annu Rev Genomics Hum Genet. 2017 May 12. doi: 10.1146/annurev-genom-091416-035508. [Epub ahead of print] - Assessment of embryo morphology and developmental dynamics by time-lapse microscopy: is there a relation to implantation and ploidy?
Zaninovic N Irani M Meseguer M
Fertil Steril. 2017 Nov;108(5):722-729. doi: 10.1016/j.fertnstert.2017.10.002. Review. - Detection of segmental aneuploidy and mosaicism in the human preimplantation embryo: technical considerations and limitations.
Treff N Franasiak JM
Fertil Steril, 107:27-31 - Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe. J Glob Oncol. 4, pp. 1 - 16. 28/06/2017.
Rashedi AS de Roo SF Ataman LM Edmonds ME Silva AA Scarella A Horbaczewska A Anazodo A Arvas A Ramalho de Carvalho B Sartorio C Beerendonk CCM Diaz-Garcia C
- Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy.
Ravichandran K Guzman L Escudero T Zheng X Colls P Jordan A Cohen J Wells D Munné S
Reprod Biomed Online, 33:550–559, 2016. - The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.
Sermon K Capalbo A Cohen J Coonen E De Rycke M De Vos A Delhanty J Fiorentino F Gleicher N Griesinger G Grifo J Handyside A Harper J Kokkali G Mastenbroek S Meldrum D Meseguer M Montag M Munné S Rienzi L Rubio C Scott KScott RT Simón C Swain J Treff N Ubaldi F Vassena R Vermeesch J Verpoest W Wells D Geraedts J
Mol Hum Reprod, 22:845–857, 2016. - Why do euploid embryos miscarry? A case-control study comparing the rate of aneuploidy within presumed euploid embryos that resulted in miscarriage or live birth using next-generation sequencing.
Maxwell SM Colls P Hodes-Wertz B McCulloh DH McCaffrey C Wells D Munné S Grifo J
Fertil Steril, 106:1414-1419, 2016. - Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.
Enciso M Sarasa J Xanthopoulou L Bristow S Bowles M Fragouli E Delhanty J Wells D
Hum Genet, 135:555–568, 2016. - Preimplantation genetic diagnosis: an overview and recent advances.
Ben-Nagi J Serhal P SenGupta S Doye K Wells D
Obstet Gynaecol, 18:99–106, 2016. - Current controversies in prenatal diagnosis 4: preimplantation genetic screening should be routinely offered to all preimplantation genetic diagnosis cases.
Harper J Wells D Simpson JL
Prenat Diagn, 36:25–28, 2016. - Mosaicism: “survival of the fittest” versus “no embryo left behind”.
Munné S Grifo J Wells D
Fertil Steril, 105:1146–1149, 2016. - Preimplantation genetic diagnosis for infertility.
Wells D Lewin J
In Textbook of Assisted Reproductive technologies, 5th Edition (Informa Healthcare, UK), p346-353. Edited by Gardner D, Weissman A, Howles C, Shoham Z. 2016. - Embryonic aneuploidy does not differ among genetic ancestry according to continental origin as determined by ancestry informative markers.
Franasiak JM Olcha M Shastri S Molinaro T Congdon H Treff NR Scott RT
HumReprod, 31(10):2391-5, 2016 - Kinetics of the early development of uniparental human haploid embryos.
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J Hum Reprod Sci, 9(4):223-229, 2016. - The challenge of embryonic mosaicism in preimplantation genetic screening.
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Rev Iberoam Fert Rep Hum, 33: 67-72, 2016. - Automatic time-lapse instrument is superior to single-point morphology observation for selecting viable embryos: retrospective study in oocyte donation.
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Hum Reprod 31:2391-5, 2016. - Challenges facing contemporary preimplantation genetic screening.
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Curr Opin Obstet Gynecol 28:151-7, 2016. - Preimplantation genetic screening - what a wonderful world it would be!
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Reprod Biomed Online. 32:337-8. 2016. - Pathophysiologic processes have an impact ot the plasma metabolomics signature of endometriosis patients.
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Fertil Steril, 106 (7): 1733-1741. E1, 2016. - A randomized and blinded comparison of qpcr and NGS based detection of aneuploidy in a cell line mixture model of blastocyst biopsy mosaicism.
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Human Reprod, 30(2);276-83, 2015. - SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts.
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J Assist Reprod Genet, 33:1115-9, 2016. - Next Generation Sequencing Based Comprehensive Chromosome Screening in Mouse Polar Bodies, Oocytes, and Embryos.
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Biol Reprod, 94:76, 2016. - Development and validation of concurrent preimplantation genetic diagnosis for single gene disorders and comprehensive chromosomal aneuploidy screening without whole-genome amplification.
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Curr Opin Obstet Gynecol. 2015. - Karyomapping allows preimplantation genetic diagnosis of a de-novo deletion undetectable using conventional PGD technology.
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Reprod Biomed Online, 31:770–775, 2015. - Live births following Karyomapping of human blastocysts: experience from clinical application of the method.
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Reprod Biomed Online, 31:1–3, 2015. - Karyomapping - a comprehensive means of simultaneous monogenic and cytogenetic PGD: comparison with standard approaches in real time for Marfan syndrome.
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J Assist Reprod Genet, 32:347–356, 2015. - Routine use of next-generation sequencing for preimplantation genetic diagnosis of blastomeres obtained from embryos on day 3 in fresh in~vitro fertilization cycles.
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Fertil Steril, 103:1031–1036, 2015. - Comprehensive carrier genetic test using next-generation deoxyribonucleic acid sequencing in infertile couples wishing to conceive through assisted reproductive technology
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Hum Reprod Update, 21(1):153-4, 2015 - Endometrial Microbiome at the Time of Embryo Transfer: Next Generation Sequencing of the 16s Ribosomal Subunit.
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J Assist Reprod Genet 33:129-36, 2015. - Discordant embryonic aneuploidy testing and prenatal ultrasonography prompting androgen insensitivity syndrome diagnosis.
Franasiak JM Yao X Ashkindaze E Rosen T Scott RT
Obstet Gynecol 125:383-6, 2015. - Comprehensive chromosome screening improves embryo selection: a meta-analysis.
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Fertil Steril. 104:1503-12, 2015. - Preimplantation genetic screening using comprehensive chromosome screening: evidence and remaining challenges.
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Hum Reprod. 30:1515-6, 2015. - The time to prevent mendelian genetic diseases from donated or own gametes has come.
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Hum Reprod Update, 21:727-747, 2015. - The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening.
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Fertil Steril 2014;101(3):656–663.e1. - Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform.
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Fertil Steril, 102:1385–1392, 2014. - Live birth after PGD with confirmation by a comprehensive approach (karyomapping) for simultaneous detection of monogenic and chromosomal disorders.
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Reprod Biomed Online, 29:600–605, 2014. - Human embryonic aneuploidy.
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Encyclopedia of Life Sciences, Online, 2014. - Clinical utilization of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation.
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J Med Genet, 51:553–562, 2014. - Telomere length and aneuploidy: clinical and biological insights into human preimplantation embryos.
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Reprod Biomed Online, 28:531–532, 2014. - Next-generation sequencing: the dawn of a new era for preimplantation genetic diagnostics.
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Fertil Steril, 101:1250–1251, 2014. - Role of statins in PCOS management
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Chapter 11, pp 181-203. Editor: Lubna Pal. Springer, 2014. - Live birth after embryo transfer in an unresponsive thin endometrium.
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Trends Mol Med 20:499-508, 2014. - Clinical genetic testing for male factor infertility: current applications and future directions.
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Eur J Hum Genet, 23:901-6, 2014 - Polar body based aneuploidy screening is poorly predictive of embryo ploidy and reproductive potential.
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J Assist Reprod Genet, 31:1221-6, 2014. - Improved sensitivity to detect recombination using qPCR for Dyskeratosis Congenita PGD.
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JARG, 31:1227-30, 2014 - Obstetrical and neonatal outcomes from the BEST Trial: Single embryo transfer with aneuploidy screening improves outcomes after in vitro fertilization without compromising delivery rates.
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Am J Obstet Gynecol, 210:157, 2014. - Uniparental disomy in the human blastocyst is exceedingly rare.
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Clin Chem, 60:25-8, 2014. - To preserve or not to preserve: How difficult is the decision about fertility preservation?
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Cancer. 2013 Nov 15;119(22):4044-50. - Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis.
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J Clin Endocrinol Metabol, 2013. - Treatment of Luteal Phase Defects in Assisted Reproduction.
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Curr Drug Targets. Jul; 14(8):832-42, 2013. - Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials.
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Hum Genet, 132:1001–1013, 2013. - Questions about the accuracy of polar body analysis for preimplantation genetic screening.
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Am J Obstet Gynecol, 210:157.e1-6, 2013. - Additive effect of factors related to assisted conception on the reduction of maternal serum pregnancy-associated plasma protein A concentrations and the increased false-positive rates in first-trimes
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Fertil Steril, 100:1314-1320.e3, 2013. - False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3.
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J Assist Reprod Genet, 30 (1); 143-9, 2013. - Selecting the optimal time to perform biopsy for preimplantation genetics
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Fertil Steril, 100: 608-614, 2013. - Incidental identification of balanced translocation carrier patients through comprehensive chromosome screening of IVF-derived blastocysts.
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J Assist Reprod Genet, 30:787-91, 2013. - Next-generation sequencing for preimplantation genetic diagnosis. Letter to the Editor.
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Fertil Steril, 99:e17-18, 2013 - Evaluation of targeted next-generation sequencing based preimplantation genetic diagnosis of monogenic disease.
Treff NR Fedick A Tao X Devkota B Taylor D Scott RT
Fertil Steril, 99:1377-1384, 2013. - Four-hour quantitative real-time polymerase chain reaction– based comprehensive chromosome screening and accumulating evidence of accuracy, safety predictive values and clinical efficacy.
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Fertil Steril, 99: 1049-1053, 2013. - Embryos whose polar bodies contain isolated reciprocal chromosome aneuploidy are almost always euploid.
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Hum Reprod, 28:502-8, 2013. - Sperm DNA fragmentation index does not correlate with the sperm or embryo aneuploidy rate in recurrente miscarriage or implantation failure patients.
Bronet F Martínez E Gaytan M Liñán A Cernuda D Ariza M Nogales M Pacheco A San celestino M García-Velasco JA
Hum Reprod 27: 1922-9, 2012 - Characteristics of chromosomal abnormalities diagnosed after spontaneous abortions in an infertile population.
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J Assist Reprod Genet. May 2012. J Assist Reprod Genet. August 2012; 29 (8); 817-20. - Successful Live Birth following Preimplantation Genetic Diagnosis for Phenylketonuria in Day 3 Embryos by Specific Mutation Analysis and Elective Single Embryo Transfer.
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JIMD Reports, 7:49–54, 2012. - Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLC?) from an infertile man by use of minisequencing of individual sperm and expression in somatic
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Fertil Steril, 98:423–431, 2012. - Alteration of gene expression in human cumulus cells as a potential indicator of oocyte aneuploidy.
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Hum Reprod, 27:2559–2568, 2012. - Aneuploidy Screening for Embryo Selection.
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Semin Reprod Med, 30:289–301, 2012. - Transcriptomic analysis of follicular cells provides information on the chromosomal status and competence of unfertilized oocytes.
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Expert Rev Mol Diagn, 12:1–4, 2012. - Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes.
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Fertil Steril, 97:935–942, 2012. - Preimplantation genetic diagnosis (PGD), preimplantation genetic screening (PGS) and the transfer of in vitro fertilized embryos.
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Hum Reprod, 27:1922-29, 2012 - Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS.
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J Assist Reprod Genet. 29:249-53, 2012. - Hepatitis B virus in human oocytes and embryos
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Hum Reprod, 27:1227-1228, 2012. - Consistent and predictable delivery rates after oocyte vitrification: an observationallongitudinal cohort multicentric study.
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Hum Reprod, 13(3):409-16; 2012. - Chromosomal abnormalities in embryos from couples with a previous aneuploid miscarriage.
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Fertil Steril, 98(1);145-50, 2012. - Comprehensive chromosome screening and embryo selection: moving toward single euploid blastocyst transfer.
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Semin Reprod Med, 30:236-42, 2012. - Methods for comprehensive chromosome screening of oocytes and embryos: capabilities, limitations, and evidence of validity.
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J Assist Reprod Genet, 29:381-90, 2012 - Delivery of a chromosomally normal child from an oocyte with reciprocal aneuploid polar bodies.
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J Assist Reprod Genet, 29:533-7, 2012. - Blastocyst preimplantation genetic diagnosis of a mitochondrial DNA disorder.
Treff NR Tao X Campos J Su J Ferry KM Levy B Scott RT
Fertil Steril, 98:1236-1240, 2012. - Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study.
Scott RT Ferry KM Su J Tao X Scott KL Treff NR
Fertil Steril, 97:870-875, 2012. - Development and validation of an accurate quantitative real-time polymerase chain reaction – based assay for human blastocyst comprehensive chromosomal aneuploidy screening. Seminal Contribution.
Treff NR Tao X Ferry KM Su J Taylor D Scott RT
Fertil Steril, 97:819-824, 2012. - Single embryo transfer with comprehensive chromosome screening results in improved ongoing pregnancy rates and decreased miscarriage rates.
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Human Reproduction, 27:1217- 22, 2012. - Self-correction in tripronucleated human embryos.
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Fertil Steril, 96(4):951-6, 2011. - A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC?) leads to male infertility.
Kashir J Konstantinidis M Jones C Lemmon B Lee HC Hamer R Heindryckx B Deane CM De Sutter P Fissore RA Parrington J Wells D Coward K
Hum Reprod, 27:222–231, 2011. - The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy.
Fragouli E Alfarawati S Goodall N Sanchez-Garcia JF Colls P Wells D
Mol Hum Reprod, 17:286–295, 2011. - First births after preimplantation genetic diagnosis of structural chromosome abnormalities using comparative genomic hybridization and microarray analysis.
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Hum Reprod, 26:1560–1574, 2011. - Chromosome Abnormalities in the Human Oocyte.
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Cytogenet Genome Res, 133:107–118, 2011 - PGD and aneuploidy screening for 24 chromosomes: advantages and disadvantages of competing platforms.
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Reprod Biomed Online, 23:677–685, 2011. - Aneuploidy in the Human Blastocyst
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Cytogenet Genome Res, 133:149–159, 2011. - Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos.
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Fertil Steril, 95:953–958, 2011. - Therapeutic treatments of mtDNA diseases at the earliest stages of human development.
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Mitochondrion, 11:820–828, 2011. - Cumulative live-birth rates per total number of embryos needed to reach newborn in consecutive in vitro fertilization (IVF) cycles: a new approach to measuring the likelihood of IVF success.
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Fertil Steril, 96:40-46, 2011. - Effect of sperm DNA fragmentation on pregnancy outcome depends on oocyte quality
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Fertil Steril, 95:124-128, 2011. - Fertility after age 45: From natural conception to assisted reproductive technology and beyond.
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Maturitas, 70:216-221, 2011. - Telomere DNA deficiency is associated with development of human embryonic aneuploidy.
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PLoS Genetics, 7: e1002161, 2011 - SNP Microarray Based Concurrent Screening of 24 Chromosome Aneuploidy and Unbalanced Translocations in Preimplantation Human Embryos.
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Fertil Steril, 95:1606-1612, 2011. - Surgical management of tubal disease and infertility
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Obstetrics, Gynaecology and Reproductive Medicine, Vol 19, 2010. - Blood group and ovarian hyperstimulation syndrome.
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Fertil Steril, 93:270-1, 2010. - Accurate single cell 24 chromosome aneuploidy screening using whole genome amplification and single nucleotide polymorphism microarrays.
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Fertil Steril, 94: 2017-2021, 2010. - GnRH agonist administration at the time of implantation does not improve pregnancy outcome in intrauterine insemination cycles: a randomized controlled tria
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Rev Int Androl 8: 107-13, 2010 - Cytogenetic analysis of human blastocysts with the use of FISH, CGH and aCGH: scientific data and technical evaluation.
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Hum Reprod, 26:480–490, 2010. - Transmission of Mitochondrial DNA Diseases and Ways to Prevent Them.
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PLoS Genet, 6, 2010. - Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes.
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Journal of Reproductive Medicine and Endocrinology, 7:236-239, 2010 - Embryo aneuploidy and the role of morphological and genetic screening.
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Mol Hum Reprod, 16:570–582, 2010. - Improved detection of aneuploid blastocysts using a new 12-chromosome FISH test.
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Reprod Biomed Online, 20:92–97, 2010. - Y chromosome microdeletions, sperm DNA fragmentation and sperm oxidative stress as causes of recurrent spontaneous abortion of unknown etiology.
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Hum Reprod, 25:1713-1721, 2010. - Improving FISH diagnosis for preimplantation genetic aneploidy screening
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Human Reprod, 25(7); 1812-7, 2010. - Aneploidies in embryos and spermatozoa from patients with Y chromosome microdelections.
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Reprod Biomed Online, 21(5); 649-57, 2010. - Single Cell Whole Genome Amplification Technique Impacts the Accuracy of SNP Microarray Based Genotyping and Copy Number Analyses.
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Mol Hum Repro, 17: 335–343, 2010. - SNP microarray based 24 chromosome aneuploidy screening demonstrates that cleavage stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts.
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Mol Hum Repro, 16:590-600, 2010. - SNP microarray based 24 chromosome aneuploidy screening is significantly more consistent than FISH.
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Mol Hum Repro, 16:583-9, 2010. - Assessing the reproductive competence of individual embryos: a proposal for the validation of new "-omics" technologies.
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Fertil Steril, 94:791-794, 2010. - Robust embryo identification using polar body single nucleotide polymorphism microarray based DNA fingerprinting.
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Fertil Steril, 93: 2453-2455, 2010. - The p53 codon 72 single nucleotide polymorphism lacks a significant effect on implantation rate in fresh in vitro fertilization cycles: an analysis of 1,056 patients.
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Fertil Steril, 92:1290-6. 2009. - Comparative genomic hybridization of oocytes and first polar bodies from young donors.
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Reprod Biomed Online, 19:228–237, 2009. - Vitrification of preimplantation genetically diagnosed human blastocysts and its contribution to the cumulative ongoing pregnancy rate per cycle by using a closed device
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Fertil Steril, 89(4):840-6, 2008 - Técnica de B-Lynch en el control de la hemorragia posparto Progresos de Obstetricia
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Ginecología Volumen 51,(9), 513-519, 2008. - Birth of a healthy boy after a double factor PGD in a couple carrying a genetic disease and at risk for aneuploidy.
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Hum Reprod, 23:1949–1956, 2008. - Evaluation of embryo quality by Metabolomics: A new strategy to aid single embryo transfer.
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J Mammal Ova Res. 25:26-31, 2008. - Soluble vascular endothelial-cadherin levels correlate with clinical and biological aspects of severe ovarian hyperstimulation syndrome.
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Hum Reprod. 23:662-7, 2008. - Artículo de revisión "Diagnóstico por imagen”
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Cuadernos de Medicina Reproductiva, 13( 2) : 37-51, 2007. - Sperm selection by swim-up in terms of deoxyribonucleic acid fragmentation as measured by the sperm chromatin dispersion test is altered in heavy smokers.
Viloria T Garrido N Fernández JL Remohí J Pellicer A Meseguer M
Fertil Steril, 88:523-525, 2007. - Single cell diagnosis using comparative genomic hybridization after preliminary DNA amplification still needs more tweaking: too many miscalls.
Fragouli E Delhanty JD Wells D
Fertil Steril, 88:247–248, 2007. - J.Ultrastructure of preimplantation genetic diagnosis-derived human blastocysts grown in a coculture system after vitrification.
Escribà MJ Escobedo-Lucea C Mercader A De Los Santos MJ Pellicer A Remohí J
Fertil Steril, 86(3):664-71, 2006 - Heteroparental blastocyst production from microsurgically corrected tripronucleated human embryos.
Escribà MJ Martín J Rubio C Valbuena D Remohí J Pellicer A Simón C
Fertil Steril, 86(6):1601-7, 2006. - Prenatal management of placental chorioangioma: value of the middle cerebral artery peak systolic velocity.
Escribano D Galindo A Arbués J Puente J De la Fuente P
Fetal Diagn Ther, 21(6):489-93, 2006. - Use of Real-Time Polymerase Chain Reaction to Measure Gene Expression in Single Cells.
Wells D
In Single Cell Diagnostics: Methods and Protocols (Humana Press, USA), p125-134. Edited by Thornhill, A. 2006. - A successful strategy for Preimplantation Genetic Diagnosis of betathalassemia and simultaneous detection of Down's syndrome using multiplex fluorescent PCR.
Piyamongkol W Vutyavanich T Piyamongkol S Wells D Kunaviktikul C Tongsong T Chaovisitsaree S Saetung R Sanguansermsri T
J Med Assoc Thai, 89:918-27, 2006. - Estudio comparativo de dos medios de cultivo HTF e ISM-1: implicaciones en el fenotipo embrionario y resultados clínicos.
Gimeno L Lopez MA Meseguer M Santos JM Pellicer A Remohí J Santos MJ
Revista Iberoamericana de Fertilidad y Reproducción Humana, 23: 375-382, 2006. - Etiologia, diagnostico y manejo del hidrops fetal: revision de 140 casos
Arbués J Galindo A Puente J Grañeras A De la Fuente P
Prog Obstet Ginecol 48:225-230, 2005. - Isolated unilateral pulmonary agenesis. Early prenatal diagnosis and long-term follow up.
Arbués J Galindo A Rasero M Orbea C Puente J De la Fuente P
J Ultrasound Med, 24: 865-8, 2005. - The singleton, term gestation, and live birth rate per cycle initiated: a 1-year experience in in vitro fertilization cycles with native and donated oocytes.
Bellver J Albert C Soares SR Alvarez C Pellicer A
Fertil Steril, 83:1404-9, 2005. - Near Speed-of-Light On-Chip Interconnects Using Pulsed Current-Mode Signaling.
Jose AP Patounakis G Shepard KL
2005 Symposium on VLSI Circuits, 108-11. 2005. - Association of abnormal morphology and altered gene expression in human preimplantation embryos.
Wells D Bermúdez MG Steuerwald N Malter HE Thornhill AR Cohen J
Fertil Steril, 84:343–355, 2005. - Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation development.
Wells D Bermudez MG Steuerwald N Thornhill AR Walker DL Malter H Delhanty JDA Cohen J
Hum Reprod, 20:1339–1348, 2005. - Reliability of comparative genomic hybridization to detect chromosome abnormalities in first polar bodies and metaphase II oocytes.
Gutiérrez-Mateo C Wells D Benet J Sánchez-García JF Bermúdez MG Belil I Egozcue J Munné S Navarro J
Hum Reprod, 19:2118–2125, 2004. - Advances in preimplantation genetic diagnosis.
Wells D
Eur J Obstet Gynecol Reprod Biol, 115:S97-S101, 2004. - Rabbit and pig ear skin sample cryobanking: effects of storage time and temperature of the whole ear extirpated immediately after death.
Silvestre MA Saeed AM Cervera RP Escribà MJ García-Ximénez F
Theriogenology, 59(5-6):1469-77, 2003. - Detailed investigation of factors influencing amplification efficiency and allele drop-out in single cell PCR: implications for preimplantation genetic diagnosis.
Piyamongkol W Bermudez MG Harper JC Wells D
Mol Hum Reprod, 9:411–420, 2003. - Single-cell sequencing and mini-sequencing for preimplantation genetic diagnosis.
Bermudez MG Piyamongkol W Tomaz S Dudman E Sherlock JK Wells D
Prenat Diagn, 23:669–677, 2003. - Viable offspring derived from cryopreserved haploid rabbit parthenotes
García-Ximénez F Escribà MJ
Theriogenology, 57(4):1319-25, 2002 - New techniques on embryo manipulation.
Escribà MJ Valbuena D Remohí J Pellicer A Simón C
J Reprod Immunol, 55(1-2):149-61. Review, 2002 - Vitrification and rapid freezing of rabbit fetal tissues and skin samples from rabbits and pigs.
Silvestre MA Saeed AM Escribà MJ García-Ximénez F
Theriogenology, 58 (1):69-76, 2002. - Preimplantation genetic diagnosis: an alternative to prenatal diagnosis.
Delhanty JDA Wells D
Expert Rev Mol Diagn, 2:395–399, 2002. - First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy.
Wells D Escudero T Levy B Hirschhorn K Delhanty JDA Munné S
Fertil Steril, 78:543–549, 2002. - Preimplantation genetic diagnosis for single gene disorders: experience with five single gene disorders.
Harper JC Wells D Piyamongkol W Abou-Sleiman P Apessos A Ioulianos A Davis M Doshi A Serhal P Ranieri M Rodeck C Delhanty JDA
Prenat Diagn, 22:525–533, 2002. - Towards a comprehensive analysis of chromosomes and DNA sequences in human embryos.
Wells D
In Advances in Infertility Treatment (Monduzzi Editore, Italy), p459-473. Edited by Filicori M. 2002. - The "vanishing embryo" phenomenon in an oocyte donation programme.
Rodríguez-González M Serra V García-Velasco JA Pellicer A Remohí J
Fertil Steril. 77:542-7, 2002. - Comparison of the effect of two different handling media on rabbit zygote developmental ability
Escribà MJ Silvestre MA Saeed AM García-Ximénez F
Reprod Nutr Dev, 41(2):181-6, 2001. - Acrocentric chromosome disomy is increased in spermatozoa from fathers of Turner syndrome patients
Soares SR Vidal F Bosch M Martínez-Pasarell O , Nogués C Egozcue J Templado C
Hum Genet, 108:499-503, 2001 - Numerical chromosome abnormalities in the spermatozoa of the fathers of children with trisomy 21 of paternal origin: generalised tendency to meiotic non-disjunction.
Soares SR Templado C Blanco J Egozcue J Vidal F
Hum Genet, 108:134-39, 2001. - Preimplantation genetic diagnostic protocols for alpha- and beta-thalassaemias using multiplex fluorescent PCR.
Piyamongkol W Harper JC Delhanty JDA Wells D
Prenat Diagn, 21:753–759, 2001. - PGD protocols using multiplex fluorescent PCR.
Piyamongkol W Harper CJ Delhanty JDA Wells D
Reprod Biomed Online, 2:212–214, 2001. - A successful strategy for preimplantation genetic diagnosis of myotonic dystrophy using multiplex fluorescent PCR.
Piyamongkol W Harper JC Sherlock JK Doshi A Serhal PF Delhanty JDA Wells D
Prenat Diagn, 21:223–232, 2001 - Genetic alterations in gastric cancers from British patients.
Sud R Wells D Talbot IC Delhanty JDA
Cancer Genet Cytogenet, 126:111–119, 2001. - Preimplantation genetic diagnosis: applications for molecular medicine.
Wells D Delhanty JDA
Trends Mol Med, 7:23–30, 2001 - Future developments in preimplantation genetic diagnosis.
Harper J Wells D
In Preimplantation Genetic Diagnosis (John Wiley & Sons, UK) p241-262. Edited by Harper J, Delhanty J, Handyside A. 2001. - Vitrification and rapid-freezing of cumulus cells from rabbits and pigs.
Saeed AM Escribà MJ Silvestre MA Garcia-Ximénez F
Theriogenology, 54(9):1359-71, 2000. - Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization.
Wells D Delhanty JDA
Mol Hum Reprod, 6:1055–1062, 2000. - A successful strategy for preimplantation diagnosis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency.
Ioulianos A Wells D Harper JC Delhanty JDA
Prenat Diagn, 20:593–598, 2000. - Comparative Genomic Hybridization Reveals Extensive Variation Among Different MCF-7 Cell Stocks.
Jones C Payne J Wells D Delhanty JDA Lakhani SR Kortenkamp A
Cancer Genet Cytogenet, 117:153–158, 2000. - Deletion and duplication of the adenomatous polyposis coli gene resulting from an interchromosomal insertion involving 5 (q22q23.3) in the father.
Hastings RJ Svennevik EC Setterfield B Wells D Delhanty JDA Mackinnon H
J Med Genet, 37:141–145, 2000. - Positive outcome after preimplantation diagnosis of aneuploidy in human embryos.
Munne S Magli C Cohen J Morton P Sadowy S Gianaroli L Tucker M Marquez C Sable D Ferraretti AP Massey JB Scott RT
Human Reprod, 14:2191-9, 1999. - Strategies for preimplantation genetic diagnosis of single gene disorders by DNA amplification.
Wells D Sherlock JK
Prenat Diagn, 18:1389–1401, 1998. - Preimplantation genetic diagnosis of cancer: familial adenomatous polyposis coli (FAPC).
Ao A Wells D Handyside AH Winston RML Delhanty JDA
J Assist Reprod Genet, 15:140–144, 1998. - Genetic diagnosis before implantation.
Delhanty JDA Wells D Harper JC
BMJ, 315:828–829, 1997. - Detection of haemoglobinopathies and chromosome aneuploidy from minute DNA samples using multiplex PCR.
Sherlock J Cirigliano V Petrou M Wells D Adinolfi M
In Infertility and Assisted Reproductive Technology - From Research to Therapy (Monduzzi Editore, Italy) p203-211. Edited by Ambrosini A, Melis GB, Dalla Pria S, Dessole S. 1997. - APC gene mutation and DNA microsatellite instability in pancreatic cancers of UK origin.
See CG Sud R Wells D Bowles L Ding S Habib N Delhanty JDA
GI Cancer 2, 133-137, 1996. - Preimplantation genetic diagnosis of beta-thalassaemia.
El-Hashemite N Wells D Delhanty JDA
Lancet, 348:620–621, 1996. - Rapid detection of rare variants and common polymorphisms in the APC gene by PCR-SSCP for presymptomatic diagnosis and showing allele loss.
Gayther SA Sud R Wells D Tsioupra K Delhanty JD
J Med Genet, 32:568–571, 1995. - Correlation of loss of heterozygosity with cytogenetic analysis using g-banding and fluorescence in situ hybridization in aneuploid cultures from two human testicular germ-cell tumors.
Al-Jehani RMA Wells D Fox M Parrington JM
Cancer Genet Cytogenet, 85:26–36, 1995. - Prognostic value of blastocyst grade after frozen euploid embryo transfer in patients with recurrent pregnancy loss.
Gayathree Murugappan G.Kim J Jonathan D.Kort Brent M.Hanson Shelby A.Neal W.Tiegs A K.Osman E Scott RT Lathi R B
F&S ReportsIn press, journal pre-proofAvailable online 9 July 2020 - Clinical error rates of next generation sequencing and array comparative genomic hybridization with single thawed euploid embryo transfer.
Jenna Friedenthal M.Maxwell S W.Tiegs A G. Besser A McCaffrey C Munné S Noyes N A.Grifo J
Eur J Med Genet. 2020 Jan 20:103852. doi: 10.1016/j.ejmg.2020.103852. [Epub ahead of print] - Intracytoplasmic sperm injection is not superior to conventional IVF in couples with non-male factor infertility and preimplantation genetic testing for aneuploidies (PGT-A).
De Munck N El Khatib I Abdala A El-Damen A Bayram A Arnanz A Melado L Lawrenz B Fatemi HM
Hum Reprod. 2020 Feb 29;35(2):317-327. doi: 10.1093/humrep/deaa002. - Term oocyte maturation and term ovarian stimulation: impact on oocyte competence.
Dozortsev DI Pellicer A Diamond MP
Fertil Steril. 2020 Jul 1:S0015-0282(20)30341-1. doi: 10.1016/j.fertnstert.2020.04.013. Online ahead of print. - The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers.
Reig A Franasiak J Scott RT Seli E
J Assist Reprod Genet. 2020 Mar 16. doi: 10.1007/s10815-020-01739-0. [Epub ahead of print] - Human female meiosis checkpoints: how much DNA damage is allowed?
Fragouli E Garrrido N
Fertil Steril. 2020 May;113(5):943-944. doi: 10.1016/j.fertnstert.2020.01.023. Epub 2020 Mar 20. - Mitochondrial DNA content is not predictive of reproductive competence in euploid blastocysts.
Scott RT Sun L Zhan Y Marin D Tao X Seli E
Reprod Biomed Online. 2020 May 14:S1472-6483(20)30193-0. doi: 10.1016/j.rbmo.2020.04.011. Online ahead of print. - Blastocyst mitochondrial DNA (mtDNA) is not affected by oocyte vitrification: a sibling oocyte study.
Arnanz A De Munck N Bayram A El-Damen A Abdalla A ElKhatib I Melado L Lawrenz B Fatemi HM
J Assist Reprod Genet. 2020 Jun;37(6):1387-1397. doi: 10.1007/s10815-020-01795-6. Epub 2020 May 6. - ESHRE PGT Consortium and SIG Embryology good practice recommendations for polar body and embryo biopsy for PGT.
ESHRE PGT Consortium and SIG-Embryology Biopsy Working Group Kokkali G Coticchio G Bronet F Celebi C Cimadomo D Goossens V Liss J Nunes S Sfontouris I Vermeulen N Zakharova E De Rycke M
Hum Reprod Open. 2020 May 29;2020(3):hoaa020. doi: 10.1093/hropen/hoaa020. eCollection 2020. - Interchromosomal effect in carriers of translocations and inversions assessed by preimplantation genetic testing for structural rearrangements (PGT-SR).
Mateu-Brull E Rodrigo L Peinado V Mercader A Campos-Galindo I Bronet F García-Herrero S Florensa M Milán M Rubio C
J Assist Reprod Genet. 2019 Dec;36(12):2547-2555. doi: 10.1007/s10815-019-01593-9. Epub 2019 Nov 6. - Time of morulation and trophectoderm quality are predictors of a live birth after euploid blastocyst transfer: a multicenter study.
Rienzi L Cimadomo D Delgado A Minasi MG Fabozzi G Gallego RD Stoppa M Bellver J Giancani A Esbert M Capalbo A Remohí J Greco E Ubaldi FM Messeguer M
Fertil Steril. 2019 Dec;112(6):1080-1093.e1. doi: 10.1016/j.fertnstert.2019.07.1322. - Erratum. Worth the wait? Day 7 blastocysts have lower euploidy rates but similar sustained implantation rates as Day 5 and Day 6 blastocysts.
Tiegs AW Sun L Patounakis G Scott RT
Hum Reprod. 2019 Nov 26. pii: dez219. doi: 10.1093/humrep/dez219. [Epub ahead of print] No abstract available. - Interchromosomal effect in carriers of translocations and inversions assessed by preimplantation genetic testing for structural rearrangements (PGT-SR).
Mateu-Brull E Rodrigo L Peinado V Mercader A Campos-Galindo I Bronet F García-Herrero S Florensa M Milán M Rubio C
J Assist Reprod Genet. 2019 Nov 6. doi: 10.1007/s10815-019-01593-9. [Epub ahead of print] - Reply: Careful and expert interpretation of PGT-A data can resolve the mosaicism dilemma.
Lawrenz B El-khatib I Fatemi HM
Hum Reprod. 2019 Nov 11. pii: dez176. doi: 10.1093/humrep/dez176. [Epub ahead of print] No abstract available. - Second-generation preimplantation genetic testing for aneuploidy in assisted reproduction: a SWOT analysis.
Bellver J Bosch E Espinós J García-Velasco JA Fabregues F Fontes J Llácer J Requena A Checa MA
Reprod Biomed Online. 2019 Aug 13. pii: S1472-6483(19)30695-9. doi: 10.1016/j.rbmo.2019.07.037. [Epub ahead of print] Review. - Clinical outcomes after the transfer of blastocysts characterized as mosaic by high resolution Next Generation Sequencing- further insights.
Munné S Spinella F Grifo J Zhang J Beltran MP Fragouli E Fiorentino F
Eur J Med Genet. 2019 Aug 21:103741. doi: 10.1016/j.ejmg.2019.103741. [Epub ahead of print] - Worth the wait? Day 7 blastocysts have lower euploidy rates but similar sustained implantation rates as Day 5 and Day 6 blastocysts.
Tiegs AW Sun L Patounakis G Scott RT
Hum Reprod. 2019 Aug 12. pii: dez138. doi: 10.1093/humrep/dez138. [Epub ahead of print] - mtDNA dynamics between cleavage-stage embryos and blastocysts.
De Munck N Liñan A Elkhatib l Bayram A Arnanz A Rubio C Garrido N Lawrenz B Fatemi HM
J Assist Reprod Genet. 2019 Aug 7. doi: 10.1007/s10815-019-01544-4. [Epub ahead of print] - Preimplantation genetic screening for aneuploidy (PGT-A 2.0) in assisted reproduction: A SWOT analysis
J. Bellver E-Bosch JJ Espinós F.Fabregues J. Fontes J. García-Velasco J. Llácer A. Requena MA Checa
Reproductive BioMedicine Online, In press, journal pre-proof, Available online 16 May 2019 - PGDIS Position Statement on the Transfer of Mosaic Embryos 2019.
Cram DS Leigh D Handyside A Rechitsky L Harton G Grifo J Rubio C Fragouli E Kahraman S Katz-Jaffe M Tempest H Thornhill A Strom C Escudero T Qiao J Munne S Simpson JL Kuliev A
Reprod Biomed Online. 2019 Aug;39 Suppl 1:e1-e4. doi: 10.1016/j.rbmo.2019.06.012. No abstract available. - When next-generation sequencing-based preimplantation genetic testing for aneuploidy (PGT-A) yields an inconclusive report: diagnostic results and clinical outcomes after re biopsy.
Neal SA Sun L Jalas C Morin SJ Molinaro T Scott RT
J Assist Reprod Genet. 2019 Aug 30. doi: 10.1007/s10815-019-01550-6. [Epub ahead of print] - Segmental aneuploidy in human blastocysts: a qualitative and quantitative overview.
Escribà MJ Vendrell X Peinado V
Reprod Biol Endocrinol. 2019 Sep 16;17(1):76. doi: 10.1186/s12958-019-0515-6. - Ovarian Stimulation (OS) Does Not Influence the Uterine Immune Environment in Healthy Infertile Women
D. Alecsandru A. Pacheco A. Guerrero-Mayo A. Fabris P. Aparicio A. Barrio Pellicer A Juan A García-Velasco
Reproductive BioMedicine Online, In press, journal pre-proof, Available online 22 August 2019 - Embryonic aneuploidy rates are equivalent in natural cycles and gonadotropin-stimulated cycles.
Hong KH Franasiak JM Patounakis G Juneau CR Scott RT
Fertil Steril. 2019 Oct;112(4):670-676. doi: 10.1016/j.fertnstert.2019.05.039. - Divining the genetic status of embryos: consult the medium?
Dhruti Babariya D.Phil Megan Leaver M Dagan Wells
Fertility and Sterility, In press, corrected proof,Available online 29 July 2019 - Cleavage stage mitochondrial DNA is correlated with preimplantation human embryo development and ploidy status.
Bayram A De Munck N Elkhatib I Arnanz A Liñán A Lawrenz B Fatemi HM
J Assist Reprod Genet. 2019 Jul 10. doi: 10.1007/s10815-019-01520-y. [Epub ahead of print] - Embryonic Aneuploidy after Preimplantation Genetic Screening: Age- and Indication-Matched Comparative Study between Indian and Spanish Population.
Kotdawala A Mir P Herrero J Khajuria R Lalitkumar PGL Banker MR
J Hum Reprod Sci. 2019 Apr-Jun;12(2):141-149. doi: 10.4103/jhrs.JHRS_109_18. - Transcriptomic behavior of genes associated with chromosome 21 aneuploidies in early embryo development.
Sanchez-Ribas I Diaz-Gimeno P Sebastián-León P Mercader A Quiñonero A Ballesteros A Pellicer A Domínguez F
Fertil Steril. 2019 May;111(5):991-1001.e2. doi: 10.1016/j.fertnstert.2019.01.023. Epub 2019 Mar 25 - The clinicians´ dilemma with mosaicism-an insight from inner cell mass biopsies.
Lawrenz B El Khatib I Liñán A Bayram A Arnanz A Chopra R De Munck N Fatemi HM
Hum Reprod. 2019 May 22. pii: dez055. doi: 10.1093/humrep/dez055. [Epub ahead of print] - The preimplantation genetic testing debate continues: first the hype, then the tension, now the hypertension?
Patounakis G Hill MJ
Fertil Steril. 2019 May 27. pii: S0015-0282(19)30407-8. doi: 10.1016/j.fertnstert.2019.04.028. [Epub ahead of print] No abstract available. - Gene Editing Should Replace Embryo Selection Following PGD.
Wells D Vermeesch JR Simpson JL
Prenat Diagn. 2019 Mar 4. doi: 10.1002/pd.5442. [Epub ahead of print] No abstract available. - Mitochondria as a Biomarker for IVF Outcome.
Kim J Seli E
Reproduction. 2019 Mar 1. pii: REP-18-0580.R2. doi: 10.1530/REP-18-0580. [Epub ahead of print] Review. - Mitochondrial DNA copy number as a predictor of embryo viability.
Cecchino GN Garcia-Velasco JA
Fertil Steril. 2019 Feb;111(2):205-211. doi: 10.1016/j.fertnstert.2018.11.021. Epub 2019 Jan 2. Review. - Mosaic embryos present a challenging clinical decision.
Osman EK Werner MD
Fertil Steril. 2019 Jan;111(1):52-53. doi: 10.1016/j.fertnstert.2018.10.032. No abstract available. - The cytogenetic constitution of human blastocysts: insights from comprehensive chromosome screening strategies.
Fragouli E Munne S Wells D
Hum Reprod Update. 2019 Jan 1;25(1):15-33. doi: 10.1093/humupd/dmy036. - The model of "genetic compartments": a new insight into reproductive genetics.
Vendrell X Escribà MJ
J Assist Reprod Genet, NA:NA-NA, 2018. - Preimplantation genetic testing for aneuploidy is cost-effective, shortens treatment time, and reduces the risk of failed embryo transfer and clinical miscarriage.
Neal SA Morin SJ Franasiak JM Goodman L Juneau CR Forman EJ Werner MD Scott RT
Fertil Steril, 110(5):896-904, 2018. - Quest for a less invasive approach to preimplantation genetic testing remains ongoing
Neal SA Werner MD
Fertil Steril, 110(5):854-856, 2018. - Minimizing mosaicism: assessing the impact of fertilization method on rate of mosaicism after next-generation sequencing (NGS) preimplantation genetic testing for aneuploidy (PGT-A).
Palmerola KL Vitez SF Amrane S Fischer CP Forman EJ
J Assist Reprod Genet, NA:NA-NA, 2018. - The model of "genetic compartments": a new insight into reproductive genetics.
Vendrell X Escribà MJ
J Assist Reprod Genet, doi: 10.1007/s10815-018-1366-3.2018 - The Status of Genetic Screening in Recurrent Pregnancy Loss.
Kaser DJ
Obstet Gynecol Clin North Am, 45(1):143-154, 2018. - What to do when good-quality embryos repeatedly fail to implant.
Coughlan C
Best Pract Res Clin Obstet Gynaecol, 53:48-59, 2018. - Pregnancy after vasectomy: surgical reversal or assisted reproduction?
Valerie U De Brucker S De Brucker M Vloeberghs V Drakopoulos P Santos-Ribeiro S Tournaye H
Tournaye H.Hum Reprod, 1;33(7):1218-27, 2018. - Does the type of GnRH analogue used, affect live birth rates in women with endometriosis undergoing IVF/ICSI treatment, according to the rAFS stage?
Drakopoulos P Rosetti J Pluchino N Blockeel C Santos-Ribeiro S de Brucker M Drakakis P Camus M Tournaye H Polyzos NP
Gynecol Endocrinol, 12:1-6, 2018. - Premature progesterone elevation: targets and rescue strategies.
Lawrenz B Labarta E Fatemi HM Bosch E
Fertil Steril, 109(4):577-582, 2018. - The impact of contemporary preimplantation genetic screening and diagnosis on the detection of aneuploidy and inherited genetic diseases.
Neal SA Werner MD
Birth Defects Res, 110(8):644-647, 2018. - Next generation sequencing for preimplantation genetic testing for aneuploidy: friend or foe?
Fragouli E
Fertil Steril, 109(4):606-607, 2018. - Very low anti-müllerian hormone concentrations are not an independent predictor of embryo quality and pregnancy rate.
Pacheco A Cruz M Iglesias C García-Velasco JA
Reprod Biomed Online, 37(1):113-119, 2018. - Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos.
Wang T Babayev E, Jiang Z Li G Zhang M Esencan E Horvath T Seli E
Aging Cell, 30:e12784. doi: 10.1111/acel.12784, 2018. - Veratridine-sensitive Na+ channels regulate human sperm fertilization capacity.
Candenas L Pinto FM Cejudo Román A González-Ravina C Fernández-Sánchez M Pérez-Hernández Irazusta J Subirán N
Life Sci, 196:48-55, 2018. - Cumulus cell transcriptome profiling is not predictive of live birth after in vitro fertilization: a paired analysis of euploid sibling blastocysts.
Green KA Franasiak JM Werner MD Tao X Landis JN Scott RT Treff NR
Fertil Steril, 109(3):460-466, 2018. - The Status of Genetic Screening in Recurrent Pregnancy Loss.
Kaser DJ
Obstet Gynecol Clin North Am, 45(1):143-154. doi: 10.1016/j.ogc.2017.10.007, 2018. - Validation of a targeted next generation sequencing-based comprehensive chromosomescreening platform for detection of triploidy in human blastocysts.
Marin D Zimmerman R Tao X Zhan Y Scott RT Treff NR
Reprod Biomed Online, 36(4):388-395, 2018. - Risk of pelvic inflammatory disease after intrauterine insemination: a systematic review.
Matorras R Rubio K Iglesias M Vara I Expósito A.
Hum Reprod, 36(2):164-171. doi: 10.1016/j.rbmo.2017.11.002, 2018, - Unexpected repeat immature oocyte response after IVF stimulation: a case report.
Mishra V Chirumamilla L
Gynecol Endocrinol, 34(2):100-102. doi: 10.1080/09513590.2017.1369514, 2018. - The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology.
Moreno I Cicinelli E Garcia-Grau I Gonzalez M Bau D Vilella F Ziegler D Resta L Valbuena D Simón C
Am J Obstet Gynecol, 218(6):602-602, 2018. - Three-Dimensional Angiogenic Evaluation of the Effect of Mifepristone in early gestation: pilot study
Pellicer-Iborra B Herraiz S Morales A Martínez S Garrido N Pellicer A
Gynecol Obstet, 7:90932,1000451, 2018. - NGS Analysis of Human Embryo Culture Media Reveals miRNAs of Extra Embryonic Origin.
Sanchez-Ribas I Díaz-Gimeno P Quiñonero A Ojeda M Larreategui Z Ballesteros A Domínguez F
Reprod Sci, NA:NA-NA, 2018. - Origin and composition of cell-free DNA in spent medium from human embryo culture during preimplantation development.
Vera-Rodriguez M Diez-Juan A Jimenez-Almazan J Martínez S Navarro R Peinado V Mercader A Meseguer M Blesa D Moreno I Valbuena D Rubio C Simón C
Hum Reprod, 33(4):745-756, 2018. - Validation of a targeted next generation sequencing-based comprehensive chromosomescreening platform for detection of triploidy in human blastocysts.
Marin D Zimmerman R Tao X Zhan Y Scott RT Treff NR
Reprod Biomed Online, pii: S1472-6483(17)30710-1. doi: 10.1016/j.rbmo.2017.12.015, 2018. - Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the IVF population
Juneau C Kraus E Werner MD Franasiak JM Morin SJ Patounakis G Molinaro T de Ziegler D Scott RT
Fertil Steril, 108: 284-288, 2017. - Detection of mosaicism at blastocyst stage with the use of high-resolution next-generation sequencing.
Munné S Wells D
Fertil Steril, 107:1085–1091, 2017. - Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the in vitro fertilization population.
Juneau C Kraus E Werner MD Franasiak JM Morin SJ Patounakis G Molinaro T De Ziegler D Scott RT
Fertil Steril, 108(2):284-288, 2017. - Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.
Zhang J Liu H Luo S Lu Z Chávez-Badiola A Liu Z Yang M Merhi Z Silber SJ Munné S Konstandinidis M Wells D Huang T
Reprod Biomed Online, 34:361-368, 2017. - Detailed investigation into the cytogenetic constitution and pregnancy outcome of replacing mosaic blastocysts detected with the use of high-resolution next-generation sequencing.
Munné S Blazek J Large M Martinez-Ortiz PA Nisson H Liu E Tarozzi N Borini A Becker A Zhang J Maxwell S Grifo J Babariya D Wells D Fragouli E
Fertil Steril, 108:62-71, 2017. - Karyomapping: a single centre experience from application of methodology to ongoing pregnancy and live-birth rates.
Ben-Nagi J Wells D Doye K Exeter H Drew E Alfarawati S Naja R Serhal P Loutradi K
Reprod Biomed Online, 35:264–271, 2017. - Mitochondrial DNA Quantification- the devil in the detail
Wells D Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munné S Fragouli E
Hum Reprod, 32:2150–2151, 2017. - Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts.
Fragouli E Alfarawati S Spath K Babariya D Tarozzi N Borini A Wells D
Hum Genet, 136: 805-819, 2017 - Type of chromosome abnormality affects embryo morphology dynamics.
Del Carmen Nogales M Bronet F Basile N Martínez EM Liñán A Rodrigo L Meseguer M
Fertil Steril, 107(1):229-235, 2017. - In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study.
Rubio C Bellver J Rodrigo L Castillón G Guillén A Vidal C Giles J Ferrando M Cabanillas S Remohí J Pellicer A Simón C
Fertil Steril. 2017 May;107(5):1122-1129. doi: 10.1016/j.fertnstert.2017.03.011. Epub 2017 Apr 19. - High relative deoxyribonucleic acid content of trophectoderm biopsy adversely affects pregnancy outcomes.
Neal SA Franasiak JM Forman EJ Werner MD Morin SJ Tao X Treff NR Scott RT
Fertil Steril, 107(3):731-736, 2017. - Crossing the germline: CRISPR-Cas9 and our responsibility as reproductive endocrinology and infertility physicians.
Kaser DJ Franasiak JM
J Assist Reprod Genet. 2018 Mar;35(3):399-402. doi: 10.1007/s10815-017-1075-3. Epub 2017 Oct 30. - Reply: Detecting mosaicism in trophectoderm biopsies.
Capalbo A Ubaldi F Rienzi L Scott RT Treff N
Hum Reprod. 2017 Mar 1;32(3):714-715. doi: 10.1093/humrep/dew347. No abstract available. - Abnormally fertilized oocytes can result in healthy live births: improved genetic technologies for preimplantation genetic testing can be used to rescue viable embryos in in vitro fertilization cycles
Capalbo A Treff N Cimadomo D Tao X Ferrero S Vaiarelli A Colamaria S Maggiulli R Orlando G Scarica C Scott RT Ubaldi FM Rienzi L
Fertil Steril. 2017 Sep 15. pii: S0015-0282(17)31699-0. doi: 10.1016/j.fertnstert.2017.08.004. [Epub ahead of print - Genomic instability during reprogramming by nuclear transfer is DNA replication dependent.
Chia G Agudo J Treff N Sauer MV Billing D Brown BD Baer R Egli D
Nat Cell Biol. 2017 Apr;19(4):282-291. doi: 10.1038/ncb3485. Epub 2017 Mar 6. - Spermatozoa with numerical chromosomal abnormalities are more prone to be retained by Annexin V-MACS columns.
Esbert M Godo A Soares SR Florensa M Amorós D Ballesteros A Vidal F
Andrology. 2017 Jun 14. doi: 10.1111/andr.12376. [Epub ahead of print] - Evaluation of comprehensive chromosome screening platforms for the detection of mosaic segmental aneuploidy.
Goodrich D Xing T Tao X Lonczak A Zhan Y Landis J Zimmerman R Scott RT Treff NR
J Assist Reprod Genet. 2017 Jun 2. doi: 10.1007/s10815-017-0924-4. [Epub ahead of print] - Continuing to deliver: the evidence base for pre-implantation genetic screening.
Griffin DK Fishel S Gordon T Yaron Y Grifo J Hourvitz A Rechitsky S Elson J Blazek J Fiorentino F Treff N Munne S Leong M Schmutzler A Vereczkey A Ghobara T Nánássy L Large M Hamamah S Anderson R Gianaroli L Wells D
BMJ. 2017 Feb 14;356:j752. doi: 10.1136/bmj.j752. No abstract available - Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the in vitro fertilization population.
Juneau C Kraus E Werner MD Franasiak JM Morin SJ Patounakis G Molinaro T De Ziegler D Scott RT
Fertil Steril. 2017 Jun 23. pii: S0015-0282(17)30421-1. doi: 10.1016/j.fertnstert.2017.05.038. [Epub ahead of print] - A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of EuploidEmbryos.
Labarta E Bosch E Mercader A Alamá P Mateu E Pellicer A
Biomed Res Int. Received 13 November 2016; Accepted 23 February 2017; Published 27 March 2017 - Corrigendum to "A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of Euploid Embryos".
Labarta E Bosch E Mercader A Alama P Mateu E Pellicer A
Biomed Res Int. 2017;2017:1718068. doi: 10.1155/2017/1718068. Epub 2017 Jul 13. - Comprehensive chromosome screening and gene expression analysis from the same biopsy in human preimplantation embryos.
Marin D Wang Y Tao X Scott RT Treff NR
Mol Hum Reprod. 2017 May 1;23(5):330-338. doi: 10.1093/molehr/gax014 - Preimplantation embryonic mosaicism: origin, consequences and the reliability of comprehensive chromosome screening.
Marin D Scott RT Treff NR
Curr Opin Obstet Gynecol. 2017 Jun;29(3):168-174. doi: 10.1097/GCO.0000000000000358. - Identification and characterization of Aurora Kinase B and C variants associated with maternal aneuploidy.
Nguyen AL Marin D Zhou A Gentilello AS Smoak EM Cao Z Fedick A Wang Y Taylor D Scott RT Xing J Treff N Schindler K
Mol Hum Reprod. 2017 Mar 25. doi: 10.1093/molehr/gax018. [Epub ahead of print] - In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study.
Rubio C Bellver J Rodrigo L Castillón G Guillén A Vidal C Giles J Ferrando M Cabanillas S Remohí J Pellicer A Simón C
Fertil Steril. 2017 May;107(5):1122-1129. doi: 10.1016/j.fertnstert.2017.03.011. Epub 2017 Apr 19. - Introduction: Subchromosomal abnormalities in preimplantation embryonic aneuploidy screening.
Scott RT
Fertil Steril. 2017 Jan;107(1):4-5. doi: 10.1016/j.fertnstert.2016.11.017 - Advances in Preimplantation Genetic Testing for Monogenic Disease and Aneuploidy.
Treff NR Zimmerman RS.
Annu Rev Genomics Hum Genet. 2017 May 12. doi: 10.1146/annurev-genom-091416-035508. [Epub ahead of print] - Assessment of embryo morphology and developmental dynamics by time-lapse microscopy: is there a relation to implantation and ploidy?
Zaninovic N Irani M Meseguer M
Fertil Steril. 2017 Nov;108(5):722-729. doi: 10.1016/j.fertnstert.2017.10.002. Review. - Detection of segmental aneuploidy and mosaicism in the human preimplantation embryo: technical considerations and limitations.
Treff N Franasiak JM
Fertil Steril, 107:27-31 - Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe. J Glob Oncol. 4, pp. 1 - 16. 28/06/2017.
Rashedi AS de Roo SF Ataman LM Edmonds ME Silva AA Scarella A Horbaczewska A Anazodo A Arvas A Ramalho de Carvalho B Sartorio C Beerendonk CCM Diaz-Garcia C
- Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy.
Ravichandran K Guzman L Escudero T Zheng X Colls P Jordan A Cohen J Wells D Munné S
Reprod Biomed Online, 33:550–559, 2016. - The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.
Sermon K Capalbo A Cohen J Coonen E De Rycke M De Vos A Delhanty J Fiorentino F Gleicher N Griesinger G Grifo J Handyside A Harper J Kokkali G Mastenbroek S Meldrum D Meseguer M Montag M Munné S Rienzi L Rubio C Scott KScott RT Simón C Swain J Treff N Ubaldi F Vassena R Vermeesch J Verpoest W Wells D Geraedts J
Mol Hum Reprod, 22:845–857, 2016. - Why do euploid embryos miscarry? A case-control study comparing the rate of aneuploidy within presumed euploid embryos that resulted in miscarriage or live birth using next-generation sequencing.
Maxwell SM Colls P Hodes-Wertz B McCulloh DH McCaffrey C Wells D Munné S Grifo J
Fertil Steril, 106:1414-1419, 2016. - Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.
Enciso M Sarasa J Xanthopoulou L Bristow S Bowles M Fragouli E Delhanty J Wells D
Hum Genet, 135:555–568, 2016. - Preimplantation genetic diagnosis: an overview and recent advances.
Ben-Nagi J Serhal P SenGupta S Doye K Wells D
Obstet Gynaecol, 18:99–106, 2016. - Current controversies in prenatal diagnosis 4: preimplantation genetic screening should be routinely offered to all preimplantation genetic diagnosis cases.
Harper J Wells D Simpson JL
Prenat Diagn, 36:25–28, 2016. - Mosaicism: “survival of the fittest” versus “no embryo left behind”.
Munné S Grifo J Wells D
Fertil Steril, 105:1146–1149, 2016. - Preimplantation genetic diagnosis for infertility.
Wells D Lewin J
In Textbook of Assisted Reproductive technologies, 5th Edition (Informa Healthcare, UK), p346-353. Edited by Gardner D, Weissman A, Howles C, Shoham Z. 2016. - Embryonic aneuploidy does not differ among genetic ancestry according to continental origin as determined by ancestry informative markers.
Franasiak JM Olcha M Shastri S Molinaro T Congdon H Treff NR Scott RT
HumReprod, 31(10):2391-5, 2016 - Kinetics of the early development of uniparental human haploid embryos.
Escribà MJ Escrich L Galiana Y Grau N Galán A Pellicer A
Fertil Steril, 105(5):1360-1368, 2016. - Aneuploidy screening by array comparative genomic hybridization improves success rates of in vitro fertilization: A multicenter Indian study.
Kotdawala A Patel D Herrero J Khajuria R Mahajan N Banker M
J Hum Reprod Sci, 9(4):223-229, 2016. - The challenge of embryonic mosaicism in preimplantation genetic screening.
Scott RT Galliano D
Fertil Steril; 105 (5): 1150-1152, 2016 - Técnicas invasivas y no invasivas en el diagnóstico de embriones humanos.
Calomarde C Carmona L Guerra I Gutiérrez D Santana A Domingo J
Rev Iberoam Fert Rep Hum, 33: 67-72, 2016. - Automatic time-lapse instrument is superior to single-point morphology observation for selecting viable embryos: retrospective study in oocyte donation.
Aparicio-Ruiz B Basile N Basile N Pérez Albalá S Bronet F Remohí J Meseguer M
Fertil Steril, 106:1379-85, 2016. - Embryonic aneuploidy does not differ amongst major ethnicities as determined by genotyping.
Franasiak JM Olcha M Treff N Scott RT
Hum Reprod 31:2391-5, 2016. - Challenges facing contemporary preimplantation genetic screening.
Juneau C Franasiak JM Treff N
Curr Opin Obstet Gynecol 28:151-7, 2016. - Preimplantation genetic screening - what a wonderful world it would be!
García-Velasco JA Fauser BC
Reprod Biomed Online. 32:337-8. 2016. - Pathophysiologic processes have an impact ot the plasma metabolomics signature of endometriosis patients.
Vicente-Muñoz S Morcillo I Puchades-Carrasco L Payá V Pellicer A Pineda-Lucena A
Fertil Steril, 106 (7): 1733-1741. E1, 2016. - A randomized and blinded comparison of qpcr and NGS based detection of aneuploidy in a cell line mixture model of blastocyst biopsy mosaicism.
Goodrich D Tao X Bohrer C Lonczak A Xing T Zimmerman R Zhan Y Scott RT Treff NR
Human Reprod, 30(2);276-83, 2015. - SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts.
Treff NR Thompson K Rafizadeh M Chow M Morrison L Tao X Garnsey H Reda CV Metzgar TL Neal S Jalas C Scott RT Forman E
J Assist Reprod Genet, 33:1115-9, 2016. - Next Generation Sequencing Based Comprehensive Chromosome Screening in Mouse Polar Bodies, Oocytes, and Embryos.
Treff NR Krisher R Tao X Garnsey H Bohrer C Silva E Landis J Taylor D Scott RT Woodruff TK Duncan FE
Biol Reprod, 94:76, 2016. - Development and validation of concurrent preimplantation genetic diagnosis for single gene disorders and comprehensive chromosomal aneuploidy screening without whole-genome amplification.
Zimmerman RS Jalas C Tao X Fedick AM Kim J Pepe RJ Northrop LE Scott RT Treff NR
Fertil Steril, 105:286-94, 2016. - 24-chromosome PCR for aneuploidy screening.
Werner MD Scott RT
Curr Opin Obstet Gynecol. 2015. - Karyomapping allows preimplantation genetic diagnosis of a de-novo deletion undetectable using conventional PGD technology.
Giménez C Sarasa J Arjona C Vilamajó E Martínez-Pasarell O Wheeler K Valls G Garcia-Guixé E Wells D
Reprod Biomed Online, 31:770–775, 2015. - Live births following Karyomapping of human blastocysts: experience from clinical application of the method.
Konstantinidis M Prates R Goodall N Fischer J Tecson V Lemma T Chua B Jordan A Armenti E Wells D Munné S
Reprod Biomed Online, 31:394–403, 2015. - Deep impact: sequencing embryo biopsy specimens at increasing depth.
Spath K Wells D
Reprod Biomed Online, 31:1–3, 2015. - Karyomapping - a comprehensive means of simultaneous monogenic and cytogenetic PGD: comparison with standard approaches in real time for Marfan syndrome.
Thornhill AR Handyside AH Ottolini C Natesan SA Taylor J Sage K Harton G Cliffe K Affara N Konstantinidis M Wells D Griffin DK
J Assist Reprod Genet, 32:347–356, 2015. - Routine use of next-generation sequencing for preimplantation genetic diagnosis of blastomeres obtained from embryos on day 3 in fresh in~vitro fertilization cycles.
?ukaszuk K Pukszta S Wells D Cybulska C Liss J P?óciennik ? Kuczy?ski W Zabielska J
Fertil Steril, 103:1031–1036, 2015. - Comprehensive carrier genetic test using next-generation deoxyribonucleic acid sequencing in infertile couples wishing to conceive through assisted reproductive technology
Martin J Asan Y Alberola T Rodríguez-Iglesias B Jiménez-Almazán J Li Q Du H Alama P Ruiz A Bosch E Garrido N Simón C
Fertil Steril, 104(5):1286-93, 2015. - The use of morphokinetics as a predictor of implantation: a multicentric study to define and validate an algorithm for embryo selection.
Basile N Vime P Florensa M Aparicio-Ruiz B García-Velasco JA Remohí J Meseguer M
Hum Reprod, 30(2):276-83, 2015. - Systematic review on clinical outcomes following selection of human preimplantation embryos with time-lapse monitoring.
Freour T Basile N Barriere P Meseguer M
Hum Reprod Update, 21(1):153-4, 2015 - Endometrial Microbiome at the Time of Embryo Transfer: Next Generation Sequencing of the 16s Ribosomal Subunit.
Franasiak JM Werner MD Juneau C Tao X Landis J Zhan Y Treff N Scott RT
J Assist Reprod Genet 33:129-36, 2015. - Discordant embryonic aneuploidy testing and prenatal ultrasonography prompting androgen insensitivity syndrome diagnosis.
Franasiak JM Yao X Ashkindaze E Rosen T Scott RT
Obstet Gynecol 125:383-6, 2015. - Comprehensive chromosome screening improves embryo selection: a meta-analysis.
Dahdouh EM Balayla J García-Velasco JA
Fertil Steril. 104:1503-12, 2015. - Preimplantation genetic screening using comprehensive chromosome screening: evidence and remaining challenges.
Dahdouh EM Balayla J García-Velasco JA
Hum Reprod. 30:1515-6, 2015. - The time to prevent mendelian genetic diseases from donated or own gametes has come.
Garrido N Bosch E Alamá P Ruiz A
Fertil Steril, 104:833-835, 2015. - Diagnosis of human preimplantation embryo viability
Gardner D Meseguer M Rubio C Treff N
Hum Reprod Update, 21:727-747, 2015. - The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening.
Franasiak JM Forman EJ Hong KH Werner MD Upham KM Treff NR
Fertil Steril 2014;101(3):656–663.e1. - Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform.
Konstantinidis M Alfarawati S Hurd D Paolucci M Shovelton J Fragouli E Wells D
Fertil Steril, 102:1385–1392, 2014. - Live birth after PGD with confirmation by a comprehensive approach (karyomapping) for simultaneous detection of monogenic and chromosomal disorders.
Natesan SA Handyside AH Thornhill AR Ottolini CS Sage K Summers MC Konstantinidis M Wells D Griffin DK
Reprod Biomed Online, 29:600–605, 2014. - Human embryonic aneuploidy.
Fragouli E Wells D
Encyclopedia of Life Sciences, Online, 2014. - Clinical utilization of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation.
Wells D Kaur K Grifo J Glassner M Taylor JC Fragouli E Munné S
J Med Genet, 51:553–562, 2014. - Telomere length and aneuploidy: clinical and biological insights into human preimplantation embryos.
Simpson JL Wells D
Reprod Biomed Online, 28:531–532, 2014. - Next-generation sequencing: the dawn of a new era for preimplantation genetic diagnostics.
Wells D
Fertil Steril, 101:1250–1251, 2014. - Role of statins in PCOS management
Ortega I Duleba AJ
Chapter 11, pp 181-203. Editor: Lubna Pal. Springer, 2014. - Live birth after embryo transfer in an unresponsive thin endometrium.
Cruz F Bellver J
Gynecol Endocrinol. 2014 Jul;30(7):481-4. - Embryo aneuploidy screening with CGH arrays in the absence of implantation.
García-Herrero S García-Herrero S Rodrigo L Mateu E Peinado V Milán M Campos-Galindo I Vera M Mercader A Bronet F Requena A Simón C Rubio C
Médecine de la Reproduction, Gynécologie Endocrinologie, 16:112-119, 2014. - Increasing the probability of selecting chromosomally normal embryos by time-lapse morphokinetics analysis.
Basile N Nogales MC Bronet F Florensa M Riqueiros M Rodrigo L García-Velasco JA Meseguer M
Fertil Steril, 101:699-704, 2014. - Increasing the probability of selecting chromosomally normal embryos by time-lapse morphokinetic analysis.
Basile N Bronet F Nogales MC Martínez E Ariza M Agudo Garcillán D Florensa M Riqueros M Meseguer M
Fertil Steril 101(3):699-704, 2014. - Embryonic aneuploidy: overcoming molecular genetics challenges improves outcomes and changes practice patterns.
Franasiak JM Scott RT
Trends Mol Med 20:499-508, 2014. - Clinical genetic testing for male factor infertility: current applications and future directions.
Hotaling J Carrell DT
Andrology, 2(3), 339-50, 2014 - Embryo biopsy for aneuploidy detection in the general infertility population.
Kaser DJ Ginsburg ES
Seminars of Reproductive Medicine, vol 31, 2014. Ed. V Baker. New York, NY: Thieme Medical Publishers. - Comparison of array comparative genomic hybridization and quantitative real-time PCR-based aneuploidy screening of blastocyst biopsies.
Capalbo A Treff N Cimadomo D Tao X Upham K Ubaldi F Rienzi L Scott RT
Eur J Hum Genet, 23:901-6, 2014 - Polar body based aneuploidy screening is poorly predictive of embryo ploidy and reproductive potential.
Salvaggio C Forman E Garnsey H Treff N Scott RT Gueye I
J Assist Reprod Genet, 31:1221-6, 2014. - Improved sensitivity to detect recombination using qPCR for Dyskeratosis Congenita PGD.
Gueye N Jalas C Tao X Taylor D Scott RT Treff NR
JARG, 31:1227-30, 2014 - Obstetrical and neonatal outcomes from the BEST Trial: Single embryo transfer with aneuploidy screening improves outcomes after in vitro fertilization without compromising delivery rates.
Forman EJ Hong KH Franasiak JM Scott RT
Am J Obstet Gynecol, 210:157, 2014. - Uniparental disomy in the human blastocyst is exceedingly rare.
Gueye N Devkota B Taylor D Pfundt R Scott RT Tref N
Fertil Steril, 101: 232 -236, 2014. - The ethical implications of preimplantation genetic diagnosis.
Gronowski AM Scott RT Caplan AL Nelson LJ
Clin Chem, 60:25-8, 2014. - To preserve or not to preserve: How difficult is the decision about fertility preservation?
Mersereau JE Goodman L Deal AM Gorman JR Whitcomb BW Su HI
Cancer. 2013 Nov 15;119(22):4044-50. - Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis.
Sokalska A Anderson M Villanueva JA Ortega I Bruner-Tran KL Osteen KV Duleba AJ
J Clin Endocrinol Metabol, 2013. - Treatment of Luteal Phase Defects in Assisted Reproduction.
Muñoz E Taboas E Portela S Aguilar J Fernandez I Muñoz L Bosch E
Curr Drug Targets. Jul; 14(8):832-42, 2013. - Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials.
Rubio C Bellver J Rodrigo L Bosch E Mercader A Vidal C De Los Santos MJ Giles J
Fertil Steril, 99(5):1400-7, 2013 - Metabolomic profiling of oocytes and embryos using spectroscopy: potential clinical use and pitfalls.
Sakkas D Seli E
In: D. Gardner, D. Sakkas, E. Seli, D. Wells eds. Emerging technologies for the assessment and diagnosis of gametes and embryos. Springer/Humana Press, Berlin, Germany, pp 275-280, 2013. - The origin and impact of embryonic aneuploidy.
Fragouli E Alfarawati S Spath K Jaroudi S Sarasa J Enciso M Wells D
Hum Genet, 132:1001–1013, 2013. - Questions about the accuracy of polar body analysis for preimplantation genetic screening.
Fragouli E Wells D
Hum Reprod, 28:1731–1732, 2013. - High-density SNP arrays and next generation sequencing for pre-implantation genetic diagnosis.
Handyside A Wells D
In Gamete and embryo assessment in assisted reproduction: emerging technologies (Springer Scientific), p135-146. Edited by Gardner, D., Sakkas, D., Seli, E. and Wells, D. 2013. - Alterations in the gene expression of aneuploid oocytes and associated cumulus cells.
Wells D
Biology and Pathology of the Oocyte, Role in Fertility and Reproductive Medicine (Cambridge University Press), p346-352. Edited by Eichenlaub-Ritter U, Gosden R, Trounson A. 2013. - Preimplantation genetic screening.
Wells D
The Textbook of Clinical Embryology (Cambridge University Press, UK). p357-363. Edited by Coward K. and Wells D. 2013. - Preimplantation genetic diagnosis.
Wells D Fragouli E
The Textbook of Clinical Embryology (Cambridge University Press, UK). p346-356. Edited by Coward K. and Wells D. 2013. - Obstetric and neonatal outcomes from the BEST Trial: Single embryo transfer with aneuploidy screening improves outcomes after IVF without compromising delivery rates.
Forman EJ Hong KH Franasiak JM Scott RT
Am J Obstet Gynecol, 210:157.e1-6, 2013. - Additive effect of factors related to assisted conception on the reduction of maternal serum pregnancy-associated plasma protein A concentrations and the increased false-positive rates in first-trimes
Bellver J Casanova C Garrido N Lara C Remohí J Pellicer A Serra V
Fertil Steril, 100:1314-1320.e3, 2013. - False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3.
Mir P Rodrigo L Mercader A Buendía P Mateu E Milán-Sánchez M Peinado V Pellicer A Remohí J Simón C Rubio C
J Assist Reprod Genet, 30 (1); 143-9, 2013. - Selecting the optimal time to perform biopsy for preimplantation genetics
Scott KL Hong KH Scott RT
Fertil Steril, 100: 608-614, 2013. - Incidental identification of balanced translocation carrier patients through comprehensive chromosome screening of IVF-derived blastocysts.
Treff NR Forman EJ Katz-Jaffe MG Schoolcraft WB Levy B Scott RT
J Assist Reprod Genet, 30:787-91, 2013. - Next-generation sequencing for preimplantation genetic diagnosis. Letter to the Editor.
Treff NR Forman EJ Scott RT
Fertil Steril, 99:e17-18, 2013 - Evaluation of targeted next-generation sequencing based preimplantation genetic diagnosis of monogenic disease.
Treff NR Fedick A Tao X Devkota B Taylor D Scott RT
Fertil Steril, 99:1377-1384, 2013. - Four-hour quantitative real-time polymerase chain reaction– based comprehensive chromosome screening and accumulating evidence of accuracy, safety predictive values and clinical efficacy.
Treff NR Scott RT
Fertil Steril, 99: 1049-1053, 2013. - Embryos whose polar bodies contain isolated reciprocal chromosome aneuploidy are almost always euploid.
Forman EJ Treff NR Stevens JM Garnsey HM Katz-Jaffe MG Scott RT Schoolcraft WB
Hum Reprod, 28:502-8, 2013. - Sperm DNA fragmentation index does not correlate with the sperm or embryo aneuploidy rate in recurrente miscarriage or implantation failure patients.
Bronet F Martínez E Gaytan M Liñán A Cernuda D Ariza M Nogales M Pacheco A San celestino M García-Velasco JA
Hum Reprod 27: 1922-9, 2012 - Characteristics of chromosomal abnormalities diagnosed after spontaneous abortions in an infertile population.
Werner MD Reh A Grifo J Perle MA
J Assist Reprod Genet. May 2012. J Assist Reprod Genet. August 2012; 29 (8); 817-20. - Successful Live Birth following Preimplantation Genetic Diagnosis for Phenylketonuria in Day 3 Embryos by Specific Mutation Analysis and Elective Single Embryo Transfer.
Lavery S Abdo D JIMD Reports Kotrotsou M Trew G Konstantinidis M Wells D
JIMD Reports, 7:49–54, 2012. - Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLC?) from an infertile man by use of minisequencing of individual sperm and expression in somatic
Kashir J Konstantinidis M Jones C Heindryckx B Sutter P De Parrington J Wells D Coward K
Fertil Steril, 98:423–431, 2012. - Alteration of gene expression in human cumulus cells as a potential indicator of oocyte aneuploidy.
Fragouli E Wells D Iager AE Kayisli UA Patrizio P
Hum Reprod, 27:2559–2568, 2012. - Aneuploidy Screening for Embryo Selection.
Fragouli E Wells D
Semin Reprod Med, 30:289–301, 2012. - Transcriptomic analysis of follicular cells provides information on the chromosomal status and competence of unfertilized oocytes.
Fragouli E Wells D
Expert Rev Mol Diagn, 12:1–4, 2012. - Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes.
Munné S Held KR Magli CM Ata B Wells D Fragouli E Baukloh V Fischer R Gianaroli L
Fertil Steril, 97:935–942, 2012. - Preimplantation genetic diagnosis (PGD), preimplantation genetic screening (PGS) and the transfer of in vitro fertilized embryos.
Wells D
In Brenner’s Online Encyclopedia of Genetics (Elsevier). Edited by Maloy S, Hughes K. 2012. - Sperm DNA fragmentation index does not correlate with the sperm or embryo aneuploidy rate in recurrent miscarriage or implantation failure patients.
Bronet F Martínez E Gaytán M Liñán A Cernuda D Ariza M Nogales M Pacheco A San Celestino M García-Velasco JA
Hum Reprod, 27:1922-29, 2012 - Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS.
Castillo JC García-Velasco JA Humaidan P
J Assist Reprod Genet. 29:249-53, 2012. - Hepatitis B virus in human oocytes and embryos
Garrido N Bellver J Rubio C Pellicer A
Hum Reprod, 27:1227-1228, 2012. - Consistent and predictable delivery rates after oocyte vitrification: an observationallongitudinal cohort multicentric study.
Muñoz E Bosch E Fernandez I Portela S Ortiz G Remohí J Pellicer A
Hum Reprod, 13(3):409-16; 2012. - Chromosomal abnormalities in embryos from couples with a previous aneuploid miscarriage.
Al-Asmar N Peinado V Vera M Remohí J Pellicer A Simón C Hassold T Rubio C
Fertil Steril, 98(1);145-50, 2012. - Comprehensive chromosome screening and embryo selection: moving toward single euploid blastocyst transfer.
Forman EJ Hong KH Treff NR Scott RT
Semin Reprod Med, 30:236-42, 2012. - Methods for comprehensive chromosome screening of oocytes and embryos: capabilities, limitations, and evidence of validity.
Scott RT
J Assist Reprod Genet, 29:381-90, 2012 - Delivery of a chromosomally normal child from an oocyte with reciprocal aneuploid polar bodies.
Scott RT Treff NR Stevens J Forman EJ Hong KH Katz-Jaffe MG Schoolcraft WB
J Assist Reprod Genet, 29:533-7, 2012. - Blastocyst preimplantation genetic diagnosis of a mitochondrial DNA disorder.
Treff NR Tao X Campos J Su J Ferry KM Levy B Scott RT
Fertil Steril, 98:1236-1240, 2012. - Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study.
Scott RT Ferry KM Su J Tao X Scott KL Treff NR
Fertil Steril, 97:870-875, 2012. - Development and validation of an accurate quantitative real-time polymerase chain reaction – based assay for human blastocyst comprehensive chromosomal aneuploidy screening. Seminal Contribution.
Treff NR Tao X Ferry KM Su J Taylor D Scott RT
Fertil Steril, 97:819-824, 2012. - Single embryo transfer with comprehensive chromosome screening results in improved ongoing pregnancy rates and decreased miscarriage rates.
Forman EJ Tao X Ferry KM Taylor D Treff NR Scott RT
Human Reproduction, 27:1217- 22, 2012. - Self-correction in tripronucleated human embryos.
Grau N Escrich L Martín J Rubio C Pellicer A Escribà MJ
Fertil Steril, 96(4):951-6, 2011. - A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC?) leads to male infertility.
Kashir J Konstantinidis M Jones C Lemmon B Lee HC Hamer R Heindryckx B Deane CM De Sutter P Fissore RA Parrington J Wells D Coward K
Hum Reprod, 27:222–231, 2011. - The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy.
Fragouli E Alfarawati S Goodall N Sanchez-Garcia JF Colls P Wells D
Mol Hum Reprod, 17:286–295, 2011. - First births after preimplantation genetic diagnosis of structural chromosome abnormalities using comparative genomic hybridization and microarray analysis.
Alfarawati S Fragouli E Colls P Wells D
Hum Reprod, 26:1560–1574, 2011. - Chromosome Abnormalities in the Human Oocyte.
Fragouli E Wells D Delhanty J
Cytogenet Genome Res, 133:107–118, 2011 - PGD and aneuploidy screening for 24 chromosomes: advantages and disadvantages of competing platforms.
Bisignano A Wells D Harton G Munné S
Reprod Biomed Online, 23:677–685, 2011. - Aneuploidy in the Human Blastocyst
Fragouli E Wells D
Cytogenet Genome Res, 133:149–159, 2011. - Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos.
Gutiérrez-Mateo C Colls P Sánchez-Garcia J Escudero T Prates R Ketterson K Wells D Munné S
Fertil Steril, 95:953–958, 2011. - Therapeutic treatments of mtDNA diseases at the earliest stages of human development.
Chiaratti MR Meirelles FV Wells D Poulton J
Mitochondrion, 11:820–828, 2011. - Cumulative live-birth rates per total number of embryos needed to reach newborn in consecutive in vitro fertilization (IVF) cycles: a new approach to measuring the likelihood of IVF success.
Garrido N Bellver J Remohí J Simón C Pellicer A
Fertil Steril, 96:40-46, 2011. - Effect of sperm DNA fragmentation on pregnancy outcome depends on oocyte quality
Meseguer M Santiso R Garrido N García-Herrero S Remohí J Fernandez JL
Fertil Steril, 95:124-128, 2011. - Fertility after age 45: From natural conception to assisted reproductive technology and beyond.
Forman EJ Treff NR Scott RT
Maturitas, 70:216-221, 2011. - Telomere DNA deficiency is associated with development of human embryonic aneuploidy.
Treff NR Su J Taylor D Scott RT
PLoS Genetics, 7: e1002161, 2011 - SNP Microarray Based Concurrent Screening of 24 Chromosome Aneuploidy and Unbalanced Translocations in Preimplantation Human Embryos.
Treff NR Northrop L Kasabwala K Su J Levy B Scott RT
Fertil Steril, 95:1606-1612, 2011. - Surgical management of tubal disease and infertility
Coughlan C TC Li
Obstetrics, Gynaecology and Reproductive Medicine, Vol 19, 2010. - Blood group and ovarian hyperstimulation syndrome.
Bellver J Ferrando M Garrido N Pellicer A
Fertil Steril, 93:270-1, 2010. - Accurate single cell 24 chromosome aneuploidy screening using whole genome amplification and single nucleotide polymorphism microarrays.
Treff NR Su J Tao X Levy B Scott RT
Fertil Steril, 94: 2017-2021, 2010. - GnRH agonist administration at the time of implantation does not improve pregnancy outcome in intrauterine insemination cycles: a randomized controlled tria
Bellver J E Labarta Bosch E Melo MAB Vidal C Remohí J Pellice A
Fertil Steril 94(3):1065-71, 2010. - Severe Refractory Hidradenitis Suppurativa in HIV-Positive Patient Successfully Treated with Infliximab.
Alecsandru D Padilla B Avilés Izquierdo JA Fernández- Cruz E Sánchez-Ramón S
Archives of Dermatology. Dec; 146(12):1343-5.2010 - Impacto de un complejo de antioxidantes sobre la fragmentación del ADN espermático en varones infértiles
Balmori C Areces C Pacheco A San Celestino M García-Velasco JA
Rev Int Androl 8: 107-13, 2010 - Cytogenetic analysis of human blastocysts with the use of FISH, CGH and aCGH: scientific data and technical evaluation.
Fragouli E Alfarawati S Daphnis D Goodall N Mania A Griffiths T Gordon T Wells D
Hum Reprod, 26:480–490, 2010. - Transmission of Mitochondrial DNA Diseases and Ways to Prevent Them.
Poulton J Chiaratti MR Meirelles FV Kennedy S Wells D Holt IJ
PLoS Genet, 6, 2010. - Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes.
Munné S Wells D Cohen J
Fertil Steril, 94:408–430, 2010. - Microarrays and CGH for PGD of chromosome abnormalities and gene defects.
Munné S Harton G Held K Wells D
Journal of Reproductive Medicine and Endocrinology, 7:236-239, 2010 - Embryo aneuploidy and the role of morphological and genetic screening.
Wells D
Reprod Biomed Online, 21:274–277, 2010. - Transcriptomic profiling of human oocytes: association of meiotic aneuploidy and altered oocyte gene expression.
Fragouli E Bianchi V Patrizio P Obradors A Huang Z Borini A Delhanty J Wells D
Mol Hum Reprod, 16:570–582, 2010. - Improved detection of aneuploid blastocysts using a new 12-chromosome FISH test.
Munné S Fragouli E Colls P Katz-Jaffe MG Schoolcraft WB Wells D
Reprod Biomed Online, 20:92–97, 2010. - Y chromosome microdeletions, sperm DNA fragmentation and sperm oxidative stress as causes of recurrent spontaneous abortion of unknown etiology.
Bellver J Meseguer M Muriel L Garcia-Herrero S Barreto MAM Garda AL Remohí J Pellicer A Garrido N
Hum Reprod, 25:1713-1721, 2010. - Improving FISH diagnosis for preimplantation genetic aneploidy screening
Mir P Rodrigo L Mateu E Milán M Mercader A Buendía P Delgado A Pellicer A Remohí J Rubio C
Human Reprod, 25(7); 1812-7, 2010. - Aneploidies in embryos and spermatozoa from patients with Y chromosome microdelections.
Mateu E Rodrigo L Martínez MC Peinedo V Delagado A MIr P Simón C Remohí J
Reprod Biomed Online, 21(5); 649-57, 2010. - Single Cell Whole Genome Amplification Technique Impacts the Accuracy of SNP Microarray Based Genotyping and Copy Number Analyses.
Treff NR Su J Tao X Northrop L Scott RT
Mol Hum Repro, 17: 335–343, 2010. - SNP microarray based 24 chromosome aneuploidy screening demonstrates that cleavage stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts.
Northrop L Treff NR Levy B Scott RT
Mol Hum Repro, 16:590-600, 2010. - SNP microarray based 24 chromosome aneuploidy screening is significantly more consistent than FISH.
Treff NR Levy B Su J Northrop L Tao X Scott RT
Mol Hum Repro, 16:583-9, 2010. - Assessing the reproductive competence of individual embryos: a proposal for the validation of new "-omics" technologies.
Scott RT Treff NR
Fertil Steril, 94:791-794, 2010. - Robust embryo identification using polar body single nucleotide polymorphism microarray based DNA fingerprinting.
Treff NR Su J Kasabwala N Tao X Miller KA Scott RT
Fertil Steril, 93: 2453-2455, 2010. - The p53 codon 72 single nucleotide polymorphism lacks a significant effect on implantation rate in fresh in vitro fertilization cycles: an analysis of 1,056 patients.
Patounakis G Treff N Tao X Lonczak A Scott RT Frattarelli JL
Fertil Steril, 92:1290-6. 2009. - Comparative genomic hybridization of oocytes and first polar bodies from young donors.
Fragouli E Escalona A Gutiérrez-Mateo C Tormasi S Alfarawati S Sepulveda S Wells D Munné S
Reprod Biomed Online, 19:228–237, 2009. - Vitrification of preimplantation genetically diagnosed human blastocysts and its contribution to the cumulative ongoing pregnancy rate per cycle by using a closed device
Escribà MJ Zulategui JF Galán A Mercader A Remohí J De Los Santos MJ
Fertil Steril, 89(4):840-6, 2008 - Técnica de B-Lynch en el control de la hemorragia posparto Progresos de Obstetricia
Blanco M Gómez E Manosalvas P Izquierdo A Puente J Hernández García JM
Ginecología Volumen 51,(9), 513-519, 2008. - Birth of a healthy boy after a double factor PGD in a couple carrying a genetic disease and at risk for aneuploidy.
Obradors A Fernandez E Oliver-Bonet M Rius M de la Fuente A Wells D Benet J Navarro J
Hum Reprod, 23:1949–1956, 2008. - Evaluation of embryo quality by Metabolomics: A new strategy to aid single embryo transfer.
Sakkas D Morita H Yamashita N Kato LO Botros L Roos P Seli E
J Mammal Ova Res. 25:26-31, 2008. - Soluble vascular endothelial-cadherin levels correlate with clinical and biological aspects of severe ovarian hyperstimulation syndrome.
Villasante A Pacheco A Pau E Ruiz A Pellicer A García-Velasco JA
Hum Reprod. 23:662-7, 2008. - Artículo de revisión "Diagnóstico por imagen”
Puente J Grañeras A Requena A
Cuadernos de Medicina Reproductiva, 13( 2) : 37-51, 2007. - Sperm selection by swim-up in terms of deoxyribonucleic acid fragmentation as measured by the sperm chromatin dispersion test is altered in heavy smokers.
Viloria T Garrido N Fernández JL Remohí J Pellicer A Meseguer M
Fertil Steril, 88:523-525, 2007. - Single cell diagnosis using comparative genomic hybridization after preliminary DNA amplification still needs more tweaking: too many miscalls.
Fragouli E Delhanty JD Wells D
Fertil Steril, 88:247–248, 2007. - J.Ultrastructure of preimplantation genetic diagnosis-derived human blastocysts grown in a coculture system after vitrification.
Escribà MJ Escobedo-Lucea C Mercader A De Los Santos MJ Pellicer A Remohí J
Fertil Steril, 86(3):664-71, 2006 - Heteroparental blastocyst production from microsurgically corrected tripronucleated human embryos.
Escribà MJ Martín J Rubio C Valbuena D Remohí J Pellicer A Simón C
Fertil Steril, 86(6):1601-7, 2006. - Prenatal management of placental chorioangioma: value of the middle cerebral artery peak systolic velocity.
Escribano D Galindo A Arbués J Puente J De la Fuente P
Fetal Diagn Ther, 21(6):489-93, 2006. - Use of Real-Time Polymerase Chain Reaction to Measure Gene Expression in Single Cells.
Wells D
In Single Cell Diagnostics: Methods and Protocols (Humana Press, USA), p125-134. Edited by Thornhill, A. 2006. - A successful strategy for Preimplantation Genetic Diagnosis of betathalassemia and simultaneous detection of Down's syndrome using multiplex fluorescent PCR.
Piyamongkol W Vutyavanich T Piyamongkol S Wells D Kunaviktikul C Tongsong T Chaovisitsaree S Saetung R Sanguansermsri T
J Med Assoc Thai, 89:918-27, 2006. - Estudio comparativo de dos medios de cultivo HTF e ISM-1: implicaciones en el fenotipo embrionario y resultados clínicos.
Gimeno L Lopez MA Meseguer M Santos JM Pellicer A Remohí J Santos MJ
Revista Iberoamericana de Fertilidad y Reproducción Humana, 23: 375-382, 2006. - Etiologia, diagnostico y manejo del hidrops fetal: revision de 140 casos
Arbués J Galindo A Puente J Grañeras A De la Fuente P
Prog Obstet Ginecol 48:225-230, 2005. - Isolated unilateral pulmonary agenesis. Early prenatal diagnosis and long-term follow up.
Arbués J Galindo A Rasero M Orbea C Puente J De la Fuente P
J Ultrasound Med, 24: 865-8, 2005. - The singleton, term gestation, and live birth rate per cycle initiated: a 1-year experience in in vitro fertilization cycles with native and donated oocytes.
Bellver J Albert C Soares SR Alvarez C Pellicer A
Fertil Steril, 83:1404-9, 2005. - Near Speed-of-Light On-Chip Interconnects Using Pulsed Current-Mode Signaling.
Jose AP Patounakis G Shepard KL
2005 Symposium on VLSI Circuits, 108-11. 2005. - Association of abnormal morphology and altered gene expression in human preimplantation embryos.
Wells D Bermúdez MG Steuerwald N Malter HE Thornhill AR Cohen J
Fertil Steril, 84:343–355, 2005. - Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation development.
Wells D Bermudez MG Steuerwald N Thornhill AR Walker DL Malter H Delhanty JDA Cohen J
Hum Reprod, 20:1339–1348, 2005. - Reliability of comparative genomic hybridization to detect chromosome abnormalities in first polar bodies and metaphase II oocytes.
Gutiérrez-Mateo C Wells D Benet J Sánchez-García JF Bermúdez MG Belil I Egozcue J Munné S Navarro J
Hum Reprod, 19:2118–2125, 2004. - Advances in preimplantation genetic diagnosis.
Wells D
Eur J Obstet Gynecol Reprod Biol, 115:S97-S101, 2004. - Rabbit and pig ear skin sample cryobanking: effects of storage time and temperature of the whole ear extirpated immediately after death.
Silvestre MA Saeed AM Cervera RP Escribà MJ García-Ximénez F
Theriogenology, 59(5-6):1469-77, 2003. - Detailed investigation of factors influencing amplification efficiency and allele drop-out in single cell PCR: implications for preimplantation genetic diagnosis.
Piyamongkol W Bermudez MG Harper JC Wells D
Mol Hum Reprod, 9:411–420, 2003. - Single-cell sequencing and mini-sequencing for preimplantation genetic diagnosis.
Bermudez MG Piyamongkol W Tomaz S Dudman E Sherlock JK Wells D
Prenat Diagn, 23:669–677, 2003. - Viable offspring derived from cryopreserved haploid rabbit parthenotes
García-Ximénez F Escribà MJ
Theriogenology, 57(4):1319-25, 2002 - New techniques on embryo manipulation.
Escribà MJ Valbuena D Remohí J Pellicer A Simón C
J Reprod Immunol, 55(1-2):149-61. Review, 2002 - Vitrification and rapid freezing of rabbit fetal tissues and skin samples from rabbits and pigs.
Silvestre MA Saeed AM Escribà MJ García-Ximénez F
Theriogenology, 58 (1):69-76, 2002. - Preimplantation genetic diagnosis: an alternative to prenatal diagnosis.
Delhanty JDA Wells D
Expert Rev Mol Diagn, 2:395–399, 2002. - First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy.
Wells D Escudero T Levy B Hirschhorn K Delhanty JDA Munné S
Fertil Steril, 78:543–549, 2002. - Preimplantation genetic diagnosis for single gene disorders: experience with five single gene disorders.
Harper JC Wells D Piyamongkol W Abou-Sleiman P Apessos A Ioulianos A Davis M Doshi A Serhal P Ranieri M Rodeck C Delhanty JDA
Prenat Diagn, 22:525–533, 2002. - Towards a comprehensive analysis of chromosomes and DNA sequences in human embryos.
Wells D
In Advances in Infertility Treatment (Monduzzi Editore, Italy), p459-473. Edited by Filicori M. 2002. - The "vanishing embryo" phenomenon in an oocyte donation programme.
Rodríguez-González M Serra V García-Velasco JA Pellicer A Remohí J
Fertil Steril. 77:542-7, 2002. - Comparison of the effect of two different handling media on rabbit zygote developmental ability
Escribà MJ Silvestre MA Saeed AM García-Ximénez F
Reprod Nutr Dev, 41(2):181-6, 2001. - Acrocentric chromosome disomy is increased in spermatozoa from fathers of Turner syndrome patients
Soares SR Vidal F Bosch M Martínez-Pasarell O , Nogués C Egozcue J Templado C
Hum Genet, 108:499-503, 2001 - Numerical chromosome abnormalities in the spermatozoa of the fathers of children with trisomy 21 of paternal origin: generalised tendency to meiotic non-disjunction.
Soares SR Templado C Blanco J Egozcue J Vidal F
Hum Genet, 108:134-39, 2001. - Preimplantation genetic diagnostic protocols for alpha- and beta-thalassaemias using multiplex fluorescent PCR.
Piyamongkol W Harper JC Delhanty JDA Wells D
Prenat Diagn, 21:753–759, 2001. - PGD protocols using multiplex fluorescent PCR.
Piyamongkol W Harper CJ Delhanty JDA Wells D
Reprod Biomed Online, 2:212–214, 2001. - A successful strategy for preimplantation genetic diagnosis of myotonic dystrophy using multiplex fluorescent PCR.
Piyamongkol W Harper JC Sherlock JK Doshi A Serhal PF Delhanty JDA Wells D
Prenat Diagn, 21:223–232, 2001 - Genetic alterations in gastric cancers from British patients.
Sud R Wells D Talbot IC Delhanty JDA
Cancer Genet Cytogenet, 126:111–119, 2001. - Preimplantation genetic diagnosis: applications for molecular medicine.
Wells D Delhanty JDA
Trends Mol Med, 7:23–30, 2001 - Future developments in preimplantation genetic diagnosis.
Harper J Wells D
In Preimplantation Genetic Diagnosis (John Wiley & Sons, UK) p241-262. Edited by Harper J, Delhanty J, Handyside A. 2001. - Vitrification and rapid-freezing of cumulus cells from rabbits and pigs.
Saeed AM Escribà MJ Silvestre MA Garcia-Ximénez F
Theriogenology, 54(9):1359-71, 2000. - Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization.
Wells D Delhanty JDA
Mol Hum Reprod, 6:1055–1062, 2000. - A successful strategy for preimplantation diagnosis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency.
Ioulianos A Wells D Harper JC Delhanty JDA
Prenat Diagn, 20:593–598, 2000. - Comparative Genomic Hybridization Reveals Extensive Variation Among Different MCF-7 Cell Stocks.
Jones C Payne J Wells D Delhanty JDA Lakhani SR Kortenkamp A
Cancer Genet Cytogenet, 117:153–158, 2000. - Deletion and duplication of the adenomatous polyposis coli gene resulting from an interchromosomal insertion involving 5 (q22q23.3) in the father.
Hastings RJ Svennevik EC Setterfield B Wells D Delhanty JDA Mackinnon H
J Med Genet, 37:141–145, 2000. - Positive outcome after preimplantation diagnosis of aneuploidy in human embryos.
Munne S Magli C Cohen J Morton P Sadowy S Gianaroli L Tucker M Marquez C Sable D Ferraretti AP Massey JB Scott RT
Human Reprod, 14:2191-9, 1999. - Strategies for preimplantation genetic diagnosis of single gene disorders by DNA amplification.
Wells D Sherlock JK
Prenat Diagn, 18:1389–1401, 1998. - Preimplantation genetic diagnosis of cancer: familial adenomatous polyposis coli (FAPC).
Ao A Wells D Handyside AH Winston RML Delhanty JDA
J Assist Reprod Genet, 15:140–144, 1998. - Genetic diagnosis before implantation.
Delhanty JDA Wells D Harper JC
BMJ, 315:828–829, 1997. - Detection of haemoglobinopathies and chromosome aneuploidy from minute DNA samples using multiplex PCR.
Sherlock J Cirigliano V Petrou M Wells D Adinolfi M
In Infertility and Assisted Reproductive Technology - From Research to Therapy (Monduzzi Editore, Italy) p203-211. Edited by Ambrosini A, Melis GB, Dalla Pria S, Dessole S. 1997. - APC gene mutation and DNA microsatellite instability in pancreatic cancers of UK origin.
See CG Sud R Wells D Bowles L Ding S Habib N Delhanty JDA
GI Cancer 2, 133-137, 1996. - Preimplantation genetic diagnosis of beta-thalassaemia.
El-Hashemite N Wells D Delhanty JDA
Lancet, 348:620–621, 1996. - Rapid detection of rare variants and common polymorphisms in the APC gene by PCR-SSCP for presymptomatic diagnosis and showing allele loss.
Gayther SA Sud R Wells D Tsioupra K Delhanty JD
J Med Genet, 32:568–571, 1995. - Correlation of loss of heterozygosity with cytogenetic analysis using g-banding and fluorescence in situ hybridization in aneuploid cultures from two human testicular germ-cell tumors.
Al-Jehani RMA Wells D Fox M Parrington JM
Cancer Genet Cytogenet, 85:26–36, 1995. - Prognostic value of blastocyst grade after frozen euploid embryo transfer in patients with recurrent pregnancy loss.
Gayathree Murugappan G.Kim J Jonathan D.Kort Brent M.Hanson Shelby A.Neal W.Tiegs A K.Osman E Scott RT Lathi R B
F&S ReportsIn press, journal pre-proofAvailable online 9 July 2020 - Clinical error rates of next generation sequencing and array comparative genomic hybridization with single thawed euploid embryo transfer.
Jenna Friedenthal M.Maxwell S W.Tiegs A G. Besser A McCaffrey C Munné S Noyes N A.Grifo J
Eur J Med Genet. 2020 Jan 20:103852. doi: 10.1016/j.ejmg.2020.103852. [Epub ahead of print] - Intracytoplasmic sperm injection is not superior to conventional IVF in couples with non-male factor infertility and preimplantation genetic testing for aneuploidies (PGT-A).
De Munck N El Khatib I Abdala A El-Damen A Bayram A Arnanz A Melado L Lawrenz B Fatemi HM
Hum Reprod. 2020 Feb 29;35(2):317-327. doi: 10.1093/humrep/deaa002. - Term oocyte maturation and term ovarian stimulation: impact on oocyte competence.
Dozortsev DI Pellicer A Diamond MP
Fertil Steril. 2020 Jul 1:S0015-0282(20)30341-1. doi: 10.1016/j.fertnstert.2020.04.013. Online ahead of print. - The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers.
Reig A Franasiak J Scott RT Seli E
J Assist Reprod Genet. 2020 Mar 16. doi: 10.1007/s10815-020-01739-0. [Epub ahead of print] - Human female meiosis checkpoints: how much DNA damage is allowed?
Fragouli E Garrrido N
Fertil Steril. 2020 May;113(5):943-944. doi: 10.1016/j.fertnstert.2020.01.023. Epub 2020 Mar 20. - Mitochondrial DNA content is not predictive of reproductive competence in euploid blastocysts.
Scott RT Sun L Zhan Y Marin D Tao X Seli E
Reprod Biomed Online. 2020 May 14:S1472-6483(20)30193-0. doi: 10.1016/j.rbmo.2020.04.011. Online ahead of print. - Blastocyst mitochondrial DNA (mtDNA) is not affected by oocyte vitrification: a sibling oocyte study.
Arnanz A De Munck N Bayram A El-Damen A Abdalla A ElKhatib I Melado L Lawrenz B Fatemi HM
J Assist Reprod Genet. 2020 Jun;37(6):1387-1397. doi: 10.1007/s10815-020-01795-6. Epub 2020 May 6. - ESHRE PGT Consortium and SIG Embryology good practice recommendations for polar body and embryo biopsy for PGT.
ESHRE PGT Consortium and SIG-Embryology Biopsy Working Group Kokkali G Coticchio G Bronet F Celebi C Cimadomo D Goossens V Liss J Nunes S Sfontouris I Vermeulen N Zakharova E De Rycke M
Hum Reprod Open. 2020 May 29;2020(3):hoaa020. doi: 10.1093/hropen/hoaa020. eCollection 2020. - Interchromosomal effect in carriers of translocations and inversions assessed by preimplantation genetic testing for structural rearrangements (PGT-SR).
Mateu-Brull E Rodrigo L Peinado V Mercader A Campos-Galindo I Bronet F García-Herrero S Florensa M Milán M Rubio C
J Assist Reprod Genet. 2019 Dec;36(12):2547-2555. doi: 10.1007/s10815-019-01593-9. Epub 2019 Nov 6. - Time of morulation and trophectoderm quality are predictors of a live birth after euploid blastocyst transfer: a multicenter study.
Rienzi L Cimadomo D Delgado A Minasi MG Fabozzi G Gallego RD Stoppa M Bellver J Giancani A Esbert M Capalbo A Remohí J Greco E Ubaldi FM Messeguer M
Fertil Steril. 2019 Dec;112(6):1080-1093.e1. doi: 10.1016/j.fertnstert.2019.07.1322. - Erratum. Worth the wait? Day 7 blastocysts have lower euploidy rates but similar sustained implantation rates as Day 5 and Day 6 blastocysts.
Tiegs AW Sun L Patounakis G Scott RT
Hum Reprod. 2019 Nov 26. pii: dez219. doi: 10.1093/humrep/dez219. [Epub ahead of print] No abstract available. - Interchromosomal effect in carriers of translocations and inversions assessed by preimplantation genetic testing for structural rearrangements (PGT-SR).
Mateu-Brull E Rodrigo L Peinado V Mercader A Campos-Galindo I Bronet F García-Herrero S Florensa M Milán M Rubio C
J Assist Reprod Genet. 2019 Nov 6. doi: 10.1007/s10815-019-01593-9. [Epub ahead of print] - Reply: Careful and expert interpretation of PGT-A data can resolve the mosaicism dilemma.
Lawrenz B El-khatib I Fatemi HM
Hum Reprod. 2019 Nov 11. pii: dez176. doi: 10.1093/humrep/dez176. [Epub ahead of print] No abstract available. - Second-generation preimplantation genetic testing for aneuploidy in assisted reproduction: a SWOT analysis.
Bellver J Bosch E Espinós J García-Velasco JA Fabregues F Fontes J Llácer J Requena A Checa MA
Reprod Biomed Online. 2019 Aug 13. pii: S1472-6483(19)30695-9. doi: 10.1016/j.rbmo.2019.07.037. [Epub ahead of print] Review. - Clinical outcomes after the transfer of blastocysts characterized as mosaic by high resolution Next Generation Sequencing- further insights.
Munné S Spinella F Grifo J Zhang J Beltran MP Fragouli E Fiorentino F
Eur J Med Genet. 2019 Aug 21:103741. doi: 10.1016/j.ejmg.2019.103741. [Epub ahead of print] - Worth the wait? Day 7 blastocysts have lower euploidy rates but similar sustained implantation rates as Day 5 and Day 6 blastocysts.
Tiegs AW Sun L Patounakis G Scott RT
Hum Reprod. 2019 Aug 12. pii: dez138. doi: 10.1093/humrep/dez138. [Epub ahead of print] - mtDNA dynamics between cleavage-stage embryos and blastocysts.
De Munck N Liñan A Elkhatib l Bayram A Arnanz A Rubio C Garrido N Lawrenz B Fatemi HM
J Assist Reprod Genet. 2019 Aug 7. doi: 10.1007/s10815-019-01544-4. [Epub ahead of print] - Preimplantation genetic screening for aneuploidy (PGT-A 2.0) in assisted reproduction: A SWOT analysis
J. Bellver E-Bosch JJ Espinós F.Fabregues J. Fontes J. García-Velasco J. Llácer A. Requena MA Checa
Reproductive BioMedicine Online, In press, journal pre-proof, Available online 16 May 2019 - PGDIS Position Statement on the Transfer of Mosaic Embryos 2019.
Cram DS Leigh D Handyside A Rechitsky L Harton G Grifo J Rubio C Fragouli E Kahraman S Katz-Jaffe M Tempest H Thornhill A Strom C Escudero T Qiao J Munne S Simpson JL Kuliev A
Reprod Biomed Online. 2019 Aug;39 Suppl 1:e1-e4. doi: 10.1016/j.rbmo.2019.06.012. No abstract available. - When next-generation sequencing-based preimplantation genetic testing for aneuploidy (PGT-A) yields an inconclusive report: diagnostic results and clinical outcomes after re biopsy.
Neal SA Sun L Jalas C Morin SJ Molinaro T Scott RT
J Assist Reprod Genet. 2019 Aug 30. doi: 10.1007/s10815-019-01550-6. [Epub ahead of print] - Segmental aneuploidy in human blastocysts: a qualitative and quantitative overview.
Escribà MJ Vendrell X Peinado V
Reprod Biol Endocrinol. 2019 Sep 16;17(1):76. doi: 10.1186/s12958-019-0515-6. - Ovarian Stimulation (OS) Does Not Influence the Uterine Immune Environment in Healthy Infertile Women
D. Alecsandru A. Pacheco A. Guerrero-Mayo A. Fabris P. Aparicio A. Barrio Pellicer A Juan A García-Velasco
Reproductive BioMedicine Online, In press, journal pre-proof, Available online 22 August 2019 - Embryonic aneuploidy rates are equivalent in natural cycles and gonadotropin-stimulated cycles.
Hong KH Franasiak JM Patounakis G Juneau CR Scott RT
Fertil Steril. 2019 Oct;112(4):670-676. doi: 10.1016/j.fertnstert.2019.05.039. - Divining the genetic status of embryos: consult the medium?
Dhruti Babariya D.Phil Megan Leaver M Dagan Wells
Fertility and Sterility, In press, corrected proof,Available online 29 July 2019 - Cleavage stage mitochondrial DNA is correlated with preimplantation human embryo development and ploidy status.
Bayram A De Munck N Elkhatib I Arnanz A Liñán A Lawrenz B Fatemi HM
J Assist Reprod Genet. 2019 Jul 10. doi: 10.1007/s10815-019-01520-y. [Epub ahead of print] - Embryonic Aneuploidy after Preimplantation Genetic Screening: Age- and Indication-Matched Comparative Study between Indian and Spanish Population.
Kotdawala A Mir P Herrero J Khajuria R Lalitkumar PGL Banker MR
J Hum Reprod Sci. 2019 Apr-Jun;12(2):141-149. doi: 10.4103/jhrs.JHRS_109_18. - Transcriptomic behavior of genes associated with chromosome 21 aneuploidies in early embryo development.
Sanchez-Ribas I Diaz-Gimeno P Sebastián-León P Mercader A Quiñonero A Ballesteros A Pellicer A Domínguez F
Fertil Steril. 2019 May;111(5):991-1001.e2. doi: 10.1016/j.fertnstert.2019.01.023. Epub 2019 Mar 25 - The clinicians´ dilemma with mosaicism-an insight from inner cell mass biopsies.
Lawrenz B El Khatib I Liñán A Bayram A Arnanz A Chopra R De Munck N Fatemi HM
Hum Reprod. 2019 May 22. pii: dez055. doi: 10.1093/humrep/dez055. [Epub ahead of print] - The preimplantation genetic testing debate continues: first the hype, then the tension, now the hypertension?
Patounakis G Hill MJ
Fertil Steril. 2019 May 27. pii: S0015-0282(19)30407-8. doi: 10.1016/j.fertnstert.2019.04.028. [Epub ahead of print] No abstract available. - Gene Editing Should Replace Embryo Selection Following PGD.
Wells D Vermeesch JR Simpson JL
Prenat Diagn. 2019 Mar 4. doi: 10.1002/pd.5442. [Epub ahead of print] No abstract available. - Mitochondria as a Biomarker for IVF Outcome.
Kim J Seli E
Reproduction. 2019 Mar 1. pii: REP-18-0580.R2. doi: 10.1530/REP-18-0580. [Epub ahead of print] Review. - Mitochondrial DNA copy number as a predictor of embryo viability.
Cecchino GN Garcia-Velasco JA
Fertil Steril. 2019 Feb;111(2):205-211. doi: 10.1016/j.fertnstert.2018.11.021. Epub 2019 Jan 2. Review. - Mosaic embryos present a challenging clinical decision.
Osman EK Werner MD
Fertil Steril. 2019 Jan;111(1):52-53. doi: 10.1016/j.fertnstert.2018.10.032. No abstract available. - The cytogenetic constitution of human blastocysts: insights from comprehensive chromosome screening strategies.
Fragouli E Munne S Wells D
Hum Reprod Update. 2019 Jan 1;25(1):15-33. doi: 10.1093/humupd/dmy036. - The model of "genetic compartments": a new insight into reproductive genetics.
Vendrell X Escribà MJ
J Assist Reprod Genet, NA:NA-NA, 2018. - Preimplantation genetic testing for aneuploidy is cost-effective, shortens treatment time, and reduces the risk of failed embryo transfer and clinical miscarriage.
Neal SA Morin SJ Franasiak JM Goodman L Juneau CR Forman EJ Werner MD Scott RT
Fertil Steril, 110(5):896-904, 2018. - Quest for a less invasive approach to preimplantation genetic testing remains ongoing
Neal SA Werner MD
Fertil Steril, 110(5):854-856, 2018. - Minimizing mosaicism: assessing the impact of fertilization method on rate of mosaicism after next-generation sequencing (NGS) preimplantation genetic testing for aneuploidy (PGT-A).
Palmerola KL Vitez SF Amrane S Fischer CP Forman EJ
J Assist Reprod Genet, NA:NA-NA, 2018. - The model of "genetic compartments": a new insight into reproductive genetics.
Vendrell X Escribà MJ
J Assist Reprod Genet, doi: 10.1007/s10815-018-1366-3.2018 - The Status of Genetic Screening in Recurrent Pregnancy Loss.
Kaser DJ
Obstet Gynecol Clin North Am, 45(1):143-154, 2018. - What to do when good-quality embryos repeatedly fail to implant.
Coughlan C
Best Pract Res Clin Obstet Gynaecol, 53:48-59, 2018. - Pregnancy after vasectomy: surgical reversal or assisted reproduction?
Valerie U De Brucker S De Brucker M Vloeberghs V Drakopoulos P Santos-Ribeiro S Tournaye H
Tournaye H.Hum Reprod, 1;33(7):1218-27, 2018. - Does the type of GnRH analogue used, affect live birth rates in women with endometriosis undergoing IVF/ICSI treatment, according to the rAFS stage?
Drakopoulos P Rosetti J Pluchino N Blockeel C Santos-Ribeiro S de Brucker M Drakakis P Camus M Tournaye H Polyzos NP
Gynecol Endocrinol, 12:1-6, 2018. - Premature progesterone elevation: targets and rescue strategies.
Lawrenz B Labarta E Fatemi HM Bosch E
Fertil Steril, 109(4):577-582, 2018. - The impact of contemporary preimplantation genetic screening and diagnosis on the detection of aneuploidy and inherited genetic diseases.
Neal SA Werner MD
Birth Defects Res, 110(8):644-647, 2018. - Next generation sequencing for preimplantation genetic testing for aneuploidy: friend or foe?
Fragouli E
Fertil Steril, 109(4):606-607, 2018. - Very low anti-müllerian hormone concentrations are not an independent predictor of embryo quality and pregnancy rate.
Pacheco A Cruz M Iglesias C García-Velasco JA
Reprod Biomed Online, 37(1):113-119, 2018. - Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos.
Wang T Babayev E, Jiang Z Li G Zhang M Esencan E Horvath T Seli E
Aging Cell, 30:e12784. doi: 10.1111/acel.12784, 2018. - Veratridine-sensitive Na+ channels regulate human sperm fertilization capacity.
Candenas L Pinto FM Cejudo Román A González-Ravina C Fernández-Sánchez M Pérez-Hernández Irazusta J Subirán N
Life Sci, 196:48-55, 2018. - Cumulus cell transcriptome profiling is not predictive of live birth after in vitro fertilization: a paired analysis of euploid sibling blastocysts.
Green KA Franasiak JM Werner MD Tao X Landis JN Scott RT Treff NR
Fertil Steril, 109(3):460-466, 2018. - The Status of Genetic Screening in Recurrent Pregnancy Loss.
Kaser DJ
Obstet Gynecol Clin North Am, 45(1):143-154. doi: 10.1016/j.ogc.2017.10.007, 2018. - Validation of a targeted next generation sequencing-based comprehensive chromosomescreening platform for detection of triploidy in human blastocysts.
Marin D Zimmerman R Tao X Zhan Y Scott RT Treff NR
Reprod Biomed Online, 36(4):388-395, 2018. - Risk of pelvic inflammatory disease after intrauterine insemination: a systematic review.
Matorras R Rubio K Iglesias M Vara I Expósito A.
Hum Reprod, 36(2):164-171. doi: 10.1016/j.rbmo.2017.11.002, 2018, - Unexpected repeat immature oocyte response after IVF stimulation: a case report.
Mishra V Chirumamilla L
Gynecol Endocrinol, 34(2):100-102. doi: 10.1080/09513590.2017.1369514, 2018. - The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology.
Moreno I Cicinelli E Garcia-Grau I Gonzalez M Bau D Vilella F Ziegler D Resta L Valbuena D Simón C
Am J Obstet Gynecol, 218(6):602-602, 2018. - Three-Dimensional Angiogenic Evaluation of the Effect of Mifepristone in early gestation: pilot study
Pellicer-Iborra B Herraiz S Morales A Martínez S Garrido N Pellicer A
Gynecol Obstet, 7:90932,1000451, 2018. - NGS Analysis of Human Embryo Culture Media Reveals miRNAs of Extra Embryonic Origin.
Sanchez-Ribas I Díaz-Gimeno P Quiñonero A Ojeda M Larreategui Z Ballesteros A Domínguez F
Reprod Sci, NA:NA-NA, 2018. - Origin and composition of cell-free DNA in spent medium from human embryo culture during preimplantation development.
Vera-Rodriguez M Diez-Juan A Jimenez-Almazan J Martínez S Navarro R Peinado V Mercader A Meseguer M Blesa D Moreno I Valbuena D Rubio C Simón C
Hum Reprod, 33(4):745-756, 2018. - Validation of a targeted next generation sequencing-based comprehensive chromosomescreening platform for detection of triploidy in human blastocysts.
Marin D Zimmerman R Tao X Zhan Y Scott RT Treff NR
Reprod Biomed Online, pii: S1472-6483(17)30710-1. doi: 10.1016/j.rbmo.2017.12.015, 2018. - Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the IVF population
Juneau C Kraus E Werner MD Franasiak JM Morin SJ Patounakis G Molinaro T de Ziegler D Scott RT
Fertil Steril, 108: 284-288, 2017. - Detection of mosaicism at blastocyst stage with the use of high-resolution next-generation sequencing.
Munné S Wells D
Fertil Steril, 107:1085–1091, 2017. - Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the in vitro fertilization population.
Juneau C Kraus E Werner MD Franasiak JM Morin SJ Patounakis G Molinaro T De Ziegler D Scott RT
Fertil Steril, 108(2):284-288, 2017. - Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.
Zhang J Liu H Luo S Lu Z Chávez-Badiola A Liu Z Yang M Merhi Z Silber SJ Munné S Konstandinidis M Wells D Huang T
Reprod Biomed Online, 34:361-368, 2017. - Detailed investigation into the cytogenetic constitution and pregnancy outcome of replacing mosaic blastocysts detected with the use of high-resolution next-generation sequencing.
Munné S Blazek J Large M Martinez-Ortiz PA Nisson H Liu E Tarozzi N Borini A Becker A Zhang J Maxwell S Grifo J Babariya D Wells D Fragouli E
Fertil Steril, 108:62-71, 2017. - Karyomapping: a single centre experience from application of methodology to ongoing pregnancy and live-birth rates.
Ben-Nagi J Wells D Doye K Exeter H Drew E Alfarawati S Naja R Serhal P Loutradi K
Reprod Biomed Online, 35:264–271, 2017. - Mitochondrial DNA Quantification- the devil in the detail
Wells D Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munné S Fragouli E
Hum Reprod, 32:2150–2151, 2017. - Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts.
Fragouli E Alfarawati S Spath K Babariya D Tarozzi N Borini A Wells D
Hum Genet, 136: 805-819, 2017 - Type of chromosome abnormality affects embryo morphology dynamics.
Del Carmen Nogales M Bronet F Basile N Martínez EM Liñán A Rodrigo L Meseguer M
Fertil Steril, 107(1):229-235, 2017. - In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study.
Rubio C Bellver J Rodrigo L Castillón G Guillén A Vidal C Giles J Ferrando M Cabanillas S Remohí J Pellicer A Simón C
Fertil Steril. 2017 May;107(5):1122-1129. doi: 10.1016/j.fertnstert.2017.03.011. Epub 2017 Apr 19. - High relative deoxyribonucleic acid content of trophectoderm biopsy adversely affects pregnancy outcomes.
Neal SA Franasiak JM Forman EJ Werner MD Morin SJ Tao X Treff NR Scott RT
Fertil Steril, 107(3):731-736, 2017. - Crossing the germline: CRISPR-Cas9 and our responsibility as reproductive endocrinology and infertility physicians.
Kaser DJ Franasiak JM
J Assist Reprod Genet. 2018 Mar;35(3):399-402. doi: 10.1007/s10815-017-1075-3. Epub 2017 Oct 30. - Reply: Detecting mosaicism in trophectoderm biopsies.
Capalbo A Ubaldi F Rienzi L Scott RT Treff N
Hum Reprod. 2017 Mar 1;32(3):714-715. doi: 10.1093/humrep/dew347. No abstract available. - Abnormally fertilized oocytes can result in healthy live births: improved genetic technologies for preimplantation genetic testing can be used to rescue viable embryos in in vitro fertilization cycles
Capalbo A Treff N Cimadomo D Tao X Ferrero S Vaiarelli A Colamaria S Maggiulli R Orlando G Scarica C Scott RT Ubaldi FM Rienzi L
Fertil Steril. 2017 Sep 15. pii: S0015-0282(17)31699-0. doi: 10.1016/j.fertnstert.2017.08.004. [Epub ahead of print - Genomic instability during reprogramming by nuclear transfer is DNA replication dependent.
Chia G Agudo J Treff N Sauer MV Billing D Brown BD Baer R Egli D
Nat Cell Biol. 2017 Apr;19(4):282-291. doi: 10.1038/ncb3485. Epub 2017 Mar 6. - Spermatozoa with numerical chromosomal abnormalities are more prone to be retained by Annexin V-MACS columns.
Esbert M Godo A Soares SR Florensa M Amorós D Ballesteros A Vidal F
Andrology. 2017 Jun 14. doi: 10.1111/andr.12376. [Epub ahead of print] - Evaluation of comprehensive chromosome screening platforms for the detection of mosaic segmental aneuploidy.
Goodrich D Xing T Tao X Lonczak A Zhan Y Landis J Zimmerman R Scott RT Treff NR
J Assist Reprod Genet. 2017 Jun 2. doi: 10.1007/s10815-017-0924-4. [Epub ahead of print] - Continuing to deliver: the evidence base for pre-implantation genetic screening.
Griffin DK Fishel S Gordon T Yaron Y Grifo J Hourvitz A Rechitsky S Elson J Blazek J Fiorentino F Treff N Munne S Leong M Schmutzler A Vereczkey A Ghobara T Nánássy L Large M Hamamah S Anderson R Gianaroli L Wells D
BMJ. 2017 Feb 14;356:j752. doi: 10.1136/bmj.j752. No abstract available - Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the in vitro fertilization population.
Juneau C Kraus E Werner MD Franasiak JM Morin SJ Patounakis G Molinaro T De Ziegler D Scott RT
Fertil Steril. 2017 Jun 23. pii: S0015-0282(17)30421-1. doi: 10.1016/j.fertnstert.2017.05.038. [Epub ahead of print] - A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of EuploidEmbryos.
Labarta E Bosch E Mercader A Alamá P Mateu E Pellicer A
Biomed Res Int. Received 13 November 2016; Accepted 23 February 2017; Published 27 March 2017 - Corrigendum to "A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of Euploid Embryos".
Labarta E Bosch E Mercader A Alama P Mateu E Pellicer A
Biomed Res Int. 2017;2017:1718068. doi: 10.1155/2017/1718068. Epub 2017 Jul 13. - Comprehensive chromosome screening and gene expression analysis from the same biopsy in human preimplantation embryos.
Marin D Wang Y Tao X Scott RT Treff NR
Mol Hum Reprod. 2017 May 1;23(5):330-338. doi: 10.1093/molehr/gax014 - Preimplantation embryonic mosaicism: origin, consequences and the reliability of comprehensive chromosome screening.
Marin D Scott RT Treff NR
Curr Opin Obstet Gynecol. 2017 Jun;29(3):168-174. doi: 10.1097/GCO.0000000000000358. - Identification and characterization of Aurora Kinase B and C variants associated with maternal aneuploidy.
Nguyen AL Marin D Zhou A Gentilello AS Smoak EM Cao Z Fedick A Wang Y Taylor D Scott RT Xing J Treff N Schindler K
Mol Hum Reprod. 2017 Mar 25. doi: 10.1093/molehr/gax018. [Epub ahead of print] - In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study.
Rubio C Bellver J Rodrigo L Castillón G Guillén A Vidal C Giles J Ferrando M Cabanillas S Remohí J Pellicer A Simón C
Fertil Steril. 2017 May;107(5):1122-1129. doi: 10.1016/j.fertnstert.2017.03.011. Epub 2017 Apr 19. - Introduction: Subchromosomal abnormalities in preimplantation embryonic aneuploidy screening.
Scott RT
Fertil Steril. 2017 Jan;107(1):4-5. doi: 10.1016/j.fertnstert.2016.11.017 - Advances in Preimplantation Genetic Testing for Monogenic Disease and Aneuploidy.
Treff NR Zimmerman RS.
Annu Rev Genomics Hum Genet. 2017 May 12. doi: 10.1146/annurev-genom-091416-035508. [Epub ahead of print] - Assessment of embryo morphology and developmental dynamics by time-lapse microscopy: is there a relation to implantation and ploidy?
Zaninovic N Irani M Meseguer M
Fertil Steril. 2017 Nov;108(5):722-729. doi: 10.1016/j.fertnstert.2017.10.002. Review. - Detection of segmental aneuploidy and mosaicism in the human preimplantation embryo: technical considerations and limitations.
Treff N Franasiak JM
Fertil Steril, 107:27-31 - Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe. J Glob Oncol. 4, pp. 1 - 16. 28/06/2017.
Rashedi AS de Roo SF Ataman LM Edmonds ME Silva AA Scarella A Horbaczewska A Anazodo A Arvas A Ramalho de Carvalho B Sartorio C Beerendonk CCM Diaz-Garcia C
- Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy.
Ravichandran K Guzman L Escudero T Zheng X Colls P Jordan A Cohen J Wells D Munné S
Reprod Biomed Online, 33:550–559, 2016. - The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.
Sermon K Capalbo A Cohen J Coonen E De Rycke M De Vos A Delhanty J Fiorentino F Gleicher N Griesinger G Grifo J Handyside A Harper J Kokkali G Mastenbroek S Meldrum D Meseguer M Montag M Munné S Rienzi L Rubio C Scott KScott RT Simón C Swain J Treff N Ubaldi F Vassena R Vermeesch J Verpoest W Wells D Geraedts J
Mol Hum Reprod, 22:845–857, 2016. - Why do euploid embryos miscarry? A case-control study comparing the rate of aneuploidy within presumed euploid embryos that resulted in miscarriage or live birth using next-generation sequencing.
Maxwell SM Colls P Hodes-Wertz B McCulloh DH McCaffrey C Wells D Munné S Grifo J
Fertil Steril, 106:1414-1419, 2016. - Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.
Enciso M Sarasa J Xanthopoulou L Bristow S Bowles M Fragouli E Delhanty J Wells D
Hum Genet, 135:555–568, 2016. - Preimplantation genetic diagnosis: an overview and recent advances.
Ben-Nagi J Serhal P SenGupta S Doye K Wells D
Obstet Gynaecol, 18:99–106, 2016. - Current controversies in prenatal diagnosis 4: preimplantation genetic screening should be routinely offered to all preimplantation genetic diagnosis cases.
Harper J Wells D Simpson JL
Prenat Diagn, 36:25–28, 2016. - Mosaicism: “survival of the fittest” versus “no embryo left behind”.
Munné S Grifo J Wells D
Fertil Steril, 105:1146–1149, 2016. - Preimplantation genetic diagnosis for infertility.
Wells D Lewin J
In Textbook of Assisted Reproductive technologies, 5th Edition (Informa Healthcare, UK), p346-353. Edited by Gardner D, Weissman A, Howles C, Shoham Z. 2016. - Embryonic aneuploidy does not differ among genetic ancestry according to continental origin as determined by ancestry informative markers.
Franasiak JM Olcha M Shastri S Molinaro T Congdon H Treff NR Scott RT
HumReprod, 31(10):2391-5, 2016 - Kinetics of the early development of uniparental human haploid embryos.
Escribà MJ Escrich L Galiana Y Grau N Galán A Pellicer A
Fertil Steril, 105(5):1360-1368, 2016. - Aneuploidy screening by array comparative genomic hybridization improves success rates of in vitro fertilization: A multicenter Indian study.
Kotdawala A Patel D Herrero J Khajuria R Mahajan N Banker M
J Hum Reprod Sci, 9(4):223-229, 2016. - The challenge of embryonic mosaicism in preimplantation genetic screening.
Scott RT Galliano D
Fertil Steril; 105 (5): 1150-1152, 2016 - Técnicas invasivas y no invasivas en el diagnóstico de embriones humanos.
Calomarde C Carmona L Guerra I Gutiérrez D Santana A Domingo J
Rev Iberoam Fert Rep Hum, 33: 67-72, 2016. - Automatic time-lapse instrument is superior to single-point morphology observation for selecting viable embryos: retrospective study in oocyte donation.
Aparicio-Ruiz B Basile N Basile N Pérez Albalá S Bronet F Remohí J Meseguer M
Fertil Steril, 106:1379-85, 2016. - Embryonic aneuploidy does not differ amongst major ethnicities as determined by genotyping.
Franasiak JM Olcha M Treff N Scott RT
Hum Reprod 31:2391-5, 2016. - Challenges facing contemporary preimplantation genetic screening.
Juneau C Franasiak JM Treff N
Curr Opin Obstet Gynecol 28:151-7, 2016. - Preimplantation genetic screening - what a wonderful world it would be!
García-Velasco JA Fauser BC
Reprod Biomed Online. 32:337-8. 2016. - Pathophysiologic processes have an impact ot the plasma metabolomics signature of endometriosis patients.
Vicente-Muñoz S Morcillo I Puchades-Carrasco L Payá V Pellicer A Pineda-Lucena A
Fertil Steril, 106 (7): 1733-1741. E1, 2016. - A randomized and blinded comparison of qpcr and NGS based detection of aneuploidy in a cell line mixture model of blastocyst biopsy mosaicism.
Goodrich D Tao X Bohrer C Lonczak A Xing T Zimmerman R Zhan Y Scott RT Treff NR
Human Reprod, 30(2);276-83, 2015. - SNP array-based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts.
Treff NR Thompson K Rafizadeh M Chow M Morrison L Tao X Garnsey H Reda CV Metzgar TL Neal S Jalas C Scott RT Forman E
J Assist Reprod Genet, 33:1115-9, 2016. - Next Generation Sequencing Based Comprehensive Chromosome Screening in Mouse Polar Bodies, Oocytes, and Embryos.
Treff NR Krisher R Tao X Garnsey H Bohrer C Silva E Landis J Taylor D Scott RT Woodruff TK Duncan FE
Biol Reprod, 94:76, 2016. - Development and validation of concurrent preimplantation genetic diagnosis for single gene disorders and comprehensive chromosomal aneuploidy screening without whole-genome amplification.
Zimmerman RS Jalas C Tao X Fedick AM Kim J Pepe RJ Northrop LE Scott RT Treff NR
Fertil Steril, 105:286-94, 2016. - 24-chromosome PCR for aneuploidy screening.
Werner MD Scott RT
Curr Opin Obstet Gynecol. 2015. - Karyomapping allows preimplantation genetic diagnosis of a de-novo deletion undetectable using conventional PGD technology.
Giménez C Sarasa J Arjona C Vilamajó E Martínez-Pasarell O Wheeler K Valls G Garcia-Guixé E Wells D
Reprod Biomed Online, 31:770–775, 2015. - Live births following Karyomapping of human blastocysts: experience from clinical application of the method.
Konstantinidis M Prates R Goodall N Fischer J Tecson V Lemma T Chua B Jordan A Armenti E Wells D Munné S
Reprod Biomed Online, 31:394–403, 2015. - Deep impact: sequencing embryo biopsy specimens at increasing depth.
Spath K Wells D
Reprod Biomed Online, 31:1–3, 2015. - Karyomapping - a comprehensive means of simultaneous monogenic and cytogenetic PGD: comparison with standard approaches in real time for Marfan syndrome.
Thornhill AR Handyside AH Ottolini C Natesan SA Taylor J Sage K Harton G Cliffe K Affara N Konstantinidis M Wells D Griffin DK
J Assist Reprod Genet, 32:347–356, 2015. - Routine use of next-generation sequencing for preimplantation genetic diagnosis of blastomeres obtained from embryos on day 3 in fresh in~vitro fertilization cycles.
?ukaszuk K Pukszta S Wells D Cybulska C Liss J P?óciennik ? Kuczy?ski W Zabielska J
Fertil Steril, 103:1031–1036, 2015. - Comprehensive carrier genetic test using next-generation deoxyribonucleic acid sequencing in infertile couples wishing to conceive through assisted reproductive technology
Martin J Asan Y Alberola T Rodríguez-Iglesias B Jiménez-Almazán J Li Q Du H Alama P Ruiz A Bosch E Garrido N Simón C
Fertil Steril, 104(5):1286-93, 2015. - The use of morphokinetics as a predictor of implantation: a multicentric study to define and validate an algorithm for embryo selection.
Basile N Vime P Florensa M Aparicio-Ruiz B García-Velasco JA Remohí J Meseguer M
Hum Reprod, 30(2):276-83, 2015. - Systematic review on clinical outcomes following selection of human preimplantation embryos with time-lapse monitoring.
Freour T Basile N Barriere P Meseguer M
Hum Reprod Update, 21(1):153-4, 2015 - Endometrial Microbiome at the Time of Embryo Transfer: Next Generation Sequencing of the 16s Ribosomal Subunit.
Franasiak JM Werner MD Juneau C Tao X Landis J Zhan Y Treff N Scott RT
J Assist Reprod Genet 33:129-36, 2015. - Discordant embryonic aneuploidy testing and prenatal ultrasonography prompting androgen insensitivity syndrome diagnosis.
Franasiak JM Yao X Ashkindaze E Rosen T Scott RT
Obstet Gynecol 125:383-6, 2015. - Comprehensive chromosome screening improves embryo selection: a meta-analysis.
Dahdouh EM Balayla J García-Velasco JA
Fertil Steril. 104:1503-12, 2015. - Preimplantation genetic screening using comprehensive chromosome screening: evidence and remaining challenges.
Dahdouh EM Balayla J García-Velasco JA
Hum Reprod. 30:1515-6, 2015. - The time to prevent mendelian genetic diseases from donated or own gametes has come.
Garrido N Bosch E Alamá P Ruiz A
Fertil Steril, 104:833-835, 2015. - Diagnosis of human preimplantation embryo viability
Gardner D Meseguer M Rubio C Treff N
Hum Reprod Update, 21:727-747, 2015. - The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening.
Franasiak JM Forman EJ Hong KH Werner MD Upham KM Treff NR
Fertil Steril 2014;101(3):656–663.e1. - Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform.
Konstantinidis M Alfarawati S Hurd D Paolucci M Shovelton J Fragouli E Wells D
Fertil Steril, 102:1385–1392, 2014. - Live birth after PGD with confirmation by a comprehensive approach (karyomapping) for simultaneous detection of monogenic and chromosomal disorders.
Natesan SA Handyside AH Thornhill AR Ottolini CS Sage K Summers MC Konstantinidis M Wells D Griffin DK
Reprod Biomed Online, 29:600–605, 2014. - Human embryonic aneuploidy.
Fragouli E Wells D
Encyclopedia of Life Sciences, Online, 2014. - Clinical utilization of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation.
Wells D Kaur K Grifo J Glassner M Taylor JC Fragouli E Munné S
J Med Genet, 51:553–562, 2014. - Telomere length and aneuploidy: clinical and biological insights into human preimplantation embryos.
Simpson JL Wells D
Reprod Biomed Online, 28:531–532, 2014. - Next-generation sequencing: the dawn of a new era for preimplantation genetic diagnostics.
Wells D
Fertil Steril, 101:1250–1251, 2014. - Role of statins in PCOS management
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Chapter 11, pp 181-203. Editor: Lubna Pal. Springer, 2014. - Live birth after embryo transfer in an unresponsive thin endometrium.
Cruz F Bellver J
Gynecol Endocrinol. 2014 Jul;30(7):481-4. - Embryo aneuploidy screening with CGH arrays in the absence of implantation.
García-Herrero S García-Herrero S Rodrigo L Mateu E Peinado V Milán M Campos-Galindo I Vera M Mercader A Bronet F Requena A Simón C Rubio C
Médecine de la Reproduction, Gynécologie Endocrinologie, 16:112-119, 2014. - Increasing the probability of selecting chromosomally normal embryos by time-lapse morphokinetics analysis.
Basile N Nogales MC Bronet F Florensa M Riqueiros M Rodrigo L García-Velasco JA Meseguer M
Fertil Steril, 101:699-704, 2014. - Increasing the probability of selecting chromosomally normal embryos by time-lapse morphokinetic analysis.
Basile N Bronet F Nogales MC Martínez E Ariza M Agudo Garcillán D Florensa M Riqueros M Meseguer M
Fertil Steril 101(3):699-704, 2014. - Embryonic aneuploidy: overcoming molecular genetics challenges improves outcomes and changes practice patterns.
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Trends Mol Med 20:499-508, 2014. - Clinical genetic testing for male factor infertility: current applications and future directions.
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Andrology, 2(3), 339-50, 2014 - Embryo biopsy for aneuploidy detection in the general infertility population.
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Seminars of Reproductive Medicine, vol 31, 2014. Ed. V Baker. New York, NY: Thieme Medical Publishers. - Comparison of array comparative genomic hybridization and quantitative real-time PCR-based aneuploidy screening of blastocyst biopsies.
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Eur J Hum Genet, 23:901-6, 2014 - Polar body based aneuploidy screening is poorly predictive of embryo ploidy and reproductive potential.
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J Assist Reprod Genet, 31:1221-6, 2014. - Improved sensitivity to detect recombination using qPCR for Dyskeratosis Congenita PGD.
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JARG, 31:1227-30, 2014 - Obstetrical and neonatal outcomes from the BEST Trial: Single embryo transfer with aneuploidy screening improves outcomes after in vitro fertilization without compromising delivery rates.
Forman EJ Hong KH Franasiak JM Scott RT
Am J Obstet Gynecol, 210:157, 2014. - Uniparental disomy in the human blastocyst is exceedingly rare.
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Fertil Steril, 101: 232 -236, 2014. - The ethical implications of preimplantation genetic diagnosis.
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Clin Chem, 60:25-8, 2014. - To preserve or not to preserve: How difficult is the decision about fertility preservation?
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Cancer. 2013 Nov 15;119(22):4044-50. - Effects of simvastatin on retinoic acid system in primary human endometrial stromal cells and in a chimeric model of human endometriosis.
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J Clin Endocrinol Metabol, 2013. - Treatment of Luteal Phase Defects in Assisted Reproduction.
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Curr Drug Targets. Jul; 14(8):832-42, 2013. - Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials.
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Fertil Steril, 99(5):1400-7, 2013 - Metabolomic profiling of oocytes and embryos using spectroscopy: potential clinical use and pitfalls.
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In: D. Gardner, D. Sakkas, E. Seli, D. Wells eds. Emerging technologies for the assessment and diagnosis of gametes and embryos. Springer/Humana Press, Berlin, Germany, pp 275-280, 2013. - The origin and impact of embryonic aneuploidy.
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Hum Genet, 132:1001–1013, 2013. - Questions about the accuracy of polar body analysis for preimplantation genetic screening.
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Hum Reprod, 28:1731–1732, 2013. - High-density SNP arrays and next generation sequencing for pre-implantation genetic diagnosis.
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Biology and Pathology of the Oocyte, Role in Fertility and Reproductive Medicine (Cambridge University Press), p346-352. Edited by Eichenlaub-Ritter U, Gosden R, Trounson A. 2013. - Preimplantation genetic screening.
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The Textbook of Clinical Embryology (Cambridge University Press, UK). p346-356. Edited by Coward K. and Wells D. 2013. - Obstetric and neonatal outcomes from the BEST Trial: Single embryo transfer with aneuploidy screening improves outcomes after IVF without compromising delivery rates.
Forman EJ Hong KH Franasiak JM Scott RT
Am J Obstet Gynecol, 210:157.e1-6, 2013. - Additive effect of factors related to assisted conception on the reduction of maternal serum pregnancy-associated plasma protein A concentrations and the increased false-positive rates in first-trimes
Bellver J Casanova C Garrido N Lara C Remohí J Pellicer A Serra V
Fertil Steril, 100:1314-1320.e3, 2013. - False positive rate of an arrayCGH platform for single-cell preimplantation genetic screening and subsequent clinical application on day-3.
Mir P Rodrigo L Mercader A Buendía P Mateu E Milán-Sánchez M Peinado V Pellicer A Remohí J Simón C Rubio C
J Assist Reprod Genet, 30 (1); 143-9, 2013. - Selecting the optimal time to perform biopsy for preimplantation genetics
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Fertil Steril, 100: 608-614, 2013. - Incidental identification of balanced translocation carrier patients through comprehensive chromosome screening of IVF-derived blastocysts.
Treff NR Forman EJ Katz-Jaffe MG Schoolcraft WB Levy B Scott RT
J Assist Reprod Genet, 30:787-91, 2013. - Next-generation sequencing for preimplantation genetic diagnosis. Letter to the Editor.
Treff NR Forman EJ Scott RT
Fertil Steril, 99:e17-18, 2013 - Evaluation of targeted next-generation sequencing based preimplantation genetic diagnosis of monogenic disease.
Treff NR Fedick A Tao X Devkota B Taylor D Scott RT
Fertil Steril, 99:1377-1384, 2013. - Four-hour quantitative real-time polymerase chain reaction– based comprehensive chromosome screening and accumulating evidence of accuracy, safety predictive values and clinical efficacy.
Treff NR Scott RT
Fertil Steril, 99: 1049-1053, 2013. - Embryos whose polar bodies contain isolated reciprocal chromosome aneuploidy are almost always euploid.
Forman EJ Treff NR Stevens JM Garnsey HM Katz-Jaffe MG Scott RT Schoolcraft WB
Hum Reprod, 28:502-8, 2013. - Sperm DNA fragmentation index does not correlate with the sperm or embryo aneuploidy rate in recurrente miscarriage or implantation failure patients.
Bronet F Martínez E Gaytan M Liñán A Cernuda D Ariza M Nogales M Pacheco A San celestino M García-Velasco JA
Hum Reprod 27: 1922-9, 2012 - Characteristics of chromosomal abnormalities diagnosed after spontaneous abortions in an infertile population.
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J Assist Reprod Genet. May 2012. J Assist Reprod Genet. August 2012; 29 (8); 817-20. - Successful Live Birth following Preimplantation Genetic Diagnosis for Phenylketonuria in Day 3 Embryos by Specific Mutation Analysis and Elective Single Embryo Transfer.
Lavery S Abdo D JIMD Reports Kotrotsou M Trew G Konstantinidis M Wells D
JIMD Reports, 7:49–54, 2012. - Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLC?) from an infertile man by use of minisequencing of individual sperm and expression in somatic
Kashir J Konstantinidis M Jones C Heindryckx B Sutter P De Parrington J Wells D Coward K
Fertil Steril, 98:423–431, 2012. - Alteration of gene expression in human cumulus cells as a potential indicator of oocyte aneuploidy.
Fragouli E Wells D Iager AE Kayisli UA Patrizio P
Hum Reprod, 27:2559–2568, 2012. - Aneuploidy Screening for Embryo Selection.
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Semin Reprod Med, 30:289–301, 2012. - Transcriptomic analysis of follicular cells provides information on the chromosomal status and competence of unfertilized oocytes.
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Expert Rev Mol Diagn, 12:1–4, 2012. - Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes.
Munné S Held KR Magli CM Ata B Wells D Fragouli E Baukloh V Fischer R Gianaroli L
Fertil Steril, 97:935–942, 2012. - Preimplantation genetic diagnosis (PGD), preimplantation genetic screening (PGS) and the transfer of in vitro fertilized embryos.
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Bronet F Martínez E Gaytán M Liñán A Cernuda D Ariza M Nogales M Pacheco A San Celestino M García-Velasco JA
Hum Reprod, 27:1922-29, 2012 - Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS.
Castillo JC García-Velasco JA Humaidan P
J Assist Reprod Genet. 29:249-53, 2012. - Hepatitis B virus in human oocytes and embryos
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Hum Reprod, 27:1227-1228, 2012. - Consistent and predictable delivery rates after oocyte vitrification: an observationallongitudinal cohort multicentric study.
Muñoz E Bosch E Fernandez I Portela S Ortiz G Remohí J Pellicer A
Hum Reprod, 13(3):409-16; 2012. - Chromosomal abnormalities in embryos from couples with a previous aneuploid miscarriage.
Al-Asmar N Peinado V Vera M Remohí J Pellicer A Simón C Hassold T Rubio C
Fertil Steril, 98(1);145-50, 2012. - Comprehensive chromosome screening and embryo selection: moving toward single euploid blastocyst transfer.
Forman EJ Hong KH Treff NR Scott RT
Semin Reprod Med, 30:236-42, 2012. - Methods for comprehensive chromosome screening of oocytes and embryos: capabilities, limitations, and evidence of validity.
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J Assist Reprod Genet, 29:381-90, 2012 - Delivery of a chromosomally normal child from an oocyte with reciprocal aneuploid polar bodies.
Scott RT Treff NR Stevens J Forman EJ Hong KH Katz-Jaffe MG Schoolcraft WB
J Assist Reprod Genet, 29:533-7, 2012. - Blastocyst preimplantation genetic diagnosis of a mitochondrial DNA disorder.
Treff NR Tao X Campos J Su J Ferry KM Levy B Scott RT
Fertil Steril, 98:1236-1240, 2012. - Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study.
Scott RT Ferry KM Su J Tao X Scott KL Treff NR
Fertil Steril, 97:870-875, 2012. - Development and validation of an accurate quantitative real-time polymerase chain reaction – based assay for human blastocyst comprehensive chromosomal aneuploidy screening. Seminal Contribution.
Treff NR Tao X Ferry KM Su J Taylor D Scott RT
Fertil Steril, 97:819-824, 2012. - Single embryo transfer with comprehensive chromosome screening results in improved ongoing pregnancy rates and decreased miscarriage rates.
Forman EJ Tao X Ferry KM Taylor D Treff NR Scott RT
Human Reproduction, 27:1217- 22, 2012. - Self-correction in tripronucleated human embryos.
Grau N Escrich L Martín J Rubio C Pellicer A Escribà MJ
Fertil Steril, 96(4):951-6, 2011. - A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC?) leads to male infertility.
Kashir J Konstantinidis M Jones C Lemmon B Lee HC Hamer R Heindryckx B Deane CM De Sutter P Fissore RA Parrington J Wells D Coward K
Hum Reprod, 27:222–231, 2011. - The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy.
Fragouli E Alfarawati S Goodall N Sanchez-Garcia JF Colls P Wells D
Mol Hum Reprod, 17:286–295, 2011. - First births after preimplantation genetic diagnosis of structural chromosome abnormalities using comparative genomic hybridization and microarray analysis.
Alfarawati S Fragouli E Colls P Wells D
Hum Reprod, 26:1560–1574, 2011. - Chromosome Abnormalities in the Human Oocyte.
Fragouli E Wells D Delhanty J
Cytogenet Genome Res, 133:107–118, 2011 - PGD and aneuploidy screening for 24 chromosomes: advantages and disadvantages of competing platforms.
Bisignano A Wells D Harton G Munné S
Reprod Biomed Online, 23:677–685, 2011. - Aneuploidy in the Human Blastocyst
Fragouli E Wells D
Cytogenet Genome Res, 133:149–159, 2011. - Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos.
Gutiérrez-Mateo C Colls P Sánchez-Garcia J Escudero T Prates R Ketterson K Wells D Munné S
Fertil Steril, 95:953–958, 2011. - Therapeutic treatments of mtDNA diseases at the earliest stages of human development.
Chiaratti MR Meirelles FV Wells D Poulton J
Mitochondrion, 11:820–828, 2011. - Cumulative live-birth rates per total number of embryos needed to reach newborn in consecutive in vitro fertilization (IVF) cycles: a new approach to measuring the likelihood of IVF success.
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Fertil Steril, 96:40-46, 2011. - Effect of sperm DNA fragmentation on pregnancy outcome depends on oocyte quality
Meseguer M Santiso R Garrido N García-Herrero S Remohí J Fernandez JL
Fertil Steril, 95:124-128, 2011. - Fertility after age 45: From natural conception to assisted reproductive technology and beyond.
Forman EJ Treff NR Scott RT
Maturitas, 70:216-221, 2011. - Telomere DNA deficiency is associated with development of human embryonic aneuploidy.
Treff NR Su J Taylor D Scott RT
PLoS Genetics, 7: e1002161, 2011 - SNP Microarray Based Concurrent Screening of 24 Chromosome Aneuploidy and Unbalanced Translocations in Preimplantation Human Embryos.
Treff NR Northrop L Kasabwala K Su J Levy B Scott RT
Fertil Steril, 95:1606-1612, 2011. - Surgical management of tubal disease and infertility
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Obstetrics, Gynaecology and Reproductive Medicine, Vol 19, 2010. - Blood group and ovarian hyperstimulation syndrome.
Bellver J Ferrando M Garrido N Pellicer A
Fertil Steril, 93:270-1, 2010. - Accurate single cell 24 chromosome aneuploidy screening using whole genome amplification and single nucleotide polymorphism microarrays.
Treff NR Su J Tao X Levy B Scott RT
Fertil Steril, 94: 2017-2021, 2010. - GnRH agonist administration at the time of implantation does not improve pregnancy outcome in intrauterine insemination cycles: a randomized controlled tria
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Fertil Steril 94(3):1065-71, 2010. - Severe Refractory Hidradenitis Suppurativa in HIV-Positive Patient Successfully Treated with Infliximab.
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Archives of Dermatology. Dec; 146(12):1343-5.2010 - Impacto de un complejo de antioxidantes sobre la fragmentación del ADN espermático en varones infértiles
Balmori C Areces C Pacheco A San Celestino M García-Velasco JA
Rev Int Androl 8: 107-13, 2010 - Cytogenetic analysis of human blastocysts with the use of FISH, CGH and aCGH: scientific data and technical evaluation.
Fragouli E Alfarawati S Daphnis D Goodall N Mania A Griffiths T Gordon T Wells D
Hum Reprod, 26:480–490, 2010. - Transmission of Mitochondrial DNA Diseases and Ways to Prevent Them.
Poulton J Chiaratti MR Meirelles FV Kennedy S Wells D Holt IJ
PLoS Genet, 6, 2010. - Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes.
Munné S Wells D Cohen J
Fertil Steril, 94:408–430, 2010. - Microarrays and CGH for PGD of chromosome abnormalities and gene defects.
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Journal of Reproductive Medicine and Endocrinology, 7:236-239, 2010 - Embryo aneuploidy and the role of morphological and genetic screening.
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Reprod Biomed Online, 21:274–277, 2010. - Transcriptomic profiling of human oocytes: association of meiotic aneuploidy and altered oocyte gene expression.
Fragouli E Bianchi V Patrizio P Obradors A Huang Z Borini A Delhanty J Wells D
Mol Hum Reprod, 16:570–582, 2010. - Improved detection of aneuploid blastocysts using a new 12-chromosome FISH test.
Munné S Fragouli E Colls P Katz-Jaffe MG Schoolcraft WB Wells D
Reprod Biomed Online, 20:92–97, 2010. - Y chromosome microdeletions, sperm DNA fragmentation and sperm oxidative stress as causes of recurrent spontaneous abortion of unknown etiology.
Bellver J Meseguer M Muriel L Garcia-Herrero S Barreto MAM Garda AL Remohí J Pellicer A Garrido N
Hum Reprod, 25:1713-1721, 2010. - Improving FISH diagnosis for preimplantation genetic aneploidy screening
Mir P Rodrigo L Mateu E Milán M Mercader A Buendía P Delgado A Pellicer A Remohí J Rubio C
Human Reprod, 25(7); 1812-7, 2010. - Aneploidies in embryos and spermatozoa from patients with Y chromosome microdelections.
Mateu E Rodrigo L Martínez MC Peinedo V Delagado A MIr P Simón C Remohí J
Reprod Biomed Online, 21(5); 649-57, 2010. - Single Cell Whole Genome Amplification Technique Impacts the Accuracy of SNP Microarray Based Genotyping and Copy Number Analyses.
Treff NR Su J Tao X Northrop L Scott RT
Mol Hum Repro, 17: 335–343, 2010. - SNP microarray based 24 chromosome aneuploidy screening demonstrates that cleavage stage FISH poorly predicts aneuploidy in embryos that develop to morphologically normal blastocysts.
Northrop L Treff NR Levy B Scott RT
Mol Hum Repro, 16:590-600, 2010. - SNP microarray based 24 chromosome aneuploidy screening is significantly more consistent than FISH.
Treff NR Levy B Su J Northrop L Tao X Scott RT
Mol Hum Repro, 16:583-9, 2010. - Assessing the reproductive competence of individual embryos: a proposal for the validation of new "-omics" technologies.
Scott RT Treff NR
Fertil Steril, 94:791-794, 2010. - Robust embryo identification using polar body single nucleotide polymorphism microarray based DNA fingerprinting.
Treff NR Su J Kasabwala N Tao X Miller KA Scott RT
Fertil Steril, 93: 2453-2455, 2010. - The p53 codon 72 single nucleotide polymorphism lacks a significant effect on implantation rate in fresh in vitro fertilization cycles: an analysis of 1,056 patients.
Patounakis G Treff N Tao X Lonczak A Scott RT Frattarelli JL
Fertil Steril, 92:1290-6. 2009. - Comparative genomic hybridization of oocytes and first polar bodies from young donors.
Fragouli E Escalona A Gutiérrez-Mateo C Tormasi S Alfarawati S Sepulveda S Wells D Munné S
Reprod Biomed Online, 19:228–237, 2009. - Vitrification of preimplantation genetically diagnosed human blastocysts and its contribution to the cumulative ongoing pregnancy rate per cycle by using a closed device
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Fertil Steril, 89(4):840-6, 2008 - Técnica de B-Lynch en el control de la hemorragia posparto Progresos de Obstetricia
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Ginecología Volumen 51,(9), 513-519, 2008. - Birth of a healthy boy after a double factor PGD in a couple carrying a genetic disease and at risk for aneuploidy.
Obradors A Fernandez E Oliver-Bonet M Rius M de la Fuente A Wells D Benet J Navarro J
Hum Reprod, 23:1949–1956, 2008. - Evaluation of embryo quality by Metabolomics: A new strategy to aid single embryo transfer.
Sakkas D Morita H Yamashita N Kato LO Botros L Roos P Seli E
J Mammal Ova Res. 25:26-31, 2008. - Soluble vascular endothelial-cadherin levels correlate with clinical and biological aspects of severe ovarian hyperstimulation syndrome.
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Hum Reprod. 23:662-7, 2008. - Artículo de revisión "Diagnóstico por imagen”
Puente J Grañeras A Requena A
Cuadernos de Medicina Reproductiva, 13( 2) : 37-51, 2007. - Sperm selection by swim-up in terms of deoxyribonucleic acid fragmentation as measured by the sperm chromatin dispersion test is altered in heavy smokers.
Viloria T Garrido N Fernández JL Remohí J Pellicer A Meseguer M
Fertil Steril, 88:523-525, 2007. - Single cell diagnosis using comparative genomic hybridization after preliminary DNA amplification still needs more tweaking: too many miscalls.
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Fertil Steril, 88:247–248, 2007. - J.Ultrastructure of preimplantation genetic diagnosis-derived human blastocysts grown in a coculture system after vitrification.
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Fertil Steril, 86(3):664-71, 2006 - Heteroparental blastocyst production from microsurgically corrected tripronucleated human embryos.
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Fertil Steril, 86(6):1601-7, 2006. - Prenatal management of placental chorioangioma: value of the middle cerebral artery peak systolic velocity.
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Fetal Diagn Ther, 21(6):489-93, 2006. - Use of Real-Time Polymerase Chain Reaction to Measure Gene Expression in Single Cells.
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In Single Cell Diagnostics: Methods and Protocols (Humana Press, USA), p125-134. Edited by Thornhill, A. 2006. - A successful strategy for Preimplantation Genetic Diagnosis of betathalassemia and simultaneous detection of Down's syndrome using multiplex fluorescent PCR.
Piyamongkol W Vutyavanich T Piyamongkol S Wells D Kunaviktikul C Tongsong T Chaovisitsaree S Saetung R Sanguansermsri T
J Med Assoc Thai, 89:918-27, 2006. - Estudio comparativo de dos medios de cultivo HTF e ISM-1: implicaciones en el fenotipo embrionario y resultados clínicos.
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Revista Iberoamericana de Fertilidad y Reproducción Humana, 23: 375-382, 2006. - Etiologia, diagnostico y manejo del hidrops fetal: revision de 140 casos
Arbués J Galindo A Puente J Grañeras A De la Fuente P
Prog Obstet Ginecol 48:225-230, 2005. - Isolated unilateral pulmonary agenesis. Early prenatal diagnosis and long-term follow up.
Arbués J Galindo A Rasero M Orbea C Puente J De la Fuente P
J Ultrasound Med, 24: 865-8, 2005. - The singleton, term gestation, and live birth rate per cycle initiated: a 1-year experience in in vitro fertilization cycles with native and donated oocytes.
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Fertil Steril, 83:1404-9, 2005. - Near Speed-of-Light On-Chip Interconnects Using Pulsed Current-Mode Signaling.
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2005 Symposium on VLSI Circuits, 108-11. 2005. - Association of abnormal morphology and altered gene expression in human preimplantation embryos.
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Fertil Steril, 84:343–355, 2005. - Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation development.
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Hum Reprod, 20:1339–1348, 2005. - Reliability of comparative genomic hybridization to detect chromosome abnormalities in first polar bodies and metaphase II oocytes.
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Hum Reprod, 19:2118–2125, 2004. - Advances in preimplantation genetic diagnosis.
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Eur J Obstet Gynecol Reprod Biol, 115:S97-S101, 2004. - Rabbit and pig ear skin sample cryobanking: effects of storage time and temperature of the whole ear extirpated immediately after death.
Silvestre MA Saeed AM Cervera RP Escribà MJ García-Ximénez F
Theriogenology, 59(5-6):1469-77, 2003. - Detailed investigation of factors influencing amplification efficiency and allele drop-out in single cell PCR: implications for preimplantation genetic diagnosis.
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Mol Hum Reprod, 9:411–420, 2003. - Single-cell sequencing and mini-sequencing for preimplantation genetic diagnosis.
Bermudez MG Piyamongkol W Tomaz S Dudman E Sherlock JK Wells D
Prenat Diagn, 23:669–677, 2003. - Viable offspring derived from cryopreserved haploid rabbit parthenotes
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Theriogenology, 57(4):1319-25, 2002 - New techniques on embryo manipulation.
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J Reprod Immunol, 55(1-2):149-61. Review, 2002 - Vitrification and rapid freezing of rabbit fetal tissues and skin samples from rabbits and pigs.
Silvestre MA Saeed AM Escribà MJ García-Ximénez F
Theriogenology, 58 (1):69-76, 2002. - Preimplantation genetic diagnosis: an alternative to prenatal diagnosis.
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Expert Rev Mol Diagn, 2:395–399, 2002. - First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy.
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Fertil Steril, 78:543–549, 2002. - Preimplantation genetic diagnosis for single gene disorders: experience with five single gene disorders.
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Prenat Diagn, 22:525–533, 2002. - Towards a comprehensive analysis of chromosomes and DNA sequences in human embryos.
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In Advances in Infertility Treatment (Monduzzi Editore, Italy), p459-473. Edited by Filicori M. 2002. - The "vanishing embryo" phenomenon in an oocyte donation programme.
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Fertil Steril. 77:542-7, 2002. - Comparison of the effect of two different handling media on rabbit zygote developmental ability
Escribà MJ Silvestre MA Saeed AM García-Ximénez F
Reprod Nutr Dev, 41(2):181-6, 2001. - Acrocentric chromosome disomy is increased in spermatozoa from fathers of Turner syndrome patients
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Hum Genet, 108:499-503, 2001 - Numerical chromosome abnormalities in the spermatozoa of the fathers of children with trisomy 21 of paternal origin: generalised tendency to meiotic non-disjunction.
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Hum Genet, 108:134-39, 2001. - Preimplantation genetic diagnostic protocols for alpha- and beta-thalassaemias using multiplex fluorescent PCR.
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Prenat Diagn, 21:753–759, 2001. - PGD protocols using multiplex fluorescent PCR.
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Reprod Biomed Online, 2:212–214, 2001. - A successful strategy for preimplantation genetic diagnosis of myotonic dystrophy using multiplex fluorescent PCR.
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Prenat Diagn, 21:223–232, 2001 - Genetic alterations in gastric cancers from British patients.
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Cancer Genet Cytogenet, 126:111–119, 2001. - Preimplantation genetic diagnosis: applications for molecular medicine.
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Trends Mol Med, 7:23–30, 2001 - Future developments in preimplantation genetic diagnosis.
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In Preimplantation Genetic Diagnosis (John Wiley & Sons, UK) p241-262. Edited by Harper J, Delhanty J, Handyside A. 2001. - Vitrification and rapid-freezing of cumulus cells from rabbits and pigs.
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Theriogenology, 54(9):1359-71, 2000. - Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization.
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Mol Hum Reprod, 6:1055–1062, 2000. - A successful strategy for preimplantation diagnosis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency.
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Prenat Diagn, 20:593–598, 2000. - Comparative Genomic Hybridization Reveals Extensive Variation Among Different MCF-7 Cell Stocks.
Jones C Payne J Wells D Delhanty JDA Lakhani SR Kortenkamp A
Cancer Genet Cytogenet, 117:153–158, 2000. - Deletion and duplication of the adenomatous polyposis coli gene resulting from an interchromosomal insertion involving 5 (q22q23.3) in the father.
Hastings RJ Svennevik EC Setterfield B Wells D Delhanty JDA Mackinnon H
J Med Genet, 37:141–145, 2000. - Positive outcome after preimplantation diagnosis of aneuploidy in human embryos.
Munne S Magli C Cohen J Morton P Sadowy S Gianaroli L Tucker M Marquez C Sable D Ferraretti AP Massey JB Scott RT
Human Reprod, 14:2191-9, 1999. - Strategies for preimplantation genetic diagnosis of single gene disorders by DNA amplification.
Wells D Sherlock JK
Prenat Diagn, 18:1389–1401, 1998. - Preimplantation genetic diagnosis of cancer: familial adenomatous polyposis coli (FAPC).
Ao A Wells D Handyside AH Winston RML Delhanty JDA
J Assist Reprod Genet, 15:140–144, 1998. - Genetic diagnosis before implantation.
Delhanty JDA Wells D Harper JC
BMJ, 315:828–829, 1997. - Detection of haemoglobinopathies and chromosome aneuploidy from minute DNA samples using multiplex PCR.
Sherlock J Cirigliano V Petrou M Wells D Adinolfi M
In Infertility and Assisted Reproductive Technology - From Research to Therapy (Monduzzi Editore, Italy) p203-211. Edited by Ambrosini A, Melis GB, Dalla Pria S, Dessole S. 1997. - APC gene mutation and DNA microsatellite instability in pancreatic cancers of UK origin.
See CG Sud R Wells D Bowles L Ding S Habib N Delhanty JDA
GI Cancer 2, 133-137, 1996. - Preimplantation genetic diagnosis of beta-thalassaemia.
El-Hashemite N Wells D Delhanty JDA
Lancet, 348:620–621, 1996. - Rapid detection of rare variants and common polymorphisms in the APC gene by PCR-SSCP for presymptomatic diagnosis and showing allele loss.
Gayther SA Sud R Wells D Tsioupra K Delhanty JD
J Med Genet, 32:568–571, 1995. - Correlation of loss of heterozygosity with cytogenetic analysis using g-banding and fluorescence in situ hybridization in aneuploid cultures from two human testicular germ-cell tumors.
Al-Jehani RMA Wells D Fox M Parrington JM
Cancer Genet Cytogenet, 85:26–36, 1995.
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Presentations from this area
- Florensa Bargalló M Cladellas Artola A Bellés Fernandez Jimenez Blasco M Herreros Cuesta J Huete Ferriz Garrido N Esbert Algam M Relationship between both euploidy and thawing survival rates and embryo quality, day of biopsy or hatching status in Preimplantation Genetic Testing cycles Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
ESHRE 2020
- Hernández-Vargas P Gadea B Lozoya V Legidos V Muñoz M The effect of endometriosis in the chromosomal status and developmental competence of cleavage-stage embryos. Differences with embryos in the blastocyst stage Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
- Riqueros M Correlation between 3 qualitative markers of ovarian function with embryo aneuploidy Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
- Rodriguez Valderrama F Palomino MC Pla Victori J Requena A Chromosomal abnormalities in males, but not chromosomal polymorphisms, affect the preterm delivery rate in ICSI+PGT cycles Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
- Delgado Mendive A Mercader A Escrich L Beltran B Tejera A Grau N Insua F Nohales M Mifsud M Euploidy and embryo quality with single step medium with or without renewal post assisted hatching (AH) in a PGT-A program using Embryoscope dishes Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
- Leaver M Kubikova N Tao X Jalas C Wells D O-270 A nobel long-range DNA sequencing approach improves the design of new protocols for preimplantation genetic testing of monogenic disease (PGT-M). Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
- Abdala A Elkhatib I Bayram A Arnanz A El-Damen A Lawrenz B Fatemi H De Munck N Influence of culture media on embryo developmental pattern and ploidy status: a sibling oocyte study Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
- Arnanz A De Munck N El Khatib I Bayram A El-Damen A Abdala A Melado L Lawrenz B Pacheco A Fatemi H Vitamin D (VitD) in follicular fluid (FF) correlates with the euploid status of the embryo in a VitD deficient Middle Eastern population Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
- Niag dos Santos Rocha M Freitas D Carvalho R Oliveira T Santos C Abreu T Teixeira C Almeida A Queiroz L Coelho G O-293 Evaluation of the relation between the value of mitochondrial DNA (MitoScore) and euploid embryo quality Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
- Markova D Kagan KO Hoopmann M Abele H Abecia E Fatemi H Lawrenz B Impact of Preimplantation Genetic Testing for Aneuploidies (PGT-A) on first trimester biochemical markers - PAPP-A (placenta associated plasma protein) and free ?-hCG (human chorionic gonadotropin) Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
- Tiegs A Tao X Whitehead Neal S Osman E Kim J Hanson B Seli E Patounakis G Gutmann JN Castelbaum AJ Scott RT O-084 A multi-center, prospective, blinded, non-selection study evaluating the predictive value (PV) of an aneuploid preimplantation genetic testing for aneuploidy (PGT-A) diagnosis and impact of biopsy Presented at the 67th Annual Meeting of the Society for Reproductive Investigation
SRI 2020
- Nelson SM La Marca A García Velasco JA Göthberg M Jonker DM Mannaerts B O-211 Impact of body weight on ovarian response after individualized or fixed follicle-stimulating hormone dosing in women undergoing ovarian stimulation for in vitro fertilization Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2019
- Corachán A Ferrero H Escrig J Monleón J Faus A Cervelló I Pellicer A Eects of Vitamin D in Human Uterine Leiomyoma Growth in a Xenograft Animal Model. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2019
- Gonzalez-Martin R Quiñonero A Pérez S Salsano S Domínguez F Acute DEHP Exposure in Endometrial Epithelial Cells Does Not Phenocopy the Alterations Described in Endometriosis. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
- Duan J Jiang Z Seli E Tian X Wang T Zhang M Evaluating mitochondrial stress response gene clpp-regulated dna methylome dynamics in female reproductive aging Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2018
- Kim G Morin SJ Patounakis G Juneau C Neal SA Abc trial: appraisal of body content. Frozen embryo cycles are not impacted by the negative effects of obesity seen in fresh cycles Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
- Tiegs W Tao X Landis J Rajchel J Bedard JL Seli E Wells D Fragouli E Scott RT Evaluation of sperm mitochondrial dna copy number as a predictor of in vitro fertilization/intracytoplasmic sperm injection (ivf/icsi) cycle outcomes in a large infertile population Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
- Costa-Borges N Spath K Nikitos E Ribustello L Miguel-Escalada I Rink K Kostaras K Psathas P Wells D Calderon G Cytoplasm replacement by spindle transfer demonstrates enhanced embryo development without compromising euploidy rates: pre-clinical study with donor oocytes Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Neal A Goodman LR Morin SJ Werner MD Gueye N Tiegs W Pirtea P Scott RT T-shaped uterine cavity morphology as assessed by three-dimensional ultrasound (3d us) is associated with lower sustained implantation rates and higher clinical loss rates following frozen embryo Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Nohales M Soler N Gonzalez-Picazo A Escriba M Vendrell X Bautista-Llacer R Tena R Pabon D Ploidy condition and developmental competence of unipronuclear embryos Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Dolitsky N Neal SA Olcha M Hong K Werner MD Morin SJ Tiegs W Sun L Scott RT Initial serum human chorionic gonadotropin levels predict live birth outcomes following frozen embryo transfer with and without preimplantation genetic testing for aneuploidy (pgt-a) Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Alegre L Del Gallego R Peura T Bori L Aparicio Ruiz B Adam A Coello A Castello D Meseguer M Embryologists team vs. Automated annotation software outcomes Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Layman L Feinberg E Hurst B Morin SJ Morris J Pisarka M Smith YR Price TM Academic pursuits in board certified reproductive endocrinologists Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Lara-Molina EE Franasiak JM Devesa-Peiro A Florensa M Martin M Lopez M Diaz-Gimeno P Pellicer A Ovarian vitamin d metabolism is conserved despite seasonal variability and follicular maturation Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Del Gallego R Alegre L Cnaani T Shnizer S Remohí J Meseguer M Clinical validation of a non-invasive embryo selection algorithm combining time-lapse morphokinetics and the oxidative status of spent embryo culture media. Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ESHRE 2018
- Liñán A Bayram A Arnanz A Elkhatib I Rubio C Rupali C Garrido N Fatemi H Lawrenz B Comparison of mitochondrial DNA content in euploid and aneuploid embryos at cleavage stage and blastocyst stage with NGS Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Castillo LM Buigues A Pellegrini L Rossi V Klinger F Pellicer A Herraiz S LH gonadoprotection against ovarian damage induced by alkytaing drugs in adult mouse ovaries. Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Devesa A Sebastian-Leon P Garcia-Garcia F Arnau V Pellicer A Diaz-Gimeno P Functional genomic meta-analysis identifies similarities between endometrial-related subfertilities Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Staicu FD Martinez-Soto JC Matas C Protein kinase A modulation by nitric oxide during human sperm capacitation Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Elkhatib I Lawrenz B Linan A Arnanz A Bayram A Fatemi H Comprehensive comparison of Trophectoderm (TE) and Inner cell mass (ICM) by Next Generation Sequencing (NGS) Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Labarta E Herraiz S De Los Santos MJ Marzal A Jose Escribá M Buigues A Pellicer A Autologous mitochondrial transfer (AugmentSM) as a complementary technique to ICSI to improve oocyte and embryo quality in IVF patients. A Randomized Pilot Study. Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
- Esbert M Garrido N Ballesteros A Giménez Sanz A Florensa M Predictors of positive sperm retrieval in azoospermic Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
- Labarta E Herraiz S De Los Santos MJ Marzal A Jose Escribá M Buigues A Pellicer A Autologous stem cell ovarian transplant to improve ovarian response and reproductive outcomes in poor responder patients Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
- Tao X Zhan Y Scott K Scott RT Seli E DNA methylation is associated with ploidy status, delayed blastulation, and patient age in human embryos Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2018
- Alegre L Garrido N Munoz M De los Santos M Remohí J Meseguer M Sperm selection with hyaluronic acid (PICSI) improves LBR in IVF treatments Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2017
- Bedard JL Jalas C Juneau CR Zimmerman RS Scott RT Sustained implantation rate is not impacted by increasing fragile X premutation allele size Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
- Colombo S Franasiak JM Kaser DJ Molinaro T Bergh PA Significance of endometrial lining decrease after progesterone start in synthetic frozen embryo transfer (FET) cycles Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
- Dougherty MP Morin SJ Doherty L Bohrer M Leary S Scott RT Goodman L Surgical management of complete uterine/vaginal septum with duplication of the cervix Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology