Pre-implantation Genetics

The “holy grail” of reproductive medicine is to discover a technology allowing identification of those embryos that have true reproductive potential as evidenced by implantation, normal obstetrical course, and delivery of a healthy infant. While it may seem counter-intuitive that a normally developing embryo cannot implant, the reality is that many factors limit reproductive competence of the embryo that do not impact these early morphologic markers. Chief amongst these are the meiotic and mitotic errors that lead to an imbalance in the number of chromosomes present in the embryo, termed embryonic aneuploidy.

Embryonic aneuploidy is a significant factor in limiting the efficiency of reproduction, even amongst young women. We have extensively studied and validated aneuploidy testing and shown it to be a beneficial tool when applied clinically. Studies continue to further investigate the causes of aneuploidy, better determine normality, and perhaps one day provide therapy.

Investigators working in this area

Dagan Wells, Ph.D.

Oxford Research Director

Oxford Basic Research Centre

Richard T Scott, M.D.,H.C.L.D.

Founding Partner IVIRMA Global

Elpida Fragouli, MSc,Ph.D.

Research Laboratory Director

Oxford Basic Research Centre

Jason Franasiak, MD, FACOG, HCLD/ALD (ABB)

Chief Medical Officer of IVIRMA America

George Patounakis, M.D., Ph.D.

Medical Director at RMA of Florida

Thomas Molinaro, M.D.

Reproductive Endocrinologist at RMA of New Jersey

Marie D. Werner, M.D.

Reproductive Endocrinologist at RMA of New Jersey

Antonio Pellicer_IVIRMA Roma_c

Antonio Pellicer , M.D., Ph.D.

Chief Executive Officer for IVIRMA Global

Carmina Vidal, M.D., Ph.D.

Gynecologist and Reproductive Medicine Specialist at IVI Valencia

David Agudo Garcillán, Ph.D.

Assistant Manager of the IVF Laboratory at the IVI Madrid

Diana Alecsandru, M.D., Ph.D.

Consultant Clinical Immunologist. Physician for Reproductive Immunology. Reproductive Immunology, Endocrinology and Infertility Unit.

María José Escribà, Ph.D.

Head investigator at IVI Valencia and FIVI-INCLIVA

Natalia Basile, Ph.D.

Embryologist at IVI Madrid

Manuel Fernández-Sánchez, M.D., Ph.D.

Director of IVI Sevilla

Laura Melado Vidales, M.D., Ph.D.

IVF specialist IVI Middle East

IVI Middle East

Manuel Muñoz, M.D., Ph.D.

Director of IVI Alicante

Marta Molla, B.Sc.

Laboratory Manager at IVI Murcia

Fernando Bronet, Ph.D.

Director of the IVF and PGD Laboratories at IVI Madrid

Irene Rubio Palacios, Ph.D.

Clinical Embryologist and Project Manager in Medical Affairs

Marcos Meseguer, Ph.D.

Scientific Supervisor and Senior Embryologist at the IVI Valencia IVF unit

José Remohí, M.D – Ph.D.

Founding Partner IVI-RMA Global

Emre Seli, M.D.

Chief Scientific Officer for IVIRMA Global

Human Fatemi, M.D., Ph.D.

Medical Director of the IVI Middle East

IVI Middle East

Scott Morin, M.D.

Reproductive Endocrinologist at RMA of Northern California

RMA Northen California

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Publications from this area

Presentations from this area

ASRM2020
Cozzolino M Garcia-Velasco JA Meseguer M Pellicer A Bellver J O-153 OBESE WOMEN PRESENT AN INCREASED RISK OF MISCARRIAGE AFTER EUPLOID EMBRYO TRANSFER Presented at 76th American Society of Reproductive Medicine Scientific Congress
Perez-Albala S Aparicio-Ruiz B Bori L Remohi JA Viloria T Meseguer M P-99 EMBRYO AUTOMATIC DIAGNOSTIC TEST; BLASTULATION, ANEUPLOIDY AND IMPLANTATION RATE PREDICTION Presented at 76th American Society of Reproductive Medicine Scientific Congress
Hanson BM Tao X Kim JG Herlihy NS Klimczak AM Tiegs AW Osman EK Kathleen Hong Seli E Scott RT O-5 NONINVASIVE PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY EXHIBITS HIGH RATES OF DNA AMPLIFICATION FAILURE AND LACKS CONSISTENCY WITH PGT-A USING TROPHOECTODERM BIOPSY Presented at 76th American Society of Reproductive Medicine Scientific Congress
Kim JG Tao X Zhan Y Michael Cheng Zhao T Vanessa Guo Hanson BM Scott RT Chaim Jalas P-756 CONFIRMATION RATE OF WHOLE CHROMOSOME CALLS ON A TARGETED NEXT-GENERATION SEQUENCING PLATFORM ARE HIGHLY CONSISTENT WITH INITIAL TROPHECTODERM BIOPSY Presented at 76th American Society of Reproductive Medicine Scientific Congress
Khader TK Kim JG Franasiak J Zhan Y Seli E Scott RT O-173 ONLY SEGMENTAL OR MOSAIC ANEUPLOID EMBRYOS AVAILABLE FOR TRANSFER: A RARE PHENOMENON IN PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A) CYCLES USING TARGETED NEXT GENERATION SEQUENCING (NGS) Presented at 76th American Society of Reproductive Medicine Scientific Congress
Herlihy NS Klimczak AM Hanson BM Kim JG Tiegs AW Osman EK Seli E Scott RT P-791 ANOTHER CHANCE FOR SUCCESS: THE LIKELIHOOD OF OBTAINING A EUPLOID EMBRYO FOR TRANSFER AFTER AN IVF CYCLE WITH NO EUPLOID EMBRYOS Presented at 76th American Society of Reproductive Medicine Scientific Congress
Herlihy NS Tao X Zhan Y Chaim Jalas Klimczak AM Hanson BM Kim JG Osman EK Tiegs AW Seli E Scott RT Franasiak J P-465 INCREASING MICROBIAL DIVERSITY AND LACTOBACILLUS DOMINANCE OF GENITOURINARY, GASTROINTESTINAL, AND REPRODUCTIVE TRACTS DO NOT ASSOCIATE WITH REPRODUCTIVE OUTCOMES AFTER EUPLOID SINGLE EMBRYO TRANSFER Presented at 76th American Society of Reproductive Medicine Scientific Congress
Tiegs AW Titus S Sameet Mehta Rolando Garcia-Milian Seli E Scott RT P-562 CUMULUS CELL TRANSCRIPTOMIC PROFILES OF OOCYTES THAT RESULT IN WHOLE CHROMOSOME 21 MONOSOMY AND TRISOMY ARE SIGNIFICANTLY DIFFERENT Presented at 76th American Society of Reproductive Medicine Scientific Congress
Tiegs AW Tao X Zhan Y Whitehead CV Seli E George Patounakis Gutmann J Castelbaum AJ Thomas Kim Chaim Jalas Scott RT O-73 A MULTI-CENTER, PROSPECTIVE, BLINDED, NON-SELECTION STUDY EVALUATING THE PREDICTIVE VALUE (PV) OF AN ANEUPLOID DIAGNOSIS WITH PGT-A AND THE IMPACT OF BIOPSY Presented at 76th American Society of Reproductive Medicine Scientific Congress
Tiegs AW Tao X Zhan Y Whitehead CV Hanson BM Kim JG Osman EK Seli E Patounakis G Gutmann J Castelbaum AJ Kim T Chaim Jalas O-77 TRANSFER OUTCOMES OF EMBRYOS WITH PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A) DIAGNOSES OF UNDETERMINED REPRODUCTIVE POTENTIAL: RESULTS FROM A PROSPECTIVE, BLINDED, MULTI-CENTER NON-SELECTION STUDY Presented at 76th American Society of Reproductive Medicine Scientific Congress
ESHRE 2020
Florensa Bargalló M Cladellas Artola A Bellés Fernandez Jimenez Blasco M Herreros Cuesta J Huete Ferriz Garrido N Esbert Algam M Relationship between both euploidy and thawing survival rates and embryo quality, day of biopsy or hatching status in Preimplantation Genetic Testing cycles Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
Hernández-Vargas P Gadea B Lozoya V Legidos V Muñoz M The effect of endometriosis in the chromosomal status and developmental competence of cleavage-stage embryos. Differences with embryos in the blastocyst stage Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
Riqueros M Correlation between 3 qualitative markers of ovarian function with embryo aneuploidy Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
Rodriguez Valderrama F Palomino MC Pla Victori J Requena A Chromosomal abnormalities in males, but not chromosomal polymorphisms, affect the preterm delivery rate in ICSI+PGT cycles Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
Delgado Mendive A Mercader A Escrich L Beltran B Tejera A Grau N Insua F Nohales M Mifsud M Euploidy and embryo quality with single step medium with or without renewal post assisted hatching (AH) in a PGT-A program using Embryoscope dishes Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
Leaver M Kubikova N Tao X Jalas C Wells D O-270 A nobel long-range DNA sequencing approach improves the design of new protocols for preimplantation genetic testing of monogenic disease (PGT-M). Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
Abdala A Elkhatib I Bayram A Arnanz A El-Damen A Lawrenz B Fatemi H De Munck N Influence of culture media on embryo developmental pattern and ploidy status: a sibling oocyte study Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
Arnanz A De Munck N El Khatib I Bayram A El-Damen A Abdala A Melado L Lawrenz B Pacheco A Fatemi H Vitamin D (VitD) in follicular fluid (FF) correlates with the euploid status of the embryo in a VitD deficient Middle Eastern population Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
Niag dos Santos Rocha M Freitas D Carvalho R Oliveira T Santos C Abreu T Teixeira C Almeida A Queiroz L Coelho G O-293 Evaluation of the relation between the value of mitochondrial DNA (MitoScore) and euploid embryo quality Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
Markova D Kagan KO Hoopmann M Abele H Abecia E Fatemi H Lawrenz B Impact of Preimplantation Genetic Testing for Aneuploidies (PGT-A) on first trimester biochemical markers - PAPP-A (placenta associated plasma protein) and free ?-hCG (human chorionic gonadotropin) Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology
SRI 2020
Tiegs A Tao X Whitehead Neal S Osman E Kim J Hanson B Seli E Patounakis G Gutmann JN Castelbaum AJ Scott RT O-084 A multi-center, prospective, blinded, non-selection study evaluating the predictive value (PV) of an aneuploid preimplantation genetic testing for aneuploidy (PGT-A) diagnosis and impact of biopsy Presented at the 67th Annual Meeting of the Society for Reproductive Investigation
ASRM 2019
Nelson SM La Marca A García Velasco JA Göthberg M Jonker DM Mannaerts B O-211 Impact of body weight on ovarian response after individualized or fixed follicle-stimulating hormone dosing in women undergoing ovarian stimulation for in vitro fertilization Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology
SRI 2019
Corachán A Ferrero H Escrig J Monleón J Faus A Cervelló I Pellicer A Eects of Vitamin D in Human Uterine Leiomyoma Growth in a Xenograft Animal Model. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
Gonzalez-Martin R Quiñonero A Pérez S Salsano S Domínguez F Acute DEHP Exposure in Endometrial Epithelial Cells Does Not Phenocopy the Alterations Described in Endometriosis. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2018
Duan J Jiang Z Seli E Tian X Wang T Zhang M Evaluating mitochondrial stress response gene clpp-regulated dna methylome dynamics in female reproductive aging Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology
Kim G Morin SJ Patounakis G Juneau C Neal SA Abc trial: appraisal of body content. Frozen embryo cycles are not impacted by the negative effects of obesity seen in fresh cycles Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
Tiegs W Tao X Landis J Rajchel J Bedard JL Seli E Wells D Fragouli E Scott RT Evaluation of sperm mitochondrial dna copy number as a predictor of in vitro fertilization/intracytoplasmic sperm injection (ivf/icsi) cycle outcomes in a large infertile population Presented at the 65th Annual Meeting of the Society for Reproductive Investigation
Costa-Borges N Spath K Nikitos E Ribustello L Miguel-Escalada I Rink K Kostaras K Psathas P Wells D Calderon G Cytoplasm replacement by spindle transfer demonstrates enhanced embryo development without compromising euploidy rates: pre-clinical study with donor oocytes Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Neal A Goodman LR Morin SJ Werner MD Gueye N Tiegs W Pirtea P Scott RT T-shaped uterine cavity morphology as assessed by three-dimensional ultrasound (3d us) is associated with lower sustained implantation rates and higher clinical loss rates following frozen embryo Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Nohales M Soler N Gonzalez-Picazo A Escriba M Vendrell X Bautista-Llacer R Tena R Pabon D Ploidy condition and developmental competence of unipronuclear embryos Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Dolitsky N Neal SA Olcha M Hong K Werner MD Morin SJ Tiegs W Sun L Scott RT Initial serum human chorionic gonadotropin levels predict live birth outcomes following frozen embryo transfer with and without preimplantation genetic testing for aneuploidy (pgt-a) Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Alegre L Del Gallego R Peura T Bori L Aparicio Ruiz B Adam A Coello A Castello D Meseguer M Embryologists team vs. Automated annotation software outcomes Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Layman L Feinberg E Hurst B Morin SJ Morris J Pisarka M Smith YR Price TM Academic pursuits in board certified reproductive endocrinologists Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Lara-Molina EE Franasiak JM Devesa-Peiro A Florensa M Martin M Lopez M Diaz-Gimeno P Pellicer A Ovarian vitamin d metabolism is conserved despite seasonal variability and follicular maturation Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
ESHRE 2018
Del Gallego R Alegre L Cnaani T Shnizer S Remohí J Meseguer M Clinical validation of a non-invasive embryo selection algorithm combining time-lapse morphokinetics and the oxidative status of spent embryo culture media. Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Liñán A Bayram A Arnanz A Elkhatib I Rubio C Rupali C Garrido N Fatemi H Lawrenz B Comparison of mitochondrial DNA content in euploid and aneuploid embryos at cleavage stage and blastocyst stage with NGS Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Castillo LM Buigues A Pellegrini L Rossi V Klinger F Pellicer A Herraiz S LH gonadoprotection against ovarian damage induced by alkytaing drugs in adult mouse ovaries. Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Devesa A Sebastian-Leon P Garcia-Garcia F Arnau V Pellicer A Diaz-Gimeno P Functional genomic meta-analysis identifies similarities between endometrial-related subfertilities Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Staicu FD Martinez-Soto JC Matas C Protein kinase A modulation by nitric oxide during human sperm capacitation Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Elkhatib I Lawrenz B Linan A Arnanz A Bayram A Fatemi H Comprehensive comparison of Trophectoderm (TE) and Inner cell mass (ICM) by Next Generation Sequencing (NGS) Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Labarta E Herraiz S De Los Santos MJ Marzal A Jose Escribá M Buigues A Pellicer A Autologous mitochondrial transfer (AugmentSM) as a complementary technique to ICSI to improve oocyte and embryo quality in IVF patients. A Randomized Pilot Study. Presented at the 73rd annual meeting of the American Society of Reproductive Medicine
Esbert M Garrido N Ballesteros A Giménez Sanz A Florensa M Predictors of positive sperm retrieval in azoospermic Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
Labarta E Herraiz S De Los Santos MJ Marzal A Jose Escribá M Buigues A Pellicer A Autologous stem cell ovarian transplant to improve ovarian response and reproductive outcomes in poor responder patients Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
SRI 2018
Tao X Zhan Y Scott K Scott RT Seli E DNA methylation is associated with ploidy status, delayed blastulation, and patient age in human embryos Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
ASRM 2017
Alegre L Garrido N Munoz M De los Santos M Remohí J Meseguer M Sperm selection with hyaluronic acid (PICSI) improves LBR in IVF treatments Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
Bedard JL Jalas C Juneau CR Zimmerman RS Scott RT Sustained implantation rate is not impacted by increasing fragile X premutation allele size Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
Colombo S Franasiak JM Kaser DJ Molinaro T Bergh PA Significance of endometrial lining decrease after progesterone start in synthetic frozen embryo transfer (FET) cycles Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology
Dougherty MP Morin SJ Doherty L Bohrer M Leary S Scott RT Goodman L Surgical management of complete uterine/vaginal septum with duplication of the cervix Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology