
Dagan Wells, Ph.D.
Oxford Basic Research Centre
Biografía
Dagan Wells has been actively involved in preimplantation genetic diagnosis (PGD) and the study of human gametes and embryos for 25 over years.He studied genetics at University College London, where he accomplished the first comprehensive chromosome analysis of cells from human preimplantation embryos in 1998. The following year Prof. Wells moved to the United States and joined Reprogenetics, one of the world’s largest providers of PGD services, initiating their highly successful single gene PGD program. Prof. Wells subsequently joined the faculty of Yale University Medical School, where he set-up a research laboratory, before returning to the UK in 2007 to take a position at the University of Oxford, where he remains an Associate Professor. After arriving in Oxford, Prof. Wells established Reprogenetics UK, a laboratory offering state-of-the-art diagnostic services to IVF clinics, which grew to become one of Europe’s most active sites for preimplantation embryo testing. Prof. Wells left Reprogenetics in 2017 in order to take a new role leading molecular genetic research for IVI-RMA.
Prof. Wells’ research continues to focus on genetic factors relevant to gametogenesis and early embryo development and has a strong translational emphasis. His work has encompassed analysis of sperm, oocytes and embryos at various stages of development and has examined aspects of biology including telomeres, mitochondria, transcriptomics, proteomics, epigenetics and DNA sequence variation. Prof. Wells’ research has led to the publication of almost 200 peer-review papers and, in the last decade, has been shortlisted for eighteen major conference prizes (ASRM and ESHRE), winning nine of them. His work has received extensive funding from multiple public and private sources, including the National Institutes of Health (USA), the Medical Research Council (UK) and the National Institute for Health Research (UK).
Prof. Wells has had leadership roles within multiple professional societies, serving on the Executive Boards of organizations such as the PGD-International Society and the PGD Special Interest Group of the ASRM. He has also taken a key role in attempts to improve the quality of PGD laboratories internationally through the introduction of independent Quality Assessment schemes. Prof. Wells has been a member of the Editorial Boards of most of the main journals in the field of Reproductive Medicine and regularly reviews for a wide variety of journals and research funding agencies in the fields of medicine, reproductive biology and genetics. Prof. Wells’ contribution has been recognized with his election to Fellowship of the Royal College of Pathologists, the Royal Society of Biology and the Institute of Biomedical Science.
Prof. Wells has always had a passion for teaching and has successfully guided many PhD and MSc students through their studies. His lectures are known for their clarity and his ability to convey complex genetic concepts in terms that can be readily understood by his audience. As a result, he is one of the most frequently invited speakers at international conferences. Prof. Wells’ commitment to education has extended to involvement as a co-organizer or Advisory Board member of numerous conferences and workshops. He has also assisted with the dissemination of research findings and increasing the public understanding of scientific discoveries through his frequent interactions with the media.
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Formación
BSc (Genetics) | University College London (1992) |
PhD (Genetics) | University College London (1997) |
Post-doctoral Scientist | Universtiy College London (1996-1999) |
Medical Research Council Fellow | University College London (1999-2002) |
Supervisor of Molecular PGD | UCL Centre for PGD (1999-2002) |
Laboratory Director | Reprogenetics LLC (2002-2007) |
Chief Scientific Officer | Reprogenetics LLC (2002-2007) |
Assistant Professor | Yale University Medical School (2004-2007) |
Vice President of Research | Reprogenetics LLC (2007-2017) |
Associate Professor | University of Oxford (2007-present) |
Founder and Managing Director | Reprogenetics UK (2008-2017) |
Research Director | CooperGenomics (2017) |
Director of Molecular Genetic Research | IVI-RMA Global (2018- present) |
Honores y reconocimientos
ASMR Star Award | 2020 |
ASMR Star Award | 2019 |
European Society for Human Reproduction & Embryology, shortlisted the Clinical Science Prize (first author) | 2017 |
American Society of Reproductive Medicine, winner of General Program Prize (collaborator) | 2017 |
European Society for Human Reproduction & Embryology, shortlisted the Basic Science Prize (senior author) | 2016 |
American Society of Reproductive Medicine, STAR Award (recognition for having presented work in at least nine of the previous 10 annual conferences) | 2015-2017 |
European Society for Human Reproduction & Embryology, shortlisted the Clinical Science Prize (senior author) | 2015 |
European Society for Human Reproduction & Embryology, shortlisted the Australian Fertility Society Exchange Award (senior author) | 2015 |
American Society of Reproductive Medicine, shortlisted for the General Program Prize (senior author) | 2015 |
American Society of Reproductive Medicine, winner of Society for Assisted Reproductive Technology prize (senior author) | 2015 |
European Society for Human Reproduction & Embryology, shortlisted the Clinical Science Prize (senior author) | 2014 |
Robert G. Edwards Prize Paper Award for best published paper (Palini et al., 2013 RBMO) | 2014 |
European Society for Human Reproduction & Embryology, winner of the Fertility Society of Australia Exchange Award (senior author) | 2013 |
American Society of Reproductive Medicine, winner of Society for Assisted Reproductive Technology prize (first author) | 2011 |
European Society for Human Reproduction & Embryology, winner of the Basic Science Prize (senior author) | 2011 |
Royal College of Obstetricians and Gynaecologists, best oral free communication (senior author) | 2009 |
European Society for Human Reproduction & Embryology, short-listed for Promising Young Scientist Award (first author) | 2004 |
European Society for Human Reproduction & Embryology, short-listed for Established Scientist Prize (first author) | 2003 |
Mammalian Genetics and Development, first prize paper at the annual meeting. (first author) | 2001 |
American Society of Reproductive Medicine, short-listed for General Program Prize (first author) | 2001 |
American Society of Reproductive Medicine, winner of General Program Prize (first author) | 2000 |
Publicaciones
-
Sperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes.
Tiegs AW Tao X Landis J Zhan Y Franasiak JM Seli E Wells D Fragouli E Scott RT
Reprod Sci. 2020 Jan 28. doi: 10.1007/s43032-020-00163-0. [Epub ahead of print] -
The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes.
ElInati E Zielinska AP McCarthy A Kubikova N Maciulyte V Mahadevaiah S Sangrithi MN Ojarikre O Wells D Niakan KK Schuh M Turner JMA
Nat Commun. 2020 May 25;11(1):2598. doi: 10.1038/s41467-020-16441-z. -
Gene Editing Should Replace Embryo Selection Following PGD.
Wells D Vermeesch JR Simpson JL
Prenat Diagn. 2019 Mar 4. doi: 10.1002/pd.5442. [Epub ahead of print] No abstract available. -
The cytogenetic constitution of human blastocysts: insights from comprehensive chromosome screening strategies.
Fragouli E Munne S Wells D
Hum Reprod Update. 2019 Jan 1;25(1):15-33. doi: 10.1093/humupd/dmy036. -
Pores for thought: preimplantation genetic testing using a nanopore-based DNA sequencer.
Fragouli E Wells D
Fertil Steril, 110(5):853-855, 2018. -
Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice.
Costa-Borges N Spath K Miguel-Escalada I Mestres E Balmaseda R Serafín A Garcia-Jiménez M Vanrell I González J Rink K Wells D Calderón G
Elife. 2020 Apr 29;9:e48591. doi: 10.7554/eLife.48591. -
Coronavirus disease-19 and fertility: viral host entry protein expression in male and female reproductive tissues.
Stanley KE Thomas E Leaver M Wells D
Fertil Steril. 2020 Jul;114(1):33-43. doi: 10.1016/j.fertnstert.2020.05.001. Epub 2020 May 8. -
Non-invasive preimplantation genetic testing (niPGT): the next revolution in reproductive genetics?
Leaver M Wells D
Hum Reprod Update. 2020 Jan 1;26(1):16-42. doi: 10.1093/humupd/dmz033. -
Aneuploidy and recombination in the human preimplantation embryo. Copy number variation analysis and genome-wide polymorphism genotyping
Michalis Konstantinidis Ravichandran K Gunes Z Prates R Goodall N Bo Romana Ribustello L Shanmugama A Pere Colls Munné S Wells D
Reproductive BioMedicine Online April 2020. -
Sperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes.
Tiegs AW Tao X Landis J Zhan Y Franasiak JM Seli E Wells D Fragouli E Scott RT
Reprod Sci. 2020 Jan 28. doi: 10.1007/s43032-020-00163-0. [Epub ahead of print]
- Genome editing reveals a role for OCT4 in human embryogenesis.
Fogarty N, McCarthy A, Snijders KE, Powell BE, Kubikova N, Blakeley P, Lea R, Elder K, Wamaitha S, Daesik K, Maciulyte V, Kleinjung J, Kim J, Wells D, Vallier L, Bertero A, Turner J, Niakan K.
Nature, 550:67-73, 2017. - Mitochondrial DNA quantity as a biomarker for blastocyst implantation potential.
Wells D.
Fertil Steril, 108:742–747, 2017. - The incidence and origin of segmental aneuploidy in human oocytes and preimplantation embryos.
Babariya D, Fragouli E, Alfarawati S, Spath K, Wells D.
Hum Reprod, 32:2549–2560, 2017. - Clinical implications of mitochondrial DNA quantification on pregnancy outcomes: a blinded prospective non-selection study.
Fragouli E, McCaffrey C, Ravichandran K, Spath K, Grifo JA, Munné S, Wells D.
Hum Reprod, 32:2340–2347, 2017. - Mitochondrial DNA Quantification- the devil in the detail.
Wells D, Ravichandran K, McCaffrey C, Grifo J, Morales A, Perloe M, Munné S, Fragouli E.
Hum Reprod, 32:2150–2151, 2017. - Karyomapping: a single centre experience from application of methodology to ongoing pregnancy and live-birth rates.
Ben-Nagi J, Wells D, Doye K, Loutradi K, Exeter H, Drew E, Alfarawati S, Naja R, Serhal P.
Reprod Biomed Online, 35:264–271, 2017. - Detailed investigation into the cytogenetic constitution and pregnancy outcome of replacing mosaic blastocysts detected with the use of high-resolution next-generation sequencing.
Munné S, Blazek J, Large M, Martinez-Ortiz PA, Nisson H, Liu E, Tarozzi N, Borini A, Becker A, Zhang J, Maxwell S, Grifo J, Babariya D, Wells D, Fragouli E.
Fertil Steril, 108:62-71, 2017. - Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.
Zhang J, Liu H, Luo S, Lu Z, Chávez-Badiola A, Liu Z, Yang M, Merhi Z, Silber SJ, Munné S, Konstandinidis M, Wells D, Huang T.
Reprod Biomed Online, 34:361-368, 2017. - Detection of mosaicism at blastocyst stage with the use of high-resolution next-generation sequencing.
Munné S, Wells D.
Fertil Steril, 107:1085–1091, 2017.
-
Current status and future prospects of noninvasive preimplantation genetic testing for aneuploidy.
Fragouli E Wells D
Fertil Steril, 110(3):408-409, 2018. -
The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes.
ElInati E Zielinska AP McCarthy A Kubikova N Maciulyte V Mahadevaiah S Sangrithi MN Ojarikre O Wells D Niakan KK Schuh M Turner JMA
Nat Commun. 2020 May 25;11(1):2598. doi: 10.1038/s41467-020-16441-z. -
Detection of mosaicism at blastocyst stage with the use of high-resolution next-generation sequencing.
Munné S Wells D
Fertil Steril, 107:1085–1091, 2017. -
Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.
Zhang J Liu H Luo S Lu Z Chávez-Badiola A Liu Z Yang M Merhi Z Silber SJ Munné S Konstandinidis M Wells D Huang T
Reprod Biomed Online, 34:361-368, 2017. -
Detailed investigation into the cytogenetic constitution and pregnancy outcome of replacing mosaic blastocysts detected with the use of high-resolution next-generation sequencing.
Munné S Blazek J Large M Martinez-Ortiz PA Nisson H Liu E Tarozzi N Borini A Becker A Zhang J Maxwell S Grifo J Babariya D Wells D Fragouli E
Fertil Steril, 108:62-71, 2017. -
Karyomapping: a single centre experience from application of methodology to ongoing pregnancy and live-birth rates.
Ben-Nagi J Wells D Doye K Exeter H Drew E Alfarawati S Naja R Serhal P Loutradi K
Reprod Biomed Online, 35:264–271, 2017. -
Mitochondrial DNA Quantification- the devil in the detail
Wells D Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munné S Fragouli E
Hum Reprod, 32:2150–2151, 2017. -
Mitochondrial DNA quantity as a biomarker for blastocyst implantation potential.
Wells D
Fertil Steril, 108:742–747, 2017. -
Genome editing reveals a role for OCT4 in human embryogenesis.
Fogarty N McCarthy A Snijders KE Powell BE Kubikova N Blakeley P Lea R Elder K Wamaitha S Daesik K Maciulyte V Kleinjung J Kim J Wells D Vallier L Bertero A Turner J Niakan K
Nature, 550:67-73, 2017. -
Embryos with morphokinetic abnormalities may develop into euploid blastocysts.
Lagalla C Tarozzi N Sciajno R Wells D Santo M Di Nadalini M Distratis V Borini A
Reprod Biomed Online, 34:137–146, 2017. -
Mitochondrial DNA quantification as a tool for embryo viability assessment: retrospective analysis of data from single euploid blastocyst transfers.
Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Wells D Fragouli E
Hum Reprod, 32: 1282-1292, 2017 -
Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts.
Fragouli E Alfarawati S Spath K Babariya D Tarozzi N Borini A Wells D
Hum Genet, 136: 805-819, 2017 -
Clinical implications of mitochondrial DNA quantification on pregnancy outcomes: a blinded prospective non-selection study
Fragouli E McCaffrey C Ravichandran K Spath K Grifo JA Munné S Wells D
Hum Reprod, 32: 2340-2347, 2017. -
The incidence and origin of segmental aneuploidy in human oocytes and preimplantation embryos.
Babariya D Fragouli E Alfarawati S Spath K Wells D
Hum Reprod, Epub, Nov 8, 2017. -
Gene Editing Should Replace Embryo Selection Following PGD.
Wells D Vermeesch JR Simpson JL
Prenat Diagn. 2019 Mar 4. doi: 10.1002/pd.5442. [Epub ahead of print] No abstract available. -
Mitochondrial DNA Quantification-the devil in the detail.
Wells D Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Fragouli E Borini A Becker A Zhang J Maxwell S Grifo J Babariya D Wells D Fragouli E
Hum Reprod, 32: 2150-2151, 2017. -
Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts.
Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Wells D Fragouli E
Hum Genet, 136: 805-819, 2017. -
The cytogenetic constitution of human blastocysts: insights from comprehensive chromosome screening strategies.
Fragouli E Munne S Wells D
Hum Reprod Update. 2019 Jan 1;25(1):15-33. doi: 10.1093/humupd/dmy036. -
Pores for thought: preimplantation genetic testing using a nanopore-based DNA sequencer.
Fragouli E Wells D
Fertil Steril, 110(5):853-855, 2018. -
Continuing to deliver: the evidence base for pre-implantation genetic screening.
Griffin DK Fishel S Gordon T Yaron Y Grifo J Hourvitz A Rechitsky S Elson J Blazek J Fiorentino F Treff N Munne S Leong M Schmutzler A Vereczkey A Ghobara T Nánássy L Large M Hamamah S Anderson R Gianaroli L Wells D
BMJ. 2017 Feb 14;356:j752. doi: 10.1136/bmj.j752. No abstract available -
Current status and future prospects of noninvasive preimplantation genetic testing for aneuploidy.
Fragouli E Wells D
Fertil Steril, 110(3):408-409, 2018. -
Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children
Diot A Dombi E Lodge T Liao C Morten K Carver J Wells D Child T Johnston I Williams S Poulton J
Biochem Soc Trans, 44:1091–1100, 2016. -
Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy.
Ravichandran K Guzman L Escudero T Zheng X Colls P Jordan A Cohen J Wells D Munné S
Reprod Biomed Online, 33:550–559, 2016. -
The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.
Sermon K Capalbo A Cohen J Coonen E De Rycke M De Vos A Delhanty J Fiorentino F Gleicher N Griesinger G Grifo J Handyside A Harper J Kokkali G Mastenbroek S Meldrum D Meseguer M Montag M Munné S Rienzi L Rubio C Scott K Scott RT Simón C Swain J Treff N Ubaldi F Vassena R Vermeesch J Verpoest W Wells D Geraedts J
Mol Hum Reprod, 22:845–857, 2016. -
Why do euploid embryos miscarry? A case-control study comparing the rate of aneuploidy within presumed euploid embryos that resulted in miscarriage or live birth using next-generation sequencing.
Maxwell SM Colls P Hodes-Wertz B McCulloh DH McCaffrey C Wells D Munné S Grifo J
Fertil Steril, 106:1414-1419, 2016. -
Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality.
Cariati F Jaroudi S Alfarawati S Raberi A Alviggi C Pivonello R Wells D
Reprod Biomed Online, 33:404–411, 2016. -
Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.
Hyslop LA Blakeley P Craven L Richardson J Fogarty NM Fragouli E Lamb M Wamaitha SE Prathalingam N Zhang Q O'Keefe H Takeda Y Arizzi L Alfarawati S Tuppen HA Irving L Kalleas D Choudhary M Wells D Murdoch AP Turnbull DM Niakan KK Herbert M
Nature, 534:383–386, 2016. -
Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.
Enciso M Sarasa J Xanthopoulou L Bristow S Bowles M Fragouli E Delhanty J Wells D
Hum Genet, 135:555–568, 2016. -
Preimplantation genetic diagnosis: an overview and recent advances.
Ben-Nagi J Serhal P SenGupta S Doye K Wells D
Obstet Gynaecol, 18:99–106, 2016. -
Current controversies in prenatal diagnosis 4: preimplantation genetic screening should be routinely offered to all preimplantation genetic diagnosis cases.
Harper J Wells D Simpson JL
Prenat Diagn, 36:25–28, 2016. -
Mosaicism: “survival of the fittest” versus “no embryo left behind”.
Munné S Grifo J Wells D
Fertil Steril, 105:1146–1149, 2016. -
Preimplantation genetic diagnosis for infertility.
Wells D Lewin J
In Textbook of Assisted Reproductive technologies, 5th Edition (Informa Healthcare, UK), p346-353. Edited by Gardner D, Weissman A, Howles C, Shoham Z. 2016. -
Detection of mosaicism at blastocyst stage with the use of high-resolution next-generation sequencing.
Munné S Wells D
Fertil Steril, 107:1085–1091, 2017. -
Live birth derived from oocyte spindle transfer to prevent mitochondrial disease.
Zhang J Liu H Luo S Lu Z Chávez-Badiola A Liu Z Yang M Merhi Z Silber SJ Munné S Konstandinidis M Wells D Huang T
Reprod Biomed Online, 34:361-368, 2017. -
Detailed investigation into the cytogenetic constitution and pregnancy outcome of replacing mosaic blastocysts detected with the use of high-resolution next-generation sequencing.
Munné S Blazek J Large M Martinez-Ortiz PA Nisson H Liu E Tarozzi N Borini A Becker A Zhang J Maxwell S Grifo J Babariya D Wells D Fragouli E
Fertil Steril, 108:62-71, 2017. -
Karyomapping: a single centre experience from application of methodology to ongoing pregnancy and live-birth rates.
Ben-Nagi J Wells D Doye K Exeter H Drew E Alfarawati S Naja R Serhal P Loutradi K
Reprod Biomed Online, 35:264–271, 2017. -
Mitochondrial DNA Quantification- the devil in the detail
Wells D Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munné S Fragouli E
Hum Reprod, 32:2150–2151, 2017. -
Mitochondrial DNA quantity as a biomarker for blastocyst implantation potential.
Wells D
Fertil Steril, 108:742–747, 2017. -
Genome editing reveals a role for OCT4 in human embryogenesis.
Fogarty N McCarthy A Snijders KE Powell BE Kubikova N Blakeley P Lea R Elder K Wamaitha S Daesik K Maciulyte V Kleinjung J Kim J Wells D Vallier L Bertero A Turner J Niakan K
Nature, 550:67-73, 2017. -
Embryos with morphokinetic abnormalities may develop into euploid blastocysts.
Lagalla C Tarozzi N Sciajno R Wells D Santo M Di Nadalini M Distratis V Borini A
Reprod Biomed Online, 34:137–146, 2017. -
Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy
Enciso M Sarasa J Xanthopoulou L Bristow S Bowles M Fragouli E Delhanty J Wells D
Hum Genet, 135: 555-568, 2016 -
Mitochondrial DNA quantification as a tool for embryo viability assessment: retrospective analysis of data from single euploid blastocyst transfers.
Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Wells D Fragouli E
Hum Reprod, 32: 1282-1292, 2017 -
Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts.
Fragouli E Alfarawati S Spath K Babariya D Tarozzi N Borini A Wells D
Hum Genet, 136: 805-819, 2017 -
Clinical implications of mitochondrial DNA quantification on pregnancy outcomes: a blinded prospective non-selection study
Fragouli E McCaffrey C Ravichandran K Spath K Grifo JA Munné S Wells D
Hum Reprod, 32: 2340-2347, 2017. -
The incidence and origin of segmental aneuploidy in human oocytes and preimplantation embryos.
Babariya D Fragouli E Alfarawati S Spath K Wells D
Hum Reprod, Epub, Nov 8, 2017. -
Mitochondrial DNA Quantification-the devil in the detail.
Wells D Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Fragouli E Borini A Becker A Zhang J Maxwell S Grifo J Babariya D Wells D Fragouli E
Hum Reprod, 32: 2150-2151, 2017. -
Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts.
Ravichandran K McCaffrey C Grifo J Morales A Perloe M Munne S Wells D Fragouli E
Hum Genet, 136: 805-819, 2017. -
Karyomapping identifies second polar body DNA persisting to the blastocyst stage: implications for embryo biopsy.
Ottolini CS Rogers S Sage K Summers MC Capalbo A Griffin DK Sarasa J Wells D Handyside AH
Reprod Biomed Online, 31:776–782, 2015. -
Karyomapping allows preimplantation genetic diagnosis of a de-novo deletion undetectable using conventional PGD technology.
Giménez C Sarasa J Arjona C Vilamajó E Martínez-Pasarell O Wheeler K Valls G Garcia-Guixé E Wells D
Reprod Biomed Online, 31:770–775, 2015. -
Characterization and quantification of proteins secreted by single human embryos prior to implantation.
Poli M Ori A Child T Jaroudi S Spath K Beck M Wells D
EMBO Mol Med, 7:1465–1479, 2015. -
Validation of next-generation sequencing for comprehensive chromosome screening of embryos.
Kung A Munné S Bankowski B Coates A Wells D
Reprod Biomed Online, 31:760–769, 2015. -
Mitochondrial DNA Assessment to Determine Oocyte and Embryo Viability.
Wells D Fragouli E
Semin Reprod Med, 33:401–409, 2015. -
Live births following Karyomapping of human blastocysts: experience from clinical application of the method.
Konstantinidis M Prates R Goodall N Fischer J Tecson V Lemma T Chua B Jordan A Armenti E Wells D Munné S
Reprod Biomed Online, 31:394–403, 2015. -
Deep impact: sequencing embryo biopsy specimens at increasing depth.
Spath K Wells D
Reprod Biomed Online, 31:1–3, 2015. -
Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential.
Fragouli E Spath K Alfarawati S Kaper F Craig A Michel CE Kokocinski F Cohen J Munné S Wells D
PLOS Genet, 11, 2015. -
Karyomapping - a comprehensive means of simultaneous monogenic and cytogenetic PGD: comparison with standard approaches in real time for Marfan syndrome.
Thornhill AR Handyside AH Ottolini C Natesan SA Taylor J Sage K Harton G Cliffe K Affara N Konstantinidis M Wells D Griffin DK
J Assist Reprod Genet, 32:347–356, 2015. -
Routine use of next-generation sequencing for preimplantation genetic diagnosis of blastomeres obtained from embryos on day 3 in fresh in~vitro fertilization cycles.
?ukaszuk K Pukszta S Wells D Cybulska C Liss J P?óciennik ? Kuczy?ski W Zabielska J
Fertil Steril, 103:1031–1036, 2015. -
Continuing to deliver: the evidence base for pre-implantation genetic screening.
Griffin DK Fishel S Gordon T Yaron Y Grifo J Hourvitz A Rechitsky S Elson J Blazek J Fiorentino F Treff N Munne S Leong M Schmutzler A Vereczkey A Ghobara T Nánássy L Large M Hamamah S Anderson R Gianaroli L Wells D
BMJ. 2017 Feb 14;356:j752. doi: 10.1136/bmj.j752. No abstract available -
Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children
Diot A Dombi E Lodge T Liao C Morten K Carver J Wells D Child T Johnston I Williams S Poulton J
Biochem Soc Trans, 44:1091–1100, 2016. -
Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy.
Ravichandran K Guzman L Escudero T Zheng X Colls P Jordan A Cohen J Wells D Munné S
Reprod Biomed Online, 33:550–559, 2016. -
The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.
Sermon K Capalbo A Cohen J Coonen E De Rycke M De Vos A Delhanty J Fiorentino F Gleicher N Griesinger G Grifo J Handyside A Harper J Kokkali G Mastenbroek S Meldrum D Meseguer M Montag M Munné S Rienzi L Rubio C Scott K Scott RT Simón C Swain J Treff N Ubaldi F Vassena R Vermeesch J Verpoest W Wells D Geraedts J
Mol Hum Reprod, 22:845–857, 2016. -
Why do euploid embryos miscarry? A case-control study comparing the rate of aneuploidy within presumed euploid embryos that resulted in miscarriage or live birth using next-generation sequencing.
Maxwell SM Colls P Hodes-Wertz B McCulloh DH McCaffrey C Wells D Munné S Grifo J
Fertil Steril, 106:1414-1419, 2016. -
Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality.
Cariati F Jaroudi S Alfarawati S Raberi A Alviggi C Pivonello R Wells D
Reprod Biomed Online, 33:404–411, 2016. -
Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.
Hyslop LA Blakeley P Craven L Richardson J Fogarty NM Fragouli E Lamb M Wamaitha SE Prathalingam N Zhang Q O'Keefe H Takeda Y Arizzi L Alfarawati S Tuppen HA Irving L Kalleas D Choudhary M Wells D Murdoch AP Turnbull DM Niakan KK Herbert M
Nature, 534:383–386, 2016. -
Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.
Enciso M Sarasa J Xanthopoulou L Bristow S Bowles M Fragouli E Delhanty J Wells D
Hum Genet, 135:555–568, 2016. -
Preimplantation genetic diagnosis: an overview and recent advances.
Ben-Nagi J Serhal P SenGupta S Doye K Wells D
Obstet Gynaecol, 18:99–106, 2016. -
Current controversies in prenatal diagnosis 4: preimplantation genetic screening should be routinely offered to all preimplantation genetic diagnosis cases.
Harper J Wells D Simpson JL
Prenat Diagn, 36:25–28, 2016. -
Mosaicism: “survival of the fittest” versus “no embryo left behind”.
Munné S Grifo J Wells D
Fertil Steril, 105:1146–1149, 2016. -
Preimplantation genetic diagnosis for infertility.
Wells D Lewin J
In Textbook of Assisted Reproductive technologies, 5th Edition (Informa Healthcare, UK), p346-353. Edited by Gardner D, Weissman A, Howles C, Shoham Z. 2016. -
Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform.
Konstantinidis M Alfarawati S Hurd D Paolucci M Shovelton J Fragouli E Wells D
Fertil Steril, 102:1385–1392, 2014. -
Genome-wide karyomapping accurately identifies the inheritance of single-gene defects in human preimplantation embryos in vitro.
Natesan SA Bladon AJ Coskun S Qubbaj W Prates R Munné S Coonen E Dreesen JC Stevens SJ Paulussen AD Stock-Myer SE Wilton LJ Jaroudi S Wells D Brown AP Handyside AH
Genet Med,16:838–845, 2014. -
Live birth after PGD with confirmation by a comprehensive approach (karyomapping) for simultaneous detection of monogenic and chromosomal disorders.
Natesan SA Handyside AH Thornhill AR Ottolini CS Sage K Summers MC Konstantinidis M Wells D Griffin DK
Reprod Biomed Online, 29:600–605, 2014. -
Human embryonic aneuploidy.
Fragouli E Wells D
Encyclopedia of Life Sciences, Online, 2014. -
Clinical utilization of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation.
Wells D Kaur K Grifo J Glassner M Taylor JC Fragouli E Munné S
J Med Genet, 51:553–562, 2014. -
Telomere length and aneuploidy: clinical and biological insights into human preimplantation embryos.
Simpson JL Wells D
Reprod Biomed Online, 28:531–532, 2014. -
Next-generation sequencing: the dawn of a new era for preimplantation genetic diagnostics.
Wells D
Fertil Steril, 101:1250–1251, 2014. -
Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature.
Fauser B Devroey P Diedrich K Balaban B Bonduelle M de Waal HAD Estella C Ezcurra D Geraedts JP Howles CM Lerner-Geva L Serna J Wells D
Reprod Biomed Online, 28:162–182, 2014. -
Diminished Effect of Maternal Age on Implantation After Preimplantation Genetic Diagnosis With Array Comparative Genomic Hybridization.
Harton GL Munné S Surrey M Grifo J Kaplan B McCulloh DH Griffin DK Wells D PGD Practitioners Group.
Obstet Gynecol Surv, 69:744–745, 2014. -
Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy
Enciso M Sarasa J Xanthopoulou L Bristow S Bowles M Fragouli E Delhanty J Wells D
Hum Genet, 135: 555-568, 2016 -
Karyomapping identifies second polar body DNA persisting to the blastocyst stage: implications for embryo biopsy.
Ottolini CS Rogers S Sage K Summers MC Capalbo A Griffin DK Sarasa J Wells D Handyside AH
Reprod Biomed Online, 31:776–782, 2015. -
Karyomapping allows preimplantation genetic diagnosis of a de-novo deletion undetectable using conventional PGD technology.
Giménez C Sarasa J Arjona C Vilamajó E Martínez-Pasarell O Wheeler K Valls G Garcia-Guixé E Wells D
Reprod Biomed Online, 31:770–775, 2015. -
Characterization and quantification of proteins secreted by single human embryos prior to implantation.
Poli M Ori A Child T Jaroudi S Spath K Beck M Wells D
EMBO Mol Med, 7:1465–1479, 2015. -
Validation of next-generation sequencing for comprehensive chromosome screening of embryos.
Kung A Munné S Bankowski B Coates A Wells D
Reprod Biomed Online, 31:760–769, 2015. -
Mitochondrial DNA Assessment to Determine Oocyte and Embryo Viability.
Wells D Fragouli E
Semin Reprod Med, 33:401–409, 2015. -
Live births following Karyomapping of human blastocysts: experience from clinical application of the method.
Konstantinidis M Prates R Goodall N Fischer J Tecson V Lemma T Chua B Jordan A Armenti E Wells D Munné S
Reprod Biomed Online, 31:394–403, 2015. -
Deep impact: sequencing embryo biopsy specimens at increasing depth.
Spath K Wells D
Reprod Biomed Online, 31:1–3, 2015. -
Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential.
Fragouli E Spath K Alfarawati S Kaper F Craig A Michel CE Kokocinski F Cohen J Munné S Wells D
PLOS Genet, 11, 2015. -
Karyomapping - a comprehensive means of simultaneous monogenic and cytogenetic PGD: comparison with standard approaches in real time for Marfan syndrome.
Thornhill AR Handyside AH Ottolini C Natesan SA Taylor J Sage K Harton G Cliffe K Affara N Konstantinidis M Wells D Griffin DK
J Assist Reprod Genet, 32:347–356, 2015. -
Routine use of next-generation sequencing for preimplantation genetic diagnosis of blastomeres obtained from embryos on day 3 in fresh in~vitro fertilization cycles.
?ukaszuk K Pukszta S Wells D Cybulska C Liss J P?óciennik ? Kuczy?ski W Zabielska J
Fertil Steril, 103:1031–1036, 2015. -
Morphological and cytogenetic assessment of cleavage and blastocyst stage embryos.
Fragouli E Alfarawati S Spath K Wells D
Mol Hum Reprod, 20:117–126, 2013. -
The transcriptome of follicular cells: biological insights and clinical implications for the treatment of infertility.
Fragouli E Lalioti MD Wells D
Hum Reprod Update, 20:1–11, 2013. -
The origin and impact of embryonic aneuploidy.
Fragouli E Alfarawati S Spath K Jaroudi S Sarasa J Enciso M Wells D
Hum Genet, 132:1001–1013, 2013. -
Questions about the accuracy of polar body analysis for preimplantation genetic screening.
Fragouli E Wells D
Hum Reprod, 28:1731–1732, 2013. -
Genomic DNA in human blastocoele fluid.
Palini S Galluzzi L Stefani S De Bianchi M Wells D Magnani M Bulletti C
Reprod Biomed Online, 26:603–610, 2013. -
Increased numbers of DNA-damaged spermatozoa in samples presenting an elevated rate of numerical chromosome abnormalities.
Enciso M Alfarawati S Wells D
Hum Reprod, 28:1707–1715, 2013. -
Gamete and embryo assessment in assisted reproduction: emerging technologies
Gardner D Sakkas D Seli E Wells D
(Springer Scientific). 2013. -
High-density SNP arrays and next generation sequencing for pre-implantation genetic diagnosis.
Handyside A Wells D
In Gamete and embryo assessment in assisted reproduction: emerging technologies (Springer Scientific), p135-146. Edited by Gardner, D., Sakkas, D., Seli, E. and Wells, D. 2013. -
Transcriptomic analysis of cumulus and granulosa cells as a marker of embryo viability.
Fragouli E Wells D
Gamete and embryo assessment in assisted reproduction: emerging technologies. p185-192. Edited by Gardner D, Sakkas D, Seli E, Wells D. (Springer Scientific). 2013. -
Alterations in the gene expression of aneuploid oocytes and associated cumulus cells.
Wells D
Biology and Pathology of the Oocyte, Role in Fertility and Reproductive Medicine (Cambridge University Press), p346-352. Edited by Eichenlaub-Ritter U, Gosden R, Trounson A. 2013. -
The Textbook of Clinical Embryology
Coward Wells D
(Cambridge University Press, UK). 2013. -
Preimplantation genetic screening.
Wells D
The Textbook of Clinical Embryology (Cambridge University Press, UK). p357-363. Edited by Coward K. and Wells D. 2013. -
Preimplantation genetic diagnosis.
Wells D Fragouli E
The Textbook of Clinical Embryology (Cambridge University Press, UK). p346-356. Edited by Coward K. and Wells D. 2013. -
Successful Live Birth following Preimplantation Genetic Diagnosis for Phenylketonuria in Day 3 Embryos by Specific Mutation Analysis and Elective Single Embryo Transfer.
Lavery S Abdo D JIMD Reports Kotrotsou M Trew G Konstantinidis M Wells D
JIMD Reports, 7:49–54, 2012. -
Microarray-CGH for the Assessment of Aneuploidy in Human Polar Bodies and Oocytes.
Jaroudi S Wells D
Methods in Molecular Biology, 957:267–283, 2012. -
Embryos of Robertsonian Translocation Carriers Exhibit a Mitotic Interchromosomal Effect That Enhances Genetic Instability during Early Development.
Alfarawati S Fragouli E Colls P Wells D
PLoS Genet, 8, 2012. -
Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLC?) from an infertile man by use of minisequencing of individual sperm and expression in somatic
Kashir J Konstantinidis M Jones C Heindryckx B Sutter P De Parrington J Wells D Coward K
Fertil Steril, 98:423–431, 2012. -
Development of a novel synthetic oligopeptide for the detection of DNA damage in human spermatozoa.
Enciso M Pieczenik G Cohen J Wells D
Hum Reprod, 27:2254–2266, 2012. -
Alteration of gene expression in human cumulus cells as a potential indicator of oocyte aneuploidy.
Fragouli E Wells D Iager AE Kayisli UA Patrizio P
Hum Reprod, 27:2559–2568, 2012. -
Aneuploidy Screening for Embryo Selection.
Fragouli E Wells D
Semin Reprod Med, 30:289–301, 2012. -
Biomolecules of Human Female fertility - Potential Therapeutic Targets for Pharmaceutical Design.
Huang Z Fragouli E Wells D
Curr Pharm Des, 18:310–324, 2012. -
Transcriptomic analysis of follicular cells provides information on the chromosomal status and competence of unfertilized oocytes.
Fragouli E Wells D
Expert Rev Mol Diagn, 12:1–4, 2012. -
Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes.
Munné S Held KR Magli CM Ata B Wells D Fragouli E Baukloh V Fischer R Gianaroli L
Fertil Steril, 97:935–942, 2012. -
PGD and aneuploidy screening for 24 chromosomes by genome-wide SNP analysis: a responsible path towards greater utility.
Bisignano A Wells D Harton G Munné S
Reprod Biomed Online, 24:4–5, 2012. -
Preimplantation genetic diagnosis (PGD), preimplantation genetic screening (PGS) and the transfer of in vitro fertilized embryos.
Wells D
In Brenner’s Online Encyclopedia of Genetics (Elsevier). Edited by Maloy S, Hughes K. 2012. -
Cumulus cell gene expression in assessment of oocyte quality.
Wells D
In Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices (Springer, NY, USA), p127-132. Edited by Agarwal, A., Varghese, A., Nagy, Z. 2012. -
Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform.
Konstantinidis M Alfarawati S Hurd D Paolucci M Shovelton J Fragouli E Wells D
Fertil Steril, 102:1385–1392, 2014. -
Genome-wide karyomapping accurately identifies the inheritance of single-gene defects in human preimplantation embryos in vitro.
Natesan SA Bladon AJ Coskun S Qubbaj W Prates R Munné S Coonen E Dreesen JC Stevens SJ Paulussen AD Stock-Myer SE Wilton LJ Jaroudi S Wells D Brown AP Handyside AH
Genet Med,16:838–845, 2014. -
Live birth after PGD with confirmation by a comprehensive approach (karyomapping) for simultaneous detection of monogenic and chromosomal disorders.
Natesan SA Handyside AH Thornhill AR Ottolini CS Sage K Summers MC Konstantinidis M Wells D Griffin DK
Reprod Biomed Online, 29:600–605, 2014. -
Human embryonic aneuploidy.
Fragouli E Wells D
Encyclopedia of Life Sciences, Online, 2014. -
Clinical utilization of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation.
Wells D Kaur K Grifo J Glassner M Taylor JC Fragouli E Munné S
J Med Genet, 51:553–562, 2014. -
Telomere length and aneuploidy: clinical and biological insights into human preimplantation embryos.
Simpson JL Wells D
Reprod Biomed Online, 28:531–532, 2014. -
Next-generation sequencing: the dawn of a new era for preimplantation genetic diagnostics.
Wells D
Fertil Steril, 101:1250–1251, 2014. -
Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature.
Fauser B Devroey P Diedrich K Balaban B Bonduelle M de Waal HAD Estella C Ezcurra D Geraedts JP Howles CM Lerner-Geva L Serna J Wells D
Reprod Biomed Online, 28:162–182, 2014. -
Diminished Effect of Maternal Age on Implantation After Preimplantation Genetic Diagnosis With Array Comparative Genomic Hybridization.
Harton GL Munné S Surrey M Grifo J Kaplan B McCulloh DH Griffin DK Wells D PGD Practitioners Group.
Obstet Gynecol Surv, 69:744–745, 2014. -
A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC?) leads to male infertility.
Kashir J Konstantinidis M Jones C Lemmon B Lee HC Hamer R Heindryckx B Deane CM De Sutter P Fissore RA Parrington J Wells D Coward K
Hum Reprod, 27:222–231, 2011. -
The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy.
Fragouli E Alfarawati S Goodall N Sanchez-Garcia JF Colls P Wells D
Mol Hum Reprod, 17:286–295, 2011. -
Polar bodies: their biological mystery and clinical meaning.
Wells D Hillier SG
Mol Hum Reprod, 17:273–274, 2011. -
First births after preimplantation genetic diagnosis of structural chromosome abnormalities using comparative genomic hybridization and microarray analysis.
Alfarawati S Fragouli E Colls P Wells D
Hum Reprod, 26:1560–1574, 2011. -
Chromosome Abnormalities in the Human Oocyte.
Fragouli E Wells D Delhanty J
Cytogenet Genome Res, 133:107–118, 2011 -
PGD and aneuploidy screening for 24 chromosomes: advantages and disadvantages of competing platforms.
Bisignano A Wells D Harton G Munné S
Reprod Biomed Online, 23:677–685, 2011. -
Aneuploidy in the Human Blastocyst
Fragouli E Wells D
Cytogenet Genome Res, 133:149–159, 2011. -
Reproductive medicine and beyond.
Wells D
Expert Rev Obstet Gynecol, 6:371–376, 2011. -
A skewed sex ratio following blastocyst culture is a consequence of embryo grading systems that prioritise male embryos for transfer.
Wells D Alfarawati S Fragouli E
BJOG An Int J Obstet Gynaecol, 118:381, 2011. -
How to improve IVF success rates and increase access to treatment: back to basics or more technology?
Wells D
Expert Rev Obstet Gynecol, 6:19–22, 2011. -
The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender.
Alfarawati S Fragouli E Colls P Stevens J Gutiérrez-Mateo C Schoolcraft WB Katz-Jaffe MG Wells D
Fertil Steril, 95:520–524, 2011. -
Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos.
Gutiérrez-Mateo C Colls P Sánchez-Garcia J Escudero T Prates R Ketterson K Wells D Munné S
Fertil Steril, 95:953–958, 2011. -
Therapeutic treatments of mtDNA diseases at the earliest stages of human development.
Chiaratti MR Meirelles FV Wells D Poulton J
Mitochondrion, 11:820–828, 2011. -
Molecular aspects of follicular development.
Huang Z Wells D
In Principles & Practice of Fertility Preservation (Cambridge University Press, UK), p114-128. Edited by Donnez J, Kim S. 2011. -
Morphological and cytogenetic assessment of cleavage and blastocyst stage embryos.
Fragouli E Alfarawati S Spath K Wells D
Mol Hum Reprod, 20:117–126, 2013. -
The transcriptome of follicular cells: biological insights and clinical implications for the treatment of infertility.
Fragouli E Lalioti MD Wells D
Hum Reprod Update, 20:1–11, 2013. -
The origin and impact of embryonic aneuploidy.
Fragouli E Alfarawati S Spath K Jaroudi S Sarasa J Enciso M Wells D
Hum Genet, 132:1001–1013, 2013. -
Questions about the accuracy of polar body analysis for preimplantation genetic screening.
Fragouli E Wells D
Hum Reprod, 28:1731–1732, 2013. -
Genomic DNA in human blastocoele fluid.
Palini S Galluzzi L Stefani S De Bianchi M Wells D Magnani M Bulletti C
Reprod Biomed Online, 26:603–610, 2013. -
Increased numbers of DNA-damaged spermatozoa in samples presenting an elevated rate of numerical chromosome abnormalities.
Enciso M Alfarawati S Wells D
Hum Reprod, 28:1707–1715, 2013. -
Gamete and embryo assessment in assisted reproduction: emerging technologies
Gardner D Sakkas D Seli E Wells D
(Springer Scientific). 2013. -
High-density SNP arrays and next generation sequencing for pre-implantation genetic diagnosis.
Handyside A Wells D
In Gamete and embryo assessment in assisted reproduction: emerging technologies (Springer Scientific), p135-146. Edited by Gardner, D., Sakkas, D., Seli, E. and Wells, D. 2013. -
Transcriptomic analysis of cumulus and granulosa cells as a marker of embryo viability.
Fragouli E Wells D
Gamete and embryo assessment in assisted reproduction: emerging technologies. p185-192. Edited by Gardner D, Sakkas D, Seli E, Wells D. (Springer Scientific). 2013. -
Alterations in the gene expression of aneuploid oocytes and associated cumulus cells.
Wells D
Biology and Pathology of the Oocyte, Role in Fertility and Reproductive Medicine (Cambridge University Press), p346-352. Edited by Eichenlaub-Ritter U, Gosden R, Trounson A. 2013. -
The Textbook of Clinical Embryology
Coward Wells D
(Cambridge University Press, UK). 2013. -
Preimplantation genetic screening.
Wells D
The Textbook of Clinical Embryology (Cambridge University Press, UK). p357-363. Edited by Coward K. and Wells D. 2013. -
Preimplantation genetic diagnosis.
Wells D Fragouli E
The Textbook of Clinical Embryology (Cambridge University Press, UK). p346-356. Edited by Coward K. and Wells D. 2013. -
Cytogenetic analysis of human blastocysts with the use of FISH, CGH and aCGH: scientific data and technical evaluation.
Fragouli E Alfarawati S Daphnis D Goodall N Mania A Griffiths T Gordon T Wells D
Hum Reprod, 26:480–490, 2010. -
The human oocyte and cumulus cells relationship: new insights from the cumulus cell transcriptome.
Huang Z Wells D
MHR Basic Sci Reprod Med, 16:715–725, 2010. -
Toward a method for automatic grading of microscope human embryo images.
Filho ES Noble JA Wells D
IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 2010. -
A Review on Automatic Analysis of Human Embryo Microscope Images.
Filho E Noble JA Wells D
Open Biomed Eng J, 4:170–177, 2010. -
Clinical application of comprehensive chromosomal screening at the blastocyst stage.
Schoolcraft WB Fragouli E Stevens J Munne S Katz-Jaffe MG Wells D
Fertil Steril, 94:1700–1706, 2010. -
Transmission of Mitochondrial DNA Diseases and Ways to Prevent Them.
Poulton J Chiaratti MR Meirelles FV Kennedy S Wells D Holt IJ
PLoS Genet, 6, 2010. -
Towards a non-invasive assessment of oocyte competence: gene expression approaches
Wells D Fragouli E
Journal of Reproductive Medicine and Endocrinology, 7:233-235, 2010. -
Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes.
Munné S Wells D Cohen J
Fertil Steril, 94:408–430, 2010. -
Microarrays and CGH for PGD of chromosome abnormalities and gene defects.
Munné S Harton G Held K Wells D
Journal of Reproductive Medicine and Endocrinology, 7:236-239, 2010 -
Embryo aneuploidy and the role of morphological and genetic screening.
Wells D
Reprod Biomed Online, 21:274–277, 2010. -
Transcriptomic profiling of human oocytes: association of meiotic aneuploidy and altered oocyte gene expression.
Fragouli E Bianchi V Patrizio P Obradors A Huang Z Borini A Delhanty J Wells D
Mol Hum Reprod, 16:570–582, 2010. -
Comprehensive chromosome screening of polar bodies and blastocysts from couples experiencing repeated implantation failure.
Fragouli E Katz-Jaffe M Alfarawati S Stevens J Colls P Goodall N Tormasi S Gutierrez-Mateo C Prates R Schoolcraft WB Munné S Wells D
Fertil Steril, 94:875–887, 2010. -
Improved detection of aneuploid blastocysts using a new 12-chromosome FISH test.
Munné S Fragouli E Colls P Katz-Jaffe MG Schoolcraft WB Wells D
Reprod Biomed Online, 20:92–97, 2010. -
Successful Live Birth following Preimplantation Genetic Diagnosis for Phenylketonuria in Day 3 Embryos by Specific Mutation Analysis and Elective Single Embryo Transfer.
Lavery S Abdo D JIMD Reports Kotrotsou M Trew G Konstantinidis M Wells D
JIMD Reports, 7:49–54, 2012. -
Microarray-CGH for the Assessment of Aneuploidy in Human Polar Bodies and Oocytes.
Jaroudi S Wells D
Methods in Molecular Biology, 957:267–283, 2012. -
Embryos of Robertsonian Translocation Carriers Exhibit a Mitotic Interchromosomal Effect That Enhances Genetic Instability during Early Development.
Alfarawati S Fragouli E Colls P Wells D
PLoS Genet, 8, 2012. -
Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLC?) from an infertile man by use of minisequencing of individual sperm and expression in somatic
Kashir J Konstantinidis M Jones C Heindryckx B Sutter P De Parrington J Wells D Coward K
Fertil Steril, 98:423–431, 2012. -
Development of a novel synthetic oligopeptide for the detection of DNA damage in human spermatozoa.
Enciso M Pieczenik G Cohen J Wells D
Hum Reprod, 27:2254–2266, 2012. -
Alteration of gene expression in human cumulus cells as a potential indicator of oocyte aneuploidy.
Fragouli E Wells D Iager AE Kayisli UA Patrizio P
Hum Reprod, 27:2559–2568, 2012. -
Aneuploidy Screening for Embryo Selection.
Fragouli E Wells D
Semin Reprod Med, 30:289–301, 2012. -
Biomolecules of Human Female fertility - Potential Therapeutic Targets for Pharmaceutical Design.
Huang Z Fragouli E Wells D
Curr Pharm Des, 18:310–324, 2012. -
Transcriptomic analysis of follicular cells provides information on the chromosomal status and competence of unfertilized oocytes.
Fragouli E Wells D
Expert Rev Mol Diagn, 12:1–4, 2012. -
Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes.
Munné S Held KR Magli CM Ata B Wells D Fragouli E Baukloh V Fischer R Gianaroli L
Fertil Steril, 97:935–942, 2012. -
Preventing transmission of maternally inherited mitochondrial DNA diseases.
Poulton J Kennedy S Oakeshott P Wells D
BMJ, 338:94, 2009. -
PGD and aneuploidy screening for 24 chromosomes by genome-wide SNP analysis: a responsible path towards greater utility.
Bisignano A Wells D Harton G Munné S
Reprod Biomed Online, 24:4–5, 2012. -
Comparative genomic hybridization of oocytes and first polar bodies from young donors.
Fragouli E Escalona A Gutiérrez-Mateo C Tormasi S Alfarawati S Sepulveda S Wells D Munné S
Reprod Biomed Online, 19:228–237, 2009. -
Preimplantation genetic diagnosis (PGD), preimplantation genetic screening (PGS) and the transfer of in vitro fertilized embryos.
Wells D
In Brenner’s Online Encyclopedia of Genetics (Elsevier). Edited by Maloy S, Hughes K. 2012. -
The role of preimplantation genetic diagnosis in diagnosing embryo aneuploidy.
Munné S Howles CM Wells D
Curr Opin Obstet Gynecol, 21:442–449, 2009. -
Cumulus cell gene expression in assessment of oocyte quality.
Wells D
In Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices (Springer, NY, USA), p127-132. Edited by Agarwal, A., Varghese, A., Nagy, Z. 2012. -
Preimplantation genetic diagnosis of single-gene disorders: experience with more than 200 cycles conducted by a reference laboratory in the United States.
Gutiérrez-Mateo C Sánchez-Garcia JF Fischer J Tormasi S Cohen J Munné S Wells D
Fertil Steril, 92:1544–1556, 2009. -
Preimplantation genetics.
Delhanty JDA Wells D
In Preimplantation Genetic Diagnosis (Cambridge University Press, UK), p137-150. Edited by Harper, J. 2009. -
Comprehensive molecular cytogenetic analysis of the human blastocyst stage.
Fragouli E Lenzi M Ross R Katz-Jaffe M Schoolcraft WB Wells D
Hum Reprod, 23:2596–2608, 2008. -
Birth of a healthy boy after a double factor PGD in a couple carrying a genetic disease and at risk for aneuploidy.
Obradors A Fernandez E Oliver-Bonet M Rius M de la Fuente A Wells D Benet J Navarro J
Hum Reprod, 23:1949–1956, 2008. -
Gene expression profiling of human oocytes at different maturational stages and after in vitro maturation.
Wells D Patrizio P
Am J Obstet Gynecol, 198:455, 2008. -
Use of comprehensive chromosomal screening for embryo assessment: microarrays and CGH.
Wells D Alfarawati S Fragouli E
Mol Hum Reprod, 14:703–710, 2008. -
A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC?) leads to male infertility.
Kashir J Konstantinidis M Jones C Lemmon B Lee HC Hamer R Heindryckx B Deane CM De Sutter P Fissore RA Parrington J Wells D Coward K
Hum Reprod, 27:222–231, 2011. -
The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy.
Fragouli E Alfarawati S Goodall N Sanchez-Garcia JF Colls P Wells D
Mol Hum Reprod, 17:286–295, 2011. -
Polar bodies: their biological mystery and clinical meaning.
Wells D Hillier SG
Mol Hum Reprod, 17:273–274, 2011. -
First births after preimplantation genetic diagnosis of structural chromosome abnormalities using comparative genomic hybridization and microarray analysis.
Alfarawati S Fragouli E Colls P Wells D
Hum Reprod, 26:1560–1574, 2011. -
Chromosome Abnormalities in the Human Oocyte.
Fragouli E Wells D Delhanty J
Cytogenet Genome Res, 133:107–118, 2011 -
Molecular methods for selection of the ideal oocyte.
Patrizio P Fragouli E Bianchi V Borini A Wells D
Reprod Biomed Online, 15:346–353, 2007. -
PGD and aneuploidy screening for 24 chromosomes: advantages and disadvantages of competing platforms.
Bisignano A Wells D Harton G Munné S
Reprod Biomed Online, 23:677–685, 2011. -
Maternal age-related differential global expression profiles observed in human oocytes.
Steuerwald NM Bermúdez MG Wells D Munné S Cohen J
Reprod Biomed Online, 14:700–708, 2007. -
Aneuploidy in the Human Blastocyst
Fragouli E Wells D
Cytogenet Genome Res, 133:149–159, 2011. -
Single cell diagnosis using comparative genomic hybridization after preliminary DNA amplification still needs more tweaking: too many miscalls.
Fragouli E Delhanty JD Wells D
Fertil Steril, 88:247–248, 2007. -
Reproductive medicine and beyond.
Wells D
Expert Rev Obstet Gynecol, 6:371–376, 2011. -
Removal of 2 cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests that are used to enhance implantation rates.
Cohen J Wells D Munné S
Fertil Steril, 87:496–503, 2007. -
A skewed sex ratio following blastocyst culture is a consequence of embryo grading systems that prioritise male embryos for transfer.
Wells D Alfarawati S Fragouli E
BJOG An Int J Obstet Gynaecol, 118:381, 2011. -
Future genetic and other technologies for assessing embryos.
Wells D
In Handbook of Embryo Evaluation (Taylor and Francis, UK) p287-300. Edited by Cohen, J. and Elder, K. 2007. -
How to improve IVF success rates and increase access to treatment: back to basics or more technology?
Wells D
Expert Rev Obstet Gynecol, 6:19–22, 2011. -
The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender.
Alfarawati S Fragouli E Colls P Stevens J Gutiérrez-Mateo C Schoolcraft WB Katz-Jaffe MG Wells D
Fertil Steril, 95:520–524, 2011. -
Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos.
Gutiérrez-Mateo C Colls P Sánchez-Garcia J Escudero T Prates R Ketterson K Wells D Munné S
Fertil Steril, 95:953–958, 2011. -
Therapeutic treatments of mtDNA diseases at the earliest stages of human development.
Chiaratti MR Meirelles FV Wells D Poulton J
Mitochondrion, 11:820–828, 2011. -
Molecular aspects of follicular development.
Huang Z Wells D
In Principles & Practice of Fertility Preservation (Cambridge University Press, UK), p114-128. Edited by Donnez J, Kim S. 2011. -
Increased susceptibility to maternal aneuploidy demonstrated by comparative genomic hybridization analysis of human MII oocytes and first polar bodies.
Fragouli E Wells D Whalley KM Mills JA Faed MJW Delhanty JDA
Cytogenet Genome Res, 114:30–38, 2006. -
Use of Real-Time Polymerase Chain Reaction to Measure Gene Expression in Single Cells.
Wells D
In Single Cell Diagnostics: Methods and Protocols (Humana Press, USA), p125-134. Edited by Thornhill, A. 2006. -
Preimplantation genetic diagnosis (PGD) of monogenic disease: PCR-based methods for the identification of mutations single cells.
Wells D
PCR: Methods Express (Scion), p159-172. Edited by Hughes, S. 2006. -
Complete cytogenetic investigation of oocytes from a young cancer patient with the use of comparative genomic hybridisation reveals meiotic errors.
Fragouli E Wells D Doshi A Gotts S Harper JC Delhanty JDA
Prenat Diagn, 26:71–76, 2005. -
A successful strategy for Preimplantation Genetic Diagnosis of betathalassemia and simultaneous detection of Down's syndrome using multiplex fluorescent PCR.
Piyamongkol W Vutyavanich T Piyamongkol S Wells D Kunaviktikul C Tongsong T Chaovisitsaree S Saetung R Sanguansermsri T
J Med Assoc Thai, 89:918-27, 2006. -
Cytogenetic analysis of human blastocysts with the use of FISH, CGH and aCGH: scientific data and technical evaluation.
Fragouli E Alfarawati S Daphnis D Goodall N Mania A Griffiths T Gordon T Wells D
Hum Reprod, 26:480–490, 2010. -
The human oocyte and cumulus cells relationship: new insights from the cumulus cell transcriptome.
Huang Z Wells D
MHR Basic Sci Reprod Med, 16:715–725, 2010. -
Toward a method for automatic grading of microscope human embryo images.
Filho ES Noble JA Wells D
IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 2010. -
Association of abnormal morphology and altered gene expression in human preimplantation embryos.
Wells D Bermúdez MG Steuerwald N Malter HE Thornhill AR Cohen J
Fertil Steril, 84:343–355, 2005. -
A Review on Automatic Analysis of Human Embryo Microscope Images.
Filho E Noble JA Wells D
Open Biomed Eng J, 4:170–177, 2010. -
Clinical application of comprehensive chromosomal screening at the blastocyst stage.
Schoolcraft WB Fragouli E Stevens J Munne S Katz-Jaffe MG Wells D
Fertil Steril, 94:1700–1706, 2010. -
Transmission of Mitochondrial DNA Diseases and Ways to Prevent Them.
Poulton J Chiaratti MR Meirelles FV Kennedy S Wells D Holt IJ
PLoS Genet, 6, 2010. -
Towards a non-invasive assessment of oocyte competence: gene expression approaches
Wells D Fragouli E
Journal of Reproductive Medicine and Endocrinology, 7:233-235, 2010. -
Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes.
Munné S Wells D Cohen J
Fertil Steril, 94:408–430, 2010. -
Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation development.
Wells D Bermudez MG Steuerwald N Thornhill AR Walker DL Malter H Delhanty JDA Cohen J
Hum Reprod, 20:1339–1348, 2005. -
Microarrays and CGH for PGD of chromosome abnormalities and gene defects.
Munné S Harton G Held K Wells D
Journal of Reproductive Medicine and Endocrinology, 7:236-239, 2010 -
Embryo aneuploidy and the role of morphological and genetic screening.
Wells D
Reprod Biomed Online, 21:274–277, 2010. -
Transcriptomic profiling of human oocytes: association of meiotic aneuploidy and altered oocyte gene expression.
Fragouli E Bianchi V Patrizio P Obradors A Huang Z Borini A Delhanty J Wells D
Mol Hum Reprod, 16:570–582, 2010. -
Comprehensive chromosome screening of polar bodies and blastocysts from couples experiencing repeated implantation failure.
Fragouli E Katz-Jaffe M Alfarawati S Stevens J Colls P Goodall N Tormasi S Gutierrez-Mateo C Prates R Schoolcraft WB Munné S Wells D
Fertil Steril, 94:875–887, 2010. -
Aneuploidy 12 in a Robertsonian (13;14) carrier: Case report.
Gutiérrez-Mateo C Gadea L Benet J Wells D Munné S Navarro J
Hum Reprod, 20:1256–1260, 2005. -
Improved detection of aneuploid blastocysts using a new 12-chromosome FISH test.
Munné S Fragouli E Colls P Katz-Jaffe MG Schoolcraft WB Wells D
Reprod Biomed Online, 20:92–97, 2010. -
Aneuploidy study of human oocytes first polar body comparative genomic hybridization and metaphase II fluorescence in situ hybridization analysis.
Gutiérrez CM Benet J Wells D Colls P Bermudez MG Sánchez-García JF Egozcue J Navarro J Munné S
Hum Reprod, 19:2859-2868, 2004. -
Reliability of comparative genomic hybridization to detect chromosome abnormalities in first polar bodies and metaphase II oocytes.
Gutiérrez-Mateo C Wells D Benet J Sánchez-García JF Bermúdez MG Belil I Egozcue J Munné S Navarro J
Hum Reprod, 19:2118–2125, 2004. -
Advances in preimplantation genetic diagnosis.
Wells D
Eur J Obstet Gynecol Reprod Biol, 115:S97-S101, 2004. -
Expression profiles of individual human oocytes using microarray technology.
Bermúdez MG Wells D Malter H Munné S Cohen J Steuerwald NM
Reprod Biomed Online, 8:325–337, 2004. -
Microarrays for Analysis and Diagnosis of Human Embryos
Wells D Bermudez MG Steuerwald N Chu L Weier U Cohen J Munne S
Fertil Steril, 80:118, 2003. -
Preventing transmission of maternally inherited mitochondrial DNA diseases.
Poulton J Kennedy S Oakeshott P Wells D
BMJ, 338:94, 2009. -
Comparative genomic hybridization of oocytes and first polar bodies from young donors.
Fragouli E Escalona A Gutiérrez-Mateo C Tormasi S Alfarawati S Sepulveda S Wells D Munné S
Reprod Biomed Online, 19:228–237, 2009. -
The role of preimplantation genetic diagnosis in diagnosing embryo aneuploidy.
Munné S Howles CM Wells D
Curr Opin Obstet Gynecol, 21:442–449, 2009. -
Preimplantation genetic diagnosis of single-gene disorders: experience with more than 200 cycles conducted by a reference laboratory in the United States.
Gutiérrez-Mateo C Sánchez-Garcia JF Fischer J Tormasi S Cohen J Munné S Wells D
Fertil Steril, 92:1544–1556, 2009. -
Preimplantation genetics.
Delhanty JDA Wells D
In Preimplantation Genetic Diagnosis (Cambridge University Press, UK), p137-150. Edited by Harper, J. 2009. -
Whole genome amplification/hybridization following ooplasmic aspiration reveals no evidence of genomic DNA disturbance
Malter HE Wells D Bermudez MG Cohen J
Fertil Steril, 80:118, 2003. -
Questions concerning the suitability of comparative genomic hybridization for preimplantation genetic diagnosis.
Munné S Wells D
Fertil Steril, 80:871–872, 2003. -
Detailed investigation of factors influencing amplification efficiency and allele drop-out in single cell PCR: implications for preimplantation genetic diagnosis.
Piyamongkol W Bermudez MG Harper JC Wells D
Mol Hum Reprod, 9:411–420, 2003. -
Single-cell sequencing and mini-sequencing for preimplantation genetic diagnosis.
Bermudez MG Piyamongkol W Tomaz S Dudman E Sherlock JK Wells D
Prenat Diagn, 23:669–677, 2003. -
Cytogenetics in reproductive medicine: The contribution of comparative genomic hybridization (CGH).
Wells D Levy B
BioEssays, 25:289–300, 2003. -
BRCA1/2 Mutation Status Influences Somatic Genetic Progression in Inherited and Sporadic Epithelial Ovarian Cancer Cases.
Ramus SJ Pharoah PD Harrington P Pye C Werness B Bobrow L Ayhan Wells D Fishman A Gore M Dicioccio R Piver MS Whittemore AS Ponder BA Gayther SA
Cancer Research 63:417-423, 2003. -
Whole-genome amplification.
Wells D
In Encyclopaedia of the Human Genome. (Nature Publishing Group, UK). 2003. -
Whole genome amplification and comparative genomic hybridization (CGH).
Wells D Bermudez M
In PCR Technology: Current Innovations, 2nd edition (CRC Press, USA), p349-359. Edited by Weissensteiner T, Griffin HG, Griffin A. 2003. -
Diagnóstico Genético de Pré-implantação: A Visão do Clinico.
Munné S Wells D Sable D
In Reprodução Humana Assistida. (Atheneu, Brazil) p189-198. Edited by Scheffer B, Remohí J, García-Velasco JA, Pellicer A, Simón C. 2003. -
Preimplantation genetic diagnosis: an alternative to prenatal diagnosis.
Delhanty JDA Wells D
Expert Rev Mol Diagn, 2:395–399, 2002. -
First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy.
Wells D Escudero T Levy B Hirschhorn K Delhanty JDA Munné S
Fertil Steril, 78:543–549, 2002. -
Preimplantation genetic diagnosis for single gene disorders: experience with five single gene disorders.
Harper JC Wells D Piyamongkol W Abou-Sleiman P Apessos A Ioulianos A Davis M Doshi A Serhal P Ranieri M Rodeck C Delhanty JDA
Prenat Diagn, 22:525–533, 2002. -
Towards a comprehensive analysis of chromosomes and DNA sequences in human embryos.
Wells D
In Advances in Infertility Treatment (Monduzzi Editore, Italy), p459-473. Edited by Filicori M. 2002. -
Comprehensive molecular cytogenetic analysis of the human blastocyst stage.
Fragouli E Lenzi M Ross R Katz-Jaffe M Schoolcraft WB Wells D
Hum Reprod, 23:2596–2608, 2008. -
Birth of a healthy boy after a double factor PGD in a couple carrying a genetic disease and at risk for aneuploidy.
Obradors A Fernandez E Oliver-Bonet M Rius M de la Fuente A Wells D Benet J Navarro J
Hum Reprod, 23:1949–1956, 2008. -
Gene expression profiling of human oocytes at different maturational stages and after in vitro maturation.
Wells D Patrizio P
Am J Obstet Gynecol, 198:455, 2008. -
Preimplantation genetic diagnostic protocols for alpha- and beta-thalassaemias using multiplex fluorescent PCR.
Piyamongkol W Harper JC Delhanty JDA Wells D
Prenat Diagn, 21:753–759, 2001. -
Use of comprehensive chromosomal screening for embryo assessment: microarrays and CGH.
Wells D Alfarawati S Fragouli E
Mol Hum Reprod, 14:703–710, 2008. -
PGD protocols using multiplex fluorescent PCR.
Piyamongkol W Harper CJ Delhanty JDA Wells D
Reprod Biomed Online, 2:212–214, 2001. -
A successful strategy for preimplantation genetic diagnosis of myotonic dystrophy using multiplex fluorescent PCR.
Piyamongkol W Harper JC Sherlock JK Doshi A Serhal PF Delhanty JDA Wells D
Prenat Diagn, 21:223–232, 2001 -
Genetic alterations in gastric cancers from British patients.
Sud R Wells D Talbot IC Delhanty JDA
Cancer Genet Cytogenet, 126:111–119, 2001. -
Preimplantation genetic diagnosis: applications for molecular medicine.
Wells D Delhanty JDA
Trends Mol Med, 7:23–30, 2001 -
Molecular Cytogenetic Comparison of Apocrine Hyperplasia and Apocrine Carcinoma of the Breast.
Jones C Damiani S Wells D Chaggar R Lakhani SR Eusebi V
Am J Pathol, 158:207–214, 2001. -
Diagnosis of single gene defects.
Wells D Sherlock JK
In Preimplantation Genetic Diagnosis, (John Wiley & Sons, UK), p165-190. Edited by Harper J, Delhanty J, Handyside A. 2001. -
Future developments in preimplantation genetic diagnosis.
Harper J Wells D
In Preimplantation Genetic Diagnosis (John Wiley & Sons, UK) p241-262. Edited by Harper J, Delhanty J, Handyside A. 2001. -
Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization.
Wells D Delhanty JDA
Mol Hum Reprod, 6:1055–1062, 2000. -
Comparative Genomic Hybridization Analysis of Myoepithelial Carcinoma of the Breast.
Jones C Foschini MP Chaggar R Lu YJ Wells D Shipley JM Eusebi V Lakhani SR
Lab Investig, 80:831–836, 2000. -
A successful strategy for preimplantation diagnosis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency.
Ioulianos A Wells D Harper JC Delhanty JDA
Prenat Diagn, 20:593–598, 2000. -
Comparative Genomic Hybridization Reveals Extensive Variation Among Different MCF-7 Cell Stocks.
Jones C Payne J Wells D Delhanty JDA Lakhani SR Kortenkamp A
Cancer Genet Cytogenet, 117:153–158, 2000. -
Deletion and duplication of the adenomatous polyposis coli gene resulting from an interchromosomal insertion involving 5 (q22q23.3) in the father.
Hastings RJ Svennevik EC Setterfield B Wells D Delhanty JDA Mackinnon H
J Med Genet, 37:141–145, 2000. -
Molecular methods for selection of the ideal oocyte.
Patrizio P Fragouli E Bianchi V Borini A Wells D
Reprod Biomed Online, 15:346–353, 2007. -
Maternal age-related differential global expression profiles observed in human oocytes.
Steuerwald NM Bermúdez MG Wells D Munné S Cohen J
Reprod Biomed Online, 14:700–708, 2007. -
Single cell diagnosis using comparative genomic hybridization after preliminary DNA amplification still needs more tweaking: too many miscalls.
Fragouli E Delhanty JD Wells D
Fertil Steril, 88:247–248, 2007. -
Removal of 2 cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests that are used to enhance implantation rates.
Cohen J Wells D Munné S
Fertil Steril, 87:496–503, 2007. -
Future genetic and other technologies for assessing embryos.
Wells D
In Handbook of Embryo Evaluation (Taylor and Francis, UK) p287-300. Edited by Cohen, J. and Elder, K. 2007. -
Recent advances and future developments in PGD.
Harper JC Wells D
Prenat Diagn, 19:1193–1199, 1999. -
Detailed chromosomal and molecular genetic analysis of single cells by whole genome amplification and comparative genomic hybridisation.
Wells D Sherlock JK Handyside AH Delhanty JDA
Nucleic Acids Res, 27:1214–1218, 1999. -
Increased susceptibility to maternal aneuploidy demonstrated by comparative genomic hybridization analysis of human MII oocytes and first polar bodies.
Fragouli E Wells D Whalley KM Mills JA Faed MJW Delhanty JDA
Cytogenet Genome Res, 114:30–38, 2006. -
Use of Real-Time Polymerase Chain Reaction to Measure Gene Expression in Single Cells.
Wells D
In Single Cell Diagnostics: Methods and Protocols (Humana Press, USA), p125-134. Edited by Thornhill, A. 2006. -
Preimplantation genetic diagnosis (PGD) of monogenic disease: PCR-based methods for the identification of mutations single cells.
Wells D
PCR: Methods Express (Scion), p159-172. Edited by Hughes, S. 2006. -
Complete cytogenetic investigation of oocytes from a young cancer patient with the use of comparative genomic hybridisation reveals meiotic errors.
Fragouli E Wells D Doshi A Gotts S Harper JC Delhanty JDA
Prenat Diagn, 26:71–76, 2005. -
A successful strategy for Preimplantation Genetic Diagnosis of betathalassemia and simultaneous detection of Down's syndrome using multiplex fluorescent PCR.
Piyamongkol W Vutyavanich T Piyamongkol S Wells D Kunaviktikul C Tongsong T Chaovisitsaree S Saetung R Sanguansermsri T
J Med Assoc Thai, 89:918-27, 2006. -
Strategies for preimplantation genetic diagnosis of single gene disorders by DNA amplification.
Wells D Sherlock JK
Prenat Diagn, 18:1389–1401, 1998. -
Preimplantation genetic diagnosis of cancer: familial adenomatous polyposis coli (FAPC).
Ao A Wells D Handyside AH Winston RML Delhanty JDA
J Assist Reprod Genet, 15:140–144, 1998. -
Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours.
Giarola M Wells D Mondini P Pilotti S Sala P Azzarelli A Bertario L Pierotti MA Delhanty JDA Radice P
Br J Cancer, 78:582–587, 1998. -
Structure and chromosomal mapping of the mouse P2X3 gene.
Souslova V Ravenall S Fox M Wells D Wood JN Akopian AN
Gene, 195:101–111, 1997. -
Single cell detection of beta-thalassaemia mutations using silver stained SSCP analysis: an application for preimplantation diagnosis.
El-Hashemite N Wells D Delhanty J
Mol Hum Reprod, 3:693–698, 1997. -
Genetic diagnosis before implantation.
Delhanty JDA Wells D Harper JC
BMJ, 315:828–829, 1997. -
Detection of haemoglobinopathies and chromosome aneuploidy from minute DNA samples using multiplex PCR.
Sherlock J Cirigliano V Petrou M Wells D Adinolfi M
In Infertility and Assisted Reproductive Technology - From Research to Therapy (Monduzzi Editore, Italy) p203-211. Edited by Ambrosini A, Melis GB, Dalla Pria S, Dessole S. 1997. -
Association of abnormal morphology and altered gene expression in human preimplantation embryos.
Wells D Bermúdez MG Steuerwald N Malter HE Thornhill AR Cohen J
Fertil Steril, 84:343–355, 2005. -
Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation development.
Wells D Bermudez MG Steuerwald N Thornhill AR Walker DL Malter H Delhanty JDA Cohen J
Hum Reprod, 20:1339–1348, 2005. -
Aneuploidy 12 in a Robertsonian (13;14) carrier: Case report.
Gutiérrez-Mateo C Gadea L Benet J Wells D Munné S Navarro J
Hum Reprod, 20:1256–1260, 2005. -
Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation.
Fitzgibbon J Katsanis N Wells D Delhanty J Vallins W Hunt DM
FEBS Lett, 385:185–188, 1996. -
Four novel germline mutations of the APC gene.
Wells D Chapman P Landgrebe JC Tsioupra K Delhanty JDA
Hum Mutat, 8:193–195, 1996. -
APC gene mutation and DNA microsatellite instability in pancreatic cancers of UK origin.
See CG Sud R Wells D Bowles L Ding S Habib N Delhanty JDA
GI Cancer 2, 133-137, 1996. -
Preimplantation genetic diagnosis of beta-thalassaemia.
El-Hashemite N Wells D Delhanty JDA
Lancet, 348:620–621, 1996. -
Rapid detection of rare variants and common polymorphisms in the APC gene by PCR-SSCP for presymptomatic diagnosis and showing allele loss.
Gayther SA Sud R Wells D Tsioupra K Delhanty JD
J Med Genet, 32:568–571, 1995. -
Localisation of the gene encoding diacylglycerol kinase 3 (DAGK3) to human chromosome 3q27-28 and mouse chromosome 16.
Fitzgibbon J Wells D Pilz A Delhanty J Kai M Kanoh H Hunt D
Curr Eye Res, 14:1041–1043, 1995. -
Correlation of loss of heterozygosity with cytogenetic analysis using g-banding and fluorescence in situ hybridization in aneuploid cultures from two human testicular germ-cell tumors.
Al-Jehani RMA Wells D Fox M Parrington JM
Cancer Genet Cytogenet, 85:26–36, 1995. -
Aneuploidy study of human oocytes first polar body comparative genomic hybridization and metaphase II fluorescence in situ hybridization analysis.
Gutiérrez CM Benet J Wells D Colls P Bermudez MG Sánchez-García JF Egozcue J Navarro J Munné S
Hum Reprod, 19:2859-2868, 2004. -
Reliability of comparative genomic hybridization to detect chromosome abnormalities in first polar bodies and metaphase II oocytes.
Gutiérrez-Mateo C Wells D Benet J Sánchez-García JF Bermúdez MG Belil I Egozcue J Munné S Navarro J
Hum Reprod, 19:2118–2125, 2004. -
Advances in preimplantation genetic diagnosis.
Wells D
Eur J Obstet Gynecol Reprod Biol, 115:S97-S101, 2004. -
Expression profiles of individual human oocytes using microarray technology.
Bermúdez MG Wells D Malter H Munné S Cohen J Steuerwald NM
Reprod Biomed Online, 8:325–337, 2004. -
Microarrays for Analysis and Diagnosis of Human Embryos
Wells D Bermudez MG Steuerwald N Chu L Weier U Cohen J Munne S
Fertil Steril, 80:118, 2003. -
Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli.
Gayther SA Wells D SenGupta SB Chapman P Neale K Tsioupra K Delhanty JDA
Hum Mol Genet, 3:53–56, 1994. -
Clinical experience with preimplantation diagnosis of sex by dual fluorescent in situ hybridization.
Griffin DK Handyside AH Harper JC Wilton LJ Atkinson G Soussis I Wells D Kontogianni E Tarin J Geber S
J Assist Reprod Genet, 11:132–143, 1994. -
Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32.
Fitzgibbon J Appukuttan B Gayther S Wells D Delhanty J Hunt D
Hum Genet, 93:79-80, 1994. -
Germline rearrangement of MCC and APC detected by pulsed field gel electrophoresis and fluorescent in situ hybridization.
Gayther SA Wells D Gulati K Chapman P Burn J Delhanty JDA
Ann Hum Genet, 57:169–178, 1993. -
Whole genome amplification/hybridization following ooplasmic aspiration reveals no evidence of genomic DNA disturbance
Malter HE Wells D Bermudez MG Cohen J
Fertil Steril, 80:118, 2003. -
Questions concerning the suitability of comparative genomic hybridization for preimplantation genetic diagnosis.
Munné S Wells D
Fertil Steril, 80:871–872, 2003. -
Detailed investigation of factors influencing amplification efficiency and allele drop-out in single cell PCR: implications for preimplantation genetic diagnosis.
Piyamongkol W Bermudez MG Harper JC Wells D
Mol Hum Reprod, 9:411–420, 2003. -
Single-cell sequencing and mini-sequencing for preimplantation genetic diagnosis.
Bermudez MG Piyamongkol W Tomaz S Dudman E Sherlock JK Wells D
Prenat Diagn, 23:669–677, 2003. -
Cytogenetics in reproductive medicine: The contribution of comparative genomic hybridization (CGH).
Wells D Levy B
BioEssays, 25:289–300, 2003. -
BRCA1/2 Mutation Status Influences Somatic Genetic Progression in Inherited and Sporadic Epithelial Ovarian Cancer Cases.
Ramus SJ Pharoah PD Harrington P Pye C Werness B Bobrow L Ayhan Wells D Fishman A Gore M Dicioccio R Piver MS Whittemore AS Ponder BA Gayther SA
Cancer Research 63:417-423, 2003. -
Whole-genome amplification.
Wells D
In Encyclopaedia of the Human Genome. (Nature Publishing Group, UK). 2003. -
Whole genome amplification and comparative genomic hybridization (CGH).
Wells D Bermudez M
In PCR Technology: Current Innovations, 2nd edition (CRC Press, USA), p349-359. Edited by Weissensteiner T, Griffin HG, Griffin A. 2003. -
Diagnóstico Genético de Pré-implantação: A Visão do Clinico.
Munné S Wells D Sable D
In Reprodução Humana Assistida. (Atheneu, Brazil) p189-198. Edited by Scheffer B, Remohí J, García-Velasco JA, Pellicer A, Simón C. 2003. -
Preimplantation genetic diagnosis: an alternative to prenatal diagnosis.
Delhanty JDA Wells D
Expert Rev Mol Diagn, 2:395–399, 2002. -
First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy.
Wells D Escudero T Levy B Hirschhorn K Delhanty JDA Munné S
Fertil Steril, 78:543–549, 2002. -
Preimplantation genetic diagnosis for single gene disorders: experience with five single gene disorders.
Harper JC Wells D Piyamongkol W Abou-Sleiman P Apessos A Ioulianos A Davis M Doshi A Serhal P Ranieri M Rodeck C Delhanty JDA
Prenat Diagn, 22:525–533, 2002. -
Towards a comprehensive analysis of chromosomes and DNA sequences in human embryos.
Wells D
In Advances in Infertility Treatment (Monduzzi Editore, Italy), p459-473. Edited by Filicori M. 2002. -
Preimplantation genetic diagnostic protocols for alpha- and beta-thalassaemias using multiplex fluorescent PCR.
Piyamongkol W Harper JC Delhanty JDA Wells D
Prenat Diagn, 21:753–759, 2001. -
PGD protocols using multiplex fluorescent PCR.
Piyamongkol W Harper CJ Delhanty JDA Wells D
Reprod Biomed Online, 2:212–214, 2001. -
A successful strategy for preimplantation genetic diagnosis of myotonic dystrophy using multiplex fluorescent PCR.
Piyamongkol W Harper JC Sherlock JK Doshi A Serhal PF Delhanty JDA Wells D
Prenat Diagn, 21:223–232, 2001 -
Genetic alterations in gastric cancers from British patients.
Sud R Wells D Talbot IC Delhanty JDA
Cancer Genet Cytogenet, 126:111–119, 2001. -
Preimplantation genetic diagnosis: applications for molecular medicine.
Wells D Delhanty JDA
Trends Mol Med, 7:23–30, 2001 -
Molecular Cytogenetic Comparison of Apocrine Hyperplasia and Apocrine Carcinoma of the Breast.
Jones C Damiani S Wells D Chaggar R Lakhani SR Eusebi V
Am J Pathol, 158:207–214, 2001. -
Diagnosis of single gene defects.
Wells D Sherlock JK
In Preimplantation Genetic Diagnosis, (John Wiley & Sons, UK), p165-190. Edited by Harper J, Delhanty J, Handyside A. 2001. -
Future developments in preimplantation genetic diagnosis.
Harper J Wells D
In Preimplantation Genetic Diagnosis (John Wiley & Sons, UK) p241-262. Edited by Harper J, Delhanty J, Handyside A. 2001. -
Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization.
Wells D Delhanty JDA
Mol Hum Reprod, 6:1055–1062, 2000. -
Comparative Genomic Hybridization Analysis of Myoepithelial Carcinoma of the Breast.
Jones C Foschini MP Chaggar R Lu YJ Wells D Shipley JM Eusebi V Lakhani SR
Lab Investig, 80:831–836, 2000. -
A successful strategy for preimplantation diagnosis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency.
Ioulianos A Wells D Harper JC Delhanty JDA
Prenat Diagn, 20:593–598, 2000. -
Comparative Genomic Hybridization Reveals Extensive Variation Among Different MCF-7 Cell Stocks.
Jones C Payne J Wells D Delhanty JDA Lakhani SR Kortenkamp A
Cancer Genet Cytogenet, 117:153–158, 2000. -
Deletion and duplication of the adenomatous polyposis coli gene resulting from an interchromosomal insertion involving 5 (q22q23.3) in the father.
Hastings RJ Svennevik EC Setterfield B Wells D Delhanty JDA Mackinnon H
J Med Genet, 37:141–145, 2000. -
Recent advances and future developments in PGD.
Harper JC Wells D
Prenat Diagn, 19:1193–1199, 1999. -
Detailed chromosomal and molecular genetic analysis of single cells by whole genome amplification and comparative genomic hybridisation.
Wells D Sherlock JK Handyside AH Delhanty JDA
Nucleic Acids Res, 27:1214–1218, 1999. -
Strategies for preimplantation genetic diagnosis of single gene disorders by DNA amplification.
Wells D Sherlock JK
Prenat Diagn, 18:1389–1401, 1998. -
Preimplantation genetic diagnosis of cancer: familial adenomatous polyposis coli (FAPC).
Ao A Wells D Handyside AH Winston RML Delhanty JDA
J Assist Reprod Genet, 15:140–144, 1998. -
Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours.
Giarola M Wells D Mondini P Pilotti S Sala P Azzarelli A Bertario L Pierotti MA Delhanty JDA Radice P
Br J Cancer, 78:582–587, 1998. -
Structure and chromosomal mapping of the mouse P2X3 gene.
Souslova V Ravenall S Fox M Wells D Wood JN Akopian AN
Gene, 195:101–111, 1997. -
Single cell detection of beta-thalassaemia mutations using silver stained SSCP analysis: an application for preimplantation diagnosis.
El-Hashemite N Wells D Delhanty J
Mol Hum Reprod, 3:693–698, 1997. -
Genetic diagnosis before implantation.
Delhanty JDA Wells D Harper JC
BMJ, 315:828–829, 1997. -
Detection of haemoglobinopathies and chromosome aneuploidy from minute DNA samples using multiplex PCR.
Sherlock J Cirigliano V Petrou M Wells D Adinolfi M
In Infertility and Assisted Reproductive Technology - From Research to Therapy (Monduzzi Editore, Italy) p203-211. Edited by Ambrosini A, Melis GB, Dalla Pria S, Dessole S. 1997. -
Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation.
Fitzgibbon J Katsanis N Wells D Delhanty J Vallins W Hunt DM
FEBS Lett, 385:185–188, 1996. -
Four novel germline mutations of the APC gene.
Wells D Chapman P Landgrebe JC Tsioupra K Delhanty JDA
Hum Mutat, 8:193–195, 1996. -
APC gene mutation and DNA microsatellite instability in pancreatic cancers of UK origin.
See CG Sud R Wells D Bowles L Ding S Habib N Delhanty JDA
GI Cancer 2, 133-137, 1996. -
Preimplantation genetic diagnosis of beta-thalassaemia.
El-Hashemite N Wells D Delhanty JDA
Lancet, 348:620–621, 1996. -
Rapid detection of rare variants and common polymorphisms in the APC gene by PCR-SSCP for presymptomatic diagnosis and showing allele loss.
Gayther SA Sud R Wells D Tsioupra K Delhanty JD
J Med Genet, 32:568–571, 1995. -
Localisation of the gene encoding diacylglycerol kinase 3 (DAGK3) to human chromosome 3q27-28 and mouse chromosome 16.
Fitzgibbon J Wells D Pilz A Delhanty J Kai M Kanoh H Hunt D
Curr Eye Res, 14:1041–1043, 1995. -
Correlation of loss of heterozygosity with cytogenetic analysis using g-banding and fluorescence in situ hybridization in aneuploid cultures from two human testicular germ-cell tumors.
Al-Jehani RMA Wells D Fox M Parrington JM
Cancer Genet Cytogenet, 85:26–36, 1995. -
Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli.
Gayther SA Wells D SenGupta SB Chapman P Neale K Tsioupra K Delhanty JDA
Hum Mol Genet, 3:53–56, 1994. -
Clinical experience with preimplantation diagnosis of sex by dual fluorescent in situ hybridization.
Griffin DK Handyside AH Harper JC Wilton LJ Atkinson G Soussis I Wells D Kontogianni E Tarin J Geber S
J Assist Reprod Genet, 11:132–143, 1994. -
Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32.
Fitzgibbon J Appukuttan B Gayther S Wells D Delhanty J Hunt D
Hum Genet, 93:79-80, 1994. -
Germline rearrangement of MCC and APC detected by pulsed field gel electrophoresis and fluorescent in situ hybridization.
Gayther SA Wells D Gulati K Chapman P Burn J Delhanty JDA
Ann Hum Genet, 57:169–178, 1993.
- Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid-aneuploid blastocysts.
Fragouli E, Alfarawati S, Spath K, Babariya D, Tarozzi N, Borini A, Wells D. Hum Genet, 136:805–819, 2017. - Mitochondrial DNA quantification as a tool for embryo viability assessment: retrospective analysis of data from single euploid blastocyst transfers.
Ravichandran K, McCaffrey C, Grifo J, Morales A, Perloe M, Munné S, Wells D., Fragouli E.
Hum Reprod, 32:1282-1292, 2017. - Continuing to deliver: the evidence base for pre-implantation genetic screening.
Griffin D, Fishel S, Gordon T, Grifo J, Rechitsky S, Fiorentino F, Treff N, Munné S, Schmutzler A, Vereczkey A, Ghobara T, Nánássy L, Large M, Hamamah S, Anderson R, Gianaroli L, Wells D.
BMJ, 14:356, 2017. - Embryos with morphokinetic abnormalities may develop into euploid blastocysts.
Lagalla C, Tarozzi N, Sciajno R, Wells D, Santo M Di, Nadalini M, Distratis V, Borini A.
Reprod Biomed Online, 34:137–146, 2017. - Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children.
Diot A, Dombi E, Lodge T, Liao C, Morten K, Carver J, Wells D, Child T, Johnston I, Williams S, Poulton J.
Biochem Soc Trans, 44:1091–1100, 2016. - Causes and estimated incidences of sex-chromosome misdiagnosis in preimplantation genetic diagnosis of aneuploidy.
Ravichandran K, Guzman L, Escudero T, Zheng X, Colls P, Jordan A, Cohen J, Wells D, Munné S.
Reprod Biomed Online, 33:550–559, 2016. - The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.
Sermon K, Capalbo A, Cohen J, Coonen E, De Rycke M, De Vos A, Delhanty J, Fiorentino F, Gleicher N, Griesinger G, Grifo J, Handyside A, Harper J, Kokkali G, Mastenbroek S, Meldrum D, Meseguer M, Montag M, Munné S, Rienzi L, Rubio C, Scott K, Scott R, Simon C, Swain J, Treff N, Ubaldi F, Vassena R, Vermeesch J, Verpoest W, Wells D, Geraedts J.
Mol Hum Reprod, 22:845–857, 2016. - Why do euploid embryos miscarry? A case-control study comparing the rate of aneuploidy within presumed euploid embryos that resulted in miscarriage or live birth using next-generation sequencing.
Maxwell SM, Colls P, Hodes-Wertz B, McCulloh DH, McCaffrey C, Wells D, Munné S, Grifo J.
Fertil Steril, 106:1414-1419, 2016. - Investigation of sperm telomere length as a potential marker of paternal genome integrity and semen quality.
Cariati F, Jaroudi S, Alfarawati S, Raberi A, Alviggi C, Pivonello R, Wells D. Reprod Biomed Online, 33:404–411, 2016. - Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease.
Hyslop LA, Blakeley P, Craven L, Richardson J, Fogarty NM, Fragouli E, Lamb M, Wamaitha SE, Prathalingam N, Zhang Q, O'Keefe H, Takeda Y, Arizzi L, Alfarawati S, Tuppen HA, Irving L, Kalleas D, Choudhary M, Wells D, Murdoch AP, Turnbull DM, Niakan KK, Herbert M.
Nature, 534:383–386, 2016. - Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.
Enciso M, Sarasa J, Xanthopoulou L, Bristow S, Bowles M, Fragouli E, Delhanty J, Wells D.
Hum Genet, 135:555–568, 2016. - Preimplantation genetic diagnosis: an overview and recent advances.
Ben-Nagi J, Serhal P, SenGupta S, Doye K, Wells D.
Obstet Gynaecol, 18:99–106, 2016. - Current controversies in prenatal diagnosis 4: preimplantation genetic screening should be routinely offered to all preimplantation genetic diagnosis cases.
Harper J, Wells D, Simpson JL.
Prenat Diagn, 36:25–28, 2016. - Mosaicism: “survival of the fittest” versus “no embryo left behind”.
Munné S, Grifo J, Wells D.
Fertil Steril, 105:1146–1149, 2016. - Preimplantation genetic diagnosis for infertility.
Wells D, Lewin J.
In Textbook of Assisted Reproductive technologies, 5th Edition (Informa Healthcare, UK), p346-353. Edited by Gardner D, Weissman A, Howles C, Shoham Z. 2016. - Karyomapping identifies second polar body DNA persisting to the blastocyst stage: implications for embryo biopsy.
Ottolini CS, Rogers S, Sage K, Summers MC, Capalbo A, Griffin DK, Sarasa J, Wells D, Handyside AH.
Reprod Biomed Online, 31:776–782, 2015. - Karyomapping allows preimplantation genetic diagnosis of a de-novo deletion undetectable using conventional PGD technology.
Giménez C, Sarasa J, Arjona C, Vilamajó E, Martinez-Pasarell O, Wheeler K, Valls G, Garcia-Guixé E, Wells D.
Reprod Biomed Online, 31:770–775, 2015. - Characterization and quantification of proteins secreted by single human embryos prior to implantation.
Poli M, Ori A, Child T, Jaroudi S, Spath K, Beck M, Wells D.
EMBO Mol Med, 7:1465–1479, 2015. - Validation of next-generation sequencing for comprehensive chromosome screening of embryos.
Kung A, Munné S, Bankowski B, Coates A, Wells D.
Reprod Biomed Online, 31:760–769, 2015. - Mitochondrial DNA Assessment to Determine Oocyte and Embryo Viability.
Wells D, Fragouli E.
Semin Reprod Med, 33:401–409, 2015. - Live births following Karyomapping of human blastocysts: experience from clinical application of the method.
Konstantinidis M, Prates R, Goodall N, Fischer J, Tecson V, Lemma T, Chua B, Jordan A, Armenti E, Wells D, Munné S.
Reprod Biomed Online, 31:394–403, 2015. - Deep impact: sequencing embryo biopsy specimens at increasing depth.
Spath K, Wells D.
Reprod Biomed Online, 31:1–3, 2015. - Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential.
Fragouli E, Spath K, Alfarawati S, Kaper F, Craig A, Michel CE, Kokocinski F, Cohen J, Munné S, Wells D.
PLOS Genet, 11, 2015. - Karyomapping - a comprehensive means of simultaneous monogenic and cytogenetic PGD: comparison with standard approaches in real time for Marfan syndrome.
Thornhill AR, Handyside AH, Ottolini C, Natesan SA, Taylor J, Sage K, Harton G, Cliffe K, Affara N, Konstantinidis M, Wells D, Griffin DK.
J Assist Reprod Genet, 32:347–356, 2015. - Routine use of next-generation sequencing for preimplantation genetic diagnosis of blastomeres obtained from embryos on day 3 in fresh in~vitro fertilization cycles.
Łukaszuk K, Pukszta S, Wells D, Cybulska C, Liss J, Płóciennik Ł, Kuczyński W, Zabielska J.
Fertil Steril, 103:1031–1036, 2015. - Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform.
Konstantinidis M, Alfarawati S, Hurd D, Paolucci M, Shovelton J, Fragouli E, Wells D.
Fertil Steril, 102:1385–1392, 2014. - Genome-wide karyomapping accurately identifies the inheritance of single-gene defects in human preimplantation embryos in vitro.
Natesan SA, Bladon AJ, Coskun S, Qubbaj W, Prates R, Munné S, Coonen E, Dreesen JC, Stevens SJ, Paulussen AD, Stock-Myer SE, Wilton LJ, Jaroudi S, Wells D, Brown AP, Handyside AH.
Genet Med,16:838–845, 2014. - Live birth after PGD with confirmation by a comprehensive approach (karyomapping) for simultaneous detection of monogenic and chromosomal disorders.
Natesan SA, Handyside AH, Thornhill AR, Ottolini CS, Sage K, Summers MC, Konstantinidis M, Wells D, Griffin DK.
Reprod Biomed Online, 29:600–605, 2014. - Human embryonic aneuploidy.
Fragouli E, Wells D.
Encyclopedia of Life Sciences, Online, 2014. - Clinical utilization of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation.
Wells D, Kaur K, Grifo J, Glassner M, Taylor JC, Fragouli E, Munné S.
J Med Genet, 51:553–562, 2014. - Telomere length and aneuploidy: clinical and biological insights into human preimplantation embryos.
Simpson JL, Wells D.
Reprod Biomed Online, 28:531–532, 2014. - Next-generation sequencing: the dawn of a new era for preimplantation genetic diagnostics.
Wells D.
Fertil Steril, 101:1250–1251, 2014. - Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature.
Fauser B, Devroey P, Diedrich K, Balaban B, Bonduelle M, de Waal HAD, Estella C, Ezcurra D, Geraedts JP, Howles CM Lerner-Geva L, Serna J, Wells D.
Reprod Biomed Online, 28:162–182, 2014. - Diminished Effect of Maternal Age on Implantation After Preimplantation Genetic Diagnosis With Array Comparative Genomic Hybridization.
Harton GL, Munné S, Surrey M, Grifo J, Kaplan B, McCulloh DH, Griffin DK, Wells D, PGD Practitioners Group.
Obstet Gynecol Surv, 69:744–745, 2014. - Morphological and cytogenetic assessment of cleavage and blastocyst stage embryos.
Fragouli E, Alfarawati S, Spath K, Wells D.
Mol Hum Reprod, 20:117–126, 2013. - The transcriptome of follicular cells: biological insights and clinical implications for the treatment of infertility.
Fragouli E, Lalioti MD, Wells D.
Hum Reprod Update, 20:1–11, 2013. - The origin and impact of embryonic aneuploidy.
Fragouli E, Alfarawati S, Spath K, Jaroudi S, Sarasa J, Enciso M, Wells D. Hum Genet, 132:1001–1013, 2013. - Questions about the accuracy of polar body analysis for preimplantation genetic screening.
Fragouli E, Wells D.
Hum Reprod, 28:1731–1732, 2013. - Genomic DNA in human blastocoele fluid.
Palini S, Galluzzi L, Stefani S De, Bianchi M, Wells D, Magnani M, Bulletti C. Reprod Biomed Online, 26:603–610, 2013. - Increased numbers of DNA-damaged spermatozoa in samples presenting an elevated rate of numerical chromosome abnormalities.
Enciso M, Alfarawati S, Wells D.
Hum Reprod, 28:1707–1715, 2013. - Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization.
Harton GL, Munné S, Surrey M, Grifo J, Kaplan B, McCulloh DH, Griffin DK, Wells D, PGD Practitioners Group.
Fertil Steril, 100:1695–1703, 2013. - Alterations in the gene expression of aneuploid oocytes and associated cumulus cells.
Wells D.
Biology and Pathology of the Oocyte, Role in Fertility and Reproductive Medicine (Cambridge University Press), p346-352. Edited by Eichenlaub-Ritter U, Gosden R, Trounson A. 2013. - Gamete and embryo assessment in assisted reproduction: emerging technologies
Editor: Gardner D, Sakkas D, Seli E, Wells D.
(Springer Scientific). 2013. - High-density SNP arrays and next generation sequencing for pre-implantation genetic diagnosis.
Handyside A, Wells, D.
In Gamete and embryo assessment in assisted reproduction: emerging technologies (Springer Scientific), p135-146. Edited by Gardner, D., Sakkas, D., Seli, E. and Wells, D. 2013. - Use of Comparative Genomic Hybridization (CGH) and microarray-CGH for preimplantation genetic screening.
Wilton L, Wells D.
In Gamete and embryo assessment in assisted reproduction: emerging technologies (Springer Scientific), p147-156. Edited by Gardner D, Sakkas D, Seli E, Wells, D. 2013. - Transcriptomic analysis of cumulus and granulosa cells as a marker of embryo viability.
Fragouli E, Wells D.
Gamete and embryo assessment in assisted reproduction: emerging technologies. p185-192. Edited by Gardner D, Sakkas D, Seli E, Wells D. (Springer Scientific). 2013. - The Textbook of Clinical Embryology
Editor: Coward and Wells (2013)
(Cambridge University Press, UK). 2013. - Preimplantation genetic screening.
Wells D.
The Textbook of Clinical Embryology (Cambridge University Press, UK). p357-363. Edited by Coward K. and Wells D. 2013. - Preimplantation genetic diagnosis.
Wells D, Fragouli E.
The Textbook of Clinical Embryology (Cambridge University Press, UK). p346-356. Edited by Coward K. and Wells D. 2013. - Successful Live Birth following Preimplantation Genetic Diagnosis for Phenylketonuria in Day 3 Embryos by Specific Mutation Analysis and Elective Single Embryo Transfer.
Lavery S, Abdo D, Kotrotsou M, Trew G, Konstantinidis M, Wells D.
JIMD Reports, 7:49–54, 2012. - Microarray-CGH for the Assessment of Aneuploidy in Human Polar Bodies and Oocytes.
Jaroudi S, Wells D.
Methods in Molecular Biology, 957:267–283, 2012. - Embryos of Robertsonian Translocation Carriers Exhibit a Mitotic Interchromosomal Effect That Enhances Genetic Instability during Early Development.
Alfarawati S, Fragouli E, Colls P, Wells D.
PLoS Genet, 8, 2012. - Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCζ) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells.
Kashir J, Konstantinidis M, Jones C, Heindryckx B, Sutter P De, Parrington J, Wells D, Coward K.
Fertil Steril, 98:423–431, 2012. - A method for semi-automatic grading of human blastocyst microscope images.
Filho ES, Noble JA, Poli M, Griffiths T, Emerson G, Wells D.
Hum Reprod, 27:2641–2648, 2012. - Development of a novel synthetic oligopeptide for the detection of DNA damage in human spermatozoa.
Enciso M, Pieczenik G, Cohen J, Wells D.
Hum Reprod, 27:2254–2266, 2012. - Alteration of gene expression in human cumulus cells as a potential indicator of oocyte aneuploidy.
Fragouli E, Wells D, Iager AE, Kayisli UA, Patrizio P.
Hum Reprod, 27:2559–2568, 2012. - Aneuploidy Screening for Embryo Selection.
Fragouli E, Wells D.
Semin Reprod Med, 30:289–301, 2012. - Biomolecules of Human Female Fertility - Potential Therapeutic Targets for Pharmaceutical Design.
Huang Z, Fragouli E, Wells D.
Curr Pharm Des, 18:310–324, 2012. - Transcriptomic analysis of follicular cells provides information on the chromosomal status and competence of unfertilized oocytes.
Fragouli E, Wells D.
Expert Rev Mol Diagn, 12:1–4, 2012. - Intra-age, intercenter, and intercycle differences in chromosome abnormalities in oocytes.
Munné S, Held KR, Magli CM, Ata B, Wells D, Fragouli E, Baukloh v, Fischer R, Gianaroli L.
Fertil Steril, 97:935–942, 2012. - PGD and aneuploidy screening for 24 chromosomes by genome-wide SNP analysis: a responsible path towards greater utility.
Bisignano A, Wells D, Harton G, Munné S.
Reprod Biomed Online, 24:4–5, 2012. - Microarray-CGH for the assessment of aneuploidy in human polar bodies and oocytes.
Jaroudi S, Wells D.
Mammalian Oocyte Regulation (Humana Press). p267-284. Edited by Homer, H. 2012. - Preimplantation genetic diagnosis (PGD), preimplantation genetic screening (PGS) and the transfer of in vitro fertilized embryos.
Wells D.
In Brenner’s Online Encyclopedia of Genetics (Elsevier). Edited by Maloy S, Hughes K. 2012. - Cumulus cell gene expression in assessment of oocyte quality.
Wells D.
In Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices (Springer, NY, USA), p127-132. Edited by Agarwal, A., Varghese, A., Nagy, Z. 2012. - A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility.
Kashir J, Konstantinidis M, Jones C, Lemmon B, Lee HC, Hamer R, Heindryckx B, Deane CM, De Sutter P, Fissore RA, Parrington J, Wells D, Coward K.
Hum Reprod, 27:222–231, 2011. - The cytogenetics of polar bodies: insights into female meiosis and the diagnosis of aneuploidy.
Fragouli E, Alfarawati S, Goodall N, Sanchez-Garcia JF, Colls P, Wells D.
Mol Hum Reprod, 17:286–295, 2011. - Polar bodies: their biological mystery and clinical meaning.
Wells D, Hillier SG.
Mol Hum Reprod, 17:273–274, 2011. - First births after preimplantation genetic diagnosis of structural chromosome abnormalities using comparative genomic hybridization and microarray analysis.
Alfarawati S, Fragouli E, Colls P, Wells D.
Hum Reprod, 26:1560–1574, 2011. - Chromosome Abnormalities in the Human Oocyte.
Fragouli E, Wells D, Delhanty J.
Cytogenet Genome Res, 133:107–118, 2011. - PGD and aneuploidy screening for 24 chromosomes: advantages and disadvantages of competing platforms.
Bisignano A, Wells D, Harton G, Munné S.
Reprod Biomed Online, 23:677–685, 2011. - Aneuploidy in the Human Blastocyst.
Fragouli E, Wells D.
Cytogenet Genome Res, 133:149–159, 2011. - Reproductive medicine and beyond.
Wells D.
Expert Rev Obstet Gynecol, 6:371–376, 2011. - A skewed sex ratio following blastocyst culture is a consequence of embryo grading systems that prioritise male embryos for transfer.
Wells D, Alfarawati S, Fragouli E.
BJOG An Int J Obstet Gynaecol, 118:381, 2011. - How to improve IVF success rates and increase access to treatment: back to basics or more technology?
Wells D.
Expert Rev Obstet Gynecol, 6:19–22, 2011. - The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender.
Alfarawati S, Fragouli E, Colls P, Stevens J, Gutiérrez-Mateo C, Schoolcraft WB, Katz-Jaffe MG, Wells D.
Fertil Steril, 95:520–524, 2011. - Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos.
Gutiérrez-Mateo C, Colls P, Sánchez-Garcia J, Escudero T, Prates R, Ketterson K, Wells D, Munné S.
Fertil Steril, 95:953–958, 2011. - Therapeutic treatments of mtDNA diseases at the earliest stages of human development.
Chiaratti MR, Meirelles FV, Wells D, Poulton J.
Mitochondrion, 11:820–828, 2011. - Molecular aspects of follicular development.
Huang Z, Wells D.
In Principles & Practice of Fertility Preservation (Cambridge University Press, UK), p114-128. Edited by Donnez J, Kim S. 2011. - Preimplantation genetic diagnosis for infertility.
Wells D, Fragouli E.
Textbook of Assisted Reproductive technologies, 4th Edition (Informa Healthcare, UK), p346-353. Edited by Gardner D, Weissman A, Howles C, Shoham Z. 2011. - Cytogenetic analysis of human blastocysts with the use of FISH, CGH and aCGH: scientific data and technical evaluation.
Fragouli E, Alfarawati S, Daphnis D, Goodall N, Mania A, Griffiths T, Gordon T, Wells D.
Hum Reprod, 26:480–490, 2010. - The human oocyte and cumulus cells relationship: new insights from the cumulus cell transcriptome.
Huang Z, Wells D.
MHR Basic Sci Reprod Med, 16:715–725, 2010. - Toward a method for automatic grading of microscope human embryo images.
Filho ES, Noble JA, Wells D.
IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 2010. - A Review on Automatic Analysis of Human Embryo Microscope Images.
Filho E, Noble JA, Wells D.
Open Biomed Eng J, 4:170–177, 2010. - Clinical application of comprehensive chromosomal screening at the blastocyst stage.
Schoolcraft WB, Fragouli E, Stevens J, Munne S, Katz-Jaffe MG, Wells D. Fertil Steril, 94:1700–1706, 2010. - Transmission of Mitochondrial DNA Diseases and Ways to Prevent Them.
Poulton J, Chiaratti MR, Meirelles FV, Kennedy S, Wells D, Holt IJ.
PLoS Genet, 6, 2010. - Towards a non-invasive assessment of oocyte competence: gene expression approaches.
Wells D, Fragouli E.
Journal of Reproductive Medicine and Endocrinology, 7:233-235, 2010. - Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes.
Munné S, Wells D, Cohen J.
Fertil Steril, 94:408–430, 2010. - Clinical application of comprehensive chromosomal screening at the blastocyst stage.
Schoolcraft WB, Fragouli E, Stevens J, Munné S, Katz-Jaffe MG, Wells D. Revista Iberoamericana de Fertilidad y Reproduccion Humana, 27:447-457, 2010. - Microarrays and CGH for PGD of chromosome abnormalities and gene defects.
Munné S, Harton G, Held K, Wells D.
Journal of Reproductive Medicine and Endocrinology, 7:236-239, 2010. - Embryo aneuploidy and the role of morphological and genetic screening.
Wells D.
Reprod Biomed Online, 21:274–277, 2010. - Transcriptomic profiling of human oocytes: association of meiotic aneuploidy and altered oocyte gene expression.
Fragouli E, Bianchi V, Patrizio P, Obradors A, Huang Z, Borini A, Delhanty J, Wells D.
Mol Hum Reprod, 16:570–582, 2010. - Comprehensive chromosome screening of polar bodies and blastocysts from couples experiencing repeated implantation failure.
Fragouli E, Katz-Jaffe M, Alfarawati S, Stevens J, Colls P, Goodall N, Tormasi S, Gutierrez-Mateo C, Prates R, Schoolcraft WB, Munné S, Wells D.
Fertil Steril, 94:875–887, 2010. - Improved detection of aneuploid blastocysts using a new 12-chromosome FISH test.
Munné S, Fragouli E, Colls P, Katz-Jaffe MG, Schoolcraft WB, Wells D. Reprod Biomed Online, 20:92–97, 2010. - Preventing transmission of maternally inherited mitochondrial DNA diseases.
Poulton J, Kennedy S, Oakeshott P, Wells D.
BMJ, 338:94, 2009. - Comparative genomic hybridization of oocytes and first polar bodies from young donors.
Fragouli E, Escalona A, Gutiérrez-Mateo C, Tormasi S, Alfarawati S, Sepulveda S, Wells D, Munné S.
Reprod Biomed Online, 19:228–237, 2009. - The role of preimplantation genetic diagnosis in diagnosing embryo aneuploidy.
Munné S, Howles CM, Wells D.
Curr Opin Obstet Gynecol, 21:442–449, 2009. - Preimplantation genetic diagnosis of single-gene disorders: experience with more than 200 cycles conducted by a reference laboratory in the United States.
Gutiérrez-Mateo C, Sánchez-Garcia JF, Fischer J, Tormasi S, Cohen J, Munné S, Wells D.
Fertil Steril, 92:1544–1556, 2009. - Preimplantation genetics.
Delhanty JDA, Wells D.
In Preimplantation Genetic Diagnosis (Cambridge University Press, UK), p137-150. Edited by Harper, J. 2009. - Use of comprehensive chromosomal screening for embryo assessment: microarrays and CGH.
Wells D, Alfarawati S, Fragouli E.
Mol Hum Reprod, 14:703–710, 2008. - Comprehensive molecular cytogenetic analysis of the human blastocyst stage.
Fragouli E, Lenzi M, Ross R, Katz-Jaffe M, Schoolcraft WB, Wells D.
Hum Reprod, 23:2596–2608, 2008. - Birth of a healthy boy after a double factor PGD in a couple carrying a genetic disease and at risk for aneuploidy.
Obradors A, Fernandez E, Oliver-Bonet M, Rius M, de la Fuente A, Wells D, Benet J, Navarro J.
Hum Reprod, 23:1949–1956, 2008. - Gene expression profiling of human oocytes at different maturational stages and after in vitro maturation.
Wells D, Patrizio P.
Am J Obstet Gynecol, 198:455, 2008. - Molecular methods for selection of the ideal oocyte.
Patrizio P, Fragouli E, Bianchi V, Borini A, Wells D.
Reprod Biomed Online, 15:346–353, 2007. - Maternal age-related differential global expression profiles observed in human oocytes.
Steuerwald NM, Bermúdez MG, Wells D, Munné S, Cohen J.
Reprod Biomed Online, 14:700–708, 2007. - Single cell diagnosis using comparative genomic hybridization after preliminary DNA amplification still needs more tweaking: too many miscalls.
Fragouli E, Delhanty JD, Wells D.
Fertil Steril, 88:247–248, 2007. - Removal of 2 cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests that are used to enhance implantation rates.
Cohen J, Wells D, Munné S.
Fertil Steril, 87:496–503, 2007. - Future genetic and other technologies for assessing embryos.
Wells, D.
In Handbook of Embryo Evaluation (Taylor and Francis, UK) p287-300. Edited by Cohen, J. and Elder, K. 2007. - Comparative genomic hybridization analysis of human oocytes and polar bodies.
Fragouli E, Wells D, Thornhill A, Serhal P, Faed MJ, Harper JC, Delhanty JD. Hum Reprod, 21:2319–2328, 2006. - Increased susceptibility to maternal aneuploidy demonstrated by comparative genomic hybridization analysis of human MII oocytes and first polar bodies.
Fragouli E, Wells D, Whalley KM, Mills JA, Faed MJW, Delhanty JDA.
Cytogenet Genome Res, 114:30–38, 2006. - Use of Real-Time Polymerase Chain Reaction to Measure Gene Expression in Single Cells.
Wells, D.
In Single Cell Diagnostics: Methods and Protocols (Humana Press, USA), p125-134. Edited by Thornhill, A. 2006. - Preimplantation genetic diagnosis (PGD) of monogenic disease: PCR-based methods for the identification of mutations single cells.
Wells D.
PCR: Methods Express (Scion), p159-172. Edited by Hughes, S. 2006. - Complete cytogenetic investigation of oocytes from a young cancer patient with the use of comparative genomic hybridisation reveals meiotic errors.
Fragouli E, Wells D, Doshi A, Gotts S, Harper JC, Delhanty JDA.
Prenat Diagn, 26:71–76, 2005. - A successful strategy for Preimplantation Genetic Diagnosis of beta-thalassemia and simultaneous detection of Down's syndrome using multiplex fluorescent PCR.
Piyamongkol W, Vutyavanich T, Piyamongkol S, Wells D, Kunaviktikul C, Tongsong T, Chaovisitsaree S, Saetung R, Sanguansermsri T.
J Med Assoc Thai, 89:918-27, 2006. - Association of abnormal morphology and altered gene expression in human preimplantation embryos.
Wells D, Bermúdez MG, Steuerwald N, Malter HE, Thornhill AR, Cohen J. Fertil Steril, 84:343–355, 2005. - Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation development.
Wells D, Bermudez MG, Steuerwald N, Thornhill AR, Walker DL, Malter H, Delhanty JDA, Cohen J.
Hum Reprod, 20:1339–1348, 2005. - Aneuploidy 12 in a Robertsonian (13;14) carrier: Case report.
Gutiérrez-Mateo C, Gadea L, Benet J, Wells D, Munné S, Navarro J.
Hum Reprod, 20:1256–1260, 2005. - Aneuploidy study of human oocytes first polar body comparative genomic hybridization and metaphase II fluorescence in situ hybridization analysis.
Gutiérrez, C.M., Benet, J., Wells, D., Colls, P., Bermudez, M.G., Sánchez-García, J.F., Egozcue, J., Navarro, J., Munné, S.
Hum Reprod, 19:2859-2868, 2004. - Reliability of comparative genomic hybridization to detect chromosome abnormalities in first polar bodies and metaphase II oocytes.
Gutiérrez-Mateo C, Wells D, Benet J, Sánchez-García JF, Bermúdez MG, Belil I, Egozcue J, Munné S, Navarro J.
Hum Reprod, 19:2118–2125, 2004. - Advances in preimplantation genetic diagnosis.
Wells D.
Eur J Obstet Gynecol Reprod Biol, 115:S97-S101, 2004. - Expression profiles of individual human oocytes using microarray technology.
Bermúdez MG, Wells D, Malter H, Munné S, Cohen J, Steuerwald NM. Reprod Biomed Online, 8:325–337, 2004. - Microarrays for Analysis and Diagnosis of Human Embryos.
Wells D, Bermudez MG, Steuerwald N, Chu L, Weier U, Cohen J, Munne S.
In Recent Advances in Prenatal Genetic Diagnosis (Medimond), p9-17. Edited by Papp Z, Rodeck, C. 2004. - Whole genome amplification/hybridization following ooplasmic aspiration reveals no evidence of genomic DNA disturbance.
Malter HE, Wells D, Bermudez MG, Cohen J.
Fertil Steril, 80:118, 2003. - Questions concerning the suitability of comparative genomic hybridization for preimplantation genetic diagnosis.
Munné S, Wells D.
Fertil Steril, 80:871–872, 2003. - Detailed investigation of factors influencing amplification efficiency and allele drop-out in single cell PCR: implications for preimplantation genetic diagnosis.
Piyamongkol W, Bermudez MG, Harper JC, Wells D.
Mol Hum Reprod, 9:411–420, 2003. - Single-cell sequencing and mini-sequencing for preimplantation genetic diagnosis.
Bermudez MG, Piyamongkol W, Tomaz S, Dudman E, Sherlock JK, Wells D. Prenat Diagn, 23:669–677, 2003. - Cytogenetics in reproductive medicine: The contribution of comparative genomic hybridization (CGH).
Wells D, Levy B.
BioEssays, 25:289–300, 2003. - BRCA1/2 Mutation Status Influences Somatic Genetic Progression in Inherited and Sporadic Epithelial Ovarian Cancer Cases.
Ramus SJ, Pharoah PD, Harrington P, Pye C, Werness B, Bobrow L, Ayhan, Wells D, Fishman A, Gore M, Dicioccio R, Piver MS, Whittemore AS, Ponder BA, Gayther SA.
Cancer Research 63:417-423, 2003. - Whole-genome amplification.
Wells D.
In Encyclopaedia of the Human Genome. (Nature Publishing Group, UK). 2003. - Whole genome amplification and comparative genomic hybridization (CGH).
Wells D, Bermudez M.
In PCR Technology: Current Innovations, 2nd edition (CRC Press, USA), p349-359. Edited by Weissensteiner T, Griffin HG, Griffin A. 2003. - Diagnóstico Genético de Pré-implantação: A Visão do Clinico.
Munné S, Wells D, Sable D.
In Reprodução Humana Assistida. (Atheneu, Brazil) p189-198. Edited by Scheffer B, Remohi J, Garcia-Velasco J, Pellicer A, Simón C. 2003. - Preimplantation genetic diagnosis: an alternative to prenatal diagnosis.
Delhanty JDA, Wells D.
Expert Rev Mol Diagn, 2:395–399, 2002. - First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy.
Wells D, Escudero T, Levy B, Hirschhorn K, Delhanty JDA, Munné S.
Fertil Steril, 78:543–549, 2002. - Preimplantation genetic diagnosis for single gene disorders: experience with five single gene disorders.
Harper JC, Wells D, Piyamongkol W, Abou-Sleiman P, Apessos A, Ioulianos A, Davis M, Doshi A, Serhal P, Ranieri M, Rodeck C, Delhanty JDA.
Prenat Diagn, 22:525–533, 2002. - Preimplantation genetic diagnosis.
Munné S, Wells D.
Curr Opin Obstet Gynecol, 14:239–244, 2002. - Towards a comprehensive analysis of chromosomes and DNA sequences in human embryos.
Wells D.
In Advances in Infertility Treatment (Monduzzi Editore, Italy), p459-473. Edited by Filicori M. 2002. - Preimplantation genetic diagnostic protocols for alpha- and beta-thalassaemias using multiplex fluorescent PCR.
Piyamongkol W, Harper JC, Delhanty JDA, Wells D.
Prenat Diagn, 21:753–759, 2001. - PGD protocols using multiplex fluorescent PCR.
Piyamongkol W, Harper CJ, Delhanty JDA, Wells D.
Reprod Biomed Online, 2:212–214, 2001. - A successful strategy for preimplantation genetic diagnosis of myotonic dystrophy using multiplex fluorescent PCR.
Piyamongkol W, Harper JC, Sherlock JK, Doshi A, Serhal PF, Delhanty JDA, Wells D.
Prenat Diagn, 21:223–232, 2001. - Genetic alterations in gastric cancers from British patients.
Sud R, Wells D, Talbot IC, Delhanty JDA.
Cancer Genet Cytogenet, 126:111–119, 2001. - Preimplantation genetic diagnosis: applications for molecular medicine.
Wells D, Delhanty JDA.
Trends Mol Med, 7:23–30, 2001. - Molecular Cytogenetic Comparison of Apocrine Hyperplasia and Apocrine Carcinoma of the Breast.
Jones C, Damiani S, Wells D, Chaggar R, Lakhani SR, Eusebi V.
Am J Pathol, 158:207–214, 2001. - Diagnosis of single gene defects.
Wells D, Sherlock, JK.
In Preimplantation Genetic Diagnosis, (John Wiley & Sons, UK), p165-190. Edited by Harper J, Delhanty J, Handyside A. 2001. - Future developments in preimplantation genetic diagnosis.
Harper J, Wells D.
In Preimplantation Genetic Diagnosis (John Wiley & Sons, UK) p241-262. Edited by Harper J, Delhanty J, Handyside A. 2001. - Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization.
Wells D, Delhanty JDA.
Mol Hum Reprod, 6:1055–1062, 2000. - Comparative Genomic Hybridization Analysis of Myoepithelial Carcinoma of the Breast.
Jones C, Foschini MP, Chaggar R, Lu YJ, Wells D, Shipley JM, Eusebi V, Lakhani SR.
Lab Investig, 80:831–836, 2000. - A successful strategy for preimplantation diagnosis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency.
Ioulianos A, Wells D, Harper JC, Delhanty JDA.
Prenat Diagn, 20:593–598, 2000. - Comparative Genomic Hybridization Reveals Extensive Variation Among Different MCF-7 Cell Stocks.
Jones C, Payne J, Wells D, Delhanty JDA, Lakhani SR, Kortenkamp A. Cancer Genet Cytogenet, 117:153–158, 2000. - Deletion and duplication of the adenomatous polyposis coli gene resulting from an interchromosomal insertion involving 5 (q22q23.3) in the father.
Hastings RJ, Svennevik EC, Setterfield B, Wells D, Delhanty JDA, Mackinnon H.
J Med Genet, 37:141–145, 2000. - Preimplantation genetic diagnosis.
Wells D.
Invited editorial. Prenat Diagn, 19:1190–1192, 1999. - Recent advances and future developments in PGD.
Harper JC, Wells D.
Prenat Diagn, 19:1193–1199, 1999. - Detailed chromosomal and molecular genetic analysis of single cells by whole genome amplification and comparative genomic hybridisation.
Wells D, Sherlock JK, Handyside AH, Delhanty JDA.
Nucleic Acids Res, 27:1214–1218, 1999. - Strategies for preimplantation genetic diagnosis of single gene disorders by DNA amplification.
Wells D, Sherlock JK.
Prenat Diagn, 18:1389–1401, 1998. - Preimplantation genetic diagnosis of cancer: familial adenomatous polyposis coli (FAPC).
Ao A, Wells D, Handyside AH, Winston RML, Delhanty JDA.
J Assist Reprod Genet, 15:140–144, 1998. - Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours.
Giarola M, Wells D, Mondini P, Pilotti S, Sala P, Azzarelli A, Bertario L, Pierotti MA, Delhanty JDA, Radice P.
Br J Cancer, 78:582–587, 1998. - Structure and chromosomal mapping of the mouse P2X3 gene.
Souslova V, Ravenall S, Fox M, Wells D, Wood JN, Akopian AN.
Gene, 195:101–111, 1997. - Single cell detection of beta-thalassaemia mutations using silver stained SSCP analysis: an application for preimplantation diagnosis.
El-Hashemite N, Wells D, Delhanty J.
Mol Hum Reprod, 3:693–698, 1997. - Genetic diagnosis before implantation.
Delhanty JDA, Wells D, Harper JC.
BMJ, 315:828–829, 1997. - Detection of haemoglobinopathies and chromosome aneuploidy from minute DNA samples using multiplex PCR.
Sherlock J, Cirigliano V, Petrou M, Wells D, Adinolfi M.
In Infertility and Assisted Reproductive Technology - From Research to Therapy (Monduzzi Editore, Italy) p203-211. Edited by Ambrosini A, Melis GB, Dalla Pria S, Dessole S. 1997. - Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation.
Fitzgibbon J, Katsanis N, Wells D, Delhanty J, Vallins W, Hunt DM.
FEBS Lett, 385:185–188, 1996. - Four novel germline mutations of the APC gene.
Wells D, Chapman P, Landgrebe JC, Tsioupra K, Delhanty JDA.
Hum Mutat, 8:193–195, 1996. - APC gene mutation and DNA microsatellite instability in pancreatic cancers of UK origin.
See CG, Sud R, Wells D, Bowles L, Ding S, Habib N, Delhanty JDA.
GI Cancer 2, 133-137, 1996. - Preimplantation genetic diagnosis of beta-thalassaemia.
El-Hashemite N, Wells D, Delhanty JDA.
Lancet, 348:620–621, 1996. - Rapid detection of rare variants and common polymorphisms in the APC gene by PCR-SSCP for presymptomatic diagnosis and showing allele loss.
Gayther SA, Sud R, Wells D, Tsioupra K, Delhanty JD.
J Med Genet, 32:568–571, 1995. - Localisation of the gene encoding diacylglycerol kinase 3 (DAGK3) to human chromosome 3q27-28 and mouse chromosome 16.
Fitzgibbon J, Wells D, Pilz A, Delhanty J, Kai M, Kanoh H, Hunt D.
Curr Eye Res, 14:1041–1043, 1995. - Correlation of loss of heterozygosity with cytogenetic analysis using g-banding and fluorescence in situ hybridization in aneuploid cultures from two human testicular germ-cell tumors.
Al-Jehani RMA, Wells D, Fox M, Parrington JM.
Cancer Genet Cytogenet, 85:26–36, 1995. - Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli.
Gayther SA, Wells D, SenGupta SB, Chapman P, Neale K, Tsioupra K, Delhanty JDA.
Hum Mol Genet, 3:53–56, 1994. - Clinical experience with preimplantation diagnosis of sex by dual fluorescent in situ hybridization.
Griffin DK, Handyside AH, Harper JC, Wilton LJ, Atkinson G, Soussis I, Wells D, Kontogianni E, Tarin J, Geber S.
J Assist Reprod Genet, 11:132–143, 1994. - Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32.
Fitzgibbon J, Appukuttan B, Gayther S, Wells D, Delhanty J, Hunt D.
Hum Genet, 93:79-80, 1994. - Germline rearrangement of MCC and APC detected by pulsed field gel electrophoresis and fluorescent in situ hybridization.
Gayther SA, Wells D, Gulati K, Chapman P, Burn J, Delhanty JDA.
Ann Hum Genet, 57:169–178, 1993.
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Presentations
- Esbert M Garcia C Georgina Cutts Evelin Lara-Molina Seli E Ballesteros A Garrido N Mariona Quera Scott RT Wells D Fragouli ER P-17 OOCYTE IN VITRO MATURATION DOES NOT ADVERSELY AFFECT THE PROGRESSION OF THE FIRST MEIOTIC DIVISION. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020
- Stanley KE Thomas E Megan Leaver Wells D P-572 CORONAVIRUS DISEASE (COVID-19): TRANSCRIPTOMIC AND PROTEOMIC INVESTIGATION OF CELLS OF THE MALE AND FEMALE REPRODUCTIVE SYSTEMS TO EVALUATE SARS-COV-2 INFECTION RISK. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020
- Venturas M Kumar K Yang X Wells D Catherine Racowsky Dan Needleman O-81 NON-INVASIVE METABOLIC IMAGING OF CUMULUS CELLS TO DETECT OOCYTE MATURITY AND FERTILIZATION. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020
- Venturas M Kumar K Yang X Wells D Catherine Racowsky Dan Needleman P-44 METABOLIC IMAGING OF CUMULUS CELLS AND EMBRYO OUTCOME. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020
- Costa-Borges N Nikitos E Katharina Spath Klaus Rink Kostaras K Zervomanolakis I Kontopoulos G Polyzos P Grigorakis S Prokopakis T Vasilopoulos Y Vlahos N de Ziegler D Wells D O-172 FIRST REGISTERED PILOT TRIAL TO VALIDATE THE SAFETY AND EFFECTIVENESS OF MATERNAL SPINDLE TRANSFER TO OVERCOME INFERTILITY ASSOCIATED WITH POOR OOCYTE QUALITY. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020
- Fragouli Babariya Cutts G Lozoya Garcia V Fernandez Marcos E Parnell L Symon-Allen A Bronet F Florensa M Prados N Mercader A Garrido N Wells D O-295 The influence of poor semen parameters on embryonic chromosome segregation. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology, Copenhagen,Denmark, July 5-8, 2020
- Leaver M Kubikova N Tao X Jalas C Wells D O-270 A nobel long-range DNA sequencing approach improves the design of new protocols for preimplantation genetic testing of monogenic disease (PGT-M).. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology, Copenhagen,Denmark, July 5-8, 2020
- Kumar K Venturas M Needleman D Racowsky C Wells D Frequency of mitochondrial genetic variations in human cumulus cells and their association with mitochondrial function, embryo quality and BMI. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology, Copenhagen,Denmark, July 5-8, 2020
- Maria Sanchez-Reyes J Spath K Sebastian-Leon P Wells D Diaz-Gimeno P S-214 Determination of Optimal Housekeeping Genes for Transcriptional Study of the Endometrium . Presented at the 67th Annual Meeting of the Society for Reproductive Investigation, Vancouver ,Canada, March 10-14, 2020
- Esbert M Cristina García Garrido N Lara-Molina EE Wells D Seli E Georgina Cutts Ballesteros A Javier Herreros Marissa Riqueros Fragouli E O-112 Use of next generation sequencing for the analysis of in vitro matured oocytes and their polar bodies. Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology, Vienna, Austria, 14-16 October 2019
- Costa-Borges N Nikitos E Spath K Wells D Rink K Vasilopoulus Y Zervomanolakis I Konstantinos D Panagiotis P Kontopoulos G Grigorakis S Kontopoulos d Kostaras K Psathas P Calderón G O-11 Preliminary results from the first registered pilot trial with maternal spindle transfer to overcome infertility 2019
- Margarida E Rodriguez J Wells D Bassas L Loiudice I Casas A Joumady M Guerin A Ballesteros A Fragouli E P-743: Lack of consistency in the execution and reporting of sperm FISH poses potential problems for clinical interpretation and patient counselling 2019
- Tiegs W Tao X Landis J Rajchel J Bedard JL Seli E Wells D Fragouli E Scott RT Evaluation of sperm mitochondrial dna copy number as a predictor of in vitro fertilization/intracytoplasmic sperm injection (ivf/icsi) cycle outcomes in a large infertile population 2018
- Costa-Borges N Spath K Nikitos E Ribustello L Miguel-Escalada I Rink K Kostaras K Psathas P Wells D Calderon G Cytoplasm replacement by spindle transfer demonstrates enhanced embryo development without compromising euploidy rates: pre-clinical study with donor oocytes 2018
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