Dr. Elisa Varela is the Principal Investigator of the Telomeres and Telomerase in Reproduction Group at FIVI-IVIRMA, Madrid, supported partly by a Torres Quevedo Contract. She obtained her Ph. D. in Biological Sciences, at the Autonomous University of Madrid in 1998, under the direction of Dr. M.J. Martínez, where she learned biochemistry and molecular biology, working with fungal enzymes involved in wood degradation. In 1999, she joined the laboratory led by Dr. M. Tien, at Pennsylvania State University (State College, PA, USA) as a postdoctoral fellow to learn the chemistry of free radicals and reactive oxygen species that attack wood.
During these years she had frequent contact with the laboratory of Dr. J. Workman, who was working on chromatin remodelers, directing her attention to the field of chromatin regulation and dynamics. In 2004, she returned to Europe and joined the laboratory of Prof. S. M. Gasser, in Switzerland, as a postdoctoral fellow.
She analyzed the mechanisms that coordinate chromosome decompaction with exit from mitosis and the re-localization of chromatin (rDNA and telomeres) to reform the architecture of functional postmitotic nucleus. During this period, she collaborated with Prof. S. Esposito, studying the transition from the first to the second meiotic division. She also visited the laboratory of Dr. F. Uhlmann in London, with an EMBO Short Term Fellowship. She mastered yeast genetics, cell biology and high resolution confocal microscopy. In 2009, she came back to Spain as staff scientist in the group of Dr. M. A. Blasco to continue her work with telomere dynamics and regulation in cancer, aging and the biology of stem cells, in the context of mammalian organisms.
Dr. Varela has collaborated with several outstanding scientists and published several original articles, most of them as first author, in high impact journals such as EMBO, PNAS and Nature Communications. She has participated as investigator in competitive projects funded both by the Spanish Government and the European Union.
Dr. Varela has been involved in teaching, taking part as a Faculty in the Masters Program of Molecular Genetics, organized by Universidad Autónoma, Universidad Complutense and Universidad de Alcalá de Henares, since 2014 and other seminars related to telomeres and organismal fitness and health. She has been invited to give talks in international meetings and has been an active member of several Scientific Societies.
Honores y reconocimientos
|Torres Quevedo Contract. Ministery of Economy, Industry and Competitivity, Spain||2017|
|Fellowship Fundación Rafael del Pino for the Superior Course of Women and Leadership||2014-2015|
|EMBO short-term fellowship to visit the laboratory of F. Uhlmann||2008|
|Co-applicant with S. Gasser on a grant funded by the Swiss Cancer League||2004 – 2008|
|Postdoctoral Fellowship, Ministry of Education, Spain||2004 – 2006|
|US Department of Energy Fellowship, USA||1999 – 2003|
|European Union Fellowship, Spain||1992 – 1998|
Impact of Ovarian Aging in Reproduction: From Telomeres and Mice Models to Ovarian Rejuvenation.
Polonio AM Chico-Sordo L Córdova-Oriz I Medrano M García-Velasco JA Varela E
Yale J Biol Med. 2020 Sep 30;93(4):561-569. eCollection 2020 Sep.
Mathematical model to study the aging of the human follicle according to the telomerase activity.
Portillo AM Varela E García-Velasco JA
J Theor Biol, 462:446-454, 2018.
Fertility, IVF and reproductive genetics.
Varela E Sánchez-de-Puerta I García-Velasco JA
Curr Opin Obstet Gynecol, 30(3):203-208, 2018.
Should we consider telomere length and telomerase activity in male factor infertility?
Balmori C Varela E
Curr Opin Obstet Gynecol, 30(3):197-202, 2018.
A Glenohumeral joint model for rehabilitation exoskeleton SOFI. Clinical trial and results.
Varela Sanz J Saltarén RJ López J Älvarez J Varela E
IEEE Systems Journal, 14 (under review). 2017.
Telomeres in aging and reproduction.
Varela E Sánchez de Puerta I García-Velasco JA
Current Opinion in Obstetrics and Gynecology (in preparation).
Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations
Varela E Muñoz M Tejera M Ortega I Blasco M
Nature Communications, 7: 11739-11755.2016.
Different telomere-length dynamics at the Inner Cell Mass versus Established Embryonic Stem (ES) cells.
Varela E Schneider RP Ortega S Blasco MA
Proc Nat Acad USA, 108:15207-15212. 2011.
Mitotic expression of Spo13 alters M-phase progression and nucleolar localization of Cdc14 in budding yeast.
Varela E Schlecht U Moina A Fackenthal JD Washburn BK Niederhauser-Wiederkehr C Tsai-Pflugfelder M Primig M Gasser SM Esposito RE
Visualizing yeast chromosomes and nuclear architecture.
Meister P Gehlen LR Varela E Kalck V Gasser SM
Methods in Enzymology, Guide to Yeast Genetics, Molecular and Cell Biology., 470: 535-567. 201. Gutherie C, Fink G. Academic Press. 2010.
2009 Nobel prize in phisyiology or medicine: telomeres and telomerase.
Varela E Blasco MA
Oncogene, 11: 1561-1565.2010.
TGF-beta regulates expression of transcription factor KLF6 and its splice variants, and promotes co-operative transactivation of common target genes through a Smad3/Sp1/KLF6 interaction.
Botella LM Sanz-Rodriguez F Komi Y Fernandez-L A Varela E Garrido-Martin EM Narla G Friedman SL Kojima S
Biochem. J., 419: 485-495. 2009.
Lte1, Cdc14 and MEN-controlled Cdk inactivation in yeast coordinate rDNA decompaction with late telophase progression.
Varela E Shimada K Laroche T Leroy D Gasser SM
EMBO J., 28:1562-1575. 2009.
Functional localization of DNA damage to pore complex bound to Slx5/8 SUMO-dependent E3 ligase
Nagai S Dubrana K Tsai-Pflufelder M Davidson M Roberts T Brown G Varela E Hediger F Gasser SM Krogan NJ
Science, 322: 597-602. 2008.
The effect of pH and oxalate on hydroquinone-derived hydroxyl radical formation in brown-rot wood degradation
Varela E Tien M
Appl. and Env. Microbiology, 69: 6025-6031. 2003.
Culture conditions affecting biodegradation components of the brown-rot fungus: Gloeophyllum trabeum.
Varela E Mester T Tien M
Arch. Microbiology., 180: 251-256. 2003
A cross-talk between hypoxia and TGF-? orchestrates erytropoietin gene regulation through SP1 and SMADS.
Sanchez-Elsner T Ramirez JR Sanz F Varela E Bernabeu C Botella LM
J. Mol. Biol., 336: 9-24. 2003.
Expression of Pleurotus eryngii aryl-alcohol oxidase in Aspergillus nidulans: purification and characterization of the recombinant enzyme.
Varela E Guillen F Martinez AT Martinez MJ.
Biochem. Biophys. Acta, 1546: 107-13. 2001.
Biochemical characterization, cDNA cloning and protein crystallization of aryl-alcohol oxidase from Pleurotus pulmonarius. Biochim.
Varela E Bockle B Romero A Martinez AT Martinez MJ
Biophys. Acta, 1476:129-38. 2000
Aryl-alcohol oxidase protein sequence: a comparison with glucose oxidase and other FAD oxidoreductases.
Varela E Martinez AT Martinez MJ
Biochem. Biophys. Acta, 1481: 202-8. 2000.
Southern blot screening for lignin peroxidase and aryl-alcohol oxidase genes in 30 fungal species
Varela E Martinez AT Martinez MJ
Biotechnology, 83: 245-251. 2000.
Molecular cloning of aryl-alcohol oxidase from the fungus Pleurotus eryngii, an enzyme involved in lignin degradation.
Varela E Martinez AT Martinez MJ
Biochem. J., 341: 113-117. 1999.
Progress in biopulping of non-woody materials: Chemical, enzymatic and ultrastructural aspects of wheat straw dlignification with ligninolytic fungy from the genus Pleurotus.
Martinez AT Camarero S Guillén F Gutierrez A Muñoz C Varela E Martinez MJ Barrasa JM Ruel K Pelayo JM
FEMS Microbiol. Rev., 13: 265-274. 1994.
- Chico-Sordo L Soler I Mateu-Pascual JM Córdova-Oriz I Polonio AM Marta Medrano María J Soriano Garcia-Velasco JA Varela E P-358 EFFECT OF DISTAL CANCER ON THE TELOMERIC LENGTH OF OVARIAN CORTEX CELLS. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020
- Córdova-Oriz I García-Panadero R Guillermo De Alba Pacheco A Carlos Balmori Chico-Sordo L Polonio AM Marta Medrano Garcia-Velasco JA Thomas M D’Hooghe Varela E Psathas P P-956 OLDER OLIGOASTHENOZOOSPERMIC MEN HAVE ALTERED TELOMERE BIOLOGY AND LESS CHANCES THAN CONTROLS FOR ASSISTED REPRODUCTIVE TECHNOLOGY OUTCOMES (ART).. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020
- Sánchez-de-Puerta I González-García M Varela E Mor A Implications of Telomere Biology in Female Reproductive Aging Using the SAMP8 Mouse Model. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona, Spain, March 12-16, 2019