María José Escribá, Ph.D.

Head investigator at IVI Valencia and FIVI-INCLIVA

IVI Valencia

María José Escribá, Ph.D.

Biography

Dr. María José Escribá is a head investigator at IVI Valencia and FIVI-INCLIVA, a Senior embryologist at IVI RMA Valencia, and a post-graduate teaching faculty at University of Valencia and ADEIT.She obtained her Bachelor’s degree in Biology at the University of Valencia in 1994 and then, continued her pre-doctoral training by developing reproductive biotechnologies in several livestock species. Her doctoral thesis entitled: “Hemicloning technology in the rabbit” recevied the Extraordinary Doctoral Thesis Prize from the Polytechnique University of Valencia, in 2000.

In 2001, she started working at IVI Valencia, sponsored by the IDE Action and since then, Dr Escribá was encouraged to one unique end: to develop biotechnologies in the field of human reproduction. The first Dr. Escribá’s contribution was to develop and translate to the clinical practice the first European vitrification protocol for human blastocysts, in 2003. Additionally, a second line, still in force, was based on rescuing non-viable tripronucleated and unipronucleated human eggs, resulting from an anomalous fertilization after IVF or ICSI by self-correction or microsurgical correction. Since 2003, Dr. Escribá combines her research activity with the clinical IVF practice, which allows her to make her efforts relevant to the needs of those who require assisted reproduction. Dr. Escribà’s main topic areas of interest are in vitro rescue of immature GV oocytes, recovered from stimulated cycles; fertility preservation in cancer patients by ovarian cortex cryopreservation; pre-conceptional genetic diagnosis of human gametes and gamete genome editing by Crispr-Cas9 technology.

Dr. Escribá participates as principal investigator in more than 10 competitive research projects, funded through regional (Generalitat Valenciana) and national (FIS Projects and CDTi) mechanisms. In addition, she serves as scientific advisor for the National Agency for Assessment and Prospective (ANECA) and regular reviewer for numerous reproductive journals. Dr. Escriba contributed to five doctoral thesis, published more than 45 original manuscripts and book chapters, and had approximately 50 presentations in national and international meetings.

Dr. Escribá aims to transmit her knowledge to undergraduate, graduate, and post-doctoral trainees, and to share her passion for research and innovation, not only as a career but also as a lifestyle. Her involvement in education began in her early career, teaching graduate courses of Biotechnology of Reproduction at the Veterinary Faculty of Valencia and four postgraduate courses. Dr. Escribá was accredited by the National Agency for Assessment and Accreditation (ANECA) in 2016 for university education and since 2003, she is Coordinator of the Modules: Fertilization and Embryo Development; Cryobiology and Gamete and Embryo Multiplication for the Master’s Degree in Biotechnology of Assisted Human Reproduction.


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Education and Training

B.S. Biology, University of Valencia, Spain (1994)
Ph.D. (Biology) Polytechnique University of Valencia, Spain (2000)
Fellowship Pre-doctoral: Regional Government Support
Post-doctoral: Incorporation of PhD to enterprises, Ministry of Industry Embryologist Certificate Embryologist Certificate
Senior Embryologist ESHRE, 2008
Senior Embryologist ASEBIR, 2009
Associated Professor ANECA, 2016)
University Teaching Accreditation
Titular Professor for Private University ANECA, 2016
Extraordinary Doctoral Thesis Prize
Dr. Cobo University of Valencia 2003
Dr. Grau University of Valencia 2016

Honors and recognition

ASEBIR Award, ASEBIR 2009
Special PhD award 2000

Publications


  • The reproductive outcome of germinal vesicle oocytes recovered from stimulated cycles.
    Escrich L, Galiana Y, Grau N, Insúa F, Pellicer A, Remohi J, Escribá MJ.
    RBMOnline (in preparation)

  • Kinetics of the early development of uniparental human haploid embryos.
    Escribá MJ, Escrich L, Galiana Y, Grau N, Galán A, Pellicer A.
    Fertil Steril, 105(5):1360-1368, 2016.

  • Morphokinetic analysis and embryonic prediction for blastocyst formation through an integrated time-lapse system.
    Motato Y, de los Santos MJ, Escribá MJ, Ruiz BA, Remohí J, Meseguer M.
    Fertil Steril, 105(2):376-84, 2016.

  • Morphokinetics as a predictor of self-correction to diploidy in tripronucleated intracytoplasmic sperm injection-derived human embryos.
    Grau N, Escrich L, Galiana Y, Meseguer M, García-Herrero S, Remohí J, Escribá MJ.
    Fertil Steril, 104(3):728-35, 2015.

  • The human first cell cycle: impact on implantation.
    Aguilar J, Motato Y, Escribá MJ, Ojeda M, Muñoz E, Meseguer M.
    Reprod Biomed Online, 28(4):475-84, 2014.

  • Short-term storage of tripronucleated human embryos.
    Grau N, Aparicio B, Escrich L, Mercader A, Delgado A, Remohí J, Escribá MJ.
    J Assist Reprod Genet, 30(8):1043-7, 2013.

  • Spontaneous in vitro maturation of oocytes prior to ovarian tissue cryopreservation in natural cycles of oncologic patients.
    Escribá MJ, Grau N, Escrich L, Novella-Maestre E, Sánchez-Serrano M.
    J Assist Reprod Genet, 29(11):1261-5, 2012.

  • Limited implantation success of direct-cleaved human zygotes: a time-lapse study.
    Rubio I, Kuhlmann R, Agerholm I, Kirk J, Herrero J, Escribá MJ, Bellver J, Meseguer M. Fertil Steril, 98(6):1458-63, 2012.

  • The dynamics of in vitro maturation of germinal vesicle oocytes.
    Escrich L, Grau N, de los Santos MJ, Romero JL, Pellicer A, Escribá MJ.
    Fertil Steril, 98(5):1147-51, 2012.

  • Self-correction in tripronucleated human embryos.
    Grau N, Escrich L, Martín J, Rubio C, Pellicer A, Escribá MJ.
    Fertil Steril, 96(4):951-6, 2011.


  • Spontaneous in vitro maturation and artificial activation of human germinal vesicle oocytes recovered from stimulated cycles.
    Escrich L, Grau N, Mercader A, Rubio C, Pellicer A, Escribá MJ.
    J Assist Reprod Genet, 28(2):111-7, 2011.

  • Twins born after transplantation of ovarian cortical tissue and oocyte vitrification.
    Sánchez-Serrano M, Crespo J, Mirabet V, Cobo AC, Escribá MJ, Simón C, Pellicer A
    Fertil Steril, 93(1):268.e11-3, 2010.

  • Vitrification of isolated human blastomeres.
    Escribá MJ, Grau N, Escrich L, Pellicer A.
    Fertil Steril, 93(2):669-71, 2010.

  • Morphologic indicators predict the stage of chromatin condensation of human germinal vesicle oocytes recovered from stimulated cycles.
    Escrich L, Grau N, Meseguer M, Pellicer A, Escribá MJ
    Fertil Steril, 93(8):2557-64, 2010.

  • Vitrification of preimplantation genetically diagnosed human blastocysts and its contribution to the cumulative ongoing pregnancy rate per cycle by using a closed device.
    Escribá MJ, Zulategui JF, Galán A, Mercader A, Remohí J, de los Santos MJ.
    Fertil Steril, 89(4):840-6, 2008.

  • Heteroparental blastocyst production from microsurgically corrected tripronucleated human embryos.
    Escribá MJ, Martín J, Rubio C, Valbuena D, Remohí J, Pellicer A, Simón C.
    Fertil Steril, 86(6):1601-7, 2006.

  • J.Ultrastructure of preimplantation genetic diagnosis-derived human blastocysts grown in a coculture system after vitrification.
    Escribá MJ, Escobedo-Lucea C, Mercader A, de los Santos MJ, Pellicer A, Remohí
    Fertil Steril, 86(3):664-71, 2006.

  • Delaying the initiation of progesterone supplementation until the day of fertilization does not compromise cycle outcome in patients receiving donated oocytes: a randomized study.
    Escribá MJ, Bellver J, Bosch E, Sánchez M, Pellicer A, Remohí J.
    Fertil Steril, 86(1):92-7, 2006.

  • Vitrification of in vitro cultured rabbit morulae.
    Silvestre MA, Saeed AM, Escribá MJ, García-Ximénez F.
    Anim Reprod Sci, 76(1-2):113-24, 2003.

  • Rabbit and pig ear skin sample cryobanking: effects of storage time and temperature of the whole ear extirpated immediately after death.
    Silvestre MA, Saeed AM, Cervera RP, Escribá MJ, García-Ximénez F.
    Theriogenology, 59(5-6):1469-77, 2003.

  • Vitrification and rapid freezing of rabbit fetal tissues and skin samples from rabbits and pigs.
    Silvestre MA, Saeed AM, Escribá MJ, García-Ximénez F.
    Theriogenology, 58 (1):69-76, 2002.

  • New techniques on embryo manipulation.
    Escribá MJ, Valbuena D, Remohí J, Pellicer A, Simón C.
    J Reprod Immunol, 55(1-2):149-61. Review, 2002.

  • Viable offspring derived from cryopreserved haploid rabbit parthenotes.
    García-Ximénez F, Escribá MJ.
    Theriogenology, 57(4):1319-25, 2002.

  • Comparison of the effect of two different handling media on rabbit zygote developmental ability.
    Escribá MJ, Silvestre MA, Saeed AM, García-Ximénez F.
    Reprod Nutr Dev, 41(2):181-6, 2001.

  • Reconstruction of the heteroparental diploid condition in rabbit zygotes by nuclear transfer.
    Escribá MJ, García-Ximénez F.
    Theriogenology, 55(3):771-84, 2001.

  • Vitrification and rapid-freezing of cumulus cells from rabbits and pigs.
    Saeed AM, Escribá MJ, Silvestre MA, Garcia-Ximénez F.
    Theriogenology, 54(9):1359-71, 2000.

  • Use of a variable electrical pulsing sequence in rabbit oocyte activation.
    Escribá MJ, García-Ximénez F.
    Reprod Nutr Dev, 40(3):261-9, 2000.

  • Influence of sequence duration and number of electrical pulses upon rabbit oocyte activation and parthenogenetic in vitro development.
    Escribá MJ, García-Ximénez F.
    Anim Reprod Sci, 59(1-2):99-107, 2000.

  • Electroactivation of rabbit oocytes in an hypotonic pulsing medium and parthenogenetic in vitro development without cytochalasin B-diploidizing pretreatment.
    Escribá MJ, García-Ximénez F.
    Theriogenology, 51(5):963-73, 1999.


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