Francisco Dominguez, Ph.D.

Biografía

Dr. Dominguez is a full-time lead investigator at FIVI-IIS LaFe, the laboratory manager for the IVI Foundation Research Department, and the Head of the Reproductive Biology and Bioengineering in Human Reproduction at IIS La Fe Hospital.He completed his Bachelor’s degree in Biology at the University of Valencia in 1998 and obtained his doctorate degree “cum laude” in 2003 in the Pediatrics, Obstetrics, and Gynaecology Department of the University of Valencia School of Medicine. He pursued his post-doctoral training at the CNIC (Spanish National Center for Cardiovascular Research) and at the Hospital de la Princesa in Madrid, as well as at the Principe Felipe Research Center in Valencia.

As a researcher, his main focus is on studying the endometrium and the human embryo implantation process at both the transcriptomic and proteomic levels, while also developing new non-invasive aneuploidy diagnostic systems. Dr. Dominguez has published over 70 original peer-reviewed articles in leading reproductive journals (e.g., Human Reproduction, Fertility & Sterility, Human Reproduction Update, JCEM) and has written more than 15 book chapters on human embryo implantation and endometrial receptivity.

He has participated as a researcher in competitive projects both as an emerging researcher (Generalitat Valenciana) and as a lead researcher (FIS Projects, Miguel Servet contracts). He has also served as a regular editor for numerous specialized journals in the field of reproductive medicine and was a former Associate Editor at Human Reproduction, the leading and most influential journal in the field of Reproductive Medicine.

Dr. Dominguez has been involved in teaching since the early stages of his career, imparting postgraduate courses since 2003. He is currently the Coordinator of the Basic Research in Human Reproduction Module for the Master’s Degree in Biotechnology of Assisted Human Reproduction (formerly the doctoral program of the Pediatrics, Obstetrics, and Gynaecology Department of the University of Valencia School of Medicine), offered by ADEIT since 2001.

From 2009 until June 2011, Dr. Dominguez also served as Scientific Director at Embryomics, an organization dedicated to developing non-invasive aneuploidy diagnostic systems. He has received several awards for his research projects, including the ICIRA Award in 2009, the Spanish Fertility Society Award in 2000, and the Salud 2000 Foundation Award in 2004.

Formación

B.Sc.	University of Valencia, Spain (1998)
Ph.D (Biology)	University of Valencia, Spain (2003)
Fellowship	CNIC/La Princesa Hospital, Madrid, Spain (2005)

Honores y reconocimientos

Fertility and Sterility Star Reviewer , at the 75th annual meeting of the American Society of Reproductive Medicine (ASRM)	2019
Merck-Serono Award, Salud 2000 Foundation. Clinical investigation Area	2015
Associate Editor Human Reproduction	2013
ICIRA Award, to the best IVF innovation Project	2009
Merck Serono Award, Salud 200 Foundation. Clinical investigation Area	2004
Spanish Fertility Society Award	2000

Publicaciones

Longitudinal profiling of human androgenotes through single-cell analysis unveils paternal gene expression dynamics in early embryo development.
Vendrell X, de Castro P, Escrich L, Grau N, Gonzalez-Martin R, Quiñonero A, Escribá MJ, Domínguez F

Hum Reprod. 2024 Apr 15:deae072. doi: 10.1093/humrep/deae072. Online ahead of print.. 2024 doi:

Higher Concentrations of Essential Trace Elements in Women Undergoing IVF May Be Associated with Poor Reproductive Outcomes Following Single Euploid Embryo Transfer.
Gonzalez-Martin R, Palomar A, Perez-Deben S, Salsano S, Quiñonero A, Caracena L, Fernandez-Saavedra R, Fernandez-Martinez R, Conde-Vilda E, Quejido AJ, Giles J, Vidal C, Bellver J, Dominguez F

Cells. 2024 May 15;13(10):839. doi: 10.3390/cells13100839.. 2024 doi:

Proteomic Profiling Identifies Candidate Diagnostic Biomarkers of Hydrosalpinx in Endometrial Fluid: A Pilot Study.
Gonzalez-Martin R, de Castro P, Fernandez C, Quintana F, Quiñonero A, Ferrando M, Dominguez F

Int J Mol Sci. 2024 Jan 12;25(2):968. doi: 10.3390/ijms25020968.. 2024 doi:

The effect of vitrification on blastocyst mitochondrial DNA dynamics and gene expression profiles.
Pérez-Sánchez M, Pardiñas ML, Díez-Juan A, Quiñonero A, Domínguez F, Martin A, Vidal C, Beltrán D, Mifsud A, Mercader A, Pellicer A, Cobo A, de Los Santos MJ

J Assist Reprod Genet. 2023 Oct 6. doi: 10.1007/s10815-023-02952-3. Online ahead of print.. 2023 doi:

Editorial: Single cell analysis in endocrinology, reproduction, and metabolism.
Dominguez F, Blesson CS

Front Endocrinol (Lausanne). 2023 Oct 23;14:1282987. doi: 10.3389/fendo.2023.1282987. eCollection 2023.. 2023 doi:

Antioxidant Supplementation Alleviates Mercury-Induced Cytotoxicity and Restores the Implantation-Related Functions of Primary Human Endometrial Cells.
Palomar A, Quiñonero A, Medina-Laver Y, Gonzalez-Martin R, Pérez-Debén S, Alama P, Domínguez F

Int J Mol Sci. 2023 May 15;24(10):8799. doi: 10.3390/ijms24108799.. 2023 doi:

Association of blood cadmium and lead levels with self-reported reproductive lifespan and pregnancy loss: The national health and nutrition examination survey 1999-2018.
Gonzalez-Martin R, Grau-Perez M, Sebastian-Leon P, Diaz-Gimeno P, Vidal C, Tellez-Plaza M, Dominguez F

Environ Res. 2023 Jun 29;233:116514. doi: 10.1016/j.envres.2023.116514. Online ahead of print.. 2023 doi:

Bioaccumulation of Non-Essential Trace Elements Detected in Women's Follicular Fluid, Urine, and Plasma Is Associated with Poor Reproductive Outcomes following Single Euploid Embryo Transfer: A Pilot Study.
Palomar A, Gonzalez-Martin R, Quiñonero A, Pellicer N, Fernandez-Saavedra R, Rucandio I, Fernandez-Martinez R, Conde-Vilda E, Quejido AJ, Zuckerman C, Whitehead C, Scott RT, Dominguez F

Int J Mol Sci. 2023 Aug 24;24(17):13147. doi: 10.3390/ijms241713147.. 2023 doi:

Deciphering a shared transcriptomic regulation and the relative contribution of each regulator type through endometrial gene expression signatures.
Parraga-Leo A, Sebastian-Leon P, Devesa-Peiro A, Marti-Garcia D, Pellicer N, Remohi J, Dominguez F, Diaz-Gimeno P

Reprod Biol Endocrinol. 2023 Sep 12;21(1):84. doi: 10.1186/s12958-023-01131-4.. 2023 doi:

Mosaic results after preimplantation genetic testing for aneuploidy may be accompanied by changes in global gene expression.
Martin A, Mercader A, Dominguez F, Quiñonero A, Perez M, Gonzalez-Martin R, Delgado A, Mifsud A, Pellicer A, De Los Santos MJ

Front Mol Biosci. 2023 Apr 14;10:1180689. doi: 10.3389/fmolb.2023.1180689. eCollection 2023.. 2023 doi:

Phytoestrogens Present in Follicular Fluid and Urine Are Positively Associated with IVF Outcomes following Single Euploid Embryo Transfer.
Gonzalez-Martin R, Palomar A, Quiñonero A, Pellicer N, Zuckerman C, Whitehead C, Scott RT Jr, Dominguez F

Int J Mol Sci. 2023 Jun 29;24(13):10852. doi: 10.3390/ijms241310852.. 2023 doi:

The Impact of Essential Trace Elements on Ovarian Response and Reproductive Outcomes following Single Euploid Embryo Transfer.
Gonzalez-Martin R, Palomar A, Quiñonero A, Pellicer N, Fernandez-Saavedra R, Conde-Vilda E, Quejido AJ, Whitehead C, Scott RT Jr, Dominguez F

Int J Mol Sci. 2023 Jun 30;24(13):10968. doi: 10.3390/ijms241310968. 2023 doi:

The NR2F2-HAND2 signaling axis regulates progesterone actions in the uterus at early pregnancy.
Oh Y, Quiroz E, Wang T, Medina-Laver Y, Redecke SM, Dominguez F, Lydon JP, DeMayo FJ, Wu SP

Front Endocrinol (Lausanne). 2023 Aug 18;14:1229033. doi: 10.3389/fendo.2023.1229033. eCollection 2023.. 2023 doi:

Comparative single-cell transcriptomic profiles of human androgenotes and parthenogenotes during early development.
de Castro P, Vendrell X, Escrich L, Grau N, Gonzalez-Martin R, Quiñonero A, Dominguez F, Escribá MJ

Fertil Steril. 2022 Dec 20:S0015-0282(22)02118-5. doi: 10.1016/j.fertnstert.2022.12.027. Online ahead of print.. 2022 doi:

Endometrial Cells Acutely Exposed to Phthalates In Vitro Do Not Phenocopy Endometriosis.
Gonzalez-Martin R, Palomar A, Medina-Laver Y, Quiñonero A, Domínguez F

Int J Mol Sci. 2022 Sep 20;23(19):11041. doi: 10.3390/ijms231911041.. 2022 doi:

Mercury impairs human primary endometrial stromal cell function.
Palomar A, González-Martín R, Pérez-Debén S, Medina-Laver Y, Quiñonero A, Domínguez F

Biol Reprod. 2022 doi: 10.1093/biolre/ioac016

What Do We Know about Classical and Non-Classical Progesterone Receptors in the Human Female Reproductive Tract? A Review.
Medina-Laver Y, Rodríguez-Varela C, Salsano S, Labarta E, Domínguez F

Int J Mol Sci. 2021 doi:

Presentaciones

Palomar A Sanvicente M Sánchez-Mejías A Jaraba-Wallace J Quiñonero A Dominguez F Güell M Sánchez-Ribas I Targeted Elimination of Human Chromosome 21 (HSA21) in Adult and Embryo Stem Cell Lines Using a Novel CRISPR-Cas3 Genome-Editing Tool. , , March 21-25,2023

Palomar A Gonzalez-Martin R Salsano S Pérez-Debén S Quiñonero A Domínguez F O-105 Entosis Occurs in Human Embryo Implantation.. Presented at the 67th Annual Meeting of the Society for Reproductive Investigation, Vancouver ,Canada, March 10-14,2020

Gonzalez-Martin R Palomar A Pérez-Debén S Quiñonero A Dominguez F F-209 Mercury Disturbs Reproductive Functions of Primary Endometrial Stromal Cells (ESC).. Presented at the 67th Annual Meeting of the Society for Reproductive Investigation, Vancouver ,Canada, March 10-14,2020

Pellicer N Buigues A Dominguez F Susana Martinez-cuenca Pellicer A Herraiz S P-787 Autologous stem cell ovarian transplantation (ASCOT) revitalized the aged blood-borne secretome in Poor responder (PR) women. Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology, Vienna,Austria, 14-16 October 2019

Marin L Campos-Galindo I Dominguez F De los Santos MJ Mercader A Simon C Rubio C P-574 Effect of genistein and daidzein levels on ovarian response and embryo quality in PGT-A cycles. Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology, Paris,France, 14-16 October 2019

Meseguer M Bori L Del Gallego R Remohí J Quinonero A Dominguez F P-134: Protein profile of euploid single embryo transfer reveals differential patterns among them.. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver,CO,USA, 23-26 June 2019

Ferrero H Corachán A Quiñonero A Bougeret C Pellicer A Dominguez F . P-315: Inhibition of KIF20A reduces endometriosis implants in a randomized xenograft mouse model. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver,CO,USA, 23-26 June 2019

Ferrero H Corachán A Quiñonero A Carbajo-García C Alamá P Tejera A Taboas E Muñoz E Pellicer A Domínguez F NGS of Oocytes from Endometriosis Patients Reveals a Differential Transcriptomic Pattern. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona,Spain, March 12-16,2019

Gonzalez-Martin R Quiñonero A Pérez S Salsano S Domínguez F Acute DEHP Exposure in Endometrial Epithelial Cells Does Not Phenocopy the Alterations Described in Endometriosis.. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona,Spain, March 12-16,2019

Gonzalez-Martin R Telez-Plaza M Domínguez F Association of Blood Cadmium and Lead Levels with Reproductive Lifespan Among Postmenopausal Women: NHANES 2005-2014. . Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona,Spain, March 12-16,2019