Francisco Dominguez, Ph.D.

Laboratory Manager & Endometrial Receptivity and Embryonic Competence Research Group Leader at the IVI Foundation Research Department

FIVI Valencia

Francisco Dominguez, Ph.D.

Biografía

Dr. Dominguez is a full-time head investigator at FIVI-INCLIVA through a type I Miguel Servet contract and laboratory manager for the IVI Foundation Research department. He completed his Bachelor’s degree in Biology at the University of Valencia in 1998, and obtained his doctorate degree “cum laude” in 2003 in the Pediatrics, Obstetrics and Gynaecology Department of the University of Valencia School of Medicine. He did his post-doctoral training at the CNIC (Spanish National Center for Cardiovascular Research) and at the Hospital de la Princesa in Madrid, as well as at the Principe Felipe Research Center in Valencia.

As a researcher, his main focus is the study of the endometrium and the human embryo implantation process, both at transcriptomic and at proteomic levels, without dismissing the embryonic aspect, developing new non-invasive aneuploidy diagnostic systems.

As a researcher, Dr Domínguez has published over 45 original “peer review” articles in leading reproductive journals (Hum Reprod, Fertil & Steril, PLos One, JCEM, etc.) and wrote than 15 book chapters on the human embryo implantation and endometrial receptivity.

He has also participated as researcher in competitive projects both as emerging researcher (Generalitat Valenciana), and as lead researcher (FIS Projects, Miguel Servet contracts), besides acting as regular editor in numerous specialized journals in the field of reproductive medicine. He is presently Associated Editor at Human Reproduction, the first Reproductive Medicine journal and the most influential in its field.

Dr. Domínguez has been involved in teaching since his early career, imparting postgraduate courses since 2003. Presently he is the Coordinator of the Basic Research in Human Reproduction Module from the Master’s Degree in Biotechnology of Assisted Human Reproduction (former doctorate degree of the Pediatrics, Obstetrics and Gynaecology Department of University of Valencia School of Medicine) given by ADEIT since 2001.

Dr. Domínguez has also worked as Scientific Director at Embryomics, an organization dedicated to the development of non-invasive aneuploidy diagnostic systems, from 2009 until June 2011 and he has received several awards for his research projects, including the ICIRA Award in 2009, the Spanish Fertility Society Award (2000) and the Salud 2000 Foundation Award (2004).

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Formación

B.Sc. University of Valencia (1998), Spain
Ph.D (Biology) University of Valencia (2003), Spain
Fellowship CNIC/La Princesa Hospital, Madrid, Spain (2005)

Honores y reconocimientos

Merck-Serono Award, Salud 2000 Foundation. Clinical investigation Area 2015
Merck Serono Award, Salud 200 Foundation. Clinical investigation Area 2004
ICIRA Award, to the best IVF innovation Project 2009
Spanish Fertility Society Award 2000
Associate Editor Human Reproduction 2013

Publicaciones


  • The metabolomic profile of spent culture media from day-3 human embryos cultured under low oxygen tension.
    De Los Santos MJ, Gamiz P, de Los Santos JM, Romero JL, Prados N, Alonso C, Remohi J, Dominguez F.
    Plos One. 10:(e0142724), pp. 1 - 15, 2015.

  • Deciphering the proteomic signature of human endometrial receptivity.
    Garrido-Gómez T, Quiñonero A, Antúnez O, Diaz-Gimeno P, Bellver J, Simón C, Dominguez F.
    Hum Reprod, 29:1957-67, 2014.

  • Embryonic miRNA profiles of normal and ectopic pregnancies.
    Dominguez F, Moreno-Moya JM, Lozoya T, Romero A, Martínez S, Monterde M, Gurrea M, Ferri B, Núñez MJ, Simón C, Pellicer A.
    Plos One, 11:e102185, 2014.


  • Detection of Missing Proteins Using the PRIDE Database as a Source of Mass Spectrometry Evidence.
    Segura V, Corrales FJ, Vizcaino JA, Sanchez del Pino MM, Dominguez F Garrido N, Rivera R, Cantero L, Molina M, Martínez R, Del Toro N, Martinez-Val A, Odriozola L, Garin-Muga A.
    J Prot Res, 15:4101-5, 2016.

  • Day 3 embryo metabolomics in the spent culture media is altered in obese women undergoing in vitro fertilization.
    Bellver J, Jose Delos Santos M, Alama P, Castelló D, Privitera L, Galiano D, Labarta E, Vidal C, Pellicer A, Dominguez F.
    Fertil Steril, 103:1407-15, 2015.

  • Follicular fluid and mural granulosa cells microRNA profiles vary in in vitro fertilization patients depending on their age and oocyte maturation stage.
    Moreno JM, Núñez MJ, Quiñonero A, Martínez S, DelaOrden M, Simón C, Pellicer A, Diaz-Garcia C, Dominguez F.
    Fertil Steril, 104:1037-46, 2015.

  • New strategy for diagnosing embryo implantation potential by combining proteomics and time-lapse technologies.
    Dominguez F, Meseguer M, Aparicio-Ruiz B, Piqueras P, Quiñonero A, Simon C.
    Fertil Steril, 104:908-14, 2015.

  • Soluble Ligands and their receptors in human embryo development and implantation.
    Thouas G, Dominguez F, Vilella F, Simón C, Gardner D.
    Endocrine Rev, 36:92-130, 2015.

  • The Lin28/Let-7 system in early human embryonic tissue and ectopic pregnancy.
    Lozoya T, Dominguez F, Romero-Ruiz A, Steffani L, Martínez S, Monterde M, Ferri B, Núñez MJ, Romero-Espinos A, Zamora O, Gurrea M, Vega O, Sangiao-Alvarellos S, Simon C, Pellicer A, Tena-Sempere M.
    Plos One, 9:e87698. 2014.

  • Effect of vitrification on human oocytes: a metabolic profiling study.
    Dominguez F, Castello D, Remohí J, Simon C, Cobo A.
    Fertil Steril, 99:565-72, 2013.

  • Annexin A2 is critical for embryo adhesiveness to the human endometrium by RhoA activation through F-actin regulation.
    Garrido-Gomez T, Dominguez F, Quiñonero A, Estella C, Vilella F, Pellicer A, Simon C.
    Faseb J, 26:3715-27, 2012.

  • Differential metabolic profiling of non-pure trisomy 21 human preimplantation embryos.
    Sánchez-Ribas I, Riqueros M, Vime P, Puchades-Carrasco L, Jönsson T, Pineda-Lucena A, Ballesteros A, Domínguez F, Simón C.
    Fertil Steril, 98:1157, 2012.

  • Proteomics of the endometrium and associated pathologies.
    Dominguez F, Santamaria J, Sánchez-Ribas I, Pellicer A.
    Medicine de la Reproduction Gynecologie Endocrinologie. 14:295 – 306, 2012.

  • The analysis of endometrial receptivity. Textbook of Assisted Reproductive Techniques 4th Edition. pp. 366-379.
    Garrido-Gomez T, Dominguez F, Ruiz M, Vilella F, Simon C.
    Informa Healthcare, 2012.

  • Contemporary genetic technologies and female reproduction.
    Evian Annual Reproduction (EVAR) Workshop Group 2010, Fauser BC, Diedrich K, Bouchard P, Domínguez F, Matzuk M, Franks S, Hamamah S, Simón C, Devroey P, Ezcurra D, Howles CM.
    Hum Reprod Update, 17:829-47, 2011.

  • Modeling human endometrial decidualization from the interaction between proteome and secretome.
    Garrido-Gómez T, Domínguez F, López JA, Camafeita E, Quiñonero A, Martínez-Conejero JÁ, Pellicer A, Conesa A, Simón C.
    J Clin Endocrinol Metabol 96:706-16, 2011.

  • Embryologic outcome and secretome profile of implanted blastocysts obatined alter coculture in human endometrial epithelial cells versus the sequential system.
    Dominguez F, Gadea B, Mercader A, Esteban FJ, Pellicer A, Simón C.
    Fertil Steril, 93:774-82, 2010.

  • Human endometrial CD98 is essential for blastocyst adhesion.
    Dominguez F, Simon C, Quiñonero A, Ramirez MA, Gonzalez-Muñoz E, Burghardt H, Cervero A, Martinez S, Pellicer A, Palacin A, Sanchez-Madrid F, Yañez-Mo M.
    Plos One, 15 - 5, 2010.

  • Proteomics of embryonic implantation. Handbook of Experimental Pharmacology. 198, pp. 67 - 78.
    Garrido-Gomez T, Dominguez F, Simon C.
    Springer USA, 2010.

  • Novel non-invasive diagnosis of endometriosis. Endometriosis. Current management and future trends. pp. 100 – 107.
    Dominguez F.
    Jaypee Brothers Medical Publisher, 2010.

  • Proteomic analysis of the human receptive versus non-receptive endometrium using differential in-gel electrophoresis and MALDI-MS unveils stathmin 1 and annexin A2 as differentially regulated.
    Domínguez F, Garrido-Gómez T, López JA, Camafeita E, Quiñonero A, Pellicer A, Simón C.
    Hum Reprod 24:2607–17, 2009.

  • The human embryo proteome.
    Dominguez F, Pellicer A, Simon C.
    Reprod Sci, 16:188- 190. 2009.

  • Embryonic and maternal dialogue and the analysis of uterine receptivity. Textbook of Assisted Reproductive Technologies. pp. 427-434.
    Dominguez F, Horcajadas JA, Simon C.
    Informa healthcare, 2009.

  • Embryonic and maternal dialogue and the analysis of uterine receptivity. Textbook of Assisted Reproductive Technologies, Laboratory and Clinical Perspectives. Third Edition pp. 427 – 43
    Domínguez F, Horcajadas JA, Simón C.
    4, Informa healthcare, 2009.

  • CXCL10 and IL-6 induce chemotaxis in human trophoblast cell lines.
    Domínguez F, Martinez S, Quiñonero A, Loro F, Horcajadas JA, Pellicer A, Simón C.
    Molecular Hum Reprod 14:423-30, 2008.

  • Comparative protein-profile analysis of implanted versus non-implanted human blastocysts.
    Dominguez F, Gadea B, Esteban FJ, Horcajadas JA, Pellicer A, Simon C.
    Hum Reproduc 23:1993-2000, 2008.

  • Controlled ovarian stimulation induces a functional genomic delay of the endometrium with potential clinical implications.
    Horcajadas JA, Minguez P, Dopazo J, Esteban FJ, Dominguez F, Giudice LC, Pellicer A, Simon C.
    J Clin Endocrinol Metab, 93:4500-10, 2008.

  • Embryo-endometrial signaling. The endometrium.2 nd edition Molecular, Cellular and Clinical Perspectives. pp. 296 - 304.
    Domínguez F, Simón C.
    Informa healthcare, 2008.

  • Molecular mechanisms of implantation. Infertility and Assisted Reproduction, pp. 46 - 52.
    Domínguez F, Simón C, García-Velasco JA.
    Cambridge University Press, 2008.

  • Embryonic adhesion is not affected by endometrial leptin receptor gene silencing.
    Cervero A, Domínguez F, Horcajadas JA, Quiñonero A, Pellicer A, Simón C.
    Fertil Steril, 88 (Suppl 2):1086-92, 2007.

  • Effect of an intrauterine device on the gene expression profile of the endometrium.
    Horcajadas JA, Sharkey AM, Catalano RD, Sherwin JR, Dominguez F, Burgos LA, Castro A, Peraza MR, Pellicer A, Simon C.
    J Clin Endocrinol Metab, 91:3199-207, 2006.

  • Embryo-endometrial interaction.
    Valles CS, Dominguez F.
    Chang Gung Med J, 29:9-14, 2006.

  • The role of the leptin in reproduction.
    Cervero A, Dominguez F, Horcajadas JA, Quinonero A, Pellicer A, Simon C.
    Curr Opin Obstet Gynecol, 18:297-303, 2006.

  • Determinants of Endometrial Receptivity.
    Horcajadas JA, Riesewijk A, Domínguez F, Cervero A, Pellicer A, Simón A.
    Annals of the New York Academy of Sciences. 1034:166-75, 2005.

  • Embryonic Implantation and Leukocyte Transendothelial Migration. Different processes with similar players.
    Domínguez F, Yañez-Mó M, Sanchez-Madrid F, Simón C.
    Faseb J, 19:1056-60, 2005.

  • Leptin System in embryo development andimplantation: a protein in search of a function.
    Cervero A, Horcajadas JA, Domínguez F, Pellicer A, Simon C.
    Reprod Biomed Online, 10:217-23, 2005.

  • Molecular basis on implantation.
    Pellicer A, Domínguez F, Horcajadas JA, Simon C.
    J Physiol Biochem, 61:29, 2005.

  • Embryo interactions in human implantation. Implantation and Early Development. 1, pp. 79 - 89.
    Domínguez F; Horcajadas JA; Cervero A; Pellicer A; Simón C.
    ROCG Press, 2005.

  • Embryo interactions in human implantation. Implantation and early development. pp. 79 – 89.
    F. Domínguez; J.A. Horcajadas; A. Cervero; A. Pellicer; C. Simón.
    Royal College of Obstetricians and Ginaecologist Press, 2005.

  • Embryonic-endometrial interactions at implantation in humans.
    Simon C, Dominguez F.
    Gynecol Obstet Invest, 57:28-30, 2004.

  • Embryonic Regulation in the process of implantation. Textbook of Assisted Reproductive Technology, 2nd edition. pp. 413 - 423.
    Domínguez F, Pellicer A, Simon C.
    Taylor and Francis, Inc. 2004.

  • Implantation and uterine receptivity. Internacional Congress Series 1266,pp. 177 – 182.
    Horcajadas J, Domínguez F, Martín J, Pellicer A, Simón C.
    Elsevier, 2004.

  • Gene expresión pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle.
    Luna Martin JJ, Riesewijk A, Horcajadas J, van Os R, Domínguez F, Mosselman S, Pellicer A, Simon C.
    Mol Hum Reprod, 10:85-90, 2004.

  • A combined approach for gene discovery identifies IGFBP.rP1 as a New Gene Implicated in human endometrial receptivity.
    Dominguez F, Avila S, Martin J, Cervero A, Castrillo JL, Simón C.
    J Clin Endocrino Metab, 88: 1849-57, 2003.

  • Hormonal and embryonic regulation of chemokine receptors CXCR1, CXCR4, CCR5 and CCR2B in the human endometrium and the human blastocyst.
    Dominguez F, Galan A, Martin JJ, Remohi J, Pellicer A, Simon C.
    Mol Hum Reprod, 9:189-98, 2003.

  • Human endometrial receptivity: a genomic approach.
    Domínguez F, Remohi J, Pellicer A, Simon C.
    Reprod Biomed Online, 6:330-6, 2003.

  • The Chemokine connection: hormonal and embryonic regulation at the maternal-embryonic Interface. A review.
    Domínguez F, Pellicer A, Simon C.
    Placenta, 24, 2003.

  • The role of estrogen in uterine receptivity and blastocyst implantation.
    Simon C, Domínguez F. Valbuena D, Pellicer A.
    Trends in Endocrinol Metab, 14: 197-9, 2003.

  • Hormonal and embyonic regulation of chemokines IL-8, MCP-1 and RANTES in the human endometrial epithelium.
    Caballero-Campo P, Dominguez F, Coloma J, Meseguer M, Remohí J, Pellicer A, Simón C.
    Mol Hum Reprod, 8:375-84, 2002.

  • Human endometrial receptivity: gene regulation.
    Martin J, Dominguez F, Avila S, Castrillo JL, Remohi J, Pellicer A, Simon C.
    J Reprod Immunol, 55:131-9, 2002.

  • Molecular Basis of Implantation.
    Pellicer A, Dominguez F, Remohí J, Simon C.
    Reprod Biomed Online, 5: 44 – 51, 2002.

  • Paracrine dialogue in implantation.
    Dominguez F, Pellicer A, Simón C.
    Mol Cell Endocrinol, 186: 175-81, 2002.

  • Paracrine interactions during human implantation.
    Dominguez F, Remohi J, Pellicer A, Simon C.
    Rev Endoc Metab Dis, 3:97-105, 2002.

  • Embryonic regulation of endometrial receptivity in humans. In Advances in Infertility Treatment.
    Simon C, Dominguez F, Pellicer A.
    Monduzzi Editore, pp. 381 - 396. SpA, 2002.

  • Embryo effects in human implantation: embryonic regulation of endometrial molecules in human implantation.
    Simón C, Dominguez F, Pellicer A.
    Annals New York Acad Sci, 943:1–16, 2001.

  • Embryo-endometrial interactions. infertility and reproductive medicine.
    Domínguez F, Martín J, Navarro J, Pellicer A, Simón C.
    Clin North Am Obstet Gynecol, 12:373-87, 2000.

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Vídeos

Study about human endometrium
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