Francisco Dominguez, Ph.D.

Biografía

Dr. Dominguez is a full-time head investigator at FIVI-INCLIVA through a type I Miguel Servet contract and laboratory manager for the IVI Foundation Research department. He completed his Bachelor’s degree in Biology at the University of Valencia in 1998, and obtained his doctorate degree “cum laude” in 2003 in the Pediatrics, Obstetrics and Gynaecology Department of the University of Valencia School of Medicine. He did his post-doctoral training at the CNIC (Spanish National Center for Cardiovascular Research) and at the Hospital de la Princesa in Madrid, as well as at the Principe Felipe Research Center in Valencia.

As a researcher, his main focus is the study of the endometrium and the human embryo implantation process, both at transcriptomic and at proteomic levels, without dismissing the embryonic aspect, developing new non-invasive aneuploidy diagnostic systems.

As a researcher, Dr Domínguez has published over 45 original “peer review” articles in leading reproductive journals (Hum Reprod, Fertil & Steril, PLos One, JCEM, etc.) and wrote than 15 book chapters on the human embryo implantation and endometrial receptivity.

He has also participated as researcher in competitive projects both as emerging researcher (Generalitat Valenciana), and as lead researcher (FIS Projects, Miguel Servet contracts), besides acting as regular editor in numerous specialized journals in the field of reproductive medicine. He is presently Associated Editor at Human Reproduction, the first Reproductive Medicine journal and the most influential in its field.

Dr. Domínguez has been involved in teaching since his early career, imparting postgraduate courses since 2003. Presently he is the Coordinator of the Basic Research in Human Reproduction Module from the Master’s Degree in Biotechnology of Assisted Human Reproduction (former doctorate degree of the Pediatrics, Obstetrics and Gynaecology Department of University of Valencia School of Medicine) given by ADEIT since 2001.

Dr. Domínguez has also worked as Scientific Director at Embryomics, an organization dedicated to the development of non-invasive aneuploidy diagnostic systems, from 2009 until June 2011 and he has received several awards for his research projects, including the ICIRA Award in 2009, the Spanish Fertility Society Award (2000) and the Salud 2000 Foundation Award (2004).

Formación

B.Sc.	University of Valencia (1998), Spain
Ph.D (Biology)	University of Valencia (2003), Spain
Fellowship	CNIC/La Princesa Hospital, Madrid, Spain (2005)

Honores y reconocimientos

Merck-Serono Award, Salud 2000 Foundation. Clinical investigation Area	2015
Merck Serono Award, Salud 200 Foundation. Clinical investigation Area	2004
ICIRA Award, to the best IVF innovation Project	2009
Spanish Fertility Society Award	2000
Associate Editor Human Reproduction	2013

Publicaciones

Diet and environmental factors affecting reproduction
Dominguez F, Ruiz MJ

Med Reprod y Embr Clínica. Jun. 2021 doi: 10.1016/j.medre.2021.100102

Deciphering the role of PGRMC1 during human decidualization using an in vitro approach.
Salsano S, González-Martín R, Quiñonero A, Perez-Deben S, Dominguez F

J Clin Endocrinol Metab. May. 2021 doi: 10.1210/clinem/dgab303

Differential sperm proteomic profiles according to pregnancy achievement in intracytoplasmic sperm injection cycles: a pilot study.
Rivera-Egea R, Sota N, Gonzalez-Martín R, Meseguer M, Remohi J, Garrido N, Dominguez F

J Assist Reprod Genet. Apr. 2021 doi: 10.1007/s10815-021-02098-0

Uterine natural killer cells: from foe to friend in reproduction.
Díaz-Hernández I, Alecsandru D, Garcia-Velasco J A, Dominguez F

Hum Reprod Update. Feb. 2021 doi: 10.1093/humupd/dmaa062

Differential sperm proteomic profiles according to pregnancy achievement in intracytoplasmic sperm injection cycles: a pilot study
Rivera-Egea R, Sota N, Gonzalez-Martin R, Meseguer M, Remohi J, Garrido N, Dominguez F,

J Assist Reprod Genet. Apr. 2021 doi: 10.1007/s10815-021-02098-0

Uterine natural killer cells: from foe to friend in reproduction
Diaz-Hernandez I, Alecsandru D, Garcia-Velasco J A, Dominguez F,

Hum Reprod Update. 2-Feb. 2021 doi: 10.1093/humupd/dmaa062

Cytokines in embryonic secretome as potential markers for embryo selection
Bahrami-Asl Z, Hajipour H, Rastgar Rezaei Y, Novinbahador T, Latifi Z, Nejabati H R, Farzadi L, Fattahi A, Nouri M, Dominguez F,

Am J Reprod Immunol. May. 2021 doi: 10.1111/aji.13385

An artificial intelligence model based on the proteomic profile of euploid embryos and blastocyst morphology: a preliminary study
Bori L, Dominguez F, Fernandez E I, Del Gallego R, Alegre L, Hickman C, Quinonero A, Nogueira M F G, Rocha J C, Meseguer M,

Reprod Biomed Online. Feb. 2021 doi: 10.1016/j.rbmo.2020.09.031

Comparison of different sources of platelet-rich plasma as treatment option for infertility-causing endometrial pathologies
de Miguel-Gomez L, Lopez-Martinez S, Campo H, Frances-Herrero E, Faus A, Diaz A, Pellicer A, Dominguez F, Cervello I,

Fertil Steril. Feb. 2021 doi: 10.1016/j.fertnstert.2020.07.053

Tacrolimus Improves the Implantation Rate in Patients with Elevated Th1/2 Helper Cell Ratio and Repeated Implantation Failure (RIF)
Bahrami-Asl Z, Farzadi L, Fattahi A, Yousefi M, Quinonero A, Hakimi P, Latifi Z, Nejabati H R, Ghasemnejad T, Sadigh A R, Heidari M H, Nouri M, Novin M G, Dominguez F,

Geburtshilfe Frauenheilkd. Aug. 2020 doi: 10.1055/a-1056-3148

Novel nonclassic progesterone receptor PGRMC1 pulldown-precipitated proteins reveal a key role during human decidualization
Salsano S, Gonzalez-Martin R, Quinonero A, Lopez-Martin S, Gomez-Escribano A P, Perez-Deben S, Yanez-Mo M, Dominguez F,

Fertil Steril. 2020 May. doi: 10.1016/j.fertnstert.2020.01.008

Identifying biomarkers for predicting successful embryo implantation: applying single to multi-OMICs to improve reproductive outcomes
Hernandez-Vargas P, Muñoz M, Dominguez F,

Hum Reprod Update. 2020 Feb. doi: 10.1093/humupd/dmz042

Copper and lead exposures disturb reproductive features of primary endometrial stromal and epithelial cells
Perez-Deben S, Gonzalez-Martin R, Palomar A, Quinonero A, Salsano S, Dominguez F,

Reprod Toxicol. 2020 Apr. doi: 10.1016/j.reprotox.2020.01.008

Preeclampsia: a defect in decidualization is associated with deficiency of Annexin A2
Garrido-Gomez T, Quinonero A, Dominguez F, Rubert L, Perales A, Hajjar K A, Simon C,

Am J Obstet Gynecol. 2020 Apr. doi: 10.1016/j.ajog.2019.11.1250

Phytoestrogen exposure alters endometrial stromal cells and interferes with decidualization signaling
Salsano S, Perez-Deben S, Quinonero A, Gonzalez-Martin R, Dominguez F,

Fertil Steril. 2019 Nov. doi: 10.1016/j.fertnstert.2019.06.014

Inhibition of KIF20A by BKS0349 reduces endometriotic lesions in a xenograft mouse model
Ferrero H, Corachan A, Quinonero A, Bougeret C, Pouletty P, Pellicer A, Dominguez F,

Mol Hum Reprod. 2019 1-Sep. doi: 10.1093/molehr/gaz044

Single-cell RNA sequencing of oocytes from ovarian endometriosis patients reveals a differential transcriptomic profile associated with lower quality
Ferrero H, Corachan A, Aguilar A, Quinonero A, Carbajo-Garcia M C, Alama P, Tejera A, Taboas E, Munoz E, Pellicer A, Dominguez F,

Hum Reprod. 2019 8-Jul. doi: 10.1093/humrep/dez053

iTRAQ comparison of proteomic profiles of endometrial receptivity
Perez-Deben S, Bellver J, Alama P, Salsano S, Quinonero A, Sebastian-Leon P, Diaz-Gimeno P, Dominguez F,

J Proteomics. 2019 15-Jul. doi: 10.1016/j.jprot.2019.103381

Phthalates and other endocrine-disrupting chemicals: the 21st century's plague for reproductive health
Dominguez F,

Fertil Steril. 2019 May. doi: 10.1016/j.fertnstert.2019.01.029

Transcriptomic behavior of genes associated with chromosome 21 aneuploidies in early embryo development
Sanchez-Ribas I, Diaz-Gimeno P, Sebastian-Leon P, Mercader A, Quinonero A, Ballesteros A, Pellicer A, Dominguez F,

Fertil Steril. 2019 May. doi: 10.1016/j.fertnstert.2019.01.023

Deregulation of miR-324/KISS1/kisspeptin in early ectopic pregnancy: mechanistic findings with clinical and diagnostic implications
Romero-Ruiz A, Avendano M S, Dominguez F, Lozoya T, Molina-Abril H, Sangiao-Alvarellos S, Gurrea M, Lara-Chica M, Fernandez-Sanchez M, Torres-Jimenez E, Perdices-Lopez C, Abbara A, Steffani L, Calzado M A, Dhillo W S, Pellicer A, Tena-Sempere M,

Am J Obstet Gynecol. 2019 May. doi: 10.1016/j.ajog.2019.01.228

NGS Analysis of Human Embryo Culture Media Reveals miRNAs of Extra Embryonic Origin
Sanchez-Ribas I, Diaz-Gimeno P, Quinonero A, Ojeda M, Larreategui Z, Ballesteros A, Dominguez F,

Reprod Sci. 2019 Feb. doi: 10.1177/1933719118766252

Sperm lipidic profiles differ significantly between ejaculates resulting in pregnancy or not following intracytoplasmic sperm injection
Rivera-Egea R, Garrido N, Sota N, Meseguer M, Remohi J, Dominguez F,

J Assist Reprod Genet. 2018 Nov. doi: 10.1007/s10815-018-1284-4

Search for new molecular biomarkers to diagnose endometriosis continues
Dominguez F,

Fertil Steril. 2018 Apr. doi: 10.1016/j.fertnstert.2017.12.018

Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology
Garrido-Gomez T, Dominguez F, Quinonero A, Diaz-Gimeno P, Kapidzic M, Gormley M, Ona K, Padilla-Iserte P, McMaster M, Genbacev O, Perales A, Fisher S J, Simon C,

Proc Natl Acad Sci U S A. 2017 3-Oct. doi: 10.1073/pnas.1706546114

Dynamic expression of PGRMC1 and SERBP1 in human endometrium: an implication in the human decidualization process
Salsano S, Quinonero A, Perez S, Garrido Gomez T, Simon C, Dominguez F,

Fertil Steril. 2017 Nov. doi: 10.1016/j.fertnstert.2017.07.1163

Lipidomic profiling of endometrial fluid in women with ovarian endometriosisdagger
Dominguez F, Ferrando M, Diaz-Gimeno P, Quintana F, Fernandez G, Castells I, Simon C,

Biol Reprod. 2017 Apr 1. doi: 10.1093/biolre/iox014

Detection of Missing Proteins Using the PRIDE Database as a Source of Mass Spectrometry Evidence
Garin-Muga A, Odriozola L, Martinez-Val A, Del Toro N, Martinez R, Molina M, Cantero L, Rivera R, Garrido N, Dominguez F, Sanchez Del Pino M M, Vizcaino J A, Corrales F J, Segura V,

J Proteome Res. 2016 4-Nov. doi: 10.1021/acs.jproteome.6b00437

The Metabolomic Profile of Spent Culture Media from Day-3 Human Embryos Cultured under Low Oxygen Tension
de Los Santos M J, Gamiz P, de Los Santos J M, Romero J L, Prados N, Alonso C, Remohi J, Dominguez F,

PLoS One. 2015 doi: 10.1371/journal.pone.0142724

Follicular fluid and mural granulosa cells microRNA profiles vary in in vitro fertilization patients depending on their age and oocyte maturation stage
Moreno J M, Nunez M J, Quinonero A, Martinez S, de la Orden M, Simon C, Pellicer A, Diaz-Garcia C, Dominguez F,

Fertil Steril. 2015 Oct. doi: 10.1016/j.fertnstert.2015.07.001

New strategy for diagnosing embryo implantation potential by combining proteomics and time-lapse technologies
Dominguez F, Meseguer M, Aparicio-Ruiz B, Piqueras P, Quinonero A, Simon C,

Fertil Steril. 2015 Oct. doi: 10.1016/j.fertnstert.2015.06.032

Day-3 embryo metabolomics in the spent culture media is altered in obese women undergoing in vitro fertilization
Bellver J, De Los Santos M J, Alama P, Castello D, Privitera L, Galliano D, Labarta E, Vidal C, Pellicer A, Dominguez F,

Fertil Steril. 2015 Jun. doi: 10.1016/j.fertnstert.2015.03.015

Soluble ligands and their receptors in human embryo development and implantation
Thouas G A, Dominguez F, Green M P, Vilella F, Simon C, Gardner D K,

Endocr Rev. 2015 Feb. doi: 10.1210/er.2014-1046

Deciphering the proteomic signature of human endometrial receptivity
Garrido-Gomez T, Quinonero A, Antunez O, Diaz-Gimeno P, Bellver J, Simon C, Dominguez F,

Hum Reprod. 2014 Sep. doi: 10.1093/humrep/deu171

Embryonic miRNA profiles of normal and ectopic pregnancies
Dominguez F, Moreno-Moya J M, Lozoya T, Romero A, Martinez S, Monterde M, Gurrea M, Ferri B, Nunez M J, Simon C, Pellicer A,

PLoS One. 2014 doi: 10.1371/journal.pone.0102185

Effect of vitrification on human oocytes: a metabolic profiling study
Dominguez F, Castello D, Remohi J, Simon C, Cobo A,

Fertil Steril. 2013 Feb. doi: 10.1016/j.fertnstert.2012.09.034

Differential metabolic profiling of non-pure trisomy 21 human preimplantation embryos
Sanchez-Ribas I, Riqueros M, Vime P, Puchades-Carrasco L, Jonsson T, Pineda-Lucena A, Ballesteros A, Dominguez F, Simon C,

Fertil Steril. 2012 Nov. doi: 10.1016/j.fertnstert.2012.07.1145

Annexin A2 is critical for embryo adhesiveness to the human endometrium by RhoA activation through F-actin regulation
Garrido-Gomez T, Dominguez F, Quinonero A, Estella C, Vilella F, Pellicer A, Simon C,

FASEB J. 2012 Sep. doi: 10.1096/fj.12-204008

Contemporary genetic technologies and female reproduction
Evian Annual Reproduction Workshop Group, Fauser B C, Diedrich K, Bouchard P, Dominguez F, Matzuk M, Franks S, Hamamah S, Simon C, Devroey P, Ezcurra D, Howles C M,

Hum Reprod Update. 2011 Nov-Dec. doi: 10.1093/humupd/dmr033

Modeling human endometrial decidualization from the interaction between proteome and secretome
Garrido-Gomez T, Dominguez F, Lopez J A, Camafeita E, Quinonero A, Martinez-Conejero J A, Pellicer A, Conesa A, Simon C,

J Clin Endocrinol Metab. 2011 Mar. doi: 10.1210/jc.2010-1825

Controlled ovarian stimulation induces a functional genomic delay of the endometrium with potential clinical implications
Horcajadas J A, Minguez P, Dopazo J, Esteban F J, Dominguez F, Giudice L C, Pellicer A, Simon C,

J Clin Endocrinol Metab. 2008 Nov. doi: 10.1210/jc.2008-0588

Comparative protein-profile analysis of implanted versus non-implanted human blastocysts
Dominguez F, Gadea B, Esteban F J, Horcajadas J A, Pellicer A, Simon C,

Hum Reprod. 2008 Sep. doi: 10.1093/humrep/den205

CXCL10 and IL-6 induce chemotaxis in human trophoblast cell lines
Dominguez F, Martinez S, Quinonero A, Loro F, Horcajadas J A, Pellicer A, Simon C,

Mol Hum Reprod. 2008 Jul. doi: 10.1093/molehr/gan032

Embryonic adhesion is not affected by endometrial leptin receptor gene silencing
Cervero A, Dominguez F, Horcajadas J A, Quinonero A, Pellicer A, Simon C,

Fertil Steril. 2007 Oct. doi: 10.1016/j.fertnstert.2006.12.028

Effect of an intrauterine device on the gene expression profile of the endometrium
Horcajadas J A, Sharkey A M, Catalano R D, Sherwin J R, Dominguez F, Burgos L A, Castro A, Peraza M R, Pellicer A, Simon C,

J Clin Endocrinol Metab. 2006 Aug. doi: 10.1210/jc.2006-0430

The role of the leptin in reproduction
Cervero A, Dominguez F, Horcajadas J A, Quinonero A, Pellicer A, Simon C,

Curr Opin Obstet Gynecol. 2006 Jun. doi: 10.1097/01.gco.0000193004.35287.89

Embryo-endometrial interaction
Valles C S, Dominguez F,

Chang Gung Med J. 2006 Jan-Feb. doi:

Embryonic implantation and leukocyte transendothelial migration: different processes with similar players?
Dominguez F, Yanez-Mo M, Sanchez-Madrid F, Simon C,

FASEB J. 2005 Jul. doi: 10.1096/fj.05-3781hyp

Leptin system in embryo development and implantation: a protein in search of a function
Cervero A, Horcajadas J A, Dominguez F, Pellicer A, Simon C,

Reprod Biomed Online. 2005 Feb. doi: 10.1016/s1472-6483(10)60943-1

Determinants of endometrial receptivity
Horcajadas J A, Riesewijk A, Dominguez F, Cervero A, Pellicer A, Simon C,

Ann N Y Acad Sci. 2004 Dec. doi: 10.1196/annals.1335.019

Gene expression pattern and immunoreactive protein localization of LGR7 receptor in human endometrium throughout the menstrual cycle
Luna J J, Riesewijk A, Horcajadas J A, Van Os Rd Rd, Dominguez F, Mosselman S, Pellicer A, Simon C,

Mol Hum Reprod. 2004 Feb. doi: 10.1093/molehr/gah019

The chemokine connection: hormonal and embryonic regulation at the human maternal-embryonic interface--a review
Dominguez F, Pellicer A, Simon C,

Placenta. 2003 Oct. doi: 10.1016/s0143-4004(03)00134-6

The role of estrogen in uterine receptivity and blastocyst implantation
Simon C, Dominguez F, Valbuena D, Pellicer A,

Trends Endocrinol Metab. 2003 Jul. doi: 10.1016/s1043-2760(03)00084-5

Human endometrial receptivity: a genomic approach
Dominguez F, Remohi J, Pellicer A, Simon C,

Reprod Biomed Online. 2003 Apr-May. doi: 10.1016/s1472-6483(10)61853-6

A combined approach for gene discovery identifies insulin-like growth factor-binding protein-related protein 1 as a new gene implicated in human endometrial receptivity
Dominguez F, Avila S, Cervero A, Martin J, Pellicer A, Castrillo J L, Simon C,

J Clin Endocrinol Metab. 2003 Apr. doi: 10.1210/jc.2002-020724

Hormonal and embryonic regulation of chemokine receptors CXCR1, CXCR4, CCR5 and CCR2B in the human endometrium and the human blastocyst
Dominguez F, Galan A, Martin J J, Remohi J, Pellicer A, Simon C,

Mol Hum Reprod. 2003 Apr. doi: 10.1093/molehr/gag024

Molecular basis of implantation
Pellicer A, Dominguez F, Remohi J, Simon C,

Reprod Biomed Online. 2002 doi: 10.1016/s1472-6483(11)60216-2

Human endometrial receptivity: gene regulation
Martin J, Dominguez F, Avila S, Castrillo J L, Remohi J, Pellicer A, Simon C,

J Reprod Immunol. 2002 May-Jun. doi: 10.1016/s0165-0378(01)00140-1

Paracrine interactions during human implantation
Dominguez F, Remohi J, Pellicer A, Simon C,

Rev Endocr Metab Disord. 2002 May. doi: 10.1023/a:1015498610742

Hormonal and embryonic regulation of chemokines IL-8, MCP-1 and RANTES in the human endometrium during the window of implantation
Caballero-Campo P, Dominguez F, Coloma J, Meseguer M, Remohi J, Pellicer A, Simon C,

Mol Hum Reprod. 2002 Apr. doi: 10.1093/molehr/8.4.375

Paracrine dialogue in implantation
Dominguez F, Pellicer A, Simon C,

Mol Cell Endocrinol. 2002 Jan 25. doi: 10.1016/s0303-7207(01)00659-1

Embryo effects in human implantation: embryonic regulation of endometrial molecules in human implantation
Simon C, Dominguez F, Remohi J, Pellicer A,

Ann N Y Acad Sci. 2001 Sep. doi: 10.1111/j.1749-6632.2001.tb03785.x

Presentaciones

Palomar A Gonzalez-Martin R Salsano S Pérez-Debén S Quiñonero A Domínguez F O-105 Entosis Occurs in Human Embryo Implantation.. Presented at the 67th Annual Meeting of the Society for Reproductive Investigation, Vancouver ,Canada, March 10-14, 2020

Gonzalez-Martin R Palomar A Pérez-Debén S Quiñonero A Dominguez F F-209 Mercury Disturbs Reproductive Functions of Primary Endometrial Stromal Cells (ESC).. Presented at the 67th Annual Meeting of the Society for Reproductive Investigation, Vancouver ,Canada, March 10-14, 2020

Pellicer N Buigues A Dominguez F Susana Martinez-cuenca Pellicer A Herraiz S P-787 Autologous stem cell ovarian transplantation (ASCOT) revitalized the aged blood-borne secretome in Poor responder (PR) women. Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology, Vienna, Austria, 14-16 October 2019

Marin L Campos-Galindo I Dominguez F De los Santos MJ Mercader A Simon C Rubio C P-574 Effect of genistein and daidzein levels on ovarian response and embryo quality in PGT-A cycles. Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology, Paris, France, 14-16 October 2019

Meseguer M Bori L Del Gallego R Remohí J Quinonero A Dominguez F P-134: Protein profile of euploid single embryo transfer reveals differential patterns among them.. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver, CO, USA, 23-26 June 2019

Ferrero H Corachán A Quiñonero A Bougeret C Pellicer A Dominguez F . P-315: Inhibition of KIF20A reduces endometriosis implants in a randomized xenograft mouse model. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver, CO, USA, 23-26 June 2019

Ferrero H Corachán A Quiñonero A Carbajo-García C Alamá P Tejera A Taboas E Muñoz E Pellicer A Domínguez F NGS of Oocytes from Endometriosis Patients Reveals a Differential Transcriptomic Pattern. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona, Spain, March 12-16, 2019

Gonzalez-Martin R Quiñonero A Pérez S Salsano S Domínguez F Acute DEHP Exposure in Endometrial Epithelial Cells Does Not Phenocopy the Alterations Described in Endometriosis.. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona, Spain, March 12-16, 2019

Gonzalez-Martin R Telez-Plaza M Domínguez F Association of Blood Cadmium and Lead Levels with Reproductive Lifespan Among Postmenopausal Women: NHANES 2005-2014. . Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona, Spain, March 12-16, 2019

Gonzalez-Martin R Quiñonero A Pérez-Debent S Salsano S Domínguez F Endometrial Stromal Cells Acutely Exposed to DEHP Do Not Recapitulate Alterations Observed in Endometriosis_. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona, Spain, March 12-16, 2019