
María José De los Santos, Ph.D
Director of the Clinical Embryology Laboratory at IVI Valencia
IVI Valencia
María José De los Santos, Ph.D
Biografía
Dr. Maria J. de los Santos started her career in 1991 in the IVF laboratory of IVI Valencia. She received her Ph.D. in Biology from University of Valencia in 1996, and from 1996-1999 she carried out her postdoctoral fellowship in Reproductive Immunology at Fearing Research Laboratory at Harvard Medical School, under the supervision of Dr. Deborah Anderson and Dr. Joseph Hill. She also worked as clinical embryologist at the Brigham and Women´s Hospital under the direction of Dr. Catherine Racowsky.
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Formación
B.Sc. | Biology. University of Valencia, Spain (1990) |
Master Degree | Biology of Reproduction. University of Valencia, Spain (1991) |
Ph.D (Biology) | Valencia School of Medicine. University of Valencia, Spain (1996) |
Fellowship | Postdoctoral fellowship on Immunology of Reproduction at Fearing Research Laboratory. Harvard Medical School, MA, USA (1996-1999) |
Honores y reconocimientos
Designated participant from Spanish Government for the 3rd and 4th edition of “Guide to the Quality and Safety of Tissues and Cells for Human Application” of the European Council | 2015-present |
Past -Coordinator of Special Interest Group in Embryology ESHRE | 2015-present |
Coordinator of Special Interest Group in Embryology ESHRE | 2013-2015 |
Deputy Member of Special Interest Group in Embryology ESHRE | 2010-2013 |
Deputy of the Interest Group in Embryo Quality of ASEBIR | 2013-2015 |
Associate Editor of Medres | 2013 |
President of the Interest Group in Embryo Quality of ASEBIR | 2009-2013 |
ASEBIR Best Clinical Oral Communication Award, Valencia, Spain | 2009 |
Sociedad Española de Infertilidad Oral Communication Award, Sevilla, Spain | 2000 |
Real Colegio Complutense (RCC), Harvard Grant | 1998 |
William F. Milton Foundaiton Grant Award | 1997 |
Sociedad Española de Infertilidad Oral Communication Award, Tenerife, Spain | 1995 |
American Scoiety for Reproductive Medicine (ASRM) Award, Seattle, USA | 1994 |
Sociedad Española de Infertilidad Award, Alicante, Spain | 1991 |
Publicaciones
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The influence of oxygen concentration during embryo culture on obstetric and neonatal outcomes: a secondary analysis of a randomized controlled trial.
Rendón Abad M Serra V Gámiz P de Los Santos JM Remohí J Navarro AT de Los Santos MJ
Hum Reprod. 2020 Aug 9:deaa152. doi: 10.1093/humrep/deaa152. Online ahead of print. -
The first choice of the preimplantation embryo: How compaction and polarity build cell identity
Martín A de los Santos MJ
Medicina Reproductiva y Embriología ClínicaIn press, corrected proofAvailable online 4 March 2020 -
Registro Nacional de Actividad-Registro de la Sociedad Española de Fertilidad de fecundación in vitro e inyección espermática intracitoplasmática. Años 2016 y 2017
Irene Cuevas Prados P Isabel Pons Montserrat de Andrés Lourdes Sánchez-Castro Lafuente R de Los Santos MJ Herrero J Cabello Y Muñoz P Castel AB Canales M Castilla JA
Medicina Reproductiva y Embriología ClínicaIn press, corrected proofAvailable online 11 March 2020 -
The influence of oxygen concentration during embryo culture on obstetric and neonatal outcomes: a secondary analysis of a randomized controlled trial.
Rendón Abad M Serra V Gámiz P de Los Santos JM Remohí J Navarro AT de Los Santos MJ
Hum Reprod. 2020 Aug 9:deaa152. doi: 10.1093/humrep/deaa152. Online ahead of print. -
The first choice of the preimplantation embryo: How compaction and polarity build cell identity.
Martín A de los Santos MJ
Medicina Reproductiva y Embriología ClínicaIn press, corrected proofAvailable online 4 March 2020 -
Registro Nacional de Actividad-Registro de la Sociedad Española de Fertilidad de fecundación in vitro e inyección espermática intracitoplasmática. Años 2016 y 2017.
Cuevas I Prados F Pons I Montserrat de Andrés Sánchez-Castro L Lafuente R de los Santos MJ Herrero J Cabello Y Muñoz P Castel AB Canales M Castilla JA
Medicina Reproductiva y Embriología ClínicaIn press, corrected proofAvailable online 11 March 2020 -
Understanding the role of killer cell immunoglobulin-like receptors in pregnancy complications.
Díaz-Peña R de Los Santos MJ Lucia A Castro-Santos P
J Assist Reprod Genet. 2019 Mar 7. doi: 10.1007/s10815-019-01426-9. [Epub ahead of print] Review. -
Mitochondria as a tool for oocyte rejuvenation.
Labarta E de Los Santos MJ Escribá MJ Pellicer A Herraiz S
Fertil Steril. 2019 Jan 2. pii: S0015-0282(18)32162-9. doi: 10.1016/j.fertnstert.2018.10.036. [Epub ahead of print] Review. -
Autologous mitochondrial transfer as a complementary technique to intracytoplasmic sperm injection to improve embryo quality in patients undergoing in vitro fertilization-a randomized pilot study.
Labarta E De Los Santos MJ Herraiz S Escribà MJ Marzal A Buigues A Pellicer A
Fertil Steril, NA:NA -NA, 2018. -
Variables associated with mitochondrial copy number in human blastocysts: what can we learn from trophectoderm biopsies?
De Los Santos MJ Diez Juan A Mifsud A Mercader A Meseguer M Rubio C Pellicer A
Fertil Steril, 109(1):110-117, 2018.
- Revised guidelines for good practice in IVF laboratories.
De Los Santos MJ, Apter S, Coticchio G, Debrock S, Lundin K, Plancha CE, Prados F, Rienzi L, Verheyen G, Woodward B et al.
Hum Reprod, 31:685-686, 2016. - Morphokinetic analysis and embryonic prediction for blastocyst formation through an integrated time-lapse system.
Motato Y, De Los Santos MJ, Escriba MJ, Ruiz BA, Remohi J and Meseguer M.
Fertil Steril, 105:376-384 e379, 2016. - Day-3 embryo metabolomics in the spent culture media is altered in obese women undergoing in vitro fertilization.
Bellver J, De Los Santos MJ, Alama P, Castello D, Privitera L, Galliano D, Labarta E, Vidal C, Pellicer A and Dominguez F.
Fertility and sterility, 103:1407-1415 e1401, 2015. - The educational and professional status of clinical embryology and clinical embryologists in Europe.
Kovacic B, Plas C, Woodward BJ, Verheyen G, Prados FJ, Hreinsson J, De Los Santos MJ, Magli MC, Lundin K and Plancha CE.
Hum Reprod, 30:1755-1762, 2015. - Congenital malformations, chromosomal abnormalities and perinatal results in IVF/ICSI newborns resulting from very poor quality embryos: a case-control study.
Mendoza R, Perez S, De Los Santos MJ ,Larreategui Z, Ayerdi F, Exposito A, Burgos J, Martinez Indart L, Pijoan JI and Matorras R.
Gynecol Obstet Invest, 79:83-89, 2015. - The Metabolomic Profile of Spent Culture Media from Day-3 Human Embryos Cultured under Low Oxygen Tension.
De Los Santos MJ, Gamiz P, de Los Santos JM, Romero JL, Prados N, Alonso C, Remohi J and Dominguez F.
PloS one, 10:e0142724, 2015. - Reply of the authors.
De Los Santos MJ.
Fertil steril, 101:e35, 2014. - Protocols for tracking and witnessing samples and patients in assisted reproductive technology.
De Los Santos MJ and Ruiz A.
Fertil steril, 100:1499-1502, 2013.
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Presentations
- Pérez M Mercader A Mifsud A Diana Beltrán Vidal C Labarta E Pellicer A De los Santos MJ O-18 IS mtDNA CONTENT ASSESSMENT AN INDICATOR OF THE AMOUNT OF MITOCHONDRIA (TOTAL AND ACTIVE ONES) IN THE HUMAN BLASTOCYST?: A CONFOCAL MICROSCOPY APPROACH.. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020
- Vidal C Giles J Mollá Robles G De los Santos MJ Remohí J Cobo A P-542 LESSONS LEARNED FROM A 10 YEARS CRYOEMBRYO VITRIFICATION PROGRAM: THE AGE OF THE OOCYTE MATTERS.. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020
- De Frutos Sánchez S Ariza Lopez M Bronet F Martinez EV Gaytan M Mª Del Carmen Nogales De los Santos MJ P-1009 IS BLASTOCYST DEVELOPMENTAL RATE A GOOD PREDICTOR OF ONGOING PREGNANCY RATE IN EUPLOID BLATOCYSTS?. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020
- Tejera A Alegre L Delgado A De los Santos MJ Meseguer M P-175 Artificial oocyte activation (AOA) TREATMENT offers A NEW option in Previous unsuccessful cases due to poor fertilization history; a paired cohort sTudy. Presented at 75th American Society of Reproductive Medicine Scientific Congress, Philadelphia, PA. USA, 14-16 October 2019
- Marta Pérez Mercader A Beltrán D Delgado A Escrich L Pellicer A Vidal C De los Santos MJ P-60 Is low mitochondrial DNA (mtDNA) content after fertilization failure due to oocyte aging in culture. Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology, Vienna, Austria, 14-16 October 2019
- Ángel Martin Vidal C Rodrigo L Mercader A Rubio C Giles J Remohí J De los Santos MJ P-310 Impact of different degrees of genetic mosaicism in the kinetic profile of the human embryo. Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology, Vienna, Austria, 14-16 October 2019
- Coello A De los Santos MJ Nohales Corcoles M Meseguer M Remohí J Cobo A P-107 Impact of fresh blastocyst parameters on survival and implantation in vitrified blastocyst cycles: analysis of 11936 warmed blastocysts.. Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology, Vienna, Austria, 14-16 October 2019
- Marin L Campos-Galindo I Dominguez F De los Santos MJ Mercader A Simon C Rubio C P-574 Effect of genistein and daidzein levels on ovarian response and embryo quality in PGT-A cycles. Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology, Paris, France, 14-16 October 2019
- Insua M Díez Juan A Mercader A Bellver J Escrich L Pellicer A De los Santos MJ P-265: Total mitochondrial DNA (mtDNA) content decreases along embryo development, insights of mtDNA turnover in human preimplantation development.. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver, CO, USA, 23-26 June 2019
- Escrich L Soler N González Picazo A Buendía P Escribá MJ De los Santos MJ P-276: Effect of different commercial media on spontaneous in vitro maturation and kinetics of germinal-vesicle human oocytes. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver, CO, USA, 23-26 June 2019
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