Hortensia Ferrero, Ph.D.

Biografía

Dr. Hortensia Ferrero is a full-time investigador at IIS La Fe-FIVI through a Miguel Servet contract of the Natitonal Institute of Health Carlos III (ISCIII) 2021-2026 and research group leader for treatment and diagnosis of uterine diseases at IVI Foundation in Valencia. She obtained her Bachelors degree form the University of Valencia in 2006, with a major in Biology. She then obtained a Master’s Degree in Biotechnology and Biomedicine (2008), focusing on Human Reproductive Biology. She carried out her PhD studies with a PFIS fellowship granted by Health Institute Carlos III. In 2013, she worked six months with Dr. D. Stephen Charnock-Jones’ group at University of Cambridge in the Department of Obstetrics and Gynaecology, in the UK, supported by a grant by Health Institute Carlos III. She received her PhD degree in Biotechnology with special international mention, in 2014 from University of Valencia. Her thesis project on the angiogenic process regulating the corpus luteum in physiological and pathological conditions recieved an Extraordinary Award in 2015.

Subsequently, Dr. Ferrero conducted studies on the diagnosis and treatment of endometriosis using eutopic endometrial samples from patients with endometriosis, and heterologous and homologous animal model of this disease.

As a researcher, Dr. Ferrero has published in leading reproductive journals, such as JCEM, Human Reproduction, Fertility and Sterility, Placenta, Biology of Reproduction, and presented in several national and international meetings in the field of Reproductive Medicine, including ESHRE (European Society of Human Reproduction and Embryology) and SRI (Society of Reproductive Investigation).

Dr. Ferrero also participates as researcher in competitive project-grants as emerging researcher (Valencian State Governments) and researcher (Spanish Ministry of Economy and Competitiveness), besides acting as regular reviewer in different international journals, such as Human Reproduction, and Fertility and Sterility.

Dr. Ferrero has been involved in teaching in postgraduate courses since 2009, in Human Reproduction Module form the Master’s Degree in Biotechnology of Assisted Human Reproduction. In addition, she is supervising a doctoral thesis on uterine fibroids, since 2016.

Formación

B.Sc.	University of Valencia, Spain (2006)
MSc in Biomedicine and Biotecnology	University of Alicante (2006-2008)
Fellowship	University of Cambridge, UK (2013)
PhD in Biotecnology	University of Valencia, Spain (2014)

Honores y reconocimientos

Sara Borrell Grant by Heath Institute Carlos III	2016-2019
PhD Extraordinary Award	2015
PFIS felowship Grant by Heath Institute Carlos III	2009-2013
SRI Travel Award for “NGS of oocytes from endometriosis patients reveals a differential transcriptomic pattern"	2019
Miguel Servet contract (CP20/00120) by Heath Institute Carlos III	2021-2026
SRI President’s Award for Proteomic Analysis of Extracellular Vesicles Secreted by Primary Endometrial Epithelial Cells fromvFertile Women Reveals Functions Related to Embryo Implantation Not Present in an Endometrial Epithelial Cell Line	2021
Exemplary reviewer Award by Fertility and Sterility	2018

Publicaciones

H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/β-catenin and TGF-β pathways.
Carbajo-García MC, Juarez-Barber E, Segura-Benítez M, Faus A, Trelis A, Monleón J, Carmona-Antoñanzas G, Pellicer A, Flanagan JM, Ferrero H

Reprod Biol Endocrinol. 2023 Jan 26;21(1):9. doi: 10.1186/s12958-023-01060-2.. 2023 doi:

Deciphering the Role of Histone Modifications in Uterine Leiomyoma: Acetylation of H3K27 Regulates the Expression of Genes Involved in Proliferation, Cell Signaling, Cell Transport, Angiogenesis and Extracellular Matrix Formation.
Carbajo-García MC, de Miguel-Gómez L, Juárez-Barber E, Trelis A, Monleón J, Pellicer A, Flanagan JM, Ferrero H

Biomedicines.. May. 2022 doi: 10.3390/biomedicines10061279.

Integrative analysis of the DNA methylome and transcriptome in uterine leiomyoma shows altered regulation of genes involved in metabolism, proliferation, extracellular matrix and vesicles.
Carbajo-García MC, Corachán A, Juárez-Barber E, Monleón J, Payá V, Trelis A, Quiñonero A, Pellicer A, Ferrero H

J Pathol. 2022 Apr 26. Online ahead of print. 2022 doi: 10.1002/path.5920

Establishment of Adenomyosis Organoids as a Preclinical Model to Study Infertility.
Juárez-Barber E, Francés-Herrero E, Corachán A, Vidal C, Giles J, Alamá P, Faus A, Pellicer A, Cervelló I, Ferrero H

J Pers Med. 2022 doi: 10.3390/jpm12020219

Bioengineered Endometrial Hydrogels with Growth Factors Promote Tissue Regeneration and Restore Fertility in Murine Models.
López-Martínez S, Rodríguez-Eguren A, de Miguel-Gómez L, Francés-Herrero E, Faus A, Díaz A, Pellicer A, Ferrero H, Cervelló I

Acta Biomater. 2021 doi:

Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis.
Farahani ZK, Taherianfard M, Naderi MM, Ferrero H

Physiol Rep. 2021 doi:

Proteomic analysis of extracellular vesicles secreted by primary human epithelial endometrial cells reveals key proteins related to embryo implantation.
Segura-Benítez M, Carbajo-García MC, Corachán A, Faus A, Pellicer A, Ferrero H

Reprod Biol Endocrinol. 2021 doi:

5-aza-2'-deoxycitidine inhibits cell proliferation, extracellular matrix formation and Wnt/β-catenin pathway in human uterine leiomyomas.
Carbajo-Garcia MC, Corachan A, Segura-Benitez M, Monleon J, Escrig J, Faus A, Pellicer A, Cervello I, Ferrero H

Reprod Biol Endocr. 2021 doi:

Improved Models of Human Endometrial Organoids Based on Hydrogels from Decellularized Endometrium.
Frances-Herrero E, Juarez-Barber E, Campo H, Lopez-Martinez S, de Miguel-Gomez L, Faus A, Pellicer A, Ferrero H, Cervello I

J Pers Med. Jun. 2021 doi: 10.3390/jpm11060504

Novel therapeutic targets to improve IVF outcomes in endometriosis patients: a review and future prospects.
Corachan A, Pellicer N, Pellicer A, Ferrero H

Hum Reprod Update. Apr. 2021 doi: 10.1093/humupd/dmab014

A Natural Xenogeneic Endometrial Extracellular Matrix Hydrogel Toward Improving Current Human in vitro Models and Future in vivo Applications.
Lopez-Martínez S, Campo H, de Miguel-Gomez L, Faus A, Navarro AT, Díaz A, Pellicer A, Ferrero H, Cervello I

Front Bioeng Biotechnol. 2021 Mar. doi: 10.3389/fbioe.2021.639688

A Natural Xenogeneic Endometrial Extracellular Matrix Hydrogel Toward Improving Current Human in vitro Models and Future in vivo Applications
Lopez-Martinez S, Campo H, de Miguel-Gomez L, Faus A, Navarro A T, Diaz A, Pellicer A, Ferrero H, Cervello I,

Front Bioeng Biotechnol. 2021 Mar. doi: 10.3389/fbioe.2021.639688

Vitamin D as an effective treatment in human uterine leiomyomas independent of mediator complex subunit 12 mutation
Corachan A, Trejo M G, Carbajo-Garcia M C, Monleon J, Escrig J, Faus A, Pellicer A, Cervello I, Ferrero H,

Fertil Steril. 2021 Feb. doi: 10.1016/j.fertnstert.2020.07.049

Commentary on regulation of leiomyoma stem cell proliferation by WNT4 via AKT-dependent beta-Catenin activation
Ferrero H,

Fertil Steril. 2020 Dec. doi: 10.1016/j.fertnstert.2020.09.148

HMGA2 involvement in uterine leiomyomas development through angiogenesis activation
Ferrero H,

Fertil Steril. 2020 Nov. doi: 10.1016/j.fertnstert.2020.07.044

Stem cell paracrine actions in tissue regeneration and potential therapeutic effect in human endometrium: a retrospective study
de Miguel-Gomez L, Ferrero H, Lopez-Martinez S, Campo H, Lopez-Perez N, Faus A, Hervas D, Santamaria X, Pellicer A, Cervello I,

BJOG. 2020 Apr. doi: 10.1111/1471-0528.16078

Long-term vitamin D treatment decreases human uterine leiomyoma size in a xenograft animal model
Corachan A, Ferrero H, Escrig J, Monleon J, Faus A, Cervello I, Pellicer A,

Fertil Steril. 2020 Jan. doi: 10.1016/j.fertnstert.2019.09.018

Inhibition of KIF20A by BKS0349 reduces endometriotic lesions in a xenograft mouse model
Ferrero H, Corachan A, Quinonero A, Bougeret C, Pouletty P, Pellicer A, Dominguez F,

Mol Hum Reprod. 2019 1-Sep. doi: 10.1093/molehr/gaz044

Single-cell RNA sequencing of oocytes from ovarian endometriosis patients reveals a differential transcriptomic profile associated with lower quality
Ferrero H, Corachan A, Aguilar A, Quinonero A, Carbajo-Garcia M C, Alama P, Tejera A, Taboas E, Munoz E, Pellicer A, Dominguez F,

Hum Reprod. 2019 8-Jul. doi: 10.1093/humrep/dez053

Growth disparities in uterine leiomyomas associated with MED12 mutation
Ferrero H,

Fertil Steril. 2019 Jan. doi: 10.1016/j.fertnstert.2018.10.022

Inhibition of tumor cell proliferation in human uterine leiomyomas by vitamin D via Wnt/beta-catenin pathway
Corachan A, Ferrero H, Aguilar A, Garcia N, Monleon J, Faus A, Cervello I, Pellicer A,

Fertil Steril. 2019 Feb. doi: 10.1016/j.fertnstert.2018.10.008

Human Endometrial Reconstitution From Somatic Stem Cells: The Importance of Niche-Like Cells
Lopez-Perez N, Gil-Sanchis C, Ferrero H, Faus A, Diaz A, Pellicer A, Cervello I, Simon C,

Reprod Sci. 2019 Jan. doi: 10.1177/1933719118766251

Evaluation of PAI-1 in endometriosis using a homologous immunocompetent mouse model
Buigues A, Ferrero H, Martinez J, Pellicer N, Pellicer A, Gomez R,

Biol Reprod. 2018 Aug 1. doi: 10.1093/biolre/ioy057

Dysregulated genes and their functional pathways in luteinized granulosa cells from PCOS patients after cabergoline treatment
Ferrero H, Diaz-Gimeno P, Sebastian-Leon P, Faus A, Gomez R, Pellicer A,

Reproduction. 2018 Apr. doi: 10.1530/REP-18-0027

A novel homologous model for noninvasive monitoring of endometriosis progression
Ferrero H, Buigues A, Martinez J, Simon C, Pellicer A, Gomez R,

Biol Reprod. 2017 1-Feb. doi: 10.1095/biolreprod.116.140756

Evaluation of the antiproliferative, proapoptotic, and antiangiogenic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of leiomyoma
Garcia-Pascual C M, Ferrero H, Juarez I, Martinez J, Villanueva A, Pozuelo-Rubio M, Soengas M, Tormo D, Simon C, Gomez R, Pellicer A,

Fertil Steril. 2016 Feb. doi: 10.1016/j.fertnstert.2015.10.037

Dopamine agonist inhibits vascular endothelial growth factor protein production and secretion in granulosa cells
Ferrero H, Garcia-Pascual C M, Pellicer N, Simon C, Pellicer A, Gomez R,

Reprod Biol Endocrinol. 2015 17-Sep. doi: 10.1186/s12958-015-0102-4

Evaluation of the potential therapeutic effects of a double-stranded RNA mimic complexed with polycations in an experimental mouse model of endometriosis
Garcia-Pascual C M, Martinez J, Calvo P, Ferrero H, Villanueva A, Pozuelo-Rubio M, Soengas M, Tormo D, Simon C, Pellicer A, Gomez R,

Fertil Steril. 2015 Nov. doi: 10.1016/j.fertnstert.2015.07.1147

Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in an ovarian hyperstimulation syndrome (OHSS) animal model: implications for treatment of OHSS with dopamine receptor 2 agonists
Ferrero H, Garcia-Pascual C M, Gaytan M, Morales C, Simon C, Gaytan F, Pellicer A, Gomez R,

Fertil Steril. 2014 Nov. doi: 10.1016/j.fertnstert.2014.07.1240

Inhibition of Delta-like 4 mediated signaling induces abortion in mice due to deregulation of decidual angiogenesis
Garcia-Pascual C M, Ferrero H, Zimmermann R C, Simon C, Pellicer A, Gomez R,

Placenta. 2014 Jul. doi: 10.1016/j.placenta.2014.03.019

Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in vitro: implications for treatment of ovarian hyperstimulation syndrome with dopamine receptor 2 agonists
Ferrero H, Garcia-Pascual C M, Gomez R, Delgado-Rosas F, Cauli O, Simon C, Gaytan F, Pellicer A,

Fertil Steril. 2014 May. doi: 10.1016/j.fertnstert.2014.01.031

Efficiency and purity provided by the existing methods for the isolation of luteinized granulosa cells: a comparative study
Ferrero H, Delgado-Rosas F, Garcia-Pascual C M, Monterde M, Zimmermann R C, Simon C, Pellicer A, Gomez R,

Hum Reprod. 2012 Jun. doi: 10.1093/humrep/des096

The effects of ergot and non-ergot-derived dopamine agonists in an experimental mouse model of endometriosis
Delgado-Rosas F, Gomez R, Ferrero H, Gaytan F, Garcia-Velasco J A, Simon C, Pellicer A,

Reproduction. 2011 Nov. doi: 10.1530/REP-11-0223

Evidences for the existence of a low dopaminergic tone in polycystic ovarian syndrome: implications for OHSS development and treatment
Gomez R, Ferrero H, Delgado-Rosas F, Gaytan M, Morales C, Zimmermann R C, Simon C, Gaytan F, Pellicer A,

J Clin Endocrinol Metab. 2011 Aug. doi: 10.1210/jc.2011-0075

Presentaciones

Corachán A Trejo MG Carbajo-García MC Faus A Escrig J Monleón J Pellicer A Cervelló I Ferrero H Vitamin D as an effective treatment to reduce cell proliferation and extra cellular matrix formation in human uterine leiomyomas regardless MED12 mutation status.. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology, Copenhagen,Denmark, July 5-8, 2020

Corachán A Ferrero H Escrig J Monleón J Faus A Cervelló I Pellicer A O-208 VITAMIN D LONG-TERM TREATMENT DECREASES HUMAN UTERINE LEIOMYOMA SIZE THROUGH SPECIFIC MOLECULAR MECHANISMS IN A XENOGRAFT ANIMAL MODEL. Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology, Vienna, Austria, 14-16 October 2019

López Martínez S Campo H De Miguel-Gómez L Faus A Ferrero H Cervelló I O-121: Improving three-dimensional in vitro culture methods of human endometrial stem cells: bioengineering tissue-specific hydrogels. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver, CO, USA, 23-26 June 2019

De Miguel Gómez L López Martínez S Faus A Hervás D Ferrero H Cervelló I P-790: Stem cell therapy induces a shift from an inflammatory environment towards an immune tolerant scenario promoting endometrial tissue regeneration. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver, CO, USA, 23-26 June 2019

Ferrero H Corachán A Quiñonero A Bougeret C Pellicer A Dominguez F . P-315: Inhibition of KIF20A reduces endometriosis implants in a randomized xenograft mouse model. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver, CO, USA, 23-26 June 2019

Corachán A Ferrero H Escrig J Monleón J Faus A Cervelló I Pellicer A Eects of Vitamin D in Human Uterine Leiomyoma Growth in a Xenograft Animal Model.. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona, Spain, March 12-16, 2019

Ferrero H Corachán A Quiñonero A Carbajo-García C Alamá P Tejera A Taboas E Muñoz E Pellicer A Domínguez F NGS of Oocytes from Endometriosis Patients Reveals a Differential Transcriptomic Pattern. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona, Spain, March 12-16, 2019

Corachán A Ferrero H Aguilar A García N Monleón J Faus A Galiano D Cervelló I Pellicer A Vitamin D can inhibit proliferation of uterine fibroid cells in vitro through the Wnt/?-Catenin signalling pathway. , , July 2-5 ,2017

García N Aguilar A Corachán A Monleón J Ferrero H Galiano D Navarro AT Cervelló I Pellicer A In vitro proliferation of uterine fibroids is related with vitamin D receptor and patient´s age. , , July 2-5 ,2017

Investigación en Fertilidad

NUESTROS INVESTIGADORES

Biografía

Formación

Honores y reconocimientos

Publicaciones

Presentaciones