Irene Cervelló, Ph.D.

Biografía

Dr. Irene Cervelló, a full-time investigator at FIVI-IIS La Fe (Miguel Servet researcher granted by the Instituto de Salud Carlos III, ISCIII), is the Laboratory Manager and Leader of the Endometrial Stem Cell and Bioengineering Research Group at the FIVI Research Department (Valencia, Spain). Irene Cervelló obtained her doctorate in Biological Sciences, where she was trained to focus on Cell Biology, Somatic Stem Cells, and Reproductive Medicine. In 2008, she was awarded an extraordinary doctorate degree by the University of Valencia for a work that described stem cells in the human and mouse endometrium. Her research group has recently developed therapeutic approaches using bioengineering and cell treatments to treat uterine and endometrial pathologies. She became a co-inventor of the patent ‘Stem Cell Therapy for Endometrial Pathologies’ in 2014, using stem cells to cure endometrial disorders.

Her work has been published in more than 60 articles in different scientific journals, such as Human Reproduction, Human Reproduction Update, PLoS ONE, Fertility and Sterility, Acta Biomaterialia etc. She has been responsible for the supervision of eight doctoral theses in the last 12 years. She has been involved in numerous national and international congresses (with over 80 accepted presentations) in the field of gynaecological research and has been recognized with several awards (President´s Presenter Award at the Annual Meeting of the Society for Reproductive Investigation /SRI in 2009 and 2023; and the Oral Presentation Basic Science Award in 2012 at the Annual Meeting of the European Society of Human Reproduction and Embriology/ESHRE). Dr. Cervelló has participated as Principal Investigator in competitive projects both as emerging researcher (Generalitat Valenciana), and as lead researcher (ISCIII Projects).

Irene holds the position of Professor and Coordinator in the Master’s Degree in Biotechnology of Assisted Human Reproduction at the University of Valencia. In 2013 and 2019, she collaborated as post-doctoral researcher in North America at the Wake Forest Institute for Regenerative Medicine (5 months, Winston-Salem, North Caroline) and the Feinberg School of Medicine at the Northwestern University (4 months, Chicago, Illinois) been financed by the Ministry of Education (Spain). During 2023, she worked as a research collaborator at the Laboratory of Development of the Gonads at Université Paris Saclay for five months (granted by ISCIII).

Currently Dr. Cervelló serves as Membership & Nominations Committee member since 2023 for the Society for Reproductive Investigation (SRI) and as a ESHRE (European Society for Human Reproduction and Embriology) Committee of National Representative (CNR) for the 2023-2026 years.

Formación

B.Sc.	University of Valencia, Spain (2000)
Ph.D (Biology)	University of Valencia, Spain (2008)
Fellowship	Principe Felipe Research Center, Spain (2010-2011)
Fellowship	Wake Forest University, Wake Forest Institute for Regenerative Medicine /WFIRM (North Carolina), USA (2013)
Fellowship	Feinberg School of Medicine (Chicago) granted by the Spanish ministry of science, USA (2019)
Research Collaborator	Laboratory of Development of the Gonads at Université Paris Saclay (Paris) granted by Instituto de Salud Carlos III (ISCIII) (2023)

Honores y reconocimientos

University of Valencia School of Medicine, Spain, Scholarship for pre-doctoral training	(2003-2005)
IVI Foundation (Spain) Scholarship for pre-doctoral training	(2005-2006)
Ministry of Education (Spain)-Equipo IVI pre-doctoral contract	(2007-2008)
Extraordinary PhD Thesis Award, University of Valencia (Spain)	(2008)
President’s Presenter Award, Society for Reproductive Investigation (formerly Society for Gynecologic Investigation) (SRI)	(2009)
Basic Science Award, European Society of Human Reproduction and Embryology (ESHRE)	(2012)
President’s Presenter Award, Society for Reproductive Investigation (formerly Society for Gynecologic Investigation) (SRI)	2023
Member of Membership & Nominations Committee of SRI	since 2023
Member of ESHRE Committee of National Representatives	2023-2026

Publicaciones

Evolution of biotechnological advances and regenerative therapies for endometrial disorders: a systematic review.
Rodríguez-Eguren A, Bueno-Fernandez C, Gómez-Álvarez M, Francés-Herrero E, Pellicer A, Bellver J, Seli E, Cervelló I

Hum Reprod Update. 2024 May 25:dmae013. doi: 10.1093/humupd/dmae013. Online ahead of print.. 2024 doi:

Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders.
Juárez-Barber E, Corachán A, Carbajo-García MC, Faus A, Vidal C, Giles J, Pellicer A, Cervelló I, Ferrero H

Reprod Biol Endocrinol. 2024 Jan 9;22(1):10. doi: 10.1186/s12958-023-01182-7.. 2024 doi:

Addressing Key Questions in Organoid Models: Who, Where, How, and Why?
Gómez-Álvarez M, Agustina-Hernández M, Francés-Herrero E, Rodríguez-Eguren A, Bueno-Fernandez C, Cervelló I

Int J Mol Sci. 2023 Nov 6;24(21):16014. doi: 10.3390/ijms242116014.. 2023 doi:

Hybrid Endometrial-Derived Hydrogels: Human Organoid Culture Models and In Vivo Perspectives.
Gómez-Álvarez M, Bueno-Fernandez C, Rodríguez-Eguren A, Francés-Herrero E, Agustina-Hernández M, Faus A, Roca FG, Martínez-Ramos C, Galán A, Pellicer A, Ferrero H, Cervelló I

Adv Healthc Mater. 2023 Nov 20:e2303838. doi: 10.1002/adhm.202303838. Online ahead of print.. 2023 doi:

A biomechanical assessment of tissue-engineered polymer neo-uteri after orthotopic implantation.
Nordberg RC, Magalhaes RS, Cervelló I, Williams JK, Atala A, Loboa EG

F S Sci. 2023 Dec 23:S2666-335X(23)00076-9. doi: 10.1016/j.xfss.2023.12.005. Online ahead of print.. 2023 doi:

Bioengineering trends in female reproduction: a systematic review.
Francés-Herrero E, Lopez R, Hellström M, de Miguel-Gómez L, Herraiz S, Brännström M, Pellicer A, Cervelló I

Hum Reprod Update. 2022 Jun 2:dmac025. Online ahead of print. 2022 doi: 10.1093/humupd/dmac025

Establishment of Adenomyosis Organoids as a Preclinical Model to Study Infertility.
Juárez-Barber E, Francés-Herrero E, Corachán A, Vidal C, Giles J, Alamá P, Faus A, Pellicer A, Cervelló I, Ferrero H

J Pers Med. 2022 doi: 10.3390/jpm12020219

Human umbilical cord platelet-rich plasma to treat endometrial pathologies: methodology, composition and pre-clinical models.
Rodríguez-Eguren A, de Miguel-Gómez L, Francés-Herrero E, Gómez-Álvarez M, Faus A, Gómez-Cerdá M, Moret-Tatay I, Díaz A, Pellicer A, Cervelló I

Hum Reprod Open. 2022 Nov 28;2023(1):hoac053. doi: 10.1093/hropen/hoac053. eCollection 2023. . 2022 doi:

Predicted COVID-19 molecular effects on endometrium reveal key dysregulated genes and functions.
Henarejos-Castillo I, Devesa-Peiro A, de Miguel-Gomez L, Sebastian-Leon P, Romeu M, Aleman A, Molina-Gil C, Pellicer A, Cervello I, Diaz-Gimeno P

Mol Hum Reprod. 2022 Oct 7:gaac035. doi: 10.1093/molehr/gaac035. Online ahead of print.. 2022 doi:

Bioengineered Endometrial Hydrogels with Growth Factors Promote Tissue Regeneration and Restore Fertility in Murine Models.
López-Martínez S, Rodríguez-Eguren A, de Miguel-Gómez L, Francés-Herrero E, Faus A, Díaz A, Pellicer A, Ferrero H, Cervelló I

Acta Biomater. 2021 doi:

Presentaciones

Corachán A Trejo MG Carbajo-García MC Faus A Escrig J Monleón J Pellicer A Cervelló I Ferrero H Vitamin D as an effective treatment to reduce cell proliferation and extra cellular matrix formation in human uterine leiomyomas regardless MED12 mutation status.. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology, Copenhagen,Denmark, July 5-8,2020

Corachán A Ferrero H Escrig J Monleón J Faus A Cervelló I Pellicer A O-208 VITAMIN D LONG-TERM TREATMENT DECREASES HUMAN UTERINE LEIOMYOMA SIZE THROUGH SPECIFIC MOLECULAR MECHANISMS IN A XENOGRAFT ANIMAL MODEL. Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology, Vienna,Austria, 14-16 October 2019

López Martínez S Campo H De Miguel-Gómez L Faus A Ferrero H Cervelló I O-121: Improving three-dimensional in vitro culture methods of human endometrial stem cells: bioengineering tissue-specific hydrogels. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver,CO,USA, 23-26 June 2019

De Miguel Gómez L López Martínez S Faus A Hervás D Ferrero H Cervelló I P-790: Stem cell therapy induces a shift from an inflammatory environment towards an immune tolerant scenario promoting endometrial tissue regeneration. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver,CO,USA, 23-26 June 2019

Campo H García-Domínguez X López-Martínez S Antón J Marco-jiménez F Cervelló I Biomimetic Coatings from Decellularized Rabbit Endometrium Inuence the In Vitro In Vitro Development of PreImplantation Embryos. . Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona,Spain, March 12-16,2019

Corachán A Ferrero H Escrig J Monleón J Faus A Cervelló I Pellicer A Eects of Vitamin D in Human Uterine Leiomyoma Growth in a Xenograft Animal Model.. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona,Spain, March 12-16,2019

De Miguel-Gómez L Faus A López-Martínez S López-Pérez N Castillón G Pellicer A Cervelló I Human Platelet-Rich Plasma from Patients with Uterine Pathologies Contributes to Endometrial Regeneration: A Current Therapeutic Approach? . Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona,Spain, March 12-16,2019

López-Pérez N Santamaría X Díaz-Gimeno P Sebastian-Leon P Faus A Remohí J Pellicer A Simón C Cervelló I Stem Cell-Secreted Paracrine Factors in Human Endometrial Regeneration . Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology, Geneva,Switerland, March 6-10,2018

Corachán A Ferrero H Aguilar A García N Monleón J Faus A Galiano D Cervelló I Pellicer A Vitamin D can inhibit proliferation of uterine fibroid cells in vitro through the Wnt/?-Catenin signalling pathway. , , July 2-5 ,2017

García N Aguilar A Corachán A Monleón J Ferrero H Galiano D Navarro AT Cervelló I Pellicer A In vitro proliferation of uterine fibroids is related with vitamin D receptor and patient´s age. , , July 2-5 ,2017