Irene Cervello_FIVI_c

Irene Cervelló, Ph.D.

Laboratory Manager & Endometrial Stem Cell and Bioengineering Research Group Leader at the IVI Foundation Research Department

FIVI Valencia

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Irene Cervelló, Ph.D.

Biography

Dr. Irene Cervelló is a full-time investigator at FIVI-INCLIVA and Laboratory Manager & Endometrial Stem Cell and Bioengineering Research Group Leader at the IVI Foundation Research Department. She obtained her Bachelor’s degree in Biology in 2000, and her doctorate degree as “cum laude” with extraordinary prize in 2008, in the Pediatrics, Obstetrics and Gynaecology Department at the University of Valencia School of Medicine. During her post-doctoral training, she was a visiting scholar for five months at the Wake Forest Institute for Regenerative Medicine in North Carolina), USA, where she also performed tasks related to the revision of scientific articles and R&D project evaluations (Well Being of Women – ENGLAND and National Science Center-POLONIA).

As a researcher, her long time focus has been the identification, characterization and isolation of endometrial somatic stem cells and leiomyoma stem cells. More recently, her laboratory is developing therapeutic approaches to treat endometrial and uterine disorders using cell therapies and bioengineering.

Dr. Irene Cervello has participated as Principal Investigator in competitive projects both as emerging researcher (Generalitat Valenciana), and as lead researcher (FIS Projects 2018-2020). She published over 20 original articles in leading reproductive journals (Human Reproduction, Molecular Human Reproduction, Fertility and Sterility, Biology of Reproduction, PLoS One), and wrote six book chapters on somatic stem cells, reproductive medicine and bioengineering. Her research resulted in more than 40 scientific abstracts at international scientific meetings, including the European Society of Human Reproduction and Embryology (ESRHE), the Society for Gynaecologic Investigation (SGI now SRI) and the American Society for Reproductive Medicine (ASRM). Derived from her work using stem cells in endometrial pathologies she successfully registered the patent “Stem cell therapy in Endometrial Pathologies” in 2014 as a co-inventor.

Dr. Cervelló has been involved in teaching postgraduate courses since 2003. Presently, she is the coordinator of the Stem cells Section in Human Reproduction Module of the Master’s Degree in Biotechnology of Assisted Human Reproduction (University of Valencia School of Medicine). In addition, Dr. Cervello is currently the thesis advisor of two Ph.D. students (Generalitat Valenciana), and previously advised two graduate students who successfully completed their theses (one with European Extraordinary Prize of Doctorate).


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Education and Training

B.Sc. University of Valencia, Spain (2000)
Ph.D (Biology) University of Valencia, Spain (2008)
Fellowship Principe Felipe Research Center, Spain (2010-2011)
Fellowship Wake Forest University, Wake Forest Institute for Regenerative Medicine /WFIRM (North Carolina), USA (2013)

Honors and recognition

University of Valencia School of Medicine, Spain, Scholarship for pre-doctoral training (2003-2005)
IVI Foundation (Spain) Scholarship for pre-doctoral training (2005-2006)
Ministry of Education (Spain)-Equipo IVI pre-doctoral contract (2007-2008)
Extraordinary PhD Thesis Award, University of Valencia (Spain) (2008)
President’s Presenter Award, Society for Reproductive Investigation (formerly Society for Gynecologic Investigation) (SRI) (2009)
Basic Science Award, European Society of Human Reproduction and Embryology (ESHRE) (2012)
“José Castillejo” program grant for young researchers (Ministry of Education (Spain)) for postdoctoral training at the Wake Forest Institute for Regenerative Medicine (2013)

Publications


  • Bioengineering the Uterus: An Overview of Recent Advances and Future Perspectives in Reproductive Medicine.
    Campo H, Cervelló I, Simón C.
    Ann Biomed Eng, 45(7):1710-1717, 2017.

  • Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study.
    Santamaria X, Cabanillas S, Cervelló I, Arbona C, Raga F, Ferro J, Palmero J, Remohí J, Pellicer A, Simón C.
    Hum Reprod, 31(5):1087-96, 2016.

  • Translating Regenerative Medicine to the Clinic. Advances in Translational Medicine. Regenerative Medicine and Tissue Engineering in Reproductive Medicine: Future Clinical Applications in Human Infertility.
    Cervelló I, Medrano JV, Simón C.
    Elsevier Inc. 2016.

  • Human CD133(+) bone marrow-derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome.
    Cervelló I, Gil-Sanchis C, Santamaría X, Cabanillas S, Díaz A, Faus A, Pellicer A, Simón C.
    Fertil Steril, 104(6):1552-60, 2015.

  • Contribution of different bone marrow-derived cell types in endometrial regeneration using an irradiated murine model.
    Gil-Sanchis C, Cervelló I, Khurana S, Faus A, Verfaillie C, Simón C.
    Fertil Steril, 103(6):1596-605, 2015.

  • Overexpression of the truncated form of High Mobility Group A proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation.
    Mas A, Cervelló I, Fernández-Álvarez A, Faus A, Díaz A, Burgués O, Casado M, Simón C.
    Mol Hum Reprod, 21(4):330-8, 2015.


  • Cell Therapy and Tissue Engineering from and toward the Uterus.
    Cervelló I, Santamaría X, Miyazaki K, Maruyama T, Simón C
    Semin Reprod Med, 33(5):366-72, 2015.

  • Current understanding of somatic stem cells in leiomyoma formation.
    Mas A, Cervelló I, Gil-Sanchis C, Simón C.
    Fertil Steril, 102(3):613-20, 2014.

  • Tissue-derived mesenchymal stromal cells used as vehicles for anti-tumor therapy exert different in vivo effects on migration capacity and tumor growth.
    Belmar-Lopez C, Mendoza G, Oberg D, Burnet J, Simon C, Cervelló I, Iglesias M, Ramirez JC, Lopez-Larrubia P, Quintanilla M, Martin-Duque P.
    BMC Med, 11:139, 2013.

  • Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) as a putative human endometrial stem cell marker.
    Gil-Sanchis C, Cervelló I, Mas A, Faus A, Pellicer A, Simón C.
    Mol Hum Reprod, 19(7):407-14, 2013.

  • Somatic stem cells in the human endometrium.
    Cervelló I, Mas A, Gil-Sanchis C, Simón C.
    Semin Reprod Med, 31(1):69-76, 2013.

  • Stem Cells in Reproductive Medicine. Basic Science and Therapeutic Potential.
    Gargett CE, Cervelló I, Nguyen HTP, Simón C.
    Third Edition. Part 4 Chapter 11 Adult stem cells in the human endometrium. 2013.

  • Identification and characterization of the human leiomyoma side population as putative tumor-initiating cells.
    Mas A, Cervelló I, Gil-Sanchis C, Faus A, Ferro J, Pellicer A, Simón C.
    Fertil Steril, 98(3):741-751, 2012.

  • Bone marrow-derived cells from male donors do not contribute to the endometrial side population of the recipient.
    Cervelló I, Gil-Sanchis C, Mas A, Faus A, Sanz J, Moscardó F, Higueras G, Sanz MA, Pellicer A, Simón C.
    PLoS One, 7(1):e30260, 2012.

  • Reconstruction of endometrium from human endometrial side population cell lines.
    Cervelló I, Mas A, Gil-Sanchis C, Peris L, Faus A, Saunders PT, Critchley HO, Simón C.
    PLoS One, 6(6):e21221, 2011.

  • Stem cells in human endometrium and endometrial carcinoma.
    Cervelló I, Mirantes C, Santamaria X, Dolcet X, Matias-Guiu X, Simón C.
    Int J Gynecol Pathol, 30(4):317-27, 2011.

  • Human endometrial side population cells exhibit genotypic, phenotypic and functional features of somatic stem cells.
    Cervelló I, Gil-Sanchis C, Mas A, Delgado-Rosas F, Martínez-Conejero JA, Galán A, Martínez-Romero A, Martínez S, Navarro I, Ferro J, Horcajadas JA, Esteban FJ, O'Connor JE, Pellicer A, Simón C.
    PLoS One, 24;5(6):e10964, 2010.

  • Current understanding of Endometrial Stem cells.
    Cervelló I, Gil-Sanchis C, Mas A, Simón C.
    Expert Review of Obstetrics & Gynecology, Vol. 4(3), 2009.

  • Somatic stem cells in the endometrium.
    Cervelló I, Simón C.
    Reprod Sci, 16(2):200-5, 2009.

  • Stem Cells in Human reproduction. Basic Science and Therapeutic potential.
    Gargett CE, Cervelló I, Hubbard S, Simón C.
    Second Edition. Adult Stem Cells in the Human Endometrium. Informa Healthcare.2009.

  • Global Fertility Academy (GFA) Website. Research in Infertility
    Cervelló I.
    Chapter 8: Somatic Stem Cells from Endometrium, Myometrium and Testis. Juwi Mac Millan Group (“JuwiMM”). 2009.

  • El Endometrio Humano. Desde la Investigación a la Clínica. Células madre adultas en el endometrio.
    Cervelló I, Simón C.
    Editorial Medica Panamericana. 2009.

  • Identification, characterization and co-localization of label-retaining cell population in mouse endometrium with typical undifferentiated markers.
    Cervelló I, Martínez-Conejero JA, Horcajadas JA, Pellicer A, Simón C.
    Hum Reprod, 22(1):45-51, 2007.

  • Advances in Fertility studies and Reproductive Medicine.
    Cervelló I, Simón C.
    IFFS 2007. Adult Stem Cells in the Uterus. Besins Healthcare. 2007.


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Videos

Human CD133(+) bone marrow derived stem cells promote endometrial proliferation...
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