Irene Cervelló, Ph.D.

Biography

Dr. Irene Cervelló is a full-time investigator at FIVI-INCLIVA and Laboratory Manager & Endometrial Stem Cell and Bioengineering Research Group Leader at the IVI Foundation Research Department. She obtained her Bachelor’s degree in Biology in 2000, and her doctorate degree as “cum laude” with extraordinary prize in 2008, in the Pediatrics, Obstetrics and Gynaecology Department at the University of Valencia School of Medicine. During her post-doctoral training, she was a visiting scholar for five months at the Wake Forest Institute for Regenerative Medicine in North Carolina), USA, where she also performed tasks related to the revision of scientific articles and R&D project evaluations (Well Being of Women – ENGLAND and National Science Center-POLONIA).

As a researcher, her long time focus has been the identification, characterization and isolation of endometrial somatic stem cells and leiomyoma stem cells. More recently, her laboratory is developing therapeutic approaches to treat endometrial and uterine disorders using cell therapies and bioengineering.

Dr. Irene Cervello has participated as Principal Investigator in competitive projects both as emerging researcher (Generalitat Valenciana), and as lead researcher (FIS Projects 2018-2020). She published over 20 original articles in leading reproductive journals (Human Reproduction, Molecular Human Reproduction, Fertility and Sterility, Biology of Reproduction, PLoS One), and wrote six book chapters on somatic stem cells, reproductive medicine and bioengineering. Her research resulted in more than 40 scientific abstracts at international scientific meetings, including the European Society of Human Reproduction and Embryology (ESRHE), the Society for Gynaecologic Investigation (SGI now SRI) and the American Society for Reproductive Medicine (ASRM). Derived from her work using stem cells in endometrial pathologies she successfully registered the patent “Stem cell therapy in Endometrial Pathologies” in 2014 as a co-inventor.

Dr. Cervelló has been involved in teaching postgraduate courses since 2003. Presently, she is the coordinator of the Stem cells Section in Human Reproduction Module of the Master’s Degree in Biotechnology of Assisted Human Reproduction (University of Valencia School of Medicine). In addition, Dr. Cervello is currently the thesis advisor of two Ph.D. students (Generalitat Valenciana), and previously advised two graduate students who successfully completed their theses (one with European Extraordinary Prize of Doctorate).

Education and Training

B.Sc.	University of Valencia, Spain (2000)
Ph.D (Biology)	University of Valencia, Spain (2008)
Fellowship	Principe Felipe Research Center, Spain (2010-2011)
Fellowship	Wake Forest University, Wake Forest Institute for Regenerative Medicine /WFIRM (North Carolina), USA (2013)

Honors and recognition

University of Valencia School of Medicine, Spain, Scholarship for pre-doctoral training	(2003-2005)
IVI Foundation (Spain) Scholarship for pre-doctoral training	(2005-2006)
Ministry of Education (Spain)-Equipo IVI pre-doctoral contract	(2007-2008)
Extraordinary PhD Thesis Award, University of Valencia (Spain)	(2008)
President’s Presenter Award, Society for Reproductive Investigation (formerly Society for Gynecologic Investigation) (SRI)	(2009)
Basic Science Award, European Society of Human Reproduction and Embryology (ESHRE)	(2012)
“José Castillejo” program grant for young researchers (Ministry of Education (Spain)) for postdoctoral training at the Wake Forest Institute for Regenerative Medicine	(2013)

Publications

Predicted COVID-19 molecular effects on endometrium reveal key dysregulated genes and functions.
Henarejos-Castillo I, Devesa-Peiro A, de Miguel-Gomez L, Sebastian-Leon P, Romeu M, Aleman A, Molina-Gil C, Pellicer A, Cervello I, Diaz-Gimeno P

Mol Hum Reprod. 2022 Oct 7:gaac035. doi: 10.1093/molehr/gaac035. Online ahead of print.. 2022 doi:

Human umbilical cord platelet-rich plasma to treat endometrial pathologies: methodology, composition and pre-clinical models.
Rodríguez-Eguren A, de Miguel-Gómez L, Francés-Herrero E, Gómez-Álvarez M, Faus A, Gómez-Cerdá M, Moret-Tatay I, Díaz A, Pellicer A, Cervelló I

Hum Reprod Open. 2022 Nov 28;2023(1):hoac053. doi: 10.1093/hropen/hoac053. eCollection 2023. . 2022 doi:

Bioengineering trends in female reproduction: a systematic review.
Francés-Herrero E, Lopez R, Hellström M, de Miguel-Gómez L, Herraiz S, Brännström M, Pellicer A, Cervelló I

Hum Reprod Update. 2022 Jun 2:dmac025. Online ahead of print. 2022 doi: 10.1093/humupd/dmac025

Establishment of Adenomyosis Organoids as a Preclinical Model to Study Infertility.
Juárez-Barber E, Francés-Herrero E, Corachán A, Vidal C, Giles J, Alamá P, Faus A, Pellicer A, Cervelló I, Ferrero H

J Pers Med. 2022 doi: 10.3390/jpm12020219

Bioengineered Endometrial Hydrogels with Growth Factors Promote Tissue Regeneration and Restore Fertility in Murine Models.
López-Martínez S, Rodríguez-Eguren A, de Miguel-Gómez L, Francés-Herrero E, Faus A, Díaz A, Pellicer A, Ferrero H, Cervelló I

Acta Biomater. 2021 doi:

Presentations

Corachán A Trejo MG Carbajo-García MC Faus A Escrig J Monleón J Pellicer A Cervelló I Ferrero H Vitamin D as an effective treatment to reduce cell proliferation and extra cellular matrix formation in human uterine leiomyomas regardless MED12 mutation status.. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology, Copenhagen,Denmark, July 5-8,2020

Corachán A Ferrero H Escrig J Monleón J Faus A Cervelló I Pellicer A O-208 VITAMIN D LONG-TERM TREATMENT DECREASES HUMAN UTERINE LEIOMYOMA SIZE THROUGH SPECIFIC MOLECULAR MECHANISMS IN A XENOGRAFT ANIMAL MODEL. Presented at the 35th annual meeting of the European Society of Human Reproduction and Embryology, Vienna,Austria, 14-16 October 2019

López Martínez S Campo H De Miguel-Gómez L Faus A Ferrero H Cervelló I O-121: Improving three-dimensional in vitro culture methods of human endometrial stem cells: bioengineering tissue-specific hydrogels. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver,CO,USA, 23-26 June 2019

De Miguel Gómez L López Martínez S Faus A Hervás D Ferrero H Cervelló I P-790: Stem cell therapy induces a shift from an inflammatory environment towards an immune tolerant scenario promoting endometrial tissue regeneration. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver,CO,USA, 23-26 June 2019

Campo H García-Domínguez X López-Martínez S Antón J Marco-jiménez F Cervelló I Biomimetic Coatings from Decellularized Rabbit Endometrium Inuence the In Vitro In Vitro Development of PreImplantation Embryos. . Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona,Spain, March 12-16,2019

Corachán A Ferrero H Escrig J Monleón J Faus A Cervelló I Pellicer A Eects of Vitamin D in Human Uterine Leiomyoma Growth in a Xenograft Animal Model.. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona,Spain, March 12-16,2019

De Miguel-Gómez L Faus A López-Martínez S López-Pérez N Castillón G Pellicer A Cervelló I Human Platelet-Rich Plasma from Patients with Uterine Pathologies Contributes to Endometrial Regeneration: A Current Therapeutic Approach? . Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona,Spain, March 12-16,2019

López-Pérez N Santamaría X Díaz-Gimeno P Sebastian-Leon P Faus A Remohí J Pellicer A Simón C Cervelló I Stem Cell-Secreted Paracrine Factors in Human Endometrial Regeneration . Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology, Geneva,Switerland, March 6-10,2018

Corachán A Ferrero H Aguilar A García N Monleón J Faus A Galiano D Cervelló I Pellicer A Vitamin D can inhibit proliferation of uterine fibroid cells in vitro through the Wnt/?-Catenin signalling pathway. , , July 2-5 ,2017

García N Aguilar A Corachán A Monleón J Ferrero H Galiano D Navarro AT Cervelló I Pellicer A In vitro proliferation of uterine fibroids is related with vitamin D receptor and patient´s age. , , July 2-5 ,2017