Christian Simon Ottolini

Biography

Dr Christian Simon Ottolini, PhD, is an accomplished expert in embryology and reproductive genetics. After completing his undergraduate studies and training as an embryologist in his native Australia, Dr Ottolini moved to London to advance his career in embryology and pursue a PhD in genetics. His research has mainly focussed on the origin of chromosomal abnormalities in human embryos, and his unique skill set has led to global collaborations with renowned researchers and the publication of several important papers describing novel biological phenomena.

Alongside his academic achievements, Dr Ottolini has worked as a clinical embryologist and laboratory director and has considerable experience setting up and running world class IVF facilities. He is known for his compassionate patient care and understanding the challenges individuals face when undergoing fertility treatment, always working hard to translate his research into tangible benefits for his patients and improve treatment outcomes.

Currently Dr Ottolini resides in Rome, Italy, and is Head of Embryology for Juno Genetics EU forming part of the Juno research team. He also currently holds an academic affiliation as an honorary research fellow in the department of Maternal and Foetal Medicine at UCL, UK.

Dr Ottolini is widely respected for his contributions in embryology and reproductive genetics and through his research, patient care, and commitment to education, he has both positively impacted individuals seeking fertility treatment and helped advance our understanding of reproductive genetics.

Publications

Investigating the significance of segmental aneuploidy findings in preimplantation embryos
Ludovica Picchetta, Christian S Ottolini, Helen C O'Neill, Antonio Capalbo

F S Sci. 2023 Mar 20:S2666-335X(23)00015-0. doi: 10.1016/j.xfss.2023.03.004. Online ahead of print.. 2023 doi:

Artificial oocyte activation with calcium ionophore does not cause a widespread increase in chromosome segregation errors in the second meiotic division of the oocyte.
Capalbo A, Ottolini CS, Griffin DK, Ubaldi FM, Handyside AH, Rienzi L

Fertil Steril. 2016 Mar;105(3):807-814.e2. doi: 10.1016/j.fertnstert.2015.11.017. Epub 2015 Dec 1.. 2016 doi:

Electronic witness system in IVF-patients perspective.
Forte M, Faustini F, Maggiulli R, Scarica C, Romano S, Ottolini C, Farcomeni A, Palagiano A, Capalbo A, Ubaldi FM, Rienzi L

J Assist Reprod Genet. 2016 Sep;33(9):1215-22. doi: 10.1007/s10815-016-0759-4. Epub 2016 Jul 7.. 2016 doi:

Generation of meiomaps of genome-wide recombination and chromosome segregation in human oocytes.
Ottolini CS, Capalbo A, Newnham L, Cimadomo D, Natesan SA, Hoffmann ER, Ubaldi FM, Rienzi L, Handyside AH

Nat Protoc. 2016 Jul;11(7):1229-43. doi: 10.1038/nprot.2016.075. Epub 2016 Jun 16.. 2016 doi:

Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates.
Ottolini CS, Newnham L, Capalbo A, Natesan SA, Joshi HA, Cimadomo D, Griffin DK, Sage K, Summers MC, Thornhill AR, Housworth E, Herbert AD, Rienzi L, Ubaldi FM, Handyside AH, Hoffmann ER

Nat Genet. 2015 Jul;47(7):727-735. doi: 10.1038/ng.3306. Epub 2015 May 18.. 2015 doi:

Karyomapping - a comprehensive means of simultaneous monogenic and cytogenetic PGD: comparison with standard approaches in real time for Marfan syndrome.
Thornhill, AR, Handyside, AH, Ottolini, C, Natesan, SA, Taylor, J, Sage, K, Harton, G, Cliffe, K, Affara, N, Konstantinidis, M, Wells, D, Griffin, DK,

J Assist Reprod Genet. 2015 doi:

Karyomapping identifies second polar body DNA persisting to the blastocyst stage: implications for embryo biopsy.
Ottolini, CS, Rogers, S, Sage, K, Summers, MC, Capalbo, A, Griffin, DK, Sarasa, J, Wells, D, Handyside, AH, Wells, D,

RBM Online. 2015 doi:

A cautionary note against embryo aneuploidy risk assessment using time-lapse imaging.
Ottolini C, Rienzi L, Capalbo A

Reprod Biomed Online. 2014 Mar;28(3):273-5. doi: 10.1016/j.rbmo.2013.10.015. Epub 2013 Oct 26.. 2014 doi:

Live birth after PGD with confirmation by a comprehensive approach (karyomapping) for simultaneous detection of monogenic and chromosomal disorders.
Natesan, SA, Handyside, AH, Thornhill, AR, Ottolini, CS, Sage, K, Summers, MC, Konstantinidis, M, Wells, D, Griffin, DK,

RBM Online. 2014 doi:

B.Sc. (Human Biology)	University of Western Australia (2005)
Ph.D. (Genetics)	University of Kent (2015)
DipRCPath (Reproductive Biology)	Royal College of Pathologists, UK (2021)

Fertility Researchers

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