Antonio Requena, M.D., Ph.D.

Biography

Dr. Antonio Requena, MD, is Assistant Professor at Rey Juan Carlos University in the Department of Obstetrics and Gynecology; Director Master’s Degree in Biology and Technology Applied to Assisted Human Reproduction IVI Madrid-European University of Madrid; Former Executive Manager of IVI Congress; IVI Madrid Director and Chief Medical Officer of IVIRMA Global. He graduated from the Complutense University of Madrid in Medicine and he completed his training in Gynecology and Obstetrics at the Autonoma University in Madrid.

He went on to pursue a pre-doctoral training in invitro oocyte maturation at John Eppig’s laboratory (Bar Harbour, Maine, USA) and finally he achieved his PhD in Medicine from Rey Juan Carlos University in Madrid. Dr. Requena completed his training by studying several masters: Management Development at ESADE Business School, Management Program in Health Institutions at IESE Business School and Innovation and Leadership in Fertility in IE Business School.

He has participated as a tutor in several projects financed by public entities, such as “Influence of glucose metabolism during oocyte maturation in cellular apoptosis. Clinical application in the diabeticpatient” at Autonoma University in Madrid.

He is active in the Spanish Society of Fertility (SEF) and also attends the European Society of Human Reproduction and Embryology (ESHRE).
Dr. Requena has been invited to speak nationally and internationally and has authored and contributed in over 40 peer reviewed publications, published chapters and abstracts. He also serves as Ad Hoc Reviewer for the Reproductive Biomedicine Online, Human Reproduction, Fertility and
Sterility, and as the editor for a textbook on Reproductive Medicine. His research interests include Endocrinology, Ovarian Stimulations, and genetics in Reproductive Medicine.

Education and Training

Graduated in Medicine	Complutense University (Madrid) (1989)
Pre-doctoral training in in-vitro oocyte maturation	John Eppig’s laboratory (Bar Harbour,Maine, USA) (1998)
Program of Management Development	(ESADE Business School) (2009)
PhD in Medicine	Rey Juan Carlos University (Madrid) (2014)
Advanced Management Program in Health Institutions	(IESE Business School) (2015)
Innovation and Leadership.	(IE Business School) (2016)

Publications

Impact of parental chromosomal polymorphisms on the incidence of congenital anomalies and perinatal complications in a cohort of newborns conceived after ICSI + PGT-A.
Rodriguez F Cruz M Requena A

Reprod Biol Endocrinol.. Sep. 2022 doi: 10.1186/s12958-022-01012-2.

Adenomyosis decreases the live birth rate but may not affect perinatal outcomes in assisted reproductive cycles.
Trinchant R, Cruz M, Requena A

Int J Gynaecol Obstet. 2022 May 6. Online ahead of print. 2022 doi: 10.1002/ijgo.14256

How to provide fertility treatment during COVID-19 pandemic.
Cruz M, Requena A

Curr Opin Obstet Gynecol. Mar. 2021 doi: 10.1097/GCO.0000000000000705

Impact of chronic endometritis in infertility: A SWOT analysis
Espinos JJ, Fabregues F, Fontes J, Garcia-Velasco J A, Llacer, Requena A, Checa MA, Bellver J, Spanish Infertility SWOT Group (SISG)

Reprod BioMed Online. Mar. 2021 doi: 10.1016/j.rbmo.2021.02.003

How to provide fertility treatment during COVID-19 pandemic
Cruz M, Requena A,

Curr Opin Obstet Gynecol. Jun. 2021 doi: 10.1097/GCO.0000000000000705

Impact of chronic endometritis in infertility: a SWOT analysis
Espinos J J, Fabregues F, Fontes J, Garcia-Velasco J A, Llacer J, Requena A, Checa M A, Bellver J, Spanish Infertility Swot Group,

Reprod Biomed Online. May. 2021 doi: 10.1016/j.rbmo.2021.02.003

ALWAYS ICSI? A SWOT analysis
Bosch E, Espinos J J, Fabregues F, Fontes J, Garcia-Velasco J A, Llacer J, Requena A, Checa M A, Bellver J, Spanish Infertility Swot Group,

J Assist Reprod Genet. Sep. 2020 doi: 10.1007/s10815-020-01836-0

Infertility and reproductive rights after the COVID-19 pandemic
Trinchant R M, Cruz M, Marqueta J, Requena A,

Reprod Biomed Online. Aug. 2020 doi: 10.1016/j.rbmo.2020.05.007

A picture of the covid-19 impact on IVIRMA fertility treatment clinics in Spain and Italy
Requena A, Cruz M, Vergara V, Prados N, Galliano D, Pellicer A,

Reprod Biomed Online. Jul. 2020 doi: 10.1016/j.rbmo.2020.04.015

ALWAYS ICSI A SWOT analysis.
Bosch E, Espinos JJ, Fabregues F, Fontes J, Garcia-Velasco J A, Llacer J, Requena A, Checa MA, Bellver J, Checa MA,

J Assist Reprod Genet. 2020 doi:

Donor IUI is equally effective for heterosexual couples, single women and lesbians, but autologous IUI does worse
Soares S R, Cruz M, Vergara V, Requena A, Garcia-Velasco J A,

Hum Reprod. 2019 1-Nov. doi: 10.1093/humrep/dez179

Use of granulocyte colony-stimulating factor in ART treatment does not increase the risk of adverse perinatal outcomes
Cruz M, Alecsandru D, Garcia-Velasco J A, Requena A,

Reprod Biomed Online. 2019 Dec. doi: 10.1016/j.rbmo.2019.09.008

Second-generation preimplantation genetic testing for aneuploidy in assisted reproduction: a SWOT analysis
Bellver J, Bosch E, Espinos J J, Fabregues F, Fontes J, Garcia-Velasco J A, Llacer J, Requena A, Checa M A, Spanish Infertility Swot Group,

Reprod Biomed Online. 2019 Dec. doi: 10.1016/j.rbmo.2019.07.037

Is the transport of frozen embryos a good option to improve results in a transnational oocyte donation program?
Requena A, Cruz M, Pellicer A,

Hum Reprod. 2019 8-Jul. doi: 10.1093/humrep/dez093

Hysteroscopic septum resection and reproductive medicine: A SWOT analysis
Spanish Infertility Swot Group, Checa M A, Bellver J, Bosch E, Espinos J J, Fabregues F, Fontes J, Garcia-Velasco J A, Requena A,

Reprod Biomed Online. 2018 Dec. doi: 10.1016/j.rbmo.2018.09.013

Small-sized follicles could contribute to high-order multiple pregnancies: outcomes of 6552 intrauterine insemination cycles
Giles J, Cruz M, Gonzalez-Ravina C, Caligara C, Prados N, Martinez J C, Vergara V, Requena A,

Reprod Biomed Online. 2018 Nov. doi: 10.1016/j.rbmo.2018.08.019

Type of gonadotropin used during controlled ovarian stimulation induces differential gene expression in human cumulus cells: A randomized study
Cruz M, Requena A, Agudo D, Garcia-Velasco J A,

Eur J Obstet Gynecol Reprod Biol. 2017 Aug. doi: 10.1016/j.ejogrb.2017.06.014

Economic impact of ovarian stimulation with corifollitropin alfa versus conventional daily gonadotropins in oocyte donors: a randomized study
Cruz M, Alama P, Muñoz M, Collado D, Blanes C, Solbes E, Requena A,

Reprod Biomed Online. 2017 Jun. doi: 10.1016/j.rbmo.2017.03.003

Adenomyosis in infertile women: prevalence and the role of 3D ultrasound as a marker of severity of the disease
Puente J M, Fabris A, Patel J, Patel A, Cerrillo M, Requena A, Garcia-Velasco J A,

Reprod Biol Endocrinol. 2016 20-Sep. doi: 10.1186/s12958-016-0185-6

Assisted reproductive techniques after fertility-sparing treatments in gynaecological cancers
Zapardiel I, Cruz M, Diestro M D, Requena A, Garcia-Velasco J A,

Hum Reprod Update. 2016 Apr. doi: 10.1093/humupd/dmv066

Type of gonadotropin during controlled ovarian stimulation affects the endocrine profile in follicular fluid and apoptosis rate in cumulus cells
Requena A, Cruz M, Agudo D, Pacheco A, Garcia-Velasco J A,

Eur J Obstet Gynecol Reprod Biol. 2016 Feb. doi: 10.1016/j.ejogrb.2015.12.018

Type of gonadotropin during controlled ovarian stimulation affects the endocrine profile in follicular fluid and apoptosis rate in cumulus cells.
Requena A, Cruz M, Agudo D, Pacheco A, Garcia-Velasco J A,

Eur J Obstet Gynecol Reprod Biol. 2016 doi:

Ongoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels
Requena A, Cruz M, Pacheco A, Garcia-Velasco J A,

Fertil Steril. 2015 Oct. doi: 10.1016/j.fertnstert.2015.06.026

Monozygotic twinning after assisted reproductive technologies: a case report of asymmetric development and incidence during 19 years in an international group of in vitro fertilization clinics
Tocino A, Blasco V, Prados N, Vargas M J, Requena A, Pellicer A, Fernandez-Sanchez M,

Fertil Steril. 2015 May. doi: 10.1016/j.fertnstert.2015.01.033

Maternal KIR haplotype influences live birth rate after double embryo transfer in IVF cycles in patients with recurrent miscarriages and implantation failure
Alecsandru D, Garrido N, Vicario J L, Barrio A, Aparicio P, Requena A, Garcia-Velasco J A,

Hum Reprod. 2014 Dec. doi: 10.1093/humrep/deu251

High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study
Requena A, Cruz M, Bosch E, Meseguer M, Garcia-Velasco J A,

Reprod Biol Endocrinol. 2014 26-Jul. doi: 10.1186/1477-7827-12-69

Endocrine profile following stimulation with recombinant follicle stimulating hormone and luteinizing hormone versus highly purified human menopausal gonadotropin
Requena A, Cruz M, Ruiz F J, Garcia-Velasco J A,

Reprod Biol Endocrinol. 2014 Jan 29. doi: 10.1186/1477-7827-12-10

Embryo aneuploidy screening with CGH arrays in the absence of implantation.
Garcia-Herrero S, Garcia-Herrero S, Rodrigo L, Mateu E, Peinado V, Milan M, Campos-Galindo I, Vera M, Mercader A, Bronet F, Requena A, Simon C, Rubio C, Vera M,

Médecine de la Reproduction. 2014 doi:

High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study.
Requena A, Cruz M, Bosch E, Meseguer M, Garcia-Velasco J A,

Reprod Biol Endocrinol 2014; 26:69. 2014 doi:

Maternal KIR haplotype influence life birth rate after embryo transfer in vitro fertilization (IVF) cycles.
Alecsandru D, Garrido N, Vicario J, Barrio A, Aparicio P, Requena A, Garcia-Velasco J A,

Hum Reprod. 2014 doi:

Evaluation of the degree of satisfaction in oocyte donors using sustained-release FSH corifollitropin ?.
Requena A, Cruz M, Collado D, Izquierdo A, Ballesteros A, Muñoz M, Garcia-Velasco J A,

RBM Online. 2013 doi:

Natural lh surge vs hCG triggered vs hormone replace treatment (HRT): do pregnancy rates differ?
Cerrillo M, Guillen A, Zapata A, Herrero I, Requena A, Garcia-Velasco J A,

Fertil Steril. 2013 doi:

Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: a retrospective cohort study
Meseguer M, Rubio I, Cruz M, Basile N, Marcos J, Requena A,

Fertil Steril. 2012 Dec. doi: 10.1016/j.fertnstert.2012.08.016

Efficacy and safety of human chorionic gonadotropin for follicular phase stimulation in assisted reproduction: a systematic review and meta-analysis
Checa M A, Espinos J J, Requena A,

Fertil Steril. 2012 Jun. doi: 10.1016/j.fertnstert.2012.02.049

Cycle scheduling with oral contraceptive pills in the GnRH antagonist protocol vs the long protocol: a randomized, controlled trial
Garcia-Velasco J A, Bermejo A, Ruiz F, Martinez-Salazar J, Requena A, Pellicer A,

Fertil Steril. 2011 Sep. doi: 10.1016/j.fertnstert.2011.06.022

GnRH analogue for the prevention of ovarian hyperstimulation syndrome: a pilot study.
Giles J, Requena A, Garcia-Velasco J A, Pacheco A, Pellicer J, Pellicer A,

Fertil Steril. 2009 doi:

Letrozole administration during the luteal phase after ovarian stimulation impacts corpus luteum function: a randomized, placebo-controlled trial.
Garcia-Velasco J A, Quea G, Piro M, Mayoral M, Ruiz M, Toribio M, Requena A,

Fertil Steril. 2009 doi:

The impact of in-vitro maturation of oocytes on aneuploidy rate.
Requena A, Bronet F, Guillen A, Agudo D, Bou C, Garcia-Velasco J A,

RBM Online. 2009 doi:

Use of letrozole in assisted reproduction: a systematic review and meta-analysis
Requena A, Herrero J, Landeras J, Navarro E, Neyro J L, Salvador C, Tur R, Callejo J, Checa M A, Farre M, Espinos J J, Fabregues F, Grana-Barcia M, Reproductive Endocrinology Interest Group of Spanish Society of Fertility,

Hum Reprod Update. 2008 Nov-Dec. doi: 10.1093/humupd/dmn033

Endocrine modifications associated with final oocyte maturation with gonadotropin-releasing hormone agonists vs. human chorionic gonadotropin in women undergoing intrauterine insemination
Diaz I, Guillen A, Pacheco A, Requena A, Garcia-Velasco J A,

J Reprod Med. 2008 Jan. doi:

Estradiol supplementation during the luteal phase of IVF-ICSI patients: a randomized, controlled trial
Serna J, Cholquevilque J L, Cela V, Martinez-Salazar J, Requena A, Garcia-Velasco J A,

Fertil Steril. 2008 Dec. doi: 10.1016/j.fertnstert.2007.10.021

Artículo de revisión "Diagnóstico por imagen”
Puente J M, Grañeras A, Requena A,

Cuadernos de Medicina Reproductiva. 2007 doi:

The aromatase inhibitor letrozole increases the concentration of intraovarian androgens and improves in vitro fertilization outcome in low responder patients: a pilot study
Garcia-Velasco J A, Moreno L, Pacheco A, Guillen A, Duque L, Requena A, Pellicer A,

Fertil Steril. 2005 Jul. doi: 10.1016/j.fertnstert.2005.01.117

Extended coasting duration exerts a negative impact on IVF cycle outcome due to premature luteinization
Moreno L, Diaz I, Pacheco A, Zuniga A, Requena A, Garcia-Velasco J A,

Reprod Biomed Online. 2004 Nov. doi: 10.1016/s1472-6483(10)61633-1

Recombinant vs. urinary follicle-stimulating hormone in couples undergoing intrauterine insemination. A randomized study
Isaza V, Requena A, Garcia-Velasco J A, Remohi J, Pellicer A, Simon C,

J Reprod Med. 2003 Feb. doi:

Transabdominal ultrasound-guided embryo transfer does not increase pregnancy rates in oocyte recipients
Garcia-Velasco J A, Isaza V, Martinez-Salazar J, Landazabal A, Requena A, Remohi J, Simon C,

Fertil Steril. 2002 Sep. doi: 10.1016/s0015-0282(02)03249-1

Transabdominal ultrasound-guided embryo transfer does not increase pregnancy rates in oocyte recipients.
Garcia-Velasco J A, Isaza V, Martinez-Salazar J, Landazabal A, Requena A, Remohi J, Simon C,

Fertil Steril. 2002 doi:

Endocrinological and ultrasonographic variations after immature oocyte retrieval in a natural cycle
Requena A, Neuspiller F, Cobo A, Aragones M, Garcia-Velasco J A, Remohi J, Simon C, Pellicer A,

Hum Reprod. 2001 Sep. doi: 10.1093/humrep/16.9.1833

High doses of gonadotrophins combined with stop versus non-stop protocol of GnRH analogue administration in low responder IVF patients: a prospective, randomized, controlled trial
Garcia-Velasco J A, Isaza V, Requena A, Martinez-Salazar F J, Landazabal A, Remohi J, Pellicer A, Simon C,

Hum Reprod. 2000 Nov. doi: 10.1093/humrep/15.11.2292

The potential use of maturation in vitro of human oocytes in low responder patients
Requena A, Neuspiller F, Cobo A, Aragones M, Remohi J, Simon C, Pellicer A,

J Assist Reprod Genet. 2000 May. doi: 10.1023/a:1009405730750

High doses of gonadotrophins combined with stop versus non-stop protocol of GnRH analogue administration in low responder IVF patients: a prospective, randomized, controlled trial.
Garcia-Velasco J A, Isaza V, Requena A, Martinez-Salazar FJ, Landazabal A, Remohi J, Pellicer A, Simon C,

Hum Reprod. 2000 doi:

Maternal serum creatine kinase: a possible predictor of tubal pregnancy?
Garcia-Velasco J A, Requena A, Santisteban J,

Am J Obstet Gynecol. 1996 doi:

Presentations

Klimczak AM Herlihy NS Kim JG Hanson BM Osman EK Tiegs AW Marie D Werner Kaser DJ Requena A Scott RT P-744 USE OF MEDROXYPROGESTERONE ACETATE (MPA) IN DONOR CYCLES DECREASES MEDICATION COSTS. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Prados N González-Ravina C Vergara V Javier Herrero Cruz M Requena A P-980 RISK FACTOR ANALYSIS FOR SARS-COV-2 SEROPOSITIVITY WITHIN ASSISTED REPRODUCTIVE. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Cruz M Vergara V Requena A P-857 TYPE OF FOLLITROPIN ALFA FOR OVARIAN STIMULATION WITH MEDROXYPROGESTERONE ACETATE DOES NOT AFFECT CLINICAL OUTCOMES IN A DONOR-RECIPIENT PROGRAM. Presented at 76th American Society of Reproductive Medicine Scientific Congress, Virtual congress, October 17-21,2020

Rodriguez Valderrama F Palomino MC Pla Victori J Requena A Chromosomal abnormalities in males, but not chromosomal polymorphisms, affect the preterm delivery rate in ICSI+PGT cycles. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology, Copenhagen,Denmark, July 5-8, 2020

María Cruz Hennzen E Requena A O-156 Pituitary supression is not necessary for blocking LH surge during luteal-phase stimulation. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology, Copenhagen,Denmark, July 5-8, 2020

González-Ravina Vergara V Cruz M Prados N Requena A O-146 Is COVID-19 symptomatic triage enough? The limited value of serological testing. Presented at the 36th annual meeting of the European Society of Human Reproduction and Embryology, Copenhagen,Denmark, July 5-8, 2020

Cruz M Alecsandru D Garcia Velasco J Requena A Use of granulocyte colony-stimulating factor during an assisted reproductive treatment does not increase the risk of birth defects. Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology, Geneva,Switerland, July 1-4,2018

Calonge M Garrido N Cobo A Gonzalez-Valdes F Morbeck D Requena A Troncoso C Quantifying the parameters affecting the success of egg donor program: A predictive model and optimization tool. , , July 2-5 ,2017

González-Ravina C Cruz M Rubio C Fernández-Sánchez M Oquiñena E Ferrando R Requena A Polymorphic chromosome variants, human inversions, and their functional consequences in male infertility. , , July 2-5 ,2017

Rubio Lluesa C Cruz M González-Ravina C Fernández-Sánchez M Oquiñena E Requena A Polymorphism on chromosome 21 does not affect ovarian reserve but clinical outcomes after in vitro fertilization treatments. , , July 2-5 ,2017

Sánchez M Pacheco A Cruz M Requena A Assessment of sperm ploidy status by flow cytommetry correlates to embryo quality 2017

Vergara Bravo V Cruz M Goyri E Requena A Pituitary suppression protocol does affect clinical outcomes in egg donation cycles 2017

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