Antonio Requena, M.D., Ph.D.

Chief Medical Officer of IVIRMA Global

IVI Madrid

Biography

Dr. Antonio Requena, MD, is Assistant Professor at Rey Juan Carlos University in the Department of Obstetrics and Gynecology; Director Master’s Degree in Biology and Technology Applied to Assisted Human Reproduction IVI Madrid-European University of Madrid; Former Executive Manager of IVI Congress; IVI Madrid Director and Chief Medical Officer of IVIRMA Global. He graduated from the Complutense University of Madrid in Medicine and he completed his training in Gynecology and Obstetrics at the Autonoma University in Madrid.

He went on to pursue a pre-doctoral training in invitro oocyte maturation at John Eppig’s laboratory (Bar Harbour, Maine, USA) and finally he achieved his PhD in Medicine from Rey Juan Carlos University in Madrid. Dr. Requena completed his training by studying several masters: Management Development at ESADE Business School, Management Program in Health Institutions at IESE Business School and Innovation and Leadership in Fertility in IE Business School.

He has participated as a tutor in several projects financed by public entities, such as “Influence of glucose metabolism during oocyte maturation in cellular apoptosis. Clinical application in the diabeticpatient” at Autonoma University in Madrid.

He is active in the Spanish Society of Fertility (SEF) and also attends the European Society of Human Reproduction and Embryology (ESHRE).
Dr. Requena has been invited to speak nationally and internationally and has authored and contributed in over 40 peer reviewed publications, published chapters and abstracts. He also serves as Ad Hoc Reviewer for the Reproductive Biomedicine Online, Human Reproduction, Fertility and
Sterility, and as the editor for a textbook on Reproductive Medicine. His research interests include Endocrinology, Ovarian Stimulations, and genetics in Reproductive Medicine.

Graduated in Medicine	Complutense University (Madrid) 1989
Pre-doctoral training in in-vitro oocyte maturation	John Eppig’s laboratory (Bar Harbour,Maine, USA) 1998
Program of Management Development	(ESADE Business School) 2009
PhD in Medicine	Rey Juan Carlos University (Madrid) 2014
Advanced Management Program in Health Institutions	(IESE Business School) 2015
Innovation and Leadership.	(IE Business School) 2016

Publications

Use of granulocyte colony-stimulating factor in ART treatment does not increase the risk of adverse perinatal outcomes.
Cruz M Alecsandru D García-Velasco JA Requena A
Reprod Biomed Online. 2019 Sep 19. pii: S1472-6483(19)30744-8. doi: 10.1016/j.rbmo.2019.09.008. [Epub ahead of print]

Donor IUI is equally effective for heterosexual couples, single women and lesbians, but autologous IUI does worse.
Soares SR Cruz M Vergara V Requena A García-Velasco JA
Hum Reprod. 2019 Nov 6. pii: dez179. doi: 10.1093/humrep/dez179. [Epub ahead of print]

Second-generation preimplantation genetic testing for aneuploidy in assisted reproduction: a SWOT analysis.
Bellver J Bosch E Espinós J García-Velasco JA Fabregues F Fontes J Llácer J Requena A Checa MA
Reprod Biomed Online. 2019 Aug 13. pii: S1472-6483(19)30695-9. doi: 10.1016/j.rbmo.2019.07.037. [Epub ahead of print] Review.

Is the transport of frozen embryos a good option to improve results in a transnational oocyte donation program?
Requena A Cruz M Pellicer A
Hum Reprod. 2019 Jul 8;34(7):1383-1385. doi: 10.1093/humrep/dez093. No abstract available.

Small-sized follicles could contribute to high-order multiple pregnancies: outcomes of 6552 intrauterine insemination cycles.
Giles J Cruz M González-Ravina C Caligara C Martínez JC Vergara V Requena A
Reprod Biomed Online, 37(5):549-554, 2018.

Small-sized follicles could contribute to high-order multiple pregnancies: outcomes of 6552 intrauterine insemination cycles.
Giles J Cruz M González-Ravina C Caligara C Prados N Martínez JC Vergara V Requena A
Reprod Biomed Online, 37(5):549-554, 2018.

Hysteroscopic septum resection and reproductive medicine: A SWOT analysis.
Spanish Infertility SWOT Group (SISG) Checa MA Bellver J Bosch E Espinós JJ Fabregues F Fontes J García-Velasco JA Requena A
Reprod Biomed Online, 37(6):709-715, 2018.

Type of gonadotropin used during controlled ovarian stimulation induces differential gene expression in human cumulus cells: A randomized study.
Cruz M Requena A Agudo Garcillán D García-Velasco JA
Eur J Obstet Gynecol Reprod Biol. 2017 Jun 8;215:124-133. doi: 10.1016/j.ejogrb.2017.06.014. [Epub ahead of print]

Type of gonadotropin used during controlled ovarian stimulation induces differential gene expression in human cumulus cells: A randomized study.
Cruz M Requena A Agudo Garcillán D García-Velasco JA
Eur J Obstet Gynecol Reprod Biol. 2017 Jun 8;215:124-133. doi: 10.1016/j.ejogrb.2017.06.014. [Epub ahead of print]

Economic impact of ovarian stimulation with corifollitropin alfa versus conventional daily gonadotropins in oocyte donors: a randomized study.
Cruz M Alamá P Muñoz M Collado D Blanes C Solbes E Requena A
Reprod Biomed Online. 2017 Mar 14. pii: S1472-6483(17)30096-2. doi: 10.1016/j.rbmo.2017.03.003. [Epub ahead of print]

Adenomyosis in infertile women: prevalence and the role of 3D ultrasound as a marker of severity of the disease.
Puente J Fabris A Patel J Patel A Cerrillo M Requena A García-Velasco JA
Reprod Biol Endocrinol 2016; 14: 60

Type of gonadotropin during controlled ovarian stimulation affects the endocrine profile in follicular fluid and apoptosis rate in cumulus cells.
Requena A Cruz M Agudo Garcillán D Pacheco A García-Velasco JA
Eur J Obstet Gynecol Reprod Biol. 2016; 197:142-146

Assisted reproductive techniques after fertility-sparing treatments in gynaecological cancers
Zapardiel I Cruz M Diestro MD Requena A García-Velasco JA
Hum Reprod Update, 22, 2016.

Adenomyosis in infertile women: prevalence and the role of 3D ultrasound as a marker of severity of the disease
Puente J Fabris A Patel J Patel A Cerrillo M Requena A García-Velasco JA
Reprod Biol Endocrinol, 14(1):60, 2016

Type of gonadotropin during controlled ovarian stimulation affects the endocrine profile in follicular fluid and apoptosis rate in cumulus cells
Requena A Cruz M Agudo Garcillán D Pacheco A García-Velasco JA
Eur J Obstet Gynecol Reprod Biol, 197:142-6, 2016.

Assisted reproductive techniques after fertility-sparing treatments in gynaecological cancers.
Zapardiel I Cruz M Diestro MD Requena A García-Velasco JA
Hum Reprod Update. 2016.

Ongoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels.
Requena A Cruz M Pacheco A García-Velasco JA
Fertil Steril 2015; 104:879-883.

Monozygotic twinning after assisted reproductive technologies: a case report of asymmetric development and incidence during 19 years in an international group of in vitro fertilization clinics.
Tocino A Blasco V Vargas MJ Requena A Pellicer A Fernández-Sánchez M
Fertil Steril, 103 (5): 1185-1189, 2015

Ongoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels
Requena A Cruz M Pacheco A García-Velasco JA
Fertil Steril, 104:879-883, 2015.

High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study.
Requena A Cruz M Bosch E Meseguer M García-Velasco JA
Reprod Biol Endocrinol 2014; 26:69

Endocrine profile following stimulation with recombinant follicle-stimulating hormone and luteinizing hormone versus highly purified human menopausal gonadotropin.
Requena A Cruz M Ruiz FJ García-Velasco JA
Reprod Biol Endocrinol 2014; 12:69

Embryo aneuploidy screening with CGH arrays in the absence of implantation.
García-Herrero S García-Herrero S Rodrigo L Mateu E Peinado V Milán M Campos-Galindo I Vera M Mercader A Bronet F Requena A Simón C Rubio C
Médecine de la Reproduction, Gynécologie Endocrinologie, 16:112-119, 2014.

Maternal KIR haplotype influence life birth rate after embryo transfer in vitro fertilization (IVF) cycles.
Alecsandru D Garrido N Vicario J Barrio A Aparicio P Requena A García-Velasco JA
Hum Reprod, 29(12):2637-43, 2014.

Maternal KIR haplotype influences live birth rate after double embryo transfer in IVF cycles in patients with recurrent miscarriages and implantation failure.
Alecsandru D Garrido N Vicario J Barrio A Aparicio P, Requena A García-Velasco JA
Hum Reprod. 29:2637-43, 2014.

Endocrine profile following stimulation with recombinant follicle stimulating hormone and luteinizing hormone versus highly purified human menopausal gonadotropin.
Requena A Cruz M Ruiz F García-Velasco JA
Reprod Biol Endocrinol. 29;12:10, 2014.

Natural lh surge vs hCG triggered vs hormone replace treatment (HRT): do pregnancy rates differ?
Cerrillo M Guillen A Zapata A Herrero I Requena A García-Velasco JA
Fertil Steril, 100(3):S95-96, 2013.

Evaluation of the degree of satisfaction in oocyte donors using sustained-release FSH corifollitropin ?.
Requena A Cruz M Collado D Izquierdo A Ballesteros A Muñoz M García-Velasco JA
Reproductive BioMedicine Online, 26(3): 253-259, 2013

Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: a retrospective cohort study.
Meseguer M Rubio I Cruz M Basile N Marcos J Requena A
Fertil Steril, 98(6):1481-9, 2012.

Cycle scheduling with oral contraceptive pills in the GnRH antagonist protocol vs the long protocol: a randomized, controlled trial.
García-Velasco JA Bermejo A Ruiz F Martínez-Salazar J Requena A Pellicer A
Fertil Steril, 96:590-3, 2011.

The impact of in-vitro maturation of oocytes on aneuploidy rate.
Requena A Bronet F Guillén A Agudo Garcillán D Bou C García-Velasco JA
Reprod Biomed Online. 18:777-83, 2009.

Letrozole administration during the luteal phase after ovarian stimulation impacts corpus luteum function: a randomized, placebo-controlled trial.
García-Velasco JA Quea G Piró M Mayoral M Ruiz M Toribio M Requena A
Fertil Steril. 92:222-5, 2009.

GnRH analogue for the prevention of ovarian hyperstimulation syndrome: a pilot study.
Giles J Requena A García-Velasco JA Pacheco A Pellicer J Pellicer A
Fertil Steril. 91(4 Suppl):1366-9, 2009.

Endocrine modifications associated with final oocyte maturation with gonadotropin-releasing hormone agonists vs. human chorionic gonadotropin in women undergoing intrauterine insemination
Díaz I Guillén A Pacheco A Requena A Requena A
J Reprod Med. 53:33-9, 2008.

Estradiol supplementation during the luteal phase of IVF-ICSI patients: a randomized, controlled trial.
Serna J Cholquevilque JL Cela V Martínez-Salazar J Requena A García-Velasco JA
Fertil Steril. 90:2190-5, 2008.

Artículo de revisión "Diagnóstico por imagen”
Puente J Grañeras A Requena A
Cuadernos de Medicina Reproductiva, 13( 2) : 37-51, 2007.

The aromatase inhibitor letrozole increases the concentration of intraovarian androgens and improves in vitro fertilization outcome in low responder patients: a pilot study.
García-Velasco JA Moreno L Pacheco A Guillén A Duque L Requena A Pellicer A
Fertil Steril. 84:82-7, 2005.

Extended coasting duration exerts a negative impact on IVF cycle outcome due to premature luteinization.
Moreno L Diaz I Pacheco A Zúñiga A Requena A García-Velasco JA
Reprod Biomed Online. 9:500-4, 2004.

Recombinant vs. urinary follicle-stimulating hormone in couples undergoing intrauterine insemination. A randomized study.
Isaza V Requena A García-Velasco JA Remohí J Pellicer A Simón C
J Reprod Med. 48:112-8, 2003.

Transabdominal ultrasound-guided embryo transfer does not increase pregnancy rates in oocyte recipients.
García-Velasco JA Isaza V Martínez-Salazar J Landazábal A Requena A Remohí J Simón C
Fertil Steril. 78:855-9, 2002.

High doses of gonadotrophins combined with stop versus non-stop protocol of GnRH analogue administration in low responder IVF patients: a prospective, randomized, controlled trial.
García-Velasco JA Isaza V Requena A Martínez-Salazar FJ Landazábal A Remohí J Pellicer A Simón C
Hum Reprod 15:2292-6, 2000

Maternal serum creatine kinase: a possible predictor of tubal pregnancy?
García-Velasco JA Requena A Santisteban J
Am J Obstet Gynecol. 175:238-40, 1996.

Cruz M Alecsandru D Garcia Velasco J Requena A Use of granulocyte colony-stimulating factor during an assisted reproductive treatment does not increase the risk of birth defects. Presented at the 34rd annual meeting of the European Society of Human Reproduction and Embryology, Barcelona, Spain, July 1-4,2018

Calonge M Garrido N Cobo A Gonzalez-Valdes F Morbeck D Requena A Troncoso C Quantifying the parameters affecting the success of egg donor program: A predictive model and optimization tool. Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology, Geneva,Switerland, July 2-5 ,2017

González-Ravina C Cruz M Rubio C Fernández-Sánchez M Oquiñena E Ferrando R Requena A Polymorphic chromosome variants, human inversions, and their functional consequences in male infertility. Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology, Geneva,Switerland, July 2-5 ,2017

Rubio Lluesa C Cruz M González-Ravina C Fernández-Sánchez M Oquiñena E Requena A Polymorphism on chromosome 21 does not affect ovarian reserve but clinical outcomes after in vitro fertilization treatments. Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology, Geneva,Switerland, July 2-5 ,2017

Sánchez M Pacheco A Cruz M Requena A Assessment of sperm ploidy status by flow cytommetry correlates to embryo quality. Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology, Geneva,Switerland, July 2-5 ,2017

Vergara Bravo V Cruz M Goyri E Requena A Pituitary suppression protocol does affect clinical outcomes in egg donation cycles. Presented at the 33rd annual meeting of the European Society of Human Reproduction and Embryology, Geneva,Switerland, July 2-5 ,2017

Antonio Requena, M.D., Ph.D.

Biography

Education and Training

Publications

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