Antonio Requena, M.D., Ph.D.

Chief Medical Officer of IVIRMA Global

IVI Madrid

Antonio Requena, M.D., Ph.D.

Biography

Dr. Antonio Requena, MD, is Assistant Professor at Rey Juan Carlos University in the Department of Obstetrics and Gynecology; Director Master’s Degree in Biology and Technology Applied to Assisted Human Reproduction IVI Madrid-European University of Madrid; Former Executive Manager of IVI Congress; IVI Madrid Director and Chief Medical Officer of IVIRMA Global. He graduated from the Complutense University of Madrid in Medicine and he completed his training in Gynecology and Obstetrics at the Autonoma University in Madrid.

He went on to pursue a pre-doctoral training in invitro oocyte maturation at John Eppig’s laboratory (Bar Harbour, Maine, USA) and finally he achieved his PhD in Medicine from Rey Juan Carlos University in Madrid. Dr. Requena completed his training by studying several masters: Management Development at ESADE Business School, Management Program in Health Institutions at IESE Business School and Innovation and Leadership in Fertility in IE Business School.

He has participated as a tutor in several projects financed by public entities, such as “Influence of glucose metabolism during oocyte maturation in cellular apoptosis. Clinical application in the diabeticpatient” at Autonoma University in Madrid.

He is active in the Spanish Society of Fertility (SEF) and also attends the European Society of Human Reproduction and Embryology (ESHRE).
Dr. Requena has been invited to speak nationally and internationally and has authored and contributed in over 40 peer reviewed publications, published chapters and abstracts. He also serves as Ad Hoc Reviewer for the Reproductive Biomedicine Online, Human Reproduction, Fertility and
Sterility, and as the editor for a textbook on Reproductive Medicine. His research interests include Endocrinology, Ovarian Stimulations, and genetics in Reproductive Medicine.


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Education and Training

Graduated in Medicine Complutense University (Madrid) 1989
Pre-doctoral training in in-vitro oocyte maturation John Eppig’s laboratory (Bar Harbour,Maine, USA) 1998
Program of Management Development (ESADE Business School) 2009
PhD in Medicine Rey Juan Carlos University (Madrid) 2014
Advanced Management Program in Health Institutions (IESE Business School) 2015
Innovation and Leadership. (IE Business School) 2016

Publications


  • Adenomyosis in infertile women: prevalence and the role of 3D ultrasound as a marker of severity of the disease.
    Puente JM, Fabris A, Patel J, Patel A, Cerrillo M, Requena A, Garcia-Velasco JA. Reprod Biol Endocrinol 2016; 14: 60

  • Assisted reproductive techniques after fertility-sparing treatments in gynecological cancers.
    Zapardiel I, Cruz M, Diestro MD, Requena M, Garcia-Velasco JA. Hum Reprod Update 2016;22(3)

  • Type of gonadotropin during controlled ovarian stimulation affects the endocrine profile in follicular fluid and apoptosis rate in cumulus cells.
    Requena A, Cruz M, Agudo D, Pacheco A, Garcia-Velasco JA. Eur J Obstet Gynecol Reprod Biol. 2016; 197:142-146

  • Ongoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels.
    Requena A, Cruz M, Pacheco A, García-Velasco JA.
    Fertil Steril 2015; 104:879-883.

  • Monozygotic twinning after assisted reproductive technologies: a case report of asymmetric development and incidence during 19 years in an international group of in vitro fertilization
    clinics.
    Tocino A, Blasco V, Prados N, Vargas MJ, Requena A, Pellicer A, Fernández-Sánchez M.
    Fertil Steril 2015; 103:1185-1189

  • Maternal KIR haplotype influences live birth rate after double embryo transfer in IVF cycles in patients with recurrent miscarriages and implantation failure.
    Alecsandru D, Garrido N, Vicario JL, Barrio A, Aparicio P, Requena A, García-Velasco JA.
    Hum Reprod 2014; 29:2637- 2643

  • High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study.
    Requena A, Cruz M, Bosch E, Meseguer M, García-Velasco JA.
    Reprod Biol Endocrinol 2014; 26:69

  • Endocrine profile following stimulation with recombinant follicle-stimulating hormone and luteinizing hormone versus highly purified human menopausal gonadotropin.
    Requena A, Cruz M, Ruiz FJ, García-Velasco JA.
    Reprod Biol Endocrinol 2014; 12:69


  • Evaluation of the degree of satisfaction in oocyte donors using sustained-release corifollitropin alfa.
    Requena A, Cruz M, Collado D, Izquierdo A, Ballesteros A, Muñoz M, García-Velasco JA.
    Reprod Biomed Online 2013; 26:253-259.

  • Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: a retrospective cohort study.
    Meseguer M, Rubio I, Cruz M, Basile, Marcos L, Requena A.
    Fertil Steril 2012; 98:1481-1489.

  • Efficacy and safety of human chorionic gonadotropin for follicular phase stimulation in assisted reproduction: a systematic review and meta-analysis.
    Checa MA, Espinós JJ, Requena A.
    Fertil Steril 2012; 97:1343-1350

  • Cycle scheduling with oral contraceptive pills in the GnRH antagonist protocol vs. the long protocol: a randomized, controlled trial.
    García-Velasco JA, Bermejo A, Ruiz F, Martínez-Salazar J, Requena A, Pellicer A.
    Fertil Steril 2011; 96:590-593.

  • Could the addition of hp-hMG and GnRH antagonists modulate the response in IVF-ICSI cycles?
    Requena A, Landeras JL, Martínez-Navarro L, Calatayud C, Sánchez F, Maldonado V, Muñoz M, Fernández M, González A, López S, López R, Pacheco A, Calderón G, Martínez V.
    Hum Fertil (Camb) 2010; 13:41-49

  • The impact of in vitro maturation of oocytes on aneuploidy rate.
    Requena A, Bronet F, Guillén A, Agudo D, Bou C, García-Velasco JA. Reprod Biomed Online 2009; 18:777-783.

  • Letrozole administration during the luteal phase after ovarian stimulation impacts corpus luteum function: a randomized, placebo controlled trial.
    García-Velasco JA, Quea G, Piró M, Mayoral M, Ruiz M, Toribio M, Requena A.
    Fertil Steril 2009; 92:222-225

  • GnRH analogue for the prevention of ovarian hyperstimulation syndrome: a pilot study.
    Giles J, Requena A, García-Velasco JA, Pacheco A, Pellicer J, Pellicer A. Fertil Steril 2009; 91:1366-1369.

  • Reproductive Endocrinology Interest Group of Spanish Society of Fertility. Use of letrozole in assisted reproduction: a systematic review and meta-analysis.
    Requena A, Herrero J, Landeras J, Navarro E, Neyro JL, Salvador C, Tur R, Callejo J, Checa MA, Farrá M, Espinós JJ, Fábregues F, Graña-Barcia M; Hum Reprod Update 2008; 14:571-582.

  • Endocrine modifications associated with final oocyte maturation with gonadotropin-releasing hormone agonists vs. human chorionic gonadotropin in women undergoing intrauterine insemination.
    Díaz I, Guillén A, Pacheco A, Requena A, García-Velasco JA.
    J Reprod Med 2008; 53:33-39

  • Estradiol supplementation during the luteal phase of IVF-ICSI patients: a randomized, controlled trial.
    Serna J, Cholquevilque JL, Cela V, Martínez-Salazar J, Requena A, García-Velasco JA.
    Fertil Steril 2008; 90:2190-2195.

  • Evaluation of the effectiveness and clinical security of Menopur in the ovarian stimulation in IVF-ICSI.
    Requena A, García-Velasco JA, Coroleu B, Alarcón M, Alberto-Bethencourt JC, Báez D, Balasch J, Bernabeu R, Brassesco M Caballero-Peregrín P, et al. Revista Iberoamericana de Fertilidad 2006; 23:245-255

  • The aromatase inhibitor letrozole increased the concentration of intraovarian androgens and improves in vitro fertilization outcome in low responder patients: a pilot study.
    García-Velasco JA, Moreno L, Pacheco A, Guillén A, Duque L, Requena A, Pellicer A.
    Fertil Steril 2005; 84:82-87

  • Insulin-sensitizing agents: use in pregnancy and as therapy in polycystic ovary syndrome.
    Checa MA, Requena A, Salvador C, Tur R, Callejo J, Espinós JJ, Fábregues F, Herrero J; Reproductive Endocrinology Interest Group of the Spanish Society Fertility.
    Hum Reprod Update 2005; 11:375-390.

  • Extended coasting duration exerts a negative impact on IVF cycle outcome due to premature luteinization.
    Moreno L, Díaz I, Pacheco A, Zúñiga A, Requena A, García-Velasco JA. Reprod Biomed Online 2004; 9:500-504.

  • Estudio comparativo, prospectivo y randomizado sobre el uso de hMG-up vs hMG-u en un programa de donación de ovocitos.
    Giles J, Requena A, Guillén A, García-Velasco JA.
    Revista Iberoamericana de Fertilidad 2004; 21:313-319.

  • Uso del antagonista de la GnRH en un protocolo de estimulación ovárica para FIV en pacientes con síndrome de ovario poliquístico.
    Requena A, Giles J, Martínez-Salazar J, García-Velasco JA.
    Revista Iberoamericana de Fertilidad 2003; 20:15-19.

  • Recombinant vs. Urinary follicle-stimulating hormone in couples undergoing intrauterine insemination. A randomized
    study.
    Isaza V, Requena A, García-Velasco JA, Remohí J, Pellicer A, Simón C.
    J Reprod Med 2003; 48:112-118

  • Transabdominal ultrasound-guided embryo transfer does not increase pregnancy rates in oocyte recipients.
    García-Velasco JA, Isaza V, Martínez-Salazar J, Landazábal A, Requena A, Remohí J, Simón C.
    Fertil Steril 2002; 78:534-539.

  • Endocrinological and ultrasonographic variations after immature oocyte retrieval in a natural cycle.
    Requena A, Neuspiller F, Cobo AC, Aragonés M, García-Velasco JA, Remohía J, Simón C, Pellicer A.
    Hum Reprod 2001; 16:1833-1837.

  • High doses of gonadotropins combined with stop versus non-stop protocol of GnRH analogue administration on low responder patients: a prospective, randomized, controlled
    trial.
    García-Velasco JA, Isaza V, Requena A, Martínez-Salazar J, Landazábal A, Remohí J, Pellicer A, Simón C.
    Hum Reprod 2000; 15:2292-2296.

  • Safety of long term oral estradiol administration in an oocyte donation program.
    Requena A, García-Velasco JA, Anarte C, Remohí J, Pellicer A, Simón C. Fertil Steril 2000; 74 (suppl 1):S158

  • The potential use of maturation in vitro of human oocytes in low responder patients.
    Requena A, Neuspiller F, Cobo AC, Aragonés M, Remohí J, Simón C, Pellicer A.
    J Assist Reprod Genet 2000; 17:239-244

  • Conditions that affect acquisition of developmental competence by mouse oocytes in vitro: FSH, insulin, glucose and ascorbic acid.
    Eppig JJ, Hosoe M, O-Brien MJ, Pendola FM, Requena A, Watanabe S.
    Mol Cell Endocrinol 2000; 163:109-116

  • Maturation in vitro of human oocytes from unstimulated cycles: selection of optimal day for ovum retrieval based on follicular size.
    Cobo AC, Requena A, Neuspiller F, Aragonés M, Mercader A, Navarro J, Simón C, Remohí J, Pellicer A.
    Hum Reprod 1999; 14:1864-1868

  • Implicaciones hormonales que comprometen la implantación.
    García-Velasco JA, Martínez-Salazar J, Requena A, Remohí J, Pellicer A, Simón C.
    Revista Iberoamericana de Fertilidad 1999; 16:327-334

  • Maternal serum creatine kinase: a posible predictor of tubal pregnancy.
    García-Velasco JA, Requena A, Santisteban J.
    J Obstet Gynaecol 1996; 175:238-240.

  • Acute leukemia during pregnancy: obstetric management and perinatal outcome of two cases.
    Requena A, García-Velasco JA, Pinilla J, González-González A.
    Eur J Obstet Gynecol Reprod Biol 1995; 63:139-141.

  • Pregnancy after myocardial infarction.
    García-Velasco JA, Requena A, González A.
    Int J Gynecol Obstet 1994; 47:291-292.


Book Chapters



  • Requena A. (2011). Estimulaçao ovariana em reproduçao assistida de alta complexidade: analogos antagonistas do GnRH. En: N.E. Busso/A. Pellicer (coord.), Induçao da ovulaçao (pp.184-194). Ed. Silvestre

  • Requena A. (2009). Inducción de la maduración final del ovocito con uso de diferentes dosis de gonadotropina coriónica humana: un ensayo clínico preliminar realizado con asignación aleatoria sobre pacientes con síndrome del ovario poliquístico tratadas mediante antagonistas de la hormona liberadora de gonadotropinas, hormona liberadora de gonadotropinas y hormona folículo estimulante recombinante. En: Update en Antagonistas de la GnRH en
    Reproducción Asistida (Síndrome del Ovario Poliquístico). Madrid

  • Requena A. (2009). Uso del antagonista de la GnRH en un protocolo de estimulación ovárica para FIV en pacientes con síndrome ovario poliquístico. En: Update en Antagonistas de la GnRH en Reproducción Asistida (Síndrome del Ovario Poliquístico). Madrid

  • Requena A. (2009). Estimulación ovárica mediante antagonistas de la GnRH para FIV en pacientes con baja respuesta a las gonadotropinas, síndrome del ovario poliquístico y riesgo de hiper-estimulación ovárica: un meta-análisis. En: Update en Antagonistas de la GnRH en Reproducción Asistida (Síndrome del Ovario Poliquístico). Madrid

  • Remohí J, Bellver J, Requena A, Pellicer A (2009). Guía de Protocolos en Reproducción Humana. En: Guía de Protocolos en Reproducción Humana. Madrid. Momento Médico Iberoamericana S.L

  • Requena A (2008). Uso de los inhibidores de la aromatasa en ginecología funcional. En: Actualidad y controversias en Ginecología (pp. 2-5). Madrid. Glosa S.L

  • Requena A, Giles J, Zúñiga A, Remohí J (2003). Donación de ovocitos. En: Temas actuales en medicina reproductiva y ginecología (pp. 313-323). México. Intersistemas S.A

  • Landazábal A, Villasante A, Scheffer B, Arbués J, Requena A, Giles J, Pellicer A, Remohí J, García- Velasco JA (2002). Endometriosis y Técnicas de Reproducción Asistida. En: Reproducción Humana 2º Ed. (pp. 221-226). Madrid. MacGraw Hill-Interamericana.

  • Requena A, Martínez-Salazar J, Párraga M, Isaza V, Landazábal A, García-Velasco JA, Simón C, Pellicer a, Remohí J (2002). Inseminación Artificial. En: Reproducción Humana 2º Ed. (pp. 263- 272). Madrid. MacGraw Hill-Interamericana.

  • Requena A, Villasante A, Arbués J, Giles J, García-Velasco JA, Pellicer A, Remohí J (2002). Crecimiento y maduración del ovocito. En: Reproducción Humana 2º Ed. (pp. 385-391). Madrid. MacGraw Hill-Interamericana.

  • Simón C, Requena A (2001). Recombinantes vs. agonistas y antagonistas en Reproducción Asistida. En: Ginecología. Temas Actuales (pp. 99-114).
    12. Requena A, Martínez-Salazar J, Vidal C, Simón C, Pellicer A, Remohí J (2000). La estimulación ovárica en Reproducción Asistida. En: Manual Práctico de Reproducción Humana (pp. 129- 150). Madrid. MacGraw Hill-Interamericana.

  • Requena A, Martínez-Salazar J, García-Velasco JA, Remohí J (2000). Analogos antagonistas de GnRH en Reproduçao Assistida. En: N.E. Busso/A. Pellicer (coord.), Induçao da ovulaçao
    (pp.130-136). Ed. Silvestre

  • García-Velasco JA, Requena A, Herrero de Lucas F, Álvarez Charines E, González-González A (1997). Utilidad del Doppler en la exploración de la gestante diabética. En: Acta Ginecológica (vol. LIV, pp. 39-44).

  • Martínez-Salazar J, Requena A, Herrera M, González-González A (1996). Cáncer gástrico y gestación. En: Progresos de Obstetricia y Ginecología (vol.39, pp. 754-756).

  • Requena A, García-Velasco JA, Pallardó FLF, Martín-Vaquero P, Hawking F, Jáñez M, González- González A (1996). Diabetes F y FR: control obstétrico y resultados perinatales. En: Progresos de Obstetricia y Ginecología (vol.39, pp. 423-433).

  • Requena A, García-Velasco JA, Román A, González-González A (1996). Síndrome de McKusick- Kaufman. En: Progresos de Obstetricia y Ginecología (vol.39, pp. 68-71).


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