Danilo Cimadomo, Ph.D., M.Sc.

Biography

Danilo Cimadomo is the Science and Research Manager of the GENERA centres for reproductive medicine (Italy). He received his B.Sc. and M.Sc. degrees at the University of Pavia in “Medical…

Danilo Cimadomo is the Science and Research Manager of the GENERA centres for reproductive medicine (Italy).

He received his B.Sc. and M.Sc. degrees at the University of Pavia in “Medical Biotechnologies” and “Molecular Biology and Genetics”, and its Ph.D. at the University of Rome “Sapienza” in “Morphogenesis and Tissue Engineering”. After two internships at the University of Pavia and at the University of Cambridge, in 2012, he started working at GENERA where he contributed to the validation, implementation, quality control and monitoring of a blastocyst stage PGT program. In 2017, he became scientific coordinator the GENERA centres for reproductive medicine in Italy. In 2020, he became Science and Research Manager of GeneraLife IVF network in Europe.

His basic science research is mainly focused on the acquisition of oocyte competence during folliculogenesis, oocyte and embryo chromosomal competence, and embryo-endometrial crosstalk at implantation. His clinical science research is mainly focused on the strategies to improve oocyte and embryo selection. He authored over 100 publications in international peer-reviewed journals.

He is part of the Executive Committee of the Italian Society of embryology, reproduction, and research (SIERR) with the role of coordinator of the scientific board.

He is Basic Science officer and Coordinator Elect of the ESHRE special interest group in implantation and early pregnancy (SIGIEP).

He was part of the ESHRE working groups that updated the good practice recommendations for embryo biopsy in IVF and the good practice recommendations for the definition, diagnosis, and treatment of repeated implantation failure (RIF).

He serves as Reviewer for several journals in the field of reproductive medicine and embryology. He was Guest Editor of three special issues in the Journal of Assisted Reproduction and Genetics, in Cells, and in the Journal of Clinical Medicine. He is Associate Editor of Human Reproduction Update, and Section Editor in clinical embryology of Reproductive BioMedicine Online.

He is the coordinator, together with Professor Maurizio Zuccotti, of a Master course “Biology and Biotechnology of Reproduction: from Research to Clinics” at the University of Pavia.

Education and Training

B.Sc. - “Medical Biotechnologies”	University of Pavia, Italy (2009)
Erasmus Placement - Addenbrooke’s Hospital, Department of Obstetrics & Gynaecology	University of Cambridge (UK) (2011)
M.Sc. - “Molecular Biology and Genetics”	University of Pavia, Italy (2012)
Post-Grad course – “New Technologies in molecular medicine”	University of Padova, Italy (2013)
Ph.D. – “Morphogenesis and Tissue Engineering”	University of Rome “Sapienza” (2017)
National Scientific License as associate professor in Obstetrics and Gynaecology conferred	Ministry of University and Research (MUR) (2020-2031)
Coordinator – “Master course in Biology and Biotechnologies of Reproduction	Research to Clinic” (2021-ongoing)

Honors and recognition

Best Oral Communication at the SIFES-MR (Italian Society of Fertility and Sterility and Reproductive Medicine) National Congress	2014 and 2016
Grant “Avvio alla Ricerca” received from University of Rome “Sapienza”	2016 and 2017
Top 10% Reviewer of the journals Human Reproduction and Human Reproduction Open	2019
Member of the ESHRE working groups that updated the good practice recommendations for embryo biopsy in IVF	2019-2020
Basic Science officer and Coordinator Elect of the ESHRE special interest group in implantation and early pregnancy (SIGIEP)	2019-ongoing
Associate Editor of the journal Human Reproduction Update	2020-ongoing
Member of the ESHRE working groups that drafted the good practice recommendations for the definition, diagnosis, and treatment of repeated implantation failure (RIF)	2022-2023
Guest Editor in the Journal of Assisted Reproduction and Genetics	2022
Guest Editor in the journal Cells	2022-2023
Guest Editor in the Journal of Clinical Medicine	2023-ongoing
Section Editor for clinical embryology in the journal Reproductive BioMedicine Online	2023-ongoing

Publications

The first mitotic division: a perilous bridge connecting the zygote and the early embryo.
Coticchio G, Cimadomo D, Cermisoni GC, Rienzi L, Papaleo E, Ubaldi FM, Borini A, De Santis L

Hum Reprod. 2023 Apr 7:dead067. doi: 10.1093/humrep/dead067. Online ahead of print.. 2023 doi:

Clinical and laboratory key performance indicators in IVF: A consensus between the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR) and the Italian Society of Embryology, Reproduction and Research (SIERR).
Vaiarelli A, Zaca C, Spadoni V, Cimadomo D, Conforti A, Alviggi C, Palermo R, Bulletti C, De Santis L, Pisaturo V, Vigiliano V, Scaravelli G, Ubaldi FM, Borini A

J Assist Reprod Genet. 2023 Apr 24. doi: 10.1007/s10815-023-02792-1. Online ahead of print.. 2023 doi:

Humidified atmosphere in a time-lapse embryo culture system does not improve ongoing pregnancy rate: a retrospective propensity score model study derived from 496 first ICSI cycles.
Bartolacci A, Borini A, Cimadomo D, Fabozzi G, Maggiulli R, Lagalla C, Pignataro D, dell'Aquila M, Parodi F, Patria G, Zacà C, Ubaldi FM, Rienzi L, Coticchio G

J Assist Reprod Genet. 2023 May 3. doi: 10.1007/s10815-023-02818-8. Online ahead of print. . 2023 doi:

From a cycle-by-cycle to a multi-cycle treatment planning: the next relevant shift in perspective needed in ART?
Faustini F, Cimadomo D, Ubaldi FM, Rienzi L

Fertil Steril. 2023 May 8:S0015-0282(23)00372-2. doi: 10.1016/j.fertnstert.2023.05.001. Online ahead of print. . 2023 doi:

Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis.
Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, Poli M, Hynes J, Gemmell L, Vaiarelli A, Alviggi C, Ubaldi FM, Capalbo A

Hum Reprod Update. 2023 May 16:dmad010. doi: 10.1093/humupd/dmad010. Online ahead of print.. 2023 doi:

Low-quality evidence from a randomized controlled trial due to an inappropriate IVF setting to challenge Dual Stimulation strategy.
Ubaldi FM, Vaiarelli A, Cimadomo D, Cerrillo M, Rienzi L, Garcia-Velasco JA

Hum Reprod. 2023 Jun 5:dead108. doi: 10.1093/humrep/dead108. Online ahead of print.. 2023 doi:

ESHRE good practice recommendations on recurrent implantation failure.
ESHRE Working Group on Recurrent Implantation Failure, Cimadomo D, de Los Santos MJ, Griesinger G, Lainas G, Le Clef N, McLernon DJ, Montjean D, Toth B, Vermeulen N, Macklon N

Hum Reprod Open. 2023 Jun 15;2023(3):hoad023. doi: 10.1093/hropen/hoad023. eCollection 2023.. 2023 doi:

How should the best human embryo in vitro be? Current and future challenges for embryo selection.
Cimadomo D, Innocenti F, Taggi M, Saturno G, Campitiello MR, Guido M, Vaiarelli A, Ubaldi FM, Rienzi L

Minerva Obstet Gynecol. 2023 Jun 16. doi: 10.23736/S2724-606X.23.05296-X. Online ahead of print.. 2023 doi:

Cryostorage management of reproductive cells and tissues in ART: status, needs, opportunities, and potential new challenges
Canosa S, Maggiulli R, Cimadomo D, Innocenti F, Fabozzi G, Gennarelli G, Revelli A, Bongioanni F, Vaiarelli A, Ubaldi FM, Rienzi L, Palmer GA, Nijs M

Reproductive BioMedicine Online Available online 22 June 202 In press. 2023 doi:

DuoStim reduces time to pregnancy, minimizes treatment discontinuation, and is potentially cost-effective.
Garcia-Velasco JA, Cimadomo D, Cerrillo M, Vaiarelli A, Ubaldi FM

Hum Reprod. 2023 Jun 23:dead113. doi: 10.1093/humrep/dead113. Online ahead of print.. 2023 doi:

Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: implications for fertility.
Fiorentino G, Cimadomo D, Innocenti F, Soscia D, Vaiarelli A, Ubaldi FM, Gennarelli G, Garagna S, Rienzi L, Zuccotti M

Hum Reprod Update. 2023 Jan 5;29(1):1-23. doi: 10.1093/humupd/dmac031.. 2023 doi:

Maternal age affects pronuclear and chromatin dynamics, morula compaction and cell polarity, and blastulation of human embryos.
Ezoe K, Miki T, Akaike H, Shimazaki K, Takahashi T, Tanimura Y, Amagai A, Sawado A, Mogi M, Kaneko S, Ueno S, Coticchio G, Cimadomo D, Borini A, Rienzi L, Kato K

Hum Reprod. 2023 Jan 16:dead001. doi: 10.1093/humrep/dead001. Online ahead of print.. 2023 doi:

Diabetes and erectile dysfunction: The relationships with health literacy, treatment adherence, unrealistic optimism, and glycaemic control.
Defeudis G, Mazzilli R, Scandurra C, Di Tommaso AM, Cimadomo D, Strollo R, Faggiano A, Migliaccio S, Napoli N

Diabetes Metab Res Rev. 2023 Feb 23:e3629. doi: 10.1002/dmrr.3629. Online ahead of print.. 2023 doi:

Male factor infertility and assisted reproductive technologies: indications, minimum access criteria and outcomes.
Mazzilli R, Rucci C, Vaiarelli A, Cimadomo D, Ubaldi FM, Foresta C, Ferlin AJ

Endocrinol Invest. 2023 Jan 12. doi: 10.1007/s40618-022-02000-4. Online ahead of print.. 2023 doi:

Towards Automation in IVF: Pre-Clinical Validation of a Deep Learning-Based Embryo Grading System during PGT-A Cycles.
Cimadomo D, Chiappetta V, Innocenti F, Saturno G, Taggi M, Marconetto A, Casciani V, Albricci L, Maggiulli R, Coticchio G, Ahlström A, Berntsen J, Larman M, Borini A, Vaiarelli A, Ubaldi FM, Rienzi L

J Clin Med. 2023 Feb 23;12(5):1806. doi: 10.3390/jcm12051806.. 2023 doi:

The first mitotic division: a perilous bridge connecting the zygote and the early embryo.
Coticchio G, Cimadomo D, Cermisoni GC, Rienzi L, Papaleo E, Ubaldi FM, Borini A, De Santis L

Hum Reprod. 2023 Apr 7:dead067. doi: 10.1093/humrep/dead067. Online ahead of print.. 2023 doi:

Clinical and laboratory key performance indicators in IVF: A consensus between the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR) and the Italian Society of Embryology, Reproduction and Research (SIERR).
Vaiarelli A, Zacà C, Spadoni V, Cimadomo D, Conforti A, Alviggi C, Palermo R, Bulletti C, De Santis L, Pisaturo V, Vigiliano V, Scaravelli G, Ubaldi FM, Borini A

J Assist Reprod Genet. 2023 Apr 24. doi: 10.1007/s10815-023-02792-1. Online ahead of print.. 2023 doi:

Humidified atmosphere in a time-lapse embryo culture system does not improve ongoing pregnancy rate: a retrospective propensity score model study derived from 496 first ICSI cycles.
Bartolacci A, Borini A, Cimadomo D, Fabozzi G, Maggiulli R, Lagalla C, Pignataro D, dell'Aquila M, Parodi F, Patria G, Zacà C, Ubaldi FM, Rienzi L, Coticchio G

J Assist Reprod Genet. 2023 May 3. doi: 10.1007/s10815-023-02818-8. Online ahead of print. . 2023 doi:

From a cycle-by-cycle to a multi-cycle treatment planning: the next relevant shift in perspective needed in ART?
Faustini F, Cimadomo D, Ubaldi FM, Rienzi L

Fertil Steril. 2023 May 8:S0015-0282(23)00372-2. doi: 10.1016/j.fertnstert.2023.05.001. Online ahead of print. . 2023 doi:

Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis.
Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, Poli M, Hynes J, Gemmell L, Vaiarelli A, Alviggi C, Ubaldi FM, Capalbo A

Hum Reprod Update. 2023 May 16:dmad010. doi: 10.1093/humupd/dmad010. Online ahead of print.. 2023 doi:

Low-quality evidence from a randomized controlled trial due to an inappropriate IVF setting to challenge Dual Stimulation strategy.
Ubaldi FM, Vaiarelli A, Cimadomo D, Cerrillo M, Rienzi L, Garcia-Velasco JA

Hum Reprod. 2023 Jun 5:dead108. doi: 10.1093/humrep/dead108. Online ahead of print.. 2023 doi:

ESHRE good practice recommendations on recurrent implantation failure.
ESHRE Working Group on Recurrent Implantation Failure, Cimadomo D, de Los Santos MJ, Griesinger G, Lainas G, Le Clef N, McLernon DJ, Montjean D, Toth B, Vermeulen N, Macklon N

Hum Reprod Open. 2023 Jun 15;2023(3):hoad023. doi: 10.1093/hropen/hoad023. eCollection 2023.. 2023 doi:

How should the best human embryo in vitro be? Current and future challenges for embryo selection.
Cimadomo D, Innocenti F, Taggi M, Saturno G, Campitiello MR, Guido M, Vaiarelli A, Ubaldi FM, Rienzi L

Minerva Obstet Gynecol. 2023 Jun 16. doi: 10.23736/S2724-606X.23.05296-X. Online ahead of print.. 2023 doi:

Cryostorage management of reproductive cells and tissues in ART: status, needs, opportunities, and potential new challenges
Canosa S, Maggiulli R, Cimadomo D, Innocenti F, Fabozzi G, Gennarelli G, Revelli A, Bongioanni F, Vaiarelli A, Ubaldi FM, Rienzi L, Palmer GA, Nijs M

Reproductive BioMedicine Online Available online 22 June 202 In press. 2022 doi:

Endocrine-Disrupting Chemicals, Gut Microbiota, and Human (In)Fertility-It Is Time to Consider the Triad.
Fabozzi G, Rebuzzini P, Cimadomo D, Allori M, Franzago M, Stuppia L, Garagna S, Ubaldi FM, Zuccotti M, Rienzi L

Cells. 2022 Oct 22;11(21):3335. doi: 10.3390/cells11213335. . 2022 doi:

Multi- and Transgenerational Effects of Environmental Toxicants on Mammalian Reproduction.
Rebuzzini P, Fabozzi G, Cimadomo D, Ubaldi FM, Rienzi L, Zuccotti M, Garagna S

Cells. 2022 Oct 9;11(19):3163. doi: 10.3390/cells11193163.. 2022 doi:

The actual impact of SARS-CoV-2/COVID-19 pandemic on IVF activity: a survey across Italian ART centers.
Scaravelli G, Levi Setti PE, Gennarelli G, Mencaglia L, Ubaldi FM, De Luca R, Cimadomo D, Spoletini R, Vigiliano V, Sileri PP

J Assist Reprod Genet. 2022 Oct;39(10):2373-2380. doi: 10.1007/s10815-022-02600-2. Epub 2022 Aug 23.. 2022 doi:

The role of thyroid function in female and male infertility: a narrative review.
Mazzilli R, Medenica S, Di Tommaso AM, Fabozzi G, Zamponi V, Cimadomo D, Rienzi L, Ubaldi FM, Watanabe M, Faggiano A, La Vignera S, Defeudis G

J Endocrinol Invest. 2023 Jan;46(1):15-26. doi: 10.1007/s40618-022-01883-7. Epub 2022 Aug 9. . 2022 doi:

Human blastocyst spontaneous collapse is associated with worse morphological quality and higher degeneration and aneuploidy rates: a comprehensive analysis standardized through artificial intelligence.
Cimadomo D, Marconetto A, Trio S, Chiappetta V, Innocenti F, Albricci L, Erlich I, Ben-Meir A, Har-Vardi I, Kantor B, Sakov A, Coticchio G, Borini A, Ubaldi FM, Rienzi L

Hum Reprod. 2022 Sep 30;37(10):2291-2306. doi: 10.1093/humrep/deac175.. 2022 doi:

Avoid mixing apples and oranges: blastocysts diagnosed with uniform whole chromosome aneuploidies are reproductively incompetent and their transfer is harmful.
Capalbo A, Cimadomo D, Rienzi L, Garcìa-Velasco JA, Simòn C, Ubaldi FM

Hum Reprod. 2022 Aug 25;37(9):2213-2214. doi: 10.1093/humrep/deac149.. 2022 doi:

The Role of Antihyperglycemic Drugs and Diet on Erectile Function: Results from a Perspective Study on a Population with Prediabetes and Diabetes.
Defeudis G, Di Tommaso AM, Di Rosa C, Cimadomo D, Khazrai YM, Faggiano A, Cincione RI, Napoli N, Mazzilli R

J Clin Med. 2022 Jun 13;11(12):3382. doi: 10.3390/jcm11123382.. 2022 doi:

Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation.
Fabozzi G, Verdone G, Allori M, Cimadomo D, Tatone C, Stuppia L, Franzago M, Ubaldi N, Vaiarelli A, Ubaldi FM, Rienzi L, Gennarelli G

Nutrients. 2022 May 3;14(9):1918. doi: 10.3390/nu14091918.. 2022 doi:

The journey from oogenesis to implantation and beyond: a special issue of JARG by the Italian Society of Embryology, Reproduction and Research (SIERR).
Cimadomo D, Klinger FG, Scarica C, De Santis L

J Assist Reprod Genet. 2022 Apr;39(4):781-782. doi: 10.1007/s10815-022-02482-4. Epub 2022 Apr 25. 2022 doi:

How slow is too slow? A comprehensive portrait of Day 7 blastocysts and their clinical value standardized through artificial intelligence.
Cimadomo D, Soscia D, Casciani V, Innocenti F, Trio S, Chiappetta V, Albricci L, Maggiulli R, Erlich I, Ben-Meir A, Har-Vardi I, Vaiarelli A, Ubaldi FM, Rienzi L

Hum Reprod. 2022 May 30;37(6):1134-1147. doi: 10.1093/humrep/deac080. . 2022 doi:

Neither rationale nor scientific evidence exist to support that double stimulation is potentially unsafe.
Casarini L, Vaiarelli A, Cimadomo D, Santi D, Simoni M, Garcìa-Velasco JA, Alviggi C, La Marca A, Rienzi L, Ubaldi FM

Hum Reprod. 2022 Jul 30;37(8):1949-1950. doi: 10.1093/humrep/deac064.. 2022 doi:

Erectile dysfunction as a marker of endocrine and glycemic disorders.
Mazzilli R, Zamponi V, Olana S, Mikovic N, Cimadomo D, Defeudis G, Faggiano A

J Endocrinol Invest. 2022 Aug;45(8):1527-1534. doi: 10.1007/s40618-022-01788-5. Epub 2022 Apr 2.. 2022 doi:

Maternal effect factors that contribute to oocytes developmental competence: an update.
Innocenti F, Fiorentino G, Cimadomo D, Soscia D, Garagna S, Rienzi L, Ubaldi FM, Zuccotti M, SIERR

J Assist Reprod Genet. 2022 Apr;39(4):861-871. doi: 10.1007/s10815-022-02434-y. Epub 2022 Feb 15.. 2022 doi:

Second stimulation in the same ovarian cycle: an option to fully-personalize the treatment in poor prognosis patients undergoing PGT-A.
Vaiarelli A, Cimadomo D, Gennarelli G, Guido M, Alviggi C, Conforti A, Livi C, Revelli A, Colamaria S, Argento C, Giuliani M, De Angelis C, Matteo M, Canosa S, D'Alfonso A, Cimadomo V, Rienzi L, Ubaldi FM

J Assist Reprod Genet. 2022 Mar;39(3):663-673. doi: 10.1007/s10815-022-02409-z. Epub 2022 Feb 7.. 2022 doi:

The effect of extended cryo-storage following vitrification on embryo competence: a systematic review and meta-analysis.
Canosa S, Cimadomo D, Conforti A, Maggiulli R, Giancani A, Tallarita A, Golia F, Fabozzi G, Vaiarelli A, Gennarelli G, Revelli A, Bongioanni F, Alviggi C, Ubaldi FM, Rienzi L, SIERR

J Assist Reprod Genet. 2022 Apr;39(4):873-882. doi: 10.1007/s10815-022-02405-3. Epub 2022 Feb 4.. 2022 doi:

Lights and shadows of preimplantation genetic testing for aneuploidy: better focusing on the accurate report of nonmosaic aneuploidies.
Cimadomo D, Rienzi L, Ubaldi FM, Capalbo A

Fertil Steril. 2022 Feb;117(2):324-325. doi: 10.1016/j.fertnstert.2021.12.002. Epub 2021 Dec 26.. 2022 doi:

Clinical, obstetric and perinatal outcomes after vitrified-warmed euploid blastocyst transfer are independent of cryo-storage duration.
Cimadomo D, Fabozzi G, Dovere L, Maggiulli R, Albricci L, Innocenti F, Soscia D, Giancani A, Vaiarelli A, Guido M, Ubaldi FM, Rienzi L

Reprod Biomed Online. 2022 Feb;44(2):221-227. doi: 10.1016/j.rbmo.2021.09.027. Epub 2021 Oct 8.. 2022 doi:

Inter-centre reliability in embryo grading across several IVF clinics is limited: implications for embryo selection.
Cimadomo D, Sosa Fernandez L, Soscia D, Fabozzi G, Benini F, Cesana A, Dal Canto MB, Maggiulli R, Muzzì S, Scarica C, Rienzi L, De Santis L

Reprod Biomed Online. 2022 Jan;44(1):39-48. doi: 10.1016/j.rbmo.2021.09.022. Epub 2021 Oct 6. . 2022 doi:

Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial.
Capalbo A, Poli M, Rienzi L, Girardi L, Patassini C, Fabiani M, Cimadomo D, Benini F, Farcomeni A, Cuzzi J, Rubio C, Albani E, Sacchi L, Vaiarelli A, Figliuzzi M, Findikli N, Coban O, Boynukalin FK, Vogel I, Hoffmann E, Livi C, Levi-Setti PE, Ubaldi FM, Simón C

Am J Hum Genet. 2021 Dec 2;108(12):2238-2247. doi: 10.1016/j.ajhg.2021.11.002. Epub 2021 Nov 18.. 2021 doi:

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives.
Maggiulli R, Vaiarelli A, Cimadomo D, Giancani A, Tacconi L, Fabozzi G, Ubaldi FM, Rienzi L

J Vis Exp. 2021 Sep 16;(175). doi: 10.3791/61963.. 2021 doi:

Measuring success in IVF is a complex multidisciplinary task: time for a consensus?
Rienzi L, Cimadomo D, Vaiarelli A, Gennarelli G, Holte J, Livi C, Aura Masip M, Uher P, Fabozzi G, Ubaldi FM

Reprod Biomed Online. 2021 Nov;43(5):775-778. doi: 10.1016/j.rbmo.2021.08.012. Epub 2021 Aug 20. . 2021 doi:

Maternal body mass index associates with blastocyst euploidy and live birth rates: the tip of an iceberg?
Fabozzi G, Cimadomo D, Allori M, Vaiarelli A, Colamaria S, Argento C, Amendola MG, Innocenti F, Soscia D, Maggiulli R, Mazzilli R, Ubaldi N, Iussig B, Marchetti M, Rienzi L, Ubaldi FM

Reprod Biomed Online. 2021 Oct;43(4):645-654. doi: 10.1016/j.rbmo.2021.07.006. Epub 2021 Jul 22.. 2021 doi:

Severe male factor in in vitro fertilization: definition, prevalence, and treatment. An update.
Mazzilli R, Vaiarelli A, Dovere L, Cimadomo D, Ubaldi N, Ferrero S, Rienzi L, Lombardo F, Lenzi A, Tournaye H, Ubaldi FM

Asian J Androl. 2022 Mar-Apr;24(2):125-134. doi: 10.4103/aja.aja_53_21.. 2021 doi:

In vitro fertilization and andrology laboratory in 2030: expert visions.
Campbell A, Gardner DK, Meseguer M, Miller KA, Montag M, Palermo GD, Cheung S, Keating D, Xie P, Rosenwaks Z, Rienzi L, Innocenti F, Cimadomo D, Ubaldi FM, Sakkas D, Tucker MJ, Nel-Themaat L, Simon C

Fertil Steril. 2021 Jul;116(1):4-12. doi: 10.1016/j.fertnstert.2021.05.088.. 2021 doi:

In vitro fertilization and andrology laboratories in 2030.
Simon C, Campbell A, Gardner DK, Meseguer M, Miller KA, Montag M, Palermo GD, Cheung S, Keating D, Xie P, Rosenwaks Z, Rienzi L, Innocenti F, Cimadomo D, Ubaldi FM, Sakkas D, Tucker MJ, Nel-Themaat L

Fertil Steril. 2021 Jul;116(1):2-3. doi: 10.1016/j.fertnstert.2021.05.089.. 2021 doi:

Clinical validity and utility of preconception expanded carrier screening for the management of reproductive genetic risk in IVF and general population.
Capalbo A, Fabiani M, Caroselli S, Poli M, Girardi L, Patassini C, Favero F, Cimadomo D, Vaiarelli A, Simon C, Rienzi LF, Ubaldi FM

Hum Reprod. 2021 Jun 18;36(7):2050-2061. doi: 10.1093/humrep/deab087. 2021 doi:

Is a randomized controlled design sufficient for a trial to be valuable?
Ubaldi FM, Cimadomo D, Vaiarelli A, Rienzi L

Hum Reprod. 2021 Jul 19;36(8):2416-2417. doi: 10.1093/humrep/deab114.. 2021 doi:

Oocyte competence is independent of the ovulation trigger adopted: a large observational study in a setting that entails vitrified-warmed single euploid blastocyst transfer.
Cimadomo D, Vaiarelli A, Petriglia C, Fabozzi G, Ferrero S, Schimberni M, Argento C, Colamaria S, Giuliani M, Ubaldi N, Rienzi L, Ubaldi FM

J Assist Reprod Genet. 2021 Jun;38(6):1419-1427. doi: 10.1007/s10815-021-02124-1. Epub 2021 Mar 4.. 2021 doi:

Is it in our patients' blood? On a quest for predictors of blastocysts' aneuploidy rate.
Cimadomo D, Rienzi L, Ubaldi FM

Fertil Steril. 2021 Apr;115(4):888-889. doi: 10.1016/j.fertnstert.2021.02.013. Epub 2021 Feb 26.. 2021 doi:

Reply: 'Second stimulation in the same ovarian cycle', probably a terminology more appropriate than 'luteal phase stimulation' in the DuoStim protocol.
Vaiarelli A, Cimadomo D, Rienzi L, Ubaldi FM

Hum Reprod. 2021 May 17;36(6):1723-1724. doi: 10.1093/humrep/deab018.. 2021 doi:

Leave the past behind: women's reproductive history shows no association with blastocysts' euploidy and limited association with live birth rates after euploid embryo transfers.
Cimadomo D, Capalbo A, Dovere L, Tacconi L, Soscia D, Giancani A, Scepi E, Maggiulli R, Vaiarelli A, Rienzi L, Ubaldi FM

Hum Reprod. 2021 Mar 18;36(4):929-940. doi: 10.1093/humrep/deab014.. 2021 doi:

The Impact of Unbalanced Maternal Nutritional Intakes on Oocyte Mitochondrial Activity: Implications for Reproductive Function.
Fabozzi G, Iussig B, Cimadomo D, Vaiarelli A, Maggiulli R, Ubaldi N, Ubaldi FM, Rienzi L

Antioxidants (Basel). 2021 Jan 11;10(1):91. doi: 10.3390/antiox10010091.. 2021 doi:

When embryology meets genetics: the definition of developmentally incompetent preimplantation embryos (DIPE)-the consensus of two Italian scientific societies.
Cimadomo D, Capalbo A, Scarica C, Sosa Fernandez L, Rienzi L, Ciriminna R, Minasi MG, Novelli A, De Santis L, Zuccarello D

J Assist Reprod Genet. 2021 Feb;38(2):319-331. doi: 10.1007/s10815-020-02015-x. Epub 2020 Nov 24.. 2021 doi:

Metaphase-II oocyte competence is unlinked to the gonadotrophins used for ovarian stimulation: a matched case-control study in women of advanced maternal age.
Vaiarelli A, Cimadomo D, Scarafia C, Innocenti F, Amendola MG, Fabozzi G, Casarini L, Conforti A, Alviggi C, Gennarelli G, Benedetto C, Guido M, Borini A, Rienzi L, Ubaldi FM

J Assist Reprod Genet. 2023 Jan;40(1):169-177. doi: 10.1007/s10815-022-02684-w. Epub 2022 Dec 31.. 2023 doi:

Improved clinical utility of preimplantation genetic testing through the integration of ploidy and common pathogenic microdeletions analyses.
Caroselli S, Figliuzzi M, Picchetta L, Cogo F, Zambon P, Pergher I, Girardi L, Patassini C, Poli M, Bakalova D, Cimadomo D, Findikli N, Coban O, Serdarogullari M, Favero F, Bortolato S, Anastasi A, Capodanno F, Gallinelli A, Brancati F, Rienzi L, Ubaldi FM, Jimenez-Almazán J, Blesa-Jarque D, Miravet-Valenciano J, Rubio C, Simòn C, Capalbo A

Hum Reprod. 2023 Feb 22:dead033. doi: 10.1093/humrep/dead033. Online ahead of print.. 2023 doi:

Recombinant human luteinizing hormone co-treatment in ovarian stimulation for assisted reproductive technology in women of advanced reproductive age: a systematic review and meta-analysis of randomized controlled trials.
Conforti A, Esteves SC, Humaidan P, Longobardi S, D'Hooghe T, Orvieto R, Vaiarelli A, Cimadomo D, Rienzi L, Ubaldi FM, Zullo F, Alviggi C

Reprod Biol Endocrinol. 2021 Jun 21;19(1):91. doi: 10.1186/s12958-021-00759-4.. 2021 doi:

Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines.
Esteves SC, Conforti A, Sunkara SK, Carbone L, Picarelli S, Vaiarelli A, Cimadomo D, Rienzi L, Ubaldi FM, Zullo F, Andersen CY, Orvieto R, Humaidan P, Alviggi C

Front Endocrinol (Lausanne). 2021 Mar 19;12:587051. doi: 10.3389/fendo.2021.587051. eCollection 2021.. 2021 doi:

Blastulation rates of sibling oocytes in two IVF culture media: an evidence-based workflow to implement newly commercialized products.
Fabozzi G, Albricci L, Cimadomo D, Amendola MG, Sanges F, Maggiulli R, Ubaldi FM, Rienzi L

Reprod Biomed Online. 2021 Feb;42(2):311-322. doi: 10.1016/j.rbmo.2020.10.017. Epub 2020 Nov 4.. 2021 doi:

Endometriosis shows no impact on the euploid blastocyst rate per cohort of inseminated metaphase-II oocytes: A case-control study.
Vaiarelli A, Venturella R, Cimadomo D, Conforti A, Pedri S, Bitonti G, Iussig B, Gentile C, Alviggi E, Santopaolo S, Zullo F, Rienzi L, Ubaldi FM

Eur J Obstet Gynecol Reprod Biol. 2021 Jan;256:205-210. doi: 10.1016/j.ejogrb.2020.11.024. Epub 2020 Nov 11.. 2021 doi:

Perinatal and obstetric outcomes in singleton pregnancies following fresh versus cryopreserved blastocyst transfer: a meta-analysis.
Conforti A, Picarelli S, Carbone L, La Marca A, Venturella R, Vaiarelli A, Cimadomo D, Zullo F, Rienzi L, Ubaldi FM, Alviggi C

Reprod Biomed Online. 2021 Feb;42(2):401-412. doi: 10.1016/j.rbmo.2020.09.029. Epub 2020 Oct 5.. 2021 doi:

The euploid blastocysts obtained after luteal phase stimulation show the same clinical, obstetric and perinatal outcomes as follicular phase stimulation-derived ones: a multicenter study.
Vaiarelli A, Cimadomo D, Alviggi E, Sansone A, Trabucco E, Dusi L, Buffo L, Barnocchi N, Fiorini F, Colamaria S, Giuliani M, Argento C, Rienzi L, Ubaldi FM

Hum Reprod. 2020 Nov 1;35(11):2598-2608. doi: 10.1093/humrep/deaa203.. 2020 doi:

Which key performance indicators are most effective in evaluating and managing an in vitro fertilization laboratory?
Fabozzi G, Cimadomo D, Maggiulli R, Vaiarelli A, Ubaldi FM, Rienzi L

Fertil Steril. 2020 Jul;114(1):9-15. doi: 10.1016/j.fertnstert.2020.04.054. Epub 2020 Jun 9. . 2020 doi:

The dawn of the future: 30 years from the first biopsy of a human embryo. The detailed history of an ongoing revolution.
Cimadomo D, Rienzi L, Capalbo A, Rubio C, Innocenti F, García-Pascual CM, Ubaldi FM, Handyside A

Hum Reprod Update. 2020 Jun 18;26(4):453-473. doi: 10.1093/humupd/dmaa019.. 2020 doi:

COVID-19 and ART: the view of the Italian Society of Fertility and Sterility and Reproductive Medicine.
Vaiarelli A, Bulletti C, Cimadomo D, Borini A, Alviggi C, Ajossa S, Anserini P, Gennarelli G, Guido M, Levi-Setti PE, Palagiano A, Palermo R, Savasi V, Pellicer A, Rienzi L, Ubaldi FM

Reprod Biomed Online. 2020 Jun;40(6):755-759. doi: 10.1016/j.rbmo.2020.04.003. Epub 2020 Apr 8.. 2020 doi:

DuoStim - a reproducible strategy to obtain more oocytes and competent embryos in a short time-frame aimed at fertility preservation and IVF purposes. A systematic review.
Vaiarelli A, Cimadomo D, Petriglia C, Conforti A, Alviggi C, Ubaldi N, Ledda S, Ferrero S, Rienzi L, Ubaldi FM

Ups J Med Sci. 2020 May;125(2):121-130. doi: 10.1080/03009734.2020.1734694. Epub 2020 Apr 25.. 2020 doi:

Definition of a clinical strategy to enhance the efficacy, efficiency and safety of egg donation cycles with imported vitrified oocytes.
Rienzi L, Cimadomo D, Maggiulli R, Vaiarelli A, Dusi L, Buffo L, Amendola MG, Colamaria S, Giuliani M, Bruno G, Stoppa M, Ubaldi FM

Hum Reprod. 2020 Apr 28;35(4):785-795. doi: 10.1093/humrep/deaa009.. 2020 doi:

Incidence, Origin, and Predictive Model for the Detection and Clinical Management of Segmental Aneuploidies in Human Embryos.
Girardi L, Serdarogullari M, Patassini C, Poli M, Fabiani M, Caroselli S, Coban O, Findikli N, Boynukalin FK, Bahceci M, Chopra R, Canipari R, Cimadomo D, Rienzi L, Ubaldi F, Hoffmann E, Rubio C, Simon C, Capalbo A

Am J Hum Genet. 2020 Apr 2;106(4):525-534. doi: 10.1016/j.ajhg.2020.03.005. Epub 2020 Mar 26.. 2020 doi:

Validation of ART Calculator for Predicting the Number of Metaphase II Oocytes Required for Obtaining at Least One Euploid Blastocyst for Transfer in Couples Undergoing in vitro Fertilization/Intracytoplasmic Sperm Injection.
Esteves SC, Yarali H, Ubaldi FM, Carvalho JF, Bento FC, Vaiarelli A, Cimadomo D, Özbek İY, Polat M, Bozdag G, Rienzi L, Alviggi C

Front Endocrinol (Lausanne). 2020 Jan 24;10:917. doi: 10.3389/fendo.2019.00917. eCollection 2019.. 2020 doi:

The effect of ICSI-related procedural timings and operators on the outcome.
Maggiulli R, Cimadomo D, Fabozzi G, Papini L, Dovere L, Ubaldi FM, Rienzi L

Hum Reprod. 2020 Jan 1;35(1):32-43. doi: 10.1093/humrep/dez234.. 2020 doi:

Time of morulation and trophectoderm quality are predictors of a live birth after euploid blastocyst transfer: a multicenter study.
Rienzi L, Cimadomo D, Delgado A, Minasi MG, Fabozzi G, Gallego RD, Stoppa M, Bellver J, Giancani A, Esbert M, Capalbo A, Remohì J, Greco E, Ubaldi FM, Meseguer M

Fertil Steril. 2019 Dec;112(6):1080-1093.e1. doi: 10.1016/j.fertnstert.2019.07.1322.. 2019 doi:

Luteal phase after conventional stimulation in the same ovarian cycle might improve the management of poor responder patients fulfilling the Bologna criteria: a case series.
Vaiarelli A, Cimadomo D, Conforti A, Schimberni M, Giuliani M, D'Alessandro P, Colamaria S, Alviggi C, Rienzi L, Ubaldi FM

Fertil Steril. 2020 Jan;113(1):121-130. doi: 10.1016/j.fertnstert.2019.09.012. Epub 2019 Dec 16.. 2020 doi:

The POSEIDON Criteria and Its Measure of Success Through the Eyes of Clinicians and Embryologists.
Esteves SC, Alviggi C, Humaidan P, Fischer R, Andersen CY, Conforti A, Bühler K, Sunkara SK, Polyzos NP, Galliano D, Grynberg M, Yarali H, Özbek IY, Roque M, Vuong LN, Banker M, Rienzi L, Vaiarelli A, Cimadomo D, Ubaldi FM

Front Endocrinol (Lausanne). 2019 Nov 20;10:814. doi: 10.3389/fendo.2019.00814. eCollection 2019.. 2019 doi:

Similar miRNomic signatures characterize the follicular fluids collected after follicular and luteal phase stimulations in the same ovarian cycle.
Cimadomo D, Carmelo R, Parrotta EI, Scalise S, Santamaria G, Alviggi E, De Angelis MT, Sarro G, Vaiarelli A, Venturella R, Rienzi L, Zullo F, Ubaldi FM, Cuda G

.J Assist Reprod Genet. 2020 Jan;37(1):149-158. doi: 10.1007/s10815-019-01607-6. Epub 2019 Nov 7. . 2020 doi:

Chromosome errors in human eggs shape natural fertility over reproductive life span.
Gruhn JR, Zielinska AP, Shukla V, Blanshard R, Capalbo A, Cimadomo D, Nikiforov D, Chan AC, Newnham LJ, Vogel I, Scarica C, Krapchev M, Taylor D, Kristensen SG, Cheng J, Ernst E, Bjørn AB, Colmorn LB, Blayney M, Elder K, Liss J, Hartshorne G, Grøndahl ML, Rienzi L, Ubaldi F, McCoy R, Lukaszuk K, Andersen CY, Schuh M, Hoffmann ER

Science. 2019 Sep 27;365(6460):1466-1469. doi: 10.1126/science.aav7321.. 2019 doi:

Definition and validation of a custom protocol to detect miRNAs in the spent media after blastocyst culture: searching for biomarkers of implantation.
Cimadomo D, Rienzi L, Giancani A, Alviggi E, Dusi L, Canipari R, Noli L, Ilic D, Khalaf Y, Ubaldi FM, Capalbo A

Hum Reprod. 2019 Sep 29;34(9):1746-1761. doi: 10.1093/humrep/dez119.. 2019 doi:

Human Blastocyst Biopsy and Vitrification.
Maggiulli R, Giancani A, Cimadomo D, Ubaldi FM, Rienzi L

J Vis Exp. 2019 Jul 26;(149). doi: 10.3791/59625.. 2019 doi:

Management of Women With an Unexpected Low Ovarian Response to Gonadotropin.
Conforti A, Esteves SC, Cimadomo D, Vaiarelli A, Di Rella F, Ubaldi FM, Zullo F, De Placido G, Alviggi C

Front Endocrinol (Lausanne). 2019 Jun 27;10:387. doi: 10.3389/fendo.2019.00387. eCollection 2019.. 2019 doi:

Pharmacogenetics of FSH Action in the Female.
Conforti A, Vaiarelli A, Cimadomo D, Bagnulo F, Peluso S, Carbone L, Di Rella F, De Placido G, Ubaldi FM, Huhtaniemi I, Alviggi C

Front Endocrinol (Lausanne). 2019 Jun 26;10:398. doi: 10.3389/fendo.2019.00398. eCollection 2019.. 2019 doi:

Looking past the appearance: a comprehensive description of the clinical contribution of poor-quality blastocysts to increase live birth rates during cycles with aneuploidy testing.
Cimadomo D, Soscia D, Vaiarelli A, Maggiulli R, Capalbo A, Ubaldi FM, Rienzi L

Hum Reprod. 2019 Jul 8;34(7):1206-1214. doi: 10.1093/humrep/dez078.. 2019 doi:

Embryonic cell-free DNA versus trophectoderm biopsy for aneuploidy testing: concordance rate and clinical implications.
Rubio C, Rienzi L, Navarro-Sánchez L, Cimadomo D, García-Pascual CM, Albricci L, Soscia D, Valbuena D, Capalbo A, Ubaldi F, Simón C

Fertil Steril. 2019 Sep;112(3):510-519. doi: 10.1016/j.fertnstert.2019.04.038. Epub 2019 Jun 11.. 2019 doi:

The main will of the patients of a private Italian IVF clinic for their aneuploid/affected blastocysts would be donation to research: a currently forbidden choice.
Faustini F, Forte M, Capalbo A, Cimadomo D, Ubaldi FM, Rienzi L

J Assist Reprod Genet. 2019 Aug;36(8):1555-1560. doi: 10.1007/s10815-019-01465-2. Epub 2019 May 27.. 2019 doi:

State of the art and emerging drug therapies for female infertility.
Venturella R, Vaiarelli A, Cimadomo D, Pedri S, Lico D, Mazzilli R, Mocciaro R, Rienzi L, Di Carlo C, Ubaldi FM, Zullo F

Gynecol Endocrinol. 2019 Oct;35(10):835-841. doi: 10.1080/09513590.2019.1603289. Epub 2019 Apr 29.. 2019 doi:

Perspectives in Gamete and Embryo Cryopreservation.
Rienzi LF, Iussig B, Dovere L, Fabozzi G, Cimadomo D, Ubaldi FM

Semin Reprod Med. 2018 Sep;36(5):253-264. doi: 10.1055/s-0038-1677463. Epub 2019 Apr 4. . 2019 doi:

Double stimulation in the same ovarian cycle (DuoStim) is an intriguing strategy to improve oocyte yield and the number of competent embryos in a short timeframe.
Vaiarelli A, Cimadomo D, Argento C, Ubaldi N, Trabucco E, Drakopoulos P, Venturella R, Conforti A, Alviggi C, Rienzi L, Ubaldi FM

Minerva Ginecol. 2019 Oct;71(5):372-376. doi: 10.23736/S0026-4784.19.04390-9. Epub 2019 Mar 4.. 2019 doi:

Advanced Maternal Age in IVF: Still a Challenge? The Present and the Future of Its Treatment.
Ubaldi FM, Cimadomo D, Vaiarelli A, Fabozzi G, Venturella R, Maggiulli R, Mazzilli R, Ferrero S, Palagiano A, Rienzi L

Front Endocrinol (Lausanne). 2019 Feb 20;10:94. doi: 10.3389/fendo.2019.00094. eCollection 2019.. 2019 doi:

A brief history of oocyte cryopreservation: Arguments and facts.
Iussig B, Maggiulli R, Fabozzi G, Bertelle S, Vaiarelli A, Cimadomo D, Ubaldi FM, Rienzi L

Acta Obstet Gynecol Scand. 2019 May;98(5):550-558. doi: 10.1111/aogs.13569. Epub 2019 Mar 25.. 2019 doi:

An integrated investigation of oocyte developmental competence: expression of key genes in human cumulus cells, morphokinetics of early divisions, blastulation, and euploidy.
Scarica C, Cimadomo D, Dovere L, Giancani A, Stoppa M, Capalbo A, Ubaldi FM, Rienzi L, Canipari R

J Assist Reprod Genet. 2019 May;36(5):875-887. doi: 10.1007/s10815-019-01410-3. Epub 2019 Feb 1.. 2019 doi:

Diagnostic efficacy of blastocoel fluid and spent media as sources of DNA for preimplantation genetic testing in standard clinical conditions.
Capalbo A, Romanelli V, Patassini C, Poli M, Girardi L, Giancani A, Stoppa M, Cimadomo D, Ubaldi FM, Rienzi L

Fertil Steril. 2018 Oct;110(5):870-879.e5. doi: 10.1016/j.fertnstert.2018.05.031.. 2018 doi:

Associations of blastocyst features, trophectoderm biopsy and other laboratory practice with post-warming behavior and implantation.
Cimadomo D, Capalbo A, Levi-Setti PE, Soscia D, Orlando G, Albani E, Parini V, Stoppa M, Dovere L, Tacconi L, Ievoli E, Maggiulli R, Ubaldi FM, Rienzi L

Hum Reprod. 2018 Nov 1;33(11):1992-2001. doi: 10.1093/humrep/dey291.. 2018 doi:

Inconclusive chromosomal assessment after blastocyst biopsy: prevalence, causative factors and outcomes after re-biopsy and re-vitrification. A multicenter experience.
Cimadomo D, Rienzi L, Romanelli V, Alviggi E, Levi-Setti PE, Albani E, Dusi L, Papini L, Livi C, Benini F, Smeraldi A, Patassini C, Ubaldi FM, Capalbo A

Hum Reprod. 2018 Oct 1;33(10):1839-1846. doi: 10.1093/humrep/dey282.. 2018 doi:

Impact of Maternal Age on Oocyte and Embryo Competence.
Cimadomo D, Fabozzi G, Vaiarelli A, Ubaldi N, Ubaldi FM, Rienzi L

Front Endocrinol (Lausanne). 2018 Jun 29;9:327. doi: 10.3389/fendo.2018.00327. eCollection 2018.. 2018 doi:

Double Stimulation in the Same Ovarian Cycle (DuoStim) to Maximize the Number of Oocytes Retrieved From Poor Prognosis Patients: A Multicenter Experience and SWOT Analysis.
Vaiarelli A, Cimadomo D, Trabucco E, Vallefuoco R, Buffo L, Dusi L, Fiorini F, Barnocchi N, Bulletti FM, Rienzi L, Ubaldi FM

Front Endocrinol (Lausanne). 2018 Jun 14;9:317. doi: 10.3389/fendo.2018.00317. eCollection 2018.. 2018 doi:

Luteal phase anovulatory follicles result in the production of competent oocytes: intra-patient paired case-control study comparing follicular versus luteal phase stimulations in the same ovarian cycle.
Cimadomo D, Vaiarelli A, Colamaria S, Trabucco E, Alviggi C, Venturella R, Alviggi E, Carmelo R, Rienzi L, Ubaldi FM

Hum Reprod. 2018 Aug 1;33(8):1442-1448. doi: 10.1093/humrep/dey217.. 2018 doi:

Prevalence of XXY karyotypes in human blastocysts: multicentre data from 7549 trophectoderm biopsies obtained during preimplantation genetic testing cycles in IVF.
Mazzilli R, Cimadomo D, Rienzi L, Capalbo A, Levi Setti PE, Livi C, Vizziello D, Foresta C, Ferlin A, Ubaldi FM

Hum Reprod. 2018 Jul 1;33(7):1355-1363. doi: 10.1093/humrep/dey110.. 2018 doi:

Continuous embryo culture elicits higher blastulation but similar cumulative delivery rates than sequential: a large prospective study.
Cimadomo D, Scarica C, Maggiulli R, Orlando G, Soscia D, Albricci L, Romano S, Sanges F, Ubaldi FM, Rienzi L

J Assist Reprod Genet. 2018 Jul;35(7):1329-1338. doi: 10.1007/s10815-018-1195-4. Epub 2018 May 3.. 2018 doi:

What is new in the management of poor ovarian response in IVF?
Vaiarelli A, Cimadomo D, Ubaldi N, Rienzi L, Ubaldi FM

Curr Opin Obstet Gynecol. 2018 Jun;30(3):155-162. doi: 10.1097/GCO.0000000000000452.. 2018 doi:

Effect of the male factor on the clinical outcome of intracytoplasmic sperm injection combined with preimplantation aneuploidy testing: observational longitudinal cohort study of 1,219 consecutive cycles.
Mazzilli R, Cimadomo D, Vaiarelli A, Capalbo A, Dovere L, Alviggi E, Dusi L, Foresta C, Lombardo F, Lenzi A, Tournaye H, Alviggi C, Rienzi L, Ubaldi FM

Fertil Steril. 2017 Dec;108(6):961-972.e3. doi: 10.1016/j.fertnstert.2017.08.033. Epub 2017 Oct 3.. 2017 doi:

Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging.
Capalbo A, Hoffmann ER, Cimadomo D, Ubaldi FM, Rienzi L

Hum Reprod Update. 2017 Nov 1;23(6):706-722. doi: 10.1093/humupd/dmx026.. 2017 doi:

Abnormally fertilized oocytes can result in healthy live births: improved genetic technologies for preimplantation genetic testing can be used to rescue viable embryos in in vitro fertilization cycles.
Capalbo A, Treff N, Cimadomo D, Tao X, Ferrero S, Vaiarelli A, Colamaria S, Maggiulli R, Orlando G, Scarica C, Scott R, Ubaldi FM, Rienzi L

Fertil Steril. 2017 Dec;108(6):1007-1015.e3. doi: 10.1016/j.fertnstert.2017.08.004. Epub 2017 Sep 15.. 2017 doi:

Preimplantation genetic diagnosis for aneuploidy testing in women older than 44 years: a multicenter experience.
Ubaldi FM, Cimadomo D, Capalbo A, Vaiarelli A, Buffo L, Trabucco E, Ferrero S, Albani E, Rienzi L, Levi Setti PE

Fertil Steril. 2017 May;107(5):1173-1180. doi: 10.1016/j.fertnstert.2017.03.007. Epub 2017 Apr 19.. 2017 doi:

Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c.
Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D

Stem Cells Dev. 2016 Dec 15;25(24):1853-1862. doi: 10.1089/scd.2016.0212. Epub 2016 Oct 17.. 2016 doi:

Pre-implantation genetic testing in ART: who will benefit and what is the evidence?
Vaiarelli A, Cimadomo D, Capalbo A, Orlando G, Sapienza F, Colamaria S, Palagiano A, Bulletti C, Rienzi L, Ubaldi FM

.J Assist Reprod Genet. 2016 Oct;33(10):1273-1278. doi: 10.1007/s10815-016-0785-2. Epub 2016 Aug 5.. 2016 doi:

Implementing PGD/PGD-A in IVF clinics: considerations for the best laboratory approach and management.
Capalbo A, Romanelli V, Cimadomo D, Girardi L, Stoppa M, Dovere L, Dell'Edera D, Ubaldi FM, Rienzi L

J Assist Reprod Genet. 2016 Oct;33(10):1279-1286. doi: 10.1007/s10815-016-0768-3. Epub 2016 Jul 16. . 2016 doi:

Failure mode and effects analysis of witnessing protocols for ensuring traceability during PGD/PGS cycles.
Cimadomo D, Ubaldi FM, Capalbo A, Maggiulli R, Scarica C, Romano S, Poggiana C, Zuccarello D, Giancani A, Vaiarelli A, Rienzi L

Reprod Biomed Online. 2016 Sep;33(3):360-9. doi: 10.1016/j.rbmo.2016.06.002. Epub 2016 Jun 23.. 2016 doi:

Generation of meiomaps of genome-wide recombination and chromosome segregation in human oocytes.
Ottolini CS, Capalbo A, Newnham L, Cimadomo D, Natesan SA, Hoffmann ER, Ubaldi FM, Rienzi L, Handyside AH

Nat Protoc. 2016 Jul;11(7):1229-43. doi: 10.1038/nprot.2016.075. Epub 2016 Jun 16.. 2016 doi:

Follicular versus luteal phase ovarian stimulation during the same menstrual cycle (DuoStim) in a reduced ovarian reserve population results in a similar euploid blastocyst formation rate: new insight in ovarian reserve exploitation.
Ubaldi FM, Capalbo A, Vaiarelli A, Cimadomo D, Colamaria S, Alviggi C, Trabucco E, Venturella R, Vajta G, Rienzi L

Fertil Steril. 2016 Jun;105(6):1488-1495.e1. doi: 10.1016/j.fertnstert.2016.03.002. Epub 2016 Mar 25.. 2016 doi:

The Impact of Biopsy on Human Embryo Developmental Potential during Preimplantation Genetic Diagnosis.
Cimadomo D, Capalbo A, Ubaldi FM, Scarica C, Palagiano A, Canipari R, Rienzi L

Biomed Res Int. 2016;2016:7193075. doi: 10.1155/2016/7193075. Epub 2016 Jan 28.. 2016 doi:

Consistent and reproducible outcomes of blastocyst biopsy and aneuploidy screening across different biopsy practitioners: a multicentre study involving 2586 embryo biopsies.
Capalbo A, Ubaldi FM, Cimadomo D, Maggiulli R, Patassini C, Dusi L, Sanges F, Buffo L, Venturella R, Rienzi L

Hum Reprod. 2016 Jan;31(1):199-208. doi: 10.1093/humrep/dev294. Epub 2015 Dec 4.. 2016 doi:

MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells and can be explored for human embryo reproductive competence assessment.
Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L

Fertil Steril. 2016 Jan;105(1):225-35.e1-3. doi: 10.1016/j.fertnstert.2015.09.014. Epub 2015 Oct 9.. 2016 doi:

Reduction of multiple pregnancies in the advanced maternal age population after implementation of an elective single embryo transfer policy coupled with enhanced embryo selection: pre- and post-intervention study.
Ubaldi FM, Capalbo A, Colamaria S, Ferrero S, Maggiulli R, Vajta G, Sapienza F, Cimadomo D, Giuliani M, Gravotta E, Vaiarelli A, Rienzi L

Hum Reprod. 2015 Sep;30(9):2097-106. doi: 10.1093/humrep/dev159. Epub 2015 Jul 5.. 2015 doi:

Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates.
Ottolini CS, Newnham L, Capalbo A, Natesan SA, Joshi HA, Cimadomo D, Griffin DK, Sage K, Summers MC, Thornhill AR, Housworth E, Herbert AD, Rienzi L, Ubaldi FM, Handyside AH, Hoffmann ER

Nat Genet. 2015 Jul;47(7):727-735. doi: 10.1038/ng.3306. Epub 2015 May 18.. 2015 doi:

Comparison of array comparative genomic hybridization and quantitative real-time PCR-based aneuploidy screening of blastocyst biopsies.
Capalbo A, Treff NR, Cimadomo D, Tao X, Upham K, Ubaldi FM, Rienzi L, Scott RT Jr

Eur J Hum Genet. 2015 Jul;23(7):901-6. doi: 10.1038/ejhg.2014.222. Epub 2014 Oct 29.. 2015 doi:

Correlation between standard blastocyst morphology, euploidy and implantation: an observational study in two centers involving 956 screened blastocysts.
Capalbo A, Rienzi L, Cimadomo D, Maggiulli R, Elliott T, Wright G, Nagy ZP, Ubaldi FM

Hum Reprod. 2014 Jun;29(6):1173-81. doi: 10.1093/humrep/deu033. Epub 2014 Feb 26.. 2014 doi:

SARS-CoV-2 persistence at subzero temperatures.
Scarica C, Parmegiani L, Rienzi L, Anastasi A, Cimadomo D, Klinger FG, Licata E, Sosa Fernandez L, De Santis L

J Assist Reprod Genet. 2021 Apr;38(4):779-781. doi: 10.1007/s10815-021-02094-4. Epub 2021 Feb 5.. 2021 doi:

Assessment and management of the risk of SARS-CoV-2 infection in an IVF laboratory.
Maggiulli R, Giancani A, Fabozzi G, Dovere L, Tacconi L, Amendola MG, Cimadomo D, Ubaldi FM, Rienzi L

Reprod Biomed Online. 2020 Sep;41(3):385-394. doi: 10.1016/j.rbmo.2020.06.017. Epub 2020 Jun 27.. 2020 doi:

Corrigendum. Definition of a clinical strategy to enhance the efficacy, efficiency and safety of egg donation cycles with imported vitrified oocytes.
Rienzi L, Cimadomo D, Maggiulli R, Vaiarelli A, Dusi L, Buffo L, Amendola MG, Colamaria S, Giuliani M, Bruno G, Stoppa M, Ubaldi FM

Hum Reprod. 2020 Aug 1;35(8):1944. doi: 10.1093/humrep/deaa145.. 2020 doi:

Multicenter prospective study of concordance between embryonic cell-free DNA and trophectoderm biopsies from 1301 human blastocysts.
Rubio C, Navarro-Sánchez L, García-Pascual CM, Ocali O, Cimadomo D, Venier W, Barroso G, Kopcow L, Bahçeci M, Kulmann MIR, López L, De la Fuente E, Navarro R, Valbuena D, Sakkas D, Rienzi L, Simón C

Am J Obstet Gynecol. 2020 Nov;223(5):751.e1-751.e13. doi: 10.1016/j.ajog.2020.04.035. Epub 2020 May 26.. 2020 doi:

Biochemical pregnancy loss after frozen embryo transfer seems independent of embryo developmental stage and chromosomal status.
Vaiarelli A, Cimadomo D, Patrizio P, Venturella R, Orlando G, Soscia D, Giancani A, Capalbo A, Rienzi L, Ubaldi FM

Reprod Biomed Online. 2018 Sep;37(3):349-357. doi: 10.1016/j.rbmo.2018.05.019. Epub 2018 Jun 30.. 2018 doi:

IUI and uterine lavage of in vivo-produced blastocysts for PGT purposes: is it a technically and ethically reasonable perspective? Is it actually needed?
De Santis L, Cimadomo D, Capalbo A, Di Pietro C, Zuccarello D, Anastasi A, Licata E, Scarica C, Fernandez LS, Klinger FG, Italian Society of Embryology, Reproduction and Research (SIERR)

.J Assist Reprod Genet. 2020 Jul;37(7):1579-1582. doi: 10.1007/s10815-020-01813-7. Epub 2020 May 26.. 2020 doi:

The High Prevalence of Testicular Adrenal Rest Tumors in Adult Men With Congenital Adrenal Hyperplasia Is Correlated With ACTH Levels.
Mazzilli R, Stigliano A, Delfino M, Olana S, Zamponi V, Iorio C, Defeudis G, Cimadomo D, Toscano V, Mazzilli F

Front Endocrinol (Lausanne). 2019 Jun 4;10:335. doi: 10.3389/fendo.2019.00335. eCollection 2019.. 2019 doi:

ESHRE PGT Consortium and SIG Embryology good practice recommendations for polar body and embryo biopsy for PGT.
ESHRE PGT Consortium and SIG-Embryology Biopsy Working Group, Kokkali G, Coticchio G, Bronet F, Celebi C, Cimadomo D, Goossens V, Liss J, Nunes S, Sfontouris I, Vermeulen N, Zakharova E, De Rycke M

Hum Reprod Open. 2020 May 29;2020(3):hoaa020. doi: 10.1093/hropen/hoaa020. eCollection 2020.. 2020 doi:

Improved clinical utility of preimplantation genetic testing through the integration of ploidy and common pathogenic microdeletions analyses.
Caroselli S, Figliuzzi M, Picchetta L, Cogo F, Zambon P, Pergher I, Girardi L, Patassini C, Poli M, Bakalova D, Cimadomo D, Findikli N, Coban O, Serdarogullari M, Favero F, Bortolato S, Anastasi A, Capodanno F, Gallinelli A, Brancati F, Rienzi L, Ubaldi FM, Jimenez-Almazán J, Blesa-Jarque D, Miravet-Valenciano J, Rubio C, Simòn C, Capalbo A

Hum Reprod. 2023 Feb 22:dead033. doi: 10.1093/humrep/dead033. Online ahead of print.. 2023 doi:

Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: implications for fertility.
Fiorentino G, Cimadomo D, Innocenti F, Soscia D, Vaiarelli A, Ubaldi FM, Gennarelli G, Garagna S, Rienzi L, Zuccotti M

Hum Reprod Update. 2023 Jan 5;29(1):1-23. doi: 10.1093/humupd/dmac031.. 2023 doi:

Maternal age affects pronuclear and chromatin dynamics, morula compaction and cell polarity, and blastulation of human embryos.
Ezoe K, Miki T, Akaike H, Shimazaki K, Takahashi T, Tanimura Y, Amagai A, Sawado A, Mogi M, Kaneko S, Ueno S, Coticchio G, Cimadomo D, Borini A, Rienzi L, Kato K

Hum Reprod. 2023 Jan 16:dead001. doi: 10.1093/humrep/dead001. Online ahead of print.. 2023 doi:

Diabetes and erectile dysfunction: The relationships with health literacy, treatment adherence, unrealistic optimism, and glycaemic control.
Defeudis G, Mazzilli R, Scandurra C, Di Tommaso AM, Cimadomo D, Strollo R, Faggiano A, Migliaccio S, Napoli N

Diabetes Metab Res Rev. 2023 Feb 23:e3629. doi: 10.1002/dmrr.3629. Online ahead of print.. 2023 doi:

Male factor infertility and assisted reproductive technologies: indications, minimum access criteria and outcomes.
Mazzilli R, Rucci C, Vaiarelli A, Cimadomo D, Ubaldi FM, Foresta C, Ferlin AJ

Endocrinol Invest. 2023 Jan 12. doi: 10.1007/s40618-022-02000-4. Online ahead of print.. 2023 doi:

Towards Automation in IVF: Pre-Clinical Validation of a Deep Learning-Based Embryo Grading System during PGT-A Cycles.
Cimadomo D, Chiappetta V, Innocenti F, Saturno G, Taggi M, Marconetto A, Casciani V, Albricci L, Maggiulli R, Coticchio G, Ahlström A, Berntsen J, Larman M, Borini A, Vaiarelli A, Ubaldi FM, Rienzi L

J Clin Med. 2023 Feb 23;12(5):1806. doi: 10.3390/jcm12051806.. 2023 doi:

Avoid mixing apples and oranges: blastocysts diagnosed with uniform whole chromosome aneuploidies are reproductively incompetent and their transfer is harmful.
Capalbo A, Cimadomo D, Rienzi L, Garcìa-Velasco JA, Simòn C, Ubaldi FM

Hum Reprod. . 2022 doi: 10.1093/humrep/deac149

Neither rationale nor scientific evidence exist to support that double stimulation is potentially unsafe.
Casarini L, Vaiarelli A, Cimadomo D, Santi D, Simoni M, Garcìa-Velasco JA, Alviggi C, La Marca A, Rienzi L, Ubaldi FM

Hum Reprod. 2022 Apr 8:deac064. Online ahead of print. 2022 doi: 10.1093/humrep/deac064

Presentations

Rienzi L Cimadomo D Delgado A Minasi MG Fabozzi G Del Gallego R Stoppa M Bellver J Giancani A Esbert M Capalbo A Remohí J Greco E Ubaldi F Meseguer M O-006: Time of morulation and trophectoderm quality are associated with live birth after euploid blastocyst transfer: a multicenter study. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver,CO,USA, 23-26 June 2019

Fertility Researchers

OUR INVESTIGATORS

Biography

Education and Training

Honors and recognition

Publications

Presentations