Antonio Capalbo, Ph.D.

Biography

Antonio Capalbo Ph.D., M.Sc is Chief Scientific Officer for Juno Genetics. Dr. Capalbo received his Bachelor of Science degree in Biotechnology from University of Rome ‘La Sapienza’ and his Ph.D….

Antonio Capalbo Ph.D., M.Sc is Chief Scientific Officer for Juno Genetics.

Dr. Capalbo received his Bachelor of Science degree in Biotechnology from University of Rome ‘La Sapienza’ and his Ph.D. magna cum laude in Human Genetics at the Catholic University of Sacred Heart of Rome in 2011. He obtained a Master’s Degree in Epidemiology and Biostatistical data analysis at Catholic University of Sacred Heart of Rome in 2011.

From 2008 to 2012 Dr. Capalbo has been working as a clinical embryologist, pioneering embryo biopsy approaches and applications. Since then, his research has focused on preimplantation genetic testing and on the development of novel molecular biology techniques to improve pregnancy and take-home baby rates in ART. His basic research has been focused on the mechanisms of aneuploidies in oocytes and preimplantation human embryos. He received several grants for innovative studies on these subjects. From 2012-2022 he has been co-founder and director of the largest PGT program in Italy and Europe.

He is currently coordinator of the ESHRE SIG in Reproductive Genetics, member of the genomics-working group of the Italian society of human genetics, and Chief Scientific Officer (CSO) at Juno Genetics.

He has published more than 100 peer-reviewed papers and book chapters and is currently Associated Editor for Human Reproduction Journal and section editor of RBM Online Journal. Furthermore he is ad hoc reviewer for many Journals in the field of reproductive biology and genetics (New England Journal of Medicine, American Journal of Human Genetics, Human Reproduction Update, Fertility and Sterility, , Journal of Assisted Reproduction and Genetics, Journal of Medical Genetics, Scientific Reports, PNAS).

Education and Training

M.Sc (Biology)	Sapienza University of Rome (2006)
Residency (Medical genetics)	Catholic University of Sacred Heart of Rome (2010)
Certification ESHRE (Clinical Embryologist)	(2010)
MsC (Epidemiology and Biostatistical data analysis)	Catholic University of Sacred Heart of Rome (2011)
PhD (Morphogenesis and tissue Engineering)	Sapienza University of Rome (2021)
Habilitation for university professorship (Medical Genetics)	(2022)

Honors and recognition

Clinical Science Award for poster presentation, ESHRE Annual Meeting	2002
Grant as co-author Novo Nordisk Foundation, Young Investigator Award (Open competition)	2018
Recognition of the excellent contribution of top 10% reviewers for Human Reproduction Journal	2011, 2015, 2016, 2017, 2018
Winner as principal investigator of the Grant for Fertility Innovation, Merk-Serono	2015
Best oral presentation at the Italian Annual Meeting of Reproductive Medicine Societies	2014
Oral communication selected for basic science award at the ESHRE annual meeting, Munich	2014
Best oral presentation at the Italian Annual Meeting of Reproductive Medicine Societies	2013
Winner as principal investigator of the Grant for Fertility Innovation, Merk-Serono	2013
Oral communication selected for clinical science award at the ASRM annual meeting, Boston	2013
Oral communication selected for basic science award at the ESHRE annual meeting, Istanbul	2012

Publications

Improved clinical utility of preimplantation genetic testing through the integration of ploidy and common pathogenic microdeletions analyses.
Caroselli S, Figliuzzi M, Picchetta L, Cogo F, Zambon P, Pergher I, Girardi L, Patassini C, Poli M, Bakalova D, Cimadomo D, Findikli N, Coban O, Serdarogullari M, Favero F, Bortolato S, Anastasi A, Capodanno F, Gallinelli A, Brancati F, Rienzi L, Ubaldi FM, Jimenez-Almazán J, Blesa-Jarque D, Miravet-Valenciano J, Rubio C, Simòn C, Capalbo A

Hum Reprod. 2023 Feb 22:dead033. doi: 10.1093/humrep/dead033. Online ahead of print.. 2023 doi:

Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis.
Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, Poli M, Hynes J, Gemmell L, Vaiarelli A, Alviggi C, Ubaldi FM, Capalbo A

Hum Reprod Update. 2023 May 16:dmad010. doi: 10.1093/humupd/dmad010. Online ahead of print.. 2023 doi:

Better late than never: the clinical value of Day 7 blastocysts.
Fraire-Zamora JJ, Serdarogullari M, Sharma K, Ammar OF, Mincheva M, Macklon N, Pujol A, Capalbo A, Meseguer M, Liperis G

Hum Reprod. 2023 Jan 4:deac269. doi: 10.1093/humrep/deac269. Online ahead of print.. 2023 doi:

Healthy live birth following embryo transfer of a blastocyst of tetrapronuclear (4PN) origin: a case report.
Bredbacka P, Capalbo A, Kananen K, Picchetta L, Tomás C

Hum Reprod. 2023 Aug 1:dead151. doi: 10.1093/humrep/dead151. Online ahead of print.. 2023 doi:

Implementing preconception expanded carrier screening in a universal healthcare system: a model-based cost-effectiveness analysis.
Busnelli A, Ciani O, Caroselli S, Figliuzzi M, Poli M, Levi-Setti PE, Tarricone R, Capalbo A

Genet Med. 2023 Jul 21:100943. doi: 10.1016/j.gim.2023.100943. Online ahead of print.. 2023 doi:

The human periconceptional maternal-embryonic space in health and disease.
Moreno I, Capalbo A, Mas A, Garrido-Gomez T, Roson B, Poli M, Dimitriadis E, Santamaria X, Vilella F, Simon C

Physiol Rev. 2023 Feb 16. doi: 10.1152/physrev.00050.2021. Online ahead of print. . 2023 doi:

Avoid mixing apples and oranges: blastocysts diagnosed with uniform whole chromosome aneuploidies are reproductively incompetent and their transfer is harmful.
Capalbo A, Cimadomo D, Rienzi L, Garcìa-Velasco JA, Simòn C, Ubaldi FM

Hum Reprod. 2022 Aug 25;37(9):2213-2214. doi: 10.1093/humrep/deac149.. 2022 doi:

ESHRE survey results and good practice recommendations on managing chromosomal mosaicism.
ESHRE Working Group on Chromosomal Mosaicism, De Rycke M, Capalbo A, Coonen E, Coticchio G, Fiorentino F, Goossens V, Mcheik S, Rubio C, Sermon K, Sfontouris I, Spits C, Vermeesch JR, Vermeulen N, Wells D, Zambelli F, Kakourou G

Hum Reprod Open. 2022 Nov 7;2022(4):hoac044. doi: 10.1093/hropen/hoac044. eCollection 2022.. 2022 doi:

Considerations on the use of carrier screening testing in human reproduction: comparison between recommendations from the Italian Society of Human Genetics and other international societies.
Capalbo A, Gabbiato I, Caroselli S, Picchetta L, Cavalli P, Lonardo F, Bianca S, Giardina E, Zuccarello D

J Assist Reprod Genet. 2022 Nov 12. doi: 10.1007/s10815-022-02653-3. Online ahead of print.. 2022 doi:

Fertility counseling in women with hereditary cancer syndromes.
Somigliana E, Costantini MP, Filippi F, Terenziani M, Riccaboni A, Nicotra V, Rago R, Paffoni A, Mencaglia L, Magnolfi S, Zuccarello D, Rienzi L, Spinella F, Capalbo A, Scaravelli G, Testa S, MUTAGENS Special Interest Group on parenting and fertility

Crit Rev Oncol Hematol. 2022 Mar;171:103604. doi: 10.1016/j.critrevonc.2022.103604. Epub 2022 Jan 25.. 2022 doi:

Lights and shadows of preimplantation genetic testing for aneuploidy: better focusing on the accurate report of nonmosaic aneuploidies.
Cimadomo D, Rienzi L, Ubaldi FM, Capalbo A

Fertil Steril. 2022 Feb;117(2):324-325. doi: 10.1016/j.fertnstert.2021.12.002. Epub 2021 Dec 26.. 2022 doi:

On the reproductive capabilities of aneuploid human preimplantation embryos.
Capalbo A, Poli M, Jalas C, Forman EJ, Treff NR

Am J Hum Genet. 2022 Sep 1;109(9):1572-1581. doi: 10.1016/j.ajhg.2022.07.009.. 2022 doi:

Update on preimplantation genetic testing for aneuploidy and outcomes of embryos with mosaic results.
Dahdouh EM, Mourad AM, Balayla J, Sylvestre C, Brezina PR, Kutteh WH, Picchetta L, Capalbo A, Garcia-Velasco JA

Minerva Obstet Gynecol. 2022 Oct 18. doi: 10.23736/S2724-606X.22.05166-1. Online ahead of print.. 2022 doi:

Clinical validity and utility of preconception expanded carrier screening for the management of reproductive genetic risk in IVF and general population.
Capalbo A, Fabiani M, Caroselli S, Poli M, Girardi L, Patassini C, Favero F, Cimadomo D, Vaiarelli A, Simon C, Rienzi LF, Ubaldi FM

Hum Reprod. 2021 Jun 18;36(7):2050-2061. doi: 10.1093/humrep/deab087. 2021 doi:

Leave the past behind: women's reproductive history shows no association with blastocysts' euploidy and limited association with live birth rates after euploid embryo transfers.
Cimadomo D, Capalbo A, Dovere L, Tacconi L, Soscia D, Giancani A, Scepi E, Maggiulli R, Vaiarelli A, Rienzi L, Ubaldi FM

Hum Reprod. 2021 Mar 18;36(4):929-940. doi: 10.1093/humrep/deab014.. 2021 doi:

Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial.
Capalbo A, Poli M, Rienzi L, Girardi L, Patassini C, Fabiani M, Cimadomo D, Benini F, Farcomeni A, Cuzzi J, Rubio C, Albani E, Sacchi L, Vaiarelli A, Figliuzzi M, Findikli N, Coban O, Boynukalin FK, Vogel I, Hoffmann E, Livi C, Levi-Setti PE, Ubaldi FM, Simón C

Am J Hum Genet. 2021 Dec 2;108(12):2238-2247. doi: 10.1016/j.ajhg.2021.11.002. Epub 2021 Nov 18.. 2021 doi:

When embryology meets genetics: the definition of developmentally incompetent preimplantation embryos (DIPE)-the consensus of two Italian scientific societies.
Cimadomo D, Capalbo A, Scarica C, Sosa Fernandez L, Rienzi L, Ciriminna R, Minasi MG, Novelli A, De Santis L, Zuccarello D

J Assist Reprod Genet. 2021 Feb;38(2):319-331. doi: 10.1007/s10815-020-02015-x. Epub 2020 Nov 24.. 2021 doi:

Incidence, Origin, and Predictive Model for the Detection and Clinical Management of Segmental Aneuploidies in Human Embryos.
Girardi L, Serdarogullari M, Patassini C, Poli M, Fabiani M, Caroselli S, Coban O, Findikli N, Boynukalin FK, Bahceci M, Chopra R, Canipari R, Cimadomo D, Rienzi L, Ubaldi F, Hoffmann E, Rubio C, Simon C, Capalbo A

Am J Hum Genet. 2020 Apr 2;106(4):525-534. doi: 10.1016/j.ajhg.2020.03.005. Epub 2020 Mar 26.. 2020 doi:

IUI and uterine lavage of in vivo-produced blastocysts for PGT purposes: is it a technically and ethically reasonable perspective? Is it actually needed?
De Santis L, Cimadomo D, Capalbo A, Di Pietro C, Zuccarello D, Anastasi A, Licata E, Scarica C, Fernandez LS, Klinger FG, Italian Society of Embryology, Reproduction and Research (SIERR)

.J Assist Reprod Genet. 2020 Jul;37(7):1579-1582. doi: 10.1007/s10815-020-01813-7. Epub 2020 May 26.. 2020 doi:

The dawn of the future: 30 years from the first biopsy of a human embryo. The detailed history of an ongoing revolution.
Cimadomo D, Rienzi L, Capalbo A, Rubio C, Innocenti F, García-Pascual CM, Ubaldi FM, Handyside A

Hum Reprod Update. 2020 Jun 18;26(4):453-473. doi: 10.1093/humupd/dmaa019.. 2020 doi:

An integrated investigation of oocyte developmental competence: expression of key genes in human cumulus cells, morphokinetics of early divisions, blastulation, and euploidy.
Scarica C, Cimadomo D, Dovere L, Giancani A, Stoppa M, Capalbo A, Ubaldi FM, Rienzi L, Canipari R

J Assist Reprod Genet. 2019 May;36(5):875-887. doi: 10.1007/s10815-019-01410-3. Epub 2019 Feb 1.. 2019 doi:

Chromosome errors in human eggs shape natural fertility over reproductive life span.
Gruhn JR, Zielinska AP, Shukla V, Blanshard R, Capalbo A, Cimadomo D, Nikiforov D, Chan AC, Newnham LJ, Vogel I, Scarica C, Krapchev M, Taylor D, Kristensen SG, Cheng J, Ernst E, Bjørn AB, Colmorn LB, Blayney M, Elder K, Liss J, Hartshorne G, Grøndahl ML, Rienzi L, Ubaldi F, McCoy R, Lukaszuk K, Andersen CY, Schuh M, Hoffmann ER

Science. 2019 Sep 27;365(6460):1466-1469. doi: 10.1126/science.aav7321.. 2019 doi:

Definition and validation of a custom protocol to detect miRNAs in the spent media after blastocyst culture: searching for biomarkers of implantation.
Cimadomo D, Rienzi L, Giancani A, Alviggi E, Dusi L, Canipari R, Noli L, Ilic D, Khalaf Y, Ubaldi FM, Capalbo A

Hum Reprod. 2019 Sep 29;34(9):1746-1761. doi: 10.1093/humrep/dez119.. 2019 doi:

Embryonic cell-free DNA versus trophectoderm biopsy for aneuploidy testing: concordance rate and clinical implications.
Rubio C, Rienzi L, Navarro-Sánchez L, Cimadomo D, García-Pascual CM, Albricci L, Soscia D, Valbuena D, Capalbo A, Ubaldi F, Simón C

Fertil Steril. 2019 Sep;112(3):510-519. doi: 10.1016/j.fertnstert.2019.04.038. Epub 2019 Jun 11.. 2019 doi:

Looking past the appearance: a comprehensive description of the clinical contribution of poor-quality blastocysts to increase live birth rates during cycles with aneuploidy testing.
Cimadomo D, Soscia D, Vaiarelli A, Maggiulli R, Capalbo A, Ubaldi FM, Rienzi L

Hum Reprod. 2019 Jul 8;34(7):1206-1214. doi: 10.1093/humrep/dez078.. 2019 doi:

The main will of the patients of a private Italian IVF clinic for their aneuploid/affected blastocysts would be donation to research: a currently forbidden choice.
Faustini F, Forte M, Capalbo A, Cimadomo D, Ubaldi FM, Rienzi L

J Assist Reprod Genet. 2019 Aug;36(8):1555-1560. doi: 10.1007/s10815-019-01465-2. Epub 2019 May 27.. 2019 doi:

Time of morulation and trophectoderm quality are predictors of a live birth after euploid blastocyst transfer: a multicenter study.
Rienzi L, Cimadomo D, Delgado A, Minasi MG, Fabozzi G, Gallego RD, Stoppa M, Bellver J, Giancani A, Esbert M, Capalbo A, Remohì J, Greco E, Ubaldi FM, Meseguer M

Fertil Steril. 2019 Dec;112(6):1080-1093.e1. doi: 10.1016/j.fertnstert.2019.07.1322.. 2019 doi:

Associations of blastocyst features, trophectoderm biopsy and other laboratory practice with post-warming behavior and implantation.
Cimadomo D, Capalbo A, Levi-Setti PE, Soscia D, Orlando G, Albani E, Parini V, Stoppa M, Dovere L, Tacconi L, Ievoli E, Maggiulli R, Ubaldi FM, Rienzi L

Hum Reprod. 2018 Nov 1;33(11):1992-2001. doi: 10.1093/humrep/dey291.. 2018 doi:

Biochemical pregnancy loss after frozen embryo transfer seems independent of embryo developmental stage and chromosomal status.
Vaiarelli A, Cimadomo D, Patrizio P, Venturella R, Orlando G, Soscia D, Giancani A, Capalbo A, Rienzi L, Ubaldi FM

Reprod Biomed Online. 2018 Sep;37(3):349-357. doi: 10.1016/j.rbmo.2018.05.019. Epub 2018 Jun 30.. 2018 doi:

Diagnostic efficacy of blastocoel fluid and spent media as sources of DNA for preimplantation genetic testing in standard clinical conditions.
Capalbo A, Romanelli V, Patassini C, Poli M, Girardi L, Giancani A, Stoppa M, Cimadomo D, Ubaldi FM, Rienzi L

Fertil Steril. 2018 Oct;110(5):870-879.e5. doi: 10.1016/j.fertnstert.2018.05.031.. 2018 doi:

Inconclusive chromosomal assessment after blastocyst biopsy: prevalence, causative factors and outcomes after re-biopsy and re-vitrification. A multicenter experience.
Cimadomo D, Rienzi L, Romanelli V, Alviggi E, Levi-Setti PE, Albani E, Dusi L, Papini L, Livi C, Benini F, Smeraldi A, Patassini C, Ubaldi FM, Capalbo A

Hum Reprod. 2018 Oct 1;33(10):1839-1846. doi: 10.1093/humrep/dey282.. 2018 doi:

Prevalence of XXY karyotypes in human blastocysts: multicentre data from 7549 trophectoderm biopsies obtained during preimplantation genetic testing cycles in IVF.
Mazzilli R, Cimadomo D, Rienzi L, Capalbo A, Levi Setti PE, Livi C, Vizziello D, Foresta C, Ferlin A, Ubaldi FM

Hum Reprod. 2018 Jul 1;33(7):1355-1363. doi: 10.1093/humrep/dey110.. 2018 doi:

Abnormally fertilized oocytes can result in healthy live births: improved genetic technologies for preimplantation genetic testing can be used to rescue viable embryos in in vitro fertilization cycles.
Capalbo A, Treff N, Cimadomo D, Tao X, Ferrero S, Vaiarelli A, Colamaria S, Maggiulli R, Orlando G, Scarica C, Scott R, Ubaldi FM, Rienzi L

Fertil Steril. 2017 Dec;108(6):1007-1015.e3. doi: 10.1016/j.fertnstert.2017.08.004. Epub 2017 Sep 15.. 2017 doi:

Detecting mosaicism in trophectoderm biopsies: current challenges and future possibilities.
Capalbo A, Ubaldi FM, Rienzi L, Scott R, Treff N

Hum Reprod. 2017 Mar 1;32(3):492-498. doi: 10.1093/humrep/dew250.. 2017 doi:

Diagnosis and clinical management of duplications and deletions.
Capalbo A, Rienzi L, Ubaldi FM

Fertil Steril. 2017 Jan;107(1):12-18. doi: 10.1016/j.fertnstert.2016.11.002.. 2017 doi:

Effect of the male factor on the clinical outcome of intracytoplasmic sperm injection combined with preimplantation aneuploidy testing: observational longitudinal cohort study of 1,219 consecutive cycles.
Mazzilli R, Cimadomo D, Vaiarelli A, Capalbo A, Dovere L, Alviggi E, Dusi L, Foresta C, Lombardo F, Lenzi A, Tournaye H, Alviggi C, Rienzi L, Ubaldi FM

Fertil Steril. 2017 Dec;108(6):961-972.e3. doi: 10.1016/j.fertnstert.2017.08.033. Epub 2017 Oct 3.. 2017 doi:

Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging.
Capalbo A, Hoffmann ER, Cimadomo D, Ubaldi FM, Rienzi L

Hum Reprod Update. 2017 Nov 1;23(6):706-722. doi: 10.1093/humupd/dmx026.. 2017 doi:

Mosaicism between trophectoderm and inner cell mass.
Capalbo A, Rienzi L

Fertil Steril. 2017 May;107(5):1098-1106. doi: 10.1016/j.fertnstert.2017.03.023. Epub 2017 Apr 19. . 2017 doi:

PGS for recurrent pregnancy loss: still an open question.
Rienzi L, Capalbo A, Vajta G, Ubaldi FM

Hum Reprod. 2017 Feb;32(2):476-477. doi: 10.1093/humrep/dew311. Epub 2016 Dec 13.. 2017 doi:

Preimplantation genetic diagnosis for aneuploidy testing in women older than 44 years: a multicenter experience.
Ubaldi FM, Cimadomo D, Capalbo A, Vaiarelli A, Buffo L, Trabucco E, Ferrero S, Albani E, Rienzi L, Levi Setti PE

Fertil Steril. 2017 May;107(5):1173-1180. doi: 10.1016/j.fertnstert.2017.03.007. Epub 2017 Apr 19.. 2017 doi:

Reply: Detecting mosaicism in trophectoderm biopsies.
Capalbo A, Ubaldi F, Rienzi L, Scott R, Treff N

Hum Reprod. 2017 Mar 1;32(3):714-715. doi: 10.1093/humrep/dew347.. 2017 doi:

45,X product of conception after preimplantation genetic diagnosis and euploid embryo transfer: evidence of a spontaneous conception confirmed by DNA fingerprinting.
Bettio D, Capalbo A, Albani E, Rienzi L, Achille V, Venci A, Ubaldi FM, Levi Setti PE

Reprod Biol Endocrinol. 2016 Sep 6;14(1):55. doi: 10.1186/s12958-016-0190-9.. 2016 doi:

5,X product of conception after preimplantation genetic diagnosis and euploid embryo transfer: evidence of a spontaneous conception confirmed by DNA fingerprinting.
Bettio D, Capalbo A, Albani E, Rienzi L, Achille V, Venci A, Ubaldi FM, Levi Setti PE

Reprod Biol Endocrinol. 2016 Sep 6;14(1):55. doi: 10.1186/s12958-016-0190-9.. 2016 doi:

Artificial oocyte activation with calcium ionophore does not cause a widespread increase in chromosome segregation errors in the second meiotic division of the oocyte.
Capalbo A, Ottolini CS, Griffin DK, Ubaldi FM, Handyside AH, Rienzi L

Fertil Steril. 2016 Mar;105(3):807-814.e2. doi: 10.1016/j.fertnstert.2015.11.017. Epub 2015 Dec 1.. 2016 doi:

Consistent and reproducible outcomes of blastocyst biopsy and aneuploidy screening across different biopsy practitioners: a multicentre study involving 2586 embryo biopsies.
Capalbo A, Ubaldi FM, Cimadomo D, Maggiulli R, Patassini C, Dusi L, Sanges F, Buffo L, Venturella R, Rienzi L

Hum Reprod. 2016 Jan;31(1):199-208. doi: 10.1093/humrep/dev294. Epub 2015 Dec 4.. 2016 doi:

Electronic witness system in IVF-patients perspective.
Forte M, Faustini F, Maggiulli R, Scarica C, Romano S, Ottolini C, Farcomeni A, Palagiano A, Capalbo A, Ubaldi FM, Rienzi L

J Assist Reprod Genet. 2016 Sep;33(9):1215-22. doi: 10.1007/s10815-016-0759-4. Epub 2016 Jul 7.. 2016 doi:

Failure mode and effects analysis of witnessing protocols for ensuring traceability during PGD/PGS cycles.
Cimadomo D, Ubaldi FM, Capalbo A, Maggiulli R, Scarica C, Romano S, Poggiana C, Zuccarello D, Giancani A, Vaiarelli A, Rienzi L

Reprod Biomed Online. 2016 Sep;33(3):360-9. doi: 10.1016/j.rbmo.2016.06.002. Epub 2016 Jun 23.. 2016 doi:

Follicular versus luteal phase ovarian stimulation during the same menstrual cycle (DuoStim) in a reduced ovarian reserve population results in a similar euploid blastocyst formation rate: new insight in ovarian reserve exploitation.
Ubaldi FM, Capalbo A, Vaiarelli A, Cimadomo D, Colamaria S, Alviggi C, Trabucco E, Venturella R, Vajta G, Rienzi L

Fertil Steril. 2016 Jun;105(6):1488-1495.e1. doi: 10.1016/j.fertnstert.2016.03.002. Epub 2016 Mar 25.. 2016 doi:

Generation of meiomaps of genome-wide recombination and chromosome segregation in human oocytes.
Ottolini CS, Capalbo A, Newnham L, Cimadomo D, Natesan SA, Hoffmann ER, Ubaldi FM, Rienzi L, Handyside AH

Nat Protoc. 2016 Jul;11(7):1229-43. doi: 10.1038/nprot.2016.075. Epub 2016 Jun 16.. 2016 doi:

Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c.
Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D

Stem Cells Dev. 2016 Dec 15;25(24):1853-1862. doi: 10.1089/scd.2016.0212. Epub 2016 Oct 17.. 2016 doi:

Implementing PGD/PGD-A in IVF clinics: considerations for the best laboratory approach and management.
Capalbo A, Romanelli V, Cimadomo D, Girardi L, Stoppa M, Dovere L, Dell'Edera D, Ubaldi FM, Rienzi L

J Assist Reprod Genet. 2016 Oct;33(10):1279-1286. doi: 10.1007/s10815-016-0768-3. Epub 2016 Jul 16. . 2016 doi:

MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells and can be explored for human embryo reproductive competence assessment.
Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L

Fertil Steril. 2016 Jan;105(1):225-35.e1-3. doi: 10.1016/j.fertnstert.2015.09.014. Epub 2015 Oct 9.. 2016 doi:

New approaches for multifactor preimplantation genetic diagnosis of monogenic diseases and aneuploidies from a single biopsy.
Capalbo A, Rienzi L, Ubaldi FM

Fertil Steril. 2016 Feb;105(2):297-8. doi: 10.1016/j.fertnstert.2015.10.039. Epub 2015 Nov 21.. 2016 doi:

Pre-implantation genetic testing in ART: who will benefit and what is the evidence?
Vaiarelli A, Cimadomo D, Capalbo A, Orlando G, Sapienza F, Colamaria S, Palagiano A, Bulletti C, Rienzi L, Ubaldi FM

.J Assist Reprod Genet. 2016 Oct;33(10):1273-1278. doi: 10.1007/s10815-016-0785-2. Epub 2016 Aug 5.. 2016 doi:

The Impact of Biopsy on Human Embryo Developmental Potential during Preimplantation Genetic Diagnosis.
Cimadomo D, Capalbo A, Ubaldi FM, Scarica C, Palagiano A, Canipari R, Rienzi L

Biomed Res Int. 2016;2016:7193075. doi: 10.1155/2016/7193075. Epub 2016 Jan 28.. 2016 doi:

The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.
Sermon K, Capalbo A, Cohen J, Coonen E, De Rycke M, De Vos A, Delhanty J, Fiorentino F, Gleicher N, Griesinger G, Grifo J, Handyside A, Harper J, Kokkali G, Mastenbroek S, Meldrum D, Meseguer M, Montag M, Munné S, Rienzi L, Rubio C, Scott K, Scott R, Simon C, Swain J, Treff N, Ubaldi F, Vassena R, Vermeesch JR, Verpoest W, Wells D, Geraedts J

Mol Hum Reprod. 2016 Aug;22(8):845-57. doi: 10.1093/molehr/gaw034. Epub 2016 Jun 2. . 2016 doi:

Comparison of array comparative genomic hybridization and quantitative real-time PCR-based aneuploidy screening of blastocyst biopsies.
Capalbo A, Treff NR, Cimadomo D, Tao X, Upham K, Ubaldi FM, Rienzi L, Scott RT Jr

Eur J Hum Genet. 2015 Jul;23(7):901-6. doi: 10.1038/ejhg.2014.222. Epub 2014 Oct 29.. 2015 doi:

Developmental clock compromises human twin model created by embryo splitting.
Noli L, Dajani Y, Capalbo A, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D

Hum Reprod. 2015 Dec;30(12):2774-84. doi: 10.1093/humrep/dev252. Epub 2015 Oct 21. . 2015 doi:

Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates.
Ottolini CS, Newnham L, Capalbo A, Natesan SA, Joshi HA, Cimadomo D, Griffin DK, Sage K, Summers MC, Thornhill AR, Housworth E, Herbert AD, Rienzi L, Ubaldi FM, Handyside AH, Hoffmann ER

Nat Genet. 2015 Jul;47(7):727-735. doi: 10.1038/ng.3306. Epub 2015 May 18.. 2015 doi:

No evidence of association between blastocyst aneuploidy and morphokinetic assessment in a selected population of poor-prognosis patients: a longitudinal cohort study.
Rienzi L, Capalbo A, Stoppa M, Romano S, Maggiulli R, Albricci L, Scarica C, Farcomeni A, Vajta G, Ubaldi FM

Reprod Biomed Online. 2015 Jan;30(1):57-66. doi: 10.1016/j.rbmo.2014.09.012. Epub 2014 Oct 5.. 2015 doi:

Reduction of multiple pregnancies in the advanced maternal age population after implementation of an elective single embryo transfer policy coupled with enhanced embryo selection: pre- and post-intervention study.
Ubaldi FM, Capalbo A, Colamaria S, Ferrero S, Maggiulli R, Vajta G, Sapienza F, Cimadomo D, Giuliani M, Gravotta E, Vaiarelli A, Rienzi L

Hum Reprod. 2015 Sep;30(9):2097-106. doi: 10.1093/humrep/dev159. Epub 2015 Jul 5.. 2015 doi:

A cautionary note against embryo aneuploidy risk assessment using time-lapse imaging.
Ottolini C, Rienzi L, Capalbo A

Reprod Biomed Online. 2014 Mar;28(3):273-5. doi: 10.1016/j.rbmo.2013.10.015. Epub 2013 Oct 26.. 2014 doi:

Correlation between standard blastocyst morphology, euploidy and implantation: an observational study in two centers involving 956 screened blastocysts.
Capalbo A, Rienzi L, Cimadomo D, Maggiulli R, Elliott T, Wright G, Nagy ZP, Ubaldi FM

Hum Reprod. 2014 Jun;29(6):1173-81. doi: 10.1093/humrep/deu033. Epub 2014 Feb 26.. 2014 doi:

FISH reanalysis of inner cell mass and trophectoderm samples of previously array-CGH screened blastocysts shows high accuracy of diagnosis and no major diagnostic impact of mosaicism at the blastocyst stage.
Capalbo A, Wright G, Elliott T, Ubaldi FM, Rienzi L, Nagy ZP

Hum Reprod. 2013 Aug;28(8):2298-307. doi: 10.1093/humrep/det245. Epub 2013 Jun 5.. 2013 doi:

Reply: Questions about the accuracy of polar body analysis for preimplantation genetic screening.
Capalbo A, Bono S, Spizzichino L, Biricik A, Baldi M, Colamaria S, Ubaldi FM, Rienzi L, Fiorentino F

Hum Reprod. 2013 Jun;28(6):1733-6. doi: 10.1093/humrep/det070. Epub 2013 Mar 26.. 2013 doi:

Sequential comprehensive chromosome analysis on polar bodies, blastomeres and trophoblast: insights into female meiotic errors and chromosomal segregation in the preimplantation window of embryo development.
Capalbo A, Bono S, Spizzichino L, Biricik A, Baldi M, Colamaria S, Ubaldi FM, Rienzi L, Fiorentino F

Hum Reprod. 2013 Feb;28(2):509-18. doi: 10.1093/humrep/des394. Epub 2012 Nov 11.. 2013 doi:

Consistent and predictable delivery rates after oocyte vitrification: an observational longitudinal cohort multicentric study.
Rienzi L, Cobo A, Paffoni A, Scarduelli C, Capalbo A, Vajta G, Remohí J, Ragni G, Ubaldi FM

Hum Reprod. 2012 Jun;27(6):1606-12. doi: 10.1093/humrep/des088. Epub 2012 Mar 22.. 2012 doi:

The worldwide frozen embryo reservoir: methodologies to achieve optimal results.
Capalbo A, Rienzi L, Buccheri M, Maggiulli R, Sapienza F, Romano S, Colamaria S, Iussig B, Giuliani M, Palagiano A, Ubaldi F

Ann N Y Acad Sci. 2011 Mar;1221:32-9. doi: 10.1111/j.1749-6632.2010.05931.x.. 2011 doi:

Cumulative ongoing pregnancy rate achieved with oocyte vitrification and cleavage stage transfer without embryo selection in a standard infertility program.
Ubaldi F, Anniballo R, Romano S, Baroni E, Albricci L, Colamaria S, Capalbo A, Sapienza F, Vajta G, Rienzi L

Hum Reprod. 2010 May;25(5):1199-205. doi: 10.1093/humrep/deq046. Epub 2010 Feb 25. . 2010 doi:

Embryo development of fresh 'versus' vitrified metaphase II oocytes after ICSI: a prospective randomized sibling-oocyte study.
Rienzi L, Romano S, Albricci L, Maggiulli R, Capalbo A, Baroni E, Colamaria S, Sapienza F, Ubaldi F

Hum Reprod. 2010 Jan;25(1):66-73. doi: 10.1093/humrep/dep346. Epub 2009 Oct 27.. 2010 doi:

Presentations

Rienzi L Cimadomo D Delgado A Minasi MG Fabozzi G Del Gallego R Stoppa M Bellver J Giancani A Esbert M Capalbo A Remohí J Greco E Ubaldi F Meseguer M O-006: Time of morulation and trophectoderm quality are associated with live birth after euploid blastocyst transfer: a multicenter study. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver,CO,USA, 23-26 June 2019

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