Ana Cobo, Ph.D.

Director of the Cryobiology Unit in the IVF lab at IVI Valencia

IVI Valencia

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Ana Cobo, Ph.D.

Biography

Dr. Ana Cobo graduated from the University del Valle in Colombia in 1988. She obtained her Master’s degree in Biological Sciences in Reproduction Biology at the University of Chile in 1994. She moved to Spain in 1995, when she joined the Instituto Valenciano de Infertilidad (IVI). She then obtained a second Master’s degree in Human Reproduction in 1998, and received her Ph.D. degree in 2008, both from the University of Valencia, Spain.

Dr. Cobo has worked as an embryologist for more than 20 years and became interested in oocyte cryopreservation in the early 1990s, while conducting her Master’s degree and doctoral thesis research. She is currently a senior embryologist at the IVI RMA Valencia, where she is the Director of the Cryobiology Unit in the IVF lab. Her work in the clinical application of oocyte vitrification has made a great impact on assisted reproduction. She was a pioneer in the large-scale application of oocyte cryopreservation, demonstrating the efficiency of egg-banking. Her work has been very useful for both clinicians and patients interested in preserving fertility. Her publications provide the largest database assessing the scope of oocyte vitrification as a tool for the preservation of fertility and for ovum donation, focusing on the number of vitrified oocytes required to get a baby.

She has participated as the Primary Investigator (lead researcher) in a number of research projects (PROFIT MITYC 2005, IMPIVA I+D 2006, CDTI 2005-2007, IMPIVA 2007, IMPIVA 2008), and published over 50 original articles. In addition, she wrote or co-wrote more than 50 book chapters, co-edited 4 books, and had more than 100 presentations in international meetings. She has been invited to speak nationally and internationally, and she is member of several professional organizations including American Society for Reproductive Medicine (ASRM), European Society of Human Reproduction and Embryology (ESHRE), and Sociedad Española de Fertilidad (SEF).

Her teaching activities focus on directing the continuous training program in the vitrification of oocytes and embryos at the IVI learning center. She also serves as teaching faculty for the postgraduate Master’s course in Biotechnology of Human Reproduction at the IVI University Institute since 1997, ascribed to the University of Valencia.


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Education and Training

BS University del Valle, Colombia (1998)
M.Sc. University of Chile, Chile (1994)
M.Sc. (Human Reproduction) University of Valencia, Spain (1998)
Ph.D. (Biology) University of Valencia, Spain (2008)
Fellowship IVI Valencia, Spain (1995-1997)

Honors and recognition

ASRM Star Award 2017
CRIO MERCK SERONO-ASEBIR Award 2015

Publications


  • Optimizing the culture environment and embryo manipulation to help maintain embryo developmental potential.
    Swain JE, Carrell D, Cobo A, Meseguer M, Rubio C, Smith GD.
    Fertil Steril, 105:571-87, 2016.

  • Impact of vitrification on the mitochondrial activity and redox homeostasis of human oocyte.
    Nohales-Corcoles M, Sevillano-Almerich G, Di Emidio G, Tatone C, Cobo AC, Dumollard R, De Los Santos Molina MJ.
    Hum Reprod, 31:1850-8, 2016.

  • A combination of hydroxypropyl cellulose and trehalose as supplementation for vitrification of human oocytes: a retrospective cohort study.
    Coello A, Campos P, Remohi J, Meseguer M, Cobo A.
    J Assist Reprod Genet, 33:413-21, 2016.


  • Oocyte vitrification as an efficient option for elective fertility preservation.
    Cobo A, Garcia-Velasco JA, Coello A, Domingo J, Pellicer A, Remohi J.
    Fertil Steril, 105:755-64 e8, 2016.

  • Why all women should freeze their eggs.
    Cobo A, Garcia-Velasco JA.
    Curr Opin Obstet Gynecol, 28:206-10, 2016.

  • Fertility preservation for age-related fertility decline - authors' reply.
    Stoop D, Silber S, Cobo A.
    Lancet, 385:507-8, 2015.

  • Six years' experience in ovum donation using vitrified oocytes: report of cumulative outcomes, impact of storage time, and development of a predictive model for oocyte survival rate.
    Cobo A, Garrido N, Pellicer A, Remohi J.
    Fertil Steril, 104:1426-34 e1-8, 2015.

  • Fertility preservation for age-related fertility decline.
    Stoop D, Cobo A, Silber S.
    Lancet, 384:1311-9, 2014.

  • New tools for embryo selection: comprehensive chromosome screening by array comparative genomic hybridization.
    Rodrigo L, Mateu E, Mercader A, Cobo AC, Peinado V, Milan M, Al-Asmar N, Campos-Galindo I, Garcia-Herrero S, Mir P, Simon C, Rubio C.
    Biomed Res Int, 2014:517125, 2014.

  • Obstetric outcome after oocyte vitrification and warming for fertility preservation in women with cancer.
    Martinez M, Rabadan S, Domingo J, Cobo A, Pellicer A, Garcia-Velasco JA.
    Reprod Biomed Online, 29:722-8, 2014.

  • Oocyte versus embryo vitrification for delayed embryo transfer: an observational study.
    Herrero L, Pareja S, Aragones M, Cobo A, Bronet F, Garcia-Velasco JA.
    Reprod Biomed Online, 29:567-72, 2014.

  • Obstetric and perinatal outcome of babies born from vitrified oocytes.
    Cobo A, Serra V, Garrido N, Olmo I, Pellicer A, Remohi J.
    Fertil Steril, 102:1006-15 e4, 2014.

  • Five years' experience using oocyte vitrification to preserve fertility for medical and nonmedical indications.
    Garcia-Velasco JA, Domingo J, Cobo A, Martinez M, Carmona L, Pellicer A.
    Fertil Steril, 99:1994-9, 2013.

  • Bed rest after embryo transfer negatively affects in vitro fertilization: a randomized controlled clinical trial.
    Gaikwad S, Garrido N, Cobo A, Pellicer A, Remohi J.
    Fertil Steril, 100:729-35, 2013.

  • Effect of vitrification on human oocytes: a metabolic profiling study.
    Dominguez F, Castello D, Remohi J, Simon C, Cobo A.
    Fertil Steril, 99:565-72, 2013.

  • Is vitrification of oocytes useful for fertility preservation for age-related fertility decline and in cancer patients?
    Cobo A, Garcia-Velasco JA, Domingo J, Remohi J, Pellicer A.
    Fertil Steril, 99:1485-95, 2013.

  • Outcome of cryotransfer of embryos developed from vitrified oocytes: double vitrification has no impact on delivery rates.
    Cobo A, Castello D, Vallejo B, Albert C, de los Santos JM, Remohi J.
    Fertil Steril, 99:1623-30, 2013.

  • Comparison of Cryotip vs. Cryotop for mouse and human blastomere vitrification.
    Valbuena D, Poo ME, Aguilar-Gallardo C, Martinez S, Cobo AC, Pellicer A, Simon C.
    Fertil Steril, 97:209-17, 2012.

  • Consistent and predictable delivery rates after oocyte vitrification: an observational longitudinal cohort multicentric study.
    Rienzi L, Cobo A, Paffoni A, Scarduelli C, Capalbo A, Vajta G, Remohi J, Ragni G, Ubaldi FM.
    Hum Reprod, 27:1606-12, 2012.

  • Accumulation of oocytes: a new strategy for managing low-responder patients.
    Cobo A, Garrido N, Crespo J, Jose R, Pellicer A.
    Reprod Biomed Online, 24:424-32, 2012.

  • Outcomes of vitrified early cleavage-stage and blastocyst-stage embryos in a cryopreservation program: evaluation of 3,150 warming cycles.
    Cobo A, de los Santos MJ, Castello D, Gamiz P, Campos P, Remohi J.
    Fertil Steril, 98:1138-46 e1, 2012.

  • Viral screening of spent culture media and liquid nitrogen samples of oocytes and embryos from hepatitis B, hepatitis C, and human immunodeficiency virus chronically infected women undergoing in vitro fertilization cycles.
    Cobo A, Bellver J, de los Santos MJ, Remohi J.
    Fertil Steril, 97:74-8, 2012.

  • Oocyte vitrification: a watershed in ART.
    Cobo A.
    Fertil Steril, 98:600-1, 2012.

  • The Alpha consensus meeting on cryopreservation key performance indicators and benchmarks: proceedings of an expert meeting.
    Bianchi V BV, Cobo A, Ebner T, Edgar D, Greuner M, Leibo S, Mortimer D, Nagy ZP, Parmegiani L, Roy T, Street K, Thornhill A, Van Landuyt L, Vanderzwalmen P, VerMilyea MT, Wood M.
    Reprod Biomed Online, 25:146-67, 2012.

  • Vitrification versus slow freezing of oocytes: effects on morphologic appearance, meiotic spindle configuration, and DNA damage.
    Martinez-Burgos M, Herrero L, Megias D, Salvanes R, Montoya MC, Cobo AC, Garcia-Velasco JA.
    Fertil Steril, 95:374-7, 2011.

  • Avoiding the use of human chorionic gonadotropin combined with oocyte vitrification and GnRH agonist triggering versus coasting: a new strategy to avoid ovarian hyperstimulation syndrome.
    Herrero L, Pareja S, Losada C, Cobo AC, Pellicer A, Garcia-Velasco JA.
    Fertil Steril, 95:1137-40, 2011.

  • Oocyte cryopreservation for donor egg banking.
    Cobo A, Remohi J, Chang CC, Nagy ZP.
    Reprod Biomed Online, 23:341-6, 2011.

  • Clinical application of oocyte vitrification: a systematic review and meta-analysis of randomized controlled trials.
    Cobo A, Diaz C.
    Fertil Steril, 96:277-85, 2011.

  • Embryo culture: can we perform better than nature?
    Vajta G, Rienzi L, Cobo A, Yovich J.
    Reprod Biomed Online, 20:453-69, 2010.

  • Twins born after transplantation of ovarian cortical tissue and oocyte vitrification.
    Sanchez-Serrano M, Crespo J, Mirabet V, Cobo AC, Escriba MJ, Simon C, Pellicer A.
    Fertil Steril, 93:268 e11-3, 2010.

  • Redefining advanced maternal age as an indication for preimplantation genetic screening.
    Milan M, Cobo AC, Rodrigo L, Mateu E, Mercader A, Buendia P, Peinado V, Delgado A, Mir P, Simon C, Remohi J, Pellicer A, Rubio C.
    Reprod Biomed Online, 21:649-57, 2010.

  • Storage of human oocytes in the vapor phase of nitrogen.
    Cobo A, Romero JL, Perez S, de los Santos MJ, Meseguer M, Remohi J.
    Fertil Steril, 94:1903-7, 2010.

  • Use of cryo-banked oocytes in an ovum donation programme: a prospective, randomized, controlled, clinical trial.
    Cobo A, Meseguer M, Remohi J, Pellicer A.
    Hum Reprod, 25:2239-46, 2010.

  • Vitrification in assisted reproduction: myths, mistakes, disbeliefs and confusion.
    Vajta G, Nagy ZP, Cobo A, Conceicao J, Yovich J.
    Reprod Biomed Online, 19 Suppl 3:1-7, 2009.

  • New approaches to female fertility preservation.
    Domingo J, Ayllon Y, Domingo S, Cobo A, Crespo J, Pellicer A.
    Clin Transl Oncol, 11:154-9, 2009.

  • Vitrification of human mature oocytes in clinical practice.
    Cobo A, Vajta G, Remohi J.
    Reprod Biomed Online, 19 Suppl 4:4385, 2009.

  • Effect of different cryopreservation protocols on the metaphase II spindle in human oocytes.
    Cobo A, Perez S, De los Santos MJ, Zulategui J, Domingo J, Remohi J.
    Reprod Biomed Online, 17:350-9, 2008.

  • Comparison of concomitant outcome achieved with fresh and cryopreserved donor oocytes vitrified by the Cryotop method.
    Cobo A, Kuwayama M, Perez S, Ruiz A, Pellicer A, Remohi J.
    Fertil Steril, 89:1657-64, 2008.
    Vitrification: an effective new approach to oocyte banking and preserving fertility in cancer patients.
    Cobo A, Domingo J, Perez S, Crespo J, Remohi J, Pellicer A.
    Clin Transl Oncol, 10:268-73, 2008.

  • New options in assisted reproduction technology: the Cryotop method of oocyte vitrification.
    Cobo A, Bellver J, Domingo J, Perez S, Crespo J, Pellicer A, Remohi J.
    Reprod Biomed Online, 17:68-72, 2008.

  • Effect of a sharp serum oestradiol fall before HCG administration during ovarian stimulation in donors.
    Cobo A, Bosch E, Alvarez C, de los Santos MJ, Pellicer A, Remohi J.
    Reprod Biomed Online, 15:169-74, 2007.

  • Endocrinological and ultrasonographic variations after immature oocyte retrieval in a natural cycle.
    Requena A, Neuspiller F, Cobo AC, Aragones M, Garcia-Velasco JA, Remohi J, Simon C, Pellicer A.
    Hum Reprod, 16:1833-7, 2001.

  • Use of fluorescence in situ hybridization to assess the chromosomal status of embryos obtained from cryopreserved oocytes.
    Cobo A, Rubio C, Gerli S, Ruiz A, Pellicer A, Remohi J.
    Fertil Steril, 75:354-60, 2001.

  • The potential use of maturation in vitro of human oocytes in low responder patients.
    Requena A, Neuspiller F, Cobo AC, Aragones M, Remohi J, Simon C, Pellicer A.
    J Assist Reprod Genet, 17:239-44, 2000.

  • Maturation in vitro of human oocytes from unstimulated cycles: selection of the optimal day for ovum retrieval based on follicular size.
    Cobo AC, Requena A, Neuspiller F, Aragon s M, Mercader A, Navarro J, Simon C, Remohi J, Pellicer A.
    Hum Reprod, 14:1864-8, 1999.

  • Vantman D. [Contribution of chromosomal abnormalities to in vitro fertilization failures].
    Smith R, Walker L, Cobo A.
    Rev Med Chil, 126:511-9, 1998.


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Videos

Oocyte cryopreservation: transition from experimental to mainstream
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