Ernesto Bosch, M.D., Ph.D.

Medical Director of the Human Reproduction Unit of the IVI Valencia

IVI Valencia

Biography

Dr. Ernesto Bosch is the Medical Director of the Human Reproduction Unit of the IVI Valencia and University of Valencia, Spain. Ernesto Bosch was born in Philadelphia, USA. He completed Medical School at the University of Valencia in 1992 and from 1993 to 1997, did his Residency in Obstetrics and Gynaecology at Hospital La Fe, Valencia. Dr. Bosch trained in Human Reproduction at the Hospital of the University of Pennsylvania in 1997; and in 1999, he completed his doctoral thesis on the influence of LH on oocyte quality, with “cum laude” qualification, at the University of Valencia. In January 2000, Ernesto joined the team at the Human Reproduction Unit of the Instituto Valenciano de Infertilidad (IVI) in Valencia; and in 2008 he obtained Master’s Degree in Research on Health Sciences, by the Autonomous University if Barcelona.

Dr. Bosch has published 52 papers in peer reviewed journals and written more than 50 book chapters in the field of IVF; has given over 200 lectures at international meetings around the world. He belongs to the Editorial Board of Fertility and Sterility, and Reproductive Biomedicine Online and is a regular reviewer for Human Reproduction, and Reproductive Biology and Endocrinology among others. He belonged to the Special Interest Group on Reproductive Endocrinology of the Spanish Fertility Society, and currently to the Special Interest Group on Reproductive Endocrinology of ESHRE. He was the National Representative of the Spanish clinicians at the ESHRE committee between 2014 and 2016. He received the Scientific Program Prize Paper Award at the 2008 Annual Meeting of the American Society for Reproductive Medicine. In May 2010, Dr. Bosch was appointed Medical Director of the Human Reproduction Unit of the Instituto Valenciano de Infertilidad in Valencia.

M.D.. University of Valencia Medical School	1992
General Physician. Hospital Clínico Universitario. Valencia	1993
Residency Obstetrics and Gynaecology. Hospital Universitario La Fe. Valencia	1994-1997
Doctoral Courses. University of Valencia	1995-1996
Clinical Fellowship on Human Reproduction at The Hospital of the University of Pennsylvania. Philadelphia. USA	1997
Staff at the Human Reproduction unit. Hospital Universitario La Fe. Valencia	1998
Statistical Methods in Health Sciences. (300 hours). Universidad Autónoma de Barcelona	1997-1998
Postdoctoral Research under the direction of Prof. Alberto Romeu from Hospital Universitario La Fe of Valencia, and Prof. Luis Blasco from The Hospital of The University of Pennsylvania, Philadelphia, USA	1999
1999-2000: Multivariate Analysis (240 hours). Universidad Autónoma de Barcelona	1999-2000
European Diplomat in Gynecological Endoscopy. Universidad de Alcalá de Henares, and University of Clermont-Ferrand 2008: Master on Design of Research projects. Universidad Autónoma de Barcelona	2008

Honors and recognition

ASRM General Program Paper Prize.

2008

Publications

Second-generation preimplantation genetic testing for aneuploidy in assisted reproduction: a SWOT analysis.
Bellver J Bosch E Espinós J García-Velasco JA Fabregues F Fontes J Llácer J Requena A Checa MA
Reprod Biomed Online. 2019 Aug 13. pii: S1472-6483(19)30695-9. doi: 10.1016/j.rbmo.2019.07.037. [Epub ahead of print] Review.

Correction to: ICSI does not offer any benefit over conventional IVF across different ovarian response categories in non-male factor infertility: a European multicenter analysis.
Drakopoulos P Garcia-Velasco JA Bosch E Blockeel C De Vos M Santos-Ribeiro S Makrigiannakis A Tournaye H Polyzos NP
J Assist Reprod Genet. 2019 Oct;36(10):2077-2078. doi: 10.1007/s10815-019-01586-8.

ICSI does not offer any benefit over conventional IVF across different ovarian response categories in non-male factor infertility: a European multicenter analysis.
Drakopoulos P García-Velasco JA Bosch E Blockeel C De Vos M Santos-Ribeiro S Makrigiannakis A Tournaye H Polyzos NP
J Assist Reprod Genet. 2019 Aug 22. doi: 10.1007/s10815-019-01563-1. [Epub ahead of print]

Activin and inhibin A in predicting outcome of pregnancies of unknown location after ART
Giles J Vidal C Pellicer A Bosch E
Medicina Reproductiva y Embriología Clínica, 5(3):109-115, 2018.

How time to healthy singleton delivery could affect decision-making during infertility treatment: a Delphi consensus.
Bosch E Bulletti C Copperman AB Fanchin R Yarali H Petta CA Polyzos NP Shapiro D Ubaldi FM García-Velasco JA Longobardi S D'Hooghe T Humaidan P Delphi TTP Consensus Group
Reprod Biomed Online, NA:NA -NA, 2018.

Activin and inhibin A in predicting outcome of pregnancies of unknown location after ART
Giles J Vidal C Pellicer A Bosch E
Medicina Reproductiva y Embriología Clínica, 5(3):109-115, 2018.

Hysteroscopic septum resection and reproductive medicine: A SWOT analysis.
Spanish Infertility SWOT Group (SISG) Checa MA Bellver J Bosch E Espinós JJ Fabregues F Fontes J García-Velasco JA Requena A
Reprod Biomed Online, 37(6):709-715, 2018.

Follitropin delta in repeated ovarian stimulation for IVF: a controlled, assessor-blind Phase 3 safety trial.
Bosch E Havelock J Martin FS Rasmussen BB Klein BM Mannaerts B Arce JC ESTHER-2 Study Group
Reprod Biomed Online, NA:NA-NA, 2018.

Conventional versus minimal ovarian stimulation: an intra-patient comparison of ovarianresponse in poor-responder women according to Bologna Criteria.
Labarta E Marin D Remohí J Bosch E
Reprod Biomed Online, 37(4):434-441, 2018.

Cumulative live birth rates according to the number of oocytes retrieved following the first ovarian stimulation for IVF/ICSI: A multicentre multinational analysis including ~15.000 women.
Polyzos NP Drakopoulos P Parra J Pellicer A Santos-Ribeiro S Tournaye H Bosch E García-Velasco JA
Fertil Steril, 110(4):661-670, 2018.

The Effect of Dose Adjustments in a Subsequent Cycle of Women With Suboptimal Response Following Conventional Ovarian Stimulation
Drakopoulos P Santos-Ribeiro S Bosch E García-Velasco JA Blockeel C Romito A Tournaye H Polyzos NP
Front Endocrinol (Lausanne), 9:361-361, 2018.

Premature progesterone elevation: targets and rescue strategies.
Lawrenz B Labarta E Fatemi HM Bosch E
Fertil Steril, 109(4):577-582, 2018.

Corrigendum: Letter to the Editor: Individualized FSH dosing improves safety and reduces iatrogenic poor response while maintaining live-birth rates.
La Marca A Blockeel Bosch E Fanchin R Fatemi HM Fauser BC García-Velasco JA Humaidan P Tarlatzis BC Nelson SM
Hum Reprod, 33(7):1372-1372, 2018.

Recombinant luteinizing hormone supplementation in assisted reproductive technology: a systematic review.
Alviggi C Conforti A Esteves SC Andersen CY Bosch E Bühler K Ferraretti AP De Placido G Mollo A Fischer R Humaidan P
Fertil Steril, 109(4):644 -664, 2018.

Individualized FSH dosing improves safety and reduces iatrogenic poor response while maintaining live-birth rates.
La Marca A Blockeel C Bosch E Fanchin R Fatemi HM Fauser BC García-Velasco JA Humaidan P Tarlatzis BC Nelson SM
Hum Reprod, 33(5):982-983, 2018.

A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of EuploidEmbryos.
Labarta E Bosch E Mercader A Alamá P Mateu E Pellicer A
Biomed Res Int. Received 13 November 2016; Accepted 23 February 2017; Published 27 March 2017

Does cumulative live birth plateau beyond a certain ovarian response?
Bosch E Labarta E Pellicer A
Fertil Steril. 2017 Dec;108(6):943. doi: 10.1016/j.fertnstert.2017.10.013. No abstract available.

A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of EuploidEmbryos.
Labarta E Bosch E Mercader A Alamá P Mateu E Pellicer A
Biomed Res Int. Received 13 November 2016; Accepted 23 February 2017; Published 27 March 2017

Corrigendum to "A Higher Ovarian Response after Stimulation for IVF Is Related to a Higher Number of Euploid Embryos".
Labarta E Bosch E Mercader A Alama P Mateu E Pellicer A
Biomed Res Int. 2017;2017:1718068. doi: 10.1155/2017/1718068. Epub 2017 Jul 13.

Low serum progesterone on the day of embryo transfer is associated with a diminished ongoing pregnancy rate in oocyte donation cycles after artificial endometrial preparation: a prospective study.
Labarta E Mariani G Holtmann N Celada P Remohí J Bosch E
Hum Reprod. 2017 Oct 13:1-6. doi: 10.1093/humrep/dex316. [Epub ahead of print]

Corrigendum: Low serum progesterone on the day of embryo transfer is associated with a diminished ongoing pregnancy rate in oocyte donation cycles after artificial endometrial preparation: a prospecti
Labarta E Mariani G Holtmann N Celada P Remohí J Bosch E
Hum Reprod. 2017 Nov 21:1. doi: 10.1093/humrep/dex353. [Epub ahead of print] No abstract available.

Regimen of ovarian stimulation affects oocyte and therefore embryo quality.
Bosch E Labarta E Kolibianakis E Rosen M Meldrum D
Fertil Steril, 105(3):560-570, 2016.

Comparative study of highly purified HMG versus recombinant FSH + recombinant LH in ovulation induction for intrauterine insemination: A randomized controlled trial.
Labarta E Bosch E
Medicina Reproductiva y Embriología Clínica, 3: 4-11, 2016.

Follicular and endocrine dose responses according to anti-Mullerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049).
Bosch E Nyboe Andersen A García-Velasco JA Sutter P Fernández-Sánchez M Visnova H Klein BM Mannaerts B Arce JC
Clin Endocrinol, 83 (6): 902-912, 2015

The necessity to define the sub-optimal responders.
García-Velasco JA Bosch E
Hum Reprod, 30(12):29-58, 2015.

Comprehensive carrier genetic test using next-generation deoxyribonucleic acid sequencing in infertile couples wishing to conceive through assisted reproductive technology
Martin J Asan Y Alberola T Rodríguez-Iglesias B Jiménez-Almazán J Li Q Du H Alama P Ruiz A Bosch E Garrido N Simón C
Fertil Steril, 104(5):1286-93, 2015.

Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049).
Bosch E Nyboe Andersen A Barri P García-Velasco JA de Sutter P Fernández-Sánchez M Visnova H Klein BM Mannaerts B Arce JC
Clin Endocrinol (Oxf). 83:902-12, 2015.

The time to prevent mendelian genetic diseases from donated or own gametes has come.
Garrido N Bosch E Alamá P Ruiz A
Fertil Steril, 104:833-835, 2015.

Comprehensive carrier genetic test using next-generation deoxyribonucleic acid sequencing in infertile couples wishing to conceive through assisted reproductive technology.
Martin J Asan Yi Y Alberola T Rodríguez-Iglesias B Jiménez-Almazán J Li Q Du H Alama P Ruiz A Bosch E Garrido N Simón C
Fertil Steril, 104:1286-1293, 2015.

Reply: Endometrial scratching for women with repeated implantation failure.
Simón C Bosch E Bellver J
Hum Reprod, 29: 2856-7, 2014.

High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study.
Requena A Cruz M Bosch E Meseguer M García-Velasco JA
Reprod Biol Endocrinol 2014; 26:69

Ovarian response to recombinant human follicle-stimulating hormone: a randomized, antimüllerian hormone-stratified, dose-response trial in women undergoing in vitro fertilization/intracytoplasmic sper
Arce JC Andersen AN Fernández-Sánchez M Visnova H Bosch E García-Velasco JA Barri P de Sutter P Klein BM Fauser BC
Fertil Steril. 102:1633-40, 2014.

Impact of ovarian stimulation with gonadotrophins on embryo aneuploidy.
Labarta E Bosch E Pellicer A
Hum Reprod Update, 20 (6): 294, 2014.

Treatment of Luteal Phase Defects in Assisted Reproduction.
Muñoz E Taboas E Portela S Aguilar J Fernandez I Muñoz L Bosch E
Curr Drug Targets. Jul; 14(8):832-42, 2013.

Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials.
Rubio C Bellver J Rodrigo L Bosch E Mercader A Vidal C De Los Santos MJ Giles J
Fertil Steril, 99(5):1400-7, 2013

Treatment of Luteal Phase Defects in Assisted Reproduction. Current Drug Targets.
Muñoz E Taboas E Portela S Aguilar J Fernández I Muñoz L Bosch E
Benthan Science Publishers. 14:832-842, 2013.

The follicular hormonal profile in low-responder patients undergoing unstimulated cycles: is it hypoandrogenic?
De Los Santos MJ García-Laez V Beltrán D Labarta E Zuzuarregui JL Alamá P Gámiz P Crespo J Bosch E Pellicer A
Hum Reprod, 28 (1): 224-229, 2013.

The role of LH in Ovarian Stimulation.
Muñoz E Bosch E Fernández E Portela S Ortiz G Remohí J Pellicer A
Current Pharmaceutical Biotechnology. 13:409-416, 2012.

Consistent and predictable delivery rates after oocyte vitrification: an observationallongitudinal cohort multicentric study.
Muñoz E Bosch E Fernandez I Portela S Ortiz G Remohí J Pellicer A
Hum Reprod, 13(3):409-16; 2012.

Impact of luteinizing hormone administration on gonadotropina-releasing hormons antagonist cycles: ana ge-adjusted analysis.
Bosch E Labarta E Crespo J Simón C Remohí J Pellicer A
Fertil Steril, 95(3):1031-6, 2011.

GnRH agonist administration at the time of implantation does not improve pregnancy outcome in intrauterine insemination cycles: a randomized controlled tria
Bellver J E Labarta Bosch E Melo MAB Vidal C Remohí J Pellice A
Fertil Steril 94(3):1065-71, 2010.

GnRH agonist administration at the time of implantation does not improve pregnancy outcome in intrauterine insemination cycles: a randomized controlled trial.
Bellver J Labarta E Bosch E Melo MAB Vidal C Remohí J Pellicer A
Fertil Steril 94(3):1065-71, 2010.

The use of prediction models of spontaneous pregnancy in in vitro fertilization units reveals differences between the expected results of public and private clinics in Spain.
Gabbanini M Privitera L Monzó A Higueras G Fuster S Garrido N Bosch E Pellicer A
Fertil Steril, 94:2376-2378, 2010.

Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for análisis of over 4000 cycles-
Bosch E Labarta E Crespo J Simón C Remohí J Jenkins J Pellicer A
Human Reprod, 25(8):2092-100;2010.

Highly purified hMG versus recombinant FSH in ovarian hyperstimulation with GnRH antagonists—a randomized stud
Bosch E Vidal C Labarta E Simón C Remohí J Pellicer A
Hum. Reprod, 23: 2346 – 2351, 2008.

Highly purified hMG versus recombinant FSH in ovarian hyperstimulation with GnRH antagonists—a randomized study.
Bosch E Vidal C Labarta E Simón C Remohí J Pellicer A
Hum. Reprod, 23: 2346 – 2351, 2008.

Clinical Factors affecting endometrial receptiveness in oocyte donation cycles.
Soares SR García-Velasco JA Fernández-Sánchez M Bosch E Remohí J Pellicer A Simón C
Fertil Steril, 89(3):491-501, 2008

Obesity and poor reproductive outcome: the potential role of the endometrium.
Bellver J Melo MA Bosch E Serra V Remohí J Pellicer A
Fertil Steril, 88:446-51, 2007.

Delaying the initiation of progesterone supplementation until the day of fertilization does not compromise cycle outcome in patients receiving donated oocytes: a randomized study.
Escribà MJ Bellver J Bosch E Sánchez M Pellicer A Remohí J
Fertil Steril, 86:92-7, 2006.

The significance of premature luteinization in an oocyte-donation programme.
Melo MAB Meseguer M Garrido N Bosch E Pellicer A Remohí J
Hum Reprod, 21:1503-1507, 2006.

Similar endometrial development in oocyte donors treated with either high- or standard-dose GnRH antagonist compared to treatment with a GnRH agonist or in natural cycles.
Simón C Oberyé J Bellver J Vidal C Bosch E Horcajadas JA Murphy C Adams S Riesewijk A Mannaerts B Pellicer A
Human Reprod, 20 (12): 3318-3327, 2005.

Evidence-based medicine is gaining momentum.
Bellver J Bosch E Remohí J Pellicer A
Fertil Steril, 84:1555-6, 2005.

Age and uterine receptiveness: predicting the outcome of oocyte donation cycles.
Soares SR Troncoso C Bosch E Serra V Simón C Remohí J Pellicer A
J Clin Endocrinol Metab, 90(7):4399-404, 2005.

BMI--the fragility of fertility.
Bellver J Bosch E Pellicer A
Fertil Steril, 81:727, 2004.

Intravenous albumin does not prevent moderate-severe ovarian hyperstimulation syndrome in high-risk IVF patients: a randomized controlled study.
Bellver J Muñoz E Ballesteros A Soares SR Bosch E Simón C Pellicer A Remohí J
J. Hum Reprod; 18:2283-8, 2003.

Obesity and the risk of spontaneous abortion after oocyte donation.
Bellver J Rossal LP Bosch E Zúñiga A Corona JT Meléndez F Gómez E Simón C Remohí J Pellicer A
Fertil Steril, 79:1136-40, 2003.

Endometrial quality in infertile women with endometriosis.
Pellicer A Navarro J Bosch E Garrido N García-Velasco JA Remohí J Simón C
Ann N Y Acad Sci. 943:122-30, 2001.

Labarta E Mariani G Bosch E P-160 Predictive value of serum progesterone level on day 4, day 7 and day 11 after blastocyst transfer in a hormonal replacement therapy cycle. . Presented at 75th American Society of Reproductive Medicine Scientific Congress, Philadelphia, PA. USA, 14-16 October 2019

Doblinger J Labarta E Bosch E P-141 Endometrial thickness in prediction of pregnancy outcome in fresh egg donation cycles: a retrospective cohort analysis. Presented at 75th American Society of Reproductive Medicine Scientific Congress, Philadelphia, PA. USA, 14-16 October 2019

Bosch E Aasted H Klein BM Arce JC P-182 A randomized, doble-blind, placebo-controlled, multi-center, phase 2 trial to investigate the effect of barusiban on implantation in IVF/ICSI patients. Presented at 75th American Society of Reproductive Medicine Scientific Congress, Philadelphia, PA. USA, 14-16 October 2019

Labarta E Mariani G Paolelli S Vidal C Giles J Bellver J Cruz F Marzal A Celada p Olmo I Alamá P Remohí J Bosch E O-173: A large prospective trial in unselected population confirms that low serum progesterone on the day of embryo transfer impairs pregnancy outcome in artificial cycles.. Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology, Vienna, Austria, 23-26 June 2019

Bosch E Alamá P Romero J Mari M Labarta E O-239: Follicular steroidogenesis in GnRH antagonist ovarian stimulation cycles with r-FSH vs. hp-HMG. A randomized controlled trial. Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology, Vienna, Austria, 23-26 June 2019

Drakopoulos P Garcia-Velasco JA Bosch E Blockeel C De Vos M Tournaye H Polyzos N O-228: ICSI does not offer any benefit over conventional IVF across different ovarian response categories: a European multicenter analysis. Presented at annual meeting of the 66th European Society of Human Reproduction and Embryology, Vienna, Austria, 23-26 June 2019

Labarta E Mariani Paolelli S Vidal C Giles J Marzal A Bellver J Cruz F Olmo I Alama P Celada P Bosch E Impact of serum progesterone levels on the day of embryo transfer in artificial endometrial preparation cycles on the ongoing pregnancy rate. An interim analysis. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver, CO, USA, October 6-10, 2018

Polyzos N Drakopoulos P Tournaye H Schiettecatte J Anckaert E Donner H Bobba G Miles G Verhagen-Kamerbeek W Bosch E Estradiol and progesterone in in vitro fertilization (esprit): evaluation of the third versus second generation estradiol and progesterone elecsys assays. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver, CO, USA, October 6-10, 2018

Bosch E Labarta E Zuzuarregui J Iliodromiti S Nelson SM Prediction of ovarian response with an automated amh assay (elecsys) in gnrh antagonist cycles. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver, CO, USA, October 6-10, 2018

Bosch E Howles C No difference in clinical outcomes using follitropin alfa (biosimilar) compared to follitropin alfa or follitropin beta for controlled ovarian stimulation (cos) in oocyte donation-recipient cycles. Presented at the 74th Scientific Congress & Expo of the American Society for Reproductive Medicine, Denver, CO, USA, October 6-10, 2018

Basile N Aparicio Ruiz B Alegre L Bosch E Pellicer A Meseguer M Laboratory strategies: canweachieve the same results doing pseudo undisturbed culture in a conventional incubator vs real undisturbed culture in 3 different time-lapse systems? 2018

Sakkas D Atkinson L Borini A Bosch E Bryce C Cattoli M Finet de Bantel A French B Gaitonde S Gerris J Granger S Grzegorczk-Martin V Howles C Somers S Alper M Can "patient-friendly" salivary hormone measurements replace serum monitoring of IVF 2018

Fatemi H Griesinger G Teal V Polyzos N Bosch E Johnson B Dos Santos S Garcia Velasco J Stoop D FSH exposure between day 8 and day of Hcg administration is an independent predictor of serum progesterone rise 2018

Labarta E Mariani G Holtmann N Celada P Remohí J Bosch E Low serum Progesterone the day of embryo transfer is associated with diminished ongoing pregnancy rate in artificial endometrial preparation cycles. A prospective study 2017

Polyzos NP Drakopoulos P Parra J Pellicer A Tournaye H Bosch E Garcia Velasco J Cumulative live birth rates following the first ovarian stimulation for IVF/ICSI. A European multicenter analysis of ~15.000 women using individual patient data 2017

Ernesto Bosch, M.D., Ph.D.

Biography

Education and Training

Honors and recognition

Publications

Presentations

Videos