Ernesto Bosch, M.D., Ph.D.

Medical Director of the Human Reproduction Unit of the IVI Valencia

IVI Valencia

Ernesto Bosch, M.D., Ph.D.

Biography

Dr. Ernesto Bosch is the Medical Director of the Human Reproduction Unit of the IVI Valencia and University of Valencia, Spain. Ernesto Bosch was born in Philadelphia, USA. He completed Medical School at the University of Valencia in 1992 and from 1993 to 1997, did his Residency in Obstetrics and Gynaecology at Hospital La Fe, Valencia. Dr. Bosch trained in Human Reproduction at the Hospital of the University of Pennsylvania in 1997; and in 1999, he completed his doctoral thesis on the influence of LH on oocyte quality, with “cum laude” qualification, at the University of Valencia. In January 2000, Ernesto joined the team at the Human Reproduction Unit of the Instituto Valenciano de Infertilidad (IVI) in Valencia; and in 2008 he obtained Master’s Degree in Research on Health Sciences, by the Autonomous University if Barcelona.

Dr. Bosch has published 52 papers in peer reviewed journals and written more than 50 book chapters in the field of IVF; has given over 200 lectures at international meetings around the world. He belongs to the Editorial Board of Fertility and Sterility, and Reproductive Biomedicine Online and is a regular reviewer for Human Reproduction, and Reproductive Biology and Endocrinology among others. He belonged to the Special Interest Group on Reproductive Endocrinology of the Spanish Fertility Society, and currently to the Special Interest Group on Reproductive Endocrinology of ESHRE. He was the National Representative of the Spanish clinicians at the ESHRE committee between 2014 and 2016. He received the Scientific Program Prize Paper Award at the 2008 Annual Meeting of the American Society for Reproductive Medicine. In May 2010, Dr. Bosch was appointed Medical Director of the Human Reproduction Unit of the Instituto Valenciano de Infertilidad in Valencia.

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Education and Training

M.D.. University of Valencia Medical School 1992
General Physician. Hospital Clínico Universitario. Valencia 1993
Residency Obstetrics and Gynaecology. Hospital Universitario La Fe. Valencia 1994-1997
Doctoral Courses. University of Valencia 1995-1996
Clinical Fellowship on Human Reproduction at The Hospital of the University of Pennsylvania. Philadelphia. USA 1997
Staff at the Human Reproduction unit. Hospital Universitario La Fe. Valencia 1998
Statistical Methods in Health Sciences. (300 hours). Universidad Autónoma de Barcelona 1997-1998
Postdoctoral Research under the direction of Prof. Alberto Romeu from Hospital Universitario La Fe of Valencia, and Prof. Luis Blasco from The Hospital of The University of Pennsylvania, Philadelphia, USA 1999
1999-2000: Multivariate Analysis (240 hours). Universidad Autónoma de Barcelona 1999-2000
European Diplomat in Gynecological Endoscopy. Universidad de Alcalá de Henares, and University of Clermont-Ferrand
2008: Master on Design of Research projects. Universidad Autónoma de Barcelona		 2008

Honors and recognition

ASRM General Program Paper Prize. 2008

Publications


  • Individualized versus conventional ovarian stimulation for in vitro fertilization: a multicenter, randomized, controlled, assessor-blinded, phase 3 non inferiority trial.
    Nyboe Andersen A, Nelson SM, Fauser BC, García-Velasco JA, Klein BM, Arce JC; ESTHER-1 study group.
    Fertil Steril, 107(2):387-396, 2017.

  • Regimen of ovarian stimulation affects oocyte and therefore embryo quality.
    Bosch E, Labarta E, Kolibianakis E, Rosen M, Meldrum D.
    Fertil Steril. 2016.

  • The necessity to define the sub-optimal responders.
    Garcia-Velasco JA, Bosch E.
    Hum Reprod, 30(12):29-58, 2015.

  • Comprehensive carrier genetic test using next-generation deoxyribonucleic acid sequencing in infertile couples wishing to conceive through assisted reproductive technology.
    Martin J, Asan, Yi Y, Alberola T, Rodríguez-Iglesias B, Jiménez-Almazán J, Li Q, Du H, Alama P, Ruiz A, Bosch E, Garrido N, Simon C.
    Fertil Steril, 104(5):1286-93, 2015.

  • The time to prevent mendelian genetic diseases from donated or own gametes has come.
    Garrido N, Bosch E, Alamá P, Ruiz A.
    Fertil Steril, 104(4):833-5, 2015.

 

  • Follicular and endocrine dose-responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049).
    Bosch E, Nyboe Andersen A, Barri P, García-Velasco JA, de Sutter P,Fernández-Sánchez M, Visnova H, Klein BM, Mannaerts B, Arce JC. Clin Endocrinol, 2015.

  • High responders and patients with a good prognosis are not immune to the negative impact on live birth rate of elevated P on the day of triggering.
    Bosch E.
    Fertil Steril, 103(6):1423, 2015.

  • Prospective study into the value of the automated Elecsys antimüllerian hormone assay for the assessment of the ovarian growing follicle pool.
    Anderson RA, Anckaert E, Bosch E, Dewailly D, Dunlop CE, Fehr D, Nardo L, Smitz J, Tremellen K, Denk B, Geistanger A, Hund M.
    Fertil Steril, 103(4):1074-1080, 2015.

  • Reply: Endometrial scratching for women with repeated implantation failure.
    Simón C, Bosch E, Bellver J.
    Hum Reprod, 2014.

  • Ovarian response to recombinant human follicle-stimulating hormone: a randomized, anti-Müllerian hormone-stratified, dose-response trial in women undergoing in vitro fertilization/intracytoplasmic sperm injection.
    Arce JC, Nyboe Andersen A, Fernández-Sánchez M, Visnova H, Bosch E, García-Velasco JA, Barri P, de Sutter P, Klein BM, Fauser BC.
    Fertil Steril, 2014.

  • High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study.
    Requena A, Cruz M, Bosch E, Meseguer M, García-Velasco JA.
    Reprod Biol Endocrinol, 12:69, 2014.

  • Impact of ovarian stimulation with gonadotrophins on embryo aneuploidy.
    Labarta E, Bosch E, Pellicer A.
    Hum Reprod Update, 2014.

  • Comment on 'Recombinant LH supplementation to a standard GnRH antagonist protocol in women of 35 years old or older undergoing IVF/ICSI: a randomized controlled multicentre study'.
    Bosch E.
    Hum Reprod, 29(3):636-7, 2014.

  • Does progesterone elevation compromise pregnancy rates in high responders? Insufficient evidence to draw a conclusion.
    Bosch E.
    Fertil Steril, 101(1):e3-4, 2014.

  • Controlled ovarian hyperstimulation regimens: a review of the available evidence for clinical practice. Produced on behalf of the BFS Policy and Practice Committee.
    Nardo LG, Bosch E, Lambalk CB, Gelbaya TA.
    Hum Fertil,16(3):144-50, 2013.

  • Treatment of luteal phase defects in assisted reproduction.
    Muñoz E, Taboas E, Portela S, Aguilar J, Fernandez I, Muñoz L, Bosch E.
    Curr Drug Targets,14(8):832-42, 2013.

  • Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials.
    Rubio C, Bellver J, Rodrigo L, Bosch E, Mercader A, Vidal C, De Los Santos MJ, Giles J, Labarta E, Domingo J, Crespo J, Remohí J, Pellicer A, Simón C.
    Fertil Steril, 99(5):1400-7, 2013.

  • Personalized prediction of first-cycle in vitro fertilization success.
    Choi B, Bosch E, Lannon BM, Leveille MC, Wong WH, Leader A, Pellicer A, Penzias AS, Yao MW.
    Fertil Steril, 2013.

  • The follicular hormonal profile in low-responder patients undergoing unstimulated cycles: is it hypoandrogenic?
    de los Santos MJ, García-Laez V, Beltrán D, Labarta E, Zuzuarregui JL, Alamá P, Gámiz P, Crespo J, Bosch E, Pellicer A.
    Hum Reprod, 28(1):224-9, 2013.

  • Moderate ovarian stimulation does not increase the incidence of human embryo chromosomal abnormalities in in vitro fertilization cycles.
    Labarta E, Bosch E, Alamá P, Rubio C, Rodrigo L, Pellicer A.
    J Clin Endocrinol Metab, 97(10):E1987-94, 2012

  • Can we skip weekends in GnRH antagonist cycles without compromising the final outcome?
    Bosch E.
    Fertil Steril, 97(6):1299-300, 2012.

  • The role of LH in ovarian stimulation.
    Munoz E, Bosch E, Fernandez I, Portela S, Ortiz G, Remohi J, Pellicer A.
    Curr Pharm Biotechnol, 13(3):409-16, 2012.

  • Conventional ovarian stimulation no longer exists: welcome to the age of individualized ovarian stimulation.
    Nardo LG, Fleming R, Howles CM, Bosch E, Hamamah S, Ubaldi FM, Hugues JN, Balen AH, Nelson SM.
    Reprod Biomed Online, 23(2):141-8, 2011.

  • Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis.
    Labarta E, Martínez-Conejero JA, Alamá P, Horcajadas JA, Pellicer A, Simón C, Bosch E.
    Hum Reprod, 26(7):1813-25, 2011.

  • Aromatase inhibitors in stimulated IVF cycles.
    Papanikolaou EG, Polyzos NP, Humaidan P, Pados G, Bosch E, Tournaye H, Tarlatzis B.
    Reprod Biol Endocrinol, 21;9:85, 2011.

  • Individualised controlled ovarian stimulation (iCOS): maximising success rates for assisted reproductive technology patients.
    Bosch E, Ezcurra D.
    Reprod Biol Endocrinol, 9:82, 2011.

  • Impact luteinizing hormone administration on gonadotropin-releasing hormone antagonist cycles: an age-adjusted analysis.
    Bosch E, Labarta E, Crespo J, Simón C, Remohí J, Pellicer A.
    Fertil Steril, 1;95(3):1031-6, 2011.

  • The use of prediction models of spontaneous pregnancy in in vitro fertilization units reveals differences between the expected results of public and private clinics in Spain.
    Gabbanini M, Privitera L, Monzó A, Higueras G, Fuster S, Garrido N, Bosch E, Pellicer A.
    Fertil Steril, 94(6):2376-8, 2010.

  • GnRH agonist administration at the time of implantation does not improve pregnancy outcome in intrauterine insemination cycles: a randomized controlled trial.
    Bellver J, Labarta E, Bosch E, Melo MA, Vidal C, Remohí J, Pellicer A. Fertil Steril,;94(3):1065-71, 2010.

  • Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles.
    Bosch E, Labarta E, Crespo J, Simón C, Remohí J, Jenkins J, Pellicer A.
    Hum Reprod, 25(8):2092-100, 2010.

  • Recombinant human follicular stimulating hormone and recombinant human luteinizing hormone in a 2:1 ratio combination. Pharmacological characteristics and clinical applications.
    Bosch E.
    Expert Opin Biol Ther, 10(6):1001-9, 2010

  • Highly purified hMG versus recombinant FSH in ovarian hyperstimulation with GnRH antagonists—a randomized study.
    Bosch E, Vidal C, Labarta E, Simon C, Remohi J, Pellicer A.
    Hum Reprod, 23(10):2346-51, 2008.

  • Clinical factors affecting endometrial receptiveness in oocyte donation cycles.
    Soares SR, Velasco JA, Fernandez M, Bosch E, Remohí J, Pellicer A, Simón C.
    Fertil Steril, 89(3):491, 2008.

  • Comment on: is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? A systematic review and meta-analysis.
    Bosch E.
    By Venetis et al (2007). Hum Reprod Update. Mar-Apr;14(2):194-5, 2008.

  • Obesity and poor reproductive outcome: the potential role of the endometrium.
    Bellver J, Melo MA, Bosch E, Serra V, Remohí J, Pellicer A.
    Fertil Steril, 88(2):446-51, 2007.

  • Effect of a sharp serum oestradiol fall before HCG administration during ovarian stimulation in donors.
    Cobo A, Bosch E, Alvarez C, de los Santos MJ, Pellicer A, Remohí J. Reprod Biomed Online, 15(2):169-74, 2007.

  • Delaying the initiation of progesterone supplementation until the day of fertilization does not compromise cycle outcome in patients receiving donated oocytes: a randomized study.
    Escribá MJ, Bellver J, Bosch E, Sánchez M, Pellicer A, Remohí J.
    Fertil Steril,;86(1):92-7, 2006.

  • The significance of premature luteinization in an oocyte-donation programme.
    Melo MA, Meseguer M, Garrido N, Bosch E, Pellicer A, Remohí J.
    Hum Reprod, 21(6):1503-7, 2006

  • Similar endometrial development in oocyte donors treated with either high- or standard-dose GnRH antagonist compared to treatment with a GnRH agonist or in natural cycles.
    Adams S, Riesewijk A, Mannaerts B, Pellicer A.
    Hum Reprod, 20(12):3318-27, 2005.

  • Evidence-based medicine is gaining momentum.
    Bellver J, Bosch E, Remohí J, Pellicer A.
    Fertil Steril, 84(5):1555-6; author reply 1556-7, 2005.

  • Serum l uteinizing hormone in patients undergoing ovarian stimulation withgonadotropin-releasing hormone antagonists and recombinant follicle-stimulating hormone and its relationship with cycle outcome.
    Bosch E, Escudero E, Crespo J, Simón C, Remohí J, Pellicer A.
    Fertil Steril, 84(5):1529-32, 2005.

  • Age and uterine receptiveness: predicting the outcome of oocyte donation cycles.
    Soares SR, Troncoso C, Bosch E, Serra V, Simón C, Remohí J, Pellicer A.
    J Clin Endocrinol Metab, 90(7):4399-404, 2005.

  • Evidence-based investigations and treatments of recurrent pregnancy loss.
    Christiansen OB, Nybo Andersen AM, Bosch E, Daya S, Delves PJ, Hviid TV, Kutteh WH, Laird SM, Li TC, van der Ven K.
    Fertil Steril 83(4):821-39, 2005.

  • BMI--the fragility of fertility.
    Bellver J, Bosch E, Pellicer A.
    Fertil Steril, 81(3):727; author reply 727-8, 2004.

  • Comparison of two different starting multiple dose gonadotropin-releasing hormone antagonist protocols in a selected group of in vitro fertilization-embryo transfer patients.
    Escudero E, Bosch E, Crespo J, Simón C, Remohí J, Pellicer A.
    Fertil Steril, 81(3):562-6, 2004

  • Premature luteinization during gonadotropin-releasing hormone antagonist cycles and its relationship with in vitro fertilization outcome.
    Bosch E, Valencia I, Escudero E, Crespo J, Simón C, Remohí J, Pellicer A.
    Fertil Steril, 80(6):1444-9, 2003.

  • Intravenous albumin does not prevent moderate-severe ovarian hyperstimulation syndrome in high-risk IVF patients: a randomized controlled study.
    Bellver J, Muñoz EA, Ballesteros A, Soares SR, Bosch E, Simón C, Pellicer A, Remohí J.
    Hum Reprod, 18(11):2283-8, 2003.

  • Obesity and the risk of spontaneous abortion after oocyte donation.
    Bellver J, Rossal LP, Bosch E, Zúñiga A, Corona JT, Meléndez F, Gómez E, Simón C, Remohí J, Pellicer A.
    Fertil Steril, 79(5):1136-40, 2003.

  • The origin of biochemical pregnancies: lessons learned from preimplantation genetic diagnosis.
    Troncoso C, Bosch E, Rubio C, Remohí J, Simón C, Pellicer A.
    Fertil Steril, 79(2):449-50, 2003.

  • Endometrial quality in infertile women with endometriosis.
    Pellicer A, Navarro J, Bosch E, Garrido N, Garcia-Velasco JA, Remohí J, Simón C.
    Ann N Y Acad Sci, 943:122-30, 2001.

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Clinical trial to try to diagnose pregnancy as soon as four days after embryo transfer
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