Alberto Vaiarelli

Biography

Alberto Vaiarelli is gynecologist Fertility Specialist and Medical Scientific Coordinator of Genera Roma. He is a member of executive board of Italian Society of Fertility, Sterility and Reproductive Medicine (SIFES-MR),…

He graduated from University of Messina and he attended a specialisation in Obstetrics and Gynaecology with subspecialist in Reproductive Medicine at the same University cum laude.

During his training he completed i) Clinical Clerkship at Department of Obstetrics and Gynecology, Main Center Hospital, School of Medicine of Virginia Commonwealth University, Richmond (USA); ii) Research Fellow at Yale School of Medicine, Yale University; iii) Clinical Fellow at Centrum voor Reproductieve Geneeskunde (CRG or Centre for Reproductive Medicine) Universitair Ziekenhuis Brussel.

He obtained a Ph.D. and Post-doctor Fellow in Reproductive Endocrinology at University of Messina.

He got two Master the first in Andrology and Reproductive Medicine at University of Pavia; the second in Assisted Reproductive Technology at University of Urbino.

Recognition of the professional qualification of Medical Doctor, Specialist in Gynaecology and Obstetrics with Physiopathology of Human Reproduction in Belgium by “Le Ministre de la Santè publique” (INAMI:1-99426-06-340) and in Spain by Ministerio De Sanidad Servicios Sociales e Igualdad.

He is an active member of studies with National or International collaborations on various topics related to Reproductive Medicine (DuoStim, Management of Poor prognosis patients, Impact of male factors during IVF journey….)

He was a Medical Advisor for different providers involved in Reproductive Medicine training for healthcare professionals (Exemed Excellence in Medical Education, Scientific Seminar Foundation, FertySchool by Genera Education program)

He is author and co-authors of more than 81 original research papers and reviews published on peer-reviewed journals (indexed in Pubmed with more than 2300 citations and an h-index of 28 is ISI web of Science) and authored many chapters on national and international textbooks.

He was a member of editorial board of Journal of Assisted Reproduction and Genetics (JARG) and Frontiers in Endocrinology and he is Reviewer of many journals in the field of Reproductive Medicine

He is adjunct professor in different postgraduate options (Specialization course, Master’s and Doctoral degree) at different University (Pavia, Roma, Padova, Urbino, Bologna, Messina)

In 2018 he achieved the National Certification as Associate Professor and in 2021 as Full Professor in OB/GYN 06/H1 by the Ministry of Education, University and Research.

He was actively involved in the Medical Board of GeneraLife group, a network of >30 IVF clinics in 5 different countries in Europe, in drafting Internal Guidelines and in planning the scientific activity.

He is internationally recognized as an expert in Reproductive Medicine participating as a speaker and as a member of the scientific committee during several National and International Conference.

His scientific work is primarily focused on the management of poor prognosis patients and on the improvement of efficacy and efficiency in ART.

Education and Training

B.Sc. Medicine and Surgery	University of Messina (IT)
Clinical Clerkship, OB/Gyn	Virginia Commonwealth University-Richmond (USA)
Specialization in Obstetrics and Gynaecology	University of Messina (IT)
Ph.D Reproductive Endocrinology	University of Messina (IT)
Research Fellowship in Reproductive Endocrinology and Infertility	Yale University (USA)
Post-doctoral Researcher	University of Messina (IT)
Clinical Fellowship	UZ Brussel Fertility Clinic (CRG)
M.Sc. Andrology and Reproductive Medicine	University of Padova (IT)
M.Sc. Assisted Reproductive Technology	University of Urbino (IT)

Honors and recognition

1st prize for best oral communication at the National Congress of Reproductive Medicine, CECOS, SIFES-MR with the following work: "Progesterone at trigger and probability of pregnancy in relation to the number of oocytes retrieved: analysis of 5258 cycles"	2013
Robert G. Edwards Prize Paper Award 2015 candidate for the best article published on RBMOnline with the following work: “How to define , diagnose and treat poor responders? Responses from a worldwide survey of IVF clinics.” Reprod Biomed Online. 2015 Jun;30(6):581-92.	2015
Top five most read articles in Human Reproduction: 2017. Thyroid autoimmunity, hypothyroidism and ovarian reserve: a cross-sectional study of 5000 women based on age-specific AMH values. Hum Reprod. 2015 Jul;30(7):1690-6.	2015
1st prize for best abstract at the 3rd Global Congress of Ian Donalds Schools with the following work: "Double Stimulation in a single menstrual cycle increases the number of oocytes collected in poor prognosis patients undergoing IVF treatment: prospective study with historical control"	2015
2nd Prize at the National Congress SIFES and MR (Italian Society of Fertility and Sterility and Reproductive Medicine) for best oral communication “Metaphase II (MII) oocytes obtained after hormonal stimulation in the luteal phase have the same competence as the MII oocytes obtained after stimulation in the follicular phase. Results of a prospective multicenter study"	2017
1st Prize during the #LH2020 Awards International Congress for best abstract entitled “R-FSH or HMG during ovarian stimulation resulted in similar mean euploid blastocyst rates per cohort of inseminated oocytes: an observational study on 961 patients”	2020

Publications

Clinical and laboratory key performance indicators in IVF: A consensus between the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR) and the Italian Society of Embryology, Reproduction and Research (SIERR).
Vaiarelli A, Zaca C, Spadoni V, Cimadomo D, Conforti A, Alviggi C, Palermo R, Bulletti C, De Santis L, Pisaturo V, Vigiliano V, Scaravelli G, Ubaldi FM, Borini A

J Assist Reprod Genet. 2023 Apr 24. doi: 10.1007/s10815-023-02792-1. Online ahead of print.. 2023 doi:

Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis.
Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, Poli M, Hynes J, Gemmell L, Vaiarelli A, Alviggi C, Ubaldi FM, Capalbo A

Hum Reprod Update. 2023 May 16:dmad010. doi: 10.1093/humupd/dmad010. Online ahead of print.. 2023 doi:

Low-quality evidence from a randomized controlled trial due to an inappropriate IVF setting to challenge Dual Stimulation strategy.
Ubaldi FM, Vaiarelli A, Cimadomo D, Cerrillo M, Rienzi L, Garcia-Velasco JA

Hum Reprod. 2023 Jun 5:dead108. doi: 10.1093/humrep/dead108. Online ahead of print.. 2023 doi:

How should the best human embryo in vitro be? Current and future challenges for embryo selection.
Cimadomo D, Innocenti F, Taggi M, Saturno G, Campitiello MR, Guido M, Vaiarelli A, Ubaldi FM, Rienzi L

Minerva Obstet Gynecol. 2023 Jun 16. doi: 10.23736/S2724-606X.23.05296-X. Online ahead of print.. 2023 doi:

Cryostorage management of reproductive cells and tissues in ART: status, needs, opportunities, and potential new challenges
Canosa S, Maggiulli R, Cimadomo D, Innocenti F, Fabozzi G, Gennarelli G, Revelli A, Bongioanni F, Vaiarelli A, Ubaldi FM, Rienzi L, Palmer GA, Nijs M

Reproductive BioMedicine Online Available online 22 June 202 In press. 2023 doi:

DuoStim reduces time to pregnancy, minimizes treatment discontinuation, and is potentially cost-effective.
Garcia-Velasco JA, Cimadomo D, Cerrillo M, Vaiarelli A, Ubaldi FM

Hum Reprod. 2023 Jun 23:dead113. doi: 10.1093/humrep/dead113. Online ahead of print.. 2023 doi:

Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: implications for fertility.
Fiorentino G, Cimadomo D, Innocenti F, Soscia D, Vaiarelli A, Ubaldi FM, Gennarelli G, Garagna S, Rienzi L, Zuccotti M

Hum Reprod Update. 2023 Jan 5;29(1):1-23. doi: 10.1093/humupd/dmac031.. 2023 doi:

Male factor infertility and assisted reproductive technologies: indications, minimum access criteria and outcomes.
Mazzilli R, Rucci C, Vaiarelli A, Cimadomo D, Ubaldi FM, Foresta C, Ferlin AJ

Endocrinol Invest. 2023 Jan 12. doi: 10.1007/s40618-022-02000-4. Online ahead of print.. 2023 doi:

Towards Automation in IVF: Pre-Clinical Validation of a Deep Learning-Based Embryo Grading System during PGT-A Cycles.
Cimadomo D, Chiappetta V, Innocenti F, Saturno G, Taggi M, Marconetto A, Casciani V, Albricci L, Maggiulli R, Coticchio G, Ahlström A, Berntsen J, Larman M, Borini A, Vaiarelli A, Ubaldi FM, Rienzi L

J Clin Med. 2023 Feb 23;12(5):1806. doi: 10.3390/jcm12051806.. 2023 doi:

Double stimulation for the management of poor-prognosis patients: where are we going?
Petrone P, Vaiarelli A, Blockeel C

Curr Opin Obstet Gynecol. 2023 Mar 7. doi: 10.1097/GCO.0000000000000869. Online ahead of print.. 2023 doi:

Clinical and laboratory key performance indicators in IVF: A consensus between the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR) and the Italian Society of Embryology, Reproduction and Research (SIERR).
Vaiarelli A, Zacà C, Spadoni V, Cimadomo D, Conforti A, Alviggi C, Palermo R, Bulletti C, De Santis L, Pisaturo V, Vigiliano V, Scaravelli G, Ubaldi FM, Borini A

J Assist Reprod Genet. 2023 Apr 24. doi: 10.1007/s10815-023-02792-1. Online ahead of print.. 2023 doi:

Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis.
Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, Poli M, Hynes J, Gemmell L, Vaiarelli A, Alviggi C, Ubaldi FM, Capalbo A

Hum Reprod Update. 2023 May 16:dmad010. doi: 10.1093/humupd/dmad010. Online ahead of print.. 2023 doi:

Low-quality evidence from a randomized controlled trial due to an inappropriate IVF setting to challenge Dual Stimulation strategy.
Ubaldi FM, Vaiarelli A, Cimadomo D, Cerrillo M, Rienzi L, Garcia-Velasco JA

Hum Reprod. 2023 Jun 5:dead108. doi: 10.1093/humrep/dead108. Online ahead of print.. 2023 doi:

How should the best human embryo in vitro be? Current and future challenges for embryo selection.
Cimadomo D, Innocenti F, Taggi M, Saturno G, Campitiello MR, Guido M, Vaiarelli A, Ubaldi FM, Rienzi L

Minerva Obstet Gynecol. 2023 Jun 16. doi: 10.23736/S2724-606X.23.05296-X. Online ahead of print.. 2023 doi:

Cryostorage management of reproductive cells and tissues in ART: status, needs, opportunities, and potential new challenges
Canosa S, Maggiulli R, Cimadomo D, Innocenti F, Fabozzi G, Gennarelli G, Revelli A, Bongioanni F, Vaiarelli A, Ubaldi FM, Rienzi L, Palmer GA, Nijs M

Reproductive BioMedicine Online Available online 22 June 202 In press. 2022 doi:

Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation.
Fabozzi G, Verdone G, Allori M, Cimadomo D, Tatone C, Stuppia L, Franzago M, Ubaldi N, Vaiarelli A, Ubaldi FM, Rienzi L, Gennarelli G

Nutrients. 2022 May 3;14(9):1918. doi: 10.3390/nu14091918.. 2022 doi:

How slow is too slow? A comprehensive portrait of Day 7 blastocysts and their clinical value standardized through artificial intelligence.
Cimadomo D, Soscia D, Casciani V, Innocenti F, Trio S, Chiappetta V, Albricci L, Maggiulli R, Erlich I, Ben-Meir A, Har-Vardi I, Vaiarelli A, Ubaldi FM, Rienzi L

Hum Reprod. 2022 May 30;37(6):1134-1147. doi: 10.1093/humrep/deac080. . 2022 doi:

Neither rationale nor scientific evidence exist to support that double stimulation is potentially unsafe.
Casarini L, Vaiarelli A, Cimadomo D, Santi D, Simoni M, Garcìa-Velasco JA, Alviggi C, La Marca A, Rienzi L, Ubaldi FM

Hum Reprod. 2022 Jul 30;37(8):1949-1950. doi: 10.1093/humrep/deac064.. 2022 doi:

Second stimulation in the same ovarian cycle: an option to fully-personalize the treatment in poor prognosis patients undergoing PGT-A.
Vaiarelli A, Cimadomo D, Gennarelli G, Guido M, Alviggi C, Conforti A, Livi C, Revelli A, Colamaria S, Argento C, Giuliani M, De Angelis C, Matteo M, Canosa S, D'Alfonso A, Cimadomo V, Rienzi L, Ubaldi FM

J Assist Reprod Genet. 2022 Mar;39(3):663-673. doi: 10.1007/s10815-022-02409-z. Epub 2022 Feb 7.. 2022 doi:

The effect of extended cryo-storage following vitrification on embryo competence: a systematic review and meta-analysis.
Canosa S, Cimadomo D, Conforti A, Maggiulli R, Giancani A, Tallarita A, Golia F, Fabozzi G, Vaiarelli A, Gennarelli G, Revelli A, Bongioanni F, Alviggi C, Ubaldi FM, Rienzi L, SIERR

J Assist Reprod Genet. 2022 Apr;39(4):873-882. doi: 10.1007/s10815-022-02405-3. Epub 2022 Feb 4.. 2022 doi:

Clinical, obstetric and perinatal outcomes after vitrified-warmed euploid blastocyst transfer are independent of cryo-storage duration.
Cimadomo D, Fabozzi G, Dovere L, Maggiulli R, Albricci L, Innocenti F, Soscia D, Giancani A, Vaiarelli A, Guido M, Ubaldi FM, Rienzi L

Reprod Biomed Online. 2022 Feb;44(2):221-227. doi: 10.1016/j.rbmo.2021.09.027. Epub 2021 Oct 8.. 2022 doi:

Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial.
Capalbo A, Poli M, Rienzi L, Girardi L, Patassini C, Fabiani M, Cimadomo D, Benini F, Farcomeni A, Cuzzi J, Rubio C, Albani E, Sacchi L, Vaiarelli A, Figliuzzi M, Findikli N, Coban O, Boynukalin FK, Vogel I, Hoffmann E, Livi C, Levi-Setti PE, Ubaldi FM, Simón C

Am J Hum Genet. 2021 Dec 2;108(12):2238-2247. doi: 10.1016/j.ajhg.2021.11.002. Epub 2021 Nov 18.. 2021 doi:

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives.
Maggiulli R, Vaiarelli A, Cimadomo D, Giancani A, Tacconi L, Fabozzi G, Ubaldi FM, Rienzi L

J Vis Exp. 2021 Sep 16;(175). doi: 10.3791/61963.. 2021 doi:

Measuring success in IVF is a complex multidisciplinary task: time for a consensus?
Rienzi L, Cimadomo D, Vaiarelli A, Gennarelli G, Holte J, Livi C, Aura Masip M, Uher P, Fabozzi G, Ubaldi FM

Reprod Biomed Online. 2021 Nov;43(5):775-778. doi: 10.1016/j.rbmo.2021.08.012. Epub 2021 Aug 20. . 2021 doi:

Maternal body mass index associates with blastocyst euploidy and live birth rates: the tip of an iceberg?
Fabozzi G, Cimadomo D, Allori M, Vaiarelli A, Colamaria S, Argento C, Amendola MG, Innocenti F, Soscia D, Maggiulli R, Mazzilli R, Ubaldi N, Iussig B, Marchetti M, Rienzi L, Ubaldi FM

Reprod Biomed Online. 2021 Oct;43(4):645-654. doi: 10.1016/j.rbmo.2021.07.006. Epub 2021 Jul 22.. 2021 doi:

Severe male factor in in vitro fertilization: definition, prevalence, and treatment. An update.
Mazzilli R, Vaiarelli A, Dovere L, Cimadomo D, Ubaldi N, Ferrero S, Rienzi L, Lombardo F, Lenzi A, Tournaye H, Ubaldi FM

Asian J Androl. 2022 Mar-Apr;24(2):125-134. doi: 10.4103/aja.aja_53_21.. 2021 doi:

Clinical validity and utility of preconception expanded carrier screening for the management of reproductive genetic risk in IVF and general population.
Capalbo A, Fabiani M, Caroselli S, Poli M, Girardi L, Patassini C, Favero F, Cimadomo D, Vaiarelli A, Simon C, Rienzi LF, Ubaldi FM

Hum Reprod. 2021 Jun 18;36(7):2050-2061. doi: 10.1093/humrep/deab087. 2021 doi:

Is a randomized controlled design sufficient for a trial to be valuable?
Ubaldi FM, Cimadomo D, Vaiarelli A, Rienzi L

Hum Reprod. 2021 Jul 19;36(8):2416-2417. doi: 10.1093/humrep/deab114.. 2021 doi:

Oocyte competence is independent of the ovulation trigger adopted: a large observational study in a setting that entails vitrified-warmed single euploid blastocyst transfer.
Cimadomo D, Vaiarelli A, Petriglia C, Fabozzi G, Ferrero S, Schimberni M, Argento C, Colamaria S, Giuliani M, Ubaldi N, Rienzi L, Ubaldi FM

J Assist Reprod Genet. 2021 Jun;38(6):1419-1427. doi: 10.1007/s10815-021-02124-1. Epub 2021 Mar 4.. 2021 doi:

Reply: 'Second stimulation in the same ovarian cycle', probably a terminology more appropriate than 'luteal phase stimulation' in the DuoStim protocol.
Vaiarelli A, Cimadomo D, Rienzi L, Ubaldi FM

Hum Reprod. 2021 May 17;36(6):1723-1724. doi: 10.1093/humrep/deab018.. 2021 doi:

Leave the past behind: women's reproductive history shows no association with blastocysts' euploidy and limited association with live birth rates after euploid embryo transfers.
Cimadomo D, Capalbo A, Dovere L, Tacconi L, Soscia D, Giancani A, Scepi E, Maggiulli R, Vaiarelli A, Rienzi L, Ubaldi FM

Hum Reprod. 2021 Mar 18;36(4):929-940. doi: 10.1093/humrep/deab014.. 2021 doi:

The Impact of Unbalanced Maternal Nutritional Intakes on Oocyte Mitochondrial Activity: Implications for Reproductive Function.
Fabozzi G, Iussig B, Cimadomo D, Vaiarelli A, Maggiulli R, Ubaldi N, Ubaldi FM, Rienzi L

Antioxidants (Basel). 2021 Jan 11;10(1):91. doi: 10.3390/antiox10010091.. 2021 doi:

Metaphase-II oocyte competence is unlinked to the gonadotrophins used for ovarian stimulation: a matched case-control study in women of advanced maternal age.
Vaiarelli A, Cimadomo D, Scarafia C, Innocenti F, Amendola MG, Fabozzi G, Casarini L, Conforti A, Alviggi C, Gennarelli G, Benedetto C, Guido M, Borini A, Rienzi L, Ubaldi FM

J Assist Reprod Genet. 2023 Jan;40(1):169-177. doi: 10.1007/s10815-022-02684-w. Epub 2022 Dec 31.. 2023 doi:

Recombinant human luteinizing hormone co-treatment in ovarian stimulation for assisted reproductive technology in women of advanced reproductive age: a systematic review and meta-analysis of randomized controlled trials.
Conforti A, Esteves SC, Humaidan P, Longobardi S, D'Hooghe T, Orvieto R, Vaiarelli A, Cimadomo D, Rienzi L, Ubaldi FM, Zullo F, Alviggi C

Reprod Biol Endocrinol. 2021 Jun 21;19(1):91. doi: 10.1186/s12958-021-00759-4.. 2021 doi:

Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines.
Esteves SC, Conforti A, Sunkara SK, Carbone L, Picarelli S, Vaiarelli A, Cimadomo D, Rienzi L, Ubaldi FM, Zullo F, Andersen CY, Orvieto R, Humaidan P, Alviggi C

Front Endocrinol (Lausanne). 2021 Mar 19;12:587051. doi: 10.3389/fendo.2021.587051. eCollection 2021.. 2021 doi:

Endometriosis shows no impact on the euploid blastocyst rate per cohort of inseminated metaphase-II oocytes: A case-control study.
Vaiarelli A, Venturella R, Cimadomo D, Conforti A, Pedri S, Bitonti G, Iussig B, Gentile C, Alviggi E, Santopaolo S, Zullo F, Rienzi L, Ubaldi FM

Eur J Obstet Gynecol Reprod Biol. 2021 Jan;256:205-210. doi: 10.1016/j.ejogrb.2020.11.024. Epub 2020 Nov 11.. 2021 doi:

Perinatal and obstetric outcomes in singleton pregnancies following fresh versus cryopreserved blastocyst transfer: a meta-analysis.
Conforti A, Picarelli S, Carbone L, La Marca A, Venturella R, Vaiarelli A, Cimadomo D, Zullo F, Rienzi L, Ubaldi FM, Alviggi C

Reprod Biomed Online. 2021 Feb;42(2):401-412. doi: 10.1016/j.rbmo.2020.09.029. Epub 2020 Oct 5.. 2021 doi:

The euploid blastocysts obtained after luteal phase stimulation show the same clinical, obstetric and perinatal outcomes as follicular phase stimulation-derived ones: a multicenter study.
Vaiarelli A, Cimadomo D, Alviggi E, Sansone A, Trabucco E, Dusi L, Buffo L, Barnocchi N, Fiorini F, Colamaria S, Giuliani M, Argento C, Rienzi L, Ubaldi FM

Hum Reprod. 2020 Nov 1;35(11):2598-2608. doi: 10.1093/humrep/deaa203.. 2020 doi:

Which key performance indicators are most effective in evaluating and managing an in vitro fertilization laboratory?
Fabozzi G, Cimadomo D, Maggiulli R, Vaiarelli A, Ubaldi FM, Rienzi L

Fertil Steril. 2020 Jul;114(1):9-15. doi: 10.1016/j.fertnstert.2020.04.054. Epub 2020 Jun 9. . 2020 doi:

COVID-19 and assisted reproductive technology services: repercussions for patients and proposal for individualized clinical management.
Alviggi C, Esteves SC, Orvieto R, Conforti A, La Marca A, Fischer R, Andersen CY, Bühler K, Sunkara SK, Polyzos NP, Strina I, Carbone L, Bento FC, Galliano D, Yarali H, Vuong LN, Grynberg M, Drakopoulos P, Xavier P, Llacer J, Neuspiller F, Horton M, Roque M, Papanikolaou E, Banker M, Dahan MH, Foong S, Tournaye H, Blockeel C, Vaiarelli A, Humaidan P, Ubaldi FM, POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) group

Reprod Biol Endocrinol. 2020 May 13;18(1):45. doi: 10.1186/s12958-020-00605-z.. 2020 doi:

COVID-19 and ART: the view of the Italian Society of Fertility and Sterility and Reproductive Medicine.
Vaiarelli A, Bulletti C, Cimadomo D, Borini A, Alviggi C, Ajossa S, Anserini P, Gennarelli G, Guido M, Levi-Setti PE, Palagiano A, Palermo R, Savasi V, Pellicer A, Rienzi L, Ubaldi FM

Reprod Biomed Online. 2020 Jun;40(6):755-759. doi: 10.1016/j.rbmo.2020.04.003. Epub 2020 Apr 8.. 2020 doi:

DuoStim - a reproducible strategy to obtain more oocytes and competent embryos in a short time-frame aimed at fertility preservation and IVF purposes. A systematic review.
Vaiarelli A, Cimadomo D, Petriglia C, Conforti A, Alviggi C, Ubaldi N, Ledda S, Ferrero S, Rienzi L, Ubaldi FM

Ups J Med Sci. 2020 May;125(2):121-130. doi: 10.1080/03009734.2020.1734694. Epub 2020 Apr 25.. 2020 doi:

Definition of a clinical strategy to enhance the efficacy, efficiency and safety of egg donation cycles with imported vitrified oocytes.
Rienzi L, Cimadomo D, Maggiulli R, Vaiarelli A, Dusi L, Buffo L, Amendola MG, Colamaria S, Giuliani M, Bruno G, Stoppa M, Ubaldi FM

Hum Reprod. 2020 Apr 28;35(4):785-795. doi: 10.1093/humrep/deaa009.. 2020 doi:

Validation of ART Calculator for Predicting the Number of Metaphase II Oocytes Required for Obtaining at Least One Euploid Blastocyst for Transfer in Couples Undergoing in vitro Fertilization/Intracytoplasmic Sperm Injection.
Esteves SC, Yarali H, Ubaldi FM, Carvalho JF, Bento FC, Vaiarelli A, Cimadomo D, Özbek İY, Polat M, Bozdag G, Rienzi L, Alviggi C

Front Endocrinol (Lausanne). 2020 Jan 24;10:917. doi: 10.3389/fendo.2019.00917. eCollection 2019.. 2020 doi:

Luteal phase after conventional stimulation in the same ovarian cycle might improve the management of poor responder patients fulfilling the Bologna criteria: a case series.
Vaiarelli A, Cimadomo D, Conforti A, Schimberni M, Giuliani M, D'Alessandro P, Colamaria S, Alviggi C, Rienzi L, Ubaldi FM

Fertil Steril. 2020 Jan;113(1):121-130. doi: 10.1016/j.fertnstert.2019.09.012. Epub 2019 Dec 16.. 2020 doi:

The POSEIDON Criteria and Its Measure of Success Through the Eyes of Clinicians and Embryologists.
Esteves SC, Alviggi C, Humaidan P, Fischer R, Andersen CY, Conforti A, Bühler K, Sunkara SK, Polyzos NP, Galliano D, Grynberg M, Yarali H, Özbek IY, Roque M, Vuong LN, Banker M, Rienzi L, Vaiarelli A, Cimadomo D, Ubaldi FM

Front Endocrinol (Lausanne). 2019 Nov 20;10:814. doi: 10.3389/fendo.2019.00814. eCollection 2019.. 2019 doi:

Similar miRNomic signatures characterize the follicular fluids collected after follicular and luteal phase stimulations in the same ovarian cycle.
Cimadomo D, Carmelo R, Parrotta EI, Scalise S, Santamaria G, Alviggi E, De Angelis MT, Sarro G, Vaiarelli A, Venturella R, Rienzi L, Zullo F, Ubaldi FM, Cuda G

.J Assist Reprod Genet. 2020 Jan;37(1):149-158. doi: 10.1007/s10815-019-01607-6. Epub 2019 Nov 7. . 2020 doi:

Management of Women With an Unexpected Low Ovarian Response to Gonadotropin.
Conforti A, Esteves SC, Cimadomo D, Vaiarelli A, Di Rella F, Ubaldi FM, Zullo F, De Placido G, Alviggi C

Front Endocrinol (Lausanne). 2019 Jun 27;10:387. doi: 10.3389/fendo.2019.00387. eCollection 2019.. 2019 doi:

Pharmacogenetics of FSH Action in the Female.
Conforti A, Vaiarelli A, Cimadomo D, Bagnulo F, Peluso S, Carbone L, Di Rella F, De Placido G, Ubaldi FM, Huhtaniemi I, Alviggi C

Front Endocrinol (Lausanne). 2019 Jun 26;10:398. doi: 10.3389/fendo.2019.00398. eCollection 2019.. 2019 doi:

Looking past the appearance: a comprehensive description of the clinical contribution of poor-quality blastocysts to increase live birth rates during cycles with aneuploidy testing.
Cimadomo D, Soscia D, Vaiarelli A, Maggiulli R, Capalbo A, Ubaldi FM, Rienzi L

Hum Reprod. 2019 Jul 8;34(7):1206-1214. doi: 10.1093/humrep/dez078.. 2019 doi:

State of the art and emerging drug therapies for female infertility.
Venturella R, Vaiarelli A, Cimadomo D, Pedri S, Lico D, Mazzilli R, Mocciaro R, Rienzi L, Di Carlo C, Ubaldi FM, Zullo F

Gynecol Endocrinol. 2019 Oct;35(10):835-841. doi: 10.1080/09513590.2019.1603289. Epub 2019 Apr 29.. 2019 doi:

Double stimulation in the same ovarian cycle (DuoStim) is an intriguing strategy to improve oocyte yield and the number of competent embryos in a short timeframe.
Vaiarelli A, Cimadomo D, Argento C, Ubaldi N, Trabucco E, Drakopoulos P, Venturella R, Conforti A, Alviggi C, Rienzi L, Ubaldi FM

Minerva Ginecol. 2019 Oct;71(5):372-376. doi: 10.23736/S0026-4784.19.04390-9. Epub 2019 Mar 4.. 2019 doi:

Advanced Maternal Age in IVF: Still a Challenge? The Present and the Future of Its Treatment.
Ubaldi FM, Cimadomo D, Vaiarelli A, Fabozzi G, Venturella R, Maggiulli R, Mazzilli R, Ferrero S, Palagiano A, Rienzi L

Front Endocrinol (Lausanne). 2019 Feb 20;10:94. doi: 10.3389/fendo.2019.00094. eCollection 2019.. 2019 doi:

A brief history of oocyte cryopreservation: Arguments and facts.
Iussig B, Maggiulli R, Fabozzi G, Bertelle S, Vaiarelli A, Cimadomo D, Ubaldi FM, Rienzi L

Acta Obstet Gynecol Scand. 2019 May;98(5):550-558. doi: 10.1111/aogs.13569. Epub 2019 Mar 25.. 2019 doi:

Impact of Maternal Age on Oocyte and Embryo Competence.
Cimadomo D, Fabozzi G, Vaiarelli A, Ubaldi N, Ubaldi FM, Rienzi L

Front Endocrinol (Lausanne). 2018 Jun 29;9:327. doi: 10.3389/fendo.2018.00327. eCollection 2018.. 2018 doi:

Double Stimulation in the Same Ovarian Cycle (DuoStim) to Maximize the Number of Oocytes Retrieved From Poor Prognosis Patients: A Multicenter Experience and SWOT Analysis.
Vaiarelli A, Cimadomo D, Trabucco E, Vallefuoco R, Buffo L, Dusi L, Fiorini F, Barnocchi N, Bulletti FM, Rienzi L, Ubaldi FM

Front Endocrinol (Lausanne). 2018 Jun 14;9:317. doi: 10.3389/fendo.2018.00317. eCollection 2018.. 2018 doi:

Luteal phase anovulatory follicles result in the production of competent oocytes: intra-patient paired case-control study comparing follicular versus luteal phase stimulations in the same ovarian cycle.
Cimadomo D, Vaiarelli A, Colamaria S, Trabucco E, Alviggi C, Venturella R, Alviggi E, Carmelo R, Rienzi L, Ubaldi FM

Hum Reprod. 2018 Aug 1;33(8):1442-1448. doi: 10.1093/humrep/dey217.. 2018 doi:

What is new in the management of poor ovarian response in IVF?
Vaiarelli A, Cimadomo D, Ubaldi N, Rienzi L, Ubaldi FM

Curr Opin Obstet Gynecol. 2018 Jun;30(3):155-162. doi: 10.1097/GCO.0000000000000452.. 2018 doi:

Progesterone for preparation of the endometrium for frozen-thawed blastocyst transfer in vitro fertilization cycles: a prospective study on patients' opinions on a new subcutaneous formulation.
Venturella R, Vaiarelli A, Buffo L, D'alessandro P, Colamaria S, Pedri S, Di Carlo C, Alviggi E, Forte M, Faustini F, Zullo F, Rienzi L, Ubaldi FM

Gynecol Endocrinol. 2018 Sep;34(9):766-771. doi: 10.1080/09513590.2018.1451508. Epub 2018 Mar 16.. 2018 doi:

Effect of the male factor on the clinical outcome of intracytoplasmic sperm injection combined with preimplantation aneuploidy testing: observational longitudinal cohort study of 1,219 consecutive cycles.
Mazzilli R, Cimadomo D, Vaiarelli A, Capalbo A, Dovere L, Alviggi E, Dusi L, Foresta C, Lombardo F, Lenzi A, Tournaye H, Alviggi C, Rienzi L, Ubaldi FM

Fertil Steril. 2017 Dec;108(6):961-972.e3. doi: 10.1016/j.fertnstert.2017.08.033. Epub 2017 Oct 3.. 2017 doi:

Abnormally fertilized oocytes can result in healthy live births: improved genetic technologies for preimplantation genetic testing can be used to rescue viable embryos in in vitro fertilization cycles.
Capalbo A, Treff N, Cimadomo D, Tao X, Ferrero S, Vaiarelli A, Colamaria S, Maggiulli R, Orlando G, Scarica C, Scott R, Ubaldi FM, Rienzi L

Fertil Steril. 2017 Dec;108(6):1007-1015.e3. doi: 10.1016/j.fertnstert.2017.08.004. Epub 2017 Sep 15.. 2017 doi:

A modern approach to the management of candidates for assisted reproductive technology procedures.
Venturella R, Vaiarelli A, Lico D, Ubaldi FM, Zullo F, DI Carlo C

Minerva Ginecol. 2018 Feb;70(1):69-83. doi: 10.23736/S0026-4784.17.04138-7. Epub 2017 Sep 12.. 2018 doi:

Preimplantation genetic diagnosis for aneuploidy testing in women older than 44 years: a multicenter experience.
Ubaldi FM, Cimadomo D, Capalbo A, Vaiarelli A, Buffo L, Trabucco E, Ferrero S, Albani E, Rienzi L, Levi Setti PE

Fertil Steril. 2017 May;107(5):1173-1180. doi: 10.1016/j.fertnstert.2017.03.007. Epub 2017 Apr 19.. 2017 doi:

Dual ovarian stimulation and random start in assisted reproductive technologies: from ovarian biology to clinical application.
Vaiarelli A, Venturella R, Vizziello D, Bulletti F, Ubaldi FM

Curr Opin Obstet Gynecol. 2017 Jun;29(3):153-159. doi: 10.1097/GCO.0000000000000365.. 2017 doi:

Pre-implantation genetic testing in ART: who will benefit and what is the evidence?
Vaiarelli A, Cimadomo D, Capalbo A, Orlando G, Sapienza F, Colamaria S, Palagiano A, Bulletti C, Rienzi L, Ubaldi FM

.J Assist Reprod Genet. 2016 Oct;33(10):1273-1278. doi: 10.1007/s10815-016-0785-2. Epub 2016 Aug 5.. 2016 doi:

Failure mode and effects analysis of witnessing protocols for ensuring traceability during PGD/PGS cycles.
Cimadomo D, Ubaldi FM, Capalbo A, Maggiulli R, Scarica C, Romano S, Poggiana C, Zuccarello D, Giancani A, Vaiarelli A, Rienzi L

Reprod Biomed Online. 2016 Sep;33(3):360-9. doi: 10.1016/j.rbmo.2016.06.002. Epub 2016 Jun 23.. 2016 doi:

Follicular versus luteal phase ovarian stimulation during the same menstrual cycle (DuoStim) in a reduced ovarian reserve population results in a similar euploid blastocyst formation rate: new insight in ovarian reserve exploitation.
Ubaldi FM, Capalbo A, Vaiarelli A, Cimadomo D, Colamaria S, Alviggi C, Trabucco E, Venturella R, Vajta G, Rienzi L

Fertil Steril. 2016 Jun;105(6):1488-1495.e1. doi: 10.1016/j.fertnstert.2016.03.002. Epub 2016 Mar 25.. 2016 doi:

Reduction of multiple pregnancies in the advanced maternal age population after implementation of an elective single embryo transfer policy coupled with enhanced embryo selection: pre- and post-intervention study.
Ubaldi FM, Capalbo A, Colamaria S, Ferrero S, Maggiulli R, Vajta G, Sapienza F, Cimadomo D, Giuliani M, Gravotta E, Vaiarelli A, Rienzi L

Hum Reprod. 2015 Sep;30(9):2097-106. doi: 10.1093/humrep/dev159. Epub 2015 Jul 5.. 2015 doi:

Loop electrosurgical excision procedure: a risk for spontaneous abortion?
Ubaldi FM, Vaiarelli A, Rienzi L

.Fertil Steril. 2015 Apr;103(4):904-5. doi: 10.1016/j.fertnstert.2015.01.016. Epub 2015 Feb 3.. 2015 doi:

Management of poor responders in IVF: is there anything new?
Ubaldi F, Vaiarelli A, D'Anna R, Rienzi L

Biomed Res Int. 2014;2014:352098. doi: 10.1155/2014/352098. Epub 2014 Jul 20. . 2014 doi:

Corrigendum. Definition of a clinical strategy to enhance the efficacy, efficiency and safety of egg donation cycles with imported vitrified oocytes.
Rienzi L, Cimadomo D, Maggiulli R, Vaiarelli A, Dusi L, Buffo L, Amendola MG, Colamaria S, Giuliani M, Bruno G, Stoppa M, Ubaldi FM

Hum Reprod. 2020 Aug 1;35(8):1944. doi: 10.1093/humrep/deaa145.. 2020 doi:

Biochemical pregnancy loss after frozen embryo transfer seems independent of embryo developmental stage and chromosomal status.
Vaiarelli A, Cimadomo D, Patrizio P, Venturella R, Orlando G, Soscia D, Giancani A, Capalbo A, Rienzi L, Ubaldi FM

Reprod Biomed Online. 2018 Sep;37(3):349-357. doi: 10.1016/j.rbmo.2018.05.019. Epub 2018 Jun 30.. 2018 doi:

How fixed versus variable gonadotropin dose during controlled ovarian stimulation could influence the management of infertility patients undergoing IVF treatment: a national Delphi consensus.
Bulletti C, Allegra A, Mignini Renzini M, Vaiarelli A

Gynecol Endocrinol. 2021 Mar;37(3):255-263. doi: 10.1080/09513590.2020.1770214. Epub 2020 Jun 26.. 2021 doi:

Heterogeneity Among Poor Ovarian Responders According to Bologna Criteria Results in Diverging Cumulative Live Birth Rates.
Romito A, Bardhi E, Errazuriz J, Blockeel C, Santos-Ribeiro S, Vos M, Racca A, Mackens S, Kelen AV, Panici PB, Vaiarelli A, Tournaye H, Drakopoulos P

Front Endocrinol (Lausanne). 2020 Apr 16;11:208. doi: 10.3389/fendo.2020.00208. eCollection 2020.. 2020 doi:

Cumulative live birth rates in in-vitro fertilization.
Drakopoulos P, Errázuriz J, Santos-Ribeiro S, Tournaye H, Vaiarelli A, Pluchino N, Blockeel C, Polyzos NP

Minerva Ginecol. 2019 Jun;71(3):207-210. doi: 10.23736/S0026-4784.18.04347-2. Epub 2018 Nov 27.. 2019 doi:

Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: implications for fertility.
Fiorentino G, Cimadomo D, Innocenti F, Soscia D, Vaiarelli A, Ubaldi FM, Gennarelli G, Garagna S, Rienzi L, Zuccotti M

Hum Reprod Update. 2023 Jan 5;29(1):1-23. doi: 10.1093/humupd/dmac031.. 2023 doi:

Male factor infertility and assisted reproductive technologies: indications, minimum access criteria and outcomes.
Mazzilli R, Rucci C, Vaiarelli A, Cimadomo D, Ubaldi FM, Foresta C, Ferlin AJ

Endocrinol Invest. 2023 Jan 12. doi: 10.1007/s40618-022-02000-4. Online ahead of print.. 2023 doi:

Towards Automation in IVF: Pre-Clinical Validation of a Deep Learning-Based Embryo Grading System during PGT-A Cycles.
Cimadomo D, Chiappetta V, Innocenti F, Saturno G, Taggi M, Marconetto A, Casciani V, Albricci L, Maggiulli R, Coticchio G, Ahlström A, Berntsen J, Larman M, Borini A, Vaiarelli A, Ubaldi FM, Rienzi L

J Clin Med. 2023 Feb 23;12(5):1806. doi: 10.3390/jcm12051806.. 2023 doi:

Double stimulation for the management of poor-prognosis patients: where are we going?
Petrone P, Vaiarelli A, Blockeel C

Curr Opin Obstet Gynecol. 2023 Mar 7. doi: 10.1097/GCO.0000000000000869. Online ahead of print.. 2023 doi:

Neither rationale nor scientific evidence exist to support that double stimulation is potentially unsafe.
Casarini L, Vaiarelli A, Cimadomo D, Santi D, Simoni M, Garcìa-Velasco JA, Alviggi C, La Marca A, Rienzi L, Ubaldi FM

Hum Reprod. 2022 Apr 8:deac064. Online ahead of print. 2022 doi: 10.1093/humrep/deac064

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