Giovanni Coticchio, PhD

Publications

The first mitotic division: a perilous bridge connecting the zygote and the early embryo.
Coticchio G, Cimadomo D, Cermisoni GC, Rienzi L, Papaleo E, Ubaldi FM, Borini A, De Santis L

Hum Reprod. 2023 Apr 7:dead067. doi: 10.1093/humrep/dead067. Online ahead of print.. 2023 doi:

Fertility preservation in women with benign gynaecological conditions.
Santulli P, Blockeel C, Bourdon M, Coticchio G, Campbell A, De Vos M, Macklon KT, Pinborg A, Garcia-Velasco JA

Hum Reprod Open. 2023 Apr 6;2023(2):hoad012. doi: 10.1093/hropen/hoad012. eCollection 2023. . 2023 doi:

Endometriosis affects the number of retrieved oocytes but not early embryonic development and live birth: a retrospective analysis of 716 IVF cycles.
Bartolacci A, dell Aquila M, Coticchio G, Intra G, Parodi F, Patria G, Zacà C, Borini A

Hum Fertil (Camb). 2023 May 4:1-8. doi: 10.1080/14647273.2023.2200979. Online ahead of print.. 2023 doi:

Humidified atmosphere in a time-lapse embryo culture system does not improve ongoing pregnancy rate: a retrospective propensity score model study derived from 496 first ICSI cycles.
Bartolacci A, Borini A, Cimadomo D, Fabozzi G, Maggiulli R, Lagalla C, Pignataro D, dell'Aquila M, Parodi F, Patria G, Zacà C, Ubaldi FM, Rienzi L, Coticchio G

J Assist Reprod Genet. 2023 May 3. doi: 10.1007/s10815-023-02818-8. Online ahead of print. . 2023 doi:

Maternal age affects pronuclear and chromatin dynamics, morula compaction and cell polarity, and blastulation of human embryos.
Ezoe K, Miki T, Akaike H, Shimazaki K, Takahashi T, Tanimura Y, Amagai A, Sawado A, Mogi M, Kaneko S, Ueno S, Coticchio G, Cimadomo D, Borini A, Rienzi L, Kato K

Hum Reprod. 2023 Jan 16:dead001. doi: 10.1093/humrep/dead001. Online ahead of print.. 2023 doi:

Towards Automation in IVF: Pre-Clinical Validation of a Deep Learning-Based Embryo Grading System during PGT-A Cycles.
Cimadomo D, Chiappetta V, Innocenti F, Saturno G, Taggi M, Marconetto A, Casciani V, Albricci L, Maggiulli R, Coticchio G, Ahlström A, Berntsen J, Larman M, Borini A, Vaiarelli A, Ubaldi FM, Rienzi L

J Clin Med. 2023 Feb 23;12(5):1806. doi: 10.3390/jcm12051806.. 2023 doi:

The first mitotic division: a perilous bridge connecting the zygote and the early embryo.
Coticchio G, Cimadomo D, Cermisoni GC, Rienzi L, Papaleo E, Ubaldi FM, Borini A, De Santis L

Hum Reprod. 2023 Apr 7:dead067. doi: 10.1093/humrep/dead067. Online ahead of print.. 2023 doi:

Endometriosis affects the number of retrieved oocytes but not early embryonic development and live birth: a retrospective analysis of 716 IVF cycles.
Bartolacci A, dell'Aquila M, Coticchio G, Intra G, Parodi F, Patria G, Zacà C, Borini A

Hum Fertil (Camb). 2023 May 4:1-8. doi: 10.1080/14647273.2023.2200979. Online ahead of print.. 2023 doi:

Humidified atmosphere in a time-lapse embryo culture system does not improve ongoing pregnancy rate: a retrospective propensity score model study derived from 496 first ICSI cycles.
Bartolacci A, Borini A, Cimadomo D, Fabozzi G, Maggiulli R, Lagalla C, Pignataro D, dell'Aquila M, Parodi F, Patria G, Zacà C, Ubaldi FM, Rienzi L, Coticchio G

J Assist Reprod Genet. 2023 May 3. doi: 10.1007/s10815-023-02818-8. Online ahead of print. . 2023 doi:

ESHRE survey results and good practice recommendations on managing chromosomal mosaicism.
ESHRE Working Group on Chromosomal Mosaicism, De Rycke M, Capalbo A, Coonen E, Coticchio G, Fiorentino F, Goossens V, Mcheik S, Rubio C, Sermon K, Sfontouris I, Spits C, Vermeesch JR, Vermeulen N, Wells D, Zambelli F, Kakourou G

Hum Reprod Open. 2022 Nov 7;2022(4):hoac044. doi: 10.1093/hropen/hoac044. eCollection 2022.. 2022 doi:

Human 1PN and 3PN zygotes recapitulate all morphokinetic events of normal fertilization but reveal novel developmental errors.
Ezoe K, Takahashi T, Shimazaki K, Miki T, Tanimura Y, Amagai A, Sawado A, Akaike H, Mogi M, Kaneko S, Kato M, Kato K, Tarozzi N, Borini A, Coticchio G

Hum Reprod. 2022 Sep 30;37(10):2307-2319. doi: 10.1093/humrep/deac177.. 2022 doi:

Human blastocyst spontaneous collapse is associated with worse morphological quality and higher degeneration and aneuploidy rates: a comprehensive analysis standardized through artificial intelligence.
Cimadomo D, Marconetto A, Trio S, Chiappetta V, Innocenti F, Albricci L, Erlich I, Ben-Meir A, Har-Vardi I, Kantor B, Sakov A, Coticchio G, Borini A, Ubaldi FM, Rienzi L

Hum Reprod. 2022 Sep 30;37(10):2291-2306. doi: 10.1093/humrep/deac175.. 2022 doi:

Fertilization signatures as biomarkers of embryo quality.
Coticchio G, Borini A, Zacà C, Makrakis E, Sfontouris I

Hum Reprod. 2022 Jul 30;37(8):1704-1711. doi: 10.1093/humrep/deac123.. 2022 doi:

Use of mineral oil in IVF culture systems: physico-chemical aspects, management, and safety.
Scarica C, Monaco A, Borini A, Pontemezzo E, Bonanni V, De Santis L, Zacà C, Coticchio G, SIERR, Società Italiana di Embriologia Riproduzione e Ricerca

J Assist Reprod Genet. 2022 Apr;39(4):883-892. doi: 10.1007/s10815-022-02479-z. Epub 2022 Apr 21.. 2022 doi:

Fine-tuning IVF laboratory key performance indicators of the Vienna consensus according to female age.
Zacà C, Coticchio G, Vigiliano V, Lagalla C, Nadalini M, Tarozzi N, Borini A

J Assist Reprod Genet. 2022 Apr;39(4):945-952. doi: 10.1007/s10815-022-02468-2. Epub 2022 Mar 26. . 2022 doi:

The paternal toolbox for embryo development and health.
Tarozzi N, Nadalini M, Coticchio G, Zacà C, Lagalla C, Borini A

Mol Hum Reprod. 2021 Jul 1;27(7):gaab042. doi: 10.1093/molehr/gaab042.. 2021 doi:

Plasticity of the human preimplantation embryo: developmental dogmas, variations on themes and self-correction.
Coticchio G, Barrie A, Lagalla C, Borini A, Fishel S, Griffin D, Campbell A

Hum Reprod Update. 2021 Aug 20;27(5):848-865. doi: 10.1093/humupd/dmab016.. 2021 doi:

Perturbations of morphogenesis at the compaction stage affect blastocyst implantation and live birth rates.
Coticchio G, Ezoe K, Lagalla C, Shimazaki K, Ohata K, Ninomiya M, Wakabayashi N, Okimura T, Uchiyama K, Kato K, Borini A

Hum Reprod. 2021 Mar 18;36(4):918-928. doi: 10.1093/humrep/deab011.. 2021 doi:

Sperm count affects cumulative birth rate of assisted reproduction cycles in relation to ovarian response.
Zacà C, Coticchio G, Tarozzi N, Nadalini M, Lagalla C, Garolla A, Borini A

J Assist Reprod Genet. 2020 Jul;37(7):1653-1659. doi: 10.1007/s10815-020-01807-5. Epub 2020 May 13.. 2020 doi:

Alternative patterns of partial embryo compaction: prevalence, morphokinetic history and possible implications.
Lagalla C, Coticchio G, Sciajno R, Tarozzi N, Zacà C, Borini A

Reprod Biomed Online. 2020 Mar;40(3):347-354. doi: 10.1016/j.rbmo.2019.11.011. Epub 2019 Dec 1.. 2019 doi:

Male factor infertility impacts the rate of mosaic blastocysts in cycles of preimplantation genetic testing for aneuploidy.
Tarozzi N, Nadalini M, Lagalla C, Coticchio G, Zacà C, Borini A

J Assist Reprod Genet. 2019 Oct;36(10):2047-2055. doi: 10.1007/s10815-019-01584-w. Epub 2019 Oct 19.. 2019 doi:

The enigmatic morula: mechanisms of development, cell fate determination, self-correction and implications for ART.
Coticchio G, Lagalla C, Sturmey R, Pennetta F, Borini A

Hum Reprod Update. 2019 Jul 1;25(4):422-438. doi: 10.1093/humupd/dmz008.. 2019 doi:

Practical Clinical and Diagnostic Pathway for the Investigation of the Infertile Couple.
Garolla A, Pizzol D, Carosso AR, Borini A, Ubaldi FM, Calogero AE, Ferlin A, Lanzone A, Tomei F, Engl B, Rienzi L, De Santis L, Coticchio G, Smith L, Cannarella R, Anastasi A, Menegazzo M, Stuppia L, Corsini C, Foresta C

Front Endocrinol (Lausanne). 2021 Jan 19;11:591837. doi: 10.3389/fendo.2020.591837. eCollection 2020.. 2021 doi:

Revised guidelines for good practice in IVF laboratories (2015).
ESHRE Guideline Group on Good Practice in IVF Labs, De los Santos MJ, Apter S, Coticchio G, Debrock S, Lundin K, Plancha CE, Prados F, Rienzi L, Verheyen G, Woodward B, Vermeulen N

Hum Reprod. 2016 Apr;31(4):685-6. doi: 10.1093/humrep/dew016. Epub 2016 Feb 17.. 2016 doi:

Oocyte aging: looking beyond chromosome segregation errors.
Bebbere D, Coticchio G, Borini A, Ledda S

J Assist Reprod Genet. 2022 Apr;39(4):793-800. doi: 10.1007/s10815-022-02441-z. Epub 2022 Feb 25.. 2022 doi:

Does morphological assessment predict oocyte developmental competence? A systematic review and proposed score.
Bartolacci A, Intra G, Coticchio G, dell'Aquila M, Patria G, Borini A

J Assist Reprod Genet. 2022 Jan;39(1):3-17. doi: 10.1007/s10815-021-02370-3. Epub 2022 Jan 7.. 2022 doi:

Spatiotemporal perturbations of pronuclear breakdown preceding syngamy affect early human embryo development: a retrospective observational study.
Ezoe K, Coticchio G, Takenouchi H, Taoda S, Namerikawa S, Honda K, Miki T, Okimura T, Kobayashi T, Borini A, Kato K

J Assist Reprod Genet. 2022 Jan;39(1):75-84. doi: 10.1007/s10815-021-02335-6. Epub 2021 Oct 12.. 2022 doi:

The subcortical maternal complex: emerging roles and novel perspectives.
Bebbere D, Albertini DF, Coticchio G, Borini A, Ledda S

Mol Hum Reprod. 2021 Jul 1;27(7):gaab043. doi: 10.1093/molehr/gaab043.. 2021 doi:

The slippery slope antedating syngamy: pronuclear activity in preparation for the first cleavage.
Coticchio G, Borini A, Albertini DF

J Assist Reprod Genet. 2021 Jul;38(7):1721-1723. doi: 10.1007/s10815-021-02238-6. Epub 2021 May 30.. 2021 doi:

Genetic causes of preimplantation embryo developmental failure.
Paonessa M, Borini A, Coticchio G

Mol Reprod Dev. 2021 May;88(5):338-348. doi: 10.1002/mrd.23471. Epub 2021 Apr 12.. 2021 doi:

Embryo morphokinetic score is associated with biomarkers of developmental competence and implantation.
Coticchio G, Pennetta F, Rizzo R, Tarozzi N, Nadalini M, Orlando G, Centonze C, Gioacchini G, Borini A

J Assist Reprod Genet. 2021 Jul;38(7):1737-1743. doi: 10.1007/s10815-021-02162-9. Epub 2021 Apr 5.. 2021 doi:

Gonadotropin-releasing hormone antagonist linzagolix: possible treatment for assisted reproduction patients presenting with adenomyosis and endometriosis?
Borini A, Coticchio G

Fertil Steril. 2020 Sep;114(3):517-518. doi: 10.1016/j.fertnstert.2020.06.003. Epub 2020 Aug 3.. 2020 doi:

Importance of early and precise ascertainment of mosaic Turner syndrome for fertility preservation and assisted reproduction counseling.
Borini A, Coticchio G

Fertil Steril. 2020 Aug;114(2):269-270. doi: 10.1016/j.fertnstert.2020.04.061. Epub 2020 Jul 2. . 2020 doi:

Oocyte quantity and quality are crucial for a perspective of fertility preservation in women with Turner syndrome.
Borini A, Coticchio G

Fertil Steril. 2019 Mar;111(3):461-462. doi: 10.1016/j.fertnstert.2018.12.009. Epub 2019 Feb 2.. 2019 doi:

Cumulative live birth rate in freeze-all cycles is comparable to that of a conventional embryo transfer policy at the cleavage stage but superior at the blastocyst stage.
Zacà C, Bazzocchi A, Pennetta F, Bonu MA, Coticchio G, Borini A

Fertil Steril. 2018 Sep;110(4):703-709. doi: 10.1016/j.fertnstert.2018.05.012.. 2018 doi:

Does the molecular and metabolic profile of human granulosa cells correlate with oocyte fate? New insights by Fourier transform infrared microspectroscopy analysis.
Gioacchini G, Notarstefano V, Sereni E, Zacà C, Coticchio G, Giorgini E, Vaccari L, Carnevali O, Borini A

Mol Hum Reprod. 2018 Nov 1;24(11):521-532. doi: 10.1093/molehr/gay035.. 2018 doi:

Fertility technologies and how to optimize laboratory performance to support the shortening of time to birth of a healthy singleton: a Delphi consensus.
Coticchio G, Behr B, Campbell A, Meseguer M, Morbeck DE, Pisaturo V, Plancha CE, Sakkas D, Xu Y, D'Hooghe T, Cottell E, Lundin K

J Assist Reprod Genet. 2021 May;38(5):1021-1043. doi: 10.1007/s10815-021-02077-5. Epub 2021 Feb 18.. 2021 doi:

ESHRE PGT Consortium and SIG Embryology good practice recommendations for polar body and embryo biopsy for PGT.
ESHRE PGT Consortium and SIG-Embryology Biopsy Working Group, Kokkali G, Coticchio G, Bronet F, Celebi C, Cimadomo D, Goossens V, Liss J, Nunes S, Sfontouris I, Vermeulen N, Zakharova E, De Rycke M

Hum Reprod Open. 2020 May 29;2020(3):hoaa020. doi: 10.1093/hropen/hoaa020. eCollection 2020.. 2020 doi:

Good practice recommendations for the use of time-lapse technology†.
ESHRE Working group on Time-lapse technology, Apter S, Ebner T, Freour T, Guns Y, Kovacic B, Le Clef N, Marques M, Meseguer M, Montjean D, Sfontouris I, Sturmey R, Coticchio G

Hum Reprod Open. 2020 Mar 19;2020(2):hoaa008. doi: 10.1093/hropen/hoaa008. eCollection 2020.. 2020 doi:

Should we still perform fresh embryo transfers in ART?
Blockeel C, Campbell A, Coticchio G, Esler J, Garcia-Velasco JA, Santulli P, Pinborg A

Hum Reprod. 2019 Dec 1;34(12):2319-2329. doi: 10.1093/humrep/dez233.. 2019 doi:

Maternal age affects pronuclear and chromatin dynamics, morula compaction and cell polarity, and blastulation of human embryos.
Ezoe K, Miki T, Akaike H, Shimazaki K, Takahashi T, Tanimura Y, Amagai A, Sawado A, Mogi M, Kaneko S, Ueno S, Coticchio G, Cimadomo D, Borini A, Rienzi L, Kato K

Hum Reprod. 2023 Jan 16:dead001. doi: 10.1093/humrep/dead001. Online ahead of print.. 2023 doi:

Towards Automation in IVF: Pre-Clinical Validation of a Deep Learning-Based Embryo Grading System during PGT-A Cycles.
Cimadomo D, Chiappetta V, Innocenti F, Saturno G, Taggi M, Marconetto A, Casciani V, Albricci L, Maggiulli R, Coticchio G, Ahlström A, Berntsen J, Larman M, Borini A, Vaiarelli A, Ubaldi FM, Rienzi L

J Clin Med. 2023 Feb 23;12(5):1806. doi: 10.3390/jcm12051806.. 2023 doi:

ESHRE survey results and good practice recommendations on managing chromosomal mosaicism.
ESHRE Working Group on Chromosomal Mosaicism, De Rycke M, Capalbo A, Coonen E, Coticchio G, Fiorentino F, Goossens V, Mcheik S, Rubio C, Sermon K, Sfontouris I, Spits C, Vermeesch JR, Vermeulen N, Wells D, Zambelli F, Kakourou G

Hum Reprod Open. 2022 Nov 7;2022(4):hoac044. doi: 10.1093/hropen/hoac044. eCollection 2022.. 2022 doi:

B.Sc. (Biology)	University of Palermo, Italy (1985)
Ph.D. (Cell and Developmental Biology)	University of Palermo, Italy (1991)
M.Med.Sci. (A.R.T.)	University of Nottingham, UK (1995)
M.Med.Sci. (Reproductive Medicine)	University of Padova, Italy (2009)
Data management for clinical research	Vanderbilt University, USA (2013)
Writing in the Sciences	Stanford School of Medicine, USA (2013)

Fertility Researchers

OUR INVESTIGATORS

Biography

Education and Training

Honors and recognition

Publications

Presentations

Qualification of full Professorship in Health and Medical Technology awarded by Italian Ministry of Education, University and Scientific Research	2018
Qualification of full Professorship in Obstetrics and Gynaecology awarded by Italian Ministry of Education, University and Scientific Research	2020
Birth Grant	2020