Filippo Ubaldi, M.D.

Biography

Filippo Maria Ubaldi is the Medical Director Italy and member of the Medical Council of IVIRMA Global, International Reproductive Medicine network. He is also member of the Scientific Advisory Board of IVIRMA Global Research Alliance.

He is member of the Technical Table for in-depth study of issues related to medically assisted procreation, established by the Italian Ministry of Health on January 2023.

With academic degrees in Ob & Gyn, Masters in Andrology and Reproductive Medicine, PhD in Andrology at the Vrije Universiteit Brussel, he is also intensely dedicated to scientific activity.

Author and co-author >230 scientific papers with Scopus H-index of 59, he has been invited as speaker at >600 National and International congresses on the topic of Reproductive Medicine.

Section Editor of the journal RBM Online, he serves as reviewer in more than 10 scientific journals.

Member of the ESHRE Executive Committee during 2005-2009, he has been Chairman of the 26th ESHRE Annual Meeting held in Rome in June 2010.

In 2008 he founded together with Prof. Laura Rienzi the Genera IVF centers, with four different locations in Italy, where he has been Clinical Director.

In 2014 and 2019 he received the Italian National Scientific License as full Professor in Obstetrics and Gynaecology and at the present is the Chairman of the Italian Society of Fertility and Sterility (SIFES).

In 2020, he was actively involved in the creation of GeneraLife, a network of >30 clinics in 5 different countries in Europe: the name GeneraLife was inspired by the group he founded 12 years before.

Education and Training

B.Sc. Medicine and Surgery	University of Rome ‘La Sapienza’ (1989)
M.Sc. Obstetrics and Gynecology	University of Chieti “Gabriele D’Annunzio” di Chieti (1993)
Post-graduate Fellowship	University of Brussels Vrije Universiteit Brussel (1993-1996)
M.Sc. Andrology	University of Padua (2008)
M.Sc. Reproductive Medicine	University of Padua (2010)
Ph.D.	University of Brussels Vrije Universiteit Brussel (2018)

Honors and recognition

Member of the Technical Table for Research and Training in Infertility Prevention and Treatment	2021 to present
Expert for peer review of research products submitted for VQR 2011-2014	Ministry of Scientific Research, 2014-2015
Member of the advisory table on fertility protection and prevention of the causes of infertility established by the Ministry of Health	2014-2015
Member of the technical table on heterologous assisted reproduction established by the Ministry of Health	2014
Professor in "Applied Human Embryology" Master at Roma Tre University	2019-2023
Professor in "Reproductive Health, Endoscopic Techniques and Medically Assisted Procreation" at University of Florence	2019
Scientific Coordinator of the Master in "Reproductive Sciences and Medically Assisted Reproductive Techniques" at University of Urbino, Carlo Bò	2015-2019
Professor in "Reproductive Medicine" master at the University of Padua	2009-2019
Adjunct Professor in Neuroendocrinology of Human Reproduction at the School of Specialization in Obstetrics and Gynecology, , University of Perugia	2006-2007
Adjunct Professor in Endocrinology of the Menstrual Cycle at the School of Specialization in Obstetrics and Gynecology, University of Perugia	2004-2005
Adjunct Professor in Endocrinology in Assisted Fertilization at the School of Specialization in Obstetrics and Gynecology, University of Perugia	2000-2004

Publications

Role of thyroid stimulating hormone in the maintenance and functioning of the human corpus luteum.
Taggi M, Capponi C, Bertani N, Saturno G, Innocenti F, Dovere L, Fabozzi SM, Alesiani O, Arena V, Cimadomo D, Mazzilli R, Rienzi L, Ubaldi FM, Canipari R, Vicini E, Apa R

.J Endocrinol Invest. 2024 Jan 8. doi: 10.1007/s40618-023-02269-z. Online ahead of print.. 2024 doi:

Innovative Strategies for Fertility Preservation in Female Cancer Survivors: New Hope from Artificial Ovary Construction and Stem Cell-Derived Neo-Folliculogenesis.
Canosa S, Revelli A, Gennarelli G, Cormio G, Loizzi V, Arezzo F, Petracca EA, Carosso AR, Cimadomo D, Rienzi L, Vaiarelli A, Ubaldi FM, Silvestris E

Healthcare (Basel). 2023 Oct 17;11(20):2748. doi: 10.3390/healthcare11202748.. 2023 doi:

Correction to: The HERA (Hyper‑response Risk Assessment) Delphi consensus for the management of hyper‑responders in in vitro fertilization.
Feferkorn I, Santos-Ribeiro S, Ubaldi FM, Velasco JG, Ata B, Blockeel C, Conforti A, Esteves SC, Fatemi HM, Gianaroli L, Grynberg M, Humaidan P, Lainas GT, La Marca A, Craig LB, Lathi R, Norman RJ, Orvieto R, Paulson R, Pellicer A, Polyzos NP, Roque M, Sunkara SK, Tan SL, Urman B, Venetis C, Weissman A, Yarali H, Dahan MH

J Assist Reprod Genet. 2023 Dec 11. doi: 10.1007/s10815-023-03003-7. Online ahead of print.. 2023 doi:

Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: implications for fertility.
Fiorentino G, Cimadomo D, Innocenti F, Soscia D, Vaiarelli A, Ubaldi FM, Gennarelli G, Garagna S, Rienzi L, Zuccotti M

Hum Reprod Update. 2023 Jan 5;29(1):1-23. doi: 10.1093/humupd/dmac031.. 2023 doi:

Clinical and laboratory key performance indicators in IVF: A consensus between the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR) and the Italian Society of Embryology, Reproduction and Research (SIERR).
Vaiarelli A, Zaca C, Spadoni V, Cimadomo D, Conforti A, Alviggi C, Palermo R, Bulletti C, De Santis L, Pisaturo V, Vigiliano V, Scaravelli G, Ubaldi FM, Borini A

J Assist Reprod Genet. 2023 Apr 24. doi: 10.1007/s10815-023-02792-1. Online ahead of print.. 2023 doi:

Cryostorage management of reproductive cells and tissues in ART: status, needs, opportunities, and potential new challenges
Canosa S, Maggiulli R, Cimadomo D, Innocenti F, Fabozzi G, Gennarelli G, Revelli A, Bongioanni F, Vaiarelli A, Ubaldi FM, Rienzi L, Palmer GA, Nijs M

Reproductive BioMedicine Online Available online 22 June 202 In press. 2023 doi:

From a cycle-by-cycle to a multi-cycle treatment planning: the next relevant shift in perspective needed in ART?
Faustini F, Cimadomo D, Ubaldi FM, Rienzi L

Fertil Steril. 2023 May 8:S0015-0282(23)00372-2. doi: 10.1016/j.fertnstert.2023.05.001. Online ahead of print. . 2023 doi:

How should the best human embryo in vitro be? Current and future challenges for embryo selection.
Cimadomo D, Innocenti F, Taggi M, Saturno G, Campitiello MR, Guido M, Vaiarelli A, Ubaldi FM, Rienzi L

Minerva Obstet Gynecol. 2023 Jun 16. doi: 10.23736/S2724-606X.23.05296-X. Online ahead of print.. 2023 doi:

Humidified atmosphere in a time-lapse embryo culture system does not improve ongoing pregnancy rate: a retrospective propensity score model study derived from 496 first ICSI cycles.
Bartolacci A, Borini A, Cimadomo D, Fabozzi G, Maggiulli R, Lagalla C, Pignataro D, dell'Aquila M, Parodi F, Patria G, Zacà C, Ubaldi FM, Rienzi L, Coticchio G

J Assist Reprod Genet. 2023 May 3. doi: 10.1007/s10815-023-02818-8. Online ahead of print. . 2023 doi:

Improved clinical utility of preimplantation genetic testing through the integration of ploidy and common pathogenic microdeletions analyses.
Caroselli S, Figliuzzi M, Picchetta L, Cogo F, Zambon P, Pergher I, Girardi L, Patassini C, Poli M, Bakalova D, Cimadomo D, Findikli N, Coban O, Serdarogullari M, Favero F, Bortolato S, Anastasi A, Capodanno F, Gallinelli A, Brancati F, Rienzi L, Ubaldi FM, Jimenez-Almazán J, Blesa-Jarque D, Miravet-Valenciano J, Rubio C, Simòn C, Capalbo A

Hum Reprod. 2023 Feb 22:dead033. doi: 10.1093/humrep/dead033. Online ahead of print.. 2023 doi:

Low-quality evidence from a randomized controlled trial due to an inappropriate IVF setting to challenge Dual Stimulation strategy.
Ubaldi FM, Vaiarelli A, Cimadomo D, Cerrillo M, Rienzi L, Garcia-Velasco JA

Hum Reprod. 2023 Jun 5:dead108. doi: 10.1093/humrep/dead108. Online ahead of print.. 2023 doi:

Male factor infertility and assisted reproductive technologies: indications, minimum access criteria and outcomes.
Mazzilli R, Rucci C, Vaiarelli A, Cimadomo D, Ubaldi FM, Foresta C, Ferlin AJ

Endocrinol Invest. 2023 Jan 12. doi: 10.1007/s40618-022-02000-4. Online ahead of print.. 2023 doi:

Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis.
Cimadomo D, Rienzi L, Conforti A, Forman E, Canosa S, Innocenti F, Poli M, Hynes J, Gemmell L, Vaiarelli A, Alviggi C, Ubaldi FM, Capalbo A

Hum Reprod Update. 2023 May 16:dmad010. doi: 10.1093/humupd/dmad010. Online ahead of print.. 2023 doi:

The first mitotic division: a perilous bridge connecting the zygote and the early embryo.
Coticchio G, Cimadomo D, Cermisoni GC, Rienzi L, Papaleo E, Ubaldi FM, Borini A, De Santis L

Hum Reprod. 2023 Apr 7:dead067. doi: 10.1093/humrep/dead067. Online ahead of print.. 2023 doi:

Towards Automation in IVF: Pre-Clinical Validation of a Deep Learning-Based Embryo Grading System during PGT-A Cycles.
Cimadomo D, Chiappetta V, Innocenti F, Saturno G, Taggi M, Marconetto A, Casciani V, Albricci L, Maggiulli R, Coticchio G, Ahlström A, Berntsen J, Larman M, Borini A, Vaiarelli A, Ubaldi FM, Rienzi L

J Clin Med. 2023 Feb 23;12(5):1806. doi: 10.3390/jcm12051806.. 2023 doi:

DuoStim reduces time to pregnancy, minimizes treatment discontinuation, and is potentially cost-effective.
Garcia-Velasco JA, Cimadomo D, Cerrillo M, Vaiarelli A, Ubaldi FM

Hum Reprod. 2023 Jun 23:dead113. doi: 10.1093/humrep/dead113. Online ahead of print.. 2023 doi:

Metaphase-II oocyte competence is unlinked to the gonadotrophins used for ovarian stimulation: a matched case-control study in women of advanced maternal age.
Vaiarelli A, Cimadomo D, Scarafia C, Innocenti F, Amendola MG, Fabozzi G, Casarini L, Conforti A, Alviggi C, Gennarelli G, Benedetto C, Guido M, Borini A, Rienzi L, Ubaldi FM

J Assist Reprod Genet. 2023 Jan;40(1):169-177. doi: 10.1007/s10815-022-02684-w. Epub 2022 Dec 31.. 2023 doi:

The HERA (Hyper-response Risk Assessment) Delphi consensus definition of hyper-responders for in-vitro fertilization.
Feferkorn I, Ata B, Esteves SC, La Marca A, Paulson R, Blockeel C, Conforti A, Fatemi HM, Humaidan P, Lainas GT, Mol BW, Norman RJ, Orvieto R, Polyzos NP, Santos-Ribeiro S, Sunkara SK, Tan SL, Ubaldi FM, Urman B, Velasco JG, Weissman A, Yarali H, Dahan MH

J Assist Reprod Genet. 2023 Mar 18. doi: 10.1007/s10815-023-02757-4. Online ahead of print.. 2023 doi:

The HERA (Hyper-response Risk Assessment) Delphi consensus for the management of hyper-responders in in vitro fertilization.
Feferkorn I, Santos-Ribeiro S, Ubaldi FM, Velasco JG, Ata B, Blockeel C, Conforti A, Esteves SC, Fatemi HM, Gianaroli L, Grynberg M, Humaidan P, Lainas GT, La Marca A, LaTasha C, Lathi R, Norman RJ, Orvieto R, Paulson R, Pellicer A, Polyzos NP, Roque M, Sunkara SK, Tan SL, Urman B, Venetis C, Weissman A, Yarali H, Dahan MH

J Assist Reprod Genet. 2023 Sep 15. doi: 10.1007/s10815-023-02918-5. Online ahead of print.. 2023 doi:

Avoid mixing apples and oranges: blastocysts diagnosed with uniform whole chromosome aneuploidies are reproductively incompetent and their transfer is harmful.
Capalbo A, Cimadomo D, Rienzi L, Garcìa-Velasco JA, Simòn C, Ubaldi FM

Hum Reprod. 2022 Aug 25;37(9):2213-2214. doi: 10.1093/humrep/deac149.. 2022 doi:

Neither rationale nor scientific evidence exist to support that double stimulation is potentially unsafe.
Casarini L, Vaiarelli A, Cimadomo D, Santi D, Simoni M, Garcìa-Velasco JA, Alviggi C, La Marca A, Rienzi L, Ubaldi FM

Hum Reprod. 2022 Jul 30;37(8):1949-1950. doi: 10.1093/humrep/deac064.. 2022 doi:

Clinical, obstetric and perinatal outcomes after vitrified-warmed euploid blastocyst transfer are independent of cryo-storage duration.
Cimadomo D, Fabozzi G, Dovere L, Maggiulli R, Albricci L, Innocenti F, Soscia D, Giancani A, Vaiarelli A, Guido M, Ubaldi FM, Rienzi L

Reprod Biomed Online. 2022 Feb;44(2):221-227. doi: 10.1016/j.rbmo.2021.09.027. Epub 2021 Oct 8.. 2022 doi:

Endocrine-Disrupting Chemicals, Gut Microbiota, and Human (In)Fertility-It Is Time to Consider the Triad.
Fabozzi G, Rebuzzini P, Cimadomo D, Allori M, Franzago M, Stuppia L, Garagna S, Ubaldi FM, Zuccotti M, Rienzi L

Cells. 2022 Oct 22;11(21):3335. doi: 10.3390/cells11213335. . 2022 doi:

How slow is too slow? A comprehensive portrait of Day 7 blastocysts and their clinical value standardized through artificial intelligence.
Cimadomo D, Soscia D, Casciani V, Innocenti F, Trio S, Chiappetta V, Albricci L, Maggiulli R, Erlich I, Ben-Meir A, Har-Vardi I, Vaiarelli A, Ubaldi FM, Rienzi L

Hum Reprod. 2022 May 30;37(6):1134-1147. doi: 10.1093/humrep/deac080. . 2022 doi:

Human blastocyst spontaneous collapse is associated with worse morphological quality and higher degeneration and aneuploidy rates: a comprehensive analysis standardized through artificial intelligence.
Cimadomo D, Marconetto A, Trio S, Chiappetta V, Innocenti F, Albricci L, Erlich I, Ben-Meir A, Har-Vardi I, Kantor B, Sakov A, Coticchio G, Borini A, Ubaldi FM, Rienzi L

Hum Reprod. 2022 Sep 30;37(10):2291-2306. doi: 10.1093/humrep/deac175.. 2022 doi:

Lights and shadows of preimplantation genetic testing for aneuploidy: better focusing on the accurate report of nonmosaic aneuploidies.
Cimadomo D, Rienzi L, Ubaldi FM, Capalbo A

Fertil Steril. 2022 Feb;117(2):324-325. doi: 10.1016/j.fertnstert.2021.12.002. Epub 2021 Dec 26.. 2022 doi:

Maternal effect factors that contribute to oocytes developmental competence: an update.
Innocenti F, Fiorentino G, Cimadomo D, Soscia D, Garagna S, Rienzi L, Ubaldi FM, Zuccotti M, SIERR

J Assist Reprod Genet. 2022 Apr;39(4):861-871. doi: 10.1007/s10815-022-02434-y. Epub 2022 Feb 15.. 2022 doi:

Monozygotic twin rate among ART centers: a multicenter analysis of data from 18 Italian units.
Scaravelli G, Pisaturo V, Levi Setti PE, Ubaldi FM, Livi C, Borini A, Greco E, Villani MT, Coccia ME, Revelli A, Ricci G, Fusi F, Costa M, Migliorati E, De Luca R, Vigiliano V, Bolli S, Reschini M

J Assist Reprod Genet. 2022 Oct;39(10):2349-2354. doi: 10.1007/s10815-022-02603-z. Epub 2022 Sep 2.. 2022 doi:

Multi- and Transgenerational Effects of Environmental Toxicants on Mammalian Reproduction.
Rebuzzini P, Fabozzi G, Cimadomo D, Ubaldi FM, Rienzi L, Zuccotti M, Garagna S

Cells. 2022 Oct 9;11(19):3163. doi: 10.3390/cells11193163.. 2022 doi:

Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation.
Fabozzi G, Verdone G, Allori M, Cimadomo D, Tatone C, Stuppia L, Franzago M, Ubaldi N, Vaiarelli A, Ubaldi FM, Rienzi L, Gennarelli G

Nutrients. 2022 May 3;14(9):1918. doi: 10.3390/nu14091918.. 2022 doi:

Second stimulation in the same ovarian cycle: an option to fully-personalize the treatment in poor prognosis patients undergoing PGT-A.
Vaiarelli A, Cimadomo D, Gennarelli G, Guido M, Alviggi C, Conforti A, Livi C, Revelli A, Colamaria S, Argento C, Giuliani M, De Angelis C, Matteo M, Canosa S, D'Alfonso A, Cimadomo V, Rienzi L, Ubaldi FM

J Assist Reprod Genet. 2022 Mar;39(3):663-673. doi: 10.1007/s10815-022-02409-z. Epub 2022 Feb 7.. 2022 doi:

The actual impact of SARS-CoV-2/COVID-19 pandemic on IVF activity: a survey across Italian ART centers.
Scaravelli G, Levi Setti PE, Gennarelli G, Mencaglia L, Ubaldi FM, De Luca R, Cimadomo D, Spoletini R, Vigiliano V, Sileri PP

J Assist Reprod Genet. 2022 Oct;39(10):2373-2380. doi: 10.1007/s10815-022-02600-2. Epub 2022 Aug 23.. 2022 doi:

The effect of extended cryo-storage following vitrification on embryo competence: a systematic review and meta-analysis.
Canosa S, Cimadomo D, Conforti A, Maggiulli R, Giancani A, Tallarita A, Golia F, Fabozzi G, Vaiarelli A, Gennarelli G, Revelli A, Bongioanni F, Alviggi C, Ubaldi FM, Rienzi L, SIERR

J Assist Reprod Genet. 2022 Apr;39(4):873-882. doi: 10.1007/s10815-022-02405-3. Epub 2022 Feb 4.. 2022 doi:

The role of thyroid function in female and male infertility: a narrative review.
Mazzilli R, Medenica S, Di Tommaso AM, Fabozzi G, Zamponi V, Cimadomo D, Rienzi L, Ubaldi FM, Watanabe M, Faggiano A, La Vignera S, Defeudis G

J Endocrinol Invest. 2023 Jan;46(1):15-26. doi: 10.1007/s40618-022-01883-7. Epub 2022 Aug 9. . 2022 doi:

In vitro fertilization and andrology laboratories in 2030.
Simon C, Campbell A, Gardner DK, Meseguer M, Miller KA, Montag M, Palermo GD, Cheung S, Keating D, Xie P, Rosenwaks Z, Rienzi L, Innocenti F, Cimadomo D, Ubaldi FM, Sakkas D, Tucker MJ, Nel-Themaat L

Fertil Steril. 2021 Jul;116(1):2-3. doi: 10.1016/j.fertnstert.2021.05.089.. 2021 doi:

Blastulation rates of sibling oocytes in two IVF culture media: an evidence-based workflow to implement newly commercialized products.
Fabozzi G, Albricci L, Cimadomo D, Amendola MG, Sanges F, Maggiulli R, Ubaldi FM, Rienzi L

Reprod Biomed Online. 2021 Feb;42(2):311-322. doi: 10.1016/j.rbmo.2020.10.017. Epub 2020 Nov 4.. 2021 doi:

Clinical validity and utility of preconception expanded carrier screening for the management of reproductive genetic risk in IVF and general population.
Capalbo A, Fabiani M, Caroselli S, Poli M, Girardi L, Patassini C, Favero F, Cimadomo D, Vaiarelli A, Simon C, Rienzi LF, Ubaldi FM

Hum Reprod. 2021 Jun 18;36(7):2050-2061. doi: 10.1093/humrep/deab087. 2021 doi:

Effects of Hydrosalpinx on Endometrial Implantation Failures: Evaluating Salpingectomy in Women Undergoing in vitro fertilization.
Palagiano A, Cozzolino M, Ubaldi FM, Palagiano C, Coccia ME

Rev Bras Ginecol Obstet. 2021 Apr;43(4):304-310. doi: 10.1055/s-0040-1722155. Epub 2021 Feb 18. . 2021 doi:

Endometriosis shows no impact on the euploid blastocyst rate per cohort of inseminated metaphase-II oocytes: A case-control study.
Vaiarelli A, Venturella R, Cimadomo D, Conforti A, Pedri S, Bitonti G, Iussig B, Gentile C, Alviggi E, Santopaolo S, Zullo F, Rienzi L, Ubaldi FM

Eur J Obstet Gynecol Reprod Biol. 2021 Jan;256:205-210. doi: 10.1016/j.ejogrb.2020.11.024. Epub 2020 Nov 11.. 2021 doi:

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives.
Maggiulli R, Vaiarelli A, Cimadomo D, Giancani A, Tacconi L, Fabozzi G, Ubaldi FM, Rienzi L

J Vis Exp. 2021 Sep 16;(175). doi: 10.3791/61963.. 2021 doi:

Fertilization rate as a novel indicator for cumulative live birth rate: a multicenter retrospective cohort study of 9,394 complete in vitro fertilization cycles.
Scaravelli G, Zacà C, Levi Setti PE, Livi C, Ubaldi FM, Villani MT, Greco E, Coccia ME, Revelli A, Ricci G, Fusi F, Vigiliano V, De Luca R, Bolli S, Borini A

Fertil Steril. 2021 Sep;116(3):766-773. doi: 10.1016/j.fertnstert.2021.04.006. Epub 2021 May 8.. 2021 doi:

Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines.
Esteves SC, Conforti A, Sunkara SK, Carbone L, Picarelli S, Vaiarelli A, Cimadomo D, Rienzi L, Ubaldi FM, Zullo F, Andersen CY, Orvieto R, Humaidan P, Alviggi C

Front Endocrinol (Lausanne). 2021 Mar 19;12:587051. doi: 10.3389/fendo.2021.587051. eCollection 2021.. 2021 doi:

In vitro fertilization and andrology laboratory in 2030: expert visions.
Campbell A, Gardner DK, Meseguer M, Miller KA, Montag M, Palermo GD, Cheung S, Keating D, Xie P, Rosenwaks Z, Rienzi L, Innocenti F, Cimadomo D, Ubaldi FM, Sakkas D, Tucker MJ, Nel-Themaat L, Simon C

Fertil Steril. 2021 Jul;116(1):4-12. doi: 10.1016/j.fertnstert.2021.05.088.. 2021 doi:

Is a randomized controlled design sufficient for a trial to be valuable?
Ubaldi FM, Cimadomo D, Vaiarelli A, Rienzi L

Hum Reprod. 2021 Jul 19;36(8):2416-2417. doi: 10.1093/humrep/deab114.. 2021 doi:

Is it in our patients' blood? On a quest for predictors of blastocysts' aneuploidy rate.
Cimadomo D, Rienzi L, Ubaldi FM

Fertil Steril. 2021 Apr;115(4):888-889. doi: 10.1016/j.fertnstert.2021.02.013. Epub 2021 Feb 26.. 2021 doi:

Leave the past behind: women's reproductive history shows no association with blastocysts' euploidy and limited association with live birth rates after euploid embryo transfers.
Cimadomo D, Capalbo A, Dovere L, Tacconi L, Soscia D, Giancani A, Scepi E, Maggiulli R, Vaiarelli A, Rienzi L, Ubaldi FM

Hum Reprod. 2021 Mar 18;36(4):929-940. doi: 10.1093/humrep/deab014.. 2021 doi:

Maternal body mass index associates with blastocyst euploidy and live birth rates: the tip of an iceberg?
Fabozzi G, Cimadomo D, Allori M, Vaiarelli A, Colamaria S, Argento C, Amendola MG, Innocenti F, Soscia D, Maggiulli R, Mazzilli R, Ubaldi N, Iussig B, Marchetti M, Rienzi L, Ubaldi FM

Reprod Biomed Online. 2021 Oct;43(4):645-654. doi: 10.1016/j.rbmo.2021.07.006. Epub 2021 Jul 22.. 2021 doi:

Measuring success in IVF is a complex multidisciplinary task: time for a consensus?
Rienzi L, Cimadomo D, Vaiarelli A, Gennarelli G, Holte J, Livi C, Aura Masip M, Uher P, Fabozzi G, Ubaldi FM

Reprod Biomed Online. 2021 Nov;43(5):775-778. doi: 10.1016/j.rbmo.2021.08.012. Epub 2021 Aug 20. . 2021 doi:

Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial.
Capalbo A, Poli M, Rienzi L, Girardi L, Patassini C, Fabiani M, Cimadomo D, Benini F, Farcomeni A, Cuzzi J, Rubio C, Albani E, Sacchi L, Vaiarelli A, Figliuzzi M, Findikli N, Coban O, Boynukalin FK, Vogel I, Hoffmann E, Livi C, Levi-Setti PE, Ubaldi FM, Simón C

Am J Hum Genet. 2021 Dec 2;108(12):2238-2247. doi: 10.1016/j.ajhg.2021.11.002. Epub 2021 Nov 18.. 2021 doi:

Natural Cycle Results in Lower Implantation Failure than Ovarian Stimulation in Advanced-Age Poor Responders Undergoing IVF: Fertility Outcomes from 585 Patients.
De Marco MP, Montanari G, Ruscito I, Giallonardo A, Ubaldi FM, Rienzi L, Costanzi F, Caserta D, Schimberni M, Schimberni M

Reprod Sci. 2021 Jul;28(7):1967-1973. doi: 10.1007/s43032-020-00455-5. Epub 2021 Jan 22.. 2021 doi:

Oocyte competence is independent of the ovulation trigger adopted: a large observational study in a setting that entails vitrified-warmed single euploid blastocyst transfer.
Cimadomo D, Vaiarelli A, Petriglia C, Fabozzi G, Ferrero S, Schimberni M, Argento C, Colamaria S, Giuliani M, Ubaldi N, Rienzi L, Ubaldi FM

J Assist Reprod Genet. 2021 Jun;38(6):1419-1427. doi: 10.1007/s10815-021-02124-1. Epub 2021 Mar 4.. 2021 doi:

Perinatal and obstetric outcomes in singleton pregnancies following fresh versus cryopreserved blastocyst transfer: a meta-analysis.
Conforti A, Picarelli S, Carbone L, La Marca A, Venturella R, Vaiarelli A, Cimadomo D, Zullo F, Rienzi L, Ubaldi FM, Alviggi C

Reprod Biomed Online. 2021 Feb;42(2):401-412. doi: 10.1016/j.rbmo.2020.09.029. Epub 2020 Oct 5.. 2021 doi:

Practical Clinical and Diagnostic Pathway for the Investigation of the Infertile Couple.
Garolla A, Pizzol D, Carosso AR, Borini A, Ubaldi FM, Calogero AE, Ferlin A, Lanzone A, Tomei F, Engl B, Rienzi L, De Santis L, Coticchio G, Smith L, Cannarella R, Anastasi A, Menegazzo M, Stuppia L, Corsini C, Foresta C

Front Endocrinol (Lausanne). 2021 Jan 19;11:591837. doi: 10.3389/fendo.2020.591837. eCollection 2020.. 2021 doi:

Recombinant human luteinizing hormone co-treatment in ovarian stimulation for assisted reproductive technology in women of advanced reproductive age: a systematic review and meta-analysis of randomized controlled trials.
Conforti A, Esteves SC, Humaidan P, Longobardi S, D'Hooghe T, Orvieto R, Vaiarelli A, Cimadomo D, Rienzi L, Ubaldi FM, Zullo F, Alviggi C

Reprod Biol Endocrinol. 2021 Jun 21;19(1):91. doi: 10.1186/s12958-021-00759-4.. 2021 doi:

Reply: 'Second stimulation in the same ovarian cycle', probably a terminology more appropriate than 'luteal phase stimulation' in the DuoStim protocol.
Vaiarelli A, Cimadomo D, Rienzi L, Ubaldi FM

Hum Reprod. 2021 May 17;36(6):1723-1724. doi: 10.1093/humrep/deab018.. 2021 doi:

Severe male factor in in vitro fertilization: definition, prevalence, and treatment. An update.
Mazzilli R, Vaiarelli A, Dovere L, Cimadomo D, Ubaldi N, Ferrero S, Rienzi L, Lombardo F, Lenzi A, Tournaye H, Ubaldi FM

Asian J Androl. 2022 Mar-Apr;24(2):125-134. doi: 10.4103/aja.aja_53_21.. 2021 doi:

The Impact of Unbalanced Maternal Nutritional Intakes on Oocyte Mitochondrial Activity: Implications for Reproductive Function.
Fabozzi G, Iussig B, Cimadomo D, Vaiarelli A, Maggiulli R, Ubaldi N, Ubaldi FM, Rienzi L

Antioxidants (Basel). 2021 Jan 11;10(1):91. doi: 10.3390/antiox10010091.. 2021 doi:

Assessment and management of the risk of SARS-CoV-2 infection in an IVF laboratory.
Maggiulli R, Giancani A, Fabozzi G, Dovere L, Tacconi L, Amendola MG, Cimadomo D, Ubaldi FM, Rienzi L

Reprod Biomed Online. 2020 Sep;41(3):385-394. doi: 10.1016/j.rbmo.2020.06.017. Epub 2020 Jun 27.. 2020 doi:

Corrigendum. Definition of a clinical strategy to enhance the efficacy, efficiency and safety of egg donation cycles with imported vitrified oocytes.
Rienzi L, Cimadomo D, Maggiulli R, Vaiarelli A, Dusi L, Buffo L, Amendola MG, Colamaria S, Giuliani M, Bruno G, Stoppa M, Ubaldi FM

Hum Reprod. 2020 Aug 1;35(8):1944. doi: 10.1093/humrep/deaa145.. 2020 doi:

COVID-19 and ART: the view of the Italian Society of Fertility and Sterility and Reproductive Medicine.
Vaiarelli A, Bulletti C, Cimadomo D, Borini A, Alviggi C, Ajossa S, Anserini P, Gennarelli G, Guido M, Levi-Setti PE, Palagiano A, Palermo R, Savasi V, Pellicer A, Rienzi L, Ubaldi FM

Reprod Biomed Online. 2020 Jun;40(6):755-759. doi: 10.1016/j.rbmo.2020.04.003. Epub 2020 Apr 8.. 2020 doi:

COVID-19 and assisted reproductive technology services: repercussions for patients and proposal for individualized clinical management.
Alviggi C, Esteves SC, Orvieto R, Conforti A, La Marca A, Fischer R, Andersen CY, Bühler K, Sunkara SK, Polyzos NP, Strina I, Carbone L, Bento FC, Galliano D, Yarali H, Vuong LN, Grynberg M, Drakopoulos P, Xavier P, Llacer J, Neuspiller F, Horton M, Roque M, Papanikolaou E, Banker M, Dahan MH, Foong S, Tournaye H, Blockeel C, Vaiarelli A, Humaidan P, Ubaldi FM, POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) group

Reprod Biol Endocrinol. 2020 May 13;18(1):45. doi: 10.1186/s12958-020-00605-z.. 2020 doi:

Definition of a clinical strategy to enhance the efficacy, efficiency and safety of egg donation cycles with imported vitrified oocytes.
Rienzi L, Cimadomo D, Maggiulli R, Vaiarelli A, Dusi L, Buffo L, Amendola MG, Colamaria S, Giuliani M, Bruno G, Stoppa M, Ubaldi FM

Hum Reprod. 2020 Apr 28;35(4):785-795. doi: 10.1093/humrep/deaa009.. 2020 doi:

DuoStim - a reproducible strategy to obtain more oocytes and competent embryos in a short time-frame aimed at fertility preservation and IVF purposes. A systematic review.
Vaiarelli A, Cimadomo D, Petriglia C, Conforti A, Alviggi C, Ubaldi N, Ledda S, Ferrero S, Rienzi L, Ubaldi FM

Ups J Med Sci. 2020 May;125(2):121-130. doi: 10.1080/03009734.2020.1734694. Epub 2020 Apr 25.. 2020 doi:

Luteal phase after conventional stimulation in the same ovarian cycle might improve the management of poor responder patients fulfilling the Bologna criteria: a case series.
Vaiarelli A, Cimadomo D, Conforti A, Schimberni M, Giuliani M, D'Alessandro P, Colamaria S, Alviggi C, Rienzi L, Ubaldi FM

Fertil Steril. 2020 Jan;113(1):121-130. doi: 10.1016/j.fertnstert.2019.09.012. Epub 2019 Dec 16.. 2020 doi:

Septate uterus and reproductive outcomes: let's get serious about this.
Alonso Pacheco L, Ata B, Bettocchi S, Campo R, Carugno J, Checa MA, de Angelis C, Di Spiezio Sardo A, Donnez J, Farrugia M, Ferro J, Franchini M, Garzon S, Gianaroli L, Gergolet M, Gubbini G, Gordts S, Grimbizis G, Haimovich S, Laganà AS, Li TC, Mencaglia L, Rienzi L, Saravelos S, Soares SR, Tanos V, Ubeda A, Ubaldi FM, Van Herendael B, Vereczkey A, Vitagliano A, Vitale SG, Zullo F

Hum Reprod. 2020 Nov 1;35(11):2627-2629. doi: 10.1093/humrep/deaa230.. 2020 doi:

Similar miRNomic signatures characterize the follicular fluids collected after follicular and luteal phase stimulations in the same ovarian cycle.
Cimadomo D, Carmelo R, Parrotta EI, Scalise S, Santamaria G, Alviggi E, De Angelis MT, Sarro G, Vaiarelli A, Venturella R, Rienzi L, Zullo F, Ubaldi FM, Cuda G

.J Assist Reprod Genet. 2020 Jan;37(1):149-158. doi: 10.1007/s10815-019-01607-6. Epub 2019 Nov 7. . 2020 doi:

The dawn of the future: 30 years from the first biopsy of a human embryo. The detailed history of an ongoing revolution.
Cimadomo D, Rienzi L, Capalbo A, Rubio C, Innocenti F, García-Pascual CM, Ubaldi FM, Handyside A

Hum Reprod Update. 2020 Jun 18;26(4):453-473. doi: 10.1093/humupd/dmaa019.. 2020 doi:

The effect of ICSI-related procedural timings and operators on the outcome.
Maggiulli R, Cimadomo D, Fabozzi G, Papini L, Dovere L, Ubaldi FM, Rienzi L

Hum Reprod. 2020 Jan 1;35(1):32-43. doi: 10.1093/humrep/dez234.. 2020 doi:

The euploid blastocysts obtained after luteal phase stimulation show the same clinical, obstetric and perinatal outcomes as follicular phase stimulation-derived ones: a multicenter study.
Vaiarelli A, Cimadomo D, Alviggi E, Sansone A, Trabucco E, Dusi L, Buffo L, Barnocchi N, Fiorini F, Colamaria S, Giuliani M, Argento C, Rienzi L, Ubaldi FM

Hum Reprod. 2020 Nov 1;35(11):2598-2608. doi: 10.1093/humrep/deaa203.. 2020 doi:

Validation of ART Calculator for Predicting the Number of Metaphase II Oocytes Required for Obtaining at Least One Euploid Blastocyst for Transfer in Couples Undergoing in vitro Fertilization/Intracytoplasmic Sperm Injection.
Esteves SC, Yarali H, Ubaldi FM, Carvalho JF, Bento FC, Vaiarelli A, Cimadomo D, Özbek İY, Polat M, Bozdag G, Rienzi L, Alviggi C

Front Endocrinol (Lausanne). 2020 Jan 24;10:917. doi: 10.3389/fendo.2019.00917. eCollection 2019.. 2020 doi:

Which key performance indicators are most effective in evaluating and managing an in vitro fertilization laboratory?
Fabozzi G, Cimadomo D, Maggiulli R, Vaiarelli A, Ubaldi FM, Rienzi L

Fertil Steril. 2020 Jul;114(1):9-15. doi: 10.1016/j.fertnstert.2020.04.054. Epub 2020 Jun 9. . 2020 doi:

A brief history of oocyte cryopreservation: Arguments and facts.
Iussig B, Maggiulli R, Fabozzi G, Bertelle S, Vaiarelli A, Cimadomo D, Ubaldi FM, Rienzi L

Acta Obstet Gynecol Scand. 2019 May;98(5):550-558. doi: 10.1111/aogs.13569. Epub 2019 Mar 25.. 2019 doi:

Advanced Maternal Age in IVF: Still a Challenge? The Present and the Future of Its Treatment.
Ubaldi FM, Cimadomo D, Vaiarelli A, Fabozzi G, Venturella R, Maggiulli R, Mazzilli R, Ferrero S, Palagiano A, Rienzi L

Front Endocrinol (Lausanne). 2019 Feb 20;10:94. doi: 10.3389/fendo.2019.00094. eCollection 2019.. 2019 doi:

An integrated investigation of oocyte developmental competence: expression of key genes in human cumulus cells, morphokinetics of early divisions, blastulation, and euploidy.
Scarica C, Cimadomo D, Dovere L, Giancani A, Stoppa M, Capalbo A, Ubaldi FM, Rienzi L, Canipari R

J Assist Reprod Genet. 2019 May;36(5):875-887. doi: 10.1007/s10815-019-01410-3. Epub 2019 Feb 1.. 2019 doi:

Contribution of cryopreservation to the cumulative live birth rate: a large multicentric cycle-based data analysis from the Italian National Registry.
Scaravelli G, Levi-Setti PE, Livi C, La Sala G, Ubaldi FM, Greco E, Coccia ME, Borini A, Revelli A, Ricci G, Vigiliano V, De Luca R, Bolli S, Rienzi L, Collaborators

J Assist Reprod Genet. 2019 Nov;36(11):2287-2295. doi: 10.1007/s10815-019-01566-y. Epub 2019 Aug 28.. 2019 doi:

Correction to: Contribution of cryopreservation to the cumulative live birth rate: a large multicentric cycle-based data analysis from the Italian National Registry.
Scaravelli G, Levi-Setti PE, Livi C, La Sala G, Ubaldi FM, Greco E, Coccia ME, Borini A, Revelli A, Ricci G, Vigiliano V, De Luca R, Bolli S, Rienzi L

J Assist Reprod Genet. 2019 Nov;36(11):2297. doi: 10.1007/s10815-019-01581-z.. 2019 doi:

Definition and validation of a custom protocol to detect miRNAs in the spent media after blastocyst culture: searching for biomarkers of implantation.
Cimadomo D, Rienzi L, Giancani A, Alviggi E, Dusi L, Canipari R, Noli L, Ilic D, Khalaf Y, Ubaldi FM, Capalbo A

Hum Reprod. 2019 Sep 29;34(9):1746-1761. doi: 10.1093/humrep/dez119.. 2019 doi:

Double stimulation in the same ovarian cycle (DuoStim) is an intriguing strategy to improve oocyte yield and the number of competent embryos in a short timeframe.
Vaiarelli A, Cimadomo D, Argento C, Ubaldi N, Trabucco E, Drakopoulos P, Venturella R, Conforti A, Alviggi C, Rienzi L, Ubaldi FM

Minerva Ginecol. 2019 Oct;71(5):372-376. doi: 10.23736/S0026-4784.19.04390-9. Epub 2019 Mar 4.. 2019 doi:

How time to healthy singleton delivery could affect decision-making during infertility treatment: a Delphi consensus.
Bosch E, Bulletti C, Copperman AB, Fanchin R, Yarali H, Petta CA, Polyzos NP, Shapiro D, Ubaldi FM, Garcia Velasco JA, Longobardi S, D'Hooghe T, Humaidan P, Delphi TTP Consensus Group

Reprod Biomed Online. 2019 Jan;38(1):118-130. doi: 10.1016/j.rbmo.2018.09.019. Epub 2018 Nov 7.. 2019 doi:

Human Blastocyst Biopsy and Vitrification.
Maggiulli R, Giancani A, Cimadomo D, Ubaldi FM, Rienzi L

J Vis Exp. 2019 Jul 26;(149). doi: 10.3791/59625.. 2019 doi:

Looking past the appearance: a comprehensive description of the clinical contribution of poor-quality blastocysts to increase live birth rates during cycles with aneuploidy testing.
Cimadomo D, Soscia D, Vaiarelli A, Maggiulli R, Capalbo A, Ubaldi FM, Rienzi L

Hum Reprod. 2019 Jul 8;34(7):1206-1214. doi: 10.1093/humrep/dez078.. 2019 doi:

Management of Women With an Unexpected Low Ovarian Response to Gonadotropin.
Conforti A, Esteves SC, Cimadomo D, Vaiarelli A, Di Rella F, Ubaldi FM, Zullo F, De Placido G, Alviggi C

Front Endocrinol (Lausanne). 2019 Jun 27;10:387. doi: 10.3389/fendo.2019.00387. eCollection 2019.. 2019 doi:

Non-invasive mitochondrial DNA quantification on Day 3 predicts blastocyst development: a prospective, blinded, multi-centric study.
Stigliani S, Orlando G, Massarotti C, Casciano I, Bovis F, Anserini P, Ubaldi FM, Remorgida V, Rienzi L, Scaruffi P

Mol Hum Reprod. 2019 Sep 1;25(9):527-537. doi: 10.1093/molehr/gaz032.. 2019 doi:

Oocyte quantity, as well as oocyte quality, plays a significant role for the cumulative live birth rate of a POSEIDON criteria patient.
Esteves SC, Roque M, Sunkara SK, Conforti A, Ubaldi FM, Humaidan P, Alviggi C

Hum Reprod. 2019 Dec 1;34(12):2555-2557. doi: 10.1093/humrep/dez181.. 2019 doi:

Perspectives in Gamete and Embryo Cryopreservation.
Rienzi LF, Iussig B, Dovere L, Fabozzi G, Cimadomo D, Ubaldi FM

Semin Reprod Med. 2018 Sep;36(5):253-264. doi: 10.1055/s-0038-1677463. Epub 2019 Apr 4. . 2019 doi:

Pharmacogenetics of FSH Action in the Female.
Conforti A, Vaiarelli A, Cimadomo D, Bagnulo F, Peluso S, Carbone L, Di Rella F, De Placido G, Ubaldi FM, Huhtaniemi I, Alviggi C

Front Endocrinol (Lausanne). 2019 Jun 26;10:398. doi: 10.3389/fendo.2019.00398. eCollection 2019.. 2019 doi:

Sperm DNA fragmentation to predict embryo development, implantation, and miscarriage: still an open question.
Rienzi L, Mazzilli R, Ubaldi FM

Fertil Steril. 2019 Sep;112(3):466. doi: 10.1016/j.fertnstert.2019.05.016. Epub 2019 Jul 1.. 2019 doi:

State of the art and emerging drug therapies for female infertility.
Venturella R, Vaiarelli A, Cimadomo D, Pedri S, Lico D, Mazzilli R, Mocciaro R, Rienzi L, Di Carlo C, Ubaldi FM, Zullo F

Gynecol Endocrinol. 2019 Oct;35(10):835-841. doi: 10.1080/09513590.2019.1603289. Epub 2019 Apr 29.. 2019 doi:

The main will of the patients of a private Italian IVF clinic for their aneuploid/affected blastocysts would be donation to research: a currently forbidden choice.
Faustini F, Forte M, Capalbo A, Cimadomo D, Ubaldi FM, Rienzi L

J Assist Reprod Genet. 2019 Aug;36(8):1555-1560. doi: 10.1007/s10815-019-01465-2. Epub 2019 May 27.. 2019 doi:

The POSEIDON Criteria and Its Measure of Success Through the Eyes of Clinicians and Embryologists.
Esteves SC, Alviggi C, Humaidan P, Fischer R, Andersen CY, Conforti A, Bühler K, Sunkara SK, Polyzos NP, Galliano D, Grynberg M, Yarali H, Özbek IY, Roque M, Vuong LN, Banker M, Rienzi L, Vaiarelli A, Cimadomo D, Ubaldi FM

Front Endocrinol (Lausanne). 2019 Nov 20;10:814. doi: 10.3389/fendo.2019.00814. eCollection 2019.. 2019 doi:

Time of morulation and trophectoderm quality are predictors of a live birth after euploid blastocyst transfer: a multicenter study.
Rienzi L, Cimadomo D, Delgado A, Minasi MG, Fabozzi G, Gallego RD, Stoppa M, Bellver J, Giancani A, Esbert M, Capalbo A, Remohì J, Greco E, Ubaldi FM, Meseguer M

Fertil Steril. 2019 Dec;112(6):1080-1093.e1. doi: 10.1016/j.fertnstert.2019.07.1322.. 2019 doi:

A modern approach to the management of candidates for assisted reproductive technology procedures.
Venturella R, Vaiarelli A, Lico D, Ubaldi FM, Zullo F, DI Carlo C

Minerva Ginecol. 2018 Feb;70(1):69-83. doi: 10.23736/S0026-4784.17.04138-7. Epub 2017 Sep 12.. 2018 doi:

Associations of blastocyst features, trophectoderm biopsy and other laboratory practice with post-warming behavior and implantation.
Cimadomo D, Capalbo A, Levi-Setti PE, Soscia D, Orlando G, Albani E, Parini V, Stoppa M, Dovere L, Tacconi L, Ievoli E, Maggiulli R, Ubaldi FM, Rienzi L

Hum Reprod. 2018 Nov 1;33(11):1992-2001. doi: 10.1093/humrep/dey291.. 2018 doi:

Biochemical pregnancy loss after frozen embryo transfer seems independent of embryo developmental stage and chromosomal status.
Vaiarelli A, Cimadomo D, Patrizio P, Venturella R, Orlando G, Soscia D, Giancani A, Capalbo A, Rienzi L, Ubaldi FM

Reprod Biomed Online. 2018 Sep;37(3):349-357. doi: 10.1016/j.rbmo.2018.05.019. Epub 2018 Jun 30.. 2018 doi:

Continuous embryo culture elicits higher blastulation but similar cumulative delivery rates than sequential: a large prospective study.
Cimadomo D, Scarica C, Maggiulli R, Orlando G, Soscia D, Albricci L, Romano S, Sanges F, Ubaldi FM, Rienzi L

J Assist Reprod Genet. 2018 Jul;35(7):1329-1338. doi: 10.1007/s10815-018-1195-4. Epub 2018 May 3.. 2018 doi:

Diagnostic efficacy of blastocoel fluid and spent media as sources of DNA for preimplantation genetic testing in standard clinical conditions.
Capalbo A, Romanelli V, Patassini C, Poli M, Girardi L, Giancani A, Stoppa M, Cimadomo D, Ubaldi FM, Rienzi L

Fertil Steril. 2018 Oct;110(5):870-879.e5. doi: 10.1016/j.fertnstert.2018.05.031.. 2018 doi:

Double Stimulation in the Same Ovarian Cycle (DuoStim) to Maximize the Number of Oocytes Retrieved From Poor Prognosis Patients: A Multicenter Experience and SWOT Analysis.
Vaiarelli A, Cimadomo D, Trabucco E, Vallefuoco R, Buffo L, Dusi L, Fiorini F, Barnocchi N, Bulletti FM, Rienzi L, Ubaldi FM

Front Endocrinol (Lausanne). 2018 Jun 14;9:317. doi: 10.3389/fendo.2018.00317. eCollection 2018.. 2018 doi:

Impact of Maternal Age on Oocyte and Embryo Competence.
Cimadomo D, Fabozzi G, Vaiarelli A, Ubaldi N, Ubaldi FM, Rienzi L

Front Endocrinol (Lausanne). 2018 Jun 29;9:327. doi: 10.3389/fendo.2018.00327. eCollection 2018.. 2018 doi:

Inconclusive chromosomal assessment after blastocyst biopsy: prevalence, causative factors and outcomes after re-biopsy and re-vitrification. A multicenter experience.
Cimadomo D, Rienzi L, Romanelli V, Alviggi E, Levi-Setti PE, Albani E, Dusi L, Papini L, Livi C, Benini F, Smeraldi A, Patassini C, Ubaldi FM, Capalbo A

Hum Reprod. 2018 Oct 1;33(10):1839-1846. doi: 10.1093/humrep/dey282.. 2018 doi:

Luteal phase anovulatory follicles result in the production of competent oocytes: intra-patient paired case-control study comparing follicular versus luteal phase stimulations in the same ovarian cycle.
Cimadomo D, Vaiarelli A, Colamaria S, Trabucco E, Alviggi C, Venturella R, Alviggi E, Carmelo R, Rienzi L, Ubaldi FM

Hum Reprod. 2018 Aug 1;33(8):1442-1448. doi: 10.1093/humrep/dey217.. 2018 doi:

Prevalence of XXY karyotypes in human blastocysts: multicentre data from 7549 trophectoderm biopsies obtained during preimplantation genetic testing cycles in IVF.
Mazzilli R, Cimadomo D, Rienzi L, Capalbo A, Levi Setti PE, Livi C, Vizziello D, Foresta C, Ferlin A, Ubaldi FM

Hum Reprod. 2018 Jul 1;33(7):1355-1363. doi: 10.1093/humrep/dey110.. 2018 doi:

Progesterone for preparation of the endometrium for frozen-thawed blastocyst transfer in vitro fertilization cycles: a prospective study on patients' opinions on a new subcutaneous formulation.
Venturella R, Vaiarelli A, Buffo L, D'alessandro P, Colamaria S, Pedri S, Di Carlo C, Alviggi E, Forte M, Faustini F, Zullo F, Rienzi L, Ubaldi FM

Gynecol Endocrinol. 2018 Sep;34(9):766-771. doi: 10.1080/09513590.2018.1451508. Epub 2018 Mar 16.. 2018 doi:

What is new in the management of poor ovarian response in IVF?
Vaiarelli A, Cimadomo D, Ubaldi N, Rienzi L, Ubaldi FM

Curr Opin Obstet Gynecol. 2018 Jun;30(3):155-162. doi: 10.1097/GCO.0000000000000452.. 2018 doi:

Abnormally fertilized oocytes can result in healthy live births: improved genetic technologies for preimplantation genetic testing can be used to rescue viable embryos in in vitro fertilization cycles.
Capalbo A, Treff N, Cimadomo D, Tao X, Ferrero S, Vaiarelli A, Colamaria S, Maggiulli R, Orlando G, Scarica C, Scott R, Ubaldi FM, Rienzi L

Fertil Steril. 2017 Dec;108(6):1007-1015.e3. doi: 10.1016/j.fertnstert.2017.08.004. Epub 2017 Sep 15.. 2017 doi:

Detecting mosaicism in trophectoderm biopsies: current challenges and future possibilities.
Capalbo A, Ubaldi FM, Rienzi L, Scott R, Treff N

Hum Reprod. 2017 Mar 1;32(3):492-498. doi: 10.1093/humrep/dew250.. 2017 doi:

Diagnosis and clinical management of duplications and deletions.
Capalbo A, Rienzi L, Ubaldi FM

Fertil Steril. 2017 Jan;107(1):12-18. doi: 10.1016/j.fertnstert.2016.11.002.. 2017 doi:

Dual ovarian stimulation and random start in assisted reproductive technologies: from ovarian biology to clinical application.
Vaiarelli A, Venturella R, Vizziello D, Bulletti F, Ubaldi FM

Curr Opin Obstet Gynecol. 2017 Jun;29(3):153-159. doi: 10.1097/GCO.0000000000000365.. 2017 doi:

Effect of the male factor on the clinical outcome of intracytoplasmic sperm injection combined with preimplantation aneuploidy testing: observational longitudinal cohort study of 1,219 consecutive cycles.
Mazzilli R, Cimadomo D, Vaiarelli A, Capalbo A, Dovere L, Alviggi E, Dusi L, Foresta C, Lombardo F, Lenzi A, Tournaye H, Alviggi C, Rienzi L, Ubaldi FM

Fertil Steril. 2017 Dec;108(6):961-972.e3. doi: 10.1016/j.fertnstert.2017.08.033. Epub 2017 Oct 3.. 2017 doi:

Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging.
Capalbo A, Hoffmann ER, Cimadomo D, Ubaldi FM, Rienzi L

Hum Reprod Update. 2017 Nov 1;23(6):706-722. doi: 10.1093/humupd/dmx026.. 2017 doi:

Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance.
Rienzi L, Gracia C, Maggiulli R, LaBarbera AR, Kaser DJ, Ubaldi FM, Vanderpoel S, Racowsky C

Hum Reprod Update. 2017 Mar 1;23(2):139-155. doi: 10.1093/humupd/dmw038. . 2017 doi:

PGS for recurrent pregnancy loss: still an open question.
Rienzi L, Capalbo A, Vajta G, Ubaldi FM

Hum Reprod. 2017 Feb;32(2):476-477. doi: 10.1093/humrep/dew311. Epub 2016 Dec 13.. 2017 doi:

Preimplantation genetic diagnosis for aneuploidy testing in women older than 44 years: a multicenter experience.
Ubaldi FM, Cimadomo D, Capalbo A, Vaiarelli A, Buffo L, Trabucco E, Ferrero S, Albani E, Rienzi L, Levi Setti PE

Fertil Steril. 2017 May;107(5):1173-1180. doi: 10.1016/j.fertnstert.2017.03.007. Epub 2017 Apr 19.. 2017 doi:

45,X product of conception after preimplantation genetic diagnosis and euploid embryo transfer: evidence of a spontaneous conception confirmed by DNA fingerprinting.
Bettio D, Capalbo A, Albani E, Rienzi L, Achille V, Venci A, Ubaldi FM, Levi Setti PE

Reprod Biol Endocrinol. 2016 Sep 6;14(1):55. doi: 10.1186/s12958-016-0190-9.. 2016 doi:

5,X product of conception after preimplantation genetic diagnosis and euploid embryo transfer: evidence of a spontaneous conception confirmed by DNA fingerprinting.
Bettio D, Capalbo A, Albani E, Rienzi L, Achille V, Venci A, Ubaldi FM, Levi Setti PE

Reprod Biol Endocrinol. 2016 Sep 6;14(1):55. doi: 10.1186/s12958-016-0190-9.. 2016 doi:

A new more detailed stratification of low responders to ovarian stimulation: from a poor ovarian response to a low prognosis concept.
Poseidon Group (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number), Alviggi C, Andersen CY, Buehler K, Conforti A, De Placido G, Esteves SC, Fischer R, Galliano D, Polyzos NP, Sunkara SK, Ubaldi FM, Humaidan P

Fertil Steril. 2016 Jun;105(6):1452-3. doi: 10.1016/j.fertnstert.2016.02.005. Epub 2016 Feb 26.. 2016 doi:

Artificial oocyte activation with calcium ionophore does not cause a widespread increase in chromosome segregation errors in the second meiotic division of the oocyte.
Capalbo A, Ottolini CS, Griffin DK, Ubaldi FM, Handyside AH, Rienzi L

Fertil Steril. 2016 Mar;105(3):807-814.e2. doi: 10.1016/j.fertnstert.2015.11.017. Epub 2015 Dec 1.. 2016 doi:

Cancer and fertility preservation: international recommendations from an expert meeting.
Lambertini M, Del Mastro L, Pescio MC, Andersen CY, Azim HA Jr, Peccatori FA, Costa M, Revelli A, Salvagno F, Gennari A, Ubaldi FM, La Sala GB, De Stefano C, Wallace WH, Partridge AH, Anserini P

BMC Med. 2016 Jan 4;14:1. doi: 10.1186/s12916-015-0545-7. . 2016 doi:

Consistent and reproducible outcomes of blastocyst biopsy and aneuploidy screening across different biopsy practitioners: a multicentre study involving 2586 embryo biopsies.
Capalbo A, Ubaldi FM, Cimadomo D, Maggiulli R, Patassini C, Dusi L, Sanges F, Buffo L, Venturella R, Rienzi L

Hum Reprod. 2016 Jan;31(1):199-208. doi: 10.1093/humrep/dev294. Epub 2015 Dec 4.. 2016 doi:

Early protein profile of human embryonic secretome.
Foresta C, Ubaldi FM, Rienzi L, Franchin C, Pivato M, Romano S, Guidolin D, De Caro R, Ferlin A, De Toni L

Front Biosci (Landmark Ed). 2016 Jan 1;21(3):620-34. doi: 10.2741/4410.. 2016 doi:

Electronic witness system in IVF-patients perspective.
Forte M, Faustini F, Maggiulli R, Scarica C, Romano S, Ottolini C, Farcomeni A, Palagiano A, Capalbo A, Ubaldi FM, Rienzi L

J Assist Reprod Genet. 2016 Sep;33(9):1215-22. doi: 10.1007/s10815-016-0759-4. Epub 2016 Jul 7.. 2016 doi:

Failure mode and effects analysis of witnessing protocols for ensuring traceability during PGD/PGS cycles.
Cimadomo D, Ubaldi FM, Capalbo A, Maggiulli R, Scarica C, Romano S, Poggiana C, Zuccarello D, Giancani A, Vaiarelli A, Rienzi L

Reprod Biomed Online. 2016 Sep;33(3):360-9. doi: 10.1016/j.rbmo.2016.06.002. Epub 2016 Jun 23.. 2016 doi:

Follicular versus luteal phase ovarian stimulation during the same menstrual cycle (DuoStim) in a reduced ovarian reserve population results in a similar euploid blastocyst formation rate: new insight in ovarian reserve exploitation.
Ubaldi FM, Capalbo A, Vaiarelli A, Cimadomo D, Colamaria S, Alviggi C, Trabucco E, Venturella R, Vajta G, Rienzi L

Fertil Steril. 2016 Jun;105(6):1488-1495.e1. doi: 10.1016/j.fertnstert.2016.03.002. Epub 2016 Mar 25.. 2016 doi:

Generation of meiomaps of genome-wide recombination and chromosome segregation in human oocytes.
Ottolini CS, Capalbo A, Newnham L, Cimadomo D, Natesan SA, Hoffmann ER, Ubaldi FM, Rienzi L, Handyside AH

Nat Protoc. 2016 Jul;11(7):1229-43. doi: 10.1038/nprot.2016.075. Epub 2016 Jun 16.. 2016 doi:

Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c.
Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D

Stem Cells Dev. 2016 Dec 15;25(24):1853-1862. doi: 10.1089/scd.2016.0212. Epub 2016 Oct 17.. 2016 doi:

Implementing PGD/PGD-A in IVF clinics: considerations for the best laboratory approach and management.
Capalbo A, Romanelli V, Cimadomo D, Girardi L, Stoppa M, Dovere L, Dell'Edera D, Ubaldi FM, Rienzi L

J Assist Reprod Genet. 2016 Oct;33(10):1279-1286. doi: 10.1007/s10815-016-0768-3. Epub 2016 Jul 16. . 2016 doi:

MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells and can be explored for human embryo reproductive competence assessment.
Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L

Fertil Steril. 2016 Jan;105(1):225-35.e1-3. doi: 10.1016/j.fertnstert.2015.09.014. Epub 2015 Oct 9.. 2016 doi:

New approaches for multifactor preimplantation genetic diagnosis of monogenic diseases and aneuploidies from a single biopsy.
Capalbo A, Rienzi L, Ubaldi FM

Fertil Steril. 2016 Feb;105(2):297-8. doi: 10.1016/j.fertnstert.2015.10.039. Epub 2015 Nov 21.. 2016 doi:

Pre-implantation genetic testing in ART: who will benefit and what is the evidence?
Vaiarelli A, Cimadomo D, Capalbo A, Orlando G, Sapienza F, Colamaria S, Palagiano A, Bulletti C, Rienzi L, Ubaldi FM

.J Assist Reprod Genet. 2016 Oct;33(10):1273-1278. doi: 10.1007/s10815-016-0785-2. Epub 2016 Aug 5.. 2016 doi:

The Impact of Biopsy on Human Embryo Developmental Potential during Preimplantation Genetic Diagnosis.
Cimadomo D, Capalbo A, Ubaldi FM, Scarica C, Palagiano A, Canipari R, Rienzi L

Biomed Res Int. 2016;2016:7193075. doi: 10.1155/2016/7193075. Epub 2016 Jan 28.. 2016 doi:

The use of ovarian reserve markers in IVF clinical practice: a national consensus.
La Marca A, Ferraretti AP, Palermo R, Ubaldi FM

Gynecol Endocrinol. 2016;32(1):1-5. doi: 10.3109/09513590.2015.1102879. Epub 2015 Nov 4.. 2016 doi:

Comparison of array comparative genomic hybridization and quantitative real-time PCR-based aneuploidy screening of blastocyst biopsies.
Capalbo A, Treff NR, Cimadomo D, Tao X, Upham K, Ubaldi FM, Rienzi L, Scott RT Jr

Eur J Hum Genet. 2015 Jul;23(7):901-6. doi: 10.1038/ejhg.2014.222. Epub 2014 Oct 29.. 2015 doi:

Developmental clock compromises human twin model created by embryo splitting.
Noli L, Dajani Y, Capalbo A, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D

Hum Reprod. 2015 Dec;30(12):2774-84. doi: 10.1093/humrep/dev252. Epub 2015 Oct 21. . 2015 doi:

Failure mode and effects analysis of witnessing protocols for ensuring traceability during IVF.
Rienzi L, Bariani F, Dalla Zorza M, Romano S, Scarica C, Maggiulli R, Nanni Costa A, Ubaldi FM

Reprod Biomed Online. 2015 Oct;31(4):516-22. doi: 10.1016/j.rbmo.2015.06.018. Epub 2015 Jul 7.. 2015 doi:

Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates.
Ottolini CS, Newnham L, Capalbo A, Natesan SA, Joshi HA, Cimadomo D, Griffin DK, Sage K, Summers MC, Thornhill AR, Housworth E, Herbert AD, Rienzi L, Ubaldi FM, Handyside AH, Hoffmann ER

Nat Genet. 2015 Jul;47(7):727-735. doi: 10.1038/ng.3306. Epub 2015 May 18.. 2015 doi:

Loop electrosurgical excision procedure: a risk for spontaneous abortion?
Ubaldi FM, Vaiarelli A, Rienzi L

.Fertil Steril. 2015 Apr;103(4):904-5. doi: 10.1016/j.fertnstert.2015.01.016. Epub 2015 Feb 3.. 2015 doi:

No evidence of association between blastocyst aneuploidy and morphokinetic assessment in a selected population of poor-prognosis patients: a longitudinal cohort study.
Rienzi L, Capalbo A, Stoppa M, Romano S, Maggiulli R, Albricci L, Scarica C, Farcomeni A, Vajta G, Ubaldi FM

Reprod Biomed Online. 2015 Jan;30(1):57-66. doi: 10.1016/j.rbmo.2014.09.012. Epub 2014 Oct 5.. 2015 doi:

Oocyte versus embryo cryopreservation for fertility preservation in cancer patients: guaranteeing a women's autonomy.
Rienzi L, Ubaldi FM

J Assist Reprod Genet. 2015 Aug;32(8):1195-6. doi: 10.1007/s10815-015-0507-1. Epub 2015 Jun 17.. 2015 doi:

Open versus closed systems for vitrification of human oocytes and embryos.
Vajta G, Rienzi L, Ubaldi FM

Reprod Biomed Online. 2015 Apr;30(4):325-33. doi: 10.1016/j.rbmo.2014.12.012. Epub 2015 Jan 12.. 2015 doi:

Reduction of multiple pregnancies in the advanced maternal age population after implementation of an elective single embryo transfer policy coupled with enhanced embryo selection: pre- and post-intervention study.
Ubaldi FM, Capalbo A, Colamaria S, Ferrero S, Maggiulli R, Vajta G, Sapienza F, Cimadomo D, Giuliani M, Gravotta E, Vaiarelli A, Rienzi L

Hum Reprod. 2015 Sep;30(9):2097-106. doi: 10.1093/humrep/dev159. Epub 2015 Jul 5.. 2015 doi:

Correlation between standard blastocyst morphology, euploidy and implantation: an observational study in two centers involving 956 screened blastocysts.
Capalbo A, Rienzi L, Cimadomo D, Maggiulli R, Elliott T, Wright G, Nagy ZP, Ubaldi FM

Hum Reprod. 2014 Jun;29(6):1173-81. doi: 10.1093/humrep/deu033. Epub 2014 Feb 26.. 2014 doi:

FISH reanalysis of inner cell mass and trophectoderm samples of previously array-CGH screened blastocysts shows high accuracy of diagnosis and no major diagnostic impact of mosaicism at the blastocyst stage.
Capalbo A, Wright G, Elliott T, Ubaldi FM, Rienzi L, Nagy ZP

Hum Reprod. 2013 Aug;28(8):2298-307. doi: 10.1093/humrep/det245. Epub 2013 Jun 5.. 2013 doi:

Reply: Questions about the accuracy of polar body analysis for preimplantation genetic screening.
Capalbo A, Bono S, Spizzichino L, Biricik A, Baldi M, Colamaria S, Ubaldi FM, Rienzi L, Fiorentino F

Hum Reprod. 2013 Jun;28(6):1733-6. doi: 10.1093/humrep/det070. Epub 2013 Mar 26.. 2013 doi:

Sequential comprehensive chromosome analysis on polar bodies, blastomeres and trophoblast: insights into female meiotic errors and chromosomal segregation in the preimplantation window of embryo development.
Capalbo A, Bono S, Spizzichino L, Biricik A, Baldi M, Colamaria S, Ubaldi FM, Rienzi L, Fiorentino F

Hum Reprod. 2013 Feb;28(2):509-18. doi: 10.1093/humrep/des394. Epub 2012 Nov 11.. 2013 doi:

Consistent and predictable delivery rates after oocyte vitrification: an observational longitudinal cohort multicentric study.
Rienzi L, Cobo A, Paffoni A, Scarduelli C, Capalbo A, Vajta G, Remohí J, Ragni G, Ubaldi FM

Hum Reprod. 2012 Jun;27(6):1606-12. doi: 10.1093/humrep/des088. Epub 2012 Mar 22.. 2012 doi:

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