Marcos Meseguer, Ph.D.

Scientific Supervisor and Senior Embryologist at the IVI Valencia IVF unit

IVI Valencia

Marcos Meseguer, Ph.D.

Biography

Dr. Marcos Meseguer received his B.Sc. degree in Biological Sciences from the University of Valencia in Spain. He then performed a pre-doctoral fellowship in St Mary´s Hospital, Manchester University, United Kingdom, and received his Ph.D. Degree in Obstetrics and Gynecoloy and the European Doctor Degree in 2002 from the University of Valencia, Spain. He has also a master degree in Research Methods; Design and Statistics from Universidad Autónoma de Barcelona, Spain.
Dr.Meseguer is currently the Scientific Supervisor and Senior Embryologist at the IVI Valencia IVF unit. Previously, he was co-Director of the Andrology Laboratory at the Instituto Valenciano de Infertilidad (IVI).

Dr. Meseguer has received the Prize Paper Award of the American Society of Reproductive Medicine, three times the Lalor Foundation International Award from the American Society of Andrology, three times the research award from the Spanish Society of Fertility and four times the research award from the Spanish Society of Embrology. He received the Robert Edwards prize paper award from RBM online and is ASRM star award winner. The primary areas of his research are embryology and male infertility.
As Principal Investigator, his work has been funded through 16 projects sponsored by the Spanish Government, including five EUREKA projects (granted to high quality technological projects) supported by the European Community. He has one international patent.
He has published over 145 scientific articles, with 5400 citations and h-index of 43, including the most cited paper in Human Reproduction during 2013. Additionally published 50 reviews or book chapters, edited the first time-lapse book and made more than 500 presentations at national and international congresses. He has been the Director of 13 Doctoral Thesis all qualified with “Cum Laude”, and currently is directing 6 PhD candidates. In addition, he is also Statistics Advisor of Equipo IVI and Associate Professor of the Master’s in Biotechnology at University of Valencia.


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Education and Training

BS University of Valencia (1998)
PhD in Obstetrics and Gynecology University of Valencia (2002)
European Doctor Degree in Biological Sciences University of Valencia (2002)
Master Statistics and Research Methods University of Barcelona (2009)

Honors and recognition

Honorable Member Spanish Society of Embryology 2017
ASRM star award winner 2017
Research award from the Spanish Society of Embryology 2015
Robert Edwards prize paper award from RBM online 2014
Spanish Society of Fertility Research Award 2014
Research award from the Spanish Society of Embryology 2013
Spanish Society of Fertility Research Award 2012
Research award from the Spanish Society of Embryology 2011
Research award from the Spanish Society of Embryology 2009
Lalor Foundation International Award from the American Society of Andrology 2008
Lalor Foundation International Award from the American Society of Andrology 2005
Lalor Foundation International Award from the American Society of Andrology 2003
Prize paper Journal of Spanish Society of Fertility 2002

Publications


  • The latest attempt to improve the sperm's path.
    Meseguer M, Pellicer A. What else can we do?
    Fertil Steril, 108:444-445, 2017.

  • The evolution of embryo morphokinetics.
    Meseguer M, Pellicer A. One for all or all for one?
    Fertil Steril, 107:571-572, 2017.

  • Study of nucleation status in the second cell cycle of human embryo and its impact on implantation rate.
    Aguilar J, Rubio I, Muñoz E, Pellicer A, Meseguer M.
    Fertil Steril, 106:291-299.e2, 2016.

  • Automatic time-lapse instrument is superior to single-point morphology observation for selecting viable embryos: retrospective study in oocyte donation.
    Aparicio-Ruiz B, Basile N, Pérez Albalá S, Bronet F, Remohí J, Meseguer M.
    Fertil Steril, 106:1379-1385.e10, 2016.

  • How much have we learned from time-lapse in clinical IVF?
    Castelló D, Motato Y, Basile N, Remohí J, Espejo-Catena M, Meseguer M.
    Mol Hum Reprod, 22:719-727, 2016.

  • A combination of hydroxypropyl cellulose and trehalose as supplementation for vitrification of human oocytes: a retrospective cohort study.
    Coello A, Campos P, Remohí J, Meseguer M, Cobo A.
    J Assist Reprod Genet, 33:413-421, 2016.

  • Blastocyst development in single medium with or without renewal on day 3: a prospective cohort study on sibling donor oocytes in a time-lapse incubator.
    Costa-Borges N, Bellés M, Meseguer M, Galliano D, Ballesteros A, Calderón G
    Fertil Steril, 105:707-713, 2016.

  • Examining potential reasons why euploid blastocysts do not always implant. Part 1. Optimizing the culture environment and embryo manipulation to maintain viability.
    Swain J, Carrell D, Cobo A, Meseguer M, Rubio C, Smith G.
    Fertil Steril, 105: 571-87, 2016.

  • Time-lapse: the remaining questions to be answered.
    Meseguer M.
    Fertil Steril, 105:295-296, 2016.

  • Morphokinetic analysis and embryonic prediction for blastocyst formation through an integrated time-lapse system.
    Motato Y, de los Santos MJ, Escriba MJ, Ruiz BA, Remohí J, Meseguer M.
    Fertil Steril, 105:376-384.e9, 2016.

  • Obstetric and perinatal outcome of babies born from sperm selected by MACS from a randomized controlled trial.
    Romany L, Garrido N, Cobo A, Aparicio-Ruiz B, Serra V, Meseguer M.
    J Assist Reprod Genet, 34:201-207, 2016.

  • The why, the how and the when of PGS 2.0: current practices and expert opinions of fertility specialists, molecular biologists, and embryologists.
    Sermon K, Capalbo A, Cohen J, Coonen E, De Rycke M, De Vos A, Delhanty J, Fiorentino F, Gleicher N, Griesinger G, Grifo J, Handyside A, Harper J, Kokkali G, Mastenbroek S, Meldrum D, Meseguer M, Montag M, Munné S, Rienzi L, Rubio C, Scott K, Scott R, Simon C, Swain J, Treff N, Ubaldi F, Vassena R, Vermeesch JR, Verpoest W, Wells D, Geraedts J.
    Mol Hum Reprod, 22:845-857, 2016.

  • Combination of metabolism measurement and a time-lapse system provides an embryo selection method based on oxygen uptake and chronology of cytokinesis timing.
    Tejera A, Castelló D, de los Santos JM, Pellicer A, Remohí J, Meseguer M.
    Fertil Steril, 106:119-126.e2, 2016.

  • Time-lapse in the IVF lab: how should we assess potential benefit?
    Basile N, Barriere P, Meseguer M, Freour T.
    Hum Reprod, 30:1276-1276, 2015.

  • What does morphokinetics add to embryo selection and in-vitro fertilization outcomes?
    Basile N, Caiazzo M, Meseguer M.
    Curr Opin Obstet Gynecol, 27:193-200, 2015.

  • Is there a relationship between time-lapse parameters and embryo sex?
    Bronet F, Nogales M-C, Martínez E, Ariza M, Rubio C, García-Velasco J-A, Meseguer M.
    Fertil Steril, 103:396-401.e2, 2015.

  • New strategy for diagnosing embryo implantation potential by combining proteomics and time-lapse technologies.
    Dominguez F, Meseguer M, Aparicio-Ruiz B, Piqueras P, Quiñonero A, Simón C.
    Fertil Steril, 104:908-914, 2015.

  • Diagnosis of human preimplantation embryo viability.
    Gardner DK, Meseguer M, Rubio C, Treff NR.
    Hum Reprod Update, 21:727-747, 2015.

  • Morphokinetics as a predictor of self-correction to diploidy in tripronucleated intracytoplasmic sperm injection–derived human embryos.
    Grau N, Escrich L, Galiana Y, Meseguer M, García-Herrero S, Remohí J, Escribá M-J.
    Fertil Steril, 104:728-735, 2015.

  • Collapse of blastocysts is strongly related to lower implantation success: a time-lapse study.
    Marcos J, Pérez-Albalá S, Mifsud A, Molla M, Landeras J, Meseguer M.
    Hum Reprod, 30:2501-2508, 2015.

  • La tecnología del Time-lapse y su aplicación en las clínicas de reproducción asistida.
    Meseguer M, Motato M.
    ASEBIR, 20: 47-52, 2015.

  • The human first cell cycle: impact on implantation.
    Aguilar J, Motato Y, Escribá MJ, Ojeda M, Muñoz E, Meseguer M.
    Reprod Biomed Online, 28:475-484, 2014.

  • Increasing the probability of selecting chromosomally normal embryos by time-lapse morphokinetics analysis.
    Basile N, Nogales MdC, Bronet F, Florensa M, Riqueiros M, Rodrigo L, García-Velasco J, Meseguer M.
    Fertil Steril, 101:699-704.e1, 2014.

  • The use of morphokinetics as a predictor of  implantation: a multicentric study to define and validate an algorithm for embryo selection.
    Basile N, Vime P, Florensa M, Aparicio Ruiz B, García Velasco JA, Remohí J, Meseguer M.
    Hum Reprod, 30:276-283, 2014.

  • Systematic review on clinical outcomes following selection of human preimplantation embryos with time-lapse monitoring.
    Freour T, Basile N, Barriere P, Meseguer M.
    Hum Reprod Update, 21:153-154, 2014.

  • Ethnicity as a determinant of ovarian reserve: differences in ovarian aging between Spanish and Indian women.
    Iglesias C, Banker M, Mahajan N, Herrero L, Meseguer M, Garcia-Velasco JA
    Fertil Steril, 102:244-249, 2014.

  • High progesterone levels in women with high ovarian response do not affect clinical outcomes: a retrospective cohort study.
    Requena A, Cruz M, Bosch E, Meseguer M, García-Velasco J.
    Reprod Biol Endocrinol, 12:69, 2014.

  • Removal of annexin V–positive sperm cells for intracytoplasmic sperm injection in ovum donation cycles does not improve reproductive outcome: a controlled and randomized trial in unselected males.
    Romany L, Garrido N, Motato Y, Aparicio B, Remohí J, Meseguer M.
    Fertil Steril, 102:1567-1575.e1, 2014.

  • Clinical validation of embryo culture and selection by morphokinetic analysis: a randomized, controlled trial of the EmbryoScope.
    Rubio I, Galán A, Larreategui Z, Ayerdi F, Bellver J, Herrero J, Meseguer M
    Fertil Steril, 102:1287-1294.e5, 2014.

  • Is morphokinetic analysis the answer?
    Aparicio B, Cruz M, Meseguer M.
    Reprod Biomed Online, 27:654-663, 2013.

  • Type of culture media does not affect embryo kinetics: a time-lapse analysis of sibling oocytes.
    Basile N, Morbeck D, Garcia-Velasco J, Bronet F, Meseguer M.
    Hum Reprod, 28:634-641, 2013.

  • Similar morphokinetic patterns in embryos derived from obese and normoweight infertile women: a time-lapse study.
    Bellver J, Mifsud A, Grau N, Privitera L, Meseguer M.
    Hum Reprod, 28:794-800, 2013.

  • Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors.
    Bellver J, Pellicer A, García-Velasco JA, Ballesteros A, Remohí J, Meseguer M.
    Fertil Steril, 100:1050-1058.e2, 2013.

  • Oocyte insemination techniques are related to alterations of embryo developmental timing in an oocyte donation model.
    Cruz M, Garrido N, Gadea B, Muñoz M, Pérez-Cano I, Meseguer M.
    Reprod Biomed Online, 27:367-375, 2013.

  • Assessment of sperm using mRNA microarray technology.
    Garrido N, García-Herrero S, Meseguer M.
    Fertil Steril, 99:1008-1022, 2013.

  • Selection of high potential embryos using time-lapse imaging: the era of morphokinetics.
    Herrero J, Meseguer M.
    Fertil Steril, 99:1030-1034, 2013.

  • A time to look back: analysis of morphokinetic characteristics of human embryo development.
    Herrero J, Tejera A, Albert C, Vidal C, de los Santos MJ, Meseguer M.
    Fertil Steril, 100:1602-1609.e4, 2013.

  • The type of GnRH analogue used during controlled ovarian stimulation influences early embryo developmental kinetics: a time-lapse study.
    Muñoz M, Cruz M, Humaidan P, Garrido N, Pérez-Cano I, Meseguer M
    Eur J Obstet Gynecol Reprod Biol, 168:167-172, 2013.

  • PGE2and PGF2α Concentrations in Human Endometrial Fluid as Biomarkers for Embryonic Implantation.
    Vilella F, Ramirez L, Berlanga O, Martínez S, Alamá P, Meseguer M, Pellicer A, Simón C.
    J Clin Endocrinol Metab , 98:4123-4132, 2013.

  • Time-lapse technology: evaluation of embryo quality and new markers for embryo selection.
    Basile N, Meseguer M.
    Expert Rev Obstet Gynecol, 7:175-190, 2012.

  • Timing of cell division in human cleavage-stage embryos is linked with blastocyst formation and quality.
    Cruz M, Garrido N, Herrero J, Pérez-Cano I, Muñoz M, Meseguer M.
    Reprod Biomed Online, 25:371-381, 2012.

  • Full in vitro fertilization laboratory mechanization: toward robotic assisted reproduction?
    Meseguer M, Kruhne U, Laursen S.
    Fertil Steril, 97:1277-1286, 2012.

  • Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: a retrospective cohort study.
    Meseguer M, Rubio I, Cruz M, Basile N, Marcos J, Requena A.
    Fertil Steril, 98:1481-1489.e10, 2012.

  • Dose of recombinant FSH and oestradiol concentration on day of HCG affect embryo development kinetics.
    Muñoz M, Cruz M, Humaidan P, Garrido N, Pérez-Cano I, Meseguer M.
    Reprod Biomed Online, 25:382-389, 2012.

  • Limited implantation success of direct-cleaved human zygotes: a time-lapse study.
    Rubio I, Kuhlmann R, Agerholm I, Kirk J, Herrero J, Escribá M-J, Bellver J, Meseguer M.
    Fertil Steril, 98:1458-1463, 2012.

  • Time-dependent O2 consumption patterns determined optimal time ranges for selecting viable human embryos.
    Tejera A, Herrero J, Viloria T, Romero JL, Gamiz P, Meseguer M.
    Fertil Steril, 98:849-857.e3, 2012.

  • ¿El futuro de la reproducción son los incubadores con un sistema de time-lapse?
    Tejera A, Meseguer M.
    ASEBIR, 17: 40-41, 2012.

  • Embryo quality, blastocyst and ongoing pregnancy rates in oocyte donation patients whose embryos were monitored by time-lapse imaging.
    Cruz M, Gadea B, Garrido N, Pedersen KS, Martínez M, Pérez-Cano I, Muñoz M, Meseguer M.
    J Assist Reprod Genet, 28:569-573, 2011.

  • Differential transcriptomic profile in spermatozoa achieving pregnancy or not via ICSI.
    García-Herrero S, Garrido N, Martínez-Conejero JA, Remohí J, Pellicer A, Meseguer M.
    Reprod Biomed Online, 22:25-36, 2011.

  • Cinematografía para el estudio de la calidad embrionaria. Embryoscope.
    Herrero J, Tejera A, Cruz M y Meseguer M.
    ASEBIR, 16: 55-61, 2011.

  • Aplicación de la tecnología del embryoscope para la cuentificación de la calidad ovocitaria mediante el análisis de los patrones de respiración.
    Herrero J, Tejera A, Cruz M, Meseguer M.
    ASEBIR, 16: 67-73, 2011.

  • Adenomyosis does not affect implantation, but is associated with miscarriage in patients undergoing oocyte donation.
    Martínez-Conejero JA, Morgan M, Montesinos M, Fortuño S, Meseguer M, Simón C, Horcajadas JA, Pellicer A.
    Fertil Steril, 96:943-950.e1, 2011.

  • The use of morphokinetics as a predictor of embryo implantation.
    Meseguer M, Herrero J, Tejera A, Hilligsoe KM, Ramsing NB, Remohi J
    Hum Reprod, 26:2658-2671, 2011.

  • Effect of sperm DNA fragmentation on pregnancy outcome depends on oocyte quality.
    Meseguer M, Santiso R, Garrido N, García-Herrero S, Remohí J, Fernandez JL.
    Fertil Steril, 95:124-128, 2011.

  • Tejera A, Herrero J, de los Santos MJ, Garrido N, Ramsing N, Meseguer M. Oxygen consumption is a quality marker for human oocyte competence conditioned by ovarian stimulation regimens. Fertil Steril, 96:618-623.e2, 2011.
    Report of results obtained in 2,934 women using donor sperm: donor insemination versus in vitro fertilization according to indication.
    Viloria T, Garrido N, Minaya F, Remohí J, Muñoz M, Meseguer M.
    Fertil Steril, 96:1134-1137, 2011.

  • Relevance of testicular sperm DNA oxidation for the outcome of ovum donation cycles.
    Aguilar C, Meseguer M, García-Herrero S, Gil-Salom M, O'Connor JE, Garrido N.
    Fertil Steril, 94:979-988, 2010.

  • obesity impairs in vitro fertilization outcome without affecting embryo quality.
    Bellver J, Ayllón Y, Ferrando M, Melo M, Goyri E, Pellicer A, Remohí J, Meseguer M. Female
    Fertil Steril, 93:447-454, 2010.

  • Y chromosome microdeletions, sperm DNA fragmentation and sperm oxidative stress as causes of recurrent spontaneous abortion of unknown etiology.
    Bellver J, Meseguer M, Muriel L, Garcia-Herrero S, Barreto MAM, Garda AL, Remohi J, Pellicer A, Garrido N.
    Hum Reprod, 25:1713-1721, 2010.

  • Use of cryo-banked oocytes in an ovum donation programme: a prospective, randomized, controlled, clinical trial.
    Cobo A, Meseguer M, Remohi J, Pellicer A
    Hum Reprod, 25:2239-2246, 2010.

  • Morphologic indicators predict the stage of chromatin condensation of human germinal vesicle oocytes recovered from stimulated cycles.
    Escrich L, Grau N, Meseguer M, Pellicer A, Escribá M-J.
    Fertil Steril, 93:2557-2564, 2010.

  • Profound Transcriptomic Differences Found between Sperm Samples from Sperm Donors vs. Patients Undergoing Assisted Reproduction Techniques Tends to Disappear after Swim-up Sperm Preparation Technique.
    García-Herrero S, Garrido N, Pellicer A, Remohí J, Martínez-Conejero JA, Meseguer M.
    Int J of Fertil Steril, 4: 114 -121, 2010.

  • Ontological evaluation of transcriptional differences between sperm of infertile males and fertile donors using microarray analysis.
    García-Herrero S, Garrido N, Martínez-Conejero JA, Remohí J, Pellicer A, Meseguer M.
    J Assist Reprod Genet, 27:111-120, 2010.

  • Perfiles de expresión génica en hombres infértiles que se someten a reproducción asistida.
    García-Herrero S, Garrido Puchalt N, Pellicer Martínez A, Remohí Giménez J, Martínez Conejero JA, Meseguer M.
    Revista del Laboratorio Clínico, 3:108-117, 2010.

  • The transcriptome of spermatozoa used in homologous intrauterine insemination varies considerably between samples that achieve pregnancy and those that do not.
    García-Herrero S, Meseguer M, Martínez-Conejero JA, Remohí J, Pellicer A, Garrido N.
    Fertil Steril, 94:1360-1373, 2010.

  • La obesidad en las mujeres afecta los resultados de fertilización in vitro pero no la calidad embrionaria.
    J Bellver, Y Aillon, M Ferrando, M Melo, E Goyri, A Pellicer, J Remohí, Meseguer M.
    Revista Iberoamericana de Fertilidad y Reproducción Humana, 27: 73-83, 2010.

  • A prospective, randomized, controlled trial comparing three different gonadotropin regimens in oocyte donors: ovarian response, in vitro fertilization outcome, and analysis of cost minimization.
    Melo M, Bellver J, Garrido N, Meseguer M, Pellicer A, Remohí J.
    Fertil Steril, 94:958-964, 2010.

  • Swim-up procedure selects spermatozoa with longer telomere length.
    Santiso R, Tamayo M, Gosálvez J, Meseguer M, Garrido N, Fernández JL.
    Mutat Res Fundam Mol Mech Mutagen, 688:88-90, 2010.

  • Simultaneous determination in situ of DNA fragmentation and 8-oxoguanine in human sperm.
    Santiso R, Tamayo M, Gosálvez J, Meseguer M, Garrido N, Fernández JL.
    Fertil Steril, 93:314-318, 2010.

  • Cigarette smoking affects specific sperm oxidative defenses but does not cause oxidative DNA damage in infertile men.
    Viloria T, Meseguer M, Martínez-Conejero JA, O'Connor JE, Remohí J, Pellicer A, Garrido N.
    Fertil Steril, 94:631-637, 2010.

  • Antral follicle count (AFC) can be used in the prediction of ovarian response but cannot predict the oocyte/embryo quality or the in vitro fertilization outcome in an egg donation program.
    Barreto Melo MA, Garrido N, Alvarez C, Bellver J, Meseguer M, Pellicer A, Remohí J.
    Fertil Steril, 91:148-156, 2009.

  • First report of the absence of viral load in testicular sperm samples obtained from men with hepatitis C and HIV after washing and their subsequent use.
    Garrido N, Gil-Salom M, Martínez-Jabaloyas JM, Meseguer M.
    Fertil Steril, 92:1012-1015, 2009.

  • Microarray analysis in sperm from fertile and infertile men without basic sperm analysis abnormalities reveals a significantly different transcriptome.
    Garrido N, Martínez-Conejero JA, Jauregui J, Horcajadas JA, Simón C, Remohí J, Meseguer M.
    Fertil Steril, 91:1307-1310, 2009.

  • Métodos de selección embrionaria; una nueva tendencia para transferencias únicas.
    Herrero J, Tejera A, MJ de los Santos, Ramsing N, Garrido N, Meseguer M. Nuevos
    Revista Iberoamericana de Fertilidad y Reproducción Humana Clave, 26: 393-402, 2009.

  • GnRH agonist versus recombinant HCG in an oocyte donation programme: a randomized, prospective, controlled, assessor-blind study.
    Melo M, Busso CE, Bellver J, Alama P, Garrido N, Meseguer M, Pellicer A, Remohí J.
    Reprod Biomed Online, 19:486-492, 2009.

  • Sperm DNA fragmentation levels in testicular sperm samples from azoospermic males as assessed by the sperm chromatin dispersion (SCD) test.
    Meseguer M, Santiso R, Garrido N, Gil-Salom M, Remohí J, Fernandez JL.
    Fertil Steril, 92:1638-1645, 2009.

  • Métodos de selección objetiva de espermatozoides competentes.
    Romany L, Meseguer M, Remohí J, Pellicer A, Garrido N.
    Revista Iberoamericana de Fertilidad y Reproducción Humana Clave, 26: 425-435, 2009.
    Biochemical markers of male infertility: the key role of DNA damage.
    Aguilar C, Garrido N, Viloria T, Luis Fernandez J, Meseguer M.
    Expert Rev Obstet Gynecol, 3:565-576, 2008.

  • Human immunodeficiency type-1 virus (HIV-1) infection in serodiscordant couples (SDCs) does not have an impact on embryo quality or intracytoplasmic sperm injection (ICSI) outcome.
    Barreto Melo MA, Meseguer M, Bellver J, Remohí J, Pellicer A, Garrido N.
    Fertil Steril, 89:141-150, 2008.

  • Influence of paternal age on assisted reproduction outcome.
    Bellver J, Garrido N, Remohí J, Pellicer A, Meseguer M.
    Reprod Biomed Online, 17:595-604, 2008.

  • Contribution of sperm molecular features to embryo quality and assisted reproduction success. Garrido N, Remohí J, Martínez-Conejero JA, García-Herrero S, Pellicer A, Meseguer M.
    Reprod Biomed Online, 17:855-865, 2008.

  • Endometrial Receptivity and Implantation Are Not Affected by the Presence of Uterine Intramural Leiomyomas: A Clinical and Functional Genomics Analysis.
    Horcajadas JA, Goyri E, Higón MA, Martínez-Conejero JA, Gambadauro P, García G, Meseguer M, Simón C, Pellicer A.
    J Clin Endocrinol Metab , 93:3490-3498, 2008.

  • MUC1 in human testis and ejaculated spermatozoa and its relationship to male fertility status.
    Martínez-Conejero JA, Garrido N, Remohí J, Pellicer A, Simón C, Meseguer M.
    Fertil Steril, 90:450-452, 2008.

  • The significance of sperm DNA oxidation in embryo development and reproductive outcome in an oocyte donation program: a new model to study a male infertility prognostic factor.
    Meseguer M, Martínez-Conejero JA, O'Connor JE, Pellicer A, Remohí J, Garrido N.
    Fertil Steril, 89:1191-1199, 2008.

  • The effect of cancer on sperm DNA fragmentation as measured by the sperm chromatin dispersion test.
    Meseguer M, Santiso R, Garrido N, Fernandez JL .
    Fertil Steril, 90:225-227, 2008.

  • Improvements achieved in an oocyte donation program over a 10-year period: sequential increase in implantation and pregnancy rates and decrease in high-order multiple pregnancies.
    Budak E, Garrido N, Soares SR, Melo MAB, Meseguer M, Pellicer A, Remohí J
    Fertil Steril, 88:342-349, 2007.

  • Ovarian stimulation length, number of follicles higher than 17 mm and estradiol on the day of human chorionic gonadotropin administration are risk factors for multiple pregnancy in intrauterine insemination.
    Garrido N, Melo MAB, Simón C, RemohÍ J, Pellicer A, Meseguer M.
    Reproductive Medicine and Biology, 6:19-26, 2007.

  • Reply of the Authors.
    Garrido N, Meseguer M.
    Fertil Steril, 87:1241-1242, 2007.

  • The Human Sperm Glutathione System: A Key Role in Male Fertility and Successful Cryopreservation.
    Meseguer M, Antonio Martinez-Conejero J, Muriel L, Pellicer A, Remohi J, Garrido N.
    Drug Metabolism Letters, 1:121-126, 2007.

  • Sperm selection by swim-up in terms of deoxyribonucleic acid fragmentation as measured by the sperm chromatin dispersion test is altered in heavy smokers.
    Viloria T, Garrido N, Fernández JL, Remohí J, Pellicer A, Meseguer M.
    Fertil Steril, 88:523-525, 2007.

  • Use of washed sperm for assisted reproduction in HIV-positive males without checking viral absence. A risky business?
    Garrido N, Meseguer M.
    Hum Reprod, 21:567-568, 2006.

  • Interpretation of sperm morphology analysis in gynecological practice for infertility.
    Garrido N, Meseguer M, Pellicer A.
    Expert Rev Obstet Gynecol, 1:7-9, 2006.

  • The effectiveness of modified sperm washes in severely oligoasthenozoospermic men infected with human immunodeficiency and hepatitis C viruses.
    Garrido N, Remohi J, Pellicer A, Meseguer M.
    Fertil Steril, 86:1544-1546, 2006.

  • The significance of premature luteinization in an oocyte-donation programme.
    Melo MAB, Meseguer M, Garrido N, Bosch E, Pellicer A, Remohí J.
    Hum Reprod, 21:1503-1507, 2006.

  • Effect of sperm glutathione peroxidases 1 and 4 on embryo asymmetry and blastocyst quality in oocyte donation cycles.
    Meseguer M, Delossantos M, Simon C, Pellicer A, Remohi J, Garrido N.
    Fertil Steril, 86:1376-1385, 2006.

  • Sperm cryopreservation in oncological patients: a 14-year follow-up study.
    Meseguer M, Molina N, García-Velasco JA, Remohí J, Pellicer A, Garrido N.
    Fertil Steril, 85:640-645, 2006.

  • Value of the sperm deoxyribonucleic acid fragmentation level, as measured by the sperm chromatin dispersion test, in the outcome of in vitro fertilization and intracytoplasmic sperm injection.
    Muriel L, Garrido N, Fernández JL, Remohí J, Pellicer A, de los Santos MJ, Meseguer M.
    Fertil Steril, 85:371-383, 2006.

  • Estudio comparativo de dos medios de cultivo HTF e ISM-1: implicaciones en el fenotipo embrionario y resultados clínicos.
    Gimeno L, Lopez MA, Meseguer M, Santos JM, Pellicer A, Remohí J, Santos MJ.
    Revista Iberoamericana de Fertilidad y Reproducción Humana, 23: 375-382, 2006.

  • De la fragmentación del DNA espermático en los fumadores tras la capacitación mediante swim-up.
    Viloria T, Garrido N, Fernandez J, Remohí J, Pellicer A, Muriel L, Meseguer M.
    ASEBIR, 1:15-21, 2006.

  • Semen characteristics in human immunodeficiency virus (HIV)- and hepatitis C (HCV)-seropositive males: predictors of the success of viral removal after sperm washing. Hum Reprod, 20:1028-1034, 2005.

  • of the sperm chromatin dispersion test in predicting pregnancy outcome in intrauterine insemination: a blind prospective study*.
    Muriel L, Meseguer M, Fernández JL, Alvarez J, Remohí J, Pellicer A, Garrido N. Value
    Hum Reprod, 21:738-744, 2005.

  • Smoking habits of parents and male: female ratio in spermatozoa and preimplantation embryos.
    Viloria T, Rubio MC, Rodrigo L, Calderon G, Mercader A, Mateu E, Meseguer M, Remohi J, Pellicer A.
    Hum Reprod, 20:2517-2522, 2005.

  • Relationship among standard semen parameters, glutathione peroxidase/glutathione reductase activity, and mRNA expression and reduced glutathione content in ejaculated spermatozoa from fertile and infertile men.
    Garrido N, Meseguer M, Alvarez J, Simón C, Pellicer A, Remohí J.
    Fertil Steril, 82:1059-1066, 2004.

  • Reproductive issues for persons with HIV.
    Garrido N, Meseguer M, Bellver J.
    Am J Obstet Gynecol, 190:1489, 2004.

  • Report of the results of a 2 year programme of sperm wash and ICSI treatment for human immunodeficiency virus and hepatitis C virus serodiscordant couples.
    Garrido N, Meseguer M, Bellver J, Remohí J, Simón C, Pellicer A.
    Hum Reprod, 19:2581-2586, 2004.

  • Assisted reproduction in hiv and hcv infected men of serodiscordant couples.
    Garrido N, Meseguer M, Simon C, Pellicer A, RemohÍ J.
    Arch Androl, 50:105-111, 2004.

  • Reply of the authors.
    Meseguer M, Garrido N, Bosch-Bastida E.
    Fertil Steril, 82:515, 2004.

  • Role of cholesterol, calcium, and mitochondrial activity in the susceptibility for cryodamage after a cycle of freezing and thawing.
    Meseguer M, Garrido N, Martínez-Conejero JA, Simón C, Pellicer A, Remohí J.
    Fertil Steril, 81:588-594, 2004.

  • Testicular Sperm Extraction (TESE) and Intracytoplasmic Sperm Injection (ICSI) in Hypogonadotropic Hypogonadism with Persistent Azoospermia After Hormonal Therapy.
    Meseguer M, Garrido N, Remohí J, Pellicer A, Gil-Salom M.
    J Assist Reprod Genet, 21:91-94, 2004.

  • Concentration of Glutathione and Expression of Glutathione Peroxidases 1 and 4 in Fresh Sperm Provide a Forecast of the Outcome of Cryopreservation of Human Spermatozoa.
    Meseguer M, Garrido N, Simón C, Pellicer A, Remohí J.
    J Androl, 25:773-780, 2004.

  • MUC1 e IL-6: posibles marcadores de fertilidad en reproducción humana.
    Martínez-Conejero J, Garrido N, Simón C, Pellicer A, Remohí J, Meseguer M.
    Revisión. ASEBIR,9: 12-22, 2004.

  • Affecting the Results in a Program of Artificial Insemination With Donor Sperm. A 12-year Retrospective Review of More Than 1800 Cycles.
    Zuzuarregui JL, Meseguer M, Garrido N, Simón C, Pellicer A, Remohí J. Parameters
    J Assist Reprod Genet, 21:109-118, 2004.

  • Testicular sperm extraction (TESE) and ICSI in patients with permanent azoospermia after chemotherapy.
    Meseguer M.
    Hum Reprod, 18:1281-1285, 2003.

  • Human immunodeficiency virus (HIV) and Hepatitis C virus (HCV) presence in washed semen: are they absent or present although non-infective.
    Meseguer M, Garrido N.
    ART and Science Clave, 3: 10-12, 2003.

  • Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male infertility. Garrido N, Meseguer M, Pellicer A.
    Asian J Androl, 6: 59-65, 2004.

  • Relationship among standard semen parameters, Calcium, Cholesterol and Mitochondrial Activity in ejaculated spermatozoa from fertile and infertile males.
    Meseguer M, Garrido N, Martínez-Conejero J, Simón C, Pellicer A, Remohí J.
    J Assist Reprod Genet, 21: 449-455,2004.

  • Premio al mejor artículo original publicado en la Revista Iberoamericana de Fertilidad. TGF-β1 regula in vitro a la mucina endometrial humana MUC1 durante la implantación embrionaria.
    Meseguer M, Martínez-Conejero J, Remohí J, Aplin J, Pellicer A, Remohí J.
    Revista Iberoamericana de Fertilidad y Reproducción Humana, 20:167-17, 2003.

  • Hormonal and embryonic regulation of chemokines IL-8, MCP-1 and RANTES in the human endometrium during the window of implantation.
    Caballero-Campo P, Domínguez F, Coloma J, Meseguer M, Remohí J, Pellicer A, Simón C.
    Mol Hum Reprod, 8:375-384, 2002.

  • Sperm and oocyte donor selection and management: experience of a 10 year follow-up of more than 2100 candidates.
    Garrido N, Zuzuarregui JL, Meseguer M, Simón C, Remohí J, Pellicer A.
    Hum Reprod, 17:3142-3148, 2002.

  • In vitro fertilization with intracytoplasmic sperm injection for human immunodeficiency virus-1 serodiscordant couples.
    Garrido N, Meseguer M, Bellver J.
    Am J Obstet Gynecol, 187:1121, 2002.

  • Flow cytometry in human reproductive biology.
    Garrido N, Meseguer M, Remohi J, Pellicer A, Simón C.
    Gynecol Endocrinol, 16:505-521, 2002.

  • Factor Masculino y. Técnicas de Reproducción Asistida.
    Garrido N, Meseguer M, Gámiz P, Simón C, Pellicer A, Remohí J.
    ASEBIR, 7: 10-24, 2002.

  • Factores influyentes en los resultados de congelación y descongelación del semen humano.
    Garrido N, Meseguer M, Simón C, Pellicer A, Remohí J.
    ASEBIR, 7: 21-27, 2002.

  • Transmembrane and Truncated (SEC) Isoforms of MUC1 in Human Endometrium and Fallopian Tube.
    Hey N, Meseguer M, Simón C, Smorodinsky N, Wreschner D, Ortíz M, Aplin J.
    Reprod Biol Endocrinol, 1:1-12, 2003.

  • Comparison of polymerase chain reaction–dependent methods for determining the presence of human immunodeficiency virus and hepatitis C virus in washed sperm.
    Meseguer M, Garrido N, Gimeno C, Remohí J, Simón C, Pellicer A.
    Fertil Steril, 78:1199-1202, 2002.

  • A. Gender selection: ethical, scientific, legal, and practical issues. J Assist Reprod Genet,Meseguer M, Garrido N, Remohi J, Simon C, Pellicer . 19:443-446, 2002.Zuzuarregui J, Garrido N, Meseguer M, Simón C, Pellicer A, Remohí J. Parámetros que afectan a los resultados de la inseminación artificial con semen de donante. Revista Iberoamericana de Fertilidad y Reproducción Humana, 19: 387-397, 2002.

  • MUC1, glycans and the cell-surface barrier to embryo implantation.
    Aplin JD, Meseguer M, Simón C, Ortíz M, Croxatto H, Jones C.
    Biochem Soc Trans, 29:153, 2001.

  • Detección del virus de la Hepatitis C en semen lavado de varones seropositivos para su posterior uso en reproducción asistida: resultados preliminares.
    Garrido N, Meseguer M, Simón C, Pellicer A, Remohí J.
    Actualidad Andrológica, 9: 56-60, 2001.

  • Human Endometrial Mucin MUC1 Is Up-Regulated by Progesterone and Down-Regulated In Vitro by the Human Blastocyst1.
    Meseguer M, Aplin JD, Caballero-Campo P, O’Connor JE, Martín JC, Remohí J, Pellicer A, Simón C.
    Biol Reprod, 64:590-601, 2001.

  • Remohí Es segura la utilización del semen de donante? Seguimiento de enfermedades infecciosas y desórdenes hereditarios en la población de donantes de semen y el programa de IAD; experiencia de 10 años.
    Meseguer M, Garrido N, Simon C, Pellicer A, Remohí J.
    Actualidad Andrológica, 9: 61-67, 2001.

  • Increased Adhesiveness in Cultured Endometrial-Derived Cells Is Related to the Absence of Moesin Expression1.
    Martín JC, Jasper MJ, Valbuena D, Meseguer M, Remohí J, Pellicer A, Simón C.
    Biol Reprod, 63:1370-1376, 2000.

  • Embryonic regulation of endometrial molecules in human implantation.
    Simón C.,Martín J, Meseguer M, Caballero-Campo P, Valbuena D, And Pellicer A.
    J Reprod Fertil Suppl, 55: 43-45: 2000
    O-126. Embryonic regulation of MCP-1 in human endometrial epithelial cells.
    Caballero-Campo P, Meseguer M, Martín JC, Coloma J, O'Connor JE, Remohí J, Pellicer A, Simón C.
    Hum Reprod, 14:69-70, 1999.

  • MUC1 and endometrial receptivity.
    Meseguer M.
    Mol Hum Reprod, 4:1089-1098, 1998.


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