BMI and miscarriage after IVF.

Curr Opin Obstet Gynecol. 2022 Jun 1;34(3):114-121. 2022 doi: 10.1097/GCO.0000000000000778


Female obesity is related to poorer outcome in natural and assisted conception, including an increased risk of miscarriage. Embryo morphology, assessed by conventional methods or by morphokinetics, does not seem to be affected by excess weight, with similar blastocyst formation and quality than normal weight women reported in IVF cycles. Embryo aneuploidy is not increased, and higher miscarriages rates are seen after euploid embryo transfer in obese women. Disturbances of the uterus or its environment induced by female obesity seem to be the most likely cause of the increased risk of miscarriage, although metabolomic, epigenetic or mitochondrial oocyte and embryo dysfunction cannot be ruled out as cannot congenital nomalies. In the context of all the above, weight reduction before pregnancy should be advised in obese women trying to become pregnant.